{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T23:59:35Z","timestamp":1776211175179,"version":"3.50.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T00:00:00Z","timestamp":1678060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T00:00:00Z","timestamp":1678060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1007\/s00210-023-02454-0","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T11:30:32Z","timestamp":1678102232000},"page":"1827-1836","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Radioprotective effects of \u03b12-adrenergic receptor agonist dexmedetomidine on X-ray irradiation-induced pancreatic islet cell damage"],"prefix":"10.1007","volume":"396","author":[{"given":"Filiz","family":"Mercantepe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levent","family":"Tumkaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tolga","family":"Mercantepe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sema Yilmaz","family":"Rakici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serpil","family":"Ciftel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sedat","family":"Ciftel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,3,6]]},"reference":[{"key":"2454_CR1","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1002\/1097-0142(19880915)62:6<1091::AID-CNCR2820620611>3.0.CO;2-A","volume":"62","author":"F Ahmadu-Suka","year":"1988","unstructured":"Ahmadu-Suka F, Gillette EL, Withrow SJ et al (1988) Exocrine pancreatic function following intraoperative irradiation of the canine pancreas. Cancer 62:1091\u20131095. https:\/\/doi.org\/10.1002\/1097-0142(19880915)62:6%3c1091::AID-CNCR2820620611%3e3.0.CO;2-A","journal-title":"Cancer"},{"key":"2454_CR2","doi-asserted-by":"publisher","unstructured":"Araujo IK, Mu\u00f1oz-Guglielmetti D, Moll\u00e0 M (2020) Radiation-induced damage in the lower gastrointestinal tract: clinical presentation, diagnostic tests and treatment options. Best Pract Res Clin Gastroenterol 48\u201349. https:\/\/doi.org\/10.1016\/j.bpg.2020.101707","DOI":"10.1016\/j.bpg.2020.101707"},{"key":"2454_CR3","doi-asserted-by":"publisher","first-page":"3673","DOI":"10.1200\/JCO.2013.49.3205","volume":"31","author":"GT Armstrong","year":"2013","unstructured":"Armstrong GT, Oeffinger KC, Chen Y et al (2013) Modifiable risk factors and major cardiac events among adult survivors of childhood cancer. J Clin Oncol 31:3673\u20133680. https:\/\/doi.org\/10.1200\/JCO.2013.49.3205","journal-title":"J Clin Oncol"},{"key":"2454_CR4","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/nrc1950","volume":"6","author":"SM Bentzen","year":"2006","unstructured":"Bentzen SM (2006) Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology. Nat Rev Cancer 6:702\u2013713. https:\/\/doi.org\/10.1038\/nrc1950","journal-title":"Nat Rev Cancer"},{"key":"2454_CR5","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1016\/S0140-6736(17)31610-0","volume":"390","author":"N Bhakta","year":"2017","unstructured":"Bhakta N, Liu Q, Ness KK et al (2017) The cumulative burden of surviving childhood cancer: an initial report from the St Jude Lifetime Cohort Study (SJLIFE). Lancet 390:2569\u20132582. https:\/\/doi.org\/10.1016\/S0140-6736(17)31610-0","journal-title":"Lancet"},{"key":"2454_CR6","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/S0360-3016(96)90034-6","volume":"34","author":"LJ Boersma","year":"1996","unstructured":"Boersma LJ, Theuws JCM, Kwa SLS et al (1996) Regional variation in functional subunit density in the lung: regarding Liao et al. IJROBP 32(5):1359-1370; 1995. Int J Radiat Oncol Biol Phys 34:1187\u20131188. https:\/\/doi.org\/10.1016\/S0360-3016(96)90034-6","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2454_CR7","doi-asserted-by":"publisher","unstructured":"Braun M (2014) The somatostatin receptor in human pancreatic \u03b2-cells. Vitam Horm 95:165\u2013193.\u00a0https:\/\/doi.org\/10.1016\/b978-0-12-800174-5.00007-7","DOI":"10.1016\/b978-0-12-800174-5.00007-7"},{"key":"2454_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/2930463","volume":"2020","author":"Y Chai","year":"2020","unstructured":"Chai Y, Cao Z, Yu R et al (2020) Dexmedetomidine attenuates LPS-induced monocyte-endothelial adherence via inhibiting Cx43\/PKC- \u03b1 \/NOX2\/ROS signaling pathway in monocytes. Oxid Med Cell Longev 2020:1\u201310. https:\/\/doi.org\/10.1155\/2020\/2930463","journal-title":"Oxid Med Cell Longev"},{"key":"2454_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fonc.2021.757973","volume":"11","author":"G Chen","year":"2021","unstructured":"Chen G, Han Y, Zhang H et al (2021) Radiotherapy-induced digestive injury: diagnosis, treatment and mechanisms. Front Oncol 11:1\u201318. https:\/\/doi.org\/10.3389\/fonc.2021.757973","journal-title":"Front Oncol"},{"key":"2454_CR10","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00540-021-02982-0","volume":"36","author":"M Chen","year":"2022","unstructured":"Chen M, Li X, Mu G (2022) Myocardial protective and anti-inflammatory effects of dexmedetomidine in patients undergoing cardiovascular surgery with cardiopulmonary bypass: a systematic review and meta-analysis. J Anesth 36:5\u201316. https:\/\/doi.org\/10.1007\/s00540-021-02982-0","journal-title":"J Anesth"},{"key":"2454_CR11","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s004310050617","volume":"156","author":"A Cicognani","year":"1997","unstructured":"Cicognani A, Cacciari E, Mancini AF et al (1997) Abnormal insulin response to glucose following treatment for Wilms\u2019 tumor in childhood. Eur J Pediatr 156:371\u2013375. https:\/\/doi.org\/10.1007\/s004310050617","journal-title":"Eur J Pediatr"},{"key":"2454_CR12","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1007\/s12640-021-00379-1","volume":"39","author":"S \u00c7\u0131nar","year":"2021","unstructured":"\u00c7\u0131nar S, T\u00fcmkaya L, Mercantepe T et al (2021) Can dexmedetomidine be effective in the protection of radiotherapy-induced brain damage in the rat? Neurotox Res 39:1338\u20131351. https:\/\/doi.org\/10.1007\/s12640-021-00379-1","journal-title":"Neurotox Res"},{"key":"2454_CR13","doi-asserted-by":"publisher","first-page":"486","DOI":"10.33594\/000000035","volume":"52","author":"EL Damsteegt","year":"2019","unstructured":"Damsteegt EL, Hassan Z, Hewawasam NV et al (2019) A novel role for somatostatin in the survival of mouse pancreatic beta cells. Cell Physiol Biochem 52:486\u2013502. https:\/\/doi.org\/10.33594\/000000035","journal-title":"Cell Physiol Biochem"},{"key":"2454_CR14","doi-asserted-by":"publisher","first-page":"172401","DOI":"10.1016\/j.ejphar.2019.05.030","volume":"856","author":"I Dardalas","year":"2019","unstructured":"Dardalas I, Stamoula E, Rigopoulos P et al (2019) Dexmedetomidine effects in different experimental sepsis in vivo models. Eur J Pharmacol 856:172401. https:\/\/doi.org\/10.1016\/j.ejphar.2019.05.030","journal-title":"Eur J Pharmacol"},{"key":"2454_CR15","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1097\/MED.0b013e3283631820","volume":"20","author":"KH Darzy","year":"2013","unstructured":"Darzy KH (2013) Radiation-induced hypopituitarism. Curr Opin Endocrinol Diabetes Obes 20:342\u2013353. https:\/\/doi.org\/10.1097\/MED.0b013e3283631820","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"2454_CR16","doi-asserted-by":"publisher","unstructured":"De Ruysscher D, Niedermann G, Burnet NG, et al (2019) Radiotherapy toxicity. Nat Rev Dis Prim 5: https:\/\/doi.org\/10.1038\/s41572-019-0064-5","DOI":"10.1038\/s41572-019-0064-5"},{"key":"2454_CR17","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1016\/S1470-2045(12)70323-6","volume":"13","author":"F de Vathaire","year":"2012","unstructured":"de Vathaire F, El-Fayech C, Ben Ayed FF et al (2012) Radiation dose to the pancreas and risk of diabetes mellitus in childhood cancer survivors: a retrospective cohort study. Lancet Oncol 13:1002\u20131010. https:\/\/doi.org\/10.1016\/S1470-2045(12)70323-6","journal-title":"Lancet Oncol"},{"key":"2454_CR18","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/jso.2930340113","volume":"34","author":"DF Du Toit","year":"1987","unstructured":"Du Toit DF, Heydenrych JJ, Smit B et al (1987) The effect of ionizing radiation on the primate pancreas: an endocrine and morphologic study. J Surg Oncol 34:43\u201352. https:\/\/doi.org\/10.1002\/jso.2930340113","journal-title":"J Surg Oncol"},{"key":"2454_CR19","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.jhazmat.2018.07.005","volume":"359","author":"EF El-Maraghi","year":"2018","unstructured":"El-Maraghi EF, Abdel-Fattah KI, Soliman SM, El-Sayed WM (2018) Taurine provides a time-dependent amelioration of the brain damage induced by \u0393-irradiation in rats. J Hazard Mater 359:40\u201346. https:\/\/doi.org\/10.1016\/j.jhazmat.2018.07.005","journal-title":"J Hazard Mater"},{"key":"2454_CR20","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.lfs.2005.04.068","volume":"78","author":"Y Erbil","year":"2005","unstructured":"Erbil Y, \u00d6ztezcan S, Giri\u015f M et al (2005) The effect of glutamine on radiation-induced organ damage. Life Sci 78:376\u2013382. https:\/\/doi.org\/10.1016\/j.lfs.2005.04.068","journal-title":"Life Sci"},{"key":"2454_CR21","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1093\/jnci\/djz152","volume":"112","author":"DN Friedman","year":"2020","unstructured":"Friedman DN, Moskowitz CS, Hilden P et al (2020) Radiation dose and volume to the pancreas and subsequent risk of diabetes mellitus: a report from the Childhood Cancer Survivor Study. J Natl Cancer Inst 112:525\u2013532. https:\/\/doi.org\/10.1093\/jnci\/djz152","journal-title":"J Natl Cancer Inst"},{"key":"2454_CR22","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.radonc.2013.04.013","volume":"107","author":"C Gemici","year":"2013","unstructured":"Gemici C, Sargin M, Uygur-Bayramicli O et al (2013) Risk of endocrine pancreatic insufficiency in patients receiving adjuvant chemoradiation for resected gastric cancer. Radiother Oncol 107:195\u2013199. https:\/\/doi.org\/10.1016\/j.radonc.2013.04.013","journal-title":"Radiother Oncol"},{"key":"2454_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13014-018-1189-5","volume":"13","author":"C Gemici","year":"2018","unstructured":"Gemici C, Yaprak G, Ozdemir S et al (2018) Volumetric decrease of pancreas after abdominal irradiation, it is time to consider pancreas as an organ at risk for radiotherapy planning 11 Medical and Health Sciences 1103 Clinical Sciences. Radiat Oncol 13:1\u20137. https:\/\/doi.org\/10.1186\/s13014-018-1189-5","journal-title":"Radiat Oncol"},{"key":"2454_CR24","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1345\/aph.1H314","volume":"41","author":"AT Gerlach","year":"2007","unstructured":"Gerlach AT, Dasta JF (2007) Dexmedetomidine: an updated review. Ann Pharmacother 41:245\u2013254. https:\/\/doi.org\/10.1345\/aph.1H314","journal-title":"Ann Pharmacother"},{"key":"2454_CR25","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1159\/000129296","volume":"25","author":"HJ Heijmans","year":"1993","unstructured":"Heijmans HJ, Mehta D, Kleibeuker JH et al (1993) The reduced canine pancreas to study the effects of intra-operative radiotherapy. Eur Surg Res 25:321\u2013328. https:\/\/doi.org\/10.1159\/000129296","journal-title":"Eur Surg Res"},{"key":"2454_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/01.prs.0000440818.23647.0b","volume":"133","author":"JR Hubenak","year":"2014","unstructured":"Hubenak JR, Zhang Q, Branch CD, Kronowitz SJ (2014) Mechanisms of injury to normal tissue after radiotherapy: a review. Plast Reconstr Surg 133:1\u201312. https:\/\/doi.org\/10.1097\/01.prs.0000440818.23647.0b","journal-title":"Plast Reconstr Surg"},{"key":"2454_CR27","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1152\/ajpendo.00207.2012","volume":"303","author":"B Kailey","year":"2012","unstructured":"Kailey B, van de Bunt M, Cheley S et al (2012) SSTR2 is the functionally dominant somatostatin receptor in human pancreatic \u03b2- and \u03b1-cells. Am J Physiol - Endocrinol Metab 303:1107\u20131117. https:\/\/doi.org\/10.1152\/ajpendo.00207.2012","journal-title":"Am J Physiol - Endocrinol Metab"},{"key":"2454_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/and.13985","volume":"53","author":"E K\u00f6l\u00fck\u00e7\u00fc","year":"2021","unstructured":"K\u00f6l\u00fck\u00e7\u00fc E, Parlakta\u015f BS, K\u00f6l\u00fck\u00e7\u00fc V et al (2021) Protective effects of dexmedetomidine on ischaemia-reperfusion injury in an experimental rat model of priapism. Andrologia 53:1\u201310. https:\/\/doi.org\/10.1111\/and.13985","journal-title":"Andrologia"},{"key":"2454_CR29","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.jclinane.2016.06.031","volume":"34","author":"D Kutanis","year":"2016","unstructured":"Kutanis D, Erturk E, Besir A et al (2016) Dexmedetomidine acts as an oxidative damage prophylactic in rats exposed to ionizing radiation. J Clin Anesth 34:577\u2013585. https:\/\/doi.org\/10.1016\/j.jclinane.2016.06.031","journal-title":"J Clin Anesth"},{"key":"2454_CR30","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1001\/archinternmed.2009.209","volume":"169","author":"LR Meacham","year":"2009","unstructured":"Meacham LR, Sklar CA, Li S et al (2009) Diabetes mellitus in long-term survivors of childhood cancer - Increased risk associated with radiation therapy: a report for the childhood cancer survivor study. Arch Intern Med 169:1381\u20131388. https:\/\/doi.org\/10.1001\/archinternmed.2009.209","journal-title":"Arch Intern Med"},{"key":"2454_CR31","doi-asserted-by":"publisher","first-page":"3240","DOI":"10.1200\/JCO.2016.66.6545","volume":"34","author":"S Mostoufi-Moab","year":"2016","unstructured":"Mostoufi-Moab S, Seidel K, Leisenring WM et al (2016) Endocrine abnormalities in aging survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. J Clin Oncol 34:3240\u20133247. https:\/\/doi.org\/10.1200\/JCO.2016.66.6545","journal-title":"J Clin Oncol"},{"key":"2454_CR32","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/S1470-2045(12)70340-6.Abdominal","volume":"13","author":"KC Oeffinger","year":"2014","unstructured":"Oeffinger KC, Sklar C (2014) Abdominal radiation and diabetes\u202f: one more piece in the puzzle. Lancet Oncol 13:961\u2013962. https:\/\/doi.org\/10.1016\/S1470-2045(12)70340-6.Abdominal","journal-title":"Lancet Oncol"},{"key":"2454_CR33","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s11064-019-02922-1","volume":"45","author":"Z Qiu","year":"2020","unstructured":"Qiu Z, Lu P, Wang K et al (2020) Dexmedetomidine inhibits neuroinflammation by altering microglial M1\/M2 polarization through MAPK\/ERK pathway. Neurochem Res 45:345\u2013353. https:\/\/doi.org\/10.1007\/s11064-019-02922-1","journal-title":"Neurochem Res"},{"key":"2454_CR34","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s00268-013-2287-z","volume":"34","author":"M Ren","year":"2014","unstructured":"Ren M, Chao M, Chang W, Shang Z (2014) Predictive factors of thyroid cancer in patients with Graves \u2019 disease. World J Surg 34:80\u201387. https:\/\/doi.org\/10.1007\/s00268-013-2287-z","journal-title":"World J Surg"},{"key":"2454_CR35","first-page":"485","volume":"22","author":"C Rerup","year":"1970","unstructured":"Rerup C (1970) Drugs producing diabetes through damage of the insulin secreting cells. Pharmacol Rev 22:485\u2013518","journal-title":"Pharmacol Rev"},{"key":"2454_CR36","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/0167-8140(91)90011-5","volume":"22","author":"Y Sarri","year":"1991","unstructured":"Sarri Y, Conill C, Verger E et al (1991) Effects of single dose irradiation on pancreatic beta-cell function. Radiother Oncol 22:143\u2013144. https:\/\/doi.org\/10.1016\/0167-8140(91)90011-5","journal-title":"Radiother Oncol"},{"key":"2454_CR37","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1586\/era.12.27","volume":"12","author":"T Sathyapalan","year":"2012","unstructured":"Sathyapalan T, Dixit S (2012) Radiotherapy-induced hypopituitarism\u202f: a review. Expert Rev Anticancer Ther 12:669\u2013683","journal-title":"Expert Rev Anticancer Ther"},{"key":"2454_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2377-12-20","volume":"12","author":"M Schoeler","year":"2012","unstructured":"Schoeler M, Loetscher PD, Rossaint R et al (2012) Dexmedetomidine is neuroprotective in an in vitro model for traumatic brain injury. BMC Neurol 12:1\u20137. https:\/\/doi.org\/10.1186\/1471-2377-12-20","journal-title":"BMC Neurol"},{"key":"2454_CR39","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.radonc.2017.04.017","volume":"123","author":"B Stam","year":"2017","unstructured":"Stam B, Peulen H, Guckenberger M et al (2017) Dose to heart substructures is associated with non-cancer death after SBRT in stage I-II NSCLC patients. Radiother Oncol 123:370\u2013375. https:\/\/doi.org\/10.1016\/j.radonc.2017.04.017","journal-title":"Radiother Oncol"},{"key":"2454_CR40","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1016\/S0140-6736(16)30580-3","volume":"388","author":"X Su","year":"2016","unstructured":"Su X, Meng ZT, Wu XH et al (2016) Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial. Lancet 388:1893\u20131902. https:\/\/doi.org\/10.1016\/S0140-6736(16)30580-3","journal-title":"Lancet"},{"key":"2454_CR41","first-page":"633","volume":"346","author":"C Teinturier","year":"1995","unstructured":"Teinturier C, Tourmade M, Zucman S et al (1995) Diabetes mellitus after abdominal radiation therapy. Lab Investig 346:633\u2013634","journal-title":"Lab Investig"},{"key":"2454_CR42","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s00210-018-1581-6","volume":"392","author":"A Topcu","year":"2019","unstructured":"Topcu A, Mercantepe F, Rakici S et al (2019) An investigation of the effects of N-acetylcysteine on radiotherapy-induced testicular injury in rats. Naunyn Schmiedebergs Arch Pharmacol 392:147\u2013157. https:\/\/doi.org\/10.1007\/s00210-018-1581-6","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"2454_CR43","doi-asserted-by":"publisher","first-page":"3257","DOI":"10.1200\/JCO.2013.54.4379","volume":"32","author":"FA Van Nimwegen","year":"2014","unstructured":"Van Nimwegen FA, Schaapveld M, Janus CPM et al (2014) Risk of diabetes mellitus in long-term survivors of Hodgkin lymphoma. J Clin Oncol 32:3257\u20133263. https:\/\/doi.org\/10.1200\/JCO.2013.54.4379","journal-title":"J Clin Oncol"},{"key":"2454_CR44","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1038\/s41592-022-01615-y","volume":"19","author":"J Vollert","year":"2022","unstructured":"Vollert J, Macleod M, Dirnagl U et al (2022) The EQIPD framework for rigor in the design, conduct, analysis and documentation of animal experiments. Nat Methods 19:1334\u20131337. https:\/\/doi.org\/10.1038\/s41592-022-01615-y","journal-title":"Nat Methods"},{"key":"2454_CR45","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1007\/s40262-017-0507-7","volume":"56","author":"MAS Weerink","year":"2017","unstructured":"Weerink MAS, Struys MMRF, Hannivoort LN et al (2017) Clinical pharmacokinetics and pharmacodynamics of dexmedetomidine. Clin Pharmacokinet 56:893\u2013913. https:\/\/doi.org\/10.1007\/s40262-017-0507-7","journal-title":"Clin Pharmacokinet"},{"key":"2454_CR46","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1515\/CCLM.2011.250","volume":"49","author":"H Yang","year":"2011","unstructured":"Yang H, Jin X, Lam CWK, Yan SK (2011) Oxidative stress and diabetes mellitus. Clin Chem Lab Med 49:1773\u20131782. https:\/\/doi.org\/10.1515\/CCLM.2011.250","journal-title":"Clin Chem Lab Med"},{"key":"2454_CR47","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1093\/jrr\/rry043","volume":"59","author":"SH You","year":"2018","unstructured":"You SH, Cho MY, Sohn JH, Lee CG (2018) Pancreatic radiation effect in apoptosis-related rectal radiation toxicity. J Radiat Res 59:529\u2013540. https:\/\/doi.org\/10.1093\/jrr\/rry043","journal-title":"J Radiat Res"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-023-02454-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-023-02454-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-023-02454-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T08:04:38Z","timestamp":1689149078000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-023-02454-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,6]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["2454"],"URL":"https:\/\/doi.org\/10.1007\/s00210-023-02454-0","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,6]]},"assertion":[{"value":"22 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This experimental study was performed with approval from Recep Tayyip Erdogan University Animal Research Ethics Committee (Rize, Turkey; date: 30\/06\/2022; Approval Number: 2022\/23).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}