{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:07:23Z","timestamp":1767139643788,"version":"build-2238731810"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:00:00Z","timestamp":1683072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:00:00Z","timestamp":1683072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1007\/s00210-023-02498-2","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T05:02:32Z","timestamp":1683090152000},"page":"2943-2955","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of non-volatile metabolites and quantitation of the anti-arthritic alkaloid sinomenine from blood fruit (Haematocarpus validus (Miers) Bakh.f. ex Forman)"],"prefix":"10.1007","volume":"396","author":[{"given":"Blessymole K.","family":"Alex","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uttpal","family":"Anand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eapen P.","family":"Koshy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhijit","family":"Dey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,5,3]]},"reference":[{"key":"2498_CR1","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1002\/ardp.19913240612","volume":"324","author":"U Abbasoglu","year":"1991","unstructured":"Abbasoglu U, Sener B, Gunay Y, Temizer H (1991) Antimicrobial activity of some isoquinoline alkaloids. Arch Der Pharmazie 324:379\u2013380. https:\/\/doi.org\/10.1002\/ardp.19913240612","journal-title":"Arch Der Pharmazie"},{"key":"2498_CR2","unstructured":"Alex, BK (2018) Bioprospecting of the wild edible and underutilized plant Haematocarpus validus (Miers) Bakh.f. ex Forman. Ph. D. Dissertation, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad, India. http:\/\/krishikosh.egranth.ac.in\/handle\/1\/5810058530"},{"key":"2498_CR3","doi-asserted-by":"publisher","unstructured":"Alex, BK, Koshy, EP, Jacob, S, Thomas, G (2021) Wild edible fruit crop Haematocarpus validus (Miers) Bakh.f. ex Forman (Khoon phal): a novel source of nutraceuticals. J Food Sci Technol. https:\/\/doi.org\/10.1007\/s13197-021-04997-7","DOI":"10.1007\/s13197-021-04997-7"},{"key":"2498_CR4","unstructured":"Backer, CA, van den Brink, RCB (1963) Flora of Java, vol. 1. P. Noordhoff, Groningen, Netherlands, pp 151\u2013159. https:\/\/books.google.co.in\/books?id=I1FCAQAAIAAJ"},{"key":"2498_CR5","doi-asserted-by":"publisher","unstructured":"Barbosa-Filho, JM, da-Cunha, EVL, Gray, AI (2000) Alkaloids of the Menispermaceae. In: Cordell, G. A. (ed.) The Alkaloids: Chemistry and Biology. Vol. 54, Chapter I. San Diego: Academic Press Inc., pp. 1\u2013190. https:\/\/doi.org\/10.1016\/S0099-9598(00)54002-4","DOI":"10.1016\/S0099-9598(00)54002-4"},{"key":"2498_CR6","unstructured":"Bohra, P., Waman, A. A. and Roy, S. D. Khoon phal (Haematocarpus validus (Miers.) Bakh. F. Ex Forman). CRP-AB\/Underutilized Species\/T.B.-01, ICAR-CIARI, Port Blair., 2016, pp. 1\u20138. https:\/\/www.researchgate.net\/profile\/Sibnarayan-Dam-Roy\/publication\/299330626_Khoon_Phal_Haematocarpus_validus_Miers_Bakh_F_ex_Forman\/links\/56f0d05d08aeedbe3ce44300\/Khoon-Phal-Haematocarpus-validus-Miers-Bakh-F-ex-Forman.pdf"},{"key":"2498_CR7","doi-asserted-by":"publisher","unstructured":"Bohra P, Waman AA, Basantia D, Devi HL, Reang E (2018) Domestication and conservation efforts in Haematocarpus validus (Miers.) Bakh. f. ex Forman (Menispermaceae): an underutilized fruit species and natural colourant. Curr Sci 115(6):1098\u20131105. https:\/\/doi.org\/10.18520\/cs\/v115\/i6\/1098-1105","DOI":"10.18520\/cs\/v115\/i6\/1098-1105"},{"issue":"1","key":"2498_CR8","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.jep.2011.05.048","volume":"137","author":"DP Chen","year":"2011","unstructured":"Chen DP, Wong CK, Leung PC, Fung KP, Lau CB, Lau CP, Li EK, Tam LS, Lam CW (2011) Anti-inflammatory activities of Chinese herbal medicine sinomenine and Liang Miao San on tumor necrosis factor-\u03b1-activated human fibroblast-like synoviocytes in rheumatoid arthritis. J Ethnopharmacol 137(1):457\u2013468. https:\/\/doi.org\/10.1016\/j.jep.2011.05.048","journal-title":"J Ethnopharmacol"},{"key":"2498_CR9","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.phytochem.2013.02.018","volume":"91","author":"DJ Cuthbertson","year":"2013","unstructured":"Cuthbertson DJ, Johnson SR, Piljac-Zegarac J, Kappel J, Schafer S, Wust M, Ketchum REB, Croteau RB, Marques JV, Davin LB, Lewis NG, Rolf M, Kutchan TM, Soejarto DD, Lange BM (2013) Accurate mass-time tag library for LC\/MS-based metabolite profiling of medicinal plans. Phytochem 91:187\u2013197. https:\/\/doi.org\/10.1016\/j.phytochem.2013.02.018","journal-title":"Phytochem"},{"key":"2498_CR10","doi-asserted-by":"publisher","unstructured":"Dasgupta S, Ray AB, Bhattacharya SK, Ray R (1979) Constituents of Pachygone ovate and pharmacological action of its major leaf alkaloid. J Nat Prod 42:399\u2013406. https:\/\/doi.org\/10.1021\/np50004a007","DOI":"10.1021\/np50004a007"},{"key":"2498_CR11","doi-asserted-by":"publisher","unstructured":"Deng F, Ma YX, Liang L, Zhang P, Feng J (2018) The pro-apoptosis effect of sinomenine in renal carcinoma via. inducing autophagy through inactivating PI3K\/AKT\/mTOR pathway. Biomed Pharmacother 97:1269\u20131274. https:\/\/doi.org\/10.1016\/j.biopha.2017.11.064","DOI":"10.1016\/j.biopha.2017.11.064"},{"issue":"12","key":"2498_CR12","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.bse.2004.04.003","volume":"32","author":"H DeWet","year":"2004","unstructured":"DeWet H, VanHeerden FR, VanWyk BE (2004) Alkaloids of Antizoma angustifolia (Menispermaceae). Biochem Syst Ecol 32(12):1145\u20131152. https:\/\/doi.org\/10.1016\/j.bse.2004.04.003","journal-title":"Biochem Syst Ecol"},{"issue":"8","key":"2498_CR13","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/j.bse.2004.12.014","volume":"33","author":"H DeWet","year":"2005","unstructured":"DeWet H, VanHeerden FR, VanWyk BE (2005) Alkaloids of Antizoma miersiana (Menispermaceae). Biochem Syst Ecol 33(8):799\u2013807. https:\/\/doi.org\/10.1016\/j.bse.2004.12.014","journal-title":"Biochem Syst Ecol"},{"key":"2498_CR14","unstructured":"Hajra PK, Rao PSN, Mudgal V (1999) Flora of Andaman and Nicobar Islands (Ranunculaceae to Combretaceae), vol. 1. Botanical Survey of India, India.\u00a0https:\/\/books.google.co.in\/books?id=FUpdzwEACAAJ"},{"key":"2498_CR15","doi-asserted-by":"publisher","unstructured":"Holmes, HL (1952) Sinomenine. In: Manske, R. H. F., Holmes, H. L., (eds.) The Alkaloids: Chemistry and Physiology Vol. II, Chapter IX. New York (NY): Academic Press Inc., pp. 219\u2013260. https:\/\/doi.org\/10.1016\/S1876-0813(08)60026-3","DOI":"10.1016\/S1876-0813(08)60026-3"},{"key":"2498_CR16","unstructured":"http:\/\/www.agilent.com\/chem\/metabolomics. Accessed 25 Jan 2018"},{"key":"2498_CR17","unstructured":"http:\/\/www.hmdb.ca\/metabolites\/HMDB60351. Accessed 25 Jan 2018"},{"key":"2498_CR18","unstructured":"https:\/\/www.drugbank.ca\/drugs\/DB00749. Accessed 25 Jan 2018"},{"key":"2498_CR19","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.ntt.2016.11.007","volume":"59","author":"NM Idrus","year":"2017","unstructured":"Idrus NM, Breit KR, Thomas JD (2017) Dietary Choline levels modify the effects of prenatal alcohol exposure in rats. Neurotoxicol Teratol 59:43\u201352. https:\/\/doi.org\/10.1016\/j.ntt.2016.11.007","journal-title":"Neurotoxicol Teratol"},{"key":"2498_CR20","doi-asserted-by":"publisher","unstructured":"Kang, JH, Kim, DJ, Choi, BK, Park, JW (2017) Inhibition of malodorous gas formation by oral bacteria with cetylpyridinium and zinc chloride. Arch Oral Biol, Article published online: 28\/09\/2017. https:\/\/doi.org\/10.1016\/j.archoralbio.2017.09.023","DOI":"10.1016\/j.archoralbio.2017.09.023"},{"issue":"3","key":"2498_CR21","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1002\/jps.2600620311","volume":"62","author":"WJ Keller","year":"1973","unstructured":"Keller WJ, McLaughlin JL, Brady LR (1973) Cactus alkaloids XV: \u03b2-phenethylamine derivatives from Coryphantha macromeris var runyonii. J Pharmaceut Sci 62(3):408\u2013411. https:\/\/doi.org\/10.1002\/jps.2600620311","journal-title":"J Pharmaceut Sci"},{"key":"2498_CR22","doi-asserted-by":"crossref","unstructured":"Khatun, MJM, Rahman, MM, Rahim, MA, Mirdah, MH (2014) Study on the taxonomy and nutritional status of Lalgula (Haematocarpus validus): a promising endemic ethnic fruit of Bangladesh. Int J Sust Agri Technol, 10(2), 1\u20134. https:\/\/scholar.google.com\/scholar?oi=bibs&cluster=11085809882841462509&btnI=1&hl=en","DOI":"10.5171\/2014.805309"},{"key":"2498_CR23","unstructured":"Kumar, K, Kumar, B, Selvun, T, Sajibala, B, Jairaj, RSC, Mehrotra, S Pushpangadan, P (2006) Ethnobotanical heritage of Nicobarese tribe. J Econ Taxon Bot, 30, 331\u2013348. https:\/\/www.researchgate.net\/publication\/315653667_Ethnobotanical_heritage_of_Nicobrese_tribe"},{"key":"2498_CR24","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1021\/np50099a005","volume":"56","author":"K Likhitwitayawuid","year":"1993","unstructured":"Likhitwitayawuid K, Angerhofer CK, Chai H, Pezzuto JM, Cordell GA, Ruangrungsi N (1993) Traditional medicinal plants of Thailand. XXIII. Cytotoxic and antimalarial alkaloids from the tubers of Stephania pierrei. J Nat Prod 56:1468\u20131478. https:\/\/doi.org\/10.1021\/np50099a005","journal-title":"J Nat Prod"},{"issue":"2","key":"2498_CR25","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s00210-008-0352-1","volume":"379","author":"MAA Medeiros","year":"2009","unstructured":"Medeiros MAA, Nunes XP, Barbosa-Filho JM, Lemos VS, Pinho JF, Roman-Campos D, deMedeiros IA, Araujo DAM, Cruz JS (2009) (S)-reticuline induces vasorelaxation through the blockade of L-type Ca2+ channels. Naunyn-Schmiedeberg\u2019s Arch Pharmacol 379(2):115\u2013125. https:\/\/doi.org\/10.1007\/s00210-008-0352-1","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"issue":"21","key":"2498_CR26","doi-asserted-by":"publisher","first-page":"7393","DOI":"10.1073\/pnas.0802981105","volume":"105","author":"H Minami","year":"2008","unstructured":"Minami H, Kim JS, Ikezawa N, Takemura T, Katayama T, Kumagai H, Sato F (2008) Microbial production of plant benzylisoquinoline alkaloids. Proceed Nat Acad Sci, USA 105(21):7393\u20137398. https:\/\/doi.org\/10.1073\/pnas.0802981105","journal-title":"Proceed Nat Acad Sci, USA"},{"issue":"12","key":"2498_CR27","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1177\/1934578X1200701234","volume":"7","author":"JJ Nair","year":"2012","unstructured":"Nair JJ, Bastida J, Viladomat F, vanStaden J (2012) Cytotoxic agents of the crinane series of Amaryllidaceae alkaloids. Nat Prod Commun 7(12):1677\u20131688. https:\/\/doi.org\/10.1177\/1934578X1200701234","journal-title":"Nat Prod Commun"},{"issue":"3","key":"2498_CR28","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1248\/bpb.22.268","volume":"22","author":"S Nawai","year":"1999","unstructured":"Nawai S, Ma C, Nakamura N, Hattori M, Kurokawa M, Shiraki K, Kashiwaba N, Ono M (1999) Anti-herpes simplex virus activity of alkaloids isolated from Stephania cepharantha. Biol Pharmaceut Bull 22(3):268\u2013274. https:\/\/doi.org\/10.1248\/bpb.22.268","journal-title":"Biol Pharmaceut Bull"},{"issue":"3","key":"2498_CR29","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.sdentj.2011.03.001","volume":"23","author":"N Pahwa","year":"2011","unstructured":"Pahwa N, Kumar A, Gupta S (2011) Short term clinical effectiveness of a 0.07% cetylpyridinium chloride mouth rinse in patients undergoing fixed orthodontic appliance treatment. Saudi Dent J 23(3):135\u2013141. https:\/\/doi.org\/10.1016\/j.sdentj.2011.03.001","journal-title":"Saudi Dent J"},{"key":"2498_CR30","doi-asserted-by":"publisher","DOI":"10.1201\/9780203013717","volume-title":"Anti-inflammatory, antioxidant and antidiabetic plant compounds. Chapter 14. In: Biochemical targets of plant bioactive compounds: a pharmacological reference guide to sites of action and biological effects","author":"G Polya","year":"2003","unstructured":"Polya G (2003) Anti-inflammatory, antioxidant and antidiabetic plant compounds. Chapter 14. In: Biochemical targets of plant bioactive compounds: a pharmacological reference guide to sites of action and biological effects. CRC Press, London. https:\/\/doi.org\/10.1201\/9780203013717"},{"key":"2498_CR31","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1742-2094-4-23","volume":"4","author":"L Qian","year":"2007","unstructured":"Qian L, Xu Z, Zhang W, Wilson B, Hong JS, Flood PM (2007) Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase. J Neuroinflammation 4:23. https:\/\/doi.org\/10.1186\/1742-2094-4-23","journal-title":"J Neuroinflammation"},{"issue":"10","key":"2498_CR32","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.1007\/s00203-020-01985-x","volume":"202","author":"R Sasikumar","year":"2020","unstructured":"Sasikumar R, Das D, Saravanan C, Deka SC (2020) GC-HRMS screening of bioactive compounds responsible for antimicrobial and antioxidant activities of blood fruit (Haematocarpus validus Bakh. F. Ex Forman) of North-East India. Arch Microbiol 202(10):2643\u20132654. https:\/\/doi.org\/10.1007\/s00203-020-01985-x","journal-title":"Arch Microbiol"},{"issue":"1","key":"2498_CR33","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1080\/15538362.2020.1848752","volume":"21","author":"R Sasikumar","year":"2021","unstructured":"Sasikumar R, Kambhampati V, Saravanan C, Sankar CD (2021) Physicochemical characterization and mass modeling of blood fruit (Haematocarpus validus)\u2013an underutilized fruit of northeastern India. Int J Fruit Sci 21(1):12\u201325. https:\/\/doi.org\/10.1080\/15538362.2020.1848752","journal-title":"Int J Fruit Sci"},{"issue":"5","key":"2498_CR34","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s40009-016-0483-8","volume":"39","author":"B Singh","year":"2016","unstructured":"Singh B, Bedi YS (2016) Rediscovery, taxonomic history and extended enumeration of Haematocarpus validus Bakh.f. ex Forman (Menispermaceae) to Indo-Myanmar biodiversity hotspot. Nat Acad Sci Lett 39(5):383\u2013387. https:\/\/doi.org\/10.1007\/s40009-016-0483-8","journal-title":"Nat Acad Sci Lett"},{"key":"2498_CR35","unstructured":"Singh, S. S., Pandey, S. C., Srivastava, S., Gupta, V. S., Patro, B. and Ghosh, A. C. (2003) Chemistry and medicinal properties of Tinospora cordifolia (Guduchi). Ind J Pharmacol, 35, 83\u201391. https:\/\/ijp-online.com\/article.asp?issn=0253-7613;year=2003;volume=35;issue=2;spage=83;epage=91;aulast=Singh;type=0"},{"key":"2498_CR36","doi-asserted-by":"publisher","unstructured":"Springob, K, Kutchan, TM (2009) Introduction to different classes of Natural Products. In: Osbourn, A. E. and Lanzotti, V. (eds.) Plant derived Natural Products: Synthesis, Function and Application. Springer, pp. 3\u201350. https:\/\/doi.org\/10.1007\/978-0-387-85498-4","DOI":"10.1007\/978-0-387-85498-4"},{"key":"2498_CR37","doi-asserted-by":"publisher","unstructured":"Wagner, H, Bauer, R, Melchart, D, Xiao, P, Staudinger, A (2011) Caulis sinomenii. Qingfengteng. In: Chromatographic fingerprint analysis of herbal medicines. Thin-layer and high performance liquid chromatography of chinese drugs, vol. 1. SpringerWien, New York (NY), pp 369\u2013380. https:\/\/doi.org\/10.1007\/978-3-7091-0763-8","DOI":"10.1007\/978-3-7091-0763-8"},{"issue":"7","key":"2498_CR38","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1055\/s-0028-1088393","volume":"75","author":"JL Wolfender","year":"2009","unstructured":"Wolfender JL (2009) HPLC in natural product analysis: the detection issue. Planta Med 75(7):719\u2013734. https:\/\/doi.org\/10.1055\/s-0028-1088393","journal-title":"Planta Med"},{"key":"2498_CR39","unstructured":"Yamasaki, H (1976) Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum. Acta Med Okayama, 30(1), 1\u201320. https:\/\/ousar.lib.okayama-u.ac.jp\/31433"},{"issue":"5","key":"2498_CR40","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1080\/07315724.1992.10718251","volume":"11","author":"SH Zeisel","year":"1992","unstructured":"Zeisel SH (1992) Choline: an important nutrient in brain development, liver function and carcinogenesis. J Am Colle Nutri 11(5):473\u2013481. https:\/\/doi.org\/10.1080\/07315724.1992.10718251","journal-title":"J Am Colle Nutri"},{"issue":"11","key":"2498_CR41","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1111\/j.1753-4887.2009.00246.x","volume":"67","author":"SH Zeisel","year":"2009","unstructured":"Zeisel SH, daCosta KA (2009) Choline: an essential nutrient for public health. Nutri Rev 67(11):615\u2013623. https:\/\/doi.org\/10.1111\/j.1753-4887.2009.00246.x","journal-title":"Nutri Rev"},{"issue":"8","key":"2498_CR42","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.3109\/13880209.2012.656847","volume":"50","author":"XX Zhao","year":"2012","unstructured":"Zhao XX, Peng C, Zhang H, Qin LP (2012) Sinomenium acutum: a review of chemistry, pharmacology, pharmacokinetics and clinical use. Pharm Biol 50(8):1053\u20131061. https:\/\/doi.org\/10.3109\/13880209.2012.656847","journal-title":"Pharm Biol"}],"updated-by":[{"DOI":"10.1007\/s00210-024-03084-w","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000}}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-023-02498-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-023-02498-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-023-02498-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T04:04:53Z","timestamp":1712894693000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-023-02498-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,3]]},"references-count":42,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["2498"],"URL":"https:\/\/doi.org\/10.1007\/s00210-023-02498-2","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,3]]},"assertion":[{"value":"20 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00210-024-03084-w","URL":"https:\/\/doi.org\/10.1007\/s00210-024-03084-w","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors give consent for the publication of this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}