{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:23:59Z","timestamp":1793381039196,"version":"4.5.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T00:00:00Z","timestamp":1685145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T00:00:00Z","timestamp":1685145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Bonn"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mast cells (MCs) occupy a central role in immunological as well as non-immunological processes as reflected in the variety of the mediators by which MCs influence other cells. Published lists of MC mediators have all shown only subsets\u2014usually quite small\u2014of the full repertoire. The full repertoire of MC mediators released by exocytosis is comprehensively compiled here for the first time. The compilation of the data is essentially based on the largely cytokine-focused database <jats:italic>COPE<\/jats:italic><jats:sup><jats:italic>\u00ae<\/jats:italic><\/jats:sup>, supplemented with data on the expression of substances in human MCs published in several articles, plus extensive research in the PubMed database. Three hundred and ninety substances could be identified as mediators of human MCs which can be secreted into the extracellular space by activation of the MC. This number might still be an underestimate of the actual number of MC mediators since, in principle, all substances produced by MCs can become mediators because of the possibility of their release by diffusion into the extracellular space, mast cell extracellular traps, and intercellular exchange via nanotubules. When human MCs release mediators in inappropriate manners, this may lead to symptoms in any or all organs\/tissues. Thus, such MC activation disorders may clinically present with a myriad of potential combinations of symptoms ranging from trivial to disabling or even life-threatening. The present compilation can be consulted by physicians when trying to gain clarity about MC mediators which may be involved in patients with MC disease symptoms refractory to most therapies.<\/jats:p>","DOI":"10.1007\/s00210-023-02545-y","type":"journal-article","created":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T08:02:02Z","timestamp":1685174522000},"page":"2881-2891","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["A survey of the currently known mast cell mediators with potential relevance for therapy of mast cell-induced symptoms"],"prefix":"10.1007","volume":"396","author":[{"given":"Gerhard J.","family":"Molderings","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence B.","family":"Afrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,27]]},"reference":[{"key":"2545_CR1","doi-asserted-by":"publisher","first-page":"190","DOI":"10.3109\/07853890.2016.1161231","volume":"48","author":"LB Afrin","year":"2016","unstructured":"Afrin LB, Butterfield JH, Raithel M, Molderings GJ (2016) Often seen, rarely recognized: mast cell activation disease--a guide to diagnosis and therapeutic options. Ann Med 48:190\u2013201. https:\/\/doi.org\/10.3109\/07853890.2016.1161231","journal-title":"Ann Med"},{"key":"2545_CR2","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.3390\/cancers14122944","volume":"14","author":"E Ahani","year":"2022","unstructured":"Ahani E, Fereydouni M, Motaghed M, Kepley CL (2022) Identification and characterization of tunneling nanotubes involved in human mast cell Fc\u03b5RI-mediated apoptosis of cancer cells. Cancers (Basel) 14:2944. https:\/\/doi.org\/10.3390\/cancers14122944","journal-title":"Cancers (Basel)"},{"key":"2545_CR3","doi-asserted-by":"publisher","first-page":"e48934","DOI":"10.1371\/journal.pone.0048934","volume":"7","author":"KD Alysandratos","year":"2012","unstructured":"Alysandratos KD, Asadi S, Angelidou A, Zhang B, Sismanopoulos N, Yang H, Critchfield A, Theoharides TC (2012) Neurotensin and CRH interactions augment human mast cell activation. Plos One 7:e48934. https:\/\/doi.org\/10.1371\/journal.pone.0048934","journal-title":"Plos One"},{"key":"2545_CR4","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1189\/jlb.0403157","volume":"75","author":"M Babina","year":"2004","unstructured":"Babina M, Guhl S, St\u00e4rke A, Kirchhof L, Zuberbier T, Henz BM (2004) Comparative cytokine profile of human skin mast cells from two compartments--strong resemblance with monocytes at baseline but induction of IL-5 by IL-4 priming. J Leukoc Biol 75:244\u2013252. https:\/\/doi.org\/10.1189\/jlb.0403157","journal-title":"J Leukoc Biol"},{"key":"2545_CR5","doi-asserted-by":"publisher","first-page":"27190","DOI":"10.1074\/jbc.M602359200","volume":"281","author":"I Bachelet","year":"2006","unstructured":"Bachelet I, Munitz A, Mankutad D, Levi-Schaffer F (2006) Mast cell costimulation by CD226\/CD112 (DNAM-1\/Nectin-2): a novel interface in the allergic process. J Biol Chem 281:27190\u201327196. https:\/\/doi.org\/10.1074\/jbc.M602359200","journal-title":"J Biol Chem"},{"key":"2545_CR6","doi-asserted-by":"publisher","first-page":"3315","DOI":"10.1074\/jbc.272.6.3315","volume":"272","author":"T Bisogno","year":"1997","unstructured":"Bisogno T, Maurelli S, Melck D, De Petrocellis L, Di Marzo V (1997) Biosynthesis, uptake, and degradation of anandamide and palmitoylethanolamide in leukocytes. J Biol Chem 272:3315\u20133323. https:\/\/doi.org\/10.1074\/jbc.272.6.3315","journal-title":"J Biol Chem"},{"key":"2545_CR7","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.3390\/cells10061282","volume":"10","author":"M Braile","year":"2021","unstructured":"Braile M, Marcella S, Marone G, Galdiero MR, Varricchi G, Loffredo S (2021) The interplay between the immune and the endocannabinoid systems in cancer. Cells 10:1282. https:\/\/doi.org\/10.3390\/cells10061282","journal-title":"Cells"},{"key":"2545_CR8","doi-asserted-by":"publisher","first-page":"46","DOI":"10.3389\/fimmu.2012.00046","volume":"3","author":"A Carroll-Portillo","year":"2012","unstructured":"Carroll-Portillo A, Surviladze Z, Cambi A, Lidke DS, Wilson BS (2012) Mast cell synapses and exosomes: membrane contacts for information exchange. Front Immunol 3:46. https:\/\/doi.org\/10.3389\/fimmu.2012.00046","journal-title":"Front Immunol"},{"key":"2545_CR9","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.freeradbiomed.2006.12.007","volume":"42","author":"K Chen","year":"2007","unstructured":"Chen K, Popel AS (2007) Vascular and perivascular nitric oxide release and transport: biochemical pathways of neuronal nitric oxide synthase (NOS1) and endothelial nitric oxide synthase (NOS3). Free Radic Biol Med 42:811\u2013822. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2006.12.007 PMID: 17320763","journal-title":"Free Radic Biol Med"},{"key":"2545_CR10","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/978-1-4939-1568-2_2","volume":"1220","author":"E Crivellato","year":"2015","unstructured":"Crivellato E, Travan L, Ribatti D (2015) The phylogenetic profile of mast cells. Methods Mol Biol 1220:11\u201327. https:\/\/doi.org\/10.1007\/978-1-4939-1568-2_2","journal-title":"Methods Mol Biol"},{"key":"2545_CR11","doi-asserted-by":"publisher","first-page":"73","DOI":"10.3389\/fimmu.2015.00073","volume":"6","author":"F D\u2019Inc\u00e0","year":"2015","unstructured":"D\u2019Inc\u00e0 F, Pucillo CE (2015) Exosomes: tiny clues for mast cell communication. Front Immunol 6:73. https:\/\/doi.org\/10.3389\/fimmu.2015.00073 PMID: 25741344","journal-title":"Front Immunol"},{"key":"2545_CR12","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.nano.2010.01.008","volume":"6","author":"A Dellinger","year":"2010","unstructured":"Dellinger A, Zhou Z, Norton SK, Lenk R, Conrad D, Kepley CL (2010) Uptake and distribution of fullerenes in human mast cells. Nanomed 6:575\u2013582. https:\/\/doi.org\/10.1016\/j.nano.2010.01.008","journal-title":"Nanomed"},{"key":"2545_CR13","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1159\/000086516","volume":"85","author":"AM Dvorak","year":"2005","unstructured":"Dvorak AM (2005) Piecemeal degranulation of basophils and mast cells is effected by vesicular transport of stored secretory granule contents. Chem Immunol Allergy 85:135\u2013184. https:\/\/doi.org\/10.1159\/000086516","journal-title":"Chem Immunol Allergy"},{"key":"2545_CR14","doi-asserted-by":"publisher","unstructured":"Ekstr\u00f6m K, Valadi H, Sj\u00f6strand M, Malmh\u00e4ll C, Bossios A, Eldh M, L\u00f6tvall J (2012) Characterization of mRNA and microRNA in human mast cell-derived exosomes and their transfer to other mast cells and blood CD34 progenitor cells. J Extracell Vesicles 1:18389. https:\/\/doi.org\/10.3402\/jev.v1i0.18389","DOI":"10.3402\/jev.v1i0.18389"},{"key":"2545_CR15","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1111\/j.1398-9995.2010.02494.x","volume":"66","author":"M Elishmereni","year":"2011","unstructured":"Elishmereni M, Alenius HT, Bradding P, Mizrahi S, Shikotra A, Minai-Fleminger Y, Mankuta D, Eliashar R, Zabucchi G, Levi-Schaffer F (2011) Physical interactions between mast cells and eosinophils: a novel mechanism enhancing eosinophil survival in vitro. Allergy 66:376\u2013385. https:\/\/doi.org\/10.1111\/j.1398-9995.2010.02494.x","journal-title":"Allergy"},{"key":"2545_CR16","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1083\/jcb.135.1.279","volume":"135","author":"DS Friend","year":"1996","unstructured":"Friend DS, Ghildyal N, Austen KF, Gurish MF, Matsumoto R, Stevens RL (1996) Mast cells that reside at different locations in the jejunum of mice infected with Trichinella spiralis exhibit sequential changes in their granule ultrastructure and chymase phenotype. J Cell Biol 135:279\u2013290. https:\/\/doi.org\/10.1083\/jcb.135.1.279","journal-title":"J Cell Biol"},{"key":"2545_CR17","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1002\/iid3.295","volume":"8","author":"KM Garcia-Rodriguez","year":"2020","unstructured":"Garcia-Rodriguez KM, Bahri R, Sattentau C, Roberts IS, Goenka A, Bulfone-Paus S (2020) Human mast cells exhibit an individualized pattern of antimicrobial responses. Immun Inflamm Dis 8:198\u2013210. https:\/\/doi.org\/10.1002\/iid3.295","journal-title":"Immun Inflamm Dis"},{"key":"2545_CR18","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3389\/fimmu.2012.00120","volume":"3","author":"G Gri","year":"2012","unstructured":"Gri G, Frossi B, D'Inca F, Danelli L, Betto E, Mion F, Sibilano R, Pucillo C (2012) Mast cell: an emerging partner in immune interaction. Front Immunol 3:120. https:\/\/doi.org\/10.3389\/fimmu.2012.00120 PMID: 22654879","journal-title":"Front Immunol"},{"key":"2545_CR19","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s12026-013-8391-1","volume":"56","author":"B Haenisch","year":"2013","unstructured":"Haenisch B, Herms S, Molderings GJ (2013) The transcriptome of the human mast cell leukemia cells HMC-1.2: an approach to identify specific changes in the gene expression profile in KITD816V systemic mastocytosis. Immunol Res 56:155\u2013162. https:\/\/doi.org\/10.1007\/s12026-013-8391-1","journal-title":"Immunol Res"},{"key":"2545_CR20","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.healun.2019.01.1317","volume":"38","author":"KM Halloran","year":"2019","unstructured":"Halloran KM, Parkes MD, Chang J, Timofte IL, Snell GI, Westall GP, Hachem R, Kreisel D, Trulock E, Roux A, Juvet S, Keshavjee S, Jaksch P, Klepetko W, Halloran PF (2019) Molecular assessment of rejection and injury in lung transplant biopsies. J Heart Lung Transplant 38:504\u2013513. https:\/\/doi.org\/10.1016\/j.healun.2019.01.1317","journal-title":"J Heart Lung Transplant"},{"key":"2545_CR21","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/s0006-2952(02)01651-9","volume":"65","author":"S He","year":"2003","unstructured":"He S, McEuen AR, Blewett SA, Li P, Buckley MG, Leufkens P, Walls AF (2003) The inhibition of mast cell activation by neutrophil lactoferrin: uptake by mast cells and interaction with tryptase, chymase and cathepsin G. Biochem Pharmacol 65:1007\u20131015. https:\/\/doi.org\/10.1016\/s0006-2952(02)01651-9","journal-title":"Biochem Pharmacol"},{"key":"2545_CR22","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.2174\/156652412803833544","volume":"12","author":"S He","year":"2012","unstructured":"He S, Zhang H, Zeng X, Yang P (2012) Self-amplification mechanisms of mast cell activation: a new look in allergy. Curr Mol Med 12:1329\u20131339. https:\/\/doi.org\/10.2174\/156652412803833544","journal-title":"Curr Mol Med"},{"key":"2545_CR23","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.bbrc.2019.09.126","volume":"520","author":"N Higashi","year":"2019","unstructured":"Higashi N, Maeda R, Sesoko N, Isono M, Ishikawa S, Tani Y, Takahashi K, Oku T, Higashi K, Onishi S, Nakajima M, Irimura T (2019) Chondroitin sulfate E blocks enzymatic action of heparanase and heparanase-induced cellular responses. Biochem Biophys Res Commun 520:152\u2013158. https:\/\/doi.org\/10.1016\/j.bbrc.2019.09.126","journal-title":"Biochem Biophys Res Commun"},{"issue":"Suppl 1","key":"2545_CR24","doi-asserted-by":"publisher","first-page":"S03","DOI":"10.1007\/s000110300028","volume":"52","author":"Z Huszti","year":"2003","unstructured":"Huszti Z (2003) Histamine uptake into non-neuronal brain cells. Inflamm Res 52(Suppl 1):S03\u2013S06. https:\/\/doi.org\/10.1007\/s000110300028","journal-title":"Inflamm Res"},{"key":"2545_CR25","unstructured":"Ibelgaufts H (2023) COPE -Cytokines & Cells Online Pathfinder Encyclopaedia. http:\/\/www.cells-talk.com\/index.php\/page\/about. Last accessed March 2023"},{"key":"2545_CR26","doi-asserted-by":"publisher","first-page":"111346","DOI":"10.1016\/j.celrep.2022.111346","volume":"40","author":"JA Iskarpatyoti","year":"2022","unstructured":"Iskarpatyoti JA, Shi J, Abraham MA, Rathore APS, Miao Y, Abraham SN (2022) Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter. Cell Rep 40:111346. https:\/\/doi.org\/10.1016\/j.celrep.2022.111346","journal-title":"Cell Rep"},{"key":"2545_CR27","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/1471-2164-7-210","volume":"7","author":"M Jayapal","year":"2006","unstructured":"Jayapal M, Tay HK, Reghunathan R, Zhi L, Chow KK, Rauff M, Melendez AJ (2006) Genome-wide gene expression profiling of human mast cells stimulated by IgE or FcepsilonRI-aggregation reveals a complex network of genes involved in inflammatory responses. BMC Genomics 7:210. https:\/\/doi.org\/10.1186\/1471-2164-7-210","journal-title":"BMC Genomics"},{"key":"2545_CR28","doi-asserted-by":"publisher","first-page":"2755","DOI":"10.4049\/jimmunol.177.5.2755","volume":"177","author":"Y Jiang","year":"2006","unstructured":"Jiang Y, Kanaoka Y, Feng C, Nocka K, Rao S, Boyce JA (2006) Cutting edge: Interleukin 4-dependent mast cell proliferation requires autocrine\/intracrine cysteinyl leukotriene-induced signaling. J Immunol 177:2755\u20132759. https:\/\/doi.org\/10.4049\/jimmunol.177.5.2755","journal-title":"J Immunol"},{"key":"2545_CR29","doi-asserted-by":"publisher","first-page":"E10692","DOI":"10.1073\/pnas.1809938115","volume":"115","author":"DK Kim","year":"2018","unstructured":"Kim DK, Cho YE, Komarow HD, Bandara G, Song BJ, Olivera A, Metcalfe DD (2018) Mastocytosis-derived extracellular vesicles exhibit a mast cell signature, transfer KIT to stellate cells, and promote their activation. Proc Natl Acad Sci U S A 115:E10692\u2013E10701. https:\/\/doi.org\/10.1073\/pnas.1809938115","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2545_CR30","doi-asserted-by":"publisher","first-page":"9542656","DOI":"10.1155\/2019\/9542656","volume":"2019","author":"O Klein","year":"2019","unstructured":"Klein O, Sagi-Eisenberg R (2019) Anaphylactic degranulation of mast cells: focus on compound exocytosis. J Immunol Res 2019:9542656. https:\/\/doi.org\/10.1155\/2019\/9542656","journal-title":"J Immunol Res"},{"key":"2545_CR31","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.ejphar.2015.04.050","volume":"778","author":"E Kritikou","year":"2016","unstructured":"Kritikou E, Kuiper J, Kovanen PT, Bot I (2016) The impact of mast cells on cardiovascular diseases. Eur J Pharmacol 778:103\u2013115. https:\/\/doi.org\/10.1016\/j.ejphar.2015.04.050","journal-title":"Eur J Pharmacol"},{"key":"2545_CR32","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1159\/000453068","volume":"023","author":"DD Le","year":"2016","unstructured":"Le DD, Schmit D, Heck S, Omlor AJ, Sester M, Herr C, Schick B, Daubeuf F, F\u00e4hndrich S, Bals R, Frossard N, Al Kadah B, Dinh QT (2016) Increase of mast cell-nerve association and neuropeptide receptor expression on mast cells in perennial allergic rhinitis. Neuroimmunomodulation 023:261\u2013270. https:\/\/doi.org\/10.1159\/000453068","journal-title":"Neuroimmunomodulation"},{"key":"2545_CR33","first-page":"352","volume":"10","author":"Y Liang","year":"2018","unstructured":"Liang Y, Qiao L, Peng X, Cui Z, Yin Y, Liao H, Jiang M, Li L (2018) The chemokine receptor CCR1 is identified in mast cell-derived exosomes. Am J Transl Res 10:352\u2013367","journal-title":"Am J Transl Res"},{"key":"2545_CR34","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1007\/s00018-010-0587-0","volume":"68","author":"A Lundequist","year":"2011","unstructured":"Lundequist A, Pejler G (2011) Biological implications of preformed mast cell mediators. Cell Mol Life Sci 68:965\u2013975. https:\/\/doi.org\/10.1007\/s00018-010-0587-0","journal-title":"Cell Mol Life Sci"},{"key":"2545_CR35","unstructured":"Maitland A, Brock I, Reed W (2020) Immune dysfunction, both mast cell activation disorders and primary immune deficiency, is common among patients with hypermobile spectrum disorder (HSD) or hypermobile type Ehlers Danlos Syndrome (hEDS). In Proceedings of the EDS ECHO Summit, October 2, 2020; session 12, poster number 001, available online: https:\/\/www.ehlers-danlos.com\/wp-content\/uploads\/2020\/09\/Poster-001-FINAL-A-Maitland-et-al-EDS-ECHO-SUMMIT-Oct-2020.pdf"},{"key":"2545_CR36","doi-asserted-by":"publisher","first-page":"6192","DOI":"10.1073\/pnas.81.19.6192","volume":"81","author":"DL Marquardt","year":"1984","unstructured":"Marquardt DL, Gruber HE, Wasserman SI (1984) Adenosine release from stimulated mast cells. Proc Natl Acad Sci U S A 81:6192\u20136196. https:\/\/doi.org\/10.1073\/pnas.81.19.6192","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2545_CR37","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1016\/j.bbagen.2018.01.020","volume":"1862","author":"C McHale","year":"2018","unstructured":"McHale C, Mohammed Z, Deppen J, Gomez G (2018) Interleukin-6 potentiates Fc\u03b5RI-induced PGD2 biosynthesis and induces VEGF from human in situ-matured skin mast cells. Biochim Biophys Acta Gen Subj 1862:1069\u20131078. https:\/\/doi.org\/10.1016\/j.bbagen.2018.01.020","journal-title":"Biochim Biophys Acta Gen Subj"},{"issue":"23","key":"2545_CR38","doi-asserted-by":"publisher","first-page":"00511-0","DOI":"10.1016\/j.jaci.2023.04.007","volume":"S0091-6749","author":"I Miralda","year":"2023","unstructured":"Miralda I, Samanas NB, Seo AJ, Foronda JS, Sachen J, Hui Y, Morrison SD, Oskeritzian CA, Piliponsky AM (2023) Siglec-9 is an inhibitory receptor on human mast cells in vitro. J Allergy Clin Immunol S0091-6749(23):00511-0. https:\/\/doi.org\/10.1016\/j.jaci.2023.04.007","journal-title":"J Allergy Clin Immunol"},{"key":"2545_CR39","doi-asserted-by":"publisher","first-page":"110862","DOI":"10.1016\/j.mehy.2022.110862","volume":"163","author":"GJ Molderings","year":"2022","unstructured":"Molderings GJ (2022) Systemic mast cell activation disease variants and certain genetically determined comorbidities may be consequences of a common underlying epigenetic disease. Med Hypotheses 163:110862. https:\/\/doi.org\/10.1016\/j.mehy.2022.110862","journal-title":"Med Hypotheses"},{"key":"2545_CR40","doi-asserted-by":"publisher","first-page":"e76241","DOI":"10.1371\/journal.pone.0076241","volume":"8","author":"GJ Molderings","year":"2013","unstructured":"Molderings GJ, Haenisch B, Bogdanow M, Fimmers R, N\u00f6then MM (2013) Familial occurrence of systemic mast cell activation disease. Plos One 8:e76241. https:\/\/doi.org\/10.1371\/journal.pone.0076241","journal-title":"Plos One"},{"key":"2545_CR41","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1007\/s00210-016-1247-1","volume":"389","author":"GJ Molderings","year":"2016","unstructured":"Molderings GJ, Haenisch B, Brettner S, Homann J, Menzen M, Dumoulin FL, Panse J, Butterfield J, Afrin LB (2016) Pharmacological treatment options for mast cell activation disease. Naunyn Schmiedeberg's Arch Pharmacol 389:671\u2013694. https:\/\/doi.org\/10.1007\/s00210-016-1247-1 Epub 2016 Apr 30","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"2545_CR42","doi-asserted-by":"publisher","first-page":"265","DOI":"10.3389\/fimmu.2016.00265","volume":"7","author":"H M\u00f6llerherm","year":"2016","unstructured":"M\u00f6llerherm H, von K\u00f6ckritz-Blickwede M, Branitzki-Heinemann K (2016) Antimicrobial activity of mast cells: role and relevance of extracellular DNA traps. Front Immunol 7:265. https:\/\/doi.org\/10.3389\/fimmu.2016.00265","journal-title":"Front Immunol"},{"key":"2545_CR43","doi-asserted-by":"publisher","first-page":"569","DOI":"10.3389\/fimmu.2014.00569","volume":"5","author":"TC Moon","year":"2014","unstructured":"Moon TC, Befus AD, Kulka M (2014) Mast cell mediators: their differential release and the secretory pathways involved. Front Immunol 5:569. https:\/\/doi.org\/10.3389\/fimmu.2014.00569","journal-title":"Front Immunol"},{"key":"2545_CR44","doi-asserted-by":"publisher","first-page":"e58","DOI":"10.1182\/blood-2013-02-483792","volume":"123","author":"E Motakis","year":"2014","unstructured":"Motakis E, Guhl S, Ishizu Y, Itoh M, Kawaji H, de Hoon M, Lassmann T, Carninci P, Hayashizaki Y, Zuberbier T, Forrest AR, Babina M, FANTOM consortium (2014) Redefinition of the human mast cell transcriptome by deep-CAGE sequencing. Blood 123:e58\u2013e67. https:\/\/doi.org\/10.1182\/blood-2013-02-483792","journal-title":"Blood"},{"key":"2545_CR45","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1177\/039463200902200224","volume":"22","author":"N Niederhoffer","year":"2009","unstructured":"Niederhoffer N, Levy R, Sick E, Andre P, Coupin G, Lombard Y, Gies JP (2009) Amyloid beta peptides trigger CD47-dependent mast cell secretory and phagocytic responses. Int J Immunopathol Pharmacol 22:473\u2013483. https:\/\/doi.org\/10.1177\/039463200902200224","journal-title":"Int J Immunopathol Pharmacol"},{"key":"2545_CR46","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1189\/jlb.3HI1215-542R","volume":"100","author":"T Noordenbos","year":"2016","unstructured":"Noordenbos T, Blijdorp I, Chen S, Stap J, Mul E, Ca\u00f1ete JD, Lubberts E, Yeremenko N, Baeten D (2016) Human mast cells capture, store, and release bioactive, exogenous IL-17A. J Leukoc Biol 100:453\u2013462. https:\/\/doi.org\/10.1189\/jlb.3HI1215-542R","journal-title":"J Leukoc Biol"},{"key":"2545_CR47","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1111\/apm.13264","volume":"130","author":"K Norrby","year":"2022","unstructured":"Norrby K (2022) Do mast cells contribute to the continued survival of vertebrates? APMIS 130:618\u2013624. https:\/\/doi.org\/10.1111\/apm.13264 PMID: 35869669","journal-title":"APMIS"},{"key":"2545_CR48","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1159\/000087574","volume":"87","author":"Y Okayama","year":"2005","unstructured":"Okayama Y (2005) Mast cell-derived cytokine expression induced via Fc receptors and Toll-like receptors. Chem Immunol Allergy 87:101\u2013110. https:\/\/doi.org\/10.1159\/000087574","journal-title":"Chem Immunol Allergy"},{"key":"2545_CR49","doi-asserted-by":"publisher","first-page":"4193","DOI":"10.1182\/blood-2007-09-115451","volume":"111","author":"CA Oskeritzian","year":"2008","unstructured":"Oskeritzian CA, Alvarez SE, Hait NC, Price MM, Milstien S, Spiegel S (2008) Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions. Blood 111:4193\u20134200. https:\/\/doi.org\/10.1182\/blood-2007-09-115451","journal-title":"Blood"},{"key":"2545_CR50","doi-asserted-by":"publisher","first-page":"16477","DOI":"10.1074\/jbc.M705822200","volume":"283","author":"S Paruchuri","year":"2008","unstructured":"Paruchuri S, Jiang Y, Feng C, Francis SA, Plutzky J, Boyce JA (2008) Leukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cells. J Biol Chem 283:16477\u201316487. https:\/\/doi.org\/10.1074\/jbc.M705822200","journal-title":"J Biol Chem"},{"key":"2545_CR51","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1182\/blood-2012-12-469882","volume":"122","author":"WM Peng","year":"2013","unstructured":"Peng WM, Maintz L, Allam JP, Raap U, G\u00fctgemann I, Kirfel J, Wardelmann E, Perner S, Zhao W, Fimmers R, Walgenbach K, Oldenburg J, Schwartz LB, Novak N (2013) Increased circulating levels of neurotrophins and elevated expression of their high-affinity receptors on skin and gut mast cells in mastocytosis. Blood 122:1779\u20131788. https:\/\/doi.org\/10.1182\/blood-2012-12-469882","journal-title":"Blood"},{"key":"2545_CR52","doi-asserted-by":"publisher","first-page":"e12272","DOI":"10.1002\/jev2.12272","volume":"11","author":"A Pfeiffer","year":"2022","unstructured":"Pfeiffer A, Petersen JD, Falduto GH, Anderson DE, Zimmerberg J, Metcalfe DD, Olivera A (2022) Selective immunocapture reveals neoplastic human mast cells secrete distinct microvesicle- and exosome-like populations of KIT-containing extracellular vesicles. J Extracell Vesicles 11:e12272. https:\/\/doi.org\/10.1002\/jev2.12272","journal-title":"J Extracell Vesicles"},{"key":"2545_CR53","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1002\/stem.523","volume":"28","author":"S Poglio","year":"2010","unstructured":"Poglio S, De Toni-Costes F, Arnaud E, Laharrague P, Espinosa E, Casteilla L, Cousin B (2010) Adipose tissue as a dedicated reservoir of functional mast cell progenitors. Stem Cells 28:2065\u20132072. https:\/\/doi.org\/10.1002\/stem.523","journal-title":"Stem Cells"},{"key":"2545_CR54","first-page":"R87","volume":"358","author":"T Reinheimer","year":"1998","unstructured":"Reinheimer T, Vogel P, Rack\u00e9 K, Bittinger F, Kirkpatrick CJ, Saloga J, Knop J, Wessler I (1998) Non-neuronal acetylcholine is increased in chronic inflammation like atopic dermatitis. Naunyn-Schmiedeberg\u2019s Arch Pharmacol (Suppl) 358:R87","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol (Suppl)"},{"key":"2545_CR55","doi-asserted-by":"publisher","first-page":"1139397","DOI":"10.3389\/fmed.2023.1139397","volume":"10","author":"A Savage","year":"2023","unstructured":"Savage A, Risquez C, Gomi K, Schreiner R, Borczuk AC, Worgall S, Silver RB (2023) The mast cell exosome-fibroblast connection: a novel pro-fibrotic pathway. Front Med (Lausanne) 10:1139397. https:\/\/doi.org\/10.3389\/fmed.2023.1139397","journal-title":"Front Med (Lausanne)"},{"key":"2545_CR56","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1165\/ajrcmb.20.3.3387","volume":"20","author":"ES Schulman","year":"1999","unstructured":"Schulman ES, Glaum MC, Post T, Wang Y, Raible DG, Mohanty J, Butterfield JH, Pelleg A (1999) ATP modulates anti-IgE-induced release of histamine from human lung mast cells. Am J Respir Cell Mol Biol 20:530\u2013537. https:\/\/doi.org\/10.1165\/ajrcmb.20.3.3387","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2545_CR57","doi-asserted-by":"publisher","first-page":"9176","DOI":"10.3390\/ijms22179176","volume":"22","author":"I Shefler","year":"2021","unstructured":"Shefler I, Salamon P, Mekori YA (2021) Extracellular vesicles as emerging players in intercellular communication: relevance in mast cell-mediated pathophysiology. Int J Mol Sci 22:9176. https:\/\/doi.org\/10.3390\/ijms22179176","journal-title":"Int J Mol Sci"},{"key":"2545_CR58","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/297229a0","volume":"297","author":"TC Theoharides","year":"1982","unstructured":"Theoharides TC, Bondy PK, Tsakalos ND, Askenase PW (1982) Differential release of serotonin and histamine from mast cells. Nature 297:229\u2013231. https:\/\/doi.org\/10.1038\/297229a0","journal-title":"Nature"},{"key":"2545_CR59","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1126\/science.684435","volume":"201","author":"TC Theoharides","year":"1978","unstructured":"Theoharides TC, Douglas WW (1978) Secretion in mast cells induced by calcium entrapped within phospholipid vesicles. Science 201:1143\u20131145. https:\/\/doi.org\/10.1126\/science.684435","journal-title":"Science"},{"key":"2545_CR60","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1111\/j.1600-065X.2007.00519.x","volume":"217","author":"TC Theoharides","year":"2007","unstructured":"Theoharides TC, Kempuraj D, Tagen M, Conti P, Kalogeromitros D (2007) Differential release of mast cell mediators and the pathogenesis of inflammation. Immunol Rev 217:65\u201378. https:\/\/doi.org\/10.1111\/j.1600-065X.2007.00519.x","journal-title":"Immunol Rev"},{"key":"2545_CR61","doi-asserted-by":"publisher","unstructured":"Theoharides TC, Perlman AI, Twahir A, Kempuraj D (2023) Mast cell activation: beyond histamine and tryptase. Expert Rev Clin Immunol 1-16. https:\/\/doi.org\/10.1080\/1744666X.2023.2200936. Epub ahead of print","DOI":"10.1080\/1744666X.2023.2200936"},{"key":"2545_CR62","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s00281-016-0564-2","volume":"38","author":"SH Tsai","year":"2016","unstructured":"Tsai SH, Takeda K (2016) Regulation of allergic inflammation by the ectoenzyme E-NPP3 (CD203c) on basophils and mast cells. Semin Immunopathol 38:571\u2013579. https:\/\/doi.org\/10.1007\/s00281-016-0564-2","journal-title":"Semin Immunopathol"},{"key":"2545_CR63","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1007\/s10620-020-06264-9","volume":"66","author":"LB Weinstock","year":"2021","unstructured":"Weinstock LB, Pace LA, Rezaie A, Afrin LB, Molderings GJ (2021) Mast cell activation syndrome: a primer for the gastroenterologist. Dig Dis Sci 66:965\u2013982. https:\/\/doi.org\/10.1007\/s10620-020-06264-9","journal-title":"Dig Dis Sci"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-023-02545-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-023-02545-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-023-02545-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T06:13:23Z","timestamp":1697004803000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-023-02545-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,27]]},"references-count":63,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["2545"],"URL":"https:\/\/doi.org\/10.1007\/s00210-023-02545-y","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,27]]},"assertion":[{"value":"9 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Dr. Molderings is chief medical officer of the start-up company <i>MC Sciences, Ltd<\/i>. Dr. Afrin is an uncompensated volunteer medical advisor to the start-up company <i>MC Sciences Ltd<\/i>.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}