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Thus, we hypothesized that LSD might act 5-HT\n                    <jats:sub>4<\/jats:sub>\n                    serotonin receptors and\/or H\n                    <jats:sub>2<\/jats:sub>\n                    histamine receptors. We studied isolated electrically stimulated left atrial preparations, spontaneously beating right atrial preparations, and spontaneously beating Langendorff-perfused hearts from transgenic mice with cardiomyocyte-specific overexpression of the human 5-HT\n                    <jats:sub>4<\/jats:sub>\n                    receptor (5-HT\n                    <jats:sub>4<\/jats:sub>\n                    -TG) or of the H\n                    <jats:sub>2<\/jats:sub>\n                    -histamine receptor (H\n                    <jats:sub>2<\/jats:sub>\n                    -TG). For comparison, we used wild type littermate mice (WT). Finally, we measured isometric force of contraction in isolated electrically stimulated muscle strips from the human right atrium obtained from patients during bypass surgery. LSD (up to 10\u00a0\u00b5M) concentration dependently increased force of contraction and beating rate in left or right atrial preparations from 5-HT\n                    <jats:sub>4<\/jats:sub>\n                    -TG (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) in 5-HT\n                    <jats:sub>4<\/jats:sub>\n                    -TG atrial preparations. The inotropic and chronotropic effects of LSD were antagonized by 10\u00a0\u00b5M tropisetron in 5-HT\n                    <jats:sub>4<\/jats:sub>\n                    -TG. In contrast, LSD (10\u00a0\u00b5M) increased force of contraction and beating rate in left or right atrial preparations, from H\n                    <jats:sub>2<\/jats:sub>\n                    -TG. After pre-stimulation with cilostamide (1\u00a0\u00b5M), LSD (10\u00a0\u00b5M) increased force of contraction in human atrial preparations (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). The contractile effects of LSD in human atrial preparations could be antagonized by 10\u00a0\u00b5M cimetidine and 1\u00a0\u00b5M GR 125487. LSD leads to H\n                    <jats:sub>2<\/jats:sub>\n                    -histamine receptor and 5-HT\n                    <jats:sub>4<\/jats:sub>\n                    -receptor mediated cardiac effects in humans.\n                  <\/jats:p>","DOI":"10.1007\/s00210-023-02591-6","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T09:05:00Z","timestamp":1688979900000},"page":"221-236","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Lysergic acid diethylamide stimulates cardiac human H2 histamine and cardiac human 5-HT4-serotonin receptors"],"prefix":"10.1007","volume":"397","author":[{"given":"Ulrich","family":"Gergs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Braekow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britt","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Pockes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J.","family":"Humphrys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Kirchhefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Fehse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,4]]},"reference":[{"issue":"4","key":"2591_CR1","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1007\/s00210-022-02348-7","volume":"396","author":"LMR Abella","year":"2023","unstructured":"Abella LMR, Hoffmann R, Neumann J, Hofmann B, Gergs U (2023) Levosimendan increases the phosphorylation state of phospholamban in the isolated human atrium. 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