{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T17:02:16Z","timestamp":1773939736203,"version":"3.50.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1007\/s00210-023-02596-1","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T06:02:01Z","timestamp":1689141721000},"page":"305-315","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Design, synthesis, and biological studies of the new cysteine-N-arylacetamide derivatives as a potent urease inhibitor"],"prefix":"10.1007","volume":"397","author":[{"given":"Mohammad Nazari","family":"Montazer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Asadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Moradkhani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zinat Bahrampour","family":"Omrany","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Mahdavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massoud","family":"Amanlou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,7,12]]},"reference":[{"key":"2596_CR1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1055\/a-0654-5074","volume":"69","author":"MA Abbasi","year":"2019","unstructured":"Abbasi MA, Raza H, ur Rehman A, Siddiqui SZ, Nazir M, Mumtaz A, Shah SA, Seo SY, Hassan M (2019) Synthesis, antioxidant and in-silico studies of potent urease inhibitors: N-(4-{[(4-methoxyphenethyl)-(substituted) amino] sulfonyl} phenyl) acetamides. Drug Res 69:111\u2013120","journal-title":"Drug Res"},{"key":"2596_CR2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-1706-4","volume-title":"Nitrogen economy in tropical soils","author":"N Ahmad","year":"1996","unstructured":"Ahmad N (1996) Nitrogen economy in tropical soils. Kluwer Academic Publishers, Dordrech, The Netherlands"},{"key":"2596_CR3","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1128\/CMR.00006-06","volume":"19","author":"HMS Algood","year":"2006","unstructured":"Algood HMS, Cover TL (2006) Helicobacter pylori persistence: an overview of interactions between H. pylori and host immune defenses. Clin Microbiol Rev 19:597\u2013613","journal-title":"Clin Microbiol Rev"},{"key":"2596_CR4","doi-asserted-by":"publisher","first-page":"6737","DOI":"10.1016\/j.bmc.2006.05.078","volume":"14","author":"Z Amtul","year":"2006","unstructured":"Amtul Z, Kausar N, Follmer C, Rozmahel RF, Kazmi SA, Shekhani MS, Eriksen JL, Khan KM, Choudhary MI (2006) Cysteine based novel noncompetitive inhibitors of urease (s)\u2014distinctive inhibition susceptibility of microbial and plant ureases. Bioorg Med Chem 14:6737\u20136744","journal-title":"Bioorg Med Chem"},{"key":"2596_CR5","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.2174\/0929867023369853","volume":"9","author":"Z Amtul","year":"2002","unstructured":"Amtul Z, Siddiqui RA, Choudhary MI (2002) Chemistry and mechanism of urease inhibition. Curr Med Chem 9:1323\u20131348","journal-title":"Curr Med Chem"},{"key":"2596_CR6","doi-asserted-by":"publisher","first-page":"105592","DOI":"10.1016\/j.bioorg.2021.105592","volume":"120","author":"M Asadi","year":"2022","unstructured":"Asadi M, Iraji A, Sherafati M, Montazer MN, Ansari S, Khanaposhtani MM, Tanideh N, Dianatpour M, Biglar M, Larijani B, Foroumadi A (2022) Synthesis and in vitro urease inhibitory activity of 5-nitrofuran-2-yl-thiadiazole linked to different cyclohexyl-2-(phenylamino) acetamides, in silico and kinetic studies. Bioorg Chem 120:105592","journal-title":"Bioorg Chem"},{"key":"2596_CR7","doi-asserted-by":"publisher","first-page":"2000023","DOI":"10.1002\/ardp.202000023","volume":"353","author":"MS Asgari","year":"2020","unstructured":"Asgari MS, Azizian H, Nazari Montazer M, Mohammadi-Khanaposhtani M, Asadi M, Sepehri S, Ranjbar PR, Rahimi R, Biglar M, Larijani B, Amanlou M (2020) New 1, 2, 3-triazole\u2013(thio) barbituric acid hybrids as urease inhibitors: design, synthesis, in vitro urease inhibition, docking study, and molecular dynamic simulation. Arch Pharm 353:2000023","journal-title":"Arch Pharm"},{"key":"2596_CR8","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.jmb.2010.05.009","volume":"400","author":"A Balasubramanian","year":"2010","unstructured":"Balasubramanian A, Ponnuraj K (2010) Crystal structure of the first plant urease from jack bean: 83 years of journey from its first crystal to molecular structure. J Mol Biol 400:274\u2013283","journal-title":"J Mol Biol"},{"key":"2596_CR9","doi-asserted-by":"crossref","unstructured":"Begum A, Choudhary MI, Betzel C (2012) The first jack bean urease (Canavalia ensiformis) complex obtained at 1.52 resolution","DOI":"10.2210\/pdb4h9m\/pdb"},{"key":"2596_CR10","doi-asserted-by":"crossref","unstructured":"Bell JA, Cao Y, Gunn JR, Day T, Gallicchio E, Zhou Z, Levy R, Farid R (2012) PrimeX and the Schr\u00f6dinger computational chemistry suite of programs","DOI":"10.1107\/97809553602060000864"},{"key":"2596_CR11","volume-title":"Pre-ADMET program","author":"Bioinformatics and Molecular Design Research Center","year":"2014","unstructured":"Bioinformatics and Molecular Design Research Center (2014) Pre-ADMET program. Bioinformatics and Molecular Design Research Center, Seoul, South Korea http:\/\/preadmet.bmdrc.org"},{"key":"2596_CR12","doi-asserted-by":"crossref","unstructured":"Bowers KJ, Chow DE, Xu H, Dror RO, Eastwood MP, Gregersen BA, Klepeis JL, Kolossvary I, Moraes MA, Sacerdoti FD, Salmon JK (2006) Scalable algorithms for molecular dynamics simulations on commodity clusters. InSC\u201906: Proceedings of the 2006 ACM\/IEEE Conference on Supercomputing. IEEE 43-43","DOI":"10.1145\/1188455.1188544"},{"key":"2596_CR13","doi-asserted-by":"publisher","first-page":"575","DOI":"10.3390\/molecules23030575","volume":"23","author":"N Clemente Plaza","year":"2018","unstructured":"Clemente Plaza N, Reig Garc\u00eda-Galbis M, Mart\u00ednez-Espinosa RM (2018) Effects of the usage of l-cysteine (l-Cys) on human health. Molecules 23:575","journal-title":"Molecules"},{"key":"2596_CR14","doi-asserted-by":"publisher","first-page":"99","DOI":"10.4103\/1735-5362.329930","volume":"17","author":"MC Egbujor","year":"2022","unstructured":"Egbujor MC, Okoro UC, Okafor SN, Egu SA, Amasiatu IS, Egwuatu PI, Umeh OR, Ibo EM (2022) Design, synthesis, and molecular docking of cysteine-based sulphonamide derivatives as antimicrobial agents. Res Pharm Sci 17:99","journal-title":"Res Pharm Sci"},{"key":"2596_CR15","doi-asserted-by":"publisher","first-page":"3160","DOI":"10.1016\/j.bmc.2005.12.032","volume":"14","author":"R Farid","year":"2006","unstructured":"Farid R, Day T, Friesner RA, Pearlstein RA (2006) New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies. Bioorg Med Chem 14:3160\u20133173","journal-title":"Bioorg Med Chem"},{"issue":"6","key":"2596_CR16","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/88563","volume":"8","author":"NC Ha","year":"2001","unstructured":"Ha NC, Oh ST, Sung JY, Cha KA, Lee MH, Oh BH (2001) Supramolecular assembly and acid resistance of Helicobacter pylori urease. Nat Struct Mol Biol Jun 8(6):505\u2013509","journal-title":"Nat Struct Mol Biol Jun"},{"issue":"2","key":"2596_CR17","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1021\/ci800324m","volume":"49","author":"TA Halgren","year":"2009","unstructured":"Halgren TA (2009) Identifying and characterizing binding sites and assessing druggability. J Chem Inf Model 49(2):377\u2013389","journal-title":"J Chem Inf Model"},{"key":"2596_CR18","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1080\/13543776.2019.1584612","volume":"29","author":"A Hameed","year":"2019","unstructured":"Hameed A, Al-Rashida M, Uroos M, Qazi SU, Naz S, Ishtiaq M, Khan KM (2019) A patent update on therapeutic applications of urease inhibitors (2012-2018). Expert Opin Ther Pat 29:181\u2013189","journal-title":"Expert Opin Ther Pat"},{"key":"2596_CR19","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1126\/science.7754395","volume":"268","author":"E Jabri","year":"1995","unstructured":"Jabri E, Carr MB, Hausinger RP, Karplus PA (1995) The crystal structure of urease from Klebsiella aerogenes. Sci 268:998\u20131004","journal-title":"Sci"},{"key":"2596_CR20","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.jare.2018.01.007","volume":"13","author":"P Kafarski","year":"2018","unstructured":"Kafarski P, Talma M (2018) Recent advances in design of new urease inhibitors: a review. J Adv Res 13:101\u2013112","journal-title":"J Adv Res"},{"key":"2596_CR21","doi-asserted-by":"publisher","first-page":"e202100618","DOI":"10.1002\/cmdc.202100618","volume":"17","author":"ML Liu","year":"2022","unstructured":"Liu ML, Li WY, Fang HL, Ye YX, Li SY, Song WQ, Xiao ZP, Ouyang H, Zhu HL (2022) Synthesis and biological evaluation of dithiobisacetamides as novel urease inhibitors. Chem Med Chem 17:e202100618","journal-title":"Chem Med Chem"},{"key":"2596_CR22","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1128\/mr.53.1.85-108.1989","volume":"53","author":"HL Mobley","year":"1989","unstructured":"Mobley HL, Hausinger RP (1989) Microbial ureases: significance, regulation, and molecular characterization. Microbiol Rev 53:85\u2013108","journal-title":"Microbiol Rev"},{"key":"2596_CR23","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1128\/mr.59.3.451-480.1995","volume":"59","author":"HL Mobley","year":"1995","unstructured":"Mobley HL, Island MD, Hausinger RP (1995) Molecular biology of microbial ureases. Microbiol Rev 59:451\u2013480","journal-title":"Microbiol Rev"},{"key":"2596_CR24","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/s00044-020-02683-5","volume":"30","author":"M Nazari Montazer","year":"2021","unstructured":"Nazari Montazer M, Asadi M, Bahadorikhalili S, Hosseini FS, Amanlou A, Biglar M, Amanlou M (2021) Design, synthesis, docking study and urease inhibitory activity evaluation of novel 2-((5-amino-1, 3, 4-thiadiazol-2-yl) thio)-N-arylacetamide derivatives. Med Chem Res 30:729\u2013742","journal-title":"Med Chem Res"},{"key":"2596_CR25","doi-asserted-by":"publisher","first-page":"958","DOI":"10.3390\/pr10050958","volume":"10","author":"CC Novoa","year":"2022","unstructured":"Novoa CC, Tortella G, Seabra AB, Diez MC, Rubilar O (2022) Cotton textile with antimicrobial activity and enhanced durability produced by L-cysteine-capped silver nanoparticles. Processes 10:958. https:\/\/doi.org\/10.3390\/pr10050958","journal-title":"Processes"},{"key":"2596_CR26","doi-asserted-by":"publisher","first-page":"239","DOI":"10.4141\/S00-052","volume":"81","author":"CDL Rawluk","year":"2001","unstructured":"Rawluk CDL, Grant CA, Racz GJ (2001) Ammonia volatilization from soils fertilized with urea and varying rates of urease inhibitor NBPT. Can J Soil Sci 81:239\u2013246","journal-title":"Can J Soil Sci"},{"key":"2596_CR27","doi-asserted-by":"publisher","first-page":"e1004062","DOI":"10.1371\/journal.ppat.1004062","volume":"10","author":"JC Rutherford","year":"2014","unstructured":"Rutherford JC (2014) The emerging role of urease as a general microbial virulence factor. PLoS Pathog 10:e1004062.\u00a0https:\/\/doi.org\/10.1371\/journal.ppat.1004062","journal-title":"PLoS Pathog"},{"key":"2596_CR28","doi-asserted-by":"publisher","first-page":"133078","DOI":"10.1016\/j.molstruc.2022.133078","volume":"1263","author":"SE Sadat-Ebrahimi","year":"2022","unstructured":"Sadat-Ebrahimi SE, Bigdelou A, Sooreshjani RH, Montazer MN, Zomorodian K, Irajie C, Yahya-Meymandi A, Biglar M, Larijani B, Amanlou M, Iraji A (2022) Novel phenylurea-pyridinium derivatives as potent urease inhibitors: synthesis, in vitro, and in silico studies. J Mol Struct 1263:133078","journal-title":"J Mol Struct"},{"key":"2596_CR29","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s10822-013-9644-8","volume":"27","author":"GM Sastry","year":"2013","unstructured":"Sastry GM, Adzhigirey M, Day T, Annabhimoju R, Sherman W (2013) Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments. J Comput Aided Mol Des 27:221\u2013234","journal-title":"J Comput Aided Mol Des"},{"key":"2596_CR30","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/S0016-5085(98)70633-X","volume":"114","author":"DR Scott","year":"1998","unstructured":"Scott DR, Weeks D, Hong C, Postius S, Melchers K, Sachs G (1998) The role of internal urease in acid resistance of Helicobacter pylori. Gastroenterology 114:58\u201370","journal-title":"Gastroenterology"},{"key":"2596_CR31","first-page":"28","volume":"7","author":"H Shahbazi-Alavi","year":"2022","unstructured":"Shahbazi-Alavi H, Safaei-Ghomi J (2022) Sonosynthesis of pyrimidines as antimicrobial agents using nano-Fe3O4\u2013L-cysteine. Nano Res 7:28\u201335","journal-title":"Nano Res"},{"key":"2596_CR32","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s10822-007-9133-z","volume":"21","author":"JC Shelley","year":"2007","unstructured":"Shelley JC, Cholleti A, Frye LL, Greenwood JR, Timlin MR, Uchimaya M (2007) Epik: a software program for pK(a ) prediction and protonation state generation for drug-like molecules. J Comput Aided Mol Des 21:681\u2013691","journal-title":"J Comput Aided Mol Des"},{"key":"2596_CR33","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.bioorg.2008.02.001","volume":"36","author":"M Smietana","year":"2008","unstructured":"Smietana M, Clayette P, Mialocq P, Vasseur JJ, Oiry J (2008) Synthesis of new N-isobutyryl-L-cysteine\/MEA conjugates: evaluation of their free radical-scavenging activities and anti-HIV properties in human macrophages. Bioorg Chem 36:133\u2013140","journal-title":"Bioorg Chem"},{"key":"2596_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-022-05736-4","volume":"12","author":"M Sohrabi","year":"2022","unstructured":"Sohrabi M, Nazari Montazer M, Farid SM, Tanideh N, Dianatpour M, Moazzam A, Zomorodian K, Yazdanpanah S, Asadi M, Hosseini S, Biglar M (2022) Design and synthesis of novel nitrothiazolacetamide conjugated to different thioquinazolinone derivatives as anti-urease agents. Sci Rep 12:1\u20134","journal-title":"Sci Rep"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-023-02596-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-023-02596-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-023-02596-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T06:06:08Z","timestamp":1704521168000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-023-02596-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,12]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["2596"],"URL":"https:\/\/doi.org\/10.1007\/s00210-023-02596-1","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-2046031\/v1","asserted-by":"object"}]},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,12]]},"assertion":[{"value":"8 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}