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From the gum resin of\n                    <jats:italic>Boswellia serrata<\/jats:italic>\n                    and\n                    <jats:italic>Boswellia carteri<\/jats:italic>\n                    , the pentacyclic triterpene molecules known as boswellic acid (BA) are extracted. We aimed to provide a detailed overview of the origins, chemistry, synthetic derivatives, pharmacokinetic, and biological activity of numerous\n                    <jats:italic>Boswellia<\/jats:italic>\n                    species and their derivatives. The literature searched for reports of\n                    <jats:italic>B. serrata<\/jats:italic>\n                    and isolated BAs having anti-cancer, anti-microbial, anti-inflammatory, anti-arthritic, hypolipidemic, immunomodulatory, anti-diabetic, hepatoprotective, anti-asthmatic, and clastogenic activities. Our results revealed that the cytotoxic and anticancer effects of\n                    <jats:italic>B. serrata<\/jats:italic>\n                    refer to its triterpenoid component, including BAs. Three-O-acetyl-11-keto\u2014BA was the most promising cytotoxic molecule among tested substances. Activation of caspases, upregulation of Bax expression, downregulation of nuclear factor-kappa B (NF-kB), and stimulation of poly (ADP)-ribose polymerase (PARP) cleavage are the primary mechanisms responsible for cytotoxic and antitumor effects. Evidence suggests that BAs have shown promise in combating a wide range of debilitating disease conditions, including cancer, hepatic, inflammatory, and neurological disorders.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s00210-023-02725-w","type":"journal-article","created":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T11:02:33Z","timestamp":1695466953000},"page":"1477-1504","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["The journey of boswellic acids from synthesis to pharmacological activities"],"prefix":"10.1007","volume":"397","author":[{"given":"Ehab A.","family":"Ragab","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed F.","family":"Abd El-Wahab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0136-7096","authenticated-orcid":false,"given":"Ahmed S.","family":"Doghish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania M.","family":"Salama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nermin","family":"Eissa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4238-7069","authenticated-orcid":false,"given":"Samar F.","family":"Darwish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,23]]},"reference":[{"key":"2725_CR1","unstructured":"Abdallah E (2009) Antibacterial activity and toxicological studies on the oleo-gum resins of Commiphora molmol and Boswellia papyrifera. 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