{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:50:06Z","timestamp":1792018206442,"version":"4.4.0"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004242","name":"Princess Nourah Bint Abdulrahman University","doi-asserted-by":"publisher","award":["PNURSP2023R381"],"award-info":[{"award-number":["PNURSP2023R381"]}],"id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1007\/s00210-023-02754-5","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T11:03:27Z","timestamp":1697022207000},"page":"2335-2345","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cadmium-induced lung injury is associated with oxidative stress, apoptosis, and altered SIRT1 and Nrf2\/HO-1 signaling; protective role of the melatonin agonist agomelatine"],"prefix":"10.1007","volume":"397","author":[{"given":"Reem S.","family":"Alruhaimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad H. M.","family":"Hassanein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May N.","family":"Bin-Jumah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0279-6500","authenticated-orcid":false,"given":"Ayman M.","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,11]]},"reference":[{"key":"2754_CR1","first-page":"838","volume":"13","author":"NG Abraham","year":"1985","unstructured":"Abraham NG, Lutton JD, Levere RD (1985) Heme metabolism and erythropoiesis in abnormal iron states: role of \u03b4-aminolevulinic acid synthase and heme oxygenase. Exp Hematol 13:838\u2013843","journal-title":"Exp Hematol"},{"key":"2754_CR2","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s10571-013-9949-0","volume":"33","author":"CC Aguiar","year":"2013","unstructured":"Aguiar CC, Almeida AB, Ara\u00fajo PV, Vasconcelos GS, Chaves EM, do Vale OC, Mac\u00eado DS, Leal LK, de Barros Viana GS, Vasconcelos SM (2013) Effects of agomelatine on oxidative stress in the brain of mice after chemically induced seizures. Cell Mol Neurobiol 33:825\u2013835","journal-title":"Cell Mol Neurobiol"},{"key":"2754_CR3","doi-asserted-by":"crossref","unstructured":"Alam SI, Kim MW, Shah FA, Saeed K, Ullah R, Kim MO (2021) Alpha-linolenic acid impedes cadmium-induced oxidative stress, neuroinflammation, and neurodegeneration in mouse brain. Cells 10:2274","DOI":"10.3390\/cells10092274"},{"key":"2754_CR4","doi-asserted-by":"crossref","unstructured":"Alruhaimi RS, Hassanein EHM, Abd El-Aziz MK, Siddiq Abduh M, Bin-Ammar A, Kamel EM, Mahmoud AM (2023) The melatonin receptor agonist agomelatine protects against acute pancreatitis induced by cadmium by attenuating inflammation and oxidative stress and modulating Nrf2\/HO-1 pathway. Int Immunopharmacol 124:110833","DOI":"10.1016\/j.intimp.2023.110833"},{"key":"2754_CR5","unstructured":"Ashizawa A, Faroon O, Ingerman L, Jenkins K, Tucker P, Wright S (2012) Toxicological profile for cadmium. U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Atlanta"},{"key":"2754_CR6","volume":"311","author":"AG Bakr","year":"2022","unstructured":"Bakr AG, Hassanein EHM, Ali FEM, El-Shoura EAM (2022) Combined apocynin and carvedilol protect against cadmium-induced testicular damage via modulation of inflammatory response and redox-sensitive pathways. Life Sci 311:121152","journal-title":"Life Sci"},{"key":"2754_CR7","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","volume":"87","author":"K Bedard","year":"2007","unstructured":"Bedard K, Krause KH (2007) The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 87:245\u2013313","journal-title":"Physiol Rev"},{"key":"2754_CR8","first-page":"557","volume":"128","author":"A Bernard","year":"2008","unstructured":"Bernard A (2008) Cadmium & its adverse effects on human health. Indian J Med Res 128:557\u2013564","journal-title":"Indian J Med Res"},{"key":"2754_CR9","doi-asserted-by":"crossref","first-page":"R44","DOI":"10.1186\/bcr2599","volume":"12","author":"C Cadenas","year":"2010","unstructured":"Cadenas C, Franckenstein D, Schmidt M, Gehrmann M, Hermes M, Geppert B, Schormann W, Maccoux LJ, Schug M, Schumann A, Wilhelm C, Freis E, Ickstadt K, Rahnenf\u00fchrer J, Baumbach JI, Sickmann A, Hengstler JG (2010) Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer. Breast Cancer Res 12:R44","journal-title":"Breast Cancer Res"},{"key":"2754_CR10","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s11011-020-00634-y","volume":"36","author":"FN Cankara","year":"2021","unstructured":"Cankara FN, G\u00fcnayd\u0131n C, \u00c7elik ZB, \u015eahin Y, Pekg\u00f6z \u015e, Erzurumlu Y, G\u00fclle K (2021) Agomelatine confers neuroprotection against cisplatin-induced hippocampal neurotoxicity. Metab Brain Dis 36:339\u2013349","journal-title":"Metab Brain Dis"},{"key":"2754_CR11","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/abbi.1997.0197","volume":"346","author":"E Casalino","year":"1997","unstructured":"Casalino E, Sblano C, Landriscina C (1997) Enzyme activity alteration by cadmium administration to rats: the possibility of iron involvement in lipid peroxidation. Arch Biochem Biophys 346:171\u2013179","journal-title":"Arch Biochem Biophys"},{"key":"2754_CR12","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s10534-010-9329-x","volume":"23","author":"A Cuypers","year":"2010","unstructured":"Cuypers A, Plusquin M, Remans T, Jozefczak M, Keunen E, Gielen H, Opdenakker K, Nair AR, Munters E, Artois TJ (2010) Cadmium stress: an oxidative challenge. Biometals 23:927\u2013940","journal-title":"Biometals"},{"key":"2754_CR13","doi-asserted-by":"crossref","first-page":"10981","DOI":"10.1007\/s11356-019-07455-2","volume":"27","author":"EC de Lima","year":"2020","unstructured":"de Lima EC, de Moura CFG, Silva MJD, Vilegas W, Santamarina AB, Pisani LP, de Oliveira F, Ribeiro DA (2020) Therapeutical properties of Mimosa caesalpiniifolia in rat liver intoxicated with cadmium. Environ Sci Pollut Res Int 27:10981\u201310989","journal-title":"Environ Sci Pollut Res Int"},{"key":"2754_CR14","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1365-2613.2009.00692.x","volume":"91","author":"PF de Souza","year":"2010","unstructured":"de Souza PF, Diamante MA, Dolder H (2010) Testis response to low doses of cadmium in Wistar rats. Int J Exp Pathol 91:125\u2013131","journal-title":"Int J Exp Pathol"},{"key":"2754_CR15","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","volume":"82","author":"GL Ellman","year":"1959","unstructured":"Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82:70\u201377","journal-title":"Arch Biochem Biophys"},{"key":"2754_CR16","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1007\/s43440-019-00049-2","volume":"72","author":"E Eraslan","year":"2020","unstructured":"Eraslan E, Tanyeli A, G\u00fcler MC, Kurt N, Yetim Z (2020) Agomelatine prevents indomethacin-induced gastric ulcer in rats. Pharmacol Rep 72:984\u2013991","journal-title":"Pharmacol Rep"},{"key":"2754_CR17","doi-asserted-by":"crossref","unstructured":"Fasano C, Disciglio V, Bertora S, Lepore Signorile M, Simone C (2019) FOXO3a from the nucleus to the mitochondria: a round trip in cellular stress response. Cells 8:1110","DOI":"10.3390\/cells8091110"},{"key":"2754_CR18","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.3390\/ijerph110101049","volume":"11","author":"K Fulcher","year":"2014","unstructured":"Fulcher K, Gibb H (2014) Setting the research agenda on the health effects of chemicals. Int J Environ Res Public Health 11:1049\u20131057","journal-title":"Int J Environ Res Public Health"},{"key":"2754_CR19","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1128\/MCB.25.1.162-171.2005","volume":"25","author":"M Furukawa","year":"2005","unstructured":"Furukawa M, Xiong Y (2005) BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. Mol Cell Biol 25:162\u2013171","journal-title":"Mol Cell Biol"},{"key":"2754_CR20","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12514","volume":"65","author":"A Galano","year":"2018","unstructured":"Galano A, Reiter RJ (2018) Melatonin and its metabolites vs oxidative stress: from individual actions to collective protection. J Pineal Res 65:e12514","journal-title":"J Pineal Res"},{"key":"2754_CR21","doi-asserted-by":"crossref","first-page":"7410","DOI":"10.1038\/sj.onc.1209086","volume":"24","author":"EL Greer","year":"2005","unstructured":"Greer EL, Brunet A (2005) FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 24:7410\u20137425","journal-title":"Oncogene"},{"key":"2754_CR22","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1101\/gad.227439.113","volume":"27","author":"L Guarente","year":"2013","unstructured":"Guarente L (2013) Calorie restriction and sirtuins revisited. Genes Dev 27:2072\u20132085","journal-title":"Genes Dev"},{"key":"2754_CR23","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1101\/gad.1467506","volume":"20","author":"MC Haigis","year":"2006","unstructured":"Haigis MC, Guarente LP (2006) Mammalian sirtuins\u2014emerging roles in physiology, aging, and calorie restriction. Genes Dev 20:2913\u20132921","journal-title":"Genes Dev"},{"key":"2754_CR24","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1055\/a-1221-4733","volume":"70","author":"BA Handan","year":"2020","unstructured":"Handan BA, De Moura CFG, Cardoso CM, Santamarina AB, Pisani LP, Ribeiro DA (2020) Protective effect of grape and apple juices against cadmium intoxication in the kidney of rats. Drug Research 70:503\u2013511","journal-title":"Drug Research"},{"key":"2754_CR25","first-page":"1675957","volume":"2020","author":"EHM Hassanein","year":"2020","unstructured":"Hassanein EHM, Sayed AM, Hussein OE, Mahmoud AM (2020) Coumarins as modulators of the Keap1\/Nrf2\/ARE signaling pathway. Oxid Med Cell Longev 2020:1675957","journal-title":"Oxid Med Cell Longev"},{"key":"2754_CR26","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1016\/j.biopha.2018.11.093","volume":"109","author":"WG Hozayen","year":"2019","unstructured":"Hozayen WG, Mahmoud AM, Desouky EM, El-Nahass E-S, Soliman HA, Farghali AA (2019) Cardiac and pulmonary toxicity of mesoporous silica nanoparticles is associated with excessive ROS production and redox imbalance in Wistar rats. Biomed Pharmacother 109:2527\u20132538","journal-title":"Biomed Pharmacother"},{"key":"2754_CR27","first-page":"87","volume":"14","author":"CO Ikediobi","year":"2004","unstructured":"Ikediobi CO, Badisa VL, Ayuk-Takem LT, Latinwo LM, West J (2004) Response of antioxidant enzymes and redox metabolites to cadmium-induced oxidative stress in CRL-1439 normal rat liver cells. Int J Mol Med 14:87\u201392","journal-title":"Int J Mol Med"},{"key":"2754_CR28","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/08923973.2021.1999973","volume":"44","author":"MY Kamel","year":"2022","unstructured":"Kamel MY, Ahmed SM, Abdelzaher WY, Welson NN, Abdel-Aziz AM (2022) Role of IL-6\/STAT3 pathway in mediating the protective effect of agomelatine against methotrexate-induced lung\/intestinal tissues damage in rats. Immunopharmacol Immunotoxicol 44:35\u201346","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"2754_CR29","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101541","volume":"33","author":"K Kato","year":"2020","unstructured":"Kato K, Hecker L (2020) NADPH oxidases: Pathophysiology and therapeutic potential in age-associated pulmonary fibrosis. Redox Biol 33:101541","journal-title":"Redox Biol"},{"key":"2754_CR30","doi-asserted-by":"crossref","first-page":"6183","DOI":"10.1016\/S0021-9258(20)81842-0","volume":"251","author":"JH Keen","year":"1976","unstructured":"Keen JH, Habig WH, Jakoby WB (1976) Mechanism for the several activities of the glutathione S-transferases. J Biol Chem 251:6183\u20136188","journal-title":"J Biol Chem"},{"key":"2754_CR31","doi-asserted-by":"crossref","first-page":"127","DOI":"10.5152\/eurasianjmed.2021.20342","volume":"53","author":"D K\u00f6se","year":"2021","unstructured":"K\u00f6se D, Y\u00fcksel TN, Hal\u0131c\u0131 Z, \u00c7ad\u0131rc\u0131 E, G\u00fcrb\u00fcz MA (2021) The effects of agomelatine treatment on lipopolysaccharide-induced septic lung injuries in rats. Eurasian J Med 53:127\u2013131","journal-title":"Eurasian J Med"},{"key":"2754_CR32","doi-asserted-by":"crossref","first-page":"15754","DOI":"10.1074\/jbc.RA120.013632","volume":"295","author":"JL Larson-Casey","year":"2020","unstructured":"Larson-Casey JL, Gu L, Fiehn O, Carter AB (2020) Cadmium-mediated lung injury is exacerbated by the persistence of classically activated macrophages. J Biol Chem 295:15754\u201315766","journal-title":"J Biol Chem"},{"key":"2754_CR33","doi-asserted-by":"crossref","unstructured":"Lawrence RA, Burk RFJB, communications br (1976) Glutathione peroxidase activity in selenium-deficient rat liver. 71: 952-958","DOI":"10.1016\/0006-291X(76)90747-6"},{"key":"2754_CR34","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.bcp.2012.05.005","volume":"84","author":"IT Lee","year":"2012","unstructured":"Lee IT, Yang CM (2012) Role of NADPH oxidase\/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases. Biochem Pharmacol 84:581\u2013590","journal-title":"Biochem Pharmacol"},{"key":"2754_CR35","doi-asserted-by":"crossref","unstructured":"Li L, Zhang S, Xin Y, Sun J, Xie F, Yang L, Chen Z, Chen H, Liu F, Xuan YJSR (2018) Role of Quzhou Fructus Aurantii extract in preventing and treating acute lung injury and inflammation. 8: 1-11","DOI":"10.1038\/s41598-018-20083-z"},{"key":"2754_CR36","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) Method. Methods (san Diego, Calif) 25:402\u2013408","journal-title":"Methods (san Diego, Calif)"},{"key":"2754_CR37","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1016\/j.bbagen.2012.09.008","volume":"1830","author":"SC Lu","year":"2013","unstructured":"Lu SC (2013) Glutathione synthesis. Biochim Biophys Acta 1830:3143\u20133153","journal-title":"Biochim Biophys Acta"},{"key":"2754_CR38","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13024-017-0150-7","volume":"12","author":"MW Ma","year":"2017","unstructured":"Ma MW, Wang J, Zhang Q, Wang R, Dhandapani KM, Vadlamudi RK, Brann DW (2017) NADPH oxidase in brain injury and neurodegenerative disorders. Mol Neurodegener 12:7","journal-title":"Mol Neurodegener"},{"key":"2754_CR39","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1055\/a-1647-2418","volume":"72","author":"MA Mahlooji","year":"2022","unstructured":"Mahlooji MA, Heshmati A, Kheiripour N, Ghasemi H, Asl SS, Solgi G, Ranjbar A, Hosseini A (2022) Evaluation of protective effects of curcumin and nanocurcumin on aluminium phosphide-induced subacute lung injury in rats: modulation of oxidative stress through SIRT1\/FOXO3 signalling pathway. Drug Res (stuttg) 72:100\u2013108","journal-title":"Drug Res (stuttg)"},{"key":"2754_CR40","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119600","volume":"278","author":"AM Mahmoud","year":"2021","unstructured":"Mahmoud AM, Abd El-Ghafar OAM, Alzoghaibi MA, Hassanein EHM (2021) Agomelatine prevents gentamicin nephrotoxicity by attenuating oxidative stress and TLR-4 signaling, and upregulating PPAR\u03b3 and SIRT1. Life Sci 278:119600","journal-title":"Life Sci"},{"key":"2754_CR41","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","volume":"47","author":"S Marklund","year":"1974","unstructured":"Marklund S, Marklund G (1974) Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47:469\u2013474","journal-title":"Eur J Biochem"},{"key":"2754_CR42","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0003-2697(78)90342-1","volume":"86","author":"M Mihara","year":"1978","unstructured":"Mihara M, Uchiyama M (1978) Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 86:271\u2013278","journal-title":"Anal Biochem"},{"key":"2754_CR43","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1006\/enrs.2002.4396","volume":"90","author":"WI Mortada","year":"2002","unstructured":"Mortada WI, Sobh MA, El-Defrawy MM, Farahat SE (2002) Reference intervals of cadmium, lead, and mercury in blood, urine, hair, and nails among residents in Mansoura City, Nile Delta. Egypt Environ Res 90:104\u2013110","journal-title":"Egypt Environ Res"},{"key":"2754_CR44","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1089\/ars.2012.4713","volume":"19","author":"Y Olmos","year":"2013","unstructured":"Olmos Y, Sanchez-Gomez FJ, Wild B, Garcia-Quintans N, Cabezudo S, Lamas S, Monsalve M (2013) SirT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a\/PGC-1alpha complex. Antioxid Redox Signal 19:1507\u20131521","journal-title":"Antioxid Redox Signal"},{"key":"2754_CR45","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1039\/c1mt00066g","volume":"3","author":"RS Pappas","year":"2011","unstructured":"Pappas RS (2011) Toxic elements in tobacco and in cigarette smoke: inflammation and sensitization. Metallomics\u202f: Integr Biometal Sci 3:1181\u20131198","journal-title":"Metallomics : Integr Biometal Sci"},{"key":"2754_CR46","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1517\/13543784.2012.714771","volume":"21","author":"L Paulis","year":"2012","unstructured":"Paulis L, Simko F, Laudon M (2012) Cardiovascular effects of melatonin receptor agonists. Expert Opin Investig Drugs 21:1661\u20131678","journal-title":"Expert Opin Investig Drugs"},{"key":"2754_CR47","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.toxlet.2020.07.027","volume":"333","author":"JEG Pinheiro J\u00fanior","year":"2020","unstructured":"Pinheiro J\u00fanior JEG, Moraes PZ, Rodriguez MD, Sim\u00f5es MR, Cibin F, Pinton S, Barbosa Junior F, Pe\u00e7anha FM, Vassallo DV, Miguel M, Wiggers GA (2020) Cadmium exposure activates NADPH oxidase, renin-angiotensin system and cyclooxygenase 2 pathways in arteries, inducing hypertension and vascular damage. Toxicol Lett 333:80\u201389","journal-title":"Toxicol Lett"},{"key":"2754_CR48","first-page":"135","volume":"8","author":"M Rafati Rahimzadeh","year":"2017","unstructured":"Rafati Rahimzadeh M, Rafati Rahimzadeh M, Kazemi S, Moghadamnia AA (2017) Cadmium toxicity and treatment: an update. Caspian J Intern Med 8:135\u2013145","journal-title":"Caspian J Intern Med"},{"key":"2754_CR49","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1080\/09603123.2013.835032","volume":"24","author":"A Rani","year":"2014","unstructured":"Rani A, Kumar A, Lal A, Pant M (2014) Cellular mechanisms of cadmium-induced toxicity: a review. Int J Environ Health Res 24:378\u2013399","journal-title":"Int J Environ Health Res"},{"key":"2754_CR50","doi-asserted-by":"crossref","unstructured":"Reed JC, Doctor KS, Godzik A (2004) The domains of apoptosis: a genomics perspective. Sci STKE 2004(239):re9","DOI":"10.1126\/stke.2392004re9"},{"key":"2754_CR51","doi-asserted-by":"crossref","unstructured":"Saha S, Sadhukhan P, Sinha K, Agarwal N, Sil PCJB, reports b (2016) Mangiferin attenuates oxidative stress induced renal cell damage through activation of PI3K induced Akt and Nrf-2 mediated signaling pathways. 5: 313-327","DOI":"10.1016\/j.bbrep.2016.01.011"},{"key":"2754_CR52","first-page":"17","volume":"3","author":"A Sarkar","year":"2013","unstructured":"Sarkar A, Ravindran G, Krishnamurthy V (2013) A brief review on the effect of cadmium toxicity: from cellular to organ level. Int J Biotechnol Res 3:17\u201336","journal-title":"Int J Biotechnol Res"},{"key":"2754_CR53","doi-asserted-by":"crossref","first-page":"9237263","DOI":"10.1155\/2017\/9237263","volume":"2017","author":"S Satta","year":"2017","unstructured":"Satta S, Mahmoud AM, Wilkinson FL, Yvonne Alexander M, White SJ (2017) The role of Nrf2 in cardiovascular function and disease. Oxid Med Cell Longev 2017:9237263","journal-title":"Oxid Med Cell Longev"},{"key":"2754_CR54","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.biochem.74.082803.133500","volume":"75","author":"AA Sauve","year":"2006","unstructured":"Sauve AA, Wolberger C, Schramm VL, Boeke JD (2006) The biochemistry of sirtuins. Annu Rev Biochem 75:435\u2013465","journal-title":"Annu Rev Biochem"},{"key":"2754_CR55","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118173","volume":"259","author":"AM Sayed","year":"2020","unstructured":"Sayed AM, Hassanein EHM, Salem SH, Hussein OE, Mahmoud AM (2020) Flavonoids-mediated SIRT1 signaling activation in hepatic disorders. Life Sci 259:118173","journal-title":"Life Sci"},{"key":"2754_CR56","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S0006-291X(03)00871-4","volume":"305","author":"Y Shi","year":"2003","unstructured":"Shi Y, Chen J, Weng C, Chen R, Zheng Y, Chen Q, Tang H (2003) Identification of the protein-protein contact site and interaction mode of human VDAC1 with Bcl-2 family proteins. Biochem Biophys Res Commun 305:989\u2013996","journal-title":"Biochem Biophys Res Commun"},{"key":"2754_CR57","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.cell.2008.11.029","volume":"135","author":"GC Shore","year":"2008","unstructured":"Shore GC, Nguyen M (2008) Bcl-2 proteins and apoptosis: choose your partner. Cell 135:1004\u20131006","journal-title":"Cell"},{"key":"2754_CR58","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1113\/expphysiol.1997.sp004024","volume":"82","author":"H Sies","year":"1997","unstructured":"Sies H (1997) Oxidative stress: oxidants and antioxidants. Exp Physiol 82:291\u2013295","journal-title":"Exp Physiol"},{"key":"2754_CR59","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1089\/ars.2017.7290","volume":"28","author":"CK Singh","year":"2018","unstructured":"Singh CK, Chhabra G, Ndiaye MA, Garcia-Peterson LM, Mack NJ, Ahmad N (2018) The role of sirtuins in antioxidant and redox signaling. Antioxid Redox Signal 28:643\u2013661","journal-title":"Antioxid Redox Signal"},{"issue":"2","key":"2754_CR60","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0008-6363(98)00278-8","volume":"41","author":"RC Siow","year":"1999","unstructured":"Siow RC, Sato H, GE Mann (1999) Heme oxygenase-carbon monoxide signalling pathway in atherosclerosis: anti-atherogenic actions of bilirubin and carbon monoxide? Cardiovasc Res 41(2):385\u201394","journal-title":"Cardiovasc Res"},{"key":"2754_CR61","unstructured":"Suvarna SK, Layton C, Bancroft JD (2013) Bancroft\u2019s theory and practice of histological techniques. Churchill Livingstone Elsevier, [Oxford]"},{"key":"2754_CR62","doi-asserted-by":"crossref","first-page":"8477","DOI":"10.1073\/pnas.1306759110","volume":"110","author":"ND Thomsen","year":"2013","unstructured":"Thomsen ND, Koerber JT, Wells JA (2013) Structural snapshots reveal distinct mechanisms of procaspase-3 and-7 activation. Proc Natl Acad Sci 110:8477\u20138482","journal-title":"Proc Natl Acad Sci"},{"key":"2754_CR63","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.bbamcr.2011.06.002","volume":"1813","author":"G Tzivion","year":"2011","unstructured":"Tzivion G, Dobson M, Ramakrishnan G (2011) FoxO transcription factors; regulation by AKT and 14-3-3 proteins. Biochem Biophys Acta 1813:1938\u20131945","journal-title":"Biochem Biophys Acta"},{"key":"2754_CR64","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0092-8674(01)00527-X","volume":"107","author":"H Vaziri","year":"2001","unstructured":"Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK, Guarente L, Weinberg RA (2001) hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107:149\u2013159","journal-title":"Cell"},{"key":"2754_CR65","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.biopha.2016.12.102","volume":"87","author":"G Yigitturk","year":"2017","unstructured":"Yigitturk G, Acara AC, Erbas O, Oltulu F, Yavasoglu NUK, Uysal A, Yavasoglu A (2017) The antioxidant role of agomelatine and gallic acid on oxidative stress in STZ induced type I diabetic rat testes. Biomed Pharmacother 87:240\u2013246","journal-title":"Biomed Pharmacother"},{"key":"2754_CR66","first-page":"901","volume":"29","author":"CS Yucetas","year":"2019","unstructured":"Yucetas CS, Ucler N, Cakir T (2019) The effects of agomelatine on the biochemical and pathological features of cisplatin-induced peripheral neuropathy: the first experimental study in rats. Turk Neurosurg 29:901\u2013908","journal-title":"Turk Neurosurg"},{"key":"2754_CR67","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3892\/mmr.2014.2679","volume":"11","author":"F Zhang","year":"2015","unstructured":"Zhang F, Li ZL, Xu XM, Hu Y, Yao JH, Xu W, Jing HR, Wang S, Ning SL, Tian XF (2015) Protective effects of icariin-mediated SIRT1\/FOXO3 signaling pathway on intestinal ischemia\/reperfusion-induced acute lung injury. Mol Med Rep 11:269\u2013276","journal-title":"Mol Med Rep"},{"key":"2754_CR68","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/jpi.12322","volume":"60","author":"Y Zhang","year":"2016","unstructured":"Zhang Y, Li X, Grailer JJ, Wang N, Wang M, Yao J, Zhong R, Gao GF, Ward PA, Tan DX, Li X (2016) Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome. J Pineal Res 60:405\u2013414","journal-title":"J Pineal Res"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-023-02754-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-023-02754-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-023-02754-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T21:28:28Z","timestamp":1710278908000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-023-02754-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,11]]},"references-count":68,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["2754"],"URL":"https:\/\/doi.org\/10.1007\/s00210-023-02754-5","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,11]]},"assertion":[{"value":"4 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}