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To automate data acquisition from clincialtrials.gov via its API, data processing, and storage, we created custom software by leveraging a variety of open-source tools. Data were stored in a relational database and annotated facilitating a specially adapted web application. Through the data analysis, we identified use cases for repurposing and reviewed backgrounds and results in the scientific literature. Even though we found very few trials with published results for repurpose indications, extended literature research revealed some prominent use cases: Cetirizine seems promising in mitigating infusion-associated reactions and is also more effective than placebo in the treatment of androgenetic alopecia. Loratadine may be beneficial in the prophylaxis of G-CSF-related bone pain. In COVID-19, H<jats:sub>1<\/jats:sub>R antagonists may be helpful, but placebo-controlled scientific evidence is needed. For asthma, the effect of H<jats:sub>1<\/jats:sub>R antagonists only seems to be secondary by alleviating allergy symptoms. Our novel method to find potential use cases for repurposing of H<jats:sub>1<\/jats:sub>R antagonists allows for high automation, reduces human error, and was successful in revealing potential areas of interest. The software could be used for similar research questions and analyses in the future.<\/jats:p>","DOI":"10.1007\/s00210-023-02796-9","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T09:01:58Z","timestamp":1698051718000},"page":"2995-3018","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Repurposing of H1-receptor antagonists (levo)cetirizine, (des)loratadine, and fexofenadine as a case study for systematic analysis of trials on clinicaltrials.gov using semi-automated processes with custom-coded software"],"prefix":"10.1007","volume":"397","author":[{"given":"Tim","family":"Specht","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Seifert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,23]]},"reference":[{"issue":"Suppl 8","key":"2796_CR1","first-page":"S144","volume":"71","author":"HM Al-Kuraishy","year":"2021","unstructured":"Al-Kuraishy HM, Al-Rubiey HF, Al-Buhadily AK, Al-Gareeb AI (2021) Anti-histamines and Covid-19: hype or hope. 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