{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:37:03Z","timestamp":1778629023904,"version":"3.51.4"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Hangzhou Special Fund for supporting science and technology in the development of biomedical and health industries","award":["2021WJCY143"],"award-info":[{"award-number":["2021WJCY143"]}]},{"name":"Hangzhou Special Fund for supporting science and technology in the development of biomedical and health industries","award":["2021WJCY127"],"award-info":[{"award-number":["2021WJCY127"]}]},{"name":"Project of medical and health technology development program in Shandong province","award":["2019WS366"],"award-info":[{"award-number":["2019WS366"]}]},{"name":"PhD Research Foundation of Affiliated Hospital of Jining Medical University","award":["2017-BS-007"],"award-info":[{"award-number":["2017-BS-007"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1007\/s00210-023-02864-0","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T07:02:08Z","timestamp":1702450928000},"page":"4299-4307","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Study on the mechanism of vitamin E alleviating non-alcoholic fatty liver function based on non-targeted metabolomics analysis in rats"],"prefix":"10.1007","volume":"397","author":[{"given":"Baiyun","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyue","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajuan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoxuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junping","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,12,13]]},"reference":[{"key":"2864_CR1","doi-asserted-by":"publisher","first-page":"656025","DOI":"10.1155\/2012\/656025","volume":"2012","author":"SS Abukhadir","year":"2012","unstructured":"Abukhadir SS, Mohamed N et al (2012) Effects of palm vitamin E on bone-formation-related gene expression in nicotine-treated rats. Evid Based Complement Alternat Med 2012:656025","journal-title":"Evid Based Complement Alternat Med"},{"key":"2864_CR2","doi-asserted-by":"crossref","unstructured":"Adornetto A, Rombola\u00a0L et al (2020) Natural products: evidence for neuroprotection to be exploited in glaucoma. Nutrients 12(10):3158","DOI":"10.3390\/nu12103158"},{"key":"2864_CR3","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/843569","volume":"2012","author":"AO Afolabi","year":"2012","unstructured":"Afolabi AO, Olotu OO et al (2012) Vitamins E and C alleviate the germ cell loss and oxidative stress in cryptorchidism when administered separately but not when combined in rats. ISRN Pharmacol 2012:843569","journal-title":"ISRN Pharmacol"},{"key":"2864_CR4","doi-asserted-by":"crossref","unstructured":"Aladaileh SH, Saghir\u00a0SAM et al (2019) Antihyperlipidemic and antioxidant effects of Averrhoa carambola extract in high-fat diet-fed rats. Biomedicines 7(3):72","DOI":"10.3390\/biomedicines7030072"},{"key":"2864_CR5","doi-asserted-by":"crossref","unstructured":"Barrera G, Gentile F et al (2016) Mitochondrial dysfunction in cancer and neurodegenerative diseases: spotlight on fatty acid oxidation and lipoperoxidation products. Antioxidants (Basel) 5(1):7","DOI":"10.3390\/antiox5010007"},{"key":"2864_CR6","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.jnutbio.2017.06.003","volume":"47","author":"D Bartolini","year":"2017","unstructured":"Bartolini D, Torquato P et al (2017) Nonalcoholic fatty liver disease impairs the cytochrome P-450-dependent metabolism of alpha-tocopherol (vitamin E). J Nutr Biochem 47:120\u2013131","journal-title":"J Nutr Biochem"},{"issue":"4","key":"2864_CR7","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1021\/jf903930k","volume":"58","author":"SJ Bruce","year":"2010","unstructured":"Bruce SJ, Guy PA et al (2010) Quantitative measurement of betaine and free choline in plasma, cereals and cereal products by isotope dilution LC-MS\/MS. J Agric Food Chem 58(4):2055\u20132061","journal-title":"J Agric Food Chem"},{"issue":"12","key":"2864_CR8","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1097\/CM9.0000000000000289","volume":"132","author":"XQ Chen","year":"2019","unstructured":"Chen XQ, Qiu K et al (2019) Application and prospects of butylphthalide for the treatment of neurologic diseases. Chin Med J (engl) 132(12):1467\u20131477","journal-title":"Chin Med J (engl)"},{"key":"2864_CR9","doi-asserted-by":"crossref","unstructured":"Dibba P, Li\u00a0A et al (2018) Mechanistic potential and therapeutic implications of Cannabinoids in nonalcoholic fatty liver disease. Medicines (Basel) 5(2):47","DOI":"10.3390\/medicines5020047"},{"key":"2864_CR10","doi-asserted-by":"crossref","unstructured":"El Okle OS, Tohamy HG et al (2022) Ornipural((R)) mitigates malathion-induced hepato-renal damage in rats via amelioration of oxidative stress biomarkers, restoration of antioxidant activity, and attenuation of inflammatory response. Antioxidants (Basel) 11(4):757","DOI":"10.3390\/antiox11040757"},{"key":"2864_CR11","doi-asserted-by":"publisher","first-page":"747","DOI":"10.3389\/fphar.2017.00747","volume":"8","author":"J Fang","year":"2017","unstructured":"Fang J, Gao L et al (2017) \u201cQuantitative and Systems Pharmacology 3. Network-based identification of new targets for natural products enables potential uses in aging-associated disorders.\u201d Front Pharmacol 8:747","journal-title":"Front Pharmacol"},{"key":"2864_CR12","doi-asserted-by":"publisher","first-page":"825985","DOI":"10.1155\/2013\/825985","volume":"2013","author":"RG Feresin","year":"2013","unstructured":"Feresin RG, Johnson SA et al (2013) Effects of vitamin E on bone biomechanical and histomorphometric parameters in ovariectomized rats. J Osteoporos 2013:825985","journal-title":"J Osteoporos"},{"issue":"4","key":"2864_CR13","first-page":"583","volume":"14","author":"X Gao","year":"2022","unstructured":"Gao X, Wang J et al (2022) Reduning injection prevents carrageenan-induced inflammation in rats by serum and urine metabolomics analysis. Chin Herb Med 14(4):583\u2013591","journal-title":"Chin Herb Med"},{"key":"2864_CR14","doi-asserted-by":"publisher","first-page":"38942","DOI":"10.1038\/srep38942","volume":"6","author":"Y Hao","year":"2016","unstructured":"Hao Y, Huang J et al (2016) Differential protein expression in metallothionein protection from depleted uranium-induced nephrotoxicity. Sci Rep 6:38942","journal-title":"Sci Rep"},{"issue":"7","key":"2864_CR15","first-page":"658","volume":"39","author":"F Jiang","year":"2011","unstructured":"Jiang F, Zhu PL et al (2011) Effects of telmisartan and pyridoxamine on abdominal aorta vascular remodeling in spontaneously hypertensive rats. Zhonghua Xin Xue Guan Bing Za Zhi 39(7):658\u2013663","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"issue":"7","key":"2864_CR16","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/nrm.2016.25","volume":"17","author":"CH Johnson","year":"2016","unstructured":"Johnson CH, Ivanisevic J et al (2016) Metabolomics: beyond biomarkers and towards mechanisms. Nat Rev Mol Cell Biol 17(7):451\u2013459","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"2864_CR17","doi-asserted-by":"publisher","first-page":"73","DOI":"10.3177\/jnsv.59.73","volume":"59","author":"T Kaimoto","year":"2013","unstructured":"Kaimoto T, Shibuya M et al (2013) High incidence of lipid deposition in the liver of rats fed a diet supplemented with branched-chain amino acids under vitamin B6 deficiency. J Nutr Sci Vitaminol (tokyo) 59(1):73\u201378","journal-title":"J Nutr Sci Vitaminol (tokyo)"},{"issue":"12","key":"2864_CR18","volume":"14","author":"J Karedath","year":"2022","unstructured":"Karedath J, Javed H et al (2022) Effect of vitamin E on clinical outcomes in patients with non-alcoholic fatty liver disease: a meta-analysis. Cureus 14(12):e32764","journal-title":"Cureus"},{"issue":"4","key":"2864_CR19","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1007\/s10787-021-00826-7","volume":"29","author":"P Kumar","year":"2021","unstructured":"Kumar P, Kumar M et al (2021) Role of vitamins and minerals as immunity boosters in COVID-19. Inflammopharmacology 29(4):1001\u20131016","journal-title":"Inflammopharmacology"},{"issue":"2","key":"2864_CR20","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1002\/jcsm.12901","volume":"13","author":"CW Li","year":"2022","unstructured":"Li CW, Yu K et al (2022a) Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review. J Cachexia Sarcopenia Muscle 13(2):781\u2013794","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"1","key":"2864_CR21","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.1186\/s12889-022-14922-y","volume":"22","author":"H Li","year":"2022","unstructured":"Li H, Ge M et al (2022b) Associations of environmental factors with total cholesterol level of middle-aged and elderly people in China. BMC Public Health 22(1):2423","journal-title":"BMC Public Health"},{"key":"2864_CR22","doi-asserted-by":"crossref","unstructured":"Li X, Zeng F et al (2019) The positive effects of Grifola frondosa heteropolysaccharide on NAFLD and regulation of the gut microbiota. Int J Mol Sci 20(21):5302","DOI":"10.3390\/ijms20215302"},{"key":"2864_CR23","doi-asserted-by":"publisher","first-page":"45425","DOI":"10.1038\/srep45425","volume":"7","author":"DW Lim","year":"2017","unstructured":"Lim DW, Bose S et al (2017) Modified SJH alleviates FFAs-induced hepatic steatosis through leptin signaling pathways. Sci Rep 7:45425","journal-title":"Sci Rep"},{"key":"2864_CR24","doi-asserted-by":"crossref","unstructured":"Martinez-Montoro JI, Cornejo-Pareja\u00a0I et al (2021) Impact of genetic polymorphism on response to therapy in non-alcoholic fatty liver disease. Nutrients 13(11):4077","DOI":"10.3390\/nu13114077"},{"issue":"3","key":"2864_CR25","doi-asserted-by":"publisher","first-page":"190","DOI":"10.3164\/jcbn.13-74","volume":"54","author":"H Miyazaki","year":"2014","unstructured":"Miyazaki H, Takitani K et al (2014) The alpha-tocopherol status and expression of alpha-tocopherol-related proteins in methionine-choline deficient rats treated with vitamin E. J Clin Biochem Nutr 54(3):190\u2013197","journal-title":"J Clin Biochem Nutr"},{"key":"2864_CR26","doi-asserted-by":"crossref","unstructured":"Niesor EJ, Nader\u00a0E et al (2022) Red blood cell membrane cholesterol may be a key regulator of sickle cell disease microvascular complications. Membranes (Basel) 12(11):1134","DOI":"10.3390\/membranes12111134"},{"key":"2864_CR27","doi-asserted-by":"crossref","unstructured":"Ormanji MS, Rodrigues\u00a0FG et al (2020) Dietary recommendations for bariatric patients to prevent kidney stone formation. Nutrients 12(5):1442","DOI":"10.3390\/nu12051442"},{"key":"2864_CR28","doi-asserted-by":"crossref","unstructured":"Perdomo CM, Fruhbeck\u00a0G et al (2019) Impact of nutritional changes on nonalcoholic fatty liver disease. Nutrients 11(3):677","DOI":"10.3390\/nu11030677"},{"key":"2864_CR29","doi-asserted-by":"crossref","unstructured":"Perumpail BJ, Li\u00a0AA et al (2018) The role of vitamin E in the treatment of NAFLD. Diseases 6(4):86","DOI":"10.3390\/diseases6040086"},{"key":"2864_CR30","doi-asserted-by":"publisher","first-page":"3886710","DOI":"10.1155\/2022\/3886710","volume":"2022","author":"S Pramanik","year":"2022","unstructured":"Pramanik S, Banerjee K et al (2022) The amelioration of detrimental biochemical anomalies by supplementing B, C, and E vitamins in subjects with type 2 diabetes mellitus may reduce the rate of development of diabetic retinopathy. J Diabetes Res 2022:3886710","journal-title":"J Diabetes Res"},{"issue":"3","key":"2864_CR31","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.jcmgh.2017.12.009","volume":"5","author":"M Rojo de la Vega","year":"2018","unstructured":"Rojo de la Vega M, Zhang DD (2018) NRF2 induction for NASH treatment: a new hope rises. Cell Mol Gastroenterol Hepatol 5(3):422\u2013423","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"12","key":"2864_CR32","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1007\/s13361-016-1469-y","volume":"27","author":"AC Schrimpe-Rutledge","year":"2016","unstructured":"Schrimpe-Rutledge AC, Codreanu SG et al (2016) Untargeted metabolomics strategies-challenges and emerging directions. J Am Soc Mass Spectrom 27(12):1897\u20131905","journal-title":"J Am Soc Mass Spectrom"},{"issue":"7","key":"2864_CR33","first-page":"897","volume":"16","author":"QZ Shi","year":"2010","unstructured":"Shi QZ, Wang LW et al (2010) Betaine inhibits toll-like receptor 4 expression in rats with ethanol-induced liver injury. World J Gastroenterol 16(7):897\u2013903","journal-title":"World J Gastroenterol"},{"issue":"1","key":"2864_CR34","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.atherosclerosis.2010.07.051","volume":"213","author":"AB Waqar","year":"2010","unstructured":"Waqar AB, Koike T et al (2010) High-fat diet without excess calories induces metabolic disorders and enhances atherosclerosis in rabbits. Atherosclerosis 213(1):148\u2013155","journal-title":"Atherosclerosis"},{"issue":"1","key":"2864_CR35","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/s12944-019-1118-0","volume":"18","author":"RX Yang","year":"2019","unstructured":"Yang RX, Pan Q et al (2019) Therapeutic effect and autophagy regulation of myriocin in nonalcoholic steatohepatitis. Lipids Health Dis 18(1):179","journal-title":"Lipids Health Dis"},{"issue":"3","key":"2864_CR36","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1080\/00071668.2021.2008313","volume":"63","author":"M Yang","year":"2022","unstructured":"Yang M, Chen R et al (2022) Effects of dietary betaine supplementation on growth performance, meat quality, muscle fatty acid composition and antioxidant ability in slow-growing broiler chickens. Br Poult Sci 63(3):351\u2013359","journal-title":"Br Poult Sci"},{"key":"2864_CR37","doi-asserted-by":"publisher","first-page":"6659445","DOI":"10.1155\/2021\/6659445","volume":"2021","author":"Y Ying","year":"2021","unstructured":"Ying Y, Zhang H et al (2021) Gegen Qinlian decoction ameliorates nonalcoholic fatty liver disease in rats via oxidative stress, inflammation, and the NLRP3 signal axis. Evid Based Complement Alternat Med 2021:6659445","journal-title":"Evid Based Complement Alternat Med"},{"key":"2864_CR38","doi-asserted-by":"crossref","unstructured":"Zhao X, Song JL et al (2018) Comparison of antioxidative effects of insect tea and its raw tea (Kuding tea) polyphenols in Kunming mice. Molecules 23(1):204","DOI":"10.3390\/molecules23010204"},{"key":"2864_CR39","doi-asserted-by":"publisher","first-page":"1076123","DOI":"10.3389\/fmicb.2022.1076123","volume":"13","author":"Y Zhu","year":"2022","unstructured":"Zhu Y, Cidan Y et al (2022) Different feeding patterns affect meat quality of Tibetan pigs associated with intestinal microbiota alterations. Front Microbiol 13:1076123","journal-title":"Front Microbiol"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-023-02864-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-023-02864-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-023-02864-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T08:18:08Z","timestamp":1716365888000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-023-02864-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,13]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["2864"],"URL":"https:\/\/doi.org\/10.1007\/s00210-023-02864-0","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,13]]},"assertion":[{"value":"9 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal care procedures were proceeded in keeping with protocols approved by the Hangzhou Normal University Institutional Committee on Animal Care and Use (HSD20220203). All experiments complied with the Guide for the Care and Use of Laboratory Animals and the National Institutes of Health Guide for the Care and Use of Laboratory Animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}