{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:34:25Z","timestamp":1785551665630,"version":"3.56.0"},"reference-count":78,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T00:00:00Z","timestamp":1702684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T00:00:00Z","timestamp":1702684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Medizinische Hochschule Hannover (MHH)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>For several decades, reserpine was used to treat hypertension and, to a limited extent, psychoses. Over time, however, the indication became more and more restricted to the point of obsolescence. This study examines the extent to which textbooks are up to date in their content and oriented towards therapeutic guidelines, using the obsolete drug reserpine as a paradigm. Three German pharmacology textbook series were examined for the coverage of reserpine from 1964-2023: <jats:italic>Allgemeine und Spezielle Pharmakologie und Toxikologie<\/jats:italic> (Aktories), <jats:italic>Allgemeine und Spezielle Pharmakologie und Toxikologie<\/jats:italic> (Karow) and <jats:italic>Pharmakologie und Toxikologie<\/jats:italic> (L\u00fcllmann). We compared the textbook content with data on reserpine prescriptions and hypertension guidelines and analysed the relevance of reserpine in examinations using German federal exam questions by the Institute for medical and pharmaceutical exam questions (IMPP). The textbooks differ conceptually\u00a0from each other. The indication of reserpine for hypertension has become more restricted over time\u00a0in all three\u00a0textbooks, yet they partially show discrepancies with hypertension guidelines. The reserpine\u00a0prescription figures show a strong decline , and reserpine has not been queried by the IMPP, which underlines the  obsolescence\u00a0of the drug. Overall, our study shows that the  presentation\u00a0of a representative obsolete drug in pharmacology textbooks lags current medical practice. We also unmasked more differences in the presentation of an obsolete drug in standard textbooks than anticipated. In conclusion, the analysis of obsolete drugs in pharmacology textbooks is an informative way of assessing how up-to-date they are.<\/jats:p>","DOI":"10.1007\/s00210-023-02877-9","type":"journal-article","created":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T08:01:30Z","timestamp":1702713690000},"page":"4381-4401","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Presentation of the obsolete drug reserpine in three German-language pharmacology textbooks"],"prefix":"10.1007","volume":"397","author":[{"given":"Nikolas","family":"Misera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Seifert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,16]]},"reference":[{"key":"2877_CR1","unstructured":"Arzneimittelkommission der deutschen \u00c4rzteschaft (2004) Arterielle Hypertonie 2nd edition. https:\/\/www.reanitrain.de\/downloads\/leitlinien\/Notfaelle\/internistische%20Notfaelle\/zirkulatorische%20Notfaelle\/Hypertonie%20-%20hypertensive%20Krise\/Arterielle%20Hypertonie.pdf Accessed 11 October 2023"},{"key":"2877_CR2","unstructured":"Aktories K, F\u00f6rstermann U, Hofmann F, Starke K (2004) Allgemeine und spezielle Pharmakologie und Toxikologie, (9th edn. 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