{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:32:45Z","timestamp":1785515565188,"version":"3.56.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the research was to evaluate the influence of antagonists of specific beta-adrenergic receptor subtypes on bowel motility following abdominal surgery in rat model of postoperative ileus. Bowel motility was measured by the intestinal transit of Evans blue introduced via orogastric tube after surgical procedures of skin incision, laparotomy and laparotomy with gut manipulation. Male rats were given individual adrenergic receptor subtypes antagonists intraperitoneally, and the influence of administered agents on intestinal transit of Evans blue was then evaluated. No statistically significant differences in the length of intestine in tested rats were observed. Propranolol administered prior to surgical procedure has shown protective effect on Evans blue migration in rats undergoing laparotomy and gut manipulation. Intestinal dye transit for propranolol doses of 10, 30 and 45 mg\/kg was 18.00 \u00b1 1.88c m, 23.75 \u00b1 1.71 cm and 22.5 \u00b1 2.43 cm, respectively, and for last two doses, statistically significant increase of dye passage was noted, compared to Evans blue transit of 11.00 \u00b1 2.43 cm in the control group. No acceleration of dye migration was seen following administration of beta1-, beta2- and beta3-selective adrenergic receptor antagonist metoprolol, ICI 118.551 and SR58894A, respectively. Our research confirmed that propranolol at high doses, as seen by other researchers, improved bowel motility in early phase of postoperative ileus. That slight acceleration of intestinal dye transit after surgery with gut manipulation is rather connected with membrane-stabilizing action, than the receptor blocking effect, as this effect was not observed after the application of selective antagonists of respective subtypes of beta-adrenergic receptor.<\/jats:p>","DOI":"10.1007\/s00210-023-02918-3","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T10:02:46Z","timestamp":1703844166000},"page":"4851-4857","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The role of beta-adrenoreceptors in postoperative ileus in rats"],"prefix":"10.1007","volume":"397","author":[{"given":"Bitel","family":"Marcin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sztormowska-Achranowicz","family":"Katarzyna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7363-5475","authenticated-orcid":false,"given":"Koci\u0107","family":"Ivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,29]]},"reference":[{"key":"2918_CR1","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/bs.podrm.2017.02.006","volume":"42","author":"AA Al-Majed","year":"2017","unstructured":"Al-Majed AA, Bakheit AHH, Abdel Aziz HA, Alajmi FM, AlRabiah H (2017) Propranolol. Profiles Drug Subst Excip Relat Methodol 42:287\u2013338. https:\/\/doi.org\/10.1016\/bs.podrm.2017.02.006","journal-title":"Profiles Drug Subst Excip Relat Methodol"},{"issue":"2","key":"2918_CR2","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/0006-2952(96)00212-2","volume":"52","author":"R Anderson","year":"1996","unstructured":"Anderson R, Ramafi G, Theron AJ (1996) Membrane stabilizing, anti-oxidative interactions of propranolol and dexpropranolol with neutrophils. Biochem Pharmacol 26 52(2):341\u20139. https:\/\/doi.org\/10.1016\/0006-2952(96)00212-2","journal-title":"Biochem Pharmacol 26"},{"key":"2918_CR3","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/j.1743-3150.2004.00558.x","volume":"2","author":"AJ Bauer","year":"2004","unstructured":"Bauer AJ, Boeckxstaens GE (2004) Mechanisms of postoperative ileus. Neurogastroenterol Motil 2:54\u201360. https:\/\/doi.org\/10.1111\/j.1743-3150.2004.00558.x","journal-title":"Neurogastroenterol Motil"},{"issue":"8","key":"2918_CR4","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1007\/BF01072353","volume":"23","author":"L Bueno","year":"1978","unstructured":"Bueno L, Ferre JP, Ruckebusch Y (1978) Effects of anaesthesia and surgical procedure on intestinal myoelectric activity in rats. Am J Dig Dis 23(8):690\u20135. https:\/\/doi.org\/10.1007\/BF01072353","journal-title":"Am J Dig Dis"},{"issue":"2","key":"2918_CR5","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jss.2006.01.006","volume":"133","author":"R Ciechanownicz","year":"2006","unstructured":"Ciechanownicz R, Sein-Anand J, Chodorowski Z, Bitel M, Petrusewicz J, Korolkiewicz RP (2006) Salutary effects of tachykinin receptor antagonists in a rat model of postoperative ileus. J Surg Res 15 133(2):197\u2013202. https:\/\/doi.org\/10.1016\/j.jss.2006.01.006","journal-title":"J Surg Res 15"},{"key":"2918_CR6","doi-asserted-by":"publisher","unstructured":"De Winter BY, Boeckxstaens GE, De Man JG, Moreels TG, Herman AG, Pelckmans PA (1997) Effects of mu- and kappa opioid receptors on postoperative ileus in rats. Eur J Pharmacol 339(1):63\u20137. https:\/\/doi.org\/10.1016\/s0014-2999(97)01345-9","DOI":"10.1016\/s0014-2999(97)01345-9"},{"issue":"4","key":"2918_CR7","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1159\/000050157","volume":"18","author":"AA Ferraz","year":"2001","unstructured":"Ferraz AA, Wanderley GJ, Santos MA Jr, Mathias CA, Ara\u00fajo JG Jr, Ferraz EM (2001) Effects of propranolol on human postoperative ileus. Dig Surg 18(4):305\u201310. https:\/\/doi.org\/10.1159\/000050157","journal-title":"Dig Surg"},{"key":"2918_CR8","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/j.1365-2982.2004.00602.x","volume":"17","author":"H Fukuda","year":"2005","unstructured":"Fukuda H, Tsuchida D, Koda K, Miyazaki M, Pappas TN, Takahashi T (2005) Impaired gastric motor activity after abdominal surgery in rats. Neurogastroenterol Motil 17:245\u201350. https:\/\/doi.org\/10.1111\/j.1365-2982.2004.00602.x","journal-title":"Neurogastroenterol Motil"},{"issue":"2","key":"2918_CR9","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3109\/00365528708991872","volume":"22","author":"B Hallerb\u00e4ck","year":"1987","unstructured":"Hallerb\u00e4ck B, Carlsen E, Carlsson K, Enkvist C, Glise H, Haffner J, Innes R, Kirn\u00f6 K (1987) Beta-adrenoceptor blockade in the treatment of postoperative adynamic ileus. Scand J Gastroenterol 22(2):149\u201355. https:\/\/doi.org\/10.3109\/00365528708991872","journal-title":"Scand J Gastroenterol"},{"key":"2918_CR10","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1055\/s-0038-1677003","volume":"32","author":"CR Harnsberger","year":"2019","unstructured":"Harnsberger CR, Maykel JA, Alavi K (2019) Postoperative ileus. Clin Colon Rectal Surg 32:166\u2013170. https:\/\/doi.org\/10.1055\/s-0038-1677003","journal-title":"Postoperative ileus. Clin Colon Rectal Surg"},{"issue":"4","key":"2918_CR11","first-page":"152","volume":"68","author":"K Holte","year":"2002","unstructured":"Holte K, Kehlet H (2002) Prevention of postoperative ileus. Minerva anestesiologica 68(4):152\u2013156","journal-title":"Minerva anestesiologica"},{"key":"2918_CR12","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1053\/gast.1999.0029900378","volume":"117","author":"JC Kalff","year":"1999","unstructured":"Kalff JC, Carlos TM, Schraut WH, Billiar TR, Simmons RL, Bauer AJ (1999) Surgically induced leukocytic infiltrates within the rat intestinal muscularis mediate postoperative ileus. Gastroenterology 117:378\u201387. https:\/\/doi.org\/10.1053\/gast.1999.0029900378","journal-title":"Gastroenterology"},{"issue":"2","key":"2918_CR13","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/s0022-4804(02)00095-1","volume":"109","author":"RP Korolkiewicz","year":"2003","unstructured":"Korolkiewicz RP, Ujda M, D\u0105bkowski J, Ruczy\u0144ski J, Rekowski P, Petrusewicz J (2003) Differential salutary effects of nonselective and selective COX-2 inhibitors in postoperative ileus in rats. Journal of Surgical Research 109(2):161\u2013169. https:\/\/doi.org\/10.1016\/s0022-4804(02)00095-1","journal-title":"Journal of Surgical Research"},{"issue":"3","key":"2918_CR14","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.gassur.2003.11.004","volume":"8","author":"RP Korolkiewicz","year":"2004","unstructured":"Korolkiewicz RP, Sein-Anand J, Ruczy\u0144ski J, Rekowski P, Bieniaszewski L, Chodorowski Z, Petrusewicz J, Ujda M, Dabkowski J, Bitel M, Kato S, Takeuchi K (2004) The role and interactions of nitric oxide (NO), carbon monoxide (CO), and prostanoids in the pathogenesis of postoperative ileus in rats. J Gastrointest Surg 8(3):346\u201357. https:\/\/doi.org\/10.1016\/j.gassur.2003.11.004","journal-title":"J Gastrointest Surg"},{"issue":"4","key":"2918_CR15","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1136\/gut.52.4.527","volume":"52","author":"C Kreiss","year":"2003","unstructured":"Kreiss C, Birder LA, Kiss S, VanBibber MM, Bauer AJ (2003) COX-2 dependent inflammation increases spinal Fos expression during rodent postoperative ileus. Gut 52(4):527\u201334. https:\/\/doi.org\/10.1136\/gut.52.4.527","journal-title":"Gut"},{"key":"2918_CR16","doi-asserted-by":"publisher","first-page":"583422","DOI":"10.3389\/fphar.2020.583422","volume":"11","author":"E Mazzotta","year":"2020","unstructured":"Mazzotta E, Villalobos-Hernandez EC, Fiorda-Diaz J, Harzman A, Christofi FL (2020) Postoperative ileus and postoperative gastrointestinal tract dysfunction: pathogenic mechanisms and novel treatment strategies beyond colorectal enhanced recovery after surgery protocols. Front Pharmacol 11:583422. https:\/\/doi.org\/10.3389\/fphar.2020.583422","journal-title":"Front Pharmacol"},{"issue":"1","key":"2918_CR17","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s12893-021-01093-7","volume":"21","author":"Y Namba","year":"2021","unstructured":"Namba Y, Hirata Y, Mukai S, Okimoto S, Fujisaki S, Takahashi M et al (2021) Clinical indicators for the incidence of postoperative ileus after elective surgery for colorectal cancer. BMC Surg 21(1):80. https:\/\/doi.org\/10.1186\/s12893-021-01093-7","journal-title":"BMC Surg"},{"issue":"11","key":"2918_CR18","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/0192-0561(94)90045-0","volume":"16","author":"HM Shen","year":"1994","unstructured":"Shen HM, Sha LX, Kennedy JL, Ou DW (1994) Adrenergic receptors regulate macrophage secretion. Int J Immunopharmacol 16(11):905\u201310. https:\/\/doi.org\/10.1016\/0192-0561(94)90045-0","journal-title":"Int J Immunopharmacol"},{"key":"2918_CR19","doi-asserted-by":"publisher","unstructured":"Uemura K, Tatewaki M, Harris MB, Ueno T, Mantyh CR, Pappas TN, Takahashi T (2004) Magnitude of abdominal incision affects the duration of postoperative ileus in rats. Surg Endosc. 18(4):606\u201310. https:\/\/doi.org\/10.1007\/s00464-003-8161-6","DOI":"10.1007\/s00464-003-8161-6"},{"key":"2918_CR20","doi-asserted-by":"publisher","first-page":"144","DOI":"10.3389\/fphar.2010.00144","volume":"1","author":"DW Wang","year":"2010","unstructured":"Wang DW, Mistry AM, Kahlig KM, Kearney JA, Xiang J, George AL Jr (2010) Propranolol blocks cardiac and neuronal voltage-gated sodium channels. Front Pharmacol 1:144. https:\/\/doi.org\/10.3389\/fphar.2010.00144","journal-title":"Front Pharmacol"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-023-02918-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-023-02918-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-023-02918-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T13:24:14Z","timestamp":1718112254000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-023-02918-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,29]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["2918"],"URL":"https:\/\/doi.org\/10.1007\/s00210-023-02918-3","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,29]]},"assertion":[{"value":"19 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures were performed according to the generally accepted ethical standards, comply with the ARRIVE guidelines and were in accordance with the U.K. Animals (Scientific Procedures) Act, 1986 and associated guidelines, EU Directive 2010\/63\/EU for animal experiments. Additionally, experiments were approved by the Local Ethics Committee for Animal Experiments No 3, Medical University of Gdansk.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}