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In this study, the protective effect of losartan in hepatotoxicity and nephrotoxicity induced by acetaminophen in mice was investigated owing to its anti-inflammatory and antioxidant effects.\u00a0An injection of a single dose of 500 mg\/kg (i.p.) acetaminophen was administered to induce hepatotoxicity and nephrotoxicity in Groups VI\u2013X. Losartan at doses of 1 mg\/kg (Group VII), 3 mg\/kg (Group VIII), and 10 mg\/kg (Groups III, V, IX, and X) was injected intraperitoneally twice, at 1 and 12 h after the acetaminophen injection. Additionally, a 4 mg\/kg dose of GW9662 (peroxisome proliferator-activated receptor gamma (PPAR-\u03b3) antagonist) was injected intraperitoneally 30 min before the losartan injections in Groups V and X. At the end of 24 h, the mice were euthanized, and blood, liver, and kidney tissue samples were collected. Levels of AST, ALT, creatinine, and oxidative stress markers including TBARS, SOD, CAT, GPx, TAS, TOS, GSH, and GSSG, along with pro-inflammatory cytokines IL-1\u03b2, IL-6, IL-8, IL-10, IL-17, and TNF-\u03b1, were measured using ELISA kits. Additionally, a histological evaluation of the tissue samples was performed.\u00a0Acetaminophen causes increases in the levels of AST, ALT, creatinine, TBARS, TOS, GSSG, IL-1\u03b2, IL-6, IL-8, IL-10, IL-17, and TNF-\u03b1 in serum, liver, and kidney tissue. Meanwhile, it led to a decrease in the levels of SOD, CAT, GPx, TAS, and GSH. Losartan injection reversed oxidative and inflammatory damage induced by acetaminophen. Histopathological changes in liver and kidney tissue were alleviated by losartan. The substance GW9662 increased the protective effect of losartan.\u00a0In light of all the data obtained from our study, it can be said that losartan has a protective effect on liver and kidney damage induced by acetaminophen due to its antioxidant and anti-inflammatory effects. In terms of the study, losartan was found to be an alternative substance that could protect people from the harmful effects of acetaminophen.<\/jats:p>","DOI":"10.1007\/s00210-023-02937-0","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T06:02:23Z","timestamp":1704780143000},"page":"5067-5078","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Evaluation of the protective effect of losartan in acetaminophen-induced liver and kidney damage in mice"],"prefix":"10.1007","volume":"397","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7000-6342","authenticated-orcid":false,"given":"Serkan","family":"\u015eahin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u00e7a \u00c7akmak","family":"Ayd\u0131n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe Ye\u015fim","family":"G\u00f6\u00e7men","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emin","family":"Kaymak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,9]]},"reference":[{"key":"2937_CR1","doi-asserted-by":"publisher","first-page":"3209","DOI":"10.53350\/pjmhs2115123209","volume":"15","author":"A Abbasi","year":"2021","unstructured":"Abbasi A, Mawani H, Pathan GN et al (2021) Hepatoprotective role of virgin coconut oil and neem extract in acetaminophen \u0131nduced liver toxicity. 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