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Four groups, each comprising eight rats, were established: control, LPS, LPS + NEB, and NEB. Biochemical analyses included total oxidant status (TOS), serum aspartate transaminase (AST), and alanine aminotransferase (ALT) levels. Additionally, genetic assessments involved\n                    <jats:italic>Chop<\/jats:italic>\n                    and\n                    <jats:italic>Bip<\/jats:italic>\n                    \/\n                    <jats:italic>GRP78<\/jats:italic>\n                    mRNA expression levels, while histopathological examinations were conducted. Immunohistochemistry was used to determine interleukin-1 beta (IL-1 \u03b2) and caspase-3 levels. The LPS group exhibited significantly higher AST, ALT, oxidative stress index, and TOS levels compared to the control group. Moreover, the LPS group demonstrated markedly increased\n                    <jats:italic>Chop<\/jats:italic>\n                    and\n                    <jats:italic>Bip<\/jats:italic>\n                    \/\n                    <jats:italic>GRP78<\/jats:italic>\n                    mRNA expression compared to the control group. Immunohistochemical analysis of the LPS group revealed significant upregulation in IL-1\u03b2 and caspase-3 expressions compared to the control group. Additionally, the LPS group showed significant hyperemia, mild hemorrhage, and inflammatory cell infiltrations. Comparatively, the LPS+NEB group exhibited a reversal of these alterations when compared to the LPS group. Collectively, our findings, suggest that NEB holds promise as a treatment in conditions where oxidative damage, inflammation, and ER stress\u2013related apoptosis play significant roles in the pathogenesis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s00210-024-02990-3","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T04:02:21Z","timestamp":1707883341000},"page":"5899-5907","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Nebivolol protects the liver against lipopolysaccharide-induced oxidative stress, inflammation, and endoplasmic reticulum\u2013related apoptosis through Chop and Bip\/GRP78 signaling"],"prefix":"10.1007","volume":"397","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0409-4476","authenticated-orcid":false,"given":"Onur","family":"Unal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalcin","family":"Erzurumlu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halil","family":"Asci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berivan","family":"Gunduru Acar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Bedir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem","family":"Ozmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,14]]},"reference":[{"key":"2990_CR1","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s00296-007-0452-0","volume":"28","author":"O Altindag","year":"2008","unstructured":"Altindag O, Erel O, Soran N, Celik H, Selek S (2008) Total oxidative\/anti-oxidative status and relation to bone mineral density in osteoporosis. 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