{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:30:15Z","timestamp":1790818215851,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Chinese Stroke Association","award":["2020017"],"award-info":[{"award-number":["2020017"]}]},{"name":"Chinese Stroke Association","award":["2020017"],"award-info":[{"award-number":["2020017"]}]},{"name":"Chinese Stroke Association","award":["2020017"],"award-info":[{"award-number":["2020017"]}]},{"name":"Chinese Stroke Association","award":["2020017"],"award-info":[{"award-number":["2020017"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1007\/s00210-024-03045-3","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T04:02:23Z","timestamp":1710475343000},"page":"6647-6659","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Edaravone dexborneol promotes M2 microglia polarization against lipopolysaccharide-induced inflammation via suppressing TLR4\/MyD88\/NF-\u03baB pathway"],"prefix":"10.1007","volume":"397","author":[{"given":"Jing","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanqin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daokai","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,15]]},"reference":[{"key":"3045_CR1","doi-asserted-by":"publisher","unstructured":"Aluri J, Cooper MA, Schuettpelz LG (2021) Toll-like receptor signaling in the establishment and function of the immune system. Cells 10(6). https:\/\/doi.org\/10.3390\/cells10061374.","DOI":"10.3390\/cells10061374"},{"issue":"6","key":"3045_CR2","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1002\/glia.22654","volume":"62","author":"K Biber","year":"2014","unstructured":"Biber K, Owens T, Boddeke E (2014) What is microglia neurotoxicity (Not)? Glia 62(6):841\u2013854. https:\/\/doi.org\/10.1002\/glia.22654","journal-title":"Glia"},{"issue":"10","key":"3045_CR3","doi-asserted-by":"publisher","first-page":"2194","DOI":"10.1016\/j.immuni.2021.09.014","volume":"54","author":"K Borst","year":"2021","unstructured":"Borst K, Dumas AA, Prinz M (2021) Microglia: immune and non-immune functions. Immunity 54(10):2194\u20132208. https:\/\/doi.org\/10.1016\/j.immuni.2021.09.014","journal-title":"Immunity"},{"issue":"10","key":"3045_CR4","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/s41583-018-0057-5","volume":"19","author":"O Butovsky","year":"2018","unstructured":"Butovsky O, Weiner HL (2018) Microglial signatures and their role in health and disease. Nat Rev Neurosci 19(10):622\u2013635. https:\/\/doi.org\/10.1038\/s41583-018-0057-5","journal-title":"Nat Rev Neurosci"},{"issue":"8","key":"3045_CR5","doi-asserted-by":"publisher","first-page":"2736","DOI":"10.4049\/jimmunol.149.8.2736","volume":"149","author":"CC Chao","year":"1992","unstructured":"Chao CC, Hu S, Molitor TW, Shaskan EG, Peterson PK (1992) Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J Immunol 149(8):2736\u20132741","journal-title":"J Immunol"},{"issue":"4","key":"3045_CR6","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1007\/s00018-020-03656-y","volume":"78","author":"A Ciesielska","year":"2021","unstructured":"Ciesielska A, Matyjek M, Kwiatkowska K (2021) TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling. Cell Mol Life Sci 78(4):1233\u20131261. https:\/\/doi.org\/10.1007\/s00018-020-03656-y","journal-title":"Cell Mol Life Sci"},{"issue":"4","key":"3045_CR7","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/j.neuroscience.2005.06.035","volume":"135","author":"S Duport","year":"2005","unstructured":"Duport S, Garthwaite J (2005) Pathological consequences of inducible nitric oxide synthase expression in hippocampal slice cultures. Neuroscience 135(4):1155\u20131166. https:\/\/doi.org\/10.1016\/j.neuroscience.2005.06.035","journal-title":"Neuroscience"},{"key":"3045_CR8","doi-asserted-by":"publisher","first-page":"113372","DOI":"10.1016\/j.ecoenv.2022.113372","volume":"234","author":"Z Fan","year":"2022","unstructured":"Fan Z, Zhang W, Cao Q, Zou L, Fan X, Qi C et al (2022) JAK2\/STAT3 pathway regulates microglia polarization involved in hippocampal inflammatory damage due to acute paraquat exposure. Ecotoxicol Environ Saf 234:113372. https:\/\/doi.org\/10.1016\/j.ecoenv.2022.113372","journal-title":"Ecotoxicol Environ Saf"},{"key":"3045_CR9","doi-asserted-by":"publisher","unstructured":"Han B, Li X, Ai RS, Deng SY, Ye ZQ, Deng X et al (2022) Atmospheric particulate matter aggravates CNS demyelination through involvement of TLR-4\/NF-kB signaling and microglial activation. Elife 11. https:\/\/doi.org\/10.7554\/eLife.72247.","DOI":"10.7554\/eLife.72247"},{"issue":"3","key":"3045_CR10","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","volume":"132","author":"MS Hayden","year":"2008","unstructured":"Hayden MS, Ghosh S (2008) Shared principles in NF-kappaB signaling. Cell 132(3):344\u2013362. https:\/\/doi.org\/10.1016\/j.cell.2008.01.020","journal-title":"Cell"},{"issue":"1","key":"3045_CR11","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s12974-018-1195-4","volume":"15","author":"Y He","year":"2018","unstructured":"He Y, Yao X, Taylor N, Bai Y, Lovenberg T, Bhattacharya A (2018) RNA sequencing analysis reveals quiescent microglia isolation methods from postnatal mouse brains and limitations of BV2 cells. J Neuroinflammation 15(1):153. https:\/\/doi.org\/10.1186\/s12974-018-1195-4","journal-title":"J Neuroinflammation"},{"issue":"10","key":"3045_CR12","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1038\/s41583-018-0055-7","volume":"19","author":"MT Heneka","year":"2018","unstructured":"Heneka MT, McManus RM, Latz E (2018) Inflammasome signalling in brain function and neurodegenerative disease. Nat Rev Neurosci 19(10):610\u2013621. https:\/\/doi.org\/10.1038\/s41583-018-0055-7","journal-title":"Nat Rev Neurosci"},{"issue":"Pt A","key":"3045_CR13","doi-asserted-by":"publisher","first-page":"109315","DOI":"10.1016\/j.intimp.2022.109315","volume":"113","author":"R Hu","year":"2022","unstructured":"Hu R, Liang J, Ding L, Zhang W, Liu X, Song B et al (2022) Edaravone dexborneol provides neuroprotective benefits by suppressing NLRP3 inflammasome-induced microglial pyroptosis in experimental ischemic stroke. Int Immunopharmacol 113(Pt A):109315. https:\/\/doi.org\/10.1016\/j.intimp.2022.109315","journal-title":"Int Immunopharmacol"},{"issue":"9","key":"3045_CR14","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1038\/s41423-021-00740-6","volume":"18","author":"Y Huang","year":"2021","unstructured":"Huang Y, Xu W, Zhou R (2021) NLRP3 inflammasome activation and cell death. Cell Mol Immunol 18(9):2114\u20132127. https:\/\/doi.org\/10.1038\/s41423-021-00740-6","journal-title":"Cell Mol Immunol"},{"issue":"5","key":"3045_CR15","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.3892\/mmr.2020.11003","volume":"21","author":"CT Jiang","year":"2020","unstructured":"Jiang CT, Wu WF, Deng YH, Ge JW (2020) Modulators of microglia activation and polarization in ischemic stroke (Review). Mol Med Rep 21(5):2006\u20132018. https:\/\/doi.org\/10.3892\/mmr.2020.11003","journal-title":"Mol Med Rep"},{"issue":"2","key":"3045_CR16","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/cmi.2015.95","volume":"13","author":"EK Jo","year":"2016","unstructured":"Jo EK, Kim JK, Shin DM, Sasakawa C (2016) Molecular mechanisms regulating NLRP3 inflammasome activation. Cell Mol Immunol 13(2):148\u2013159. https:\/\/doi.org\/10.1038\/cmi.2015.95","journal-title":"Cell Mol Immunol"},{"issue":"12","key":"3045_CR17","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/j.tins.2022.10.007","volume":"45","author":"O Kann","year":"2022","unstructured":"Kann O, Almouhanna F, Chausse B (2022) Interferon gamma: a master cytokine in microglia-mediated neural network dysfunction and neurodegeneration. Trends Neurosci 45(12):913\u2013927. https:\/\/doi.org\/10.1016\/j.tins.2022.10.007","journal-title":"Trends Neurosci"},{"issue":"1","key":"3045_CR18","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s40035-020-00221-2","volume":"9","author":"HS Kwon","year":"2020","unstructured":"Kwon HS, Koh SH (2020) Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes. Transl Neurodegener 9(1):42. https:\/\/doi.org\/10.1186\/s40035-020-00221-2","journal-title":"Transl Neurodegener"},{"key":"3045_CR19","doi-asserted-by":"publisher","first-page":"691773","DOI":"10.3389\/fphar.2021.691773","volume":"12","author":"J Li","year":"2021","unstructured":"Li J, Dai X, Zhou L, Li X, Pan D (2021) Edaravone plays protective effects on LPS-induced microglia by switching M1\/M2 phenotypes and regulating NLRP3 inflammasome activation. Front Pharmacol 12:691773. https:\/\/doi.org\/10.3389\/fphar.2021.691773","journal-title":"Front Pharmacol"},{"issue":"12","key":"3045_CR20","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1111\/cns.13261","volume":"25","author":"ZJ Liu","year":"2019","unstructured":"Liu ZJ, Ran YY, Qie SY, Gong WJ, Gao FH, Ding ZT et al (2019) Melatonin protects against ischemic stroke by modulating microglia\/macrophage polarization toward anti-inflammatory phenotype through STAT3 pathway. CNS Neurosci Ther 25(12):1353\u20131362. https:\/\/doi.org\/10.1111\/cns.13261","journal-title":"CNS Neurosci Ther"},{"key":"3045_CR21","doi-asserted-by":"publisher","unstructured":"Merighi S, Nigro M, Travagli A, Gessi S (2022) Microglia and Alzheimer\u2019s disease. Int J Mol Sci 23(21). https:\/\/doi.org\/10.3390\/ijms232112990.","DOI":"10.3390\/ijms232112990"},{"key":"3045_CR22","doi-asserted-by":"publisher","unstructured":"Pajares MI, Rojo A, Manda G, Bosca L, Cuadrado A (2020) Inflammation in Parkinson\u2019s disease: mechanisms and therapeutic implications. Cells 9(7). https:\/\/doi.org\/10.3390\/cells9071687.","DOI":"10.3390\/cells9071687"},{"key":"3045_CR23","doi-asserted-by":"publisher","unstructured":"Pan ML, Ahmad Puzi NN, Ooi YY, Ramasamy R, Vidyadaran S (2023) Response profiles of BV2 microglia to IFN-gamma and LPS co-stimulation and priming. Biomedicines 11(10). https:\/\/doi.org\/10.3390\/biomedicines11102648.","DOI":"10.3390\/biomedicines11102648"},{"issue":"1","key":"3045_CR24","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1073\/pnas.1513853113","volume":"113","author":"IE Papageorgiou","year":"2016","unstructured":"Papageorgiou IE, Lewen A, Galow LV, Cesetti T, Scheffel J, Regen T et al (2016) TLR4-activated microglia require IFN-gamma to induce severe neuronal dysfunction and death in situ. Proc Natl Acad Sci U S A 113(1):212\u2013217. https:\/\/doi.org\/10.1073\/pnas.1513853113","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3045_CR25","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1146\/annurev-immunol-093019-110159","volume":"39","author":"M Prinz","year":"2021","unstructured":"Prinz M, Masuda T, Wheeler MA, Quintana FJ (2021) Microglia and central nervous system-associated macrophages-from origin to disease modulation. Annu Rev Immunol 39:251\u2013277. https:\/\/doi.org\/10.1146\/annurev-immunol-093019-110159","journal-title":"Annu Rev Immunol"},{"key":"3045_CR26","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.molimm.2018.04.014","volume":"99","author":"QH Shao","year":"2018","unstructured":"Shao QH, Zhang XL, Chen Y, Zhu CG, Shi JG, Yuan YH et al (2018) Anti-neuroinflammatory effects of 20C from Gastrodia elata via regulating autophagy in LPS-activated BV-2 cells through MAPKs and TLR4\/Akt\/mTOR signaling pathways. Mol Immunol 99:115\u2013123. https:\/\/doi.org\/10.1016\/j.molimm.2018.04.014","journal-title":"Mol Immunol"},{"issue":"1","key":"3045_CR27","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1002\/ptr.7597","volume":"37","author":"H Shen","year":"2023","unstructured":"Shen H, He Z, Pei H, Zhai L, Guan Q, Wang G (2023) Aurantiamide promotes M2 polarization of microglial cells to improve the cognitive ability of mice with Alzheimer\u2019s disease. Phytother Res 37(1):101\u2013110. https:\/\/doi.org\/10.1002\/ptr.7597","journal-title":"Phytother Res"},{"key":"3045_CR28","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/1742-2094-9-115","volume":"9","author":"B Stansley","year":"2012","unstructured":"Stansley B, Post J, Hensley K (2012) A comparative review of cell culture systems for the study of microglial biology in Alzheimer\u2019s disease. J Neuroinflammation 9:115. https:\/\/doi.org\/10.1186\/1742-2094-9-115","journal-title":"J Neuroinflammation"},{"key":"3045_CR29","doi-asserted-by":"publisher","unstructured":"Stuckey SM, Ong LK, Collins-Praino LE, Turner RJ (2021) Neuroinflammation as a key driver of secondary neurodegeneration following stroke? Int J Mol Sci 22(23). https:\/\/doi.org\/10.3390\/ijms222313101.","DOI":"10.3390\/ijms222313101"},{"issue":"11","key":"3045_CR30","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/s41577-022-00684-6","volume":"22","author":"MG Tansey","year":"2022","unstructured":"Tansey MG, Wallings RL, Houser MC, Herrick MK, Keating CE, Joers V (2022) Inflammation and immune dysfunction in Parkinson disease. Nat Rev Immunol 22(11):657\u2013673. https:\/\/doi.org\/10.1038\/s41577-022-00684-6","journal-title":"Nat Rev Immunol"},{"key":"3045_CR31","doi-asserted-by":"publisher","first-page":"847440","DOI":"10.3389\/fnmol.2022.847440","volume":"15","author":"L Wang","year":"2022","unstructured":"Wang L, Ren W, Wu Q, Liu T, Wei Y, Ding J et al (2022) NLRP3 inflammasome activation: a therapeutic target for cerebral ischemia-reperfusion injury. Front Mol Neurosci 15:847440. https:\/\/doi.org\/10.3389\/fnmol.2022.847440","journal-title":"Front Mol Neurosci"},{"key":"3045_CR32","doi-asserted-by":"publisher","unstructured":"Williams LM, Gilmore TD (2020) Looking down on NF-kappaB. Mol Cell Biol 40(15). https:\/\/doi.org\/10.1128\/MCB.00104-20.","DOI":"10.1128\/MCB.00104-20"},{"key":"3045_CR33","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.ejphar.2014.06.035","volume":"740","author":"HY Wu","year":"2014","unstructured":"Wu HY, Tang Y, Gao LY, Sun WX, Hua Y, Yang SB et al (2014) The synergetic effect of edaravone and borneol in the rat model of ischemic stroke. Eur J Pharmacol 740:522\u2013531. https:\/\/doi.org\/10.1016\/j.ejphar.2014.06.035","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"3045_CR34","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1186\/s12974-022-02557-0","volume":"19","author":"Y Xie","year":"2022","unstructured":"Xie Y, Chen X, Li Y, Chen S, Liu S, Yu Z et al (2022) Transforming growth factor-beta1 protects against LPC-induced cognitive deficit by attenuating pyroptosis of microglia via NF-kappaB\/ERK1\/2 pathways. J Neuroinflammation 19(1):194. https:\/\/doi.org\/10.1186\/s12974-022-02557-0","journal-title":"J Neuroinflammation"},{"issue":"2","key":"3045_CR35","doi-asserted-by":"publisher","first-page":"466","DOI":"10.14336\/AD.2020.0701","volume":"12","author":"Y Xue","year":"2021","unstructured":"Xue Y, Nie D, Wang LJ, Qiu HC, Ma L, Dong MX et al (2021) Microglial polarization: novel therapeutic strategy against ischemic stroke. Aging Dis 12(2):466\u2013479. https:\/\/doi.org\/10.14336\/AD.2020.0701","journal-title":"Aging Dis"},{"key":"3045_CR36","doi-asserted-by":"publisher","first-page":"852416","DOI":"10.3389\/fimmu.2022.852416","volume":"13","author":"G Zhu","year":"2022","unstructured":"Zhu G, Wang X, Chen L, Lenahan C, Fu Z, Fang Y et al (2022) Crosstalk between the oxidative stress and glia cells after stroke: from mechanism to therapies. Front Immunol 13:852416. https:\/\/doi.org\/10.3389\/fimmu.2022.852416","journal-title":"Front Immunol"},{"issue":"1","key":"3045_CR37","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/s12974-019-1538-9","volume":"16","author":"M Zusso","year":"2019","unstructured":"Zusso M, Lunardi V, Franceschini D, Pagetta A, Lo R, Stifani S et al (2019) Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4\/NF-kB pathway. J Neuroinflammation 16(1):148. https:\/\/doi.org\/10.1186\/s12974-019-1538-9","journal-title":"J Neuroinflammation"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03045-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-024-03045-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03045-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T10:04:37Z","timestamp":1727172277000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-024-03045-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,15]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["3045"],"URL":"https:\/\/doi.org\/10.1007\/s00210-024-03045-3","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,15]]},"assertion":[{"value":"25 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}