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Kidney damage may develop from metabolic syndrome. Selenium (Se) participates in the structure of antioxidant enzymes and has a medicinal effect. In this work, the protective impact of Se on kidney damage produced by high-fructose corn syrup (HFCS) via endoplasmic reticulum (ER) stress was examined. The study comprised four groups, each consisting of ten experimental animals: control, HFCS (20%-HFCS), HFCS (20%-HFCS), + Se (0.3\u00a0mg\/kg\/day\/po), and Se (0.3\u00a0mg\/kg\/day\/po) alone. The duration of the experiment was 6 weeks. Kidney tissues were stained with hematoxylin and eosin for histological examination. Immunohistochemical analysis was conducted to assess TNF-\u03b1 and caspase-3 levels. The spectrophotometric evaluation was performed to measure TOS (total oxidant status), TAS (total antioxidant status), and OSI (oxidative stress index) levels. The PERK, ATF4, CHOP, BCL-2, and caspase-9 gene expression levels were assessed by the RT-qPCR method. After Se treatment, histopathological abnormalities and TNF-\u03b1 and caspase-3 levels in the HFCS+Se group decreased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). While TOS and OSI levels increased dramatically in the HFCS group, TAS values decreased significantly but improved after Se application (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The expression levels of the genes PERK, ATF4, CHOP, and caspase-9 were significantly lower in the HFCS group when compared to the HFCS+Se group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Our findings suggest that Se may protect against ER stress, oxidative stress, apoptosis, and kidney damage caused by high-dose fructose consumption.<\/jats:p>","DOI":"10.1007\/s00210-024-03149-w","type":"journal-article","created":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T17:01:21Z","timestamp":1715446881000},"page":"7829-7837","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The protective role of selenium against high-fructose corn syrup\u2013induced kidney damage: a histopathological and molecular analysis"],"prefix":"10.1007","volume":"397","author":[{"given":"Muhammet Yusuf","family":"Tepeba\u015f\u0131","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehtap","family":"Savran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samet","family":"Co\u015fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eerife A\u011f\u0131rca","family":"Ta\u015ftan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00fcnyamin","family":"Ayd\u0131n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,11]]},"reference":[{"key":"3149_CR1","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.cbi.2019.01.022","volume":"302","author":"EN Abd Al Haleem","year":"2019","unstructured":"Abd Al Haleem EN, El-Bakly WM (2019) The role of MAPK signaling pathway in selenium amelioration of high fat\/high cholesterol diet-induced tauopathy in rats. 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