{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:07:59Z","timestamp":1792782479316,"version":"4.5.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"2023 Yantai Science and Technology Innovation Plan","award":["2023YD019"],"award-info":[{"award-number":["2023YD019"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s00210-024-03168-7","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T11:02:06Z","timestamp":1716375726000},"page":"8053-8068","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Genistein promotes cartilage repair and inhibits synovial inflammatory response after anterior cruciate ligament transection in rats by regulating the Wnt\/\u03b2-catenin axis"],"prefix":"10.1007","volume":"397","author":[{"given":"Jianhang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfu","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"3168_CR1","doi-asserted-by":"publisher","unstructured":"Akeson G, Malemud CJ (2017) A role for soluble IL-6 receptor in osteoarthritis. J Func Morphol Kinesiol 2(3):27. https:\/\/doi.org\/10.3390\/jfmk2030027","DOI":"10.3390\/jfmk2030027"},{"key":"3168_CR2","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1007\/s00285-017-1104-y","volume":"75","author":"M Baker","year":"2017","unstructured":"Baker M, Brook BS, Owen MR (2017) Mathematical modelling of cytokines, MMPs and fibronectin fragments in osteoarthritic cartilage. J Mathematic Biol 75:985\u20131024. https:\/\/doi.org\/10.1007\/s00285-017-1104-y","journal-title":"J Mathematic Biol"},{"key":"3168_CR3","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.joca.2012.11.012","volume":"21","author":"F Berenbaum","year":"2013","unstructured":"Berenbaum F (2013) Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). Osteoarthritis Cartilage 21:16\u201321. https:\/\/doi.org\/10.1016\/j.joca.2012.11.012","journal-title":"Osteoarthritis Cartilage"},{"key":"3168_CR4","doi-asserted-by":"publisher","first-page":"10573","DOI":"10.7150\/thno.48666","volume":"10","author":"C Cao","year":"2020","unstructured":"Cao C, Wu F, Niu X, Hu X, Cheng J, Zhang Y, Li C, Duan X, Fu X, Zhang J, Zhang X, Ao Y (2020) Cadherin-11 cooperates with inflammatory factors to promote the migration and invasion of fibroblast-like synoviocytes in pigmented villonodular synovitis. Theranostics 10:10573\u201310588. https:\/\/doi.org\/10.7150\/thno.48666","journal-title":"Theranostics"},{"key":"3168_CR5","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/s41584-019-0221-y","volume":"15","author":"PG Conaghan","year":"2019","unstructured":"Conaghan PG, Cook AD, Hamilton JA, Tak PP (2019) Therapeutic options for targeting inflammatory osteoarthritis pain. Nat Rev Rheumatol 15:355\u2013363. https:\/\/doi.org\/10.1038\/s41584-019-0221-y","journal-title":"Nat Rev Rheumatol"},{"key":"3168_CR6","doi-asserted-by":"publisher","unstructured":"Cuzzocrea S, Mazzon E, Di Paola R, Mui\u00e0 C, Crisafulli C, Dugo L, Collin M, Britti D, Caputi AP, Thiemermann C (2006) Glycogen synthase kinase-3beta inhibition attenuates the degree of arthritis caused by type II collagen in the mouse. Clinical Immunol (Orlando, Fla.) 120:57\u201367 https:\/\/doi.org\/10.1016\/j.clim.2006.03.005","DOI":"10.1016\/j.clim.2006.03.005"},{"key":"3168_CR7","doi-asserted-by":"publisher","first-page":"R139","DOI":"10.1186\/ar2029","volume":"8","author":"F Dell\u2019accio","year":"2006","unstructured":"Dell\u2019accio F, De Bari C, El Tawil NM, Barone F, Mitsiadis TA, O\u2019Dowd J, Pitzalis C (2006) Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury. Arthritis Res Ther 8:R139. https:\/\/doi.org\/10.1186\/ar2029","journal-title":"Arthritis Res Ther"},{"key":"3168_CR8","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1002\/art.23444","volume":"58","author":"F Dell\u2019accio","year":"2008","unstructured":"Dell\u2019accio F, De Bari C, Eltawil NM, Vanhummelen P, Pitzalis C (2008) Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis. Arthritis Rheumat 58:1410\u201321. https:\/\/doi.org\/10.1002\/art.23444","journal-title":"Arthritis Rheumat"},{"key":"3168_CR9","doi-asserted-by":"publisher","first-page":"2480","DOI":"10.1159\/000430208","volume":"36","author":"G Du","year":"2015","unstructured":"Du G, Song Y, Wei L, Li L, Wang X, Xu Q, Zhan H, Cao Y, Zheng Y, Ding D (2015) Osthole inhibits proliferation and induces catabolism in rat chondrocytes and cartilage tissue. Cell Physiol Biochem Int J Exp Cell Physiol Biochem Pharmacol 36:2480\u201393. https:\/\/doi.org\/10.1159\/000430208","journal-title":"Cell Physiol Biochem Int J Exp Cell Physiol Biochem Pharmacol"},{"key":"3168_CR10","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1186\/s13287-018-0892-3","volume":"9","author":"B Gao","year":"2018","unstructured":"Gao B, Gao W, Wu Z, Zhou T, Qiu X, Wang X, Lian C, Peng Y, Liang A, Qiu J, Zhu Y, Xu C, Li Y, Su P, Huang D (2018) Melatonin rescued interleukin 1\u03b2-impaired chondrogenesis of human mesenchymal stem cells. Stem Cell Res Ther 9:162. https:\/\/doi.org\/10.1186\/s13287-018-0892-3","journal-title":"Stem Cell Res Ther"},{"key":"3168_CR11","doi-asserted-by":"publisher","first-page":"147588","DOI":"10.1016\/j.brainres.2021.147588","volume":"1768","author":"L Gao","year":"2021","unstructured":"Gao L, Yang L, Cui H (2021) GSK-3\u03b2 inhibitor TWS119 alleviates hypoxic-ischemic brain damage via a crosstalk with Wnt and Notch signaling pathways in neonatal rats. Brain Res 1768:147588. https:\/\/doi.org\/10.1016\/j.brainres.2021.147588","journal-title":"Brain Res"},{"key":"3168_CR12","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s00167-011-1818-0","volume":"20","author":"A Heijink","year":"2012","unstructured":"Heijink A, Gomoll AH, Madry H, Drobni\u010d M, Filardo G, Espregueira-Mendes J, Van Dijk CN (2012) Biomechanical considerations in the pathogenesis of osteoarthritis of the knee. Knee Surge Sports Traumatol Arthroscopy Off J ESSKA 20:423\u201335. https:\/\/doi.org\/10.1007\/s00167-011-1818-0","journal-title":"Knee Surge Sports Traumatol Arthroscopy Off J ESSKA"},{"key":"3168_CR13","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.immuni.2006.02.014","volume":"24","author":"X Hu","year":"2006","unstructured":"Hu X, Paik PK, Chen J, Yarilina A, Kockeritz L, Lu TT, Woodgett JR, Ivashkiv LB (2006) IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB\/AP-1 proteins. Immunity 24:563\u201374. https:\/\/doi.org\/10.1016\/j.immuni.2006.02.014","journal-title":"Immunity"},{"key":"3168_CR14","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.yexmp.2019.02.003","volume":"107","author":"H Hu","year":"2019","unstructured":"Hu H, Zhao C, Zhang P, Liu Y, Jiang Y, Wu E, Xue H, Liu C, Li Z (2019) miR-26b modulates OA induced BMSC osteogenesis through regulating GSK3\u03b2\/\u03b2-catenin pathway. Exp Mol Pathol 107:158\u2013164. https:\/\/doi.org\/10.1016\/j.yexmp.2019.02.003","journal-title":"Exp Mol Pathol"},{"key":"3168_CR15","doi-asserted-by":"publisher","first-page":"101865","DOI":"10.1016\/j.tice.2022.101865","volume":"78","author":"L Hu","year":"2022","unstructured":"Hu L, Luo D, Zhang H, He L (2022) Polydatin inhibits IL-1\u03b2-mediated chondrocyte inflammation and ameliorates cartilage degradation: involvement of the NF-\u03baB and Wnt\/\u03b2-catenin pathways. Tissue Cell 78:101865. https:\/\/doi.org\/10.1016\/j.tice.2022.101865","journal-title":"Tissue Cell"},{"key":"3168_CR16","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1016\/s0140-6736(19)30417-9","volume":"393","author":"DJ Hunter","year":"2019","unstructured":"Hunter DJ, Bierma-Zeinstra S (2019) Osteoarthritis. Lancet (London, England) 393:1745\u20131759. https:\/\/doi.org\/10.1016\/s0140-6736(19)30417-9","journal-title":"Lancet (London, England)"},{"key":"3168_CR17","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.orthres.2004.12.015","volume":"23","author":"YH Jean","year":"2005","unstructured":"Jean YH, Wen ZH, Chang YC, Huang GS, Lee HS, Hsieh SP, Wong CS (2005) Increased concentrations of neuro-excitatory amino acids in rat anterior cruciate ligament-transected knee joint dialysates: a microdialysis study. J Orthopaedic Res Off Public Orthopaedic Res Soc 23:569\u201375. https:\/\/doi.org\/10.1016\/j.orthres.2004.12.015","journal-title":"J Orthopaedic Res Off Public Orthopaedic Res Soc"},{"key":"3168_CR18","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.joca.2006.11.008","volume":"15","author":"YH Jean","year":"2007","unstructured":"Jean YH, Wen ZH, Chang YC, Hsieh SP, Tang CC, Wang YH, Wong CS (2007) Intra-articular injection of the cyclooxygenase-2 inhibitor parecoxib attenuates osteoarthritis progression in anterior cruciate ligament-transected knee in rats: role of excitatory amino acids. Osteoarthritis Cartilage 15:638\u201345. https:\/\/doi.org\/10.1016\/j.joca.2006.11.008","journal-title":"Osteoarthritis Cartilage"},{"key":"3168_CR19","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/s1063-4584(96)80004-5","volume":"4","author":"JR Kammermann","year":"1996","unstructured":"Kammermann JR, Kincaid SA, Rumph PF, Baird DK, Visco DM (1996) Tumor necrosis factor-alpha (TNF-alpha) in canine osteoarthritis: immunolocalization of TNF-alpha, stromelysin and TNF receptors in canine osteoarthritic cartilage. Osteoarthritis Cartilage 4:23\u201334. https:\/\/doi.org\/10.1016\/s1063-4584(96)80004-5","journal-title":"Osteoarthritis Cartilage"},{"key":"3168_CR20","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.2174\/1389450110607011377","volume":"7","author":"L Kockeritz","year":"2006","unstructured":"Kockeritz L, Doble B, Patel S, Woodgett JR (2006) Glycogen synthase kinase-3\u2013an overview of an over-achieving protein kinase. Curr Drug Targets 7:1377\u201388. https:\/\/doi.org\/10.2174\/1389450110607011377","journal-title":"Curr Drug Targets"},{"key":"3168_CR21","doi-asserted-by":"publisher","first-page":"106745","DOI":"10.1016\/j.intimp.2020.106745","volume":"86","author":"X Li","year":"2020","unstructured":"Li X, Mei W, Huang Z, Zhang L, Zhang L, Xu B, Shi X, Xiao Y, Ma Z, Liao T, Zhang H, Wang P (2020) Casticin suppresses monoiodoacetic acid-induced knee osteoarthritis through inhibiting HIF-1\u03b1\/NLRP3 inflammasome signaling. Int Immunopharmacol 86:106745. https:\/\/doi.org\/10.1016\/j.intimp.2020.106745","journal-title":"Int Immunopharmacol"},{"key":"3168_CR22","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1002\/art.38681","volume":"66","author":"GJ Litherland","year":"2014","unstructured":"Litherland GJ, Hui W, Elias MS, Wilkinson DJ, Watson S, Huesa C, Young DA, Rowan AD (2014) Glycogen synthase kinase 3 inhibition stimulates human cartilage destruction and exacerbates murine osteoarthritis. Arthritis Rheumatol (Hoboken, N.J.) 66:2175\u201387. https:\/\/doi.org\/10.1002\/art.38681","journal-title":"Arthritis Rheumatol (Hoboken, N.J.)"},{"key":"3168_CR23","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.3390\/nu11051180","volume":"11","author":"FC Liu","year":"2019","unstructured":"Liu FC, Wang CC, Lu JW, Lee CH, Chen SC, Ho YJ, Peng YJ (2019) Chondroprotective effects of genistein against osteoarthritis induced joint inflammation. Nutrients 11:1180. https:\/\/doi.org\/10.3390\/nu11051180","journal-title":"Nutrients"},{"key":"3168_CR24","doi-asserted-by":"publisher","first-page":"102663","DOI":"10.1016\/j.redox.2023.102663","volume":"62","author":"L Liu","year":"2023","unstructured":"Liu L, Zhang W, Liu T, Tan Y, Chen C, Zhao J, Geng H, Ma C (2023) The physiological metabolite \u03b1-ketoglutarate ameliorates osteoarthritis by regulating mitophagy and oxidative stress. Redox Biol 62:102663. https:\/\/doi.org\/10.1016\/j.redox.2023.102663","journal-title":"Redox Biol"},{"key":"3168_CR25","doi-asserted-by":"publisher","unstructured":"Lopez J, Al-Nakkash L, Broderick TL, Castro M, Tobin B, Plochocki JH (2023) Genistein suppresses IL-6 and MMP-13 to attenuate osteoarthritis in obese diabetic mice. Metabolites 13(9):1014. https:\/\/doi.org\/10.3390\/metabo13091014","DOI":"10.3390\/metabo13091014"},{"key":"3168_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1476-5381.2010.00661.x","volume":"160","author":"S Phukan","year":"2010","unstructured":"Phukan S, Babu VS, Kannoji A, Hariharan R, Balaji VN (2010) GSK3beta: role in therapeutic landscape and development of modulators. Bri J Pharmacol 160:1\u201319. https:\/\/doi.org\/10.1111\/j.1476-5381.2010.00661.x","journal-title":"Bri J Pharmacol"},{"key":"3168_CR27","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1136\/ard.61.2.161","volume":"61","author":"C Ribbens","year":"2002","unstructured":"Ribbens C, Martin Y, Porras M, Franchimont N, Kaiser MJ, Jaspar JM, Damas P, Houssiau FA, Malaise MG (2002) Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment. Annals Rheumat Diseases 61:161\u20136. https:\/\/doi.org\/10.1136\/ard.61.2.161","journal-title":"Annals Rheumat Diseases"},{"key":"3168_CR28","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s00402-017-2825-5","volume":"138","author":"SP Singer","year":"2018","unstructured":"Singer SP, Dammerer D, Krismer M, Liebensteiner MC (2018) Maximum lifetime body mass index is the appropriate predictor of knee and hip osteoarthritis. Arch Orthopaed Trauma Surge 138:99\u2013103. https:\/\/doi.org\/10.1007\/s00402-017-2825-5","journal-title":"Arch Orthopaed Trauma Surge"},{"key":"3168_CR29","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1186\/s12974-019-1660-8","volume":"16","author":"D Song","year":"2019","unstructured":"Song D, Zhang X, Chen J, Liu X, Xue J, Zhang L, Lan X (2019) Wnt canonical pathway activator TWS119 drives microglial anti-inflammatory activation and facilitates neurological recovery following experimental stroke. J Neuroinflamm 16:256. https:\/\/doi.org\/10.1186\/s12974-019-1660-8","journal-title":"J Neuroinflamm"},{"key":"3168_CR30","doi-asserted-by":"publisher","first-page":"1117893","DOI":"10.3389\/fphar.2023.1117893","volume":"14","author":"S Sudirman","year":"2023","unstructured":"Sudirman S, Chen CY, Chen CK, Felim J, Kuo HP, Kong ZL (2023) Fermented jellyfish (Rhopilema esculentum) collagen enhances antioxidant activity and cartilage protection on surgically induced osteoarthritis in obese rats. Front Pharmacol 14:1117893. https:\/\/doi.org\/10.3389\/fphar.2023.1117893","journal-title":"Front Pharmacol"},{"key":"3168_CR31","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/03008200902741463","volume":"50","author":"Z Tang","year":"2009","unstructured":"Tang Z, Yang L, Zhang J, Xue R, Wang Y, Chen PC, Sung KL (2009) Coordinated expression of MMPs and TIMPs in rat knee intra-articular tissues after ACL injury. Connect Tissue Res 50:315\u201322","journal-title":"Connect Tissue Res"},{"key":"3168_CR32","doi-asserted-by":"publisher","first-page":"7290","DOI":"10.3390\/ijms22147290","volume":"22","author":"ZH Wen","year":"2021","unstructured":"Wen ZH, Huang JS, Lin YY, Yao ZK, Lai YC, Chen WF, Liu HT, Lin SC, Tsai YC, Tsai TC, Jean YH (2021) Chondroprotective effects of a histone deacetylase inhibitor, panobinostat, on pain behavior and cartilage degradation in anterior cruciate ligament transection-induced experimental osteoarthritic rats. Int J Mol Sci 22:7290. https:\/\/doi.org\/10.3390\/ijms22147290","journal-title":"Int J Mol Sci"},{"key":"3168_CR33","doi-asserted-by":"publisher","first-page":"561459","DOI":"10.1155\/2014\/561459","volume":"2014","author":"P Wojdasiewicz","year":"2014","unstructured":"Wojdasiewicz P, Poniatowski \u0141A, Szukiewicz D (2014) The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis. Med Inflamm 2014:561459. https:\/\/doi.org\/10.1155\/2014\/561459","journal-title":"Med Inflamm"},{"key":"3168_CR34","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.tibs.2009.10.002","volume":"35","author":"D Wu","year":"2010","unstructured":"Wu D, Pan W (2010) GSK3: a multifaceted kinase in Wnt signaling. Trends Biochem Sci 35:161\u20138. https:\/\/doi.org\/10.1016\/j.tibs.2009.10.002","journal-title":"Trends Biochem Sci"},{"key":"3168_CR35","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1080\/03008207.2020.1778679","volume":"62","author":"K Xu","year":"2021","unstructured":"Xu K, Gao Y, Yang L, Liu Y, Wang C (2021) Magnolin exhibits anti-inflammatory effects on chondrocytes via the NF-\u03baB pathway for attenuating anterior cruciate ligament transection-induced osteoarthritis. Connect Tissue Res 62:475\u2013484. https:\/\/doi.org\/10.1080\/03008207.2020.1778679","journal-title":"Connect Tissue Res"},{"key":"3168_CR36","doi-asserted-by":"publisher","first-page":"436","DOI":"10.3390\/ijms17040436","volume":"17","author":"X Yang","year":"2016","unstructured":"Yang X, Guan Y, Tian S, Wang Y, Sun K, Chen Q (2016) Mechanical and IL-1\u03b2 responsive miR-365 contributes to osteoarthritis development by targeting histone deacetylase 4. Int J Mol Sci 17:436. https:\/\/doi.org\/10.3390\/ijms17040436","journal-title":"Int J Mol Sci"},{"key":"3168_CR37","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1139\/cjpp-2013-0228","volume":"92","author":"Z Ye","year":"2014","unstructured":"Ye Z, Chen Y, Zhang R, Dai H, Zeng C, Zeng H, Feng H, Du G, Fang H, Cai D (2014) c-Jun N-terminal kinase - c-Jun pathway transactivates Bim to promote osteoarthritis. Canadian J Physiol Pharmacol 92:132\u20139. https:\/\/doi.org\/10.1139\/cjpp-2013-0228","journal-title":"Canadian J Physiol Pharmacol"},{"key":"3168_CR38","doi-asserted-by":"publisher","first-page":"2629791","DOI":"10.1155\/2019\/2629791","volume":"2019","author":"J Yuan","year":"2019","unstructured":"Yuan J, Ding W, Wu N, Jiang S, Li W (2019) Protective effect of genistein on condylar cartilage through downregulating NF-\u03baB expression in experimentally created osteoarthritis rats. BioMed Res Int 2019:2629791. https:\/\/doi.org\/10.1155\/2019\/2629791","journal-title":"BioMed Res Int"},{"key":"3168_CR39","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/s0254-6272(10)60052-0","volume":"30","author":"PW Yuan","year":"2010","unstructured":"Yuan PW, Liu DY, Chu XD, Hao YQ, Zhu C, Qu Q (2010) Effects of preventive administration of Juanbi capsules on TNF-alpha, IL-1 and IL-6 contents of joint fluid in the rabbit with knee osteoarthritis. J Trad Chinese Med Chung i tsa chih ying wen pan 30:254\u20138. https:\/\/doi.org\/10.1016\/s0254-6272(10)60052-0","journal-title":"J Trad Chinese Med Chung i tsa chih ying wen pan"},{"key":"3168_CR40","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1007\/s00167-013-2425-z","volume":"22","author":"Y Zhang","year":"2014","unstructured":"Zhang Y, Huang W, Jiang J, Xie J, Xu C, Wang C, Yin L, Yang L, Zhou K, Chen P, Sung KP (2014) Influence of TNF-\u03b1 and biomechanical stress on matrix metalloproteinases and lysyl oxidases expressions in human knee synovial fibroblasts. Knee Surge Sports Traumatol Arthroscopy Off J ESSKA 22:1997\u20132006. https:\/\/doi.org\/10.1007\/s00167-013-2425-z","journal-title":"Knee Surge Sports Traumatol Arthroscopy Off J ESSKA"},{"key":"3168_CR41","doi-asserted-by":"publisher","first-page":"5258","DOI":"10.3892\/etm.2017.5264","volume":"14","author":"Y Zhang","year":"2017","unstructured":"Zhang Y, Jiang J, Xie J, Xu C, Wang C, Yin L, Yang L, Sung KP (2017) Combined effects of tumor necrosis factor-\u03b1 and interleukin-1\u03b2 on lysyl oxidase and matrix metalloproteinase expression in human knee synovial fibroblasts in vitro. Exp Therap Med 14:5258\u20135266. https:\/\/doi.org\/10.3892\/etm.2017.5264","journal-title":"Exp Therap Med"},{"key":"3168_CR42","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.ejphar.2016.07.027","volume":"789","author":"Y Zhou","year":"2016","unstructured":"Zhou Y, Tao H, Li Y, Deng M, He B, Xia S, Zhang C, Liu S (2016) Berberine promotes proliferation of sodium nitroprusside-stimulated rat chondrocytes and osteoarthritic rat cartilage via Wnt\/\u03b2-catenin pathway. Eur J Pharmacol 789:109\u2013118. https:\/\/doi.org\/10.1016\/j.ejphar.2016.07.027","journal-title":"Eur J Pharmacol"},{"key":"3168_CR43","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.3892\/mmr.2020.11254","volume":"22","author":"Y Zou","year":"2020","unstructured":"Zou Y, Liu Q, Guo P, Huang Y, Ye Z, Hu J (2020) Anti-chondrocyte apoptosis effect of genistein in treating inflammation-induced osteoarthritis. Mol Med Rep 22:2032\u20132042. https:\/\/doi.org\/10.3892\/mmr.2020.11254","journal-title":"Mol Med Rep"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03168-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-024-03168-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03168-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T09:08:24Z","timestamp":1727946504000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-024-03168-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,22]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["3168"],"URL":"https:\/\/doi.org\/10.1007\/s00210-024-03168-7","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,22]]},"assertion":[{"value":"30 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The animal experiments were approved by the Institutional Animal Care and Use Committee of Yantaishan Hospital (ethical approval number: 2024004). All protocols were carried out in accordance with the European Union regulations for the handling and use of laboratory animals and are reported following the ARRIVE guidelines for reporting experiments involving animals.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}