{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:59:52Z","timestamp":1793116792522,"version":"4.5.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s00210-024-03172-x","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T04:02:21Z","timestamp":1716782541000},"page":"7531-7549","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Silibinin as a major component of milk thistle seed provides promising influences against diabetes and its complications: a systematic review"],"prefix":"10.1007","volume":"397","author":[{"given":"Parisa","family":"Zare Mehrjerdi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Asadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Ehsani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid Reza","family":"Askari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vafa","family":"Baradaran Rahimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"3172_CR1","doi-asserted-by":"publisher","first-page":"105862","DOI":"10.1016\/j.jff.2023.105862","volume":"110","author":"I Akhlaghipour","year":"2023","unstructured":"Akhlaghipour I, Nasimi Shad A, Askari VR, Maharati A, Baradaran Rahimi V (2023) How caffeic acid and its derivatives combat diabetes and its complications: a systematic review. Journal of Functional Foods 110:105862","journal-title":"Journal of Functional Foods"},{"key":"3172_CR2","first-page":"7","volume":"2","author":"TA Aziz","year":"2014","unstructured":"Aziz TA, Marouf BH, Ahmed ZA, Hussain SA (2014) Anti-inflammatory activity of silibinin in animal models of chronic inflammation. Am J Pharmacol Sci 2:7\u201311","journal-title":"Am J Pharmacol Sci"},{"key":"3172_CR3","first-page":"220","volume":"44","author":"V Baradaran Rahimi","year":"2019","unstructured":"Baradaran Rahimi V, Askari VR, Hosseini M, Yousefsani BS, Sadeghnia HR (2019) Anticonvulsant activity of viola tricolor against seizures induced by pentylenetetrazol and maximal electroshock in mice. Iran J Med Sci 44:220\u2013226","journal-title":"Iran J Med Sci"},{"key":"3172_CR4","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1111\/1753-0407.12083","volume":"6","author":"S Bouderba","year":"2014","unstructured":"Bouderba S, Sanchez-Martin C, Villanueva GR, Detaille D, Koce\u00efr EA (2014) Beneficial effects of silibinin against the progression of metabolic syndrome, increased oxidative stress, and liver steatosis in Psammomys obesus, a relevant animal model of human obesity and diabetes. J Diabetes 6:184\u2013192","journal-title":"J Diabetes"},{"key":"3172_CR5","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1620\/tjem.2023.J050","volume":"261","author":"JL Cai","year":"2023","unstructured":"Cai JL, Zhu YL, Li XP, Deng GM, Han YS, Yuan FY, Yi GQ, Xia XH (2023) Liposomal Silybin improves glucose and lipid metabolisms in type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease via AMPK\/TGF-\u03b21\/Smad signaling. Tohoku J Exp Med 261:257\u2013265","journal-title":"Tohoku J Exp Med"},{"key":"3172_CR6","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.3892\/ijmm.2014.1883","volume":"34","author":"K Chen","year":"2014","unstructured":"Chen K, Zhao L, He H, Wan X, Wang F, Mo Z (2014) Silibinin protects \u03b2 cells from glucotoxicity through regulation of the Insig-1\/SREBP-1c pathway. Int J Mol Med 34:1073\u20131080","journal-title":"Int J Mol Med"},{"key":"3172_CR7","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.bbrc.2012.02.042","volume":"419","author":"BA Cheng","year":"2012","unstructured":"Cheng BA, Gong H, Li XC, Sun Y, Zhang X, Chen H, Liu XR, Zheng L, Huang K (2012) Silibinin inhibits the toxic aggregation of human islet amyloid polypeptide. Biochem Biophys Res Commun 419:495\u2013499","journal-title":"Biochem Biophys Res Commun"},{"key":"3172_CR8","doi-asserted-by":"publisher","first-page":"163","DOI":"10.4062\/biomolther.2019.071","volume":"28","author":"C Chu","year":"2020","unstructured":"Chu C, Gao X, Li X, Zhang XY, Ma RX, Jia Y, Li DH, Wang DK, Xu FX (2020) Involvement of estrogen receptor-alpha in the activation of Nrf2-antioxidative signaling pathways by silibinin in pancreatic beta-cells. Biomol Ther 28:163\u2013171","journal-title":"Biomol Ther"},{"key":"3172_CR9","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.cbi.2011.11.006","volume":"195","author":"CP Colturato","year":"2012","unstructured":"Colturato CP, Constantin RP, Maeda AS Jr, Constantin RP, Yamamoto NS, Bracht A, Ishii-Iwamoto EL, Constantin J (2012) Metabolic effects of silibinin in the rat liver. Chem Biol Interact 195:119\u2013132","journal-title":"Chem Biol Interact"},{"key":"3172_CR10","doi-asserted-by":"publisher","first-page":"e101818","DOI":"10.1371\/journal.pone.0101818","volume":"9","author":"S Das","year":"2014","unstructured":"Das S, Roy P, Pal R, Auddy RG, Chakraborti AS, Mukherjee A (2014) Engineered silybin nanoparticles educe efficient control in experimental diabetes. PLoS ONE 9:e101818","journal-title":"PLoS ONE"},{"key":"3172_CR11","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1002\/biof.1874","volume":"49","author":"M Dastani","year":"2023","unstructured":"Dastani M, Rahimi HR, Askari VR, Jaafari MR, Jarahi L, Yadollahi A, Rahimi VB (2023) Three months of combination therapy with nano-curcumin reduces the inflammation and lipoprotein (a) in type 2 diabetic patients with mild to moderate coronary artery disease: evidence of a randomized, double-blinded, placebo-controlled clinical trial. BioFactors 49:108\u2013118","journal-title":"BioFactors"},{"key":"3172_CR12","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.lfs.2008.03.007","volume":"82","author":"D Detaille","year":"2008","unstructured":"Detaille D, Sanchez C, Sanz N, Lopez-Novoa JM, Leverve X, El-Mir MY (2008) Interrelation between the inhibition of glycolytic flux by silibinin and the lowering of mitochondrial ROS production in perifused rat hepatocytes. Life Sci 82:1070\u20131076","journal-title":"Life Sci"},{"key":"3172_CR13","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1016\/S0891-5849(02)01043-2","volume":"33","author":"J Dietzmann","year":"2002","unstructured":"Dietzmann J, Thiel U, Ansorge S, Neumann KH, T\u00e4ger M (2002) Thiol-inducing and immunoregulatory effects of flavonoids in peripheral blood mononuclear cells from patients with end-stage diabetic nephropathy. Free Radic Biol Med 33:1347\u20131354","journal-title":"Free Radic Biol Med"},{"key":"3172_CR14","doi-asserted-by":"publisher","first-page":"109644","DOI":"10.1016\/j.abb.2023.109644","volume":"743","author":"Q Du","year":"2023","unstructured":"Du Q, Wu X, Ma K, Liu W, Liu P, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T (2023) Silibinin alleviates ferroptosis of rat islet \u03b2 cell INS-1 induced by the treatment with palmitic acid and high glucose through enhancing PINK1\/parkin-mediated mitophagy. Arch Biochem Biophys 743:109644","journal-title":"Arch Biochem Biophys"},{"key":"3172_CR15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.22159\/ijpps.2016v8i11.11692","volume":"8","author":"M El-Far","year":"2016","unstructured":"El-Far M, Negm AMR, El-Azim AA, Wahdan M (2016) Antioxidant therapeutic actions of medicinal phytochemicals, silymarin, and silibinin, on streptozotocin diabetic rats: first novel comparative assessment of structural recoveries of histological and ultrastructural changes on islets of langerhans, beta cells, mitochondria and nucleus. Int J Pharm Pharm Sci 8:69\u201376","journal-title":"Int J Pharm Pharm Sci"},{"key":"3172_CR16","doi-asserted-by":"publisher","first-page":"3863","DOI":"10.3390\/ijms21113863","volume":"21","author":"H Fujii","year":"2020","unstructured":"Fujii H, Kawada N, Nafld JSGO (2020) The role of insulin resistance and diabetes in nonalcoholic fatty liver disease. Int J Mol Sci 21:3863","journal-title":"Int J Mol Sci"},{"key":"3172_CR17","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1007\/s10787-021-00819-6","volume":"29","author":"M Ghadiri","year":"2021","unstructured":"Ghadiri M, Baradaran Rahimi V, Moradi E, Hasanpour M, Clark CCT, Iranshahi M, Rakhshandeh H, Askari VR (2021) Standardised pomegranate peel extract lavage prevents postoperative peritoneal adhesion by regulating TGF-\u03b2 and VEGF levels. Inflammopharmacology 29:855\u2013868","journal-title":"Inflammopharmacology"},{"key":"3172_CR18","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1007\/s10787-021-00865-0","volume":"29","author":"A Gholoobi","year":"2021","unstructured":"Gholoobi A, Askari VR, Naghedinia H, Ahmadi M, Vakili V, Baradaran Rahimi V (2021) Colchicine effectively attenuates inflammatory biomarker high-sensitivity C-reactive protein (hs-CRP) in patients with non-ST-segment elevation myocardial infarction: a randomised, double-blind, placebo-controlled clinical trial. Inflammopharmacology 29:1379\u20131387","journal-title":"Inflammopharmacology"},{"key":"3172_CR19","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1159\/000110453","volume":"20","author":"B Guigas","year":"2007","unstructured":"Guigas B, Naboulsi R, Villanueva GR, Taleux N, Lopez-Novoa JM, Leverve XM, El-Mir MY (2007) The flavonoid silibinin decreases glucose-6-phosphate hydrolysis in perifused rat hepatocytes by an inhibitory effect on glucose-6-phosphatase. Cell Physiol Biochem 20:925\u2013934","journal-title":"Cell Physiol Biochem"},{"key":"3172_CR20","first-page":"136","volume":"5","author":"D Jain","year":"2016","unstructured":"Jain D, Somani R, Gilhotra R (2016) Silibinin ameliorates hyperglycaemia, hyperlipidemia and prevent oxidative stress in streptozotocin induced diabetes in Sprague Dawley rats. Int J Pharm Res All Sci 5:136\u2013144","journal-title":"Int J Pharm Res All Sci"},{"key":"3172_CR21","doi-asserted-by":"publisher","first-page":"118","DOI":"10.4103\/0973-8258.155060","volume":"9","author":"D Jain","year":"2015","unstructured":"Jain D, Somani R (2015) Silibinin, a bioactive flavanone, prevents the progression of early diabetic nephropathy in experimental type-2 diabetic rats. Int J Green Pharm 9:118\u2013124","journal-title":"Int J Green Pharm"},{"key":"3172_CR22","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.abb.2018.09.024","volume":"659","author":"B Katebi","year":"2018","unstructured":"Katebi B, Mahdavimehr M, Meratan AA, Ghasemi A, Nemat-Gorgani M (2018) Protective effects of silibinin on insulin amyloid fibrillation, cytotoxicity and mitochondrial membrane damage. Arch Biochem Biophys 659:22\u201332","journal-title":"Arch Biochem Biophys"},{"key":"3172_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4614-5441-0_1","volume-title":"Diabetes: an old disease, a new insight","author":"K Kaul","year":"2013","unstructured":"Kaul K, Tarr JM, Ahmad SI, Kohner EM, Chibber R (2013) Introduction to diabetes mellitus. Diabetes: an old disease, a new insight, vol 771. pp 1\u201311"},{"key":"3172_CR24","doi-asserted-by":"publisher","first-page":"130364","DOI":"10.1016\/j.bbagen.2023.130364","volume":"1867","author":"A Khalid","year":"2023","unstructured":"Khalid A, Naseem I (2023) Increased therapeutic effect of nanotized silibinin against glycation and diabetes: An in vitro and in silico-based approach. Biochim Biophys Acta - General Subj 1867:130364","journal-title":"Biochim Biophys Acta - General Subj"},{"key":"3172_CR25","doi-asserted-by":"publisher","first-page":"F691","DOI":"10.1152\/ajprenal.00028.2013","volume":"305","author":"K Khazim","year":"2013","unstructured":"Khazim K, Gorin Y, Cavaglieri RC, Abboud HE, Fanti P (2013) The antioxidant silybin prevents high glucose-induced oxidative stress and podocyte injury in vitro and in vivo. Am J Physiol - Renal Physiol 305:F691\u2013F700","journal-title":"Am J Physiol - Renal Physiol"},{"key":"3172_CR26","doi-asserted-by":"publisher","first-page":"15","DOI":"10.4093\/dmj.2021.0280","volume":"46","author":"S-H Lee","year":"2022","unstructured":"Lee S-H, Park S-Y, Choi CS (2022) Insulin resistance: from mechanisms to therapeutic strategies. Diabetes Metab J 46:15\u201337","journal-title":"Diabetes Metab J"},{"key":"3172_CR27","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1590\/1414-431x20144238","volume":"48","author":"H Li","year":"2015","unstructured":"Li H, Yang Y, Mo Z, Ding Y, Jiang W (2015) Silibinin improves palmitate-induced insulin resistance in C2C12 myotubes by attenuating IRS-1\/PI3K\/Akt pathway inhibition. Braz J Med Biol Res 48:440\u2013446","journal-title":"Braz J Med Biol Res"},{"key":"3172_CR28","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/1475-2840-10-62","volume":"14","author":"G Li Volti","year":"2011","unstructured":"Li Volti G, Salomone S, Sorrenti V, Mangiameli A, Urso V, Siarkos I, Galvano F, Salamone F (2011) Effect of silibinin on endothelial dysfunction and ADMA levels in obese diabetic mice. Cardiovasc Diabetol 14:62","journal-title":"Cardiovasc Diabetol"},{"key":"3172_CR29","first-page":"222","volume":"15","author":"F Lirussi","year":"2002","unstructured":"Lirussi F, Beccarello A, Zanette G, De Monte A, Donadon V, Velussi M, Crepaldi G (2002) Silybin-beta-cyclodextrin in the treatment of patients with diabetes mellitus and alcoholic liver disease. Efficacy study of a new preparation of an anti-oxidant agent. Diabetes Nutr Metab 15:222\u2013231","journal-title":"Diabetes Nutr Metab"},{"key":"3172_CR30","doi-asserted-by":"publisher","first-page":"3117","DOI":"10.2147\/DDDT.S209981","volume":"13","author":"K Liu","year":"2019","unstructured":"Liu K, Zhou S, Liu J, Wang Y, Zhu F, Liu M (2019a) Silibinin attenuates high-fat diet-induced renal fibrosis of diabetic nephropathy. Drug Des Dev Ther 13:3117\u20133126","journal-title":"Drug Des Dev Ther"},{"key":"3172_CR31","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.ejphar.2018.12.031","volume":"845","author":"Y Liu","year":"2019","unstructured":"Liu Y, Ye J, Cao Y, Zhang R, Wang Y, Zhang S, Dai W, Ye S (2019b) Silibinin ameliorates diabetic nephropathy via improving diabetic condition in the mice. Eur J Pharmacol 845:24\u201331","journal-title":"Eur J Pharmacol"},{"key":"3172_CR32","doi-asserted-by":"publisher","first-page":"112689","DOI":"10.1016\/j.physbeh.2019.112689","volume":"213","author":"PW Liu","year":"2020","unstructured":"Liu PW, Cui LY, Liu B, Liu WW, Hayashi T, Mizuno K, Hattori S, Ushiki-Kaku Y, Onodera S, Ikejima T (2020) Silibinin ameliorates STZ-induced impairment of memory and learning by up- regulating insulin signaling pathway and attenuating apoptosis. Physiol Behav 213:112689","journal-title":"Physiol Behav"},{"key":"3172_CR33","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/s41419-018-0718-3","volume":"9","author":"YX Mao","year":"2018","unstructured":"Mao YX, Cai WJ, Sun XY, Dai PP, Li XM, Wang Q, Huang XL, He B, Wang PP, Wu G, Ma JF, Huang SB (2018) RAGE-dependent mitochondria pathway: a novel target of silibinin against apoptosis of osteoblastic cells induced by advanced glycation end products article. Cell Death Dis 9:674","journal-title":"Cell Death Dis"},{"key":"3172_CR34","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.neulet.2011.09.041","volume":"504","author":"G Marrazzo","year":"2011","unstructured":"Marrazzo G, Bosco P, La Delia F, Scapagnini G, Di Giacomo C, Malaguarnera M, Galvano F, Nicolosi A, Volti GL (2011) Neuroprotective effect of silibinin in diabetic mice. Neurosci Lett 504:252\u2013256","journal-title":"Neurosci Lett"},{"key":"3172_CR35","first-page":"1235","volume":"22","author":"A Mirzaei","year":"2023","unstructured":"Mirzaei A, Mirzaei A, Najjar Khalilabad S, Askari VR, Baradaran Rahimi V (2023) Promising influences of hesperidin and hesperetin against diabetes and its complications: a systematic review of molecular, cellular, and metabolic effects. EXCLI J 22:1235\u20131263","journal-title":"EXCLI J"},{"key":"3172_CR36","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1007\/s40200-020-00637-7","volume":"19","author":"H Mohammadi","year":"2020","unstructured":"Mohammadi H, Manouchehri H, Changizi R, Bootorabi F, Khorramizadeh MR (2020) Concurrent metformin and silibinin therapy in diabetes: assessments in zebrafish (Danio rerio) animal model. J Diabetes Metab Disord 19:1233\u20131244","journal-title":"J Diabetes Metab Disord"},{"key":"3172_CR37","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.saa.2018.10.044","volume":"209","author":"K Neelofar","year":"2019","unstructured":"Neelofar K, Arif Z, Ahmad J, Alam K (2019) Inhibitory effect of silibinin on Amadori-albumin in diabetes mellitus: a multi-spectroscopic and biochemical approach. Spectrochim Acta - Part a: Mol Biomol Spectrosc 209:217\u2013222","journal-title":"Spectrochim Acta - Part a: Mol Biomol Spectrosc"},{"key":"3172_CR38","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.amjmed.2003.10.016","volume":"116","author":"RW Nesto","year":"2004","unstructured":"Nesto RW (2004) Correlation between cardiovascular disease and diabetes mellitus: current concepts. Am J Med 116:11\u201322","journal-title":"Am J Med"},{"key":"3172_CR39","doi-asserted-by":"crossref","unstructured":"Ong KL, Stafford LK, McLaughlin SA, Boyko EJ, Vollset SE, Smith AE, Dalton BE, Duprey J, Cruz JA, Hagins H (2023) Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021. Lancet 402:203\u2013234","DOI":"10.1016\/S0140-6736(23)01301-6"},{"key":"3172_CR40","first-page":"97","volume":"83","author":"OM Palomino","year":"2017","unstructured":"Palomino OM, Gouveia NM, Ramos S, Mart\u00edn MA, Goya L (2017) Protective effect of silybum marianum and silibinin on endothelial cells submitted to high glucose concentration. Planta Med 83:97\u2013103","journal-title":"Planta Med"},{"key":"3172_CR41","doi-asserted-by":"crossref","unstructured":"Rakelly de Oliveira D, Relison Tintino S, Morais Braga MFB, Boligon AA, Linde Athayde M, Douglas Melo Coutinho H, de Menezes IRA, Fachinetto R (2015) In vitro antimicrobial and modulatory activity of the natural products silymarin and silibinin. BioMed Res Int 2015:292797","DOI":"10.1155\/2015\/292797"},{"key":"3172_CR42","doi-asserted-by":"publisher","first-page":"8084","DOI":"10.1002\/jcb.26735","volume":"119","author":"A Rezabakhsh","year":"2018","unstructured":"Rezabakhsh A, Fathi F, Bagheri HS, Malekinejad H, Montaseri A, Rahbarghazi R, Garjani A (2018) Silibinin protects human endothelial cells from high glucose-induced injury by enhancing autophagic response. J Cell Biochem 119:8084\u20138094","journal-title":"J Cell Biochem"},{"key":"3172_CR43","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1055\/a-1118-3918","volume":"86","author":"Y Roohbakhsh","year":"2020","unstructured":"Roohbakhsh Y, Baradaran Rahimi V, Silakhori S, Rajabi H, Rahmanian-Devin P, Samzadeh-Kermani A, Rakhshandeh H, Hasanpour M, Iranshahi M, Mousavi SH, Askari VR (2020) Evaluation of the effects of peritoneal lavage with Rosmarinus officinalis extract against the prevention of postsurgical-induced peritoneal adhesion. Planta Med 86:405\u2013414","journal-title":"Planta Med"},{"key":"3172_CR44","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1016\/S0891-5849(00)00224-0","volume":"28","author":"RE Shackelford","year":"2000","unstructured":"Shackelford RE, Kaufmann WK, Paules RS (2000) Oxidative stress and cell cycle checkpoint function. Free Radical Biol Med 28:1387\u20131404","journal-title":"Free Radical Biol Med"},{"key":"3172_CR45","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1080\/19476337.2023.2222787","volume":"21","author":"XY Shi","year":"2023","unstructured":"Shi XY, Chu C, Li X, Zhang LX, Zhang XR, Chen N, Liu WW, Jiao ZX, Ikejima T, Xu FX (2023) Silibinin protects GLUTag cells from PA-induced injury via suppressing endoplasmic reticulum stress. Cyta-Journal of Food 21:442\u2013450","journal-title":"Cyta-Journal of Food"},{"key":"3172_CR46","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s11010-019-03572-1","volume":"460","author":"Y Sun","year":"2019","unstructured":"Sun Y, Yang J, Liu WW, Yao GD, Xu FX, Hayashi T, Onodera S, Ikejima T (2019) Attenuating effect of silibinin on palmitic acid-induced apoptosis and mitochondrial dysfunction in pancreatic beta-cells is mediated by estrogen receptor alpha. Mol Cell Biochem 460:81\u201392","journal-title":"Mol Cell Biochem"},{"key":"3172_CR47","doi-asserted-by":"crossref","unstructured":"Tao ZS, Wang HS, Li TL, Wei S (2022) Silibinin-modified Hydroxyapatite coating promotes the osseointegration of titanium rods by activation SIRT1\/SOD2 signaling pathway in diabetic rats. J Mater Sci: Mater Med 33(9):62","DOI":"10.1007\/s10856-022-06684-1"},{"key":"3172_CR48","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.mrgentox.2017.11.002","volume":"825","author":"VA To\u011fay","year":"2018","unstructured":"To\u011fay VA, Sevimli TS, Sevimli M, \u00c7elik DA, \u00d6z\u00e7elik N (2018) DNA damage in rats with streptozotocin-induced diabetes; protective effect of silibinin. Mutat Res \u2013 Genet Toxicol Environ Mutagen 825:15\u201318","journal-title":"Mutat Res \u2013 Genet Toxicol Environ Mutagen"},{"key":"3172_CR49","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1007\/s000180050111","volume":"53","author":"J von Sch\u00f6nfeld","year":"1997","unstructured":"von Sch\u00f6nfeld J, Weisbrod B, M\u00fcller MK (1997) Silibinin, a plant extract with antioxidant and membrane stabilizing properties, protects exocrine pancreas from cyclosporin A toxicity. Cell Mol Life Sci 53:917\u2013920","journal-title":"Cell Mol Life Sci"},{"key":"3172_CR50","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1080\/10286020.2012.657180","volume":"14","author":"Q Wang","year":"2012","unstructured":"Wang Q, Liu M, Liu WW, Hao WB, Tashiro S, Onodera S, Ikejima T (2012) In vivo recovery effect of silibinin treatment on streptozotocin-induced diabetic mice is associated with the modulations of sirt-1 expression and autophagy in pancreatic beta-cell. J Asian Nat Prod Res 14:413\u2013423","journal-title":"J Asian Nat Prod Res"},{"key":"3172_CR51","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.biopha.2017.02.018","volume":"89","author":"T Wang","year":"2017","unstructured":"Wang T, Cai L, Wang Y, Wang Q, Lu D, Chen H, Ying X (2017) The protective effects of silibinin in the treatment of streptozotocin-induced diabetic osteoporosis in rats. Biomed Pharmacother 89:681\u2013688","journal-title":"Biomed Pharmacother"},{"key":"3172_CR52","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1515\/tjb-2021-0010","volume":"47","author":"H Wang","year":"2022","unstructured":"Wang H, Zhu J, Jia Z, Lu S (2022a) Pretreatment of diabetic aged rats with combination of ginsenoside-Mc1 and silibinin protects liver from ischemia-reperfusion injury through an AMPK-dependent mechanism. Turkish J Biochem 47:23\u201332","journal-title":"Turkish J Biochem"},{"key":"3172_CR53","doi-asserted-by":"crossref","unstructured":"Wang J, Zhang L, Cao H, Shi X, Zhang X, Gao Z, Ikeda K, Yan T, Jia Y, Xu F (2022b) Silibinin improves L-cell mass and function through an estrogen receptor-mediated antioxidative mechanism. Phytomed 99:154022","DOI":"10.1016\/j.phymed.2022.154022"},{"key":"3172_CR54","doi-asserted-by":"publisher","first-page":"186","DOI":"10.2174\/1871520611009030186","volume":"10","author":"C Wing Ying Cheung","year":"2010","unstructured":"Wing Ying Cheung C, Gibbons N, Wayne Johnson D, Lawrence Nicol D (2010) Silibinin-a promising new treatment for cancer. Anti-Cancer Agents Med Chem (Form Curr Med Chem-Anti-Cancer Agents) 10:186\u2013195","journal-title":"Anti-Cancer Agents Med Chem (Form Curr Med Chem-Anti-Cancer Agents)"},{"key":"3172_CR55","doi-asserted-by":"publisher","first-page":"4926","DOI":"10.1039\/C8FO00565F","volume":"9","author":"F Xu","year":"2018","unstructured":"Xu F, Yang J, Negishi H, Sun Y, Li D, Zhang X, Hayashi T, Gao M, Ikeda K, Ikejima T (2018) Silibinin decreases hepatic glucose production through the activation of gut-brain-liver axis in diabetic rats. Food Funct 9:4926\u20134935","journal-title":"Food Funct"},{"key":"3172_CR56","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.biopha.2018.01.128","volume":"102","author":"J Yang","year":"2018","unstructured":"Yang J, Sun Y, Xu FX, Liu WW, Hayashi T, Onodera S, Tashiro S, Ikejima T (2018) Involvement of estrogen receptors in silibinin protection of pancreatic beta-cells from TNF alpha- or IL-1 beta-induced cytotoxicity. Biomed Pharmacother 102:344\u2013353","journal-title":"Biomed Pharmacother"},{"key":"3172_CR57","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1080\/03008207.2019.1593393","volume":"60","author":"J Yang","year":"2019","unstructured":"Yang J, Sun Y, Liu XL, Xu FX, Liu WW, Hayashi T, Imamura Y, Mizuno K, Hattori S, Tanaka K, Fujisaki H, Tashiro SI, Onodera S, Ikejima T (2019) Silibinin\u2019s regulation of proliferation and collagen gene expressions of rat pancreatic beta-cells cultured on types I and V collagen involves beta-catenin nuclear translocation. Connect Tissue Res 60:463\u2013476","journal-title":"Connect Tissue Res"},{"key":"3172_CR58","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.ejphar.2015.09.005","volume":"765","author":"XZ Ying","year":"2015","unstructured":"Ying XZ, Chen XW, Liu HX, Nie PF, Shui XL, Shen Y, Yu KH, Cheng SW (2015) Silibinin alleviates high glucose-suppressed osteogenic differentiation of human bone marrow stromal cells via antioxidant effect and PI3K\/Akt signaling. Eur J Pharmacol 765:394\u2013401","journal-title":"Eur J Pharmacol"},{"key":"3172_CR59","doi-asserted-by":"publisher","first-page":"172805","DOI":"10.1016\/j.ejphar.2019.172805","volume":"866","author":"X Ying","year":"2020","unstructured":"Ying X, Chen X, Wang T, Zheng W, Chen L, Xu Y (2020) Possible osteoprotective effects of myricetin in STZ induced diabetic osteoporosis in rats. Eur J Pharmacol 866:172805","journal-title":"Eur J Pharmacol"},{"key":"3172_CR60","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1002\/jcb.22984","volume":"112","author":"T Zhan","year":"2011","unstructured":"Zhan T, Digel M, K\u00fcch EM, Stremmel W, F\u00fcllekrug J (2011) Silybin and dehydrosilybin decrease glucose uptake by inhibiting GLUT proteins. J Cell Biochem 112:849\u2013859","journal-title":"J Cell Biochem"},{"key":"3172_CR61","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1007\/BF02942753","volume":"1","author":"JQ Zhang","year":"1995","unstructured":"Zhang JQ, Xm Mao, Zhou YP (1995) Silybin decreases erythrocytic sorbitol level and improves peripheral nerve conduction velocity in patients with non-insulin dependent diabetes mellitus. Chin J Integr Tradition West Med 1:84\u201386","journal-title":"Chin J Integr Tradition West Med"},{"key":"3172_CR62","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.ejphar.2014.07.033","volume":"740","author":"HT Zhang","year":"2014","unstructured":"Zhang HT, Shi K, Baskota A, Zhou FL, Chen YX, Tian HM (2014) Silybin reduces obliterated retinal capillaries in experimental diabetic retinopathy in rats. Eur J Pharmacol 740:233\u2013239","journal-title":"Eur J Pharmacol"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03172-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-024-03172-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03172-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T09:09:26Z","timestamp":1727946566000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-024-03172-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,27]]},"references-count":62,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["3172"],"URL":"https:\/\/doi.org\/10.1007\/s00210-024-03172-x","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,27]]},"assertion":[{"value":"9 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This is a review article. Ethical approval is not required for the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}