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The exosome-mediated transmittance of drug resistance has been shown in various cancer models including ovarian and prostate cancer models. In this study, we aimed to investigate the role of exosomal miRNA transfer in\u00a0chronic myeloid leukemia drug resistance. For this purpose, firstly exosomes were isolated from imatinib sensitive (K562S) and resistant (K562R) chronic myeloid leukemia (CML)\u00a0cells and named as Sexo and Rexo, respectively. Then, miRNA microarray was used to compare miRNA profiles of K562S, K562R, Sexo, Rexo, and Rexo-treated K562S cells. According to our results, miR-125b-5p and miR-99a-5p exhibited increased expression in resistant cells, their exosomes, and Rexo-treated sensitive cells compared to their sensitive counterparts. On the other hand, miR-210-3p and miR-193b-3p were determined to be the two miRNAs which exhibited decreased expression profile in resistant cells and their exosomes compared to their sensitive counterparts. Gene targets, signaling pathways, and enrichment analysis were performed for these miRNAs by TargetScan, KEGG, and DAVID. Potential interactions between gene candidates at the protein level were analyzed via STRING and Cytoscape software. Our findings revealed <jats:italic>CCR5<\/jats:italic>, <jats:italic>GRK2<\/jats:italic>, <jats:italic>EDN1<\/jats:italic>, <jats:italic>ARRB1<\/jats:italic>, <jats:italic>P2RY2<\/jats:italic>, <jats:italic>LAMC2<\/jats:italic>, <jats:italic>PAK3<\/jats:italic>, <jats:italic>PAK4<\/jats:italic>, and <jats:italic>GIT2<\/jats:italic> as novel gene targets that may play roles in exosomal imatinib resistance transfer as well as <jats:italic>mTOR<\/jats:italic>, <jats:italic>STAT3<\/jats:italic>, <jats:italic>MCL1<\/jats:italic>, <jats:italic>LAMC1<\/jats:italic>, and <jats:italic>KRAS<\/jats:italic> which are already linked to imatinib resistance. <jats:italic>MDR1<\/jats:italic> mRNA exhibited higher expression in Rexo compared to Sexo as well as in K562S cells treated with Rexo compared to K562S cells which may suggest exosomal transfer of <jats:italic>MDR1<\/jats:italic> mRNA.<\/jats:p>\n                <jats:p><jats:bold>Graphical Abstract<\/jats:bold><\/jats:p>","DOI":"10.1007\/s00210-024-03198-1","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T14:02:08Z","timestamp":1719324128000},"page":"9701-9721","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Identification of exosomal microRNAs and related hub genes associated with imatinib resistance in chronic myeloid leukemia"],"prefix":"10.1007","volume":"397","author":[{"given":"Arzu Zeynep","family":"Karabay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tulin","family":"Ozkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aynur","family":"Karadag Gurel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asli","family":"Koc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalda","family":"Hekmatshoar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuman","family":"Sunguroglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fugen","family":"Aktan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeliha","family":"Buyukbing\u00f6l","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"issue":"11","key":"3198_CR1","doi-asserted-by":"publisher","first-page":"9175","DOI":"10.3390\/ijms24119175","volume":"24","author":"J Abramczyk","year":"2023","unstructured":"Abramczyk J, Milkiewicz M, Hula B, Milkiewicz P, Kempinska-Podhorodecka A (2023) The role of hsamiR-125b-5p interaction with S1P\/Ceramide Axis in the potential development of inflammation-associated coloncancer in primary sclerosing cholangitis. 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