{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T13:07:52Z","timestamp":1778504872306,"version":"3.51.4"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s00210-024-03242-0","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T03:02:53Z","timestamp":1719370973000},"page":"9845-9858","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The potential liver injury induced by metronidazole-provoked disturbance of gut microbiota: modulatory effect of turmeric supplementation"],"prefix":"10.1007","volume":"397","author":[{"given":"Abdulaziz Qaid","family":"Ali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deema Kamal","family":"Sabir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal F.","family":"Dawood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Abu-Rashed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulrahman","family":"Hasari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faiz","family":"Gharqan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salem","family":"Alnefaie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lama E.","family":"Mohiddin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya M.","family":"Tatry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana A.","family":"Albadan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohanad M.","family":"Alyami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed F.","family":"Almutairi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lamiaa M.","family":"Shawky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"key":"3242_CR1","doi-asserted-by":"publisher","first-page":"303","DOI":"10.3390\/toxics11040303","volume":"11","author":"MA AbdRabou","year":"2023","unstructured":"AbdRabou MA, Alrashdi BM, Alruwaili HK, Elmazoudy RH, Alwaili MA, Othman SI, Alghamdi FA, Fahmy GH (2023) Exploration of maternal and fetal toxicity risks for metronidazole-related teratogenicity and hepatotoxicity through an assessment in Albino rats. Toxics 11:303","journal-title":"Toxics"},{"key":"3242_CR2","doi-asserted-by":"publisher","first-page":"e22483","DOI":"10.1002\/jbt.22483","volume":"34","author":"K Abubakar","year":"2020","unstructured":"Abubakar K, Mailafiya MM, Chiroma SM, Danmaigoro A, Zyoud TYT, Abdul Rahim E, Abu Bakar Zakaria MZ (2020) Ameliorative effect of curcumin on lead-induced hematological and hepatorenal toxicity in a rat model. J Biochem Mol Toxicol 34:e22483","journal-title":"J Biochem Mol Toxicol"},{"key":"3242_CR3","doi-asserted-by":"publisher","unstructured":"Akaberi M, Sahebkar A, Emami SA (2021) Turmeric and curcumin: from traditional to modern medicine BT - studies on biomarkers and new targets in aging research in Iran: focus on turmeric and curcumin. In: Guest PC (ed). Springer International Publishing, Cham, pp 15\u201339. https:\/\/doi.org\/10.1007\/978-3-030-56153-6_2","DOI":"10.1007\/978-3-030-56153-6_2"},{"key":"3242_CR4","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s12072-018-9882-x","volume":"12","author":"M Atif","year":"2018","unstructured":"Atif M, Warner S, Oo YH (2018) Linking the gut and liver: crosstalk between regulatory T cells and mucosa-associated invariant T cells. Hepatol Int 12:305\u2013314","journal-title":"Hepatol Int"},{"key":"3242_CR5","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1177\/09564624231179505","volume":"34","author":"O Ayinde","year":"2023","unstructured":"Ayinde O, Ross JDC (2023) The frequency and duration of side-effects associated with the use of oral metronidazole; a prospective study of VITA trial participants. Int J STD AIDS 34:897\u2013902. https:\/\/doi.org\/10.1177\/09564624231179505","journal-title":"Int J STD AIDS"},{"key":"3242_CR6","doi-asserted-by":"crossref","unstructured":"Bancroft JD, Lyton C (2019) The Hematoxylins and Eosin. In: Suvarna SK, Bancroft JD, Lyton C (eighth eds) Bancroft\u2019s theory and practice of histological techniques. Elsevier health sciences, pp 126\u2013138","DOI":"10.1016\/B978-0-7020-6864-5.00010-4"},{"key":"3242_CR7","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.ccell.2021.03.004","volume":"39","author":"A Bertocchi","year":"2021","unstructured":"Bertocchi A, Carloni S, Ravenda PS, Bertalot G, Spadoni I, Cascio AL, Gandini S, Lizier M, Braga D, Asnicar F (2021) Gut vascular barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver. Cancer Cell 39:708\u2013724","journal-title":"Cancer Cell"},{"key":"3242_CR8","doi-asserted-by":"publisher","unstructured":"Bokoliya SC, Dorsett Y, Panier H, Zhou Y (2021) Procedures for fecal microbiota transplantation in murine microbiome studies. Front Cell Infect Microbiol 11:711055. https:\/\/doi.org\/10.3389\/fcimb.2021.711055","DOI":"10.3389\/fcimb.2021.711055"},{"key":"3242_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuro.2020.03.002","volume":"79","author":"S Chaturvedi","year":"2020","unstructured":"Chaturvedi S, Malik MY, Rashid M, Singh S, Tiwari V, Gupta P, Shukla S, Singh S, Wahajuddin M (2020) Mechanistic exploration of quercetin against metronidazole induced neurotoxicity in rats: possible role of nitric oxide isoforms and inflammatory cytokines. Neurotoxicology 79:1\u201310. https:\/\/doi.org\/10.1016\/j.neuro.2020.03.002","journal-title":"Neurotoxicology"},{"key":"3242_CR10","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1093\/jac\/dkx351","volume":"73","author":"SA Dingsdag","year":"2018","unstructured":"Dingsdag SA, Hunter N (2018) Metronidazole: an update on metabolism, structure\u2013cytotoxicity and resistance mechanisms. J Antimicrob Chemother 73:265\u2013279. https:\/\/doi.org\/10.1093\/jac\/dkx351","journal-title":"J Antimicrob Chemother"},{"key":"3242_CR11","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3390\/ani12020145","volume":"12","author":"M Giery\u0144ska","year":"2022","unstructured":"Giery\u0144ska M, Szulc-D\u0105browska L, Struzik J, Mielcarska MB, Gregorczyk-Zboroch KP (2022) Integrity of the intestinal barrier: the involvement of epithelial cells and microbiota\u2014a mutual relationship. Animals 12:145","journal-title":"Animals"},{"key":"3242_CR12","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1093\/jac\/dky471","volume":"74","author":"BW Haak","year":"2019","unstructured":"Haak BW, Lankelma JM, Hugenholtz F, Belzer C, de Vos WM, Wiersinga WJ (2019) Long-term impact of oral vancomycin, ciprofloxacin and metronidazole on the gut microbiota in healthy humans. J Antimicrob Chemother 74:782\u2013786","journal-title":"J Antimicrob Chemother"},{"key":"3242_CR13","doi-asserted-by":"publisher","first-page":"e7502","DOI":"10.7717\/peerj.7502","volume":"7","author":"N Hasan","year":"2019","unstructured":"Hasan N, Yang H (2019) Factors affecting the composition of the gut microbiota, and its modulation. PeerJ 7:e7502. https:\/\/doi.org\/10.7717\/peerj.7502","journal-title":"PeerJ"},{"key":"3242_CR14","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1080\/13880209.2017.1345951","volume":"55","author":"MS Hossen","year":"2017","unstructured":"Hossen MS, Tanvir EM, Prince MB, Paul S, Saha M, Ali MY, Gan SH, Khalil MI, Karim N (2017) Protective mechanism of turmeric (Curcuma longa) on carbofuran-induced hematological and hepatic toxicities in a rat model. Pharm Biol 55:1937\u20131945","journal-title":"Pharm Biol"},{"key":"3242_CR15","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1016\/j.jhep.2021.08.003","volume":"75","author":"CL Hsu","year":"2021","unstructured":"Hsu CL, Duan Y, Fouts DE, Schnabl B (2021) Intestinal virome and therapeutic potential of bacteriophages in liver disease. J Hepatol 75:1465\u20131475","journal-title":"J Hepatol"},{"key":"3242_CR16","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1080\/16583655.2020.1790928","volume":"14","author":"J Ibrahim","year":"2020","unstructured":"Ibrahim J, Kabiru AY, Abdulrasheed-Adeleke T, Lawal B, Adewuyi AH (2020) Antioxidant and hepatoprotective potentials of curcuminoid isolates from turmeric (Curcuma longa) rhizome on CCl4-induced hepatic damage in Wistar rats. J Taibah Univ Sci 14:908\u2013915","journal-title":"J Taibah Univ Sci"},{"key":"3242_CR17","doi-asserted-by":"publisher","first-page":"66313","DOI":"10.1007\/s11356-021-15695-4","volume":"28","author":"A Ishaq","year":"2021","unstructured":"Ishaq A, Gulzar H, Hassan A, Kamran M, Riaz M, Parveen A, Chattha MS, Walayat N, Fatima S, Afzal S (2021) Ameliorative mechanisms of turmeric-extracted curcumin on arsenic (As)-induced biochemical alterations, oxidative damage, and impaired organ functions in rats. Environ Sci Pollut Res 28:66313\u201366326","journal-title":"Environ Sci Pollut Res"},{"key":"3242_CR18","unstructured":"Kiernan JA (2015) Immunohistochemistry. In: Kiernan J (fifth ed) Histological and histochemical methods. Theory and practice. Scion Publishing Limited, UK,\u00a0pp 454\u2013490. www.scionpublishing.com"},{"key":"3242_CR19","doi-asserted-by":"publisher","first-page":"3289","DOI":"10.3389\/fmicb.2018.03289","volume":"9","author":"T Le Roy","year":"2019","unstructured":"Le Roy T, Deb\u00e9dat J, Marquet F, Da-Cunha C, Ichou F, Guerre-Millo M, Kapel N, Aron-Wisnewsky J, Cl\u00e9ment K (2019) Comparative evaluation of microbiota engraftment following fecal microbiota transfer in mice models: age, kinetic and microbial status matter. Front Microbiol 9:3289","journal-title":"Front Microbiol"},{"key":"3242_CR20","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1186\/s12906-015-0773-6","volume":"15","author":"AR Moghadam","year":"2015","unstructured":"Moghadam AR, Tutunchi S, Namvaran-Abbas-Abad A, Yazdi M, Bonyadi F, Mohajeri D, Mazani M, Marzban H, \u0141os MJ, Ghavami S (2015) Pre-administration of turmeric prevents methotrexate-induced liver toxicity and oxidative stress. BMC Complement Altern Med 15:246. https:\/\/doi.org\/10.1186\/s12906-015-0773-6","journal-title":"BMC Complement Altern Med"},{"key":"3242_CR21","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1159\/000479918","volume":"71","author":"R Nagpal","year":"2017","unstructured":"Nagpal R, Yadav H (2017) Bacterial translocation from the gut to the distant organs: an overview. Ann Nutr Metab 71:11\u201316","journal-title":"Ann Nutr Metab"},{"key":"3242_CR22","doi-asserted-by":"publisher","DOI":"10.17226\/12910","volume-title":"Guide for the care and use of laboratory animals","author":"NIH","year":"2011","unstructured":"NIH (2011) Guide for the care and use of laboratory animals, 8th edn. National Academies Press US, New York. https:\/\/doi.org\/10.17226\/12910","edition":"8"},{"key":"3242_CR23","doi-asserted-by":"publisher","first-page":"303","DOI":"10.5829\/idosi.gv.2012.9.3.65175","volume":"9","author":"SS Oda","year":"2012","unstructured":"Oda SS (2012) Histopathological and biochemical alterations of metronidazole-induced toxicity in male rats. Glob Vet 9:303\u2013310. https:\/\/doi.org\/10.5829\/idosi.gv.2012.9.3.65175","journal-title":"Glob Vet"},{"key":"3242_CR24","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1111\/jvim.15871","volume":"34","author":"R Pilla","year":"2020","unstructured":"Pilla R, Gaschen FP, Barr JW, Olson E, Honneffer J, Guard BC, Blake AB, Villanueva D, Khattab MR, AlShawaqfeh MK (2020) Effects of metronidazole on the fecal microbiome and metabolome in healthy dogs. J Vet Intern Med 34:1853\u20131866. https:\/\/doi.org\/10.1111\/jvim.15871","journal-title":"J Vet Intern Med"},{"key":"3242_CR25","doi-asserted-by":"publisher","first-page":"S67","DOI":"10.1016\/j.jhep.2020.11.013","volume":"75","author":"J Trebicka","year":"2021","unstructured":"Trebicka J, Macnaughtan J, Schnabl B, Shawcross DL, Bajaj JS (2021) The microbiota in cirrhosis and its role in hepatic decompensation. J Hepatol 75:S67\u2013S81","journal-title":"J Hepatol"},{"key":"3242_CR26","doi-asserted-by":"publisher","first-page":"e0144854","DOI":"10.1371\/journal.pone.0144854","volume":"10","author":"MV-L Tulstrup","year":"2015","unstructured":"Tulstrup MV-L, Christensen EG, Carvalho V, Linninge C, Ahrn\u00e9 S, H\u00f8jberg O, Licht TR, Bahl MI (2015) Antibiotic treatment affects intestinal permeability and gut microbial composition in Wistar rats dependent on antibiotic class. PLoS ONE 10:e0144854. https:\/\/doi.org\/10.1371\/journal.pone.0144854","journal-title":"PLoS ONE"},{"key":"3242_CR27","doi-asserted-by":"publisher","first-page":"874878","DOI":"10.3389\/fimmu.2022.874878","volume":"13","author":"Y Xia","year":"2022","unstructured":"Xia Y, Shi H, Qian C, Han H, Lu K, Tao R, Gu R, Zhao Y, Wei Z, Lu Y (2022) Modulation of gut microbiota by magnesium isoglycyrrhizinate mediates enhancement of intestinal barrier function and amelioration of methotrexate-induced liver injury. Front Immunol 13:874878","journal-title":"Front Immunol"},{"key":"3242_CR28","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1080\/19490976.2020.1736457","volume":"11","author":"L Yu","year":"2020","unstructured":"Yu L, Wang L, Yi H, Wu X (2020) Beneficial effects of LRP6-CRISPR on prevention of alcohol-related liver injury surpassed fecal microbiota transplant in a rat model. Gut Microbes 11:1015\u20131029","journal-title":"Gut Microbes"}],"updated-by":[{"DOI":"10.1007\/s00210-025-04433-z","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000}}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03242-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-024-03242-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03242-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T20:16:00Z","timestamp":1757103360000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-024-03242-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,26]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["3242"],"URL":"https:\/\/doi.org\/10.1007\/s00210-024-03242-0","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s00210-025-04433-z","asserted-by":"object"}]},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,26]]},"assertion":[{"value":"1 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2025","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00210-025-04433-z","URL":"https:\/\/doi.org\/10.1007\/s00210-025-04433-z","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Research Ethics Committee at King Faisal University, Saudi Arabia, reviewed the study proposal and granted ethical approval (KFU-REC-2023-SEP-ETHICS1065) to the research project.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}