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The current study investigated the detrimental impact of ME on the cerebellum and spinal cord tissues in 6\u20138-week-old female rats. We also evaluated the neuroprotective efficacy of \u03b2-caryophyllene (BC) against spinal and cerebellar changes caused by ME. Thirty-five young Wistar albino rats were randomly chosen and assigned into five groups: control (CO), olive oil (OI), ME, BC, ME\u2009+\u2009BC. All samples were analysed by means of unbiased stereological, biochemical, immunohistochemical, and histopathological methods. Our biochemical findings showed that SOD level was significantly increased in the ME group compared to the CO group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). We additionally detected a statistically significant decrease in the number of cerebellar Purkinje cells and granular cells, as well as spinal motor neuron in the ME group compared to the CO group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). In the ME\u2009+\u2009BC group, the number of Purkinje cells, granular cells, and spinal motor neurons was significantly higher compared to the ME group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Decreased SOD activity in the ME\u2009+\u2009BC group was also detected than the ME group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Immunohistochemical (the tumour necrosis factor-alpha (TNF-\u03b1)) and histopathological examinations also exhibited crucial information in each of the group. Taken together, ME exposure was associated with neurotoxicity in the cerebellum and spinal cord tissues. BC treatment also mitigated ME-induced neurological alteration, which may imply its potential therapeutic benefits.\n                  <\/jats:p>","DOI":"10.1007\/s00210-024-03268-4","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T03:02:07Z","timestamp":1720753327000},"page":"10175-10189","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Promising the potential of \u03b2-caryophyllene on mercury chloride\u2013induced alteration in cerebellum and spinal cord of young Wistar albino rats"],"prefix":"10.1007","volume":"397","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6093-3588","authenticated-orcid":false,"given":"Ahmad","family":"Yahyazadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih Mehmet","family":"Gur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,12]]},"reference":[{"key":"3268_CR1","first-page":"102","volume":"64","author":"SA Abd Elghani","year":"2020","unstructured":"Abd Elghani SA, Oda SS, Tohamy HG, Hashem MA (2020) Hematological, biochemical and histopathological studies on the prophylactic effect of zinc sulphate against mercuric chloride toxicity in rats. 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