{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T03:11:35Z","timestamp":1777086695327,"version":"3.51.4"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100015034","name":"Shahid Sadoughi University of Medical Sciences","doi-asserted-by":"publisher","award":["6536"],"award-info":[{"award-number":["6536"]}],"id":[{"id":"10.13039\/501100015034","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s00210-024-03284-4","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T10:02:27Z","timestamp":1721037747000},"page":"10203-10213","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Methane-rich saline ameliorates depressive-like behaviors during chronic unpredictable mild stress (CUMS)"],"prefix":"10.1007","volume":"397","author":[{"given":"Mohammad Ghaffari","family":"Nasab","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Ebrahim","family":"Rezvani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Mohammad Sadegh","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh Zare","family":"Mehrjerdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,15]]},"reference":[{"key":"3284_CR1","doi-asserted-by":"publisher","first-page":"135594","DOI":"10.1016\/j.neulet.2020.135594","volume":"744","author":"MA Abame","year":"2021","unstructured":"Abame MA, He Y, Wu S, Xie Z, Zhang J, Gong X, Wu C, Shen J (2021) Chronic administration of synthetic cannabidiol induces antidepressant effects involving modulation of serotonin and noradrenaline levels in the hippocampus. Neurosci Lett 744:135594. https:\/\/doi.org\/10.1016\/j.neulet.2020.135594","journal-title":"Neurosci Lett"},{"key":"3284_CR2","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.neubiorev.2018.12.002","volume":"99","author":"S Antoniuk","year":"2019","unstructured":"Antoniuk S, Bijata M, Ponimaskin E, Wlodarczyk J (2019) Chronic unpredictable mild stress for modeling depression in rodents: Meta-analysis of model reliability. Neurosci Biobehav Rev 99:101\u2013116. https:\/\/doi.org\/10.1016\/j.neubiorev.2018.12.002","journal-title":"Neurosci Biobehav Rev"},{"key":"3284_CR3","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.yebeh.2014.01.017","volume":"38","author":"GM Arisi","year":"2014","unstructured":"Arisi GM (2014) Nervous and immune systems signals and connections: cytokines in hippocampus physiology and pathology. Epilepsy Behav 38:43\u201347. https:\/\/doi.org\/10.1016\/j.yebeh.2014.01.017","journal-title":"Epilepsy Behav"},{"issue":"7","key":"3284_CR4","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1016\/j.drudis.2020.05.001","volume":"25","author":"S Bhatt","year":"2020","unstructured":"Bhatt S, Nagappa AN, Patil CR (2020) Role of oxidative stress in depression. Drug Discov Today 25(7):1270\u20131276. https:\/\/doi.org\/10.1016\/j.drudis.2020.05.001","journal-title":"Drug Discov Today"},{"issue":"4","key":"3284_CR5","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1097\/ccm.0b013e31823dae05","volume":"40","author":"M Boros","year":"2012","unstructured":"Boros M, Ghyczy M, \u00c9rces D, Varga G, T\u0151k\u00e9s T, Kupai K, Torday C, Kaszaki J (2012) The anti-inflammatory effects of methane. Crit Care Med 40(4):1269\u201378. https:\/\/doi.org\/10.1097\/ccm.0b013e31823dae05","journal-title":"Crit Care Med"},{"issue":"10","key":"3284_CR6","doi-asserted-by":"publisher","first-page":"4124","DOI":"10.1038\/s41380-023-02229-2","volume":"28","author":"A Borsini","year":"2023","unstructured":"Borsini A, Giacobbe J, Mandal G, Boldrini M (2023) Acute and long-term effects of adolescence stress exposure on rodent adult hippocampal neurogenesis, cognition, and behaviour. Mol Psychiatry 28(10):4124\u20134137. https:\/\/doi.org\/10.1038\/s41380-023-02229-2","journal-title":"Mol Psychiatry"},{"key":"3284_CR7","doi-asserted-by":"publisher","first-page":"113960","DOI":"10.1016\/j.bbr.2022.113960","volume":"432","author":"K Bosch","year":"2022","unstructured":"Bosch K, Sbrini G, Burattini I, Nieuwenhuis D, Calabrese F, Schubert D, Henckens MJ, Homberg JR (2022) Repeated testing modulates chronic unpredictable mild stress effects in male rats. Behav Brain Res 432:113960. https:\/\/doi.org\/10.1016\/j.bbr.2022.113960","journal-title":"Behav Brain Res"},{"key":"3284_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2015.11.017","volume":"90","author":"O Chen","year":"2016","unstructured":"Chen O, Ye Z, Cao Z, Manaenko A, Ning K, Zhai X, Zhang R, Zhang T, Chen X, Liu W (2016) Methane attenuates myocardial ischemia injury in rats through anti-oxidative, anti-apoptotic and anti-inflammatory actions. Free Radic Biol Med 90:1\u201311. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2015.11.017","journal-title":"Free Radic Biol Med"},{"key":"3284_CR9","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.1007\/s11064-013-1122-0","volume":"38","author":"S Jain","year":"2013","unstructured":"Jain S, Banerjee BD, Ahmed RS, Arora VK, Mediratta PK (2013) Possible role of oxidative stress and brain derived neurotrophic factor in triazophos induced cognitive impairment in rats. Neurochem Res 38:2136\u20132147. https:\/\/doi.org\/10.1007\/s11064-013-1122-0","journal-title":"Neurochem Res"},{"key":"3284_CR10","doi-asserted-by":"publisher","first-page":"1912746","DOI":"10.1155\/2018\/1912746","volume":"201","author":"Y Jia","year":"2018","unstructured":"Jia Y, Li Z, Liu C, Zhang J (2018) Methane medicine: a rising star gas with powerful anti-inflammation, antioxidant, and antiapoptosis properties. Oxid Med Cell Longev 201:1912746. https:\/\/doi.org\/10.1155\/2018\/1912746","journal-title":"Oxid Med Cell Longev"},{"issue":"2","key":"3284_CR11","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.bbr.2005.11.019","volume":"168","author":"SA Johnson","year":"2006","unstructured":"Johnson SA, Fournier NM, Kalynchuk LE (2006) Effect of different doses of corticosterone on depression-like behavior and HPA axis responses to a novel stressor. Behav Brain Res 168(2):280\u2013288. https:\/\/doi.org\/10.1016\/j.bbr.2005.11.019","journal-title":"Behav Brain Res"},{"issue":"9","key":"3284_CR12","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.3390\/antiox10091439","volume":"10","author":"G Juszczyk","year":"2021","unstructured":"Juszczyk G, Mikulska J, Kasperek K, Pietrzak D, Mrozek W, Herbet M (2021) Chronic stress and oxidative stress as common factors of the pathogenesis of depression and Alzheimer\u2019s disease: the role of antioxidants in prevention and treatment. Antioxidants 10(9):1439. https:\/\/doi.org\/10.3390\/antiox10091439","journal-title":"Antioxidants"},{"issue":"5","key":"3284_CR13","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.metabol.2005.01.009","volume":"54","author":"M Kalia","year":"2005","unstructured":"Kalia M (2005) Neurobiological basis of depression: an update. Metab 54(5):24\u201327. https:\/\/doi.org\/10.1016\/j.metabol.2005.01.009","journal-title":"Metab"},{"issue":"9","key":"3284_CR14","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1101\/lm.037291.114","volume":"22","author":"EJ Kim","year":"2015","unstructured":"Kim EJ, Pellman B, Kim JJ (2015) Stress effects on the hippocampus: a critical review. Learn Mem 22(9):411\u2013416. https:\/\/doi.org\/10.1101\/lm.037291.114","journal-title":"Learn Mem"},{"key":"3284_CR15","doi-asserted-by":"publisher","first-page":"3852450","DOI":"10.1155\/2020\/3852450","volume":"2020","author":"M Li","year":"2020","unstructured":"Li M, Gao W, Ji L, Li J, Jiang W, Ji W (2020) Methane saline ameliorates traumatic brain injury through anti-inflammatory, antiapoptotic, and antioxidative effects by activating the Wnt signalling pathway. Biomed Res Int 2020:3852450. https:\/\/doi.org\/10.1155\/2020\/3852450","journal-title":"Biomed Res Int"},{"issue":"6","key":"3284_CR16","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s12264-021-00638-3","volume":"37","author":"Z Li","year":"2021","unstructured":"Li Z, Ruan M, Chen J, Fang Y (2021) Major depressive disorder: advances in neuroscience research and translational applications. Neurosci Bull 37(6):863\u2013880. https:\/\/doi.org\/10.1007\/s12264-021-00638-3","journal-title":"Neurosci Bull"},{"key":"3284_CR17","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.jad.2023.04.134","volume":"334","author":"H Li","year":"2023","unstructured":"Li H, Song L, Cen M, Fu X, Gao X, Zuo Q, Wu J (2023) Oxidative balance scores and depressive symptoms: mediating effects of oxidative stress and inflammatory factors. J J Affect Disord 334:205\u2013212. https:\/\/doi.org\/10.1016\/j.jad.2023.04.134","journal-title":"J J Affect Disord"},{"key":"3284_CR18","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.brainres.2016.05.037","volume":"1646","author":"L Liu","year":"2016","unstructured":"Liu L, Sun Q, Wang R, Chen Z, Wu J, Xia F, Xq Fan (2016) Methane attenuates retinal ischemia\/reperfusion injury via anti-oxidative and anti-apoptotic pathways. Brain Res 1646:327\u2013333. https:\/\/doi.org\/10.1016\/j.brainres.2016.05.037","journal-title":"Brain Res"},{"key":"3284_CR19","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3389\/fmed.2017.00195","volume":"4","author":"AT M\u00e9sz\u00e1ros","year":"2017","unstructured":"M\u00e9sz\u00e1ros AT, Szil\u00e1gyi \u00c1L, Juh\u00e1sz L, Tuboly E, \u00c9rces D, Varga G, Hartmann P (2017) Mitochondria as sources and targets of methane. Front Med (Lausanne) 4:195. https:\/\/doi.org\/10.3389\/fmed.2017.00195","journal-title":"Front Med (Lausanne)"},{"issue":"40","key":"3284_CR20","doi-asserted-by":"publisher","first-page":"11336","DOI":"10.1073\/pnas.1605246113","volume":"113","author":"KR Mifsud","year":"2016","unstructured":"Mifsud KR, Reul JM (2016) Acute stress enhances heterodimerization and binding of corticosteroid receptors at glucocorticoid target genes in the hippocampus. PNAS 113(40):11336\u201311341. https:\/\/doi.org\/10.1073\/pnas.1605246113","journal-title":"PNAS"},{"key":"3284_CR21","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.bbr.2016.09.004","volume":"316","author":"GR Mileva","year":"2017","unstructured":"Mileva GR, Rooke J, Ismail N, Bielajew C (2017) Corticosterone and immune cytokine characterization following environmental manipulation in female WKY rats. Behav Brain Res 316:197\u2013204. https:\/\/doi.org\/10.1016\/j.bbr.2016.09.004","journal-title":"Behav Brain Res"},{"key":"3284_CR22","doi-asserted-by":"publisher","first-page":"6436","DOI":"10.1007\/s12035-016-0143-5","volume":"54","author":"S Niknazar","year":"2017","unstructured":"Niknazar S, Nahavandi A, Peyvandi AA, Peyvandi H, Zare Mehrjerdi F, Karimi M (2017) Effect of maternal stress prior to conception on hippocampal BDNF signaling in rat offspring. Mol Neurobiol 54:6436\u20136445. https:\/\/doi.org\/10.1007\/s12035-016-0143-5","journal-title":"Mol Neurobiol"},{"issue":"1","key":"3284_CR23","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1097\/psy.0000000000000009","volume":"76","author":"P Palta","year":"2014","unstructured":"Palta P, Samuel LJ, MillerIII ER, Szanton SL (2014) Depression and oxidative stress: results from a meta-analysis of observational studies. Psychosom Med 76(1):12. https:\/\/doi.org\/10.1097\/psy.0000000000000009","journal-title":"Psychosom Med"},{"issue":"1","key":"3284_CR24","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s40635-019-0278-6","volume":"7","author":"MZ Poles","year":"2019","unstructured":"Poles MZ, Juh\u00e1sz L, Boros M (2019) Methane and inflammation - a review (fight fire with fire). Intensive Care Med Exp 7(1):68. https:\/\/doi.org\/10.1186\/s40635-019-0278-6","journal-title":"Intensive Care Med Exp"},{"issue":"6","key":"3284_CR25","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1007\/s00210-023-02405-9","volume":"396","author":"M Salari","year":"2023","unstructured":"Salari M, Zare Mehrjerdi F, Yadegari M, Rezvani ME, Shahrokhi Raeini A (2023) Antidepressant-like effect of endogenous SO2 on depression caused by chronic unpredictable mild stress. Naunyn Schmiedebergs Arch Pharmacol 396(6):1325\u20131336. https:\/\/doi.org\/10.1007\/s00210-023-02405-9","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"1","key":"3284_CR26","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.psc.2011.12.001","volume":"35","author":"RV Saveanu","year":"2012","unstructured":"Saveanu RV, Nemeroff CB (2012) Etiology of depression: genetic and environmental factors. Psychiatric Clin 35(1):51\u201371. https:\/\/doi.org\/10.1016\/j.psc.2011.12.001","journal-title":"Psychiatric Clin"},{"key":"3284_CR27","doi-asserted-by":"publisher","first-page":"101708","DOI":"10.1016\/j.lmot.2021.101708","volume":"73","author":"M Shahidpour","year":"2021","unstructured":"Shahidpour M, Zare FM, Mozayan MR, Marefati N, Hosseini H (2021) The effects of frankincense extract on depression and anxiety-like behaviors induced by lipopolysaccharide in rats. Learn Motiv 73:101708. https:\/\/doi.org\/10.1016\/j.lmot.2021.101708","journal-title":"Learn Motiv"},{"key":"3284_CR28","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.jns.2016.08.055","volume":"369","author":"M Shen","year":"2016","unstructured":"Shen M, Fan D, Zang Y, Chen Y, Zhu K, Cai Z, Liu Y, Sun X, Liu J, Gong J (2016) Neuroprotective effects of methane-rich saline on experimental acute carbon monoxide toxicity. J Neurol Sci 369:361\u2013367. https:\/\/doi.org\/10.1016\/j.jns.2016.08.055","journal-title":"J Neurol Sci"},{"key":"3284_CR29","doi-asserted-by":"publisher","first-page":"545823","DOI":"10.3389\/fpsyt.2020.545823","volume":"11","author":"M Song","year":"2020","unstructured":"Song M, Zhang J, Li X, Liu Y, Wang T, Yan Z, Chen J (2020) Effects of Xiaoyaosan on depressive-like behaviors in rats with chronic unpredictable mild stress through HPA axis induced astrocytic activities. Front Psychiatry 11:545823. https:\/\/doi.org\/10.3389\/fpsyt.2020.545823","journal-title":"Front Psychiatry"},{"issue":"3","key":"3284_CR30","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s00213-021-05982-w","volume":"239","author":"T Strekalova","year":"2022","unstructured":"Strekalova T, Liu Y, Kiselev D, Khairuddin S, Chiu JLY, Lam J, Chan YS, Pavlov D, Proshin A, Lesch KP (2022) Chronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives. Psychopharmacol 239(3):663\u2013693. https:\/\/doi.org\/10.1007\/s00213-021-05982-w","journal-title":"Psychopharmacol"},{"issue":"1","key":"3284_CR31","doi-asserted-by":"publisher","first-page":"e0146363","DOI":"10.1371\/journal.pone.0146363","volume":"11","author":"G Strifler","year":"2016","unstructured":"Strifler G, Tuboly E, Sz\u00e9l E, Kaszonyi E, Cao C, Kaszaki J, M\u00e9sz\u00e1ros A, Boros M, Hartmann P (2016) Inhaled methane limits the mitochondrial electron transport chain dysfunction during experimental liver ischemia-reperfusion injury. PLoS One 11(1):e0146363. https:\/\/doi.org\/10.1371\/journal.pone.0146363","journal-title":"PLoS One"},{"key":"3284_CR32","doi-asserted-by":"publisher","unstructured":"Wang L, Yao Y, He R, Meng Y, Li N, Zhang D, Xu J, Chen O, Cui J, Bian J (2017a) Methane ameliorates spinal cord ischemia-reperfusion injury in rats: antioxidant, anti-inflammatory and anti-apoptotic activity mediated by Nrf2 activation. Free Radic Biol Med 103:69\u201386. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2016.12.014","DOI":"10.1016\/j.freeradbiomed.2016.12.014"},{"key":"3284_CR33","doi-asserted-by":"publisher","unstructured":"Wang W, Huang X, Li J, Sun A, Yu J, Xie N, Xi Y, Ye X (2017b) Methane suppresses microglial activation related to oxidative, inflammatory, and apoptotic injury during spinal cord injury in rats. Oxid Med Cell Longev 2017:2190897. https:\/\/doi.org\/10.1155\/2017\/2190897","DOI":"10.1155\/2017\/2190897"},{"key":"3284_CR34","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1007\/s11064-018-2566-z","volume":"43","author":"C Wang","year":"2018","unstructured":"Wang C, Gan D, Wu J, Liao M, Liao X, Ai W (2018) Honokiol exerts antidepressant effects in rats exposed to chronic unpredictable mild stress by regulating brain derived neurotrophic factor level and hypothalamus\u2013pituitary\u2013adrenal axis activity. Neurochem Res 43:1519\u20131528. https:\/\/doi.org\/10.1007\/s11064-018-2566-z","journal-title":"Neurochem Res"},{"issue":"3","key":"3284_CR35","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s11064-018-2566-z","volume":"40","author":"F Wang","year":"2020","unstructured":"Wang F, Wang F, Li F, Wang D, Li H, He X, Zhan J (2020) Methane attenuates lung ischemia-reperfusion injury via regulating PI3K-AKT-NF\u03baB signaling pathway. J Recept Signal Transduct Res 40(3):209\u2013217. https:\/\/doi.org\/10.1007\/s11064-018-2566-z","journal-title":"J Recept Signal Transduct Res"},{"key":"3284_CR36","doi-asserted-by":"publisher","first-page":"148000","DOI":"10.1016\/j.brainres.2022.148000","volume":"1791","author":"Y Wang","year":"2022","unstructured":"Wang Y, Wang C, Zhang D, Wang L, Wang H, Hu B, Bo L (2022) Methane-rich saline protects against sepsis-associated cognitive deficits in mice. Brain Res 1791:148000. https:\/\/doi.org\/10.1016\/j.brainres.2022.148000","journal-title":"Brain Res"},{"issue":"2","key":"3284_CR37","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.bbrc.2015.08.121","volume":"466","author":"J Wu","year":"2015","unstructured":"Wu J, Wang R, Ye Z, Sun X, Chen Z, Xia F, Sun Q, Liu L (2015) Protective effects of methane-rich saline on diabetic retinopathy via anti-inflammation in a streptozotocin-induced diabetic rat model. Biochem Biophys Res Commun 466(2):155\u2013161. https:\/\/doi.org\/10.1016\/j.bbrc.2015.08.121","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"3284_CR38","doi-asserted-by":"publisher","first-page":"e0150925","DOI":"10.1371\/journal.pone.0150925","volume":"11","author":"L Xin","year":"2016","unstructured":"Xin L, Sun X, Lou S (2016) Effects of methane-rich saline on the capability of one-time exhaustive exercise in male SD rats. PLoS One 11(3):e0150925. https:\/\/doi.org\/10.1371\/journal.pone.0150925","journal-title":"PLoS One"},{"issue":"2","key":"3284_CR39","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1097\/shk.0000000000000385","volume":"44","author":"Z Ye","year":"2015","unstructured":"Ye Z, Chen O, Zhang R, Nakao A, Fan D, Zhang T, Gu Z, Tao H, Sun X (2015) Methane attenuates hepatic ischemia\/reperfusion injury in rats through antiapoptotic, anti-inflammatory, and antioxidative actions. Shock 44(2):181\u20137. https:\/\/doi.org\/10.1097\/shk.0000000000000385","journal-title":"Shock"},{"key":"3284_CR40","doi-asserted-by":"publisher","first-page":"29359","DOI":"10.1038\/srep29359","volume":"6","author":"X Zhang","year":"2016","unstructured":"Zhang X, Li N, Shao H, Meng Y, Wang L, Wu Q, Yao Y, Li J, Bian J, Zhang Y, Deng X (2016) Methane limit LPS-induced NF-\u03baB\/MAPKs signal in macrophages and suppress immune response in mice by enhancing PI3K\/AKT\/GSK-3\u03b2-mediated IL-10 expression. Sci Rep 6:29359. https:\/\/doi.org\/10.1038\/srep29359","journal-title":"Sci Rep"},{"issue":"6","key":"3284_CR41","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.arcmed.2018.01.001","volume":"48","author":"B Zhang","year":"2017","unstructured":"Zhang B, Gao M, Shen J, He D (2017) Inhaled methane protects rats against neurological dysfunction induced by cerebral ischemia and reperfusion injury: PI3K\/Akt\/HO-1 pathway involved. Arch Med Res 48(6):520\u2013525. https:\/\/doi.org\/10.1016\/j.arcmed.2018.01.001","journal-title":"Arch Med Res"},{"key":"3284_CR42","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1007\/s11064-018-2490-2","volume":"43","author":"SZ Zhou","year":"2018","unstructured":"Zhou SZ, Zhou YL, Ji F, Li HL, Lv H, Zhang Y, Xu H (2018) Analgesic effect of methane rich saline in a rat model of chronic inflammatory pain. Neurochem Res 43:869\u2013877. https:\/\/doi.org\/10.1007\/s11064-018-2490-2","journal-title":"Neurochem Res"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03284-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-024-03284-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03284-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T07:09:59Z","timestamp":1732172999000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-024-03284-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,15]]},"references-count":42,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["3284"],"URL":"https:\/\/doi.org\/10.1007\/s00210-024-03284-4","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,15]]},"assertion":[{"value":"18 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All stages of work in this study were approved by the Ethics Committee of Yazd University of Medical Sciences which is in accordance with the US National Institutes of Health Publication guide for the care and use of laboratory animals with ethical code: IR.SSU.MEDICINE.REC.1398.209.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare that there are no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}