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This class of short non-coding RNAs (ncRNA) has roles in genomic stability, chromatin remodeling, messenger RNA (mRNA) integrity, and genome structure. We summarized the mechanisms underlying the biogenesis and regulatory molecular functions of piRNAs. Among all piRNAs studied in cancer, this review offers a comprehensive analysis of the emerging roles of piR-823 in various types of cancer, including colorectal, gastric, liver, breast, and renal cancers, as well as multiple myeloma. piR-823 has emerged as a crucial modulator of various cancer hallmarks through regulating multiple pathways. In the current review, we analyzed several databases and conducted an extensive literature search to explore the influence of piR-823 in carcinogenesis in addition to describing the potential application of piR-823 as prognostic and diagnostic markers as well as the therapeutic potential toward ncRNA precision.<\/jats:p>","DOI":"10.1007\/s00210-024-03308-z","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T11:02:57Z","timestamp":1722855777000},"page":"47-68","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["piR-823 tale as emerging cancer-hallmark molecular marker in different cancer types: a step-toward ncRNA-precision"],"prefix":"10.1007","volume":"398","author":[{"given":"Fatma H.","family":"Shaker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman F.","family":"Sanad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham","family":"Elghazaly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Min","family":"Hsia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2105-107X","authenticated-orcid":false,"given":"Nadia M.","family":"Hamdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,5]]},"reference":[{"issue":"22","key":"3308_CR1","doi-asserted-by":"publisher","first-page":"16484","DOI":"10.3390\/ijms242216484","volume":"24","author":"T Abaza","year":"2023","unstructured":"Abaza T, Abd MK, El-Aziz KA, Daniel PK, Papatsirou M, Fahmy SA, Hamdy NM, Kontos CK, Youness RA (2023) Emerging role of circular RNAs in hepatocellular carcinoma immunotherapy. 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Ethical approval is not required for the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}