{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:34:16Z","timestamp":1791488056992,"version":"4.3.4"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1007\/s00210-024-03362-7","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T11:02:27Z","timestamp":1723546947000},"page":"165-177","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Unraveling the rationale and conducting a comprehensive assessment of AdipoRon (adiponectin receptor agonist) as a candidate drug for diabetic nephropathy and cardiomyopathy prevention and intervention\u2014a systematic review"],"prefix":"10.1007","volume":"398","author":[{"given":"Lucas Fornari","family":"Laurindo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edvia Fornari","family":"Laurindo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vict\u00f3ria Dogani","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virg\u00ednia Maria Cavallari Strozze","family":"Catharin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ot\u00e1vio Augusto Garcia","family":"Simili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella Oliveira","family":"Barboza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor Cavallari Strozze","family":"Catharin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1tia Portero","family":"Sloan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Maria","family":"Barbalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,13]]},"reference":[{"key":"3362_CR1","doi-asserted-by":"crossref","unstructured":"Agarwal R (2021) Pathogenesis of diabetic nephropathy. Chronic Kidney Disease and Type 2 Diabetes. American Diabetes Association \u00a9 2021 by American Diabetes Association. All rights reserved. None of the contents may be reproduced without the written permission of the American Diabetes Association., Arlington (VA), pp. 2\u20137","DOI":"10.2337\/db20211-2"},{"key":"3362_CR2","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1177\/2047487319870344","volume":"27","author":"A Aimo","year":"2020","unstructured":"Aimo A, Castiglione V, Borrelli C, Saccaro LF, Franzini M, Masi S, Emdin M, Giannoni A (2020) Oxidative stress and inflammation in the evolution of heart failure: from pathophysiology to therapeutic strategies. Eur J Prev Cardiol 27:494\u2013510","journal-title":"Eur J Prev Cardiol"},{"key":"3362_CR3","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/B978-0-12-817962-8.00010-X","volume-title":"Biochemical and molecular basis of pediatric disease (fifth edition)","author":"R Amin","year":"2021","unstructured":"Amin R, Ahn S-Y, Moudgil A (2021) Chapter 7 - Kidney and urinary tract disorders. In: Dietzen D, Bennett M, Wong E, Haymond S (eds) Biochemical and molecular basis of pediatric disease (fifth edition). Academic Press, pp 167\u2013228"},{"key":"3362_CR4","doi-asserted-by":"crossref","first-page":"115871","DOI":"10.1016\/j.bcp.2023.115871","volume":"218","author":"SM Barbalho","year":"2023","unstructured":"Barbalho SM, M\u00e9ndez-S\u00e1nchez N, Fornari Laurindo L (2023) AdipoRon and ADP355, adiponectin receptor agonists, in metabolic-associated fatty liver disease (MAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review. Biochem Pharmacol 218:115871","journal-title":"Biochem Pharmacol"},{"key":"3362_CR5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11154-010-9131-7","volume":"11","author":"S Boudina","year":"2010","unstructured":"Boudina S, Abel ED (2010) Diabetic cardiomyopathy, causes and effects. Rev Endocr Metab Disord 11:31\u201339","journal-title":"Rev Endocr Metab Disord"},{"key":"3362_CR6","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.metabol.2018.02.004","volume":"85","author":"SR Choi","year":"2018","unstructured":"Choi SR, Lim JH, Kim MY, Kim EN, Kim Y, Choi BS, Kim YS, Kim HW, Lim KM, Kim MJ, Park CW (2018) Adiponectin receptor agonist AdipoRon decreased ceramide, and lipotoxicity, and ameliorated diabetic nephropathy. Metabolism 85:348\u2013360","journal-title":"Metabolism"},{"key":"3362_CR7","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1053\/j.jrn.2023.05.006","volume":"33","author":"ESUT de Oliveira","year":"2023","unstructured":"de Oliveira ESUT, Ramalho BJ, Laurindo LF, Tofano RJ, Rubira CJ, Guiguer EL, Barbalho SM, Flato UAP, Sloan KP, Araujo AC (2023) Effects of vitamin D supplementation in diabetic kidney disease: an systematic review. J Ren Nutr 33:618\u2013628","journal-title":"J Ren Nutr"},{"issue":"2","key":"3362_CR8","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3390\/biomedicines10020393","volume":"10","author":"NS Dhalla","year":"2022","unstructured":"Dhalla NS, Elimban V, Bartekova M, Adameova A (2022) Involvement of oxidative stress in the development of subcellular defects and heart disease. Biomedicines 10(2):393","journal-title":"Biomedicines"},{"key":"3362_CR9","doi-asserted-by":"crossref","first-page":"7644","DOI":"10.3390\/ijms22147644","volume":"22","author":"L Dilworth","year":"2021","unstructured":"Dilworth L, Facey A, Omoruyi F (2021) Diabetes mellitus and its metabolic complications: the role of adipose tissues. Int J Mol Sci 22:7644","journal-title":"Int J Mol Sci"},{"key":"3362_CR10","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.3390\/ijms20133299","volume":"20","author":"T Filardi","year":"2019","unstructured":"Filardi T, Ghinassi B, Di Baldassarre A, Tanzilli G, Morano S, Lenzi A, Basili S, Crescioli C (2019) Cardiomyopathy associated with diabetes: the central role of the cardiomyocyte. Int J Mol Sci 20:3299","journal-title":"Int J Mol Sci"},{"issue":"17","key":"3362_CR11","doi-asserted-by":"crossref","first-page":"6275","DOI":"10.3390\/ijms21176275","volume":"21","author":"U Galicia-Garcia","year":"2020","unstructured":"Galicia-Garcia U, Benito-Vicente A, Jebari S, Larrea-Sebal A, Siddiqi H, Uribe KB, Ostolaza H, Mart\u00edn C (2020) Pathophysiology of type 2 diabetes mellitus. Int J Mol Sci 21(17):6275","journal-title":"Int J Mol Sci"},{"key":"3362_CR12","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.3390\/biomedicines11041126","volume":"11","author":"N Ghosh","year":"2023","unstructured":"Ghosh N, Chacko L, Bhattacharya H, Vallamkondu J, Nag S, Dey A, Karmakar T, Reddy PH, Kandimalla R, Dewanjee S (2023) Exploring the complex relationship between diabetes and cardiovascular complications: understanding diabetic cardiomyopathy and promising therapies. Biomedicines 11:1126","journal-title":"Biomedicines"},{"key":"3362_CR13","first-page":"204201881983486","volume":"10","author":"GS Gulsin","year":"2019","unstructured":"Gulsin GS, Athithan L, McCann GP (2019) Diabetic cardiomyopathy: prevalence, determinants and potential treatments. Ther Adv Endocrinol Metab 10:2042018819834869","journal-title":"Ther Adv Endocrinol Metab"},{"key":"3362_CR14","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1038\/s41419-021-04326-y","volume":"12","author":"Y Han","year":"2021","unstructured":"Han Y, Xiong S, Zhao H, Yang S, Yang M, Zhu X, Jiang N, Xiong X, Gao P, Wei L, Xiao Y, Sun L (2021) Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy. Cell Death Dis 12:1031","journal-title":"Cell Death Dis"},{"key":"3362_CR15","doi-asserted-by":"crossref","first-page":"90","DOI":"10.4330\/wjc.v4.i4.90","volume":"4","author":"Z Hegab","year":"2012","unstructured":"Hegab Z, Gibbons S, Neyses L, Mamas MA (2012) Role of advanced glycation end products in cardiovascular disease. World J Cardiol 4:90\u2013102","journal-title":"World J Cardiol"},{"key":"3362_CR16","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.3390\/cells11182917","volume":"11","author":"SN Heyman","year":"2022","unstructured":"Heyman SN, Raz I, Dwyer JP, Weinberg Sibony R, Lewis JB, Abassi Z (2022) Diabetic proteinuria revisited: updated physiologic perspectives. Cells 11:2917","journal-title":"Cells"},{"key":"3362_CR17","doi-asserted-by":"publisher","first-page":"433","DOI":"10.3390\/kidneydial2030038","volume":"2","author":"EK Hoogeveen","year":"2022","unstructured":"Hoogeveen EK (2022) The epidemiology of diabetic kidney disease. Kidney and Dialysis 2:433\u2013442. https:\/\/doi.org\/10.3390\/kidneydial2030038","journal-title":"Kidney and Dialysis"},{"key":"3362_CR18","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/s41420-023-01553-4","volume":"9","author":"J-L Huo","year":"2023","unstructured":"Huo J-L, Feng Q, Pan S, Fu W-J, Liu Z, Liu Z (2023) Diabetic cardiomyopathy: early diagnostic biomarkers, pathogenetic mechanisms, and therapeutic interventions. Cell Death Discovery 9:256","journal-title":"Cell Death Discovery"},{"key":"3362_CR19","doi-asserted-by":"crossref","first-page":"6797","DOI":"10.1080\/10408398.2022.2043821","volume":"63","author":"VM Imaizumi","year":"2023","unstructured":"Imaizumi VM, Laurindo LF, Manzan B, Guiguer EL, Oshiiwa M, Otoboni A, Araujo AC, Tofano RJ, Barbalho SM (2023) Garlic: a systematic review of the effects on cardiovascular diseases. Crit Rev Food Sci Nutr 63:6797\u20136819","journal-title":"Crit Rev Food Sci Nutr"},{"key":"3362_CR20","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.3390\/biomedicines12051098","volume":"12","author":"R Jha","year":"2024","unstructured":"Jha R, Lopez-Trevino S, Kankanamalage HR, Jha JC (2024) Diabetes and renal complications: an overview on pathophysiology, biomarkers and therapeutic interventions. Biomedicines 12:1098","journal-title":"Biomedicines"},{"key":"3362_CR21","doi-asserted-by":"crossref","first-page":"1185317","DOI":"10.3389\/fimmu.2023.1185317","volume":"14","author":"Q Jin","year":"2023","unstructured":"Jin Q, Liu T, Qiao Y, Liu D, Yang L, Mao H, Ma F, Wang Y, Peng L, Zhan Y (2023) Oxidative stress and inflammation in diabetic nephropathy: role of polyphenols. Frontiers in Immunology 14:1185317","journal-title":"Frontiers in Immunology"},{"key":"3362_CR22","doi-asserted-by":"crossref","first-page":"4256","DOI":"10.2174\/092986710793348581","volume":"17","author":"N Kashihara","year":"2010","unstructured":"Kashihara N, Haruna Y, Kondeti VK, Kanwar YS (2010) Oxidative stress in diabetic nephropathy. Curr Med Chem 17:4256\u20134269","journal-title":"Curr Med Chem"},{"key":"3362_CR23","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/978-3-031-13177-6_17","volume-title":"Diabetes and cardiovascular disease","author":"J Kelly","year":"2023","unstructured":"Kelly J, Solomon R (2023) Diabetic Nephropathy. In: Johnstone M, Veves A (eds) Diabetes and cardiovascular disease. Springer International Publishing, Cham, pp 527\u2013550"},{"issue":"4","key":"3362_CR24","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3390\/biom12040542","volume":"12","author":"M Khalid","year":"2022","unstructured":"Khalid M, Petroianu G, Adem A (2022) Advanced glycation end products and diabetes mellitus: mechanisms and perspectives. Biomolecules 12(4):542","journal-title":"Biomolecules"},{"key":"3362_CR25","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1681\/ASN.2017060627","volume":"29","author":"Y Kim","year":"2018","unstructured":"Kim Y, Lim JH, Kim MY, Kim EN, Yoon HE, Shin SJ, Choi BS, Kim YS, Chang YS, Park CW (2018) The adiponectin receptor agonist AdipoRon ameliorates diabetic nephropathy in a model of type 2 diabetes. J Am Soc Nephrol 29:1108\u20131127","journal-title":"J Am Soc Nephrol"},{"key":"3362_CR26","doi-asserted-by":"crossref","first-page":"43","DOI":"10.23876\/j.krcp.21.068","volume":"41","author":"H Kim","year":"2022","unstructured":"Kim H, Lee J, Choi GH, Jeong HM, Kim SH, Gu JE, Yoo JJ, Han M, Kim HJ, Sung SA, Han SH, Kim YH, Yoon JW, Heo J, Oh KH (2022a) Quality of life in patients with diabetic nephropathy: findings from the KNOW-CKD (Korean Cohort Study for Outcomes in Patients with Chronic Kidney Disease) cohort. Kidney Res Clin Pract 41:43\u201357","journal-title":"Kidney Res Clin Pract"},{"key":"3362_CR27","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41419-022-04726-8","volume":"13","author":"Y Kim","year":"2022","unstructured":"Kim Y, Lim JH, Kim EN, Hong YA, Park HJ, Chung S, Choi BS, Kim YS, Park JY, Kim HW, Park CW (2022b) Adiponectin receptor agonist ameliorates cardiac lipotoxicity via enhancing ceramide metabolism in type 2 diabetic mice. Cell Death Dis 13:282","journal-title":"Cell Death Dis"},{"issue":"8","key":"3362_CR28","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.3390\/nu14081665","volume":"14","author":"LF Laurindo","year":"2022","unstructured":"Laurindo LF, Barbalho SM, Marquess AR, Grecco AIS, Goulart RA, Tofano RJ, Bishayee A (2022) Pomegranate (Punica granatum L.) and metabolic syndrome risk factors and outcomes: a systematic review of clinical studies. Nutrients 14(8):1665","journal-title":"Nutrients"},{"key":"3362_CR29","doi-asserted-by":"crossref","first-page":"109670","DOI":"10.1016\/j.jnutbio.2024.109670","volume":"131","author":"LF Laurindo","year":"2024","unstructured":"Laurindo LF, Rodrigues VD, Minniti G, de Carvalho ACA, Zutin TLM, DeLiberto LK, Bishayee A, Barbalho SM (2024a) Pomegranate (Punica granatum L.) phytochemicals target the components of metabolic syndrome. J Nutr Biochem 131:109670","journal-title":"J Nutr Biochem"},{"key":"3362_CR30","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1007\/s00210-023-02792-z","volume":"397","author":"LF Laurindo","year":"2024","unstructured":"Laurindo LF, Sosin AF, Lamas CB, de Alvares GR, Dos Santos Haber JF, Detregiachi CRP, Barbalho SM (2024b) Exploring the logic and conducting a comprehensive evaluation of AdipoRon-based adiponectin replacement therapy against hormone-related cancers-a systematic review. Naunyn Schmiedebergs Arch Pharmacol 397:2067\u20132082","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"3362_CR31","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/FJC.0000000000000789","volume":"75","author":"KE Leffler","year":"2020","unstructured":"Leffler KE, Abdel-Rahman AA (2020) Restoration of adiponectin-connexin43 signaling mitigates myocardial inflammation and dysfunction in diabetic female rats. J Cardiovasc Pharmacol 75:259\u2013267","journal-title":"J Cardiovasc Pharmacol"},{"key":"3362_CR32","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s10741-012-9313-3","volume":"18","author":"T Miki","year":"2013","unstructured":"Miki T, Yuda S, Kouzu H, Miura T (2013) Diabetic cardiomyopathy: pathophysiology and clinical features. Heart Fail Rev 18:149\u2013166","journal-title":"Heart Fail Rev"},{"issue":"12","key":"3362_CR33","first-page":"2270","volume":"13","author":"G Minniti","year":"2023","unstructured":"Minniti G, Laurindo LF, Machado NM, Duarte LG, Guiguer EL, Araujo AC, Dias JA, Lamas CB, Nunes YC, Bechara MD, BaldiJ\u00fanior E, Gimenes FB, Barbalho SM (2023) Mangifera indica L., by-products, and mangiferin on cardio-metabolic and other health conditions: a systematic review. Life (Basel) 13(12):2270","journal-title":"Life (Basel)"},{"key":"3362_CR34","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.3390\/ijms23073587","volume":"23","author":"K Nakamura","year":"2022","unstructured":"Nakamura K, Miyoshi T, Yoshida M, Akagi S, Saito Y, Ejiri K, Matsuo N, Ichikawa K, Iwasaki K, Naito T, Namba Y, Yoshida M, Sugiyama H, Ito H (2022) Pathophysiology and treatment of diabetic cardiomyopathy and heart failure in patients with diabetes mellitus. Int J Mol Sci 23:3587","journal-title":"Int J Mol Sci"},{"key":"3362_CR35","unstructured":"National Center for Biotechnology Information (2024) PubChem Compound Summary for\u00a0CID 16307093, AdipoRon. Retrieved August 10, 2024 from\u00a0https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/AdipoRon"},{"key":"3362_CR36","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hr\u00f3bjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71\u2013n71","journal-title":"BMJ"},{"key":"3362_CR37","doi-asserted-by":"crossref","first-page":"8878172","DOI":"10.1155\/2020\/8878172","volume":"2020","author":"VR Pasupuleti","year":"2020","unstructured":"Pasupuleti VR, Arigela CS, Gan SH, Salam SKN, Krishnan KT, Rahman NA, Jeffree MS (2020) A review on oxidative stress, diabetic complications, and the roles of honey polyphenols. Oxid Med Cell Longev 2020:8878172","journal-title":"Oxid Med Cell Longev"},{"key":"3362_CR38","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1134\/S0026893323040143","volume":"57","author":"IA Pobozheva","year":"2023","unstructured":"Pobozheva IA, Dracheva KV, Pchelina SN, Miroshnikova VV (2023) AdipoRon effect on expression of lipid metabolism genes in cultured human primary macrophages. Mol Biol 57:616\u2013623","journal-title":"Mol Biol"},{"key":"3362_CR39","doi-asserted-by":"crossref","first-page":"765","DOI":"10.3390\/biomedicines12040765","volume":"12","author":"E Radzioch","year":"2024","unstructured":"Radzioch E, D\u0105bek B, Balcerczyk-Lis M, Fr\u0105k W, Fularski P, M\u0142ynarska E, Rysz J, Franczyk B (2024) Diabetic cardiomyopathy\u2014from basics through diagnosis to treatment. Biomedicines 12:765","journal-title":"Biomedicines"},{"key":"3362_CR40","doi-asserted-by":"crossref","first-page":"695792","DOI":"10.3389\/fmed.2021.695792","volume":"8","author":"T Salvatore","year":"2021","unstructured":"Salvatore T, Pafundi PC, Galiero R, Albanese G, Di Martino A, Caturano A, Vetrano E, Rinaldi L, Sasso FC (2021) The diabetic cardiomyopathy: the contributing pathophysiological mechanisms. Frontiers in Medicine 8:695792","journal-title":"Frontiers in Medicine"},{"key":"3362_CR41","doi-asserted-by":"crossref","first-page":"836","DOI":"10.3390\/biom14070836","volume":"14","author":"E-S Scarpa","year":"2024","unstructured":"Scarpa E-S, Antonelli A, Balercia G, Sabatelli S, Maggi F, Caprioli G, Giacchetti G, Micucci M (2024) Antioxidant, anti-inflammatory, anti-diabetic, and pro-osteogenic activities of polyphenols for the treatment of two different chronic diseases: type 2 diabetes mellitus and osteoporosis. Biomolecules 14:836","journal-title":"Biomolecules"},{"key":"3362_CR42","doi-asserted-by":"crossref","first-page":"105","DOI":"10.31083\/j.fbl2703105","volume":"27","author":"A Shaito","year":"2022","unstructured":"Shaito A, Aramouni K, Assaf R, Parenti A, Orekhov A, Yazbi AE, Pintus G, Eid AH (2022) Oxidative stress-induced endothelial dysfunction in cardiovascular diseases. Front Biosci (landmark Ed) 27:105","journal-title":"Front Biosci (landmark Ed)"},{"key":"3362_CR43","doi-asserted-by":"crossref","first-page":"161","DOI":"10.12997\/jla.2022.11.2.161","volume":"11","author":"A Tarkhnishvili","year":"2022","unstructured":"Tarkhnishvili A, Koentges C, Pfeil K, Gollmer J, Byrne NJ, Vosko I, Lueg J, Vogelbacher L, Birkle S, Tang S, Bon-Nawul Mwinyella T, Hoffmann MM, Odening KE, Michel NA, Wolf D, Stachon P, Hilgendorf I, Wallner M, Ljubojevic-Holzer S, von Lewinski D, Rainer P, Sedej S, Sourij H, Bode C, Zirlik A, Bugger H (2022) Effects of short term adiponectin receptor agonism on cardiac function and energetics in diabetic db\/db mice. J Lipid Atheroscler 11:161\u2013177","journal-title":"J Lipid Atheroscler"},{"key":"3362_CR44","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/s41574-022-00690-7","volume":"18","author":"D Tomic","year":"2022","unstructured":"Tomic D, Shaw JE, Magliano DJ (2022) The burden and risks of emerging complications of diabetes mellitus. Nat Rev Endocrinol 18:525\u2013539","journal-title":"Nat Rev Endocrinol"},{"key":"3362_CR45","doi-asserted-by":"crossref","first-page":"50","DOI":"10.15420\/ecr.2018.33.1","volume":"14","author":"S Tsalamandris","year":"2019","unstructured":"Tsalamandris S, Antonopoulos AS, Oikonomou E, Papamikroulis GA, Vogiatzi G, Papaioannou S, Deftereos S, Tousoulis D (2019) The role of inflammation in diabetes: current concepts and future perspectives. Eur Cardiol 14:50\u201359","journal-title":"Eur Cardiol"},{"key":"3362_CR46","doi-asserted-by":"crossref","unstructured":"Usman MS, Khan MS, Butler J (2021) The interplay between diabetes, cardiovascular disease, and kidney disease. Chronic Kidney Disease and Type 2 Diabetes. American Diabetes Association \u00a9 2021 by American Diabetes Association. All rights reserved. None of the contents may be reproduced without the written permission of the American Diabetes Association., Arlington (VA), pp. 13\u201318","DOI":"10.2337\/db20211-13"},{"key":"3362_CR47","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1053\/j.ackd.2010.10.003","volume":"18","author":"PN Van Buren","year":"2011","unstructured":"Van Buren PN, Toto R (2011) Hypertension in diabetic nephropathy: epidemiology, mechanisms, and management. Adv Chronic Kidney Dis 18:28\u201341","journal-title":"Adv Chronic Kidney Dis"},{"key":"3362_CR48","unstructured":"Varghese RT, Jialal I (2024) Diabetic nephropathy. StatPearls. StatPearls Publishing Copyright \u00a9 2024, StatPearls Publishing LLC., Treasure Island (FL)"},{"key":"3362_CR49","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12967-023-04783-3","volume":"22","author":"Y Wang","year":"2024","unstructured":"Wang Y, Liu Y, Fang J, Xing X, Wang H, Shi X, Liu X, Niu T, Liu K (2024) Small-molecule agonist AdipoRon alleviates diabetic retinopathy through the AdipoR1\/AMPK\/EGR4 pathway. J Transl Med 22:2","journal-title":"J Transl Med"},{"key":"3362_CR50","first-page":"6104375","volume":"2020","author":"S Xiong","year":"2020","unstructured":"Xiong S, Han Y, Gao P, Zhao H, Jiang N, Sun L (2020) AdipoRon protects against tubular injury in diabetic nephropathy by inhibiting endoplasmic reticulum stress. Oxid Med Cell Longev 2020:6104375","journal-title":"Oxid Med Cell Longev"},{"issue":"11","key":"3362_CR51","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.3390\/pharmaceutics14112467","volume":"14","author":"W Yan","year":"2022","unstructured":"Yan W, Gao S, Zhang Q, Qi J, Liu G, Teng Y, Wang J, Yan S, Ji B (2022) AdipoRon inhibits neuroinflammation induced by deep hypothermic circulatory arrest involving the AMPK\/NF-\u03baB pathway in rats. Pharmaceutics 14(11):2467","journal-title":"Pharmaceutics"},{"key":"3362_CR52","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1007\/s11064-019-02794-5","volume":"44","author":"J Yu","year":"2019","unstructured":"Yu J, Zheng J, Lu J, Sun Z, Wang Z, Zhang J (2019) AdipoRon protects against secondary brain injury after intracerebral hemorrhage via alleviating mitochondrial dysfunction: possible involvement of AdipoR1\u2013AMPK\u2013PGC1\u03b1 pathway. Neurochem Res 44:1678\u20131689","journal-title":"Neurochem Res"},{"key":"3362_CR53","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.3390\/molecules26102946","volume":"26","author":"H Zatorski","year":"2021","unstructured":"Zatorski H, Salaga M, Zieli\u0144ska M, Majchrzak K, Binienda A, Kordek R, Ma\u0142ecka-Panas E, Fichna J (2021) AdipoRon, an orally active, synthetic agonist of AdipoR1 and AdipoR2 receptors has gastroprotective effect in experimentally induced gastric ulcers in mice. Molecules 26:2946","journal-title":"Molecules"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03362-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-024-03362-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03362-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T09:05:03Z","timestamp":1738400703000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-024-03362-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,13]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["3362"],"URL":"https:\/\/doi.org\/10.1007\/s00210-024-03362-7","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,13]]},"assertion":[{"value":"23 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human and animal subjects performed by any of the authors.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights and informed consent"}}]}}