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Clopidogrel (Clop), an antiplatelet drug known for its ability to prevent blood clots by inhibiting platelet aggregation, also has potential effects on oxidative stress and cell death. This study investigates Clop\u2019s protective role against Genta-induced nephrotoxicity, emphasizing the importance of the coagulation cascade. The 32 adult male albino rats were randomly assigned to four groups of eight (\n                    <jats:italic>n<\/jats:italic>\n                    = 8). The first group received only the vehicle. Genta was injected intraperitoneally at 100 mg\/kg\/day for 8 days in the second group. Groups 3 and 4 received oral Clop at 10 and 20 mg\/kg\/day for 1 week before Genta delivery and throughout the experiment. Renal tissue showed renal function tests, oxidative stress, pro-inflammatory cytokines, apoptotic markers, coagulation profile, and fibrin expression. Clop improved Genta-induced kidney function and histopathology. Clop substantially reduced pro-inflammatory cytokines, oxidative stress indicators, pro-apoptotic proteins, and fibrin protein. Clop also significantly boosted renal tissue anti-inflammatory and anti-apoptotic protein expression. Genta-induced nephrotoxicity involves oxidative stress, apoptosis, and coagulation system activation, according to studies. This study underscores that Genta-induced nephrotoxicity is associated with oxidative stress, apoptosis, and activation of the coagulation system. Clop\u2019s protective effects on nephrons are attributed to its anticoagulant, antioxidant, anti-inflammatory, and anti-apoptotic properties, presenting it as a promising therapeutic strategy against Genta-induced kidney damage.\n                  <\/jats:p>","DOI":"10.1007\/s00210-024-03380-5","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T08:02:20Z","timestamp":1725523340000},"page":"2609-2625","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clopidogrel protects against gentamicin-induced nephrotoxicity through targeting oxidative stress, apoptosis, and coagulation pathways"],"prefix":"10.1007","volume":"398","author":[{"given":"Asmaa A.","family":"Akila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania A.","family":"Gad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Gamal El-Din","family":"Ewees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal","family":"Abdul-Hamid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman S.","family":"Abdel-Reheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"3380_CR1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.bbrc.2011.05.127","volume":"410","author":"MS Abdel-Bakky","year":"2011","unstructured":"Abdel-Bakky MS, Hammad MA, Walker LA, Ashfaq MK (2011) Tissue factor dependent liver injury causes release of retinoid receptors (RXR-\u03b1 and RAR-\u03b1) as lipid droplets. 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