{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T18:17:17Z","timestamp":1775499437833,"version":"3.50.1"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Medizinische Hochschule Hannover (MHH)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Package inserts often cause displeasure among patients as they are perceived as misleading and confusing. The aim of this study was to find out how comprehensible, complete, and truthful package inserts are formulated in Germany. 311 package inserts for antipsychotics (mGPCR antagonists) and antidepressants (NE\/5-HT enhancers) from different manufacturers and dosages were analysed. The analysis criteria included the description of the effect, the warning of increased suicide risk, the explanation of interactions with co-medication, food and stimulants, as well as alcohol and the warning of impaired roadworthiness. In addition, the timeliness of the information regarding pregnancy and breastfeeding was checked and the symptoms mentioned under the topic of discontinuation symptoms and adverse drug reactions were compared. For most parameters, inconsistencies among various products, deficiencies and incorrect information were noted. This was particularly true for the items pregnancy and breastfeeding. Thus, package inserts for mGPCR antagonists and NE\/5-HT enhancers need to be updated and standardised urgently.\u00a0Such measures will reduce confusion among patients and increase drug adherence.<\/jats:p>","DOI":"10.1007\/s00210-024-03430-y","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T02:10:10Z","timestamp":1727230210000},"page":"2879-2895","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Insufficient correctness of package inserts for psychotropic drugs in Germany"],"prefix":"10.1007","volume":"398","author":[{"given":"Adina","family":"Arning","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Seifert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,20]]},"reference":[{"key":"3430_CR1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.4103\/japtr.JAPTR_110_20","volume":"12","author":"HAR Aburamadan","year":"2021","unstructured":"Aburamadan HAR, Sridhar SB, Tadross TM (2021) Assessment of potential drug interactions among psychiatric inpatients receiving antipsychotic therapy of a secondary care hospital, United Arab Emirates. J Adv Pharm Technol Res 12:45\u201351. https:\/\/doi.org\/10.4103\/japtr.JAPTR_110_20","journal-title":"J Adv Pharm Technol Res"},{"key":"3430_CR2","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1345\/aph.1D214","volume":"37","author":"DE Adson","year":"2003","unstructured":"Adson DE, Kotlyar M (2003) Premature ejaculation associated with citalopram withdrawal. Ann Pharmacother 37:1804\u20131806. https:\/\/doi.org\/10.1345\/aph.1D214","journal-title":"Ann Pharmacother"},{"key":"3430_CR3","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.31492","volume":"14","author":"AH Alhamoud","year":"2022","unstructured":"Alhamoud AH, Yatimi A, Towheri SA, Sharahili HA, Hawas AM (2022) Risperidone abruption-induced tardive dyskinesia in a six-year-old male patient with known autism and attention deficit hyperactivity disorder: a case report. Cureus 14:e31492. https:\/\/doi.org\/10.7759\/cureus.31492","journal-title":"Cureus"},{"key":"3430_CR4","unstructured":"Antwerpes F, Dr (2012) Potenzst\u00f6rungen.06.03.23. https:\/\/flexikon.doccheck.com\/de\/Potenzst%C3%B6rung. Accessed 6 Mar 2024"},{"key":"3430_CR5","doi-asserted-by":"publisher","first-page":"601","DOI":"10.3238\/arztebl.m2023.0153","volume":"120","author":"A Arning","year":"2023","unstructured":"Arning A, Seifert R (2023) Computer-assisted analysis of the intelligibility of package inserts. Dtsch Arztebl Int 120:601\u2013602. https:\/\/doi.org\/10.3238\/arztebl.m2023.0153","journal-title":"Dtsch Arztebl Int"},{"key":"3430_CR6","doi-asserted-by":"publisher","first-page":"202","DOI":"10.5414\/CN107731","volume":"82","author":"WJ Astorne Figari","year":"2014","unstructured":"Astorne Figari WJ, Herrmann S, Akogyeram C, Qian Q (2014) New onset hypertension following abrupt discontinuation of citalopram. Clin Nephrol 82:202\u2013204. https:\/\/doi.org\/10.5414\/CN107731","journal-title":"Clin Nephrol"},{"key":"3430_CR7","doi-asserted-by":"publisher","first-page":"152340","DOI":"10.1016\/j.comppsych.2022.152340","volume":"118","author":"F Biedermann","year":"2022","unstructured":"Biedermann F, Kurzthaler I, Haibach M, Pardeller S, Pichler T, Kemmler G, Holzner B, Hofer A (2022) Driving fitness in clinically stable outpatients with chronic schizophrenia. Compr Psychiatry 118:152340. https:\/\/doi.org\/10.1016\/j.comppsych.2022.152340","journal-title":"Compr Psychiatry"},{"key":"3430_CR8","doi-asserted-by":"publisher","first-page":"204512532110320","DOI":"10.1177\/20451253211032053","volume":"11","author":"G Blackman","year":"2021","unstructured":"Blackman G, Oloyede E (2021) Clozapine discontinuation withdrawal symptoms in schizophrenia. Ther Adv Psychopharmacol 11:20451253211032052. https:\/\/doi.org\/10.1177\/20451253211032053","journal-title":"Ther Adv Psychopharmacol"},{"key":"3430_CR9","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/j.1527-3458.2003.tb00245.x","volume":"9","author":"U Bonnet","year":"2003","unstructured":"Bonnet U (2003) Moclobemide: therapeutic use and clinical studies. CNS Drug Rev 9:97\u2013140. https:\/\/doi.org\/10.1111\/j.1527-3458.2003.tb00245.x","journal-title":"CNS Drug Rev"},{"key":"3430_CR10","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1055\/s-0031-1287781","volume":"45","author":"A Brunnauer","year":"2012","unstructured":"Brunnauer A, Laux G (2012) Driving ability under sertindole. Pharmacopsychiatry 45:47\u201350. https:\/\/doi.org\/10.1055\/s-0031-1287781","journal-title":"Pharmacopsychiatry"},{"key":"3430_CR11","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s00702-012-0833-8","volume":"120","author":"A Brunnauer","year":"2013","unstructured":"Brunnauer A, Laux G (2013) The effects of most commonly prescribed second generation antidepressants on driving ability: a systematic review\u202f: 70th Birthday Prof. Riederer J Neural Transm (Vienna) 120:225\u2013232. https:\/\/doi.org\/10.1007\/s00702-012-0833-8","journal-title":"Riederer J Neural Transm (Vienna)"},{"key":"3430_CR12","unstructured":"Bundesministerium der Justiz. (2019). Gesetz \u00fcber den Verkehr mit Arzneimitteln (Arzneimittelgesetz -AMG) \u00a711 Packungsbeilage. https:\/\/www.gesetze-im-internet.de\/amg_1976\/__11.html. Accessed\u00a011 10 2023\u00a0"},{"key":"3430_CR13","doi-asserted-by":"publisher","first-page":"177","DOI":"10.2165\/00003088-199937030-00001","volume":"37","author":"JT Callaghan","year":"1999","unstructured":"Callaghan JT, Bergstrom RF, Ptak LR, Beasley CM (1999) Olanzapine. Pharmacokinetic and Pharmacodynamic Profile Clin Pharmacokinet 37:177\u2013193. https:\/\/doi.org\/10.2165\/00003088-199937030-00001","journal-title":"Pharmacokinetic and Pharmacodynamic Profile Clin Pharmacokinet"},{"key":"3430_CR14","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1097\/00004714-199610000-00003","volume":"16","author":"NJ Coupland","year":"1996","unstructured":"Coupland NJ, Bell CJ, Potokar JP (1996) Serotonin reuptake inhibitor withdrawal. J Clin Psychopharmacol 16:356\u2013362. https:\/\/doi.org\/10.1097\/00004714-199610000-00003","journal-title":"J Clin Psychopharmacol"},{"key":"3430_CR15","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1177\/026988110201600314","volume":"16","author":"F Curtin","year":"2002","unstructured":"Curtin F, Berney P, Kaufmann C (2002) Moclobemide discontinuation syndrome predominantly presenting with influenza-like symptoms. J Psychopharmacol 16:271\u2013272. https:\/\/doi.org\/10.1177\/026988110201600314","journal-title":"J Psychopharmacol"},{"key":"3430_CR16","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1017\/neu.2013.60","volume":"26","author":"HY Elnazer","year":"2014","unstructured":"Elnazer HY, Baldwin DS (2014) Treatment with citalopram, but not with agomelatine, adversely affects sperm parameters: a case report and translational review. Acta Neuropsychiatr 26:125\u2013129. https:\/\/doi.org\/10.1017\/neu.2013.60","journal-title":"Acta Neuropsychiatr"},{"key":"3430_CR17","unstructured":"Embryotox Redaktion, (a). Embryotox Arzneimittel. https:\/\/www.embryotox.de\/arzneimittel. Accessed 24 Apr 2024"},{"key":"3430_CR18","unstructured":"Embryotox Redaktion, (b). Embryotox Citalopram. https:\/\/www.embryotox.de\/arzneimittel\/details\/ansicht\/medikament\/citalopram\/. Accessed 24 Apr 2024"},{"key":"3430_CR19","unstructured":"Embryotox Redaktion, (c). Embryotox Clozapin. https:\/\/www.embryotox.de\/arzneimittel\/details\/ansicht\/medikament\/clozapin\/. Accessed 24 Apr 2024"},{"key":"3430_CR20","unstructured":"Embryotox Redaktion, (d). Embryotox Escitalopram. https:\/\/www.embryotox.de\/arzneimittel\/details\/ansicht\/medikament\/escitalopram\/. Accessed 24 Apr 2024"},{"key":"3430_CR21","unstructured":"Embryotox Redaktion, (e). Embryotox Haloperidol. https:\/\/www.embryotox.de\/arzneimittel\/details\/ansicht\/medikament\/haloperidol\/. Accessed 24 Apr 2024"},{"key":"3430_CR22","unstructured":"Embryotox Redaktion, (f). Embryotox Melperon. https:\/\/www.embryotox.de\/arzneimittel\/details\/ansicht\/medikament\/melperon\/. Accessed 24 Apr 2024"},{"key":"3430_CR23","unstructured":"Embryotox Redaktion, (g). Embryotox Moclobemid. https:\/\/www.embryotox.de\/arzneimittel\/details\/ansicht\/medikament\/moclobemid\/. Accessed 24 Apr 2024"},{"key":"3430_CR24","unstructured":"Embryotox Redaktion, (h). Embryotox Olanzapin. https:\/\/www.embryotox.de\/arzneimittel\/details\/ansicht\/medikament\/olanzapin\/. Accessed 24 Apr 2024"},{"key":"3430_CR25","unstructured":"Embryotox Redaktion, (i). Embryotox Opipramol. https:\/\/www.embryotox.de\/arzneimittel\/details\/ansicht\/medikament\/opipramol\/. Accessed 24 Apr 2024"},{"key":"3430_CR26","unstructured":"Embryotox Redaktion, (j). Embryotox Quetiapin. https:\/\/www.embryotox.de\/arzneimittel\/details\/ansicht\/medikament\/quetiapin\/. Accessed 24 Apr 2024"},{"key":"3430_CR27","unstructured":"Embryotox Redaktion, (k). Embryotox Risperidon. https:\/\/www.embryotox.de\/arzneimittel\/details\/ansicht\/medikament\/risperidon\/. Accessed 24 Apr 2024"},{"key":"3430_CR28","unstructured":"Embryotox Redaktion, (l). Embryotox Sertralin. https:\/\/www.embryotox.de\/arzneimittel\/details\/ansicht\/medikament\/sertralin\/. Accessed 24 Apr 2024"},{"key":"3430_CR29","unstructured":"Embryotox Redaktion, (m). Embryotox Venlafaxin. https:\/\/www.embryotox.de\/arzneimittel\/details\/ansicht\/medikament\/venlafaxin\/. Accessed 24 Apr 2024"},{"key":"3430_CR30","unstructured":"Embryotox Redaktion, (n). Embryotox Zeitleiste. https:\/\/www.embryotox.de\/das-institut\/ueber-uns\/zeitleiste. Accessed 24 Apr 2024"},{"key":"3430_CR31","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1017\/S0033291721001549","volume":"53","author":"X Fu","year":"2023","unstructured":"Fu X, Qian Y, Jin X, Yu H, Wu H, Du L, Chen H, Shi Y (2023) Suicide rates among people with serious mental illness: a systematic review and meta-analysis. Psychol Med 53:351\u2013361. https:\/\/doi.org\/10.1017\/S0033291721001549","journal-title":"Psychol Med"},{"key":"3430_CR32","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3389\/fpsyt.2020.00032","volume":"11","author":"M Gahr","year":"2020","unstructured":"Gahr M, Hiemke C, K\u00f6lle MA (2020) Development of obsessive-compulsive symptoms following abrupt discontinuation of venlafaxine. Front Psychiatry 11:32. https:\/\/doi.org\/10.3389\/fpsyt.2020.00032","journal-title":"Front Psychiatry"},{"key":"3430_CR33","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1248\/cpb.c22-00651","volume":"71","author":"T Goromaru","year":"2023","unstructured":"Goromaru T, Fujita K, Mizumoto M, Ishizu T (2023) Quantification of risperidone contained in precipitates produced by tea catechins using nuclear magnetic resonance. Chem Pharm Bull (Tokyo) 71:134\u2013139. https:\/\/doi.org\/10.1248\/cpb.c22-00651","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"3430_CR34","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1159\/000026619","volume":"40","author":"HJ Grabe","year":"1999","unstructured":"Grabe HJ, Wolf T, Gr\u00e4tz S, Laux G (1999) The influence of clozapine and typical neuroleptics on information processing of the central nervous system under clinical conditions in schizophrenic disorders: implications for fitness to drive. Neuropsychobiology 40:196\u2013201. https:\/\/doi.org\/10.1159\/000026619","journal-title":"Neuropsychobiology"},{"key":"3430_CR35","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1208\/s12249-015-0358-1","volume":"17","author":"CY Gujjar","year":"2016","unstructured":"Gujjar CY, Rallabandi BC, Gannu R, Deulkar VS (2016) Development and optimization of a novel prolonged release formulation to resist alcohol-induced dose dumping. AAPS PharmSciTech 17:350\u2013357. https:\/\/doi.org\/10.1208\/s12249-015-0358-1","journal-title":"AAPS PharmSciTech"},{"key":"3430_CR36","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1176\/ajp.156.4.631","volume":"156","author":"M Hummer","year":"1999","unstructured":"Hummer M, Kemmler G, Kurz M, Kurzthaler I, Oberbauer H, Fleischhacker WW (1999) Sexual disturbances during clozapine and haloperidol treatment for schizophrenia. Am J Psychiatry 156:631\u2013633. https:\/\/doi.org\/10.1176\/ajp.156.4.631","journal-title":"Am J Psychiatry"},{"key":"3430_CR37","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1248\/yakushi.132.145","volume":"132","author":"H Ikeda","year":"2012","unstructured":"Ikeda H, Moriwaki H, Matsubara T, Yukawa M, Iwase Y, Yukawa E, Aki H (2012) Mechanism of interaction between risperidone and tea catechin (2) influence of presence of galloyl group in catechin on insoluble complex formation with risperidone. Yakugaku Zasshi 132:145\u2013153. https:\/\/doi.org\/10.1248\/yakushi.132.145","journal-title":"Yakugaku Zasshi"},{"key":"3430_CR38","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1248\/yakushi.130.1589","volume":"130","author":"H Ikeda","year":"2010","unstructured":"Ikeda H, Moriwaki H, Yukawa M, Iwase Y, Aki H (2010) Mechanism of interaction between risperidone and tea catechin(1)complex formation of risperidone with epigallocatechin gallate. Yakugaku Zasshi 130:1589\u20131595. https:\/\/doi.org\/10.1248\/yakushi.130.1589","journal-title":"Yakugaku Zasshi"},{"key":"3430_CR39","unstructured":"K\u00e4mmerer W (2011). Portr\u00e4t eines Enzyms - CYP1A2. https:\/\/www.arzneimitteltherapie.de\/heftarchiv\/2011\/09\/portrat-eines-enzyms-cyp1a2.html. Accessed 19 03 2023"},{"key":"3430_CR40","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-63825-5","volume-title":"Arzneiverordnungsreport 2021","author":"W Ludwig","year":"2021","unstructured":"Ludwig W, Muehlbauer B, Seifert R (2021) Arzneiverordnungsreport 2021. Springer-Verlag GmbH, Berlin"},{"key":"3430_CR41","doi-asserted-by":"publisher","unstructured":"Ludwig W, M\u00fchlbauer B, Seifert R (2024) Arzneiverordnungs-Report 2023. https:\/\/doi.org\/10.1007\/978-3-662-68371-2.","DOI":"10.1007\/978-3-662-68371-2"},{"key":"3430_CR42","doi-asserted-by":"publisher","unstructured":"Ludwig W, M\u00fchlbauer B, Seifert R (2023) Arzneiverordnungs-Report 2022. https:\/\/doi.org\/10.1007\/978-3-662-66303-5","DOI":"10.1007\/978-3-662-66303-5"},{"key":"3430_CR43","unstructured":"Menner S (2024) Lieferengp\u00e4sse bei Medikamenten erreichen neuen H\u00f6chstwert. https:\/\/www.br.de\/nachrichten\/wirtschaft\/lieferengpaesse-bei-medikamenten-erreichen-2023-hoechstwert,U2DmU5o. Accessed 07 03 2024\u00a0"},{"key":"3430_CR44","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1097\/00004850-199300730-00009","volume":"7","author":"R Minot","year":"1993","unstructured":"Minot R, Luthringer R, Macher JP (1993) Effect of moclobemide on the psychophysiology of sleep\/wake cycles: a neuroelectrophysiological study of depressed patients administered with moclobemide. Int Clin Psychopharmacol 7:181\u2013189. https:\/\/doi.org\/10.1097\/00004850-199300730-00009","journal-title":"Int Clin Psychopharmacol"},{"key":"3430_CR45","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1177\/0004867420965693","volume":"55","author":"K Monahan","year":"2021","unstructured":"Monahan K, Cuzens-Sutton J, Siskind D, Kisely S (2021) Quetiapine withdrawal: a systematic review. Aust N Z J Psychiatry 55:772\u2013783. https:\/\/doi.org\/10.1177\/0004867420965693","journal-title":"Aust N Z J Psychiatry"},{"key":"3430_CR46","doi-asserted-by":"publisher","first-page":"371","DOI":"10.2217\/pgs-2022-0006","volume":"23","author":"N Monroy-Jaramillo","year":"2022","unstructured":"Monroy-Jaramillo N, Mart\u00ednez-Maga\u00f1a JJ, P\u00e9rez-Aldana BE, Ortega-V\u00e1zquez A, Montalvo-Ortiz J, L\u00f3pez-L\u00f3pez M (2022) The role of alcohol intake in the pharmacogenetics of treatment with clozapine. Pharmacogenomics 23:371\u2013392. https:\/\/doi.org\/10.2217\/pgs-2022-0006","journal-title":"Pharmacogenomics"},{"key":"3430_CR47","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1177\/0269881115599385","volume":"29","author":"AL Montejo","year":"2015","unstructured":"Montejo AL, Deakin JFW, Gaillard R, Harmer C, Meyniel F, Jabourian A, Gabriel C, Gruget C, Klinge C, MacFayden C, Milligan H, Mullings E, Goodwin G (2015) Better sexual acceptability of agomelatine (25 and 50 mg) compared to escitalopram (20 mg) in healthy volunteers. A 9-week, placebo-controlled study using the PRSexDQ scale. J Psychopharmacol 29:1119\u20131128. https:\/\/doi.org\/10.1177\/0269881115599385","journal-title":"J Psychopharmacol"},{"key":"3430_CR48","unstructured":"Nink K, Schr\u00f6der H(2005) Zu Risiken und Nebenwirkungen: Lesen Sie die Packungsbeilage?. https:\/\/repository.publisso.de\/resource\/frl:2505767-1\/data. Accessed\u00a026 02 2023\u00a0"},{"key":"3430_CR49","doi-asserted-by":"publisher","first-page":"153","DOI":"10.5534\/wjmh.2012.30.3.153","volume":"30","author":"YW Park","year":"2012","unstructured":"Park YW, Kim Y, Lee JH (2012) Antipsychotic-induced sexual dysfunction and its management. World J Mens Health 30:153\u2013159. https:\/\/doi.org\/10.5534\/wjmh.2012.30.3.153","journal-title":"World J Mens Health"},{"key":"3430_CR50","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1038\/npp.2009.4","volume":"34","author":"RH Perlis","year":"2009","unstructured":"Perlis RH, Laje G, Smoller JW, Fava M, Rush AJ, McMahon FJ (2009) Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients. Neuropsychopharmacology 34:1819\u20131828. https:\/\/doi.org\/10.1038\/npp.2009.4","journal-title":"Neuropsychopharmacology"},{"key":"3430_CR51","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.urology.2022.01.026","volume":"164","author":"MN Pham","year":"2022","unstructured":"Pham MN, Siebert AL, Faw CA, Dubin JM, Hudnall MT, Lai JD, Wren JM, Bennett NE, Brannigan RE, Halpern JA (2022) Selective serotonin reuptake inhibitor (SSRI) use is not associated with impaired semen parameters. Urology 164:140\u2013144. https:\/\/doi.org\/10.1016\/j.urology.2022.01.026","journal-title":"Urology"},{"key":"3430_CR52","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/s1043-6618(03)00042-2","volume":"47","author":"B Pietrzak","year":"2003","unstructured":"Pietrzak B, Czarnecka E (2003) The effect of combined administration of ethanol and sertraline, fluoxetine and citalopram on rabbit EEG. Pharmacol Res 47:527\u2013534. https:\/\/doi.org\/10.1016\/s1043-6618(03)00042-2","journal-title":"Pharmacol Res"},{"issue":"Suppl 1","key":"3430_CR53","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1097\/00002826-199417001-00003","volume":"17","author":"JG Ramaekers","year":"1994","unstructured":"Ramaekers JG, van Veggel LM, O\u2019Hanlon JF (1994) A cross-study comparison of the effects of moclobemide and brofaromine on actual driving performance and estimated sleep. Clin Neuropharmacol 17(Suppl 1):9. https:\/\/doi.org\/10.1097\/00002826-199417001-00003","journal-title":"Clin Neuropharmacol"},{"key":"3430_CR54","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1177\/1933719110385708","volume":"18","author":"R Relwani","year":"2011","unstructured":"Relwani R, Berger D, Santoro N, Hickmon C, Nihsen M, Zapantis A, Werner M, Polotsky AJ, Jindal S (2011) Semen parameters are unrelated to BMI but vary with SSRI use and prior urological surgery. Reprod Sci 18:391\u2013397. https:\/\/doi.org\/10.1177\/1933719110385708","journal-title":"Reprod Sci"},{"key":"3430_CR55","unstructured":"Sch\u00f6ne L (2008) Mysterium Beipackzettel. https:\/\/www.welt.de\/wams_print\/article2406826\/Mysterium-Beipackzettel.html.Accessed\u00a014 05 2024\u00a0"},{"key":"3430_CR56","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1007\/s00210-020-01918-x","volume":"393","author":"R Seifert","year":"2020","unstructured":"Seifert R, Schirmer B (2020) A simple mechanistic terminology of psychoactive drugs: a proposal. Naunyn Schmiedebergs Arch Pharmacol 393:1331\u20131339. https:\/\/doi.org\/10.1007\/s00210-020-01918-x","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"3430_CR57","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.jpsychires.2004.04.006","volume":"39","author":"M Soyka","year":"2005","unstructured":"Soyka M, Winter C, Kagerer S, Brunnauer M, Laux G, M\u00f6ller H (2005) Effects of haloperidol and risperidone on psychomotor performance relevant to driving ability in schizophrenic patients compared to healthy controls. J Psychiatr Res 39:101\u2013108. https:\/\/doi.org\/10.1016\/j.jpsychires.2004.04.006","journal-title":"J Psychiatr Res"},{"key":"3430_CR58","doi-asserted-by":"publisher","unstructured":"Thom J, Jonas B, Reitzle L, Mauz E, H\u00f6lling H, Schulz M (2024) Trends in the diagnostic prevalence of mental disorders, 2012\u20132022\u2014Using nationwide outpatient claims data for mental health surveillance. Dtsch Arztebl Int arztebl.m2024.0052. https:\/\/doi.org\/10.3238\/arztebl.m2024.0052","DOI":"10.3238\/arztebl.m2024.0052"},{"key":"3430_CR59","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/j.1600-0447.1990.tb05318.x","volume":"360","author":"JW Tiller","year":"1990","unstructured":"Tiller JW (1990) Antidepressants, alcohol and psychomotor performance. Acta Psychiatr Scand Suppl 360:13\u201317. https:\/\/doi.org\/10.1111\/j.1600-0447.1990.tb05318.x","journal-title":"Acta Psychiatr Scand Suppl"},{"key":"3430_CR60","doi-asserted-by":"publisher","DOI":"10.1038\/s41443-023-00676-7","author":"M Tram","year":"2023","unstructured":"Tram M, Meyerson B, Welliver C, Inouye B (2023) Differences in sexual adverse events for premature ejaculation medications from a public federal database. Int J Impot Res. https:\/\/doi.org\/10.1038\/s41443-023-00676-7","journal-title":"Int J Impot Res"},{"key":"3430_CR61","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1002\/j.1552-4604.1997.tb04290.x","volume":"37","author":"SM Troy","year":"1997","unstructured":"Troy SM, Turner MB, Unruh M, Parker VD, Chiang ST (1997) Pharmacokinetic and pharmacodynamic evaluation of the potential drug interaction between venlafaxine and ethanol. J Clin Pharmacol 37:1073\u20131081. https:\/\/doi.org\/10.1002\/j.1552-4604.1997.tb04290.x","journal-title":"J Clin Pharmacol"},{"key":"3430_CR62","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1080\/15622970802688069","volume":"10","author":"N Ueda","year":"2009","unstructured":"Ueda N, Yoshimura R, Umene-Nakano W, Ikenouchi-Sugita A, Hori H, Hayashi K, Kodama Y, Nakamura J (2009) Grapefruit juice alters plasma sertraline levels after single ingestion of sertraline in healthy volunteers. World J Biol Psychiatry 10:832\u2013835. https:\/\/doi.org\/10.1080\/15622970802688069","journal-title":"World J Biol Psychiatry"},{"key":"3430_CR63","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/s1043-6618(05)80016-7","volume":"32","author":"IT Uzbay","year":"1995","unstructured":"Uzbay IT, Sever B, Celik T, Ayhan IH (1995) Investigation of the effects of moclobemide in chronic ethanol feeding rats. Pharmacol Res 32:287\u2013292. https:\/\/doi.org\/10.1016\/s1043-6618(05)80016-7","journal-title":"Pharmacol Res"},{"key":"3430_CR64","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.psyneuen.2009.01.013","volume":"34","author":"M van Bruggen","year":"2009","unstructured":"van Bruggen M, van Amelsvoort T, Wouters L, Dingemans P, de Haan L, Linszen D (2009) Sexual dysfunction and hormonal changes in first episode psychosis patients on olanzapine or risperidone. Psychoneuroendocrinology 34:989\u2013995. https:\/\/doi.org\/10.1016\/j.psyneuen.2009.01.013","journal-title":"Psychoneuroendocrinology"},{"key":"3430_CR65","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1159\/000516031","volume":"90","author":"J Wang","year":"2021","unstructured":"Wang J, Cosci F (2021) Neonatal Withdrawal Syndrome following late in utero exposure to selective serotonin reuptake inhibitors: a systematic review and meta-analysis of observational studies. Psychother Psychosom 90:299\u2013307. https:\/\/doi.org\/10.1159\/000516031","journal-title":"Psychother Psychosom"},{"key":"3430_CR66","first-page":"40","volume":"23","author":"R Weathermon","year":"1999","unstructured":"Weathermon R, Crabb DW (1999) Alcohol and medication interactions. Alcohol Res Health 23:40\u201354","journal-title":"Alcohol Res Health"},{"key":"3430_CR67","doi-asserted-by":"publisher","first-page":"520","DOI":"10.4088\/JCP.13m08624","volume":"75","author":"R Weisler","year":"2014","unstructured":"Weisler R, Montgomery SA, Earley WR, Szamosi J, Eriksson H (2014) Extended release quetiapine fumarate in patients with major depressive disorder: suicidality data from acute and maintenance studies. J Clin Psychiatry 75:520\u2013527. https:\/\/doi.org\/10.4088\/JCP.13m08624","journal-title":"J Clin Psychiatry"},{"key":"3430_CR68","doi-asserted-by":"publisher","unstructured":"Wilson MP, Chen N, Vilke GM, Castillo EM, MacDonald KS, Minassian A (2012) Olanzapine in ED patients: differential effects on oxygenation in patients with alcohol intoxication. Am J Emerg Med 30:1196\u20131201. https:\/\/doi.org\/10.1016\/j.ajem.2012.03.013","DOI":"10.1016\/j.ajem.2012.03.013"},{"key":"3430_CR69","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1097\/WNF.0000000000000139","volume":"39","author":"N Yasui-Furukori","year":"2016","unstructured":"Yasui-Furukori N, Hashimoto K, Tsuchimine S, Tomita T, Sugawara N, Ishioka M, Nakamura K (2016) Characteristics of escitalopram discontinuation syndrome: a preliminary study. Clin Neuropharmacol 39:125\u2013127. https:\/\/doi.org\/10.1097\/WNF.0000000000000139","journal-title":"Clin Neuropharmacol"},{"key":"3430_CR70","doi-asserted-by":"publisher","first-page":"291","DOI":"10.4088\/jcp.v58n0702","volume":"58","author":"J Zajecka","year":"1997","unstructured":"Zajecka J, Tracy KA, Mitchell S (1997) Discontinuation symptoms after treatment with serotonin reuptake inhibitors: a literature review. J Clin Psychiatry 58:291\u2013297. https:\/\/doi.org\/10.4088\/jcp.v58n0702","journal-title":"J Clin Psychiatry"},{"key":"3430_CR71","first-page":"11639","volume":"8","author":"Z Zhao","year":"2015","unstructured":"Zhao Z, Zhang H, Wang S, Chen X (2015) Sudden discontinuation and reinstitution of olanzapine-associated atypical neuroleptic malignant syndrome in a patient undergoing lung surgery. Int J Clin Exp Med 8:11639\u201311641","journal-title":"Int J Clin Exp Med"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03430-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-024-03430-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03430-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T10:49:26Z","timestamp":1742294966000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-024-03430-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,20]]},"references-count":71,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["3430"],"URL":"https:\/\/doi.org\/10.1007\/s00210-024-03430-y","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,20]]},"assertion":[{"value":"16 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This research was conducted according to the guidelines of good scientific practice of the Hannover Medical School () and officially registered as doctoral thesis project for Adina Arning. The Hannover Medical School follows the guidelines of the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable because publicly available data are used.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"R.S. is the Editor-in-Chief of Naunyn-Schmiedebergs Arch Pharmacol and follows the editorial guidelines of editors acting as authors ().","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}