{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:33:58Z","timestamp":1790253238635,"version":"4.1.0"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s00210-024-03461-5","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:11:42Z","timestamp":1728000702000},"page":"3843-3859","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The molecular mechanism of berberine affecting psoriasis skin inflammation by regulating keratinocyte pyroptosis via the p38 MAPK\/NF-\u03baB pathway"],"prefix":"10.1007","volume":"398","author":[{"given":"Wenfang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingzhi","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0762-8425","authenticated-orcid":false,"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,4]]},"reference":[{"key":"3461_CR1","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s13555-017-0183-4","volume":"7","author":"L Afifi","year":"2017","unstructured":"Afifi L, Danesh MJ, Lee KM, Beroukhim K, Farahnik B, Ahn RS, Yan D, Singh RK, Nakamura M, Koo J, Liao W (2017) Dietary behaviors in psoriasis: patient-reported outcomes from a U.S National Survey. Dermatol Ther (Heidelb) 7:227\u2013242","journal-title":"Dermatol Ther (Heidelb)"},{"key":"3461_CR2","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1038\/s41423-022-00922-w","volume":"19","author":"A Akbal","year":"2022","unstructured":"Akbal A, Dernst A, Lovotti M, Mangan MSJ, McManus RM, Latz E (2022) How location and cellular signaling combine to activate the NLRP3 inflammasome. Cell Mol Immunol 19:1201\u20131214","journal-title":"Cell Mol Immunol"},{"key":"3461_CR3","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1002\/ddr.21995","volume":"83","author":"C An","year":"2022","unstructured":"An C, Wu Y, Wu J, Liu H, Zhou S, Ge D, Dong R, You L, Hao Y (2022) Berberine ameliorates pulmonary inflammation in mice with influenza viral pneumonia by inhibiting NLRP3 inflammasome activation and gasdermin D-mediated pyroptosis. Drug Dev Res 83:1707\u20131721","journal-title":"Drug Dev Res"},{"key":"3461_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2021.105221","volume":"152","author":"M Cai","year":"2022","unstructured":"Cai M, Zhuang W, Lv E, Liu Z, Wang Y, Zhang W, Fu W (2022) Kaemperfol alleviates pyroptosis and microglia-mediated neuroinflammation in Parkinson\u2019s disease via inhibiting p38MAPK\/NF-kappaB signaling pathway. Neurochem Int 152:105221","journal-title":"Neurochem Int"},{"key":"3461_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2023.109223","volume":"143","author":"H Cai","year":"2023","unstructured":"Cai H, Li K, Yin Y, Ni X, Xu S (2023) Quercetin alleviates DEHP exposure-induced pyroptosis and cytokine expression changes in grass carp L8824 cell line by inhibiting ROS\/MAPK\/NF-kappaB pathway. Fish Shellfish Immunol 143:109223","journal-title":"Fish Shellfish Immunol"},{"key":"3461_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2022.110122","volume":"365","author":"Y Chen","year":"2022","unstructured":"Chen Y, Chen X, Liang S, Ou Y, Lin G, Hua L, Wu X, Zhou Y, Liu Z, Cai H, Yang Z, Hu W, Sun P (2022) Chlorquinaldol inhibits the activation of nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 inflammasome and ameliorates imiquimod-induced psoriasis-like dermatitis in mice. Chem Biol Interact 365:110122","journal-title":"Chem Biol Interact"},{"key":"3461_CR7","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1002\/ptr.7621","volume":"37","author":"J Chen","year":"2023","unstructured":"Chen J, Jiang Z, Liu X, Wang K, Fan W, Chen T, Li Z, Lin D (2023a) Berberine promotes the viability of random skin flaps via the PI3K\/Akt\/eNOS signaling pathway. Phytother Res 37:424\u2013437","journal-title":"Phytother Res"},{"key":"3461_CR8","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.2147\/DDDT.S401293","volume":"17","author":"L Chen","year":"2023","unstructured":"Chen L, Liu X, Wang X, Lu Z, Ye Y (2023b) Berberine alleviates acute lung injury in septic mice by modulating Treg\/Th17 homeostasis and downregulating NF-kappaB signaling. Drug Des Devel Ther 17:1139\u20131151","journal-title":"Drug Des Devel Ther"},{"key":"3461_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.111024","volume":"124","author":"JW Cheng","year":"2023","unstructured":"Cheng JW, Yu Y, Zong SY, Cai WW, Wang Y, Song YN, Xian H, Wei F (2023) Berberine ameliorates collagen-induced arthritis in mice by restoring macrophage polarization via AMPK\/mTORC1 pathway switching glycolytic reprogramming. Int Immunopharmacol 124:111024","journal-title":"Int Immunopharmacol"},{"key":"3461_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.664425","volume":"12","author":"SY Chuang","year":"2021","unstructured":"Chuang SY, Chen CY, Yang SC, Alalaiwe A, Lin CH, Fang JY (2021) 2,4-dimethoxy-6-methylbenzene-1,3-diol, a benzenoid from Antrodia cinnamomea, mitigates psoriasiform inflammation by suppressing MAPK\/NF-kappaB phosphorylation and GDAP1L1\/Drp1 translocation. Front Immunol 12:664425","journal-title":"Front Immunol"},{"key":"3461_CR11","doi-asserted-by":"publisher","first-page":"5898","DOI":"10.3390\/ijms22115898","volume":"22","author":"M Ciazynska","year":"2021","unstructured":"Ciazynska M, Olejniczak-Staruch I, Sobolewska-Sztychny D, Narbutt J, Skibinska M, Lesiak A (2021) The role of NLRP1, NLRP3, and AIM2 inflammasomes in psoriasis: review. Int J Mol Sci 22:5898","journal-title":"Int J Mol Sci"},{"key":"3461_CR12","doi-asserted-by":"publisher","first-page":"571","DOI":"10.3389\/fphar.2018.00571","volume":"9","author":"H Cui","year":"2018","unstructured":"Cui H, Cai Y, Wang L, Jia B, Li J, Zhao S, Chu X, Lin J, Zhang X, Bian Y, Zhuang P (2018) Berberine regulates Treg\/Th17 balance to treat ulcerative colitis through modulating the gut microbiota in the colon. Front Pharmacol 9:571","journal-title":"Front Pharmacol"},{"key":"3461_CR13","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/s41418-018-0106-7","volume":"26","author":"NM de Vasconcelos","year":"2019","unstructured":"de Vasconcelos NM, Van Opdenbosch N, Van Gorp H, Parthoens E, Lamkanfi M (2019) Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture. Cell Death Differ 26:146\u2013161","journal-title":"Cell Death Differ"},{"key":"3461_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.105682","volume":"74","author":"G Deng","year":"2019","unstructured":"Deng G, Chen W, Wang P, Zhan T, Zheng W, Gu Z, Wang X, Ji X, Sun Y (2019) Inhibition of NLRP3 inflammasome-mediated pyroptosis in macrophage by cycloastragenol contributes to amelioration of imiquimod-induced psoriasis-like skin inflammation in mice. Int Immunopharmacol 74:105682","journal-title":"Int Immunopharmacol"},{"key":"3461_CR15","doi-asserted-by":"publisher","first-page":"5545193","DOI":"10.1155\/2021\/5545193","volume":"2021","author":"B Ding","year":"2021","unstructured":"Ding B, Geng S, Hou X, Ma X, Xu H, Yang F, Liu K, Liang W, Ma G (2021) Berberine reduces renal cell pyroptosis in golden hamsters with diabetic nephropathy through the Nrf2-NLRP3-caspase-1-GSDMD pathway. Evid Based Complement Alternat Med 2021:5545193","journal-title":"Evid Based Complement Alternat Med"},{"key":"3461_CR16","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.7150\/ijbs.65476","volume":"18","author":"Y Dong","year":"2022","unstructured":"Dong Y, Fan H, Zhang Z, Jiang F, Li M, Zhou H, Guo W, Zhang Z, Kang Z, Gui Y, Shou Z, Li J, Zhu R, Fu Y, Sarapultsev A, Wang H, Luo S, Zhang G, Hu D (2022) Berberine ameliorates DSS-induced intestinal mucosal barrier dysfunction through microbiota-dependence and Wnt\/beta-catenin pathway. Int J Biol Sci 18:1381\u20131397","journal-title":"Int J Biol Sci"},{"key":"3461_CR17","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1007\/s10787-023-01178-0","volume":"31","author":"OY Elkhawaga","year":"2023","unstructured":"Elkhawaga OY, Ellety MM, Mofty SO, Ghanem MS, Mohamed AO (2023) Review of natural compounds for potential psoriasis treatment. Inflammopharmacology 31:1183\u20131198","journal-title":"Inflammopharmacology"},{"key":"3461_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109595","volume":"121","author":"Y Fang","year":"2020","unstructured":"Fang Y, Tian S, Pan Y, Li W, Wang Q, Tang Y, Yu T, Wu X, Shi Y, Ma P, Shu Y (2020) Pyroptosis: a new frontier in cancer. Biomed Pharmacother 121:109595","journal-title":"Biomed Pharmacother"},{"key":"3461_CR19","doi-asserted-by":"publisher","first-page":"931","DOI":"10.2217\/nnm-2018-0345","volume":"14","author":"MS Freag","year":"2019","unstructured":"Freag MS, Torky AS, Nasra MM, Abdelmonsif DA, Abdallah OY (2019) Liquid crystalline nanoreservoir releasing a highly skin-penetrating berberine oleate complex for psoriasis management. Nanomedicine (Lond) 14:931\u2013954","journal-title":"Nanomedicine (Lond)"},{"key":"3461_CR20","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s40659-020-00316-0","volume":"53","author":"J Gao","year":"2020","unstructured":"Gao J, Chen F, Fang H, Mi J, Qi Q, Yang M (2020) Daphnetin inhibits proliferation and inflammatory response in human HaCaT keratinocytes and ameliorates imiquimod-induced psoriasis-like skin lesion in mice. Biol Res 53:48","journal-title":"Biol Res"},{"key":"3461_CR21","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/S0140-6736(21)00184-7","volume":"397","author":"K Ghoreschi","year":"2021","unstructured":"Ghoreschi K, Balato A, Enerback C, Sabat R (2021) Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis. Lancet 397:754\u2013766","journal-title":"Lancet"},{"key":"3461_CR22","doi-asserted-by":"publisher","first-page":"17254","DOI":"10.1073\/pnas.1415756111","volume":"111","author":"B Guey","year":"2014","unstructured":"Guey B, Bodnar M, Manie SN, Tardivel A, Petrilli V (2014) Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function. Proc Natl Acad Sci U S A 111:17254\u201317259","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3461_CR23","doi-asserted-by":"publisher","first-page":"5263","DOI":"10.4049\/jimmunol.0902464","volume":"184","author":"K Guilloteau","year":"2010","unstructured":"Guilloteau K, Paris I, Pedretti N, Boniface K, Juchaux F, Huguier V, Guillet G, Bernard FX, Lecron JC, Morel F (2010) Skin inflammation induced by the synergistic action of IL-17A, IL-22, oncostatin M, IL-1alpha, and TNF-alpha recapitulates some features of psoriasis. J Immunol 184:5263\u20135270","journal-title":"J Immunol"},{"key":"3461_CR24","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/nm.3893","volume":"21","author":"H Guo","year":"2015","unstructured":"Guo H, Callaway JB, Ting JP (2015) Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med 21:677\u2013687","journal-title":"Nat Med"},{"key":"3461_CR25","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s12964-023-01041-3","volume":"21","author":"Y Guo","year":"2023","unstructured":"Guo Y, Zhang H, Lv Z, Du Y, Li D, Fang H, You J, Yu L, Li R (2023) Up-regulated CD38 by daphnetin alleviates lipopolysaccharide-induced lung injury via inhibiting MAPK\/NF-kappaB\/NLRP3 pathway. Cell Commun Signal 21:66","journal-title":"Cell Commun Signal"},{"key":"3461_CR26","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.biopha.2018.10.088","volume":"109","author":"EHM Hassanein","year":"2019","unstructured":"Hassanein EHM, Shalkami AS, Khalaf MM, Mohamed WR, Hemeida RAM (2019) The impact of Keap1\/Nrf2, P(38)MAPK\/NF-kappaB and Bax\/Bcl2\/caspase-3 signaling pathways in the protective effects of berberine against methotrexate-induced nephrotoxicity. Biomed Pharmacother 109:47\u201356","journal-title":"Biomed Pharmacother"},{"key":"3461_CR27","first-page":"655","volume":"39","author":"K Higuchi","year":"1987","unstructured":"Higuchi K (1987) Tubular damage in toxemia of pregnancy using urinary trehalase as a marker. Nihon Sanka Fujinka Gakkai Zasshi 39:655\u2013662","journal-title":"Nihon Sanka Fujinka Gakkai Zasshi"},{"key":"3461_CR28","first-page":"1394","volume":"33","author":"J Hu","year":"2013","unstructured":"Hu J, Yang R, Wen C, Li H, Zhao H (2013) Expression of NLRP3 inflammasome in BALB\/c mice with imiquimod-induced psoriasis-like inflammation and therapeutic effect of mustard seed (Sinapis Alba Linn). Nan Fang Yi Ke Da Xue Xue Bao 33:1394\u20131398","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"3461_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.165500","volume":"897","author":"S Huo","year":"2023","unstructured":"Huo S, Li B, Du J, Zhang X, Zhang J, Wang Q, Song M, Li Y (2023) Dibutyl phthalate induces liver fibrosis via p38MAPK\/NF-kappaB\/NLRP3-mediated pyroptosis. Sci Total Environ 897:165500","journal-title":"Sci Total Environ"},{"key":"3461_CR30","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1080\/15384101.2022.2100682","volume":"21","author":"F Izadparast","year":"2022","unstructured":"Izadparast F, Riahi-Zajani B, Yarmohammadi F, Hayes AW, Karimi G (2022) Protective effect of berberine against LPS-induced injury in the intestine: a review. Cell Cycle 21:2365\u20132378","journal-title":"Cell Cycle"},{"key":"3461_CR31","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1186\/s12967-023-04648-9","volume":"21","author":"Z Jiang","year":"2023","unstructured":"Jiang Z, Zeng Z, He H, Li M, Lan Y, Hui J, Bie P, Chen Y, Liu H, Fan H, Xia H (2023) Lycium barbarum glycopeptide alleviates neuroinflammation in spinal cord injury via modulating docosahexaenoic acid to inhibiting MAPKs\/NF-kB and pyroptosis pathways. J Transl Med 21:770","journal-title":"J Transl Med"},{"key":"3461_CR32","doi-asserted-by":"crossref","unstructured":"Johansen C, Funding AT, Otkjaer K, Kragballe K, Jensen UB, Madsen M, Binderup L, Skak-Nielsen T, Fjording MS, Iversen L (2006) Protein expression of TNF-alpha in psoriatic skin is regulated at a posttranscriptional level by MAPK-activated protein kinase 2. J Immunol 176: 1431-1438","DOI":"10.4049\/jimmunol.176.3.1431"},{"key":"3461_CR33","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.phymed.2007.09.011","volume":"15","author":"S Kim","year":"2008","unstructured":"Kim S, Kim Y, Kim JE, Cho KH, Chung JH (2008) Berberine inhibits TPA-induced MMP-9 and IL-6 expression in normal human keratinocytes. Phytomedicine 15:340\u2013347","journal-title":"Phytomedicine"},{"key":"3461_CR34","doi-asserted-by":"publisher","first-page":"95","DOI":"10.18632\/oncotarget.13921","volume":"8","author":"CG Li","year":"2017","unstructured":"Li CG, Yan L, Jing YY, Xu LH, Liang YD, Wei HX, Hu B, Pan H, Zha QB, Ouyang DY, He XH (2017) Berberine augments ATP-induced inflammasome activation in macrophages by enhancing AMPK signaling. Oncotarget 8:95\u2013109","journal-title":"Oncotarget"},{"key":"3461_CR35","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/s41419-020-2470-8","volume":"11","author":"H Li","year":"2020","unstructured":"Li H, Feng C, Fan C, Yang Y, Yang X, Lu H, Lu Q, Zhu F, Xiang C, Zhang Z, He P, Zuo J, Tang W (2020) Intervention of oncostatin M-driven mucosal inflammation by berberine exerts therapeutic property in chronic ulcerative colitis. Cell Death Dis 11:271","journal-title":"Cell Death Dis"},{"key":"3461_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154899","volume":"116","author":"C Li","year":"2023","unstructured":"Li C, Liu M, Deng L, Luo D, Ma R, Lu Q (2023) Oxyberberine ameliorates TNBS-induced colitis in rats through suppressing inflammation and oxidative stress via Keap1\/Nrf2\/NF-kappaB signaling pathways. Phytomedicine 116:154899","journal-title":"Phytomedicine"},{"key":"3461_CR37","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/s41419-023-06094-3","volume":"14","author":"N Lian","year":"2023","unstructured":"Lian N, Chen Y, Chen S, Zhang Y, Chen H, Yang Y, Gu H, Chen Q, Li M, Chen X (2023) Gasdermin D-mediated keratinocyte pyroptosis as a key step in psoriasis pathogenesis. Cell Death Dis 14:595","journal-title":"Cell Death Dis"},{"key":"3461_CR38","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.biopha.2016.02.015","volume":"79","author":"X Liu","year":"2016","unstructured":"Liu X, Zhang X, Ye L, Yuan H (2016) Protective mechanisms of berberine against experimental autoimmune myocarditis in a rat model. Biomed Pharmacother 79:222\u2013230","journal-title":"Biomed Pharmacother"},{"key":"3461_CR39","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.brainresbull.2017.08.008","volume":"134","author":"YM Liu","year":"2017","unstructured":"Liu YM, Niu L, Wang LL, Bai L, Fang XY, Li YC, Yi LT (2017) Berberine attenuates depressive-like behaviors by suppressing neuro-inflammation in stressed mice. Brain Res Bull 134:220\u2013227","journal-title":"Brain Res Bull"},{"key":"3461_CR40","doi-asserted-by":"crossref","unstructured":"Liu A, Zhao W, Zhang B, Tu Y, Wang Q, Li J (2020) Cimifugin ameliorates imiquimod-induced psoriasis by inhibiting oxidative stress and inflammation via NF-kappaB\/MAPK pathway. Biosci Rep 40","DOI":"10.1042\/BSR20200471"},{"key":"3461_CR41","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1146\/annurev-immunol-032713-120225","volume":"32","author":"MA Lowes","year":"2014","unstructured":"Lowes MA, Suarez-Farinas M, Krueger JG (2014) Immunology of psoriasis. Annu Rev Immunol 32:227\u2013255","journal-title":"Annu Rev Immunol"},{"key":"3461_CR42","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s00210-020-01914-1","volume":"394","author":"Z Lu","year":"2021","unstructured":"Lu Z, Lu F, Wu L, He B, Chen Z, Yan M (2021) Berberine attenuates non-alcoholic steatohepatitis by regulating chemerin\/CMKLR1 signalling pathway and Treg\/Th17 ratio. Naunyn Schmiedebergs Arch Pharmacol 394:383\u2013390","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"3461_CR43","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.1303","volume":"12","author":"J Ma","year":"2024","unstructured":"Ma J, Ji C, Sun Y, Liu D, Pan K, Wei Y (2024) Wogonin ameliorates the proliferation, inflammatory response, and pyroptosis in keratinocytes via NOD-like receptor family pyrin domain containing 3\/caspase-1\/gasdermin-D pathway. Immun Inflamm Dis 12:e1303","journal-title":"Immun Inflamm Dis"},{"key":"3461_CR44","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3389\/fphar.2020.00185","volume":"11","author":"W Mai","year":"2020","unstructured":"Mai W, Xu Y, Xu J, Zhao D, Ye L, Yu G, Wang Z, Lu Q, Lin J, Yang T, Gu C, Liu S, Zhong Y, Yang H (2020) Berberine inhibits nod-like receptor family pyrin domain containing 3 inflammasome activation and pyroptosis in nonalcoholic steatohepatitis via the ROS\/TXNIP Axis. Front Pharmacol 11:185","journal-title":"Front Pharmacol"},{"key":"3461_CR45","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.phymed.2018.04.051","volume":"47","author":"LTH Nguyen","year":"2018","unstructured":"Nguyen LTH, Ahn SH, Nguyen UT, Yang IJ (2018) Dang-Gui-Liu-Huang Tang a traditional herbal formula, ameliorates imiquimod-induced psoriasis-like skin inflammation in mice by inhibiting IL-22 production. Phytomedicine 47:48\u201357","journal-title":"Phytomedicine"},{"key":"3461_CR46","doi-asserted-by":"publisher","unstructured":"Nguyen LTH, Choi MJ, Shin HM, Yang IJ (2022) Coptisine alleviates imiquimod-induced psoriasis-like skin lesions and anxiety-like behavior in mice. Molecules 27. https:\/\/doi.org\/10.3390\/molecules27041412","DOI":"10.3390\/molecules27041412"},{"key":"3461_CR47","doi-asserted-by":"publisher","first-page":"3379","DOI":"10.31557\/APJCP.2022.23.10.3379","volume":"23","author":"S Obchoei","year":"2022","unstructured":"Obchoei S, Detarya M, Boonnate P, Saranaruk P, Vaeteewoottacharn K, Mahalapbutr P, Okada S, Wongkham S (2022) Low dose berberine suppresses cholangiocarcinoma cell progression as a multi-kinase inhibitor. Asian Pac J Cancer Prev 23:3379\u20133386","journal-title":"Asian Pac J Cancer Prev"},{"key":"3461_CR48","doi-asserted-by":"publisher","first-page":"2421","DOI":"10.4049\/jimmunol.1600035","volume":"197","author":"MJ Primiano","year":"2016","unstructured":"Primiano MJ, Lefker BA, Bowman MR, Bree AG, Hubeau C, Bonin PD, Mangan M, Dower K, Monks BG, Cushing L, Wang S, Guzova J, Jiao A, Lin LL, Latz E, Hepworth D, Hall JP (2016) Efficacy and pharmacology of the NLRP3 inflammasome inhibitor CP-456,773 (CRID3) in murine models of dermal and pulmonary inflammation. J Immunol 197:2421\u20132433","journal-title":"J Immunol"},{"key":"3461_CR49","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s12974-023-02744-7","volume":"20","author":"Z Qin","year":"2023","unstructured":"Qin Z, Shi DD, Li W, Cheng D, Zhang YD, Zhang S, Tsoi B, Zhao J, Wang Z, Zhang ZJ (2023) Berberine ameliorates depression-like behaviors in mice via inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing neuroplasticity disruption. J Neuroinflammation 20:54","journal-title":"J Neuroinflammation"},{"key":"3461_CR50","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.3390\/ijms20061475","volume":"20","author":"A Rendon","year":"2019","unstructured":"Rendon A, Schakel K (2019) Psoriasis pathogenesis and treatment. Int J Mol Sci 20:1475","journal-title":"Int J Mol Sci"},{"key":"3461_CR51","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.3390\/genes11101155","volume":"11","author":"G Rioux","year":"2020","unstructured":"Rioux G, Ridha Z, Simard M, Turgeon F, Guerin SL, Pouliot R (2020) Transcriptome profiling analyses in psoriasis: a dynamic contribution of keratinocytes to the pathogenesis. Genes (Basel) 11:1155","journal-title":"Genes (Basel)"},{"key":"3461_CR52","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.tig.2010.06.006","volume":"26","author":"ED Roberson","year":"2010","unstructured":"Roberson ED, Bowcock AM (2010) Psoriasis genetics: breaking the barrier. Trends Genet 26:415\u2013423","journal-title":"Trends Genet"},{"key":"3461_CR53","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/j.jaci.2019.06.019","volume":"144","author":"K Sakurai","year":"2019","unstructured":"Sakurai K, Dainichi T, Garcet S, Tsuchiya S, Yamamoto Y, Kitoh A, Honda T, Nomura T, Egawa G, Otsuka A, Nakajima S, Matsumoto R, Nakano Y, Otsuka M, Iwakura Y, Grinberg-Bleyer Y, Ghosh S, Sugimoto Y, Guttman-Yassky E, Krueger JG, Kabashima K (2019) Cutaneous p38 mitogen-activated protein kinase activation triggers psoriatic dermatitis. J Allergy Clin Immunol 144:1036\u20131049","journal-title":"J Allergy Clin Immunol"},{"key":"3461_CR54","doi-asserted-by":"publisher","first-page":"6238","DOI":"10.3390\/molecules26206238","volume":"26","author":"P Sarbadhikary","year":"2021","unstructured":"Sarbadhikary P, George BP, Abrahamse H (2021) Inhibitory role of berberine, an isoquinoline alkaloid, on NLRP3 inflammasome activation for the treatment of inflammatory diseases. Molecules 26:6238","journal-title":"Molecules"},{"key":"3461_CR55","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","volume":"140","author":"K Schroder","year":"2010","unstructured":"Schroder K, Tschopp J (2010) The inflammasomes. Cell 140:821\u2013832","journal-title":"Cell"},{"key":"3461_CR56","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/s41419-021-04284-5","volume":"12","author":"Y Shou","year":"2021","unstructured":"Shou Y, Yang L, Yang Y, Xu J (2021) Inhibition of keratinocyte ferroptosis suppresses psoriatic inflammation. Cell Death Dis 12:1009","journal-title":"Cell Death Dis"},{"key":"3461_CR57","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/s41419-019-1510-8","volume":"10","author":"S Sun","year":"2019","unstructured":"Sun S, Zhang X, Xu M, Zhang F, Tian F, Cui J, Xia Y, Liang C, Zhou S, Wei H, Zhao H, Wu G, Xu B, Liu X, Yang G, Wang Q, Zhang L, Gong Y, Shao C, Zou Y (2019) Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytes. Cell Death Dis 10:274","journal-title":"Cell Death Dis"},{"key":"3461_CR58","doi-asserted-by":"publisher","first-page":"519","DOI":"10.3390\/molecules21040519","volume":"21","author":"MS Tsang","year":"2016","unstructured":"Tsang MS, Jiao D, Chan BC, Hon KL, Leung PC, Lau CB, Wong EC, Cheng L, Chan CK, Lam CW, Wong CK (2016) Anti-inflammatory activities of pentaherbs formula, berberine, gallic acid and chlorogenic acid in atopic dermatitis-like skin inflammation. Molecules 21:519","journal-title":"Molecules"},{"key":"3461_CR59","doi-asserted-by":"publisher","first-page":"5836","DOI":"10.4049\/jimmunol.0802999","volume":"182","author":"L van der Fits","year":"2009","unstructured":"van der Fits L, Mourits S, Voerman JS, Kant M, Boon L, Laman JD, Cornelissen F, Mus AM, Florencia E, Prens EP, Lubberts E (2009) Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23\/IL-17 axis. J Immunol 182:5836\u20135845","journal-title":"J Immunol"},{"key":"3461_CR60","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.jdermsci.2020.03.001","volume":"98","author":"D Wang","year":"2020","unstructured":"Wang D, Duncan B, Li X, Shi J (2020) The role of NLRP3 inflammasome in infection-related, immune-mediated and autoimmune skin diseases. J Dermatol Sci 98:146\u2013151","journal-title":"J Dermatol Sci"},{"key":"3461_CR61","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1002\/jcp.30587","volume":"237","author":"M Wang","year":"2022","unstructured":"Wang M, Wang Y, Zhang M, Duan Q, Chen C, Sun Q, Liu M, Zheng Y, Shao Y (2022) Kynureninase contributes to the pathogenesis of psoriasis through pro-inflammatory effect. J Cell Physiol 237:1044\u20131056","journal-title":"J Cell Physiol"},{"key":"3461_CR62","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154083","volume":"100","author":"X Wei","year":"2022","unstructured":"Wei X, Zhang B, Wei F, Ding M, Luo Z, Han X, Tan X (2022) Gegen Qinlian pills alleviate carrageenan-induced thrombosis in mice model by regulating the HMGB1\/NF-kappaB\/NLRP3 signaling. Phytomedicine 100:154083","journal-title":"Phytomedicine"},{"key":"3461_CR63","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.818173","volume":"13","author":"H Wu","year":"2022","unstructured":"Wu H, Zeng L, Ou J, Wang T, Chen Y, Nandakumar KS (2022) Estrogen acts through estrogen receptor-beta to promote mannan-induced psoriasis-like skin inflammation. Front Immunol 13:818173","journal-title":"Front Immunol"},{"key":"3461_CR64","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155075","volume":"121","author":"D Wu","year":"2023","unstructured":"Wu D, Wang P, Zhao C, Su J, Zhang J, Ma W, Zhang Y, Xu H (2023) Levo-tetrahydropalmatine ameliorates neuropathic pain by inhibiting the activation of the Clec7a-MAPK\/NF-kappaB-NLRP3 inflammasome axis. Phytomedicine 121:155075","journal-title":"Phytomedicine"},{"key":"3461_CR65","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1007\/s11418-022-01664-9","volume":"77","author":"Y Xiong","year":"2023","unstructured":"Xiong Y, Wang J, Wang S, Li H, Zhou X (2023) Tryptanthrin ameliorates imiquimod-induced psoriasis in mice by suppressing inflammation and oxidative stress via NF-kappaB\/MAPK\/Nrf2 pathways. J Nat Med 77:188\u2013201","journal-title":"J Nat Med"},{"key":"3461_CR66","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3892\/ijmm.2023.5252","volume":"51","author":"L Yang","year":"2023","unstructured":"Yang L, Cheng CF, Li ZF, Huang XJ, Cai SQ, Ye SY, Zhao LJ, Xiong Y, Chen DF, Liu HL, Ren ZX, Fang HC (2023) Berberine blocks inflammasome activation and alleviates diabetic cardiomyopathy via the miR-18a-3p\/Gsdmd pathway. Int J Mol Med 51:49","journal-title":"Int J Mol Med"},{"key":"3461_CR67","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1007\/s11427-013-4568-z","volume":"58","author":"J Yao","year":"2015","unstructured":"Yao J, Kong W, Jiang J (2015) Learning from berberine: treating chronic diseases through multiple targets. Sci China Life Sci 58:854\u2013859","journal-title":"Sci China Life Sci"},{"key":"3461_CR68","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s00403-005-0602-8","volume":"297","author":"AC Yazici","year":"2005","unstructured":"Yazici AC, Tursen U, Apa DD, Ikizoglu G, Api H, Baz K, Tasdelen B (2005) The changes in expression of ICAM-3, Ki-67, PCNA, and CD31 in psoriatic lesions before and after methotrexate treatment. Arch Dermatol Res 297:249\u2013255","journal-title":"Arch Dermatol Res"},{"key":"3461_CR69","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/s41392-021-00507-5","volume":"6","author":"P Yu","year":"2021","unstructured":"Yu P, Zhang X, Liu N, Tang L, Peng C, Chen X (2021) Pyroptosis: mechanisms and diseases. Signal Transduct Target Ther 6:128","journal-title":"Signal Transduct Target Ther"},{"key":"3461_CR70","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2023.149411","volume":"695","author":"H Yu","year":"2024","unstructured":"Yu H, Zhang S, Li R, Ma C, Zhang Q, Xia F, Zhou B, Xie Z, Liao Z (2024) Berberine alleviates inflammation and suppresses PLA2-COX-2-PGE2-EP2 pathway through targeting gut microbiota in DSS-induced ulcerative colitis. Biochem Biophys Res Commun 695:149411","journal-title":"Biochem Biophys Res Commun"},{"key":"3461_CR71","doi-asserted-by":"publisher","first-page":"2786","DOI":"10.1111\/febs.14147","volume":"284","author":"M Yue","year":"2017","unstructured":"Yue M, Xia Y, Shi C, Guan C, Li Y, Liu R, Wei Z, Dai Y (2017) Berberine ameliorates collagen-induced arthritis in rats by suppressing Th17 cell responses via inducing cortistatin in the gut. FEBS J 284:2786\u20132801","journal-title":"FEBS J"},{"key":"3461_CR72","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1111\/bph.15983","volume":"180","author":"L Zhang","year":"2023","unstructured":"Zhang L, Ma X, Shi R, Zhang L, Zhao R, Duan R, Qin Y, Gao S, Li X, Duan J, Li J (2023) Allicin ameliorates imiquimod-induced psoriasis-like skin inflammation via disturbing the interaction of keratinocytes with IL-17A. Br J Pharmacol 180:628\u2013646","journal-title":"Br J Pharmacol"},{"key":"3461_CR73","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.7150\/ijbs.34211","volume":"15","author":"W Zhao","year":"2019","unstructured":"Zhao W, Ma L, Cai C, Gong X (2019) Caffeine inhibits NLRP3 inflammasome activation by suppressing MAPK\/NF-kappaB and A2aR signaling in LPS-induced THP-1 macrophages. Int J Biol Sci 15:1571\u20131581","journal-title":"Int J Biol Sci"},{"key":"3461_CR74","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.brainresbull.2021.09.005","volume":"177","author":"Y Zhao","year":"2021","unstructured":"Zhao Y, Li Z, Lu E, Sheng Q, Zhao Y (2021) Berberine exerts neuroprotective activities against cerebral ischemia\/reperfusion injury through up-regulating PPAR-gamma to suppress NF-kappaB-mediated pyroptosis. Brain Res Bull 177:22\u201330","journal-title":"Brain Res Bull"},{"key":"3461_CR75","doi-asserted-by":"publisher","first-page":"7392","DOI":"10.1080\/21655979.2022.2047405","volume":"13","author":"X Zhao","year":"2022","unstructured":"Zhao X, Cui D, Yuan W, Chen C, Liu Q (2022) Berberine represses Wnt\/beta-catenin pathway activation via modulating the microRNA-103a-3p\/Bromodomain-containing protein 4 axis, thereby refraining pyroptosis and reducing the intestinal mucosal barrier defect induced via colitis. Bioengineered 13:7392\u20137409","journal-title":"Bioengineered"},{"key":"3461_CR76","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.176253","volume":"964","author":"C Zhong","year":"2024","unstructured":"Zhong C, Xie Y, Wang H, Chen W, Yang Z, Zhang L, Deng Q, Cheng T, Li M, Ju J, Liu Y, Liang H (2024) Berberine inhibits NLRP3 inflammasome activation by regulating mTOR\/mtROS axis to alleviate diabetic cardiomyopathy. Eur J Pharmacol 964:176253","journal-title":"Eur J Pharmacol"},{"key":"3461_CR77","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/s41419-022-04523-3","volume":"13","author":"X Zhou","year":"2022","unstructured":"Zhou X, Chen Y, Cui L, Shi Y, Guo C (2022) Advances in the pathogenesis of psoriasis: from keratinocyte perspective. Cell Death Dis 13:81","journal-title":"Cell Death Dis"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03461-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-024-03461-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03461-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T13:24:01Z","timestamp":1744205041000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-024-03461-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,4]]},"references-count":77,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["3461"],"URL":"https:\/\/doi.org\/10.1007\/s00210-024-03461-5","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,4]]},"assertion":[{"value":"15 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments in this study were reviewed and approved by the Animal Ethics Committee of The Second Affiliated Hospital of Shandong First Medical University. Great efforts were made to minimize the number of animals and to reduce their suffering.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}