{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:53:13Z","timestamp":1791841993957,"version":"4.3.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2021\/14414-8"],"award-info":[{"award-number":["2021\/14414-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2022\/07737-8"],"award-info":[{"award-number":["2022\/07737-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/15175-1"],"award-info":[{"award-number":["2017\/15175-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/16805-4"],"award-info":[{"award-number":["2019\/16805-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["303839\/2019-8"],"award-info":[{"award-number":["303839\/2019-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s00210-024-03463-3","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T07:02:15Z","timestamp":1728457335000},"page":"3965-3976","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The negative chronotropic effects of (\u00b1)-propranolol and (\u00b1)-4-NO2-propranolol in the rat isolated right atrium are due to blockade of the 6-nitrodopamine receptor"],"prefix":"10.1007","volume":"398","author":[{"given":"Denis Lima","family":"Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius Francisco","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Britto-J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Fuguhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Frecentese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Sparaco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Santagada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Caliendo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Sampaio","family":"Pupo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edson","family":"Antunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto","family":"De Nucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"3463_CR1","unstructured":"Andersen ML (2016) Guia brasileiro de produ\u00e7\u00e3o, manuten\u00e7\u00e3o ou utiliza\u00e7\u00e3o de animais em atividade de ensino ou pesquisa cientifica, Conselho nacional de controle de experimenta\u00e7\u00e3o animal. Bras\u00edlia: Minist\u00e9rio da Ci\u00eancia, Tecnologia e Inova\u00e7\u00e3o. 11.794\/2008, art 22, inciso II"},{"issue":"307","key":"3463_CR2","doi-asserted-by":"publisher","first-page":"120879","DOI":"10.1016\/j.lfs.2022.120879","volume":"15","author":"J Britto-J\u00fanior","year":"2022","unstructured":"Britto-J\u00fanior J, de Oliveira MG, Dos Reis Gati C, Campos R, Moraes MO, Moraes MEA, M\u00f3nica FZ, Antunes E, De Nucci G (2022) 6-NitroDopamine is an endogenous modulator of rat heart chronotropism. Life Sci 15(307):120879. https:\/\/doi.org\/10.1016\/j.lfs.2022.120879","journal-title":"Life Sci"},{"issue":"138\u2013139","key":"3463_CR3","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.niox.2023.06.001","volume":"1","author":"J Britto-J\u00fanior","year":"2023","unstructured":"Britto-J\u00fanior J, Pereira do Prado GL, Chiavegatto S, Cunha F, Moraes O, Moraes E, Monica FZ, Antunes E, De Nucci G (2023a) The importance of the endothelial nitric oxide synthase on the release of 6-nitrodopamine from mouse isolated atria and ventricles and their role on chronotropism. Nitric Oxide 1(138\u2013139):26\u201333. https:\/\/doi.org\/10.1016\/j.niox.2023.06.001","journal-title":"Nitric Oxide"},{"key":"3463_CR4","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1007\/s00210-023-02394-9","volume":"396","author":"J Britto-J\u00fanior","year":"2023","unstructured":"Britto-J\u00fanior J, Lima AT, Fuguhara V, Monica FZ, Antunes E, De Nucci G (2023b) Investigation on the positive chronotropic action of 6-nitrodopamine in the rat isolated atria. Naunyn Schmiedebergs Arch Pharmacol 396:1279\u20131290. https:\/\/doi.org\/10.1007\/s00210-023-02394-9","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"13","key":"3463_CR5","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.3390\/life13102012","volume":"4","author":"J Britto-J\u00fanior","year":"2023","unstructured":"Britto-J\u00fanior J, Medeiros-Teixeira LR, Lima AT, Dassow LC, Lopes-Martins R\u00c1B, Campos R, Moraes MO, Moraes MEA, Antunes E, De Nucci G (2023c) 6-Nitrodopamine is the most potent endogenous positive inotropic agent in the isolated rat heart. Life (Basel) 4(13):2012. https:\/\/doi.org\/10.3390\/life13102012","journal-title":"Life (Basel)"},{"key":"3463_CR6","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1093\/eurheartj\/12.suppl_f.54","volume":"12","author":"OE Brodde","year":"1991","unstructured":"Brodde OE (1991) Pathophysiology of the beta-adrenoceptor system in chronic heart failure: consequences for treatment with agonists, partial agonists or antagonists? Eur Heart J 12:54\u201362. https:\/\/doi.org\/10.1093\/eurheartj\/12.suppl_f.54","journal-title":"Eur Heart J"},{"issue":"346","key":"3463_CR7","doi-asserted-by":"publisher","first-page":"f55","DOI":"10.1136\/bmj.f55.Erratum.In:BMJ.2013;346:f596","volume":"16","author":"S Chatterjee","year":"2013","unstructured":"Chatterjee S, Biondi-Zoccai G, Abbate A, D\u2019Ascenzo F, Castagno D, Van Tassell B, Mukherjee D, Lichstein E (2013) Benefits of \u03b2 blockers in patients with heart failure and reduced ejection fraction: network meta-analysis. BMJ 16(346):f55. https:\/\/doi.org\/10.1136\/bmj.f55.Erratum.In:BMJ.2013;346:f596","journal-title":"BMJ"},{"issue":"3","key":"3463_CR8","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1136\/bmj.3.5725.731","volume":"26","author":"DJ Coltart","year":"1970","unstructured":"Coltart DJ, Shand DG (1970) Plasma propranolol levels in the quantitative assessment of beta-adrenergic blockade in man. Br Med J 26(3):731\u2013734. https:\/\/doi.org\/10.1136\/bmj.3.5725.731","journal-title":"Br Med J"},{"issue":"37","key":"3463_CR9","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1136\/hrt.37.4.357","volume":"1","author":"J Coltart","year":"1975","unstructured":"Coltart J, Alderman EL, Robison SC, Harrison DC (1975) Effect of propranolol on left ventricular function, segmental wall motion, and diastolic pressure-volume relation in man. Br Heart J 1(37):357\u2013364. https:\/\/doi.org\/10.1136\/hrt.37.4.357","journal-title":"Br Heart J"},{"issue":"2","key":"3463_CR10","first-page":"58","volume":"14","author":"SP Desai","year":"1989","unstructured":"Desai SP, Marsh JD, Allen PD (1989) Contractility effects of local anesthetics in the presence of sodium channel blockade. Reg Anesth 14(2):58\u201362","journal-title":"Reg Anesth"},{"key":"3463_CR11","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1111\/j.1751-7176.2011.00515.x","volume":"13","author":"WH Frishman","year":"2011","unstructured":"Frishman WH, Saunders E (2011) \u03b2-Adrenergic blockers. J Clin Hypertens 13:649\u2013653. https:\/\/doi.org\/10.1111\/j.1751-7176.2011.00515.x","journal-title":"J Clin Hypertens"},{"issue":"4","key":"3463_CR12","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1161\/01.cir.73.4.615","volume":"73","author":"GJ Hasking","year":"1986","unstructured":"Hasking GJ, Esler MD, Jennings GL, Burton D, Johns JA, Korner PI (1986) Norepinephrine spillover to plasma in patients with congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity. Circulation 73(4):615\u2013621. https:\/\/doi.org\/10.1161\/01.cir.73.4.615","journal-title":"Circulation"},{"issue":"32","key":"3463_CR13","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1254\/jjp.32.221","volume":"1","author":"A Hirano","year":"1982","unstructured":"Hirano A, Hashimoto H, Nakashima M (1982) Influence of hypothyroid status on dopamine-induced positive chronotropic and inotropic effects on isolated rat atria. Japan J Pharmacol 1(32):221\u2013230. https:\/\/doi.org\/10.1254\/jjp.32.221","journal-title":"Japan J Pharmacol"},{"issue":"20","key":"3463_CR14","doi-asserted-by":"publisher","first-page":"11584","DOI":"10.1073\/pnas.95.20.11584","volume":"95","author":"Y Kamisaki","year":"1998","unstructured":"Kamisaki Y, Wada K, Bian K, Balabanli B, Davis K, Martin E, Behbod F, Lee YC, Murad F (1998) An activity in rat tissues that modifies nitrotyrosine-containing proteins. Proc Natl Acad Sci U S A 95(20):11584\u201311589. https:\/\/doi.org\/10.1073\/pnas.95.20.11584","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3463_CR15","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1161\/01.cir.77.1.162","volume":"77","author":"T Kavanagh","year":"1988","unstructured":"Kavanagh T, Yacoub MH, Mertens DJ, Kennedy J, Campbell RB, Sawyer P (1988) Cardiorespiratory responses to exercise training after orthotopic cardiac transplantation. Circulation 77:162\u2013171. https:\/\/doi.org\/10.1161\/01.cir.77.1.162","journal-title":"Circulation"},{"key":"3463_CR16","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/0014-2999(82)90398-3","volume":"86","author":"MJ Lewis","year":"1983","unstructured":"Lewis MJ, Grey AC, Henderson AH (1983) Inotropic \u03b2-blocking potency (pA2) and partial agonist activity of propranolol, practolol, sotalol and acebutolol. Eur J Pharmacol 86:71\u201376","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"3463_CR17","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1590\/s0066-782x2010005000062","volume":"95","author":"F Marques","year":"2010","unstructured":"Marques F, Castro RB, Nobre F, Pintya AO, Gallo L Jr, Maciel BC, Sim\u00f5es MV (2010) Replacement of carvedilol for propranolol in patients with heart failure. Arq Bras Cardiol 95(1):107\u2013114. https:\/\/doi.org\/10.1590\/s0066-782x2010005000062","journal-title":"Arq Bras Cardiol"},{"issue":"31","key":"3463_CR18","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1016\/0006-2952(82)90668-2","volume":"1","author":"JC Matthews","year":"1982","unstructured":"Matthews JC, Baker JK (1982) Effects of propranolol and a number of its analogues on sodium channels. Biochem Pharmacol 1(31):1681\u20131685. https:\/\/doi.org\/10.1016\/0006-2952(82)90668-2","journal-title":"Biochem Pharmacol"},{"key":"3463_CR19","first-page":"185","volume":"4","author":"R Mehvar","year":"2001","unstructured":"Mehvar R, Brocks DR (2001) Stereospecific pharmacokinetics and pharmacodynamics of beta-adrenergic blockers in humans. J Pharm Pharm Sci 4:185\u2013200","journal-title":"J Pharm Pharm Sci"},{"key":"3463_CR20","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1124\/mol.119.118927","volume":"97","author":"MC Michel","year":"2020","unstructured":"Michel MC, Murphy TJ, Motulsky HJ (2020) New author guidelines for displaying data and reporting data analysis and statistical methods in experimental biology. Mol Pharmacol 97:49\u201360. https:\/\/doi.org\/10.1124\/mol.119.118927","journal-title":"Mol Pharmacol"},{"key":"3463_CR21","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1007\/s00210-014-1037-6","volume":"387","author":"HJ Motulsky","year":"2014","unstructured":"Motulsky HJ (2014) Common misconceptions about data analysis and statistics. Naunyn Schmiedebergs Arch Pharmacol 387:1017\u20131023. https:\/\/doi.org\/10.1007\/s00210-014-1037-6","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"3463_CR22","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/BF00501381","volume":"308","author":"SR O'Donnell","year":"1979","unstructured":"O\u2019Donnell SR, Wanstall JC (1979) The importance of choice of agonist in studies designed to predict beta 2: beta 1 adrenoceptor selectivity of antagonists from pA2 values on guinea-pig trachea and atria. Naunyn Schmiedebergs Arch Pharmacol 308:183\u2013190. https:\/\/doi.org\/10.1007\/BF00501381","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"18","key":"3463_CR23","doi-asserted-by":"publisher","first-page":"e3000410","DOI":"10.1371\/journal.pbio.3000410","volume":"14","author":"N Percie du Sert","year":"2020","unstructured":"Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M, Garner P, Holgate ST, Howells DW, Karp NA, Lazic SE, Lidster K, MacCallum CJ, Macleod M, Pearl EJ, Petersen OH, Rawle F, Reynolds P, Rooney K, Sena ES, Silberberg SD, Steckler T, W\u00fcrbel H (2020) The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. PLoS Biol 14(18):e3000410. https:\/\/doi.org\/10.1371\/journal.pbio.3000410","journal-title":"PLoS Biol"},{"key":"3463_CR24","doi-asserted-by":"publisher","first-page":"e5691","DOI":"10.1002\/bmc.5691","volume":"37","author":"GQ Quirino-Junior","year":"2023","unstructured":"Quirino-Junior GQ, Britto-J\u00fanior J, Magalhaes TB, Campos R, Nyamkondiwa KL, Klugh KL, Peterson LW, Corvino A, Sparaco R, Frecentese F, Caliendo G, De Nucci G (2023) Measurement of 6-cyanodopamine, 6-nitrodopa, 6-nitrodopamine and 6-nitroadrenaline by LC-MS\/MS in Krebs-Henseleit solution. Assessment of basal release from rabbit isolated right atrium and ventricles. Biomed Chromatogr 37:e5691. https:\/\/doi.org\/10.1002\/bmc.5691","journal-title":"Biomed Chromatogr"},{"issue":"1","key":"3463_CR25","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3390\/molecules28010057","volume":"28","author":"R Sparaco","year":"2023","unstructured":"Sparaco R, Scognamiglio A, Corvino A, Caliendo G, Fiorino F, Magli E, Perissutti E, Santagada V, Severino B, Luciano P, Caserta M, Aiello A, De Nucci G, Frecentese F (2023) Synthesis, Chiral resolution and enantiomers absolute configuration of 4-nitropropranolol and 7-nitropropranolol. Molecules 28(1):57. https:\/\/doi.org\/10.3390\/molecules28010057","journal-title":"Molecules"},{"issue":"5","key":"3463_CR26","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/s1388-9842(03)00109-0","volume":"5","author":"P Venugopalan","year":"2003","unstructured":"Venugopalan P, Agarwal AK (2003) Plasma catecholamine levels parallel severity of heart failure and have prognostic value in children with dilated cardiomyopathy. Eur J Heart Fail 5(5):655\u2013658. https:\/\/doi.org\/10.1016\/s1388-9842(03)00109-0","journal-title":"Eur J Heart Fail"},{"issue":"1","key":"3463_CR27","doi-asserted-by":"publisher","first-page":"144","DOI":"10.3389\/fphar.2010.00144.PMID:21833183","volume":"31","author":"DW Wang","year":"2010","unstructured":"Wang DW, Mistry AM, Kahlig KM, Kearney JA, Xiang J, George AL Jr (2010) Propranolol blocks cardiac and neuronal voltage-gated sodium channels. Front Pharmacol 31(1):144. https:\/\/doi.org\/10.3389\/fphar.2010.00144.PMID:21833183","journal-title":"Front Pharmacol"},{"key":"3463_CR28","doi-asserted-by":"publisher","first-page":"3641","DOI":"10.1021\/jo00413a002","volume":"43","author":"WL Welson","year":"1978","unstructured":"Welson WL, Burke TR (1978) Absolute configuration of glycerol derivatives. 5. Oxprenolol enantiomers. J Org Chem 43:3641\u20133645. https:\/\/doi.org\/10.1021\/jo00413a002","journal-title":"J Org Chem"},{"issue":"8","key":"3463_CR29","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1111\/j.1651-2227.1996.tb14187.x","volume":"85","author":"JR Wu","year":"1996","unstructured":"Wu JR, Chang HR, Chen SS, Huang TY (1996) Circulating noradrenaline and beta-adrenergic receptors in children with congestive heart failure. Acta Paediatr 85(8):923\u2013927. https:\/\/doi.org\/10.1111\/j.1651-2227.1996.tb14187.x","journal-title":"Acta Paediatr"},{"key":"3463_CR30","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1152\/physiol.00020.2023","volume":"39","author":"R Zatz","year":"2024","unstructured":"Zatz R, De Nucci G (2024) Endothelium-derived dopamine and 6-nitrodopamine in the cardiovascular system. Physiology 39:44\u201359. https:\/\/doi.org\/10.1152\/physiol.00020.2023","journal-title":"Physiology"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03463-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-024-03463-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03463-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T22:04:07Z","timestamp":1744149847000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-024-03463-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,9]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["3463"],"URL":"https:\/\/doi.org\/10.1007\/s00210-024-03463-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4680045\/v1","asserted-by":"object"}]},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,9]]},"assertion":[{"value":"3 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental protocols were authorized by the Ethics Committee in Animal Use of UNICAMP (CEUA\/UNICAMP, protocol number 5942\u20131\/2022).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors authorize the submission and publication of this article Naunyn\u2013Schmiedeberg\u2019s Archives of Pharmacology.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}