{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:43:01Z","timestamp":1784014981439,"version":"3.55.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T00:00:00Z","timestamp":1727481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T00:00:00Z","timestamp":1727481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1007\/s00210-024-03470-4","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T03:45:58Z","timestamp":1727495158000},"page":"3049-3065","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Determination of beneficial effects of cuminaldehyde on hyperglycemia\u00a0associated kidney malfunctions"],"prefix":"10.1007","volume":"398","author":[{"given":"Abhishek Kumar","family":"Das","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parames C.","family":"Sil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,28]]},"reference":[{"key":"3470_CR1","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1111\/jphp.13112","volume":"71","author":"M Adu-Frimpong","year":"2019","unstructured":"Adu-Frimpong M, Qiuyu W, Firempong CK, Mukhtar YM, Yang Q, Omari-Siaw E, Lijun Z, Xu X, Yu J (2019) Novel cuminaldehyde self-emulsified nanoemulsion for enhanced antihepatotoxicity in carbon tetrachloride-treated mice. J Pharm Pharmacol 71:1324\u20131338","journal-title":"J Pharm Pharmacol"},{"key":"3470_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/360438","volume":"2014","author":"A Ayala","year":"2014","unstructured":"Ayala A, Mu\u00f1oz MF, Arg\u00fcelles S (2014) Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev 2014:1","journal-title":"Oxid Med Cell Longev"},{"key":"3470_CR3","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.fct.2019.02.021","volume":"126","author":"M-F Chen","year":"2019","unstructured":"Chen M-F, Liou S-S, Kao S-T, Liu I-M (2019) Erianin protects against high glucose-induced oxidative injury in renal tubular epithelial cells. Food Chem Toxicol 126:97\u2013105","journal-title":"Food Chem Toxicol"},{"key":"3470_CR4","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3389\/fphar.2019.00027","volume":"10","author":"S Chowdhury","year":"2019","unstructured":"Chowdhury S, Ghosh S, Das AK, Sil PC (2019) Ferulic acid protects hyperglycemia-induced kidney damage by regulating oxidative insult, inflammation and autophagy. Front Pharmacol 10:27","journal-title":"Front Pharmacol"},{"key":"3470_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120769","volume":"305","author":"AK Das","year":"2022","unstructured":"Das AK, Hossain U, Ghosh S, Biswas S, Mandal M, Mandal B, Brahmachari G, Bagchi A, Sil PC (2022b) Amelioration of oxidative stress mediated inflammation and apoptosis in pancreatic islets by Lupeol in STZ-induced hyperglycaemic mice. Life Sci 305:120769","journal-title":"Life Sci"},{"key":"3470_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115367","volume":"207","author":"AK Das","year":"2023","unstructured":"Das AK, Ghosh N, Mandal A, Sil PC (2023) Glycobiology of cellular expiry: decrypting the role of glycan-lectin regulatory complex and therapeutic strategies focusing on cancer. Biochem Pharmacol 207:115367","journal-title":"Biochem Pharmacol"},{"key":"3470_CR7","doi-asserted-by":"crossref","unstructured":"Das AK, Ghosh S, Sil PC (2022a) Vitamin K. Antioxidants effects in health. Elsevier, pp 561\u2013582","DOI":"10.1016\/B978-0-12-819096-8.00067-7"},{"key":"3470_CR8","doi-asserted-by":"publisher","first-page":"24","DOI":"10.31083\/j.fbe1404024","volume":"14","author":"K Duraisamy","year":"2022","unstructured":"Duraisamy K, Leelavinothan P, Ellappan P, Balaji TDS, Rajagopal P, Jayaraman S, Babu S (2022) Cuminaldehyde ameliorates hyperglycemia in diabetic mice. Frontiers in Bioscience-Elite 14:24","journal-title":"Frontiers in Bioscience-Elite"},{"key":"3470_CR9","doi-asserted-by":"publisher","first-page":"393","DOI":"10.4239\/wjd.v5.i3.393","volume":"5","author":"MB Duran-Salgado","year":"2014","unstructured":"Duran-Salgado MB, Rubio-Guerra AF (2014) Diabetic nephropathy and inflammation. World J Diabetes 5:393","journal-title":"World J Diabetes"},{"key":"3470_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.19080\/JPCR.2017.02.555585","volume":"2","author":"ME Ebada","year":"2017","unstructured":"Ebada ME (2017) Cuminaldehyde: a potential drug candidate. J Pharmacol Clin Res 2:1\u20134","journal-title":"J Pharmacol Clin Res"},{"key":"3470_CR11","doi-asserted-by":"crossref","unstructured":"Floh\u00e9 L, G\u00fcnzler WA (1984) [12] Assays of glutathione peroxidase. Methods in enzymology. Elsevier, pp 114\u2013120","DOI":"10.1016\/S0076-6879(84)05015-1"},{"key":"3470_CR12","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.78","volume":"1","author":"BL Furman","year":"2021","unstructured":"Furman BL (2021) Streptozotocin-induced diabetic models in mice and rats. Current Protocols 1:e78","journal-title":"Current Protocols"},{"key":"3470_CR13","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1007\/s10068-018-0506-y","volume":"28","author":"G Ghasemi","year":"2019","unstructured":"Ghasemi G, Fattahi M, Alirezalu A, Ghosta Y (2019) Antioxidant and antifungal activities of a new chemovar of cumin (Cuminum cyminum L.). Food Sci Biotechnol 28:669\u2013677","journal-title":"Food Sci Biotechnol"},{"key":"3470_CR14","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.fct.2018.05.029","volume":"118","author":"S Ghosh","year":"2018","unstructured":"Ghosh S, Chowdhury S, Sarkar P, Sil PC (2018) Ameliorative role of ferulic acid against diabetes associated oxidative stress induced spleen damage. Food Chem Toxicol 118:272\u2013286","journal-title":"Food Chem Toxicol"},{"key":"3470_CR15","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.fct.2018.11.055","volume":"124","author":"S Ghosh","year":"2019","unstructured":"Ghosh S, Chowdhury S, Das AK, Sil PC (2019) Taurine ameliorates oxidative stress induced inflammation and ER stress mediated testicular damage in STZ-induced diabetic Wistar rats. Food Chem Toxicol 124:64\u201380","journal-title":"Food Chem Toxicol"},{"key":"3470_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120525","volume":"298","author":"S Ghosh","year":"2022","unstructured":"Ghosh S, Kundu M, Dutta S, Mahalanobish S, Ghosh N, Das J, Sil PC (2022) Enhancement of anti-neoplastic effects of cuminaldehyde against breast cancer via mesoporous silica nanoparticle based targeted drug delivery system. Life Sci 298:120525","journal-title":"Life Sci"},{"key":"3470_CR17","doi-asserted-by":"publisher","unstructured":"Ghosh S, Das SK, Sinha K, Ghosh B, Sen K, Ghosh N, Sil PC (2024) The emerging role of natural products in cancer treatment. Arch Toxicol:1\u201339. https:\/\/doi.org\/10.1007\/s00204-024-03786-3","DOI":"10.1007\/s00204-024-03786-3"},{"key":"3470_CR18","doi-asserted-by":"publisher","first-page":"9352","DOI":"10.3390\/ijms24119352","volume":"24","author":"P Gonz\u00e1lez","year":"2023","unstructured":"Gonz\u00e1lez P, Lozano P, Ros G, Solano F (2023) Hyperglycemia and oxidative stress: an integral, updated and critical overview of their metabolic interconnections. Int J Mol Sci 24:9352","journal-title":"Int J Mol Sci"},{"key":"3470_CR19","first-page":"1","volume":"2023","author":"M Guo","year":"2023","unstructured":"Guo M, Chen Q, Huang Y, Wu Q, Zeng Y, Tan X, Teng F, Ma X, Pu Y, Huang W (2023) High glucose-induced kidney injury via activation of necroptosis in diabetic kidney disease. Oxid Med Cell Longev 2023:1","journal-title":"Oxid Med Cell Longev"},{"key":"3470_CR20","doi-asserted-by":"publisher","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","volume":"249","author":"WH Habig","year":"1974","unstructured":"Habig WH, Pabst MJ, Jakoby WB (1974) Glutathione S-transferases: the first enzymatic step in mercapturic acid formation. J Biol Chem 249:7130\u20137139","journal-title":"J Biol Chem"},{"key":"3470_CR21","doi-asserted-by":"publisher","first-page":"15026","DOI":"10.3390\/ijms150915026","volume":"15","author":"S Hou","year":"2014","unstructured":"Hou S, Zheng F, Li Y, Gao L, Zhang J (2014) The protective effect of glycyrrhizic acid on renal tubular epithelial cell injury induced by high glucose. Int J Mol Sci 15:15026\u201315043","journal-title":"Int J Mol Sci"},{"key":"3470_CR22","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1038\/s41419-020-03260-9","volume":"11","author":"X Huang","year":"2020","unstructured":"Huang X, Shi Y, Chen H, Le R, Gong X, Xu K, Zhu Q, Shen F, Chen Z, Gu X (2020) Isoliquiritigenin prevents hyperglycemia-induced renal injuries by inhibiting inflammation and oxidative stress via SIRT1-dependent mechanism. Cell Death Dis 11:1040","journal-title":"Cell Death Dis"},{"key":"3470_CR23","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.tcb.2011.11.002","volume":"22","author":"TR Hurd","year":"2012","unstructured":"Hurd TR, DeGennaro M, Lehmann R (2012) Redox regulation of cell migration and adhesion. Trends Cell Biol 22:107\u2013115","journal-title":"Trends Cell Biol"},{"key":"3470_CR24","doi-asserted-by":"publisher","first-page":"1185317","DOI":"10.3389\/fimmu.2023.1185317","volume":"14","author":"Q Jin","year":"2023","unstructured":"Jin Q, Liu T, Qiao Y, Liu D, Yang L, Mao H, Ma F, Wang Y, Peng L, Zhan Y (2023) Oxidative stress and inflammation in diabetic nephropathy: role of polyphenols. Front Immunol 14:1185317","journal-title":"Front Immunol"},{"key":"3470_CR25","doi-asserted-by":"publisher","first-page":"63","DOI":"10.4103\/0973-7847.79101","volume":"5","author":"R Johri","year":"2011","unstructured":"Johri R (2011) Cuminum cyminum and Carum carvi: an update. Pharmacogn Rev 5:63","journal-title":"Pharmacogn Rev"},{"key":"3470_CR26","doi-asserted-by":"crossref","unstructured":"Karmakar A, Das AK, Ghosh N, Sil PC (2022) Superoxide dismutase. Antioxidants Effects in Health. Elsevier, pp 139\u2013166","DOI":"10.1016\/B978-0-12-819096-8.00027-6"},{"key":"3470_CR27","doi-asserted-by":"publisher","first-page":"4256","DOI":"10.2174\/092986710793348581","volume":"17","author":"N Kashihara","year":"2010","unstructured":"Kashihara N, Haruna Y, Kondeti K, V, S Kanwar Y, (2010) Oxidative stress in diabetic nephropathy. Curr Med Chem 17:4256\u20134269","journal-title":"Curr Med Chem"},{"key":"3470_CR28","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s12079-021-00644-0","volume":"16","author":"MF Khan","year":"2022","unstructured":"Khan MF, Mathur A, Pandey VK, Kakkar P (2022) Naringenin alleviates hyperglycemia-induced renal toxicity by regulating activating transcription factor 4\u2013C\/EBP homologous protein mediated apoptosis. J Cell Commun Signal 16:271\u2013291","journal-title":"J Cell Commun Signal"},{"key":"3470_CR29","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/labinvest.2011.194","volume":"92","author":"SH Kim","year":"2012","unstructured":"Kim SH, Yu M-A, Ryu ES, Jang Y-H, Kang D-H (2012) Indoxyl sulfate-induced epithelial-to-mesenchymal transition and apoptosis of renal tubular cells as novel mechanisms of progression of renal disease. Lab Invest 92:488\u2013498","journal-title":"Lab Invest"},{"key":"3470_CR30","doi-asserted-by":"crossref","unstructured":"Kolatsi-Joannou M, Osborn D (2020) A technique for studying glomerular filtration integrity in the zebrafish pronephros. Diabetic Nephropathy: Methods and Protocols: 25\u201339","DOI":"10.1007\/978-1-4939-9841-8_3"},{"key":"3470_CR31","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1111\/febs.13970","volume":"284","author":"BD Larsen","year":"2017","unstructured":"Larsen BD, S\u00f8rensen CS (2017) The caspase-activated DN ase: apoptosis and beyond. FEBS J 284:1160\u20131170","journal-title":"FEBS J"},{"key":"3470_CR32","doi-asserted-by":"publisher","first-page":"2446","DOI":"10.1021\/jf048451g","volume":"53","author":"H-S Lee","year":"2005","unstructured":"Lee H-S (2005) Cuminaldehyde: aldose reductase and \u03b1-glucosidase inhibitor derived from Cuminum cyminum L. seeds. J Agric Food Chem 53:2446\u20132450","journal-title":"J Agric Food Chem"},{"key":"3470_CR33","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1007\/s00125-007-0886-7","volume":"51","author":"S Lenzen","year":"2008","unstructured":"Lenzen S (2008) The mechanisms of alloxan-and streptozotocin-induced diabetes. Diabetologia 51:216\u2013226","journal-title":"Diabetologia"},{"key":"3470_CR34","first-page":"1","volume":"24","author":"D Li","year":"2021","unstructured":"Li D, Wang L, Ou J, Wang C, Zhou J, Lu L, Wu Y, Gao J (2021) Reactive oxygen species induced by uric acid promote NRK-52E cell apoptosis through the NEK7-NLRP3 signaling pathway. Mol Med Rep 24:1\u201310","journal-title":"Mol Med Rep"},{"key":"3470_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.comptc.2023.114227","volume":"1227","author":"JC Luque-Ceballos","year":"2023","unstructured":"Luque-Ceballos JC, Rodr\u00edguez-Zamora P, L\u00f3pez-Olivos JC, Garz\u00f3n IL (2023) Revisiting the scavenging activity of glutathione: free radicals diversity and reaction mechanisms. Comput Theor Chem 1227:114227","journal-title":"Comput Theor Chem"},{"key":"3470_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2020.111588","volume":"144","author":"S Mahalanobish","year":"2020","unstructured":"Mahalanobish S, Dutta S, Saha S, Sil PC (2020) Melatonin induced suppression of ER stress and mitochondrial dysfunction inhibited NLRP3 inflammasome activation in COPD mice. Food Chem Toxicol 144:111588","journal-title":"Food Chem Toxicol"},{"key":"3470_CR37","doi-asserted-by":"publisher","first-page":"3730","DOI":"10.3390\/ijms22073730","volume":"22","author":"JL Morris","year":"2021","unstructured":"Morris JL, Gillet G, Prudent J, Popgeorgiev N (2021) Bcl-2 family of proteins in the control of mitochondrial calcium signalling: an old chap with new roles. Int J Mol Sci 22:3730","journal-title":"Int J Mol Sci"},{"key":"3470_CR38","doi-asserted-by":"publisher","first-page":"H2336","DOI":"10.1111\/1750-3841.13016","volume":"80","author":"D Morshedi","year":"2015","unstructured":"Morshedi D, Aliakbari F, Tayaranian-Marvian A, Fassihi A, Pan-Montojo F, P\u00e9rez-S\u00e1nchez H (2015) Cuminaldehyde as the major component of Cuminum cyminum, a natural aldehyde with inhibitory effect on alpha-synuclein fibrillation and cytotoxicity. J Food Sci 80:H2336\u2013H2345","journal-title":"J Food Sci"},{"key":"3470_CR39","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1017\/S0007114513000627","volume":"110","author":"SB Patil","year":"2013","unstructured":"Patil SB, Takalikar SS, Joglekar MM, Haldavnekar VS, Arvindekar AU (2013) Insulinotropic and \u03b2-cell protective action of cuminaldehyde, cuminol and an inhibitor isolated from Cuminum cyminum in streptozotocin-induced diabetic rats. Br J Nutr 110:1434\u20131443","journal-title":"Br J Nutr"},{"key":"3470_CR40","unstructured":"Rizwan S, ReddySekhar P, MalikAsrar B (2014) Reactive oxygen species in inflammation and tissue injury. Antioxidants & redox signaling"},{"key":"3470_CR41","doi-asserted-by":"crossref","unstructured":"Sagoo MK, Gnudi L (2020) Diabetic nephropathy: an overview. Diabetic nephropathy: methods and protocols: 3\u20137","DOI":"10.1007\/978-1-4939-9841-8_1"},{"key":"3470_CR42","doi-asserted-by":"crossref","unstructured":"Sellins KS, Cohen J (1987) Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes. J Immunol (Baltimore, Md: 1950) 139: 3199\u20133206","DOI":"10.4049\/jimmunol.139.10.3199"},{"key":"3470_CR43","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1007\/s00204-013-1034-4","volume":"87","author":"K Sinha","year":"2013","unstructured":"Sinha K, Das J, Pal PB, Sil PC (2013) Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis. Arch Toxicol 87:1157\u20131180","journal-title":"Arch Toxicol"},{"key":"3470_CR44","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.tiv.2013.11.011","volume":"28","author":"K Sinha","year":"2014","unstructured":"Sinha K, Pal PB, Sil PC (2014) Cadmium (Cd2+) exposure differentially elicits both cell proliferation and cell death related responses in SK-RC-45. Toxicol in Vitro 28:307\u2013318","journal-title":"Toxicol in Vitro"},{"key":"3470_CR45","doi-asserted-by":"crossref","unstructured":"Sinha K, Sadhukhan P, Saha S, Pal PB, Sil PC (2015) Morin protects gastric mucosa from nonsteroidal anti-inflammatory drug, indomethacin induced inflammatory damage and apoptosis by modulating NF-\u03baB pathway. Biochim Biophys Acta (BBA)-General Subjects 1850: 769\u2013783","DOI":"10.1016\/j.bbagen.2015.01.008"},{"key":"3470_CR46","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/0003-2697(88)90564-7","volume":"175","author":"IK Smith","year":"1988","unstructured":"Smith IK, Vierheller TL, Thorne CA (1988) Assay of glutathione reductase in crude tissue homogenates using 5, 5\u2032-dithiobis (2-nitrobenzoic acid). Anal Biochem 175:408\u2013413","journal-title":"Anal Biochem"},{"key":"3470_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10408398.2010.500223","volume":"53","author":"H Sowbhagya","year":"2013","unstructured":"Sowbhagya H (2013) Chemistry, technology, and nutraceutical functions of cumin (Cuminum cyminum L): an overview. Crit Rev Food Sci Nutr 53:1\u201310","journal-title":"Crit Rev Food Sci Nutr"},{"key":"3470_CR48","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1089\/ars.2009.2887","volume":"12","author":"YJ Suzuki","year":"2010","unstructured":"Suzuki YJ, Carini M, Butterfield DA (2010) Protein carbonylation. Antioxid Redox Signal 12:323\u2013325","journal-title":"Antioxid Redox Signal"},{"key":"3470_CR49","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.756548","volume":"12","author":"E Toren","year":"2021","unstructured":"Toren E, Burnette KS, Banerjee RR, Hunter CS, Tse HM (2021) Partners in crime: beta-cells and autoimmune responses complicit in type 1 diabetes pathogenesis. Front Immunol 12:756548","journal-title":"Front Immunol"},{"key":"3470_CR50","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23678","volume":"38","author":"A Usta","year":"2024","unstructured":"Usta A, Y\u00fcksek V, \u00c7etin S, Dede S (2024) Lycopene prevents cell death in NRK-52E cells by inhibition of high glucose-activated DNA damage and apoptotic, autophagic, and necrotic pathways. J Biochem Mol Toxicol 38:e23678","journal-title":"J Biochem Mol Toxicol"},{"key":"3470_CR51","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3389\/fmed.2018.00098","volume":"5","author":"Y Wen","year":"2018","unstructured":"Wen Y, Shah S, Campbell KN (2018) Molecular mechanisms of proteinuria in focal segmental glomerulosclerosis. Front Med 5:98","journal-title":"Front Med"},{"key":"3470_CR52","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jpha.2023.09.003","volume":"14","author":"M Yang","year":"2023","unstructured":"Yang M, Zhang C (2023) The role of innate immunity in diabetic nephropathy and their therapeutic consequences. J Pharm Anal 14:39","journal-title":"J Pharm Anal"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03470-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-024-03470-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03470-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T10:46:36Z","timestamp":1742294796000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-024-03470-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,28]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["3470"],"URL":"https:\/\/doi.org\/10.1007\/s00210-024-03470-4","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,28]]},"assertion":[{"value":"24 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}