{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T17:59:35Z","timestamp":1788803975844,"version":"build-2803163510"},"reference-count":111,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1007\/s00210-024-03507-8","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T08:01:49Z","timestamp":1728374509000},"page":"2151-2167","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Exploring chitosan nanoparticles for enhanced therapy in neurological disorders: a comprehensive review"],"prefix":"10.1007","volume":"398","author":[{"given":"Safa A","family":"Vahab","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"K I","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9333-9163","authenticated-orcid":false,"given":"Sabitha","family":"M","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9824-4788","authenticated-orcid":false,"given":"Vrinda S","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,8]]},"reference":[{"key":"3507_CR1","doi-asserted-by":"publisher","first-page":"122884","DOI":"10.1016\/j.ijpharm.2023.122884","volume":"637","author":"B Abadi","year":"2023","unstructured":"Abadi B, Khazaeli P, Forootanfar H, Ranjbar M, Ahmadi-Zeidabadi M, Nokhodchi A, Ameri A, Adeli-Sardou M, Amirinejad M (2023) Chitosan-sialic acid nanoparticles of selenium: statistical optimization of production, characterization, and assessment of cytotoxic effects against two human glioblastoma cell lines. Int J Pharm 637:122884","journal-title":"Int J Pharm"},{"key":"3507_CR2","first-page":"57","volume":"14","author":"HM Abdel-Bar","year":"2019","unstructured":"Abdel-Bar HM (2019) Optimization of chitosan nanoparticles for direct nose-to brain sumatriptan deposition IOSR. J Pharm Biol Sci 14:57\u201365","journal-title":"J Pharm Biol Sci"},{"issue":"1","key":"3507_CR3","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1186\/s11671-019-3083-y","volume":"14","author":"P Abrica-Gonz\u00e1lez","year":"2019","unstructured":"Abrica-Gonz\u00e1lez P, Zamora-Justo JA, Sotelo-L\u00f3pez A, V\u00e1zquez-Mart\u00ednez GR, Balderas-L\u00f3pez JA, Mu\u00f1oz-Diosdado A, Ib\u00e1\u00f1ez-Hern\u00e1ndez M (2019) Gold nanoparticles with chitosan, N-acylated chitosan, and chitosan oligosaccharide as DNA carriers. Nanoscale Res Lett 14(1):258","journal-title":"Nanoscale Res Lett"},{"key":"3507_CR4","first-page":"1","volume":"4","author":"S Adhikari","year":"2012","unstructured":"Adhikari S, Mandlik S, Ranpise N (2012) Formulation and in-vitro characterization of chitosan biodegradable nanoparticles of zolmitriptan for migraine treatment. Pharmacie Globale (IJCP) 4:1\u20135","journal-title":"Pharmacie Globale (IJCP)"},{"key":"3507_CR5","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.msec.2017.02.008","volume":"74","author":"P Agrawal","year":"2017","unstructured":"Agrawal P, Singh RP, Sonali, Kumari L, Sharma G, Koch B, Rajesh CV, Mehata AK, Singh S, Pandey BL, Muthu MS (2017) TPGS-chitosan cross-linked targeted nanoparticles for effective brain cancer therapy. Mater Sci Eng C Mater Biol Appl 74:167\u2013176","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"issue":"13","key":"3507_CR6","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1080\/10826076.2017.1343735","volume":"40","author":"N Ahmad","year":"2017","unstructured":"Ahmad N (2017) Rasagiline-encapsulated chitosan-coated PLGA nanoparticles targeted to the brain in the treatment of Parkinson\u2019s disease. J Liq Chromatogr Relat Technol 40(13):677\u2013690","journal-title":"J Liq Chromatogr Relat Technol"},{"key":"3507_CR7","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.ijbiomac.2022.08.210","volume":"221","author":"S Ahmad","year":"2022","unstructured":"Ahmad S, Khan I, Pandit J, Emad NA, Bano S, Dar KI, Rizvi MMA, Ansari MD, Aqil M, Sultana Y (2022) Brain targeted delivery of carmustine using chitosan coated nanoparticles via nasal route for glioblastoma treatment. Int J Biol Macromol 221:435\u2013445","journal-title":"Int J Biol Macromol"},{"issue":"6","key":"3507_CR8","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1021\/bc050217o","volume":"16","author":"Y Akta\u015f","year":"2005","unstructured":"Akta\u015f Y, Yemisci M, Andrieux K, G\u00fcrsoy RN, Alonso MJ, Fernandez-Megia E, Novoa-Carballal R, Qui\u00f1o\u00e1 E, Riguera R, Sargon MF, Celik HH, Demir AS, Hincal AA, Dalkara T, Capan Y, Couvreur P (2005) Development and brain delivery of chitosan-PEG nanoparticles functionalized with the monoclonal antibody OX26. Bioconjug Chem 16(6):1503\u20131511","journal-title":"Bioconjug Chem"},{"issue":"1","key":"3507_CR9","first-page":"2284371","volume":"2023","author":"A Alastal","year":"2023","unstructured":"Alastal A, Kwaik ADA, Malkawi AA, Baltzley S, Al-Ghananeem AM (2023) Enhancing intranasal delivery and bioavailability of dihydroergotamine utilizing chitosan nanoparticles. J Clin Pharm Ther 2023(1):2284371","journal-title":"J Clin Pharm Ther"},{"issue":"1","key":"3507_CR10","first-page":"2284371","volume":"2023","author":"A Alastal","year":"2023","unstructured":"Alastal A, Kwaik ADA, Malkawi AA, Baltzley S, Al-Ghananeem AM, Jiao P (2023) Enhancing intranasal delivery and bioavailability of dihydroergotamine utilizing chitosan nanoparticles. J Clin Pharm Ther 2023(1):2284371","journal-title":"J Clin Pharm Ther"},{"issue":"12","key":"3507_CR11","doi-asserted-by":"publisher","first-page":"2742","DOI":"10.3390\/pharmaceutics14122742","volume":"14","author":"M Alberto","year":"2022","unstructured":"Alberto M, Paiva-Santos AC, Veiga F, Pires PC (2022) Lipid and polymeric nanoparticles: successful strategies for nose-to-brain drug delivery in the treatment of depression and anxiety disorders. Pharmaceutics 14(12):2742","journal-title":"Pharmaceutics"},{"issue":"3","key":"3507_CR12","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1002\/jbm.a.36827","volume":"108","author":"M Alipour","year":"2020","unstructured":"Alipour M, Reza Bigdeli M, Aligholi H, Rasoulian B, Khaksarian M (2020) Sustained release of silibinin-loaded chitosan nanoparticle induced apoptosis in glioma cells. J Biomed Mater Res Part A 108(3):458\u2013469","journal-title":"J Biomed Mater Res Part A"},{"issue":"1","key":"3507_CR13","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.vaccine.2006.06.086","volume":"25","author":"M Amidi","year":"2007","unstructured":"Amidi M, Romeijn SG, Verhoef JC, Junginger HE, Bungener L, Huckriede A, Crommelin DJ, Jiskoot W (2007) N-Trimethyl chitosan (TMC) nanoparticles loaded with influenza subunit antigen for intranasal vaccination: biological properties and immunogenicity in a mouse model. Vaccine 25(1):144\u2013153","journal-title":"Vaccine"},{"issue":"19","key":"3507_CR14","doi-asserted-by":"publisher","first-page":"3256","DOI":"10.3390\/polym13193256","volume":"13","author":"I Aranaz","year":"2021","unstructured":"Aranaz I, Alc\u00e1ntara AR, Civera MC, Arias C, Elorza B, Heras Caballero A, Acosta N (2021) Chitosan: an overview of its properties and applications. Polymers 13(19):3256","journal-title":"Polymers"},{"issue":"104388","key":"3507_CR15","doi-asserted-by":"publisher","first-page":"104388","DOI":"10.1016\/j.jddst.2023.104388","volume":"83","author":"BH Asghar","year":"2023","unstructured":"Asghar BH, Hassan RKA, Barakat LAA, Alharbi A, El Behery M, Elshaarawy RFM, Hassan YA (2023) Cross-linked quaternized chitosan nanoparticles for effective delivery and controllable release of O. europaea phenolic extract targeting cancer therapy. J Drug Deliv Sci Technol 83(104388):104388","journal-title":"J Drug Deliv Sci Technol"},{"issue":"1","key":"3507_CR16","first-page":"90","volume":"13","author":"S Assadpour","year":"2022","unstructured":"Assadpour S, Akhtari J, Shiran MR (2022) Pharmacokinetics study of chitosan-coated liposomes containing sumatriptan in the treatment of migraine. Caspian J Intern Med 13(1):90\u201399","journal-title":"Caspian J Intern Med"},{"key":"3507_CR17","doi-asserted-by":"publisher","first-page":"8553","DOI":"10.2147\/IJN.S274352","volume":"15","author":"RH Awadeen","year":"2020","unstructured":"Awadeen RH, Boughdady MF, Meshali MM (2020) Quality by design approach for preparation of zolmitriptan\/chitosan nanostructured lipid carrier particles - formulation and pharmacodynamic assessment. Int J Nanomed 15:8553\u20138568","journal-title":"Int J Nanomed"},{"issue":"11","key":"3507_CR18","doi-asserted-by":"publisher","first-page":"3044","DOI":"10.1039\/D3NA00253E","volume":"5","author":"T Baati","year":"2023","unstructured":"Baati T, Chaabani I, Salek A, Njim L, Selmi M, Al-Kattan A, Hosni K (2023) Chitosan-coated ultrapure silicon nanoparticles produced by laser ablation: biomedical potential in nano-oncology as a tumour-targeting nanosystem. Nanoscale Adv 5(11):3044\u20133052","journal-title":"Nanoscale Adv"},{"issue":"6","key":"3507_CR19","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1208\/s12249-014-0189-5","volume":"15","author":"S Baltzley","year":"2014","unstructured":"Baltzley S, Mohammad A, Malkawi AH, Al-Ghananeem AM (2014) Intranasal drug delivery of olanzapine-loaded chitosan nanoparticles. AAPS PharmSciTech 15(6):1598\u20131602","journal-title":"AAPS PharmSciTech"},{"key":"3507_CR20","doi-asserted-by":"publisher","first-page":"119674","DOI":"10.1016\/j.ijpharm.2020.119674","volume":"587","author":"A Bazzazzadeh","year":"2020","unstructured":"Bazzazzadeh A, Dizaji BF, Kianinejad N, Nouri A, Irani M (2020) Fabrication of poly(acrylic acid) grafted-chitosan\/polyurethane\/magnetic MIL-53 metal organic framework composite core-shell nanofibers for co-delivery of temozolomide and paclitaxel against glioblastoma cancer cells. Int J Pharm 587:119674","journal-title":"Int J Pharm"},{"issue":"119148","key":"3507_CR21","doi-asserted-by":"publisher","first-page":"119148","DOI":"10.1016\/j.ijpharm.2020.119148","volume":"579","author":"SK Bhattamisra","year":"2020","unstructured":"Bhattamisra SK, Shak AT, Xi LW, Safian NH, Choudhury H, Lim WM, Shahzad N, Alhakamy NA, Anwer MK, Radhakrishnan AK, Md S (2020) Nose to brain delivery of rotigotine loaded chitosan nanoparticles in human SH-SY5Y neuroblastoma cells and animal model of Parkinson\u2019s disease. Int J Pharm 579(119148):119148","journal-title":"Int J Pharm"},{"issue":"5","key":"3507_CR22","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1021\/bm0502258","volume":"6","author":"M Bodnar","year":"2005","unstructured":"Bodnar M, Hartmann JF, Borbely J (2005) Preparation and characterization of chitosan-based nanoparticles. Biomacromol 6(5):2521\u20132527","journal-title":"Biomacromol"},{"key":"3507_CR23","doi-asserted-by":"publisher","first-page":"121563","DOI":"10.1016\/j.ijpharm.2022.121563","volume":"616","author":"FA Bruinsmann","year":"2022","unstructured":"Bruinsmann FA, de Cristo Soares Alves A, de Fraga Dias A, Lopes Silva LF, Visioli F, Raffin Pohlmann A, Figueir\u00f3 F, Sonvico F, Stanis\u00e7uaski Guterres S (2022) Nose-to-brain delivery of simvastatin mediated by chitosan-coated lipid-core nanocapsules allows for the treatment of glioblastoma in vivo. Int J Pharm 616:121563","journal-title":"Int J Pharm"},{"issue":"2","key":"3507_CR24","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3390\/biomedicines12020287","volume":"12","author":"F Canbolat","year":"2024","unstructured":"Canbolat F, Demir N, Yay\u0131ntas OT, Pehlivan M, Eldem A, Ayna TK, Senel M (2024) Chitosan nanoparticles loaded with quercetin and valproic acid: a novel approach for enhancing antioxidant activity against oxidative stress in the SH-SY5Y human neuroblastoma cell line. Biomedicines 12(2):287","journal-title":"Biomedicines"},{"issue":"119776","key":"3507_CR25","doi-asserted-by":"publisher","first-page":"119776","DOI":"10.1016\/j.ijpharm.2020.119776","volume":"589","author":"A-T Chatzitaki","year":"2020","unstructured":"Chatzitaki A-T, Jesus S, Karavasili C, Andreadis D, Fatouros DG, Borges O (2020) Chitosan-coated PLGA nanoparticles for the nasal delivery of ropinirole hydrochloride: in vitro and ex vivo evaluation of efficacy and safety. Int J Pharm 589(119776):119776","journal-title":"Int J Pharm"},{"key":"3507_CR26","doi-asserted-by":"publisher","first-page":"1190920","DOI":"10.3389\/fphar.2023.1190920","volume":"14","author":"Y Chen","year":"2023","unstructured":"Chen Y, Cheng Q, Zeng S, Lv S (2023) Potential analgesic effect of Foshousan oil-loaded chitosan-alginate nanoparticles on the treatment of migraine. Front Pharmacol 14:1190920. https:\/\/doi.org\/10.3389\/fphar.2023.1190920","journal-title":"Front Pharmacol"},{"issue":"9","key":"3507_CR27","doi-asserted-by":"publisher","first-page":"212","DOI":"10.3390\/membranes10090212","volume":"10","author":"H Cort\u00e9s","year":"2020","unstructured":"Cort\u00e9s H, Alcal\u00e1-Alcal\u00e1 S, Caballero-Flor\u00e1n IH, Bernal-Ch\u00e1vez SA, \u00c1valos-Fuentes A, Gonz\u00e1lez-Torres M, Gonz\u00e1lez-Del Carmen M, Figueroa-Gonz\u00e1lez G, Reyes-Hern\u00e1ndez OD, Floran B, Del Prado-Audelo ML, Leyva-G\u00f3mez G (2020) A reevaluation of chitosan-decorated nanoparticles to cross the blood-brain barrier. Membranes 10(9):212","journal-title":"Membranes"},{"issue":"20","key":"3507_CR28","doi-asserted-by":"publisher","first-page":"2886","DOI":"10.1016\/j.vaccine.2018.02.072","volume":"36","author":"M Dabaghian","year":"2018","unstructured":"Dabaghian M, Latifi AM, Tebianian M, NajmiNejad H, Ebrahimi SM (2018) Nasal vaccination with r4M2e.HSP70c antigen encapsulated into N-trimethyl chitosan (TMC) nanoparticulate systems: preparation and immunogenicity in a mouse model. Vaccine 36(20):2886\u20132895. https:\/\/doi.org\/10.1016\/j.vaccine.2018.02.072","journal-title":"Vaccine"},{"key":"3507_CR29","doi-asserted-by":"publisher","first-page":"691936","DOI":"10.3389\/fphar.2021.691936","volume":"12","author":"A Dalvi","year":"2021","unstructured":"Dalvi A, Ravi PR, Uppuluri CT (2021) Rufinamide-loaded chitosan nanoparticles in xyloglucan-based thermoresponsive in situ gel for direct nose to brain delivery. Front Pharmacol 12:691936","journal-title":"Front Pharmacol"},{"issue":"1","key":"3507_CR30","doi-asserted-by":"publisher","first-page":"8247","DOI":"10.1038\/s41598-024-58601-x","volume":"14","author":"AB Darwish","year":"2024","unstructured":"Darwish AB, Mohsen AM, ElShebiney S, Elgohary R, Younis MM (2024) Development of chitosan lipid nanoparticles to alleviate the pharmacological activity of piperine in the management of cognitive deficit in diabetic rats. Sci Rep 14(1):8247","journal-title":"Sci Rep"},{"issue":"Pt 1","key":"3507_CR31","doi-asserted-by":"publisher","first-page":"129401","DOI":"10.1016\/j.ijbiomac.2024.129401","volume":"260","author":"BS Dash","year":"2024","unstructured":"Dash BS, Lu YJ, Huang YS, Chen JP (2024) Chitosan-coated magnetic graphene oxide for targeted delivery of doxorubicin as a nanomedicine approach to treat glioblastoma. Int J Biol Macromol 260(Pt 1):129401","journal-title":"Int J Biol Macromol"},{"issue":"4","key":"3507_CR32","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.3390\/pharmaceutics15041313","volume":"15","author":"N Desai","year":"2023","unstructured":"Desai N, Rana D, Salave S, Gupta R, Patel P, Karunakaran B, Sharma A, Giri J, Benival D, Kommineni N (2023) Chitosan: a potential biopolymer in drug delivery and biomedical applications. Pharmaceutics 15(4):1313","journal-title":"Pharmaceutics"},{"issue":"1","key":"3507_CR33","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3390\/pharmaceutics16010058","volume":"16","author":"S Dighe","year":"2023","unstructured":"Dighe S, Jog S, Momin M, Sawarkar S, Omri A (2023) Intranasal drug delivery by nanotechnology: advances in and challenges for Alzheimer\u2019s disease management. Pharmaceutics 16(1):58","journal-title":"Pharmaceutics"},{"issue":"2","key":"3507_CR34","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1007\/s00289-023-04755-z","volume":"81","author":"F Dilnawaz","year":"2023","unstructured":"Dilnawaz F, Acharya S, Kanungo A (2023) A clinical perspective of chitosan nanoparticles for infectious disease management. Polym Bull (Berlin Germany) 81(2):1071\u20131095","journal-title":"Polym Bull (Berlin Germany)"},{"issue":"3","key":"3507_CR35","first-page":"411","volume":"4","author":"D Elieh-Ali-Komi","year":"2016","unstructured":"Elieh-Ali-Komi D, Hamblin MR (2016) Chitin and chitosan: production and application of versatile biomedical nanomaterials. Int J Adv Res 4(3):411\u2013427","journal-title":"Int J Adv Res"},{"issue":"2","key":"3507_CR36","doi-asserted-by":"publisher","first-page":"160","DOI":"10.3390\/pharmaceutics12020160","volume":"12","author":"M Elmowafy","year":"2020","unstructured":"Elmowafy M, Alruwaili NK, Shalaby K, Alharbi KS, Altowayan WM, Ahmad N, Zafar A, Elkomy M (2020) Long-acting paliperidone parenteral formulations based on polycaprolactone nanoparticles; the influence of stabilizer and chitosan on in vitro release, protein adsorption, and cytotoxicity. Pharmaceutics 12(2):160","journal-title":"Pharmaceutics"},{"issue":"1","key":"3507_CR37","doi-asserted-by":"publisher","first-page":"19869","DOI":"10.1038\/s41598-022-24303-5","volume":"12","author":"NE-A El-Naggar","year":"2022","unstructured":"El-Naggar NE-A, Shiha AM, Mahrous H, Mohammed ABA (2022) Green synthesis of chitosan nanoparticles, optimization, characterization and antibacterial efficacy against multi drug resistant biofilm-forming Acinetobacter baumannii. Sci Rep 12(1):19869","journal-title":"Sci Rep"},{"key":"3507_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/502058","volume":"2015","author":"R Esquivel","year":"2015","unstructured":"Esquivel R, Ju\u00e1rez J, Almada M, Ibarra J, Valdez MA (2015) Synthesis and characterization of new thiolated chitosan nanoparticles obtained by ionic gelation method. Int J Polym Sci 2015:1\u201318","journal-title":"Int J Polym Sci"},{"issue":"1\u20132","key":"3507_CR39","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.ijpharm.2018.06.031","volume":"547","author":"J Fernandes","year":"2018","unstructured":"Fernandes J, Ghate MV, Basu Mallik S, Lewis SA (2018) Amino acid conjugated chitosan nanoparticles for the brain targeting of a model dipeptidyl peptidase-4 inhibitor. Int J Pharm 547(1\u20132):563\u2013571","journal-title":"Int J Pharm"},{"issue":"3","key":"3507_CR40","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1007\/s13346-022-01245-z","volume":"13","author":"B Gabold","year":"2023","unstructured":"Gabold B, Adams F, Brameyer S, Jung K, Ried CL, Merdan T, Merkel OM (2023) Transferrin-modified chitosan nanoparticles for targeted nose-to-brain delivery of proteins. Drug Deliv Transl Res 13(3):822\u2013838","journal-title":"Drug Deliv Transl Res"},{"issue":"1","key":"3507_CR41","doi-asserted-by":"publisher","first-page":"204","DOI":"10.3390\/molecules27010204","volume":"27","author":"X Gao","year":"2021","unstructured":"Gao X, Liu N, Wang Z, Gao J, Zhang H, Li M, Du Y, Gao X, Zheng A (2021) Development and optimization of chitosan nanoparticle-based intranasal vaccine carrier. Molecules (Basel Switzerland) 27(1):204","journal-title":"Molecules (Basel Switzerland)"},{"issue":"2","key":"3507_CR42","doi-asserted-by":"publisher","first-page":"195","DOI":"10.15171\/apb.2019.023","volume":"9","author":"U Garg","year":"2019","unstructured":"Garg U, Chauhan S, Nagaich U, Jain N (2019) Current advances in chitosan nanoparticles based drug delivery and targeting. Adv Pharm Bull 9(2):195\u2013204","journal-title":"Adv Pharm Bull"},{"issue":"3","key":"3507_CR43","doi-asserted-by":"publisher","first-page":"829","DOI":"10.3390\/pharmaceutics15030829","volume":"15","author":"D Georgieva","year":"2023","unstructured":"Georgieva D, Nikolova D, Vassileva E, Kostova B (2023) Chitosan-based nanoparticles for targeted nasal galantamine delivery as a promising tool in Alzheimer\u2019s disease therapy. Pharmaceutics 15(3):829","journal-title":"Pharmaceutics"},{"issue":"3","key":"3507_CR44","first-page":"156","volume":"5","author":"A Ghadi","year":"2014","unstructured":"Ghadi A, Mahjoub S, Tabandeh F, Talebnia F (2014) Synthesis and optimization of chitosan nanoparticles: potential applications in nanomedicine and biomedical engineering. Caspian J Intern Med 5(3):156\u2013161","journal-title":"Caspian J Intern Med"},{"issue":"3","key":"3507_CR45","doi-asserted-by":"publisher","first-page":"843","DOI":"10.3797\/scipharm.1208-18","volume":"81","author":"N Gulati","year":"2013","unstructured":"Gulati N, Nagaich U, Saraf SA (2013) Intranasal delivery of chitosan nanoparticles for migraine therapy. Sci Pharm 81(3):843\u2013854","journal-title":"Sci Pharm"},{"key":"3507_CR46","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.ijbiomac.2015.08.035","volume":"81","author":"GP Hansraj","year":"2015","unstructured":"Hansraj GP, Singh SK, Kumar P (2015) Sumatriptan succinate loaded chitosan solid lipid nanoparticles for enhanced anti-migraine potential. Int J Biol Macromol 81:467\u2013476","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"3507_CR47","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.carbpol.2012.02.051","volume":"89","author":"S Haque","year":"2012","unstructured":"Haque S, Md S, Fazil M, Kumar M, Sahni JK, Ali J, Baboota S (2012) Venlafaxine loaded chitosan NPs for brain targeting: pharmacokinetic and pharmacodynamic evaluation. Carbohyd Polym 89(1):72\u201379","journal-title":"Carbohyd Polym"},{"key":"3507_CR48","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.brainresbull.2020.03.018","volume":"160","author":"S Harilal","year":"2020","unstructured":"Harilal S, Jose J, Parambi DGT, Kumar R, Unnikrishnan MK, Uddin MS, Mathew GE, Pratap R, Marathakam A, Mathew B (2020) Revisiting the blood-brain barrier: a hard nut to crack in the transportation of drug molecules. Brain Res Bull 160:121\u2013140","journal-title":"Brain Res Bull"},{"issue":"2","key":"3507_CR49","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1007\/s13346-023-01407-7","volume":"14","author":"DM Hassan","year":"2024","unstructured":"Hassan DM, El-Kamel AH, Allam EA, Bakr BA, Ashour AA (2024) Chitosan-coated nanostructured lipid carriers for effective brain delivery of Tanshinone IIA in Parkinson\u2019s disease: interplay between nuclear factor-kappa \u03b2 and cathepsin B. Drug Deliv Transl Res 14(2):400\u2013417","journal-title":"Drug Deliv Transl Res"},{"issue":"1","key":"3507_CR50","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3390\/molecules29010031","volume":"29","author":"H Imran","year":"2023","unstructured":"Imran H, Tang Y, Wang S, Yan X, Liu C, Guo L, Wang E, Xu C (2023) Optimized DOX drug deliveries via chitosan-mediated nanoparticles and stimuli responses in cancer chemotherapy: a review. Molecules (Basel Switzerland) 29(1):31","journal-title":"Molecules (Basel Switzerland)"},{"issue":"4","key":"3507_CR51","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.3390\/molecules28041963","volume":"28","author":"K Jafernik","year":"2023","unstructured":"Jafernik K, \u0141adniak A, Blicharska E, Czarnek K, Ekiert H, Wi\u0105cek AE, Szopa A (2023) Chitosan-based nanoparticles as effective drug delivery systems-a review. Molecules (Basel, Switzerland) 28(4):1963","journal-title":"Molecules (Basel, Switzerland)"},{"issue":"2","key":"3507_CR52","doi-asserted-by":"publisher","first-page":"272","DOI":"10.3390\/molecules26020272","volume":"26","author":"J Jhaveri","year":"2021","unstructured":"Jhaveri J, Raichura Z, Khan T, Momin M, Omri A (2021) Chitosan nanoparticles-insight into properties, functionalization and applications in drug delivery and theranostics. Molecules (Basel Switzerland) 26(2):272","journal-title":"Molecules (Basel Switzerland)"},{"issue":"17","key":"3507_CR53","doi-asserted-by":"publisher","first-page":"3981","DOI":"10.3390\/molecules25173981","volume":"25","author":"CP Jim\u00e9nez-G\u00f3mez","year":"2020","unstructured":"Jim\u00e9nez-G\u00f3mez CP, Cecilia JA (2020) Chitosan: a natural biopolymer with a wide and varied range of applications. Molecules (Basel Switzerland) 25(17):3981","journal-title":"Molecules (Basel Switzerland)"},{"issue":"100316","key":"3507_CR54","first-page":"100316","volume":"5","author":"G Kaur","year":"2023","unstructured":"Kaur G, Goyal J, Behera PK, Devi S, Singh SK, Garg V, Mittal N (2023) Unraveling the role of chitosan for nasal drug delivery systems: a review. Carbohydr Polym Technol Appl 5(100316):100316","journal-title":"Carbohydr Polym Technol Appl"},{"key":"3507_CR55","doi-asserted-by":"publisher","first-page":"108368","DOI":"10.1016\/j.carres.2021.108368","volume":"506","author":"A Khan","year":"2021","unstructured":"Khan A, Alamry KA (2021) Recent advances of emerging green chitosan-based biomaterials with potential biomedical applications: a review. Carbohyd Res 506:108368","journal-title":"Carbohyd Res"},{"issue":"2","key":"3507_CR56","doi-asserted-by":"publisher","first-page":"169","DOI":"10.3390\/ph17020169","volume":"17","author":"IN Khan","year":"2024","unstructured":"Khan IN, Navaid S, Waqar W, Hussein D, Ullah N, Khan MUA, Hussain Z, Javed A (2024) Chitosan-based polymeric nanoparticles as an efficient gene delivery system to cross blood brain barrier: in vitro and in vivo evaluations. Pharmaceuticals (Basel Switzerland) 17(2):169","journal-title":"Pharmaceuticals (Basel Switzerland)"},{"key":"3507_CR57","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.ijbiomac.2019.08.236","volume":"142","author":"FANZ Khezri","year":"2020","unstructured":"Khezri FANZ, Lakshmi CSR, Bukka R, Nidhi M, Nargund SL (2020) Pharmacokinetic study and brain tissue analysis of Zolmitriptan loaded chitosan nanoparticles in rats by LC-MS method. Int J Biol Macromol 142:52\u201362","journal-title":"Int J Biol Macromol"},{"issue":"7","key":"3507_CR58","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.3390\/md8071988","volume":"8","author":"F Khoushab","year":"2010","unstructured":"Khoushab F, Yamabhai M (2010) Chitin research revisited. Mar Drugs 8(7):1988\u20132012","journal-title":"Mar Drugs"},{"issue":"7","key":"3507_CR59","doi-asserted-by":"publisher","first-page":"700","DOI":"10.3109\/02652048.2014.913727","volume":"31","author":"C Kutlu","year":"2014","unstructured":"Kutlu C, \u00c7akmak AS, G\u00fcm\u00fc\u015fderelio\u011flu M (2014) Double-effective chitosan scaffold-PLGA nanoparticle system for brain tumour therapy: in vitro study. J Microencapsul 31(7):700\u2013707","journal-title":"J Microencapsul"},{"key":"3507_CR60","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.colsurfb.2018.09.047","volume":"173","author":"S Lakkadwala","year":"2019","unstructured":"Lakkadwala S, Singh J (2019) Co-delivery of doxorubicin and erlotinib through liposomal nanoparticles for glioblastoma tumour regression using an in vitro brain tumour model. Colloids Surf B Biointerfaces 173:27\u201335","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"2","key":"3507_CR61","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1021\/acs.molpharmaceut.5b00707","volume":"13","author":"F Lebre","year":"2016","unstructured":"Lebre F, Borchard G, Faneca H, Pedroso de Lima MC, Borges O (2016) Intranasal administration of novel chitosan nanoparticle\/DNA complexes induces antibody response to hepatitis B surface antigen in mice. Mol Pharm 13(2):472\u2013482","journal-title":"Mol Pharm"},{"issue":"1","key":"3507_CR62","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1007\/s11095-014-1441-0","volume":"32","author":"Q Liu","year":"2015","unstructured":"Liu Q, Zheng X, Zhang C, Shao X, Zhang X, Zhang Q, Jiang X (2015) Antigen-conjugated N-trimethylaminoethylmethacrylate chitosan nanoparticles induce strong immune responses after nasal administration. Pharm Res 32(1):22\u201336. https:\/\/doi.org\/10.1007\/s11095-014-1441-0","journal-title":"Pharm Res"},{"issue":"1","key":"3507_CR63","first-page":"72","volume":"13","author":"S Liu","year":"2018","unstructured":"Liu S, Yang S, Ho PC (2018) Intranasal administration of carbamazepine-loaded carboxymethyl chitosan nanoparticles for drug delivery to the brain. Asian J Pharm Sci 13(1):72\u201381","journal-title":"Asian J Pharm Sci"},{"issue":"6","key":"3507_CR64","doi-asserted-by":"publisher","first-page":"297","DOI":"10.21037\/atm-22-288","volume":"10","author":"C Liu","year":"2022","unstructured":"Liu C, Gao Y, Zhao L, Wang R, Xie F, Zhai G, Liu A (2022) The development of a redox-sensitive curcumin conjugated chitosan oligosaccharide nanocarrier for the efficient delivery of docetaxel to glioma cells. Ann Transl Med 10(6):297","journal-title":"Ann Transl Med"},{"issue":"64","key":"3507_CR65","doi-asserted-by":"publisher","first-page":"59250","DOI":"10.1039\/C6RA06563E","volume":"6","author":"AG Luque-Alcaraz","year":"2016","unstructured":"Luque-Alcaraz AG, Lizardi-Mendoza J, Goycoolea FM, Higuera-Ciapara I, Arg\u00fcelles-Monal W (2016) Preparation of chitosan nanoparticles by nanoprecipitation and their ability as a drug nanocarrier. RSC Adv 6(64):59250\u201359256","journal-title":"RSC Adv"},{"key":"3507_CR66","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/978-1-4939-0363-4_15","volume":"1141","author":"M Malhotra","year":"2014","unstructured":"Malhotra M, Tomaro-Duchesneau C, Saha S, Prakash S (2014) Intranasal delivery of chitosan-siRNA nanoparticle formulation to the brain. Methods Mol Biol (Clifton NJ) 1141:233\u2013247","journal-title":"Methods Mol Biol (Clifton NJ)"},{"issue":"3","key":"3507_CR67","first-page":"393","volume":"48","author":"S Md","year":"2013","unstructured":"Md S, Khan RA, Mustafa G, Chuttani K, Baboota S, Sahni JK, Ali J (2013) Bromocriptine loaded chitosan nanoparticles intended for direct nose to brain delivery: Pharmacodynamic, Pharmacokinetic and Scintigraphy study in mice model. Eur J Pharm Sci Off J Eur Fed Pharm Sci 48(3):393\u2013405","journal-title":"Eur J Pharm Sci Off J Eur Fed Pharm Sci"},{"issue":"10","key":"3507_CR68","doi-asserted-by":"publisher","first-page":"275","DOI":"10.3390\/brainsci9100275","volume":"9","author":"S Md","year":"2019","unstructured":"Md S, Alhakamy NA, Aldawsari HM, Asfour HZ (2019) Neuroprotective and antioxidant effect of naringenin-loaded nanoparticles for nose-to-brain delivery. Brain Sci 9(10):275","journal-title":"Brain Sci"},{"issue":"2","key":"3507_CR69","first-page":"1","volume":"7","author":"DN Mishra","year":"2016","unstructured":"Mishra DN, Singh SK (2016) Development and characterisation of zolmitriptan thiolated chitosan nanoparticles. Int J Pharma Prof Res (IJPPR) 7(2):1\u20135","journal-title":"Int J Pharma Prof Res (IJPPR)"},{"issue":"9","key":"3507_CR70","first-page":"1373","volume":"6","author":"AS Moghaddam","year":"2020","unstructured":"Moghaddam AS, Khonakdar HA, Sarikhani E, Jafari SH, Javadi A, Shamsi M, Amirkhani MA, Ahadian S (2020) Fabrication of carboxymethyl chitosan nanoparticles to deliver paclitaxel for melanoma treatment. ChemNanoMat Chem Nanomater Energy Biol More 6(9):1373\u20131385","journal-title":"ChemNanoMat Chem Nanomater Energy Biol More"},{"issue":"4","key":"3507_CR71","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3390\/pharmaceutics9040053","volume":"9","author":"MA Mohammed","year":"2017","unstructured":"Mohammed MA, Syeda JTM, Wasan KM, Wasan EK (2017) An overview of chitosan nanoparticles and its application in non-parenteral drug delivery. Pharmaceutics 9(4):53","journal-title":"Pharmaceutics"},{"issue":"11","key":"3507_CR72","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.2217\/nnm.15.29","volume":"10","author":"Y Monsalve","year":"2015","unstructured":"Monsalve Y, Tosi G, Ruozi B, Belletti D, Vilella A, Zoli M, Vandelli MA, Forni F, L\u00f3pez BL, Sierra L (2015) PEG-g-chitosan nanoparticles functionalized with the monoclonal antibody OX26 for brain drug targeting. Nanomedicine (Lond) 10(11):1735\u20131750","journal-title":"Nanomedicine (Lond)"},{"key":"3507_CR73","doi-asserted-by":"publisher","first-page":"389","DOI":"10.3389\/fbioe.2020.00389","volume":"8","author":"DD Ojeda-Hern\u00e1ndez","year":"2020","unstructured":"Ojeda-Hern\u00e1ndez DD, Canales-Aguirre AA, Matias-Guiu J, Gomez-Pinedo U, Mateos-D\u00edaz JC (2020) Potential of chitosan and its derivatives for biomedical applications in the central nervous system. Front Bioeng Biotechnol 8:389","journal-title":"Front Bioeng Biotechnol"},{"key":"3507_CR74","doi-asserted-by":"publisher","first-page":"389","DOI":"10.3389\/fbioe.2020.00389","volume":"8","author":"DD Ojeda-Hern\u00e1ndez","year":"2020","unstructured":"Ojeda-Hern\u00e1ndez DD, Canales-Aguirre AA, Matias-Guiu J, Gomez-Pinedo U, Mateos-D\u00edaz JC (2020) Potential of chitosan and its derivatives for biomedical applications in the central nervous system. Front Bioeng Biotechnol 8:389","journal-title":"Front Bioeng Biotechnol"},{"issue":"Pt 4","key":"3507_CR75","doi-asserted-by":"publisher","first-page":"127091","DOI":"10.1016\/j.ijbiomac.2023.127091","volume":"253","author":"S Ostovar","year":"2023","unstructured":"Ostovar S, Pourmadadi M, Zaker MA (2023) Co-biopolymer of chitosan\/carboxymethyl cellulose hydrogel improved by zinc oxide and graphene quantum dots nanoparticles as pH-sensitive nanocomposite for quercetin delivery to brain cancer treatment. Int J Biol Macromol 253(Pt 4):127091","journal-title":"Int J Biol Macromol"},{"issue":"13","key":"3507_CR76","doi-asserted-by":"publisher","first-page":"4950","DOI":"10.3390\/molecules28134950","volume":"28","author":"M Owczarek","year":"2023","unstructured":"Owczarek M, Herczy\u0144ska L, Sitarek P, Kowalczyk T, Synowiec E, \u015aliwi\u0144ski T, Kruci\u0144ska I (2023) Chitosan nanoparticles-preparation, characterization and their combination with Ginkgo biloba extract in preliminary in vitro studies. Molecules (Basel Switzerland) 28(13):4950","journal-title":"Molecules (Basel Switzerland)"},{"issue":"2","key":"3507_CR77","doi-asserted-by":"publisher","first-page":"120","DOI":"10.2174\/2210303113666230120124831","volume":"13","author":"T Pandya","year":"2023","unstructured":"Pandya T, Dharamsi A (2023) Intranasal delivery of leuprolide acetate chitosan nanoparticles for treatment of Alzheimer\u2019s disease. Drug Deliv Lett 13(2):120\u2013132","journal-title":"Drug Deliv Lett"},{"issue":"1","key":"3507_CR78","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s12951-018-0392-8","volume":"16","author":"JK Patra","year":"2018","unstructured":"Patra JK, Das G, Fraceto LF, Campos EVR, Rodriguez-Torres MDP, Acosta-Torres LS, Diaz-Torres LA, Grillo R, Swamy MK, Sharma S, Habtemariam S, Shin H-S (2018) Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnol 16(1):71","journal-title":"J Nanobiotechnol"},{"issue":"1","key":"3507_CR79","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3109\/10717544.2014.908427","volume":"23","author":"D Pawar","year":"2016","unstructured":"Pawar D, Jaganathan KS (2016) Mucoadhesive glycol chitosan nanoparticles for intranasal delivery of hepatitis B vaccine: enhancement of mucosal and systemic immune response. Drug Deliv 23(1):185\u2013194. https:\/\/doi.org\/10.3109\/10717544.2014.908427","journal-title":"Drug Deliv"},{"issue":"18","key":"3507_CR80","doi-asserted-by":"publisher","first-page":"14044","DOI":"10.3390\/ijms241814044","volume":"24","author":"N Puranik","year":"2023","unstructured":"Puranik N, Yadav D, Song M (2023) Advancements in the application of nanomedicine in Alzheimer\u2019s disease: a therapeutic perspective. Int J Mol Sci 24(18):14044","journal-title":"Int J Mol Sci"},{"issue":"8","key":"3507_CR81","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1177\/0885328219890071","volume":"34","author":"RR Radwan","year":"2020","unstructured":"Radwan RR, Abdel Ghaffar AM, Ali HE (2020) Gamma radiation preparation of chitosan nanoparticles for controlled delivery of memantine. J Biomater Appl 34(8):1150\u20131162","journal-title":"J Biomater Appl"},{"key":"3507_CR82","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.ijbiomac.2017.12.056","volume":"109","author":"R Raj","year":"2018","unstructured":"Raj R, Wairkar S, Sridhar V, Gaud R (2018) Pramipexole dihydrochloride loaded chitosan nanoparticles for nose to brain delivery: development, characterization and in vivo anti-Parkinson activity. Int J Biol Macromol 109:27\u201335","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"3507_CR83","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s13233-023-00114-z","volume":"31","author":"G Rajamanickam","year":"2023","unstructured":"Rajamanickam G, Manju SL (2023) Formulation and characterization of chitosan nanoparticles loaded with neuroprotective flavonoid from Phyllanthus niruri Linn. Macromol Res 31(1):13\u201324","journal-title":"Macromol Res"},{"key":"3507_CR84","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jddst.2018.08.016","volume":"48","author":"S Ray","year":"2018","unstructured":"Ray S, Sinha P, Laha B, Maiti S, Bhattacharyya UK, Nayak AK (2018) Polysorbate 80 coated crosslinked chitosan nanoparticles of ropinirole hydrochloride for brain targeting. J Drug Deliv Sci Technol 48:21\u201329","journal-title":"J Drug Deliv Sci Technol"},{"issue":"8","key":"3507_CR85","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1080\/03639045.2019.1619759","volume":"45","author":"R Rukmangathen","year":"2019","unstructured":"Rukmangathen R, Yallamalli IM, Yalavarthi PR (2019) Formulation and biopharmaceutical evaluation of risperidone-loaded chitosan nanoparticles for intranasal delivery. Drug Dev Ind Pharm 45(8):1342\u20131350","journal-title":"Drug Dev Ind Pharm"},{"issue":"3","key":"3507_CR86","doi-asserted-by":"publisher","first-page":"660","DOI":"10.3390\/molecules26030660","volume":"26","author":"P Sacco","year":"2021","unstructured":"Sacco P, Pedroso-Santana S, Kumar Y, Joly N, Martin P, Bocchetta P (2021) Ionotropic gelation of chitosan flat structures and potential applications. Molecules (Basel Switzerland) 26(3):660","journal-title":"Molecules (Basel Switzerland)"},{"key":"3507_CR87","doi-asserted-by":"publisher","first-page":"111838","DOI":"10.1016\/j.colsurfb.2021.111838","volume":"205","author":"S Saini","year":"2021","unstructured":"Saini S, Sharma T, Jain A, Kaur H, Katare OP, Singh B (2021) Systematically designed chitosan-coated solid lipid nanoparticles of ferulic acid for effective management of Alzheimer\u2019s disease: a preclinical evidence. Colloids Surf B Biointerfaces 205:111838","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"120604","key":"3507_CR88","doi-asserted-by":"publisher","first-page":"120604","DOI":"10.1016\/j.ijpharm.2021.120604","volume":"602","author":"AH Salama","year":"2021","unstructured":"Salama AH, Salama AAA, Elhabak M (2021) Single step nanospray drying preparation technique of gabapentin-loaded nanoparticles-mediated brain delivery for effective treatment of PTZ-induced seizures. Int J Pharm 602(120604):120604","journal-title":"Int J Pharm"},{"issue":"13","key":"3507_CR89","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1021\/acschemneuro.2c00240","volume":"13","author":"S Saleem","year":"2022","unstructured":"Saleem S, Banerjee R, Rajesh Kannan R (2022) Chrysin-loaded chitosan nanoparticle-mediated neuroprotection in A\u03b21-42-induced neurodegenerative conditions in zebrafish. ACS Chem Neurosci 13(13):2017\u20132034","journal-title":"ACS Chem Neurosci"},{"key":"3507_CR90","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.jddst.2017.11.013","volume":"43","author":"J Sanchez-Ramos","year":"2018","unstructured":"Sanchez-Ramos J, Song S, Kong X, Foroutan P, Martinez G, Dominguez-Viqueria W, Mohapatra S, Mohapatra S, Haraszti RA, Khvorova A, Aronin N, Sava V (2018) Chitosan-Mangafodipir nanoparticles designed for intranasal delivery of siRNA and DNA to brain. J Drug Deliv Sci Technol 43:453\u2013460","journal-title":"J Drug Deliv Sci Technol"},{"key":"3507_CR91","doi-asserted-by":"publisher","first-page":"117907","DOI":"10.1016\/j.carbpol.2021.117907","volume":"262","author":"A Sathiyaseelan","year":"2021","unstructured":"Sathiyaseelan A, Saravanakumar K, Mariadoss AVA, Wang MH (2021) pH-controlled nucleolin targeted release of dual drug from chitosan-gold based aptamer functionalized nano drug delivery system for improved glioblastoma treatment. Carbohyd Polym 262:117907","journal-title":"Carbohyd Polym"},{"issue":"1","key":"3507_CR92","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s11095-017-2324-y","volume":"35","author":"AK Sharma","year":"2018","unstructured":"Sharma AK, Gupta L, Sahu H, Qayum A, Singh SK, Nakhate KT, Ajazuddin, Gupta U (2018) Chitosan engineered PAMAM dendrimers as nanoconstructs for the enhanced anti-cancer potential and improved in vivo brain pharmacokinetics of temozolomide. Pharm Res 35(1):9","journal-title":"Pharm Res"},{"issue":"4","key":"3507_CR93","doi-asserted-by":"publisher","first-page":"538","DOI":"10.2174\/1389201022666210622111028","volume":"23","author":"M Shayganfard","year":"2022","unstructured":"Shayganfard M (2022) A review on chitosan in drug delivery for treatment of neurological and psychiatric disorders. Curr Pharm Biotechnol 23(4):538\u2013551","journal-title":"Curr Pharm Biotechnol"},{"issue":"8","key":"3507_CR94","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.1016\/j.nano.2018.08.004","volume":"14","author":"V Sridhar","year":"2018","unstructured":"Sridhar V, Gaud R, Bajaj A, Wairkar S (2018) Pharmacokinetics and pharmacodynamics of intranasally administered selegiline nanoparticles with improved brain delivery in Parkinson\u2019s disease. Nanomed Nanotechnol Biol Med 14(8):2609\u20132618","journal-title":"Nanomed Nanotechnol Biol Med"},{"issue":"9","key":"3507_CR95","doi-asserted-by":"publisher","first-page":"2801","DOI":"10.3390\/molecules27092801","volume":"27","author":"M Stasi\u0144ska-Jakubas","year":"2022","unstructured":"Stasi\u0144ska-Jakubas M, Hawrylak-Nowak B (2022) Protective, biostimulating, and eliciting effects of chitosan and its derivatives on crop plants. Molecules (Basel Switzerland) 27(9):2801","journal-title":"Molecules (Basel Switzerland)"},{"issue":"5","key":"3507_CR96","first-page":"418","volume":"12","author":"L Sun","year":"2017","unstructured":"Sun L, Chen Y, Zhou Y, Guo D, Fan Y, Guo F, Zheng Y, Chen W (2017) Preparation of 5-fluorouracil-loaded chitosan nanoparticles and study of the sustained release in vitro and in vivo. Asian J Pharm Sci 12(5):418\u2013423","journal-title":"Asian J Pharm Sci"},{"issue":"15","key":"3507_CR97","doi-asserted-by":"publisher","first-page":"18707","DOI":"10.1021\/acsami.3c01421","volume":"15","author":"A Teotia","year":"2023","unstructured":"Teotia A, Laur\u00e9n I, Borandeh S, Sepp\u00e4l\u00e4 J (2023) Quaternized chitosan derivatives as viable antiviral agents: structure\u2013activity correlations and mechanisms of action. ACS Appl Mater Interfaces 15(15):18707\u201318719","journal-title":"ACS Appl Mater Interfaces"},{"issue":"1","key":"3507_CR98","doi-asserted-by":"publisher","first-page":"147","DOI":"10.3390\/pharmaceutics14010147","volume":"14","author":"A Trapani","year":"2022","unstructured":"Trapani A, Cometa S, De Giglio E, Corbo F, Cassano R, Di Gioia ML, Trombino S, Hossain MN, Di Gioia S, Trapani G, Conese M (2022) Novel nanoparticles based on N, O-carboxymethyl chitosan-dopamine amide conjugate for nose-to-brain delivery. Pharmaceutics 14(1):147","journal-title":"Pharmaceutics"},{"key":"3507_CR99","doi-asserted-by":"publisher","first-page":"105149","DOI":"10.1016\/j.jddst.2023.105149","volume":"90","author":"S Trivedi","year":"2023","unstructured":"Trivedi S, Kause S, Belgamwar V (2023) Intranasal delivery of poly (d-glucosamine) encrusted self-assembled lipidic nanovesicles to enhanced brain uptake of thymoquinone for management of Glioblastoma Multiforme. J Drug Deliv Sci Technol 90:105149","journal-title":"J Drug Deliv Sci Technol"},{"issue":"108832","key":"3507_CR100","doi-asserted-by":"publisher","first-page":"108832","DOI":"10.1016\/j.neuropharm.2021.108832","volume":"201","author":"CT Uppuluri","year":"2021","unstructured":"Uppuluri CT, Ravi PR, Dalvi AV (2021) Design and evaluation of thermo-responsive nasal in situ gelling system dispersed with piribedil loaded lecithin-chitosan hybrid nanoparticles for improved brain availability. Neuropharmacology 201(108832):108832","journal-title":"Neuropharmacology"},{"issue":"11","key":"3507_CR101","doi-asserted-by":"publisher","first-page":"4328","DOI":"10.3390\/molecules28114328","volume":"28","author":"N Van Bavel","year":"2023","unstructured":"Van Bavel N, Issler T, Pang L, Anikovskiy M, Prenner EJ (2023) A simple method for synthesis of chitosan nanoparticles with ionic gelation and homogenization. Molecules (Basel, Switzerland) 28(11):4328","journal-title":"Molecules (Basel, Switzerland)"},{"issue":"5","key":"3507_CR102","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/j.nano.2016.02.004","volume":"12","author":"G Wang","year":"2016","unstructured":"Wang G, Wang JJ, Tang XJ, Du L, Li F (2016) In vitro and in vivo evaluation of functionalized chitosan-Pluronic micelles loaded with myricetin on glioblastoma cancer. Nanomed Nanotechnol Biol Med 12(5):1263\u20131278","journal-title":"Nanomed Nanotechnol Biol Med"},{"issue":"8","key":"3507_CR103","doi-asserted-by":"publisher","first-page":"5274","DOI":"10.1166\/jnn.2018.15371","volume":"18","author":"H Wei","year":"2018","unstructured":"Wei H, Lai S, Wei J, Yang L, Jiang N, Wang Q, Yu Y (2018) A novel delivery method of cyclovirobuxine D for brain-targeting: chitosan coated nanoparticles loading cyclovirobuxine D by intranasal administration. J Nanosci Nanotechnol 18(8):5274\u20135282","journal-title":"J Nanosci Nanotechnol"},{"issue":"1","key":"3507_CR104","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.nano.2009.04.001","volume":"6","author":"B Wilson","year":"2010","unstructured":"Wilson B, Samanta MK, Santhi K, Kumar KPS, Ramasamy M, Suresh B (2010) Chitosan nanoparticles as a new delivery system for the anti-Alzheimer drug tacrine. Nanomed Nanotechnol Biol Med 6(1):144\u2013152","journal-title":"Nanomed Nanotechnol Biol Med"},{"key":"3507_CR105","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.carbpol.2018.10.076","volume":"205","author":"P Xie","year":"2019","unstructured":"Xie P, Du P, Li J, Liu P (2019) Stimuli-responsive hybrid cluster bombs of PEGylated chitosan encapsulated DOX-loaded superparamagnetic nanoparticles enabling tumor-specific disassembly for on-demand drug delivery and enhanced MR imaging. Carbohyd Polym 205:377\u2013384","journal-title":"Carbohyd Polym"},{"key":"3507_CR106","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.ijbiomac.2018.02.016","volume":"113","author":"B Xu","year":"2018","unstructured":"Xu B, Zhang W, Chen Y, Xu Y, Wang B, Zong L (2018) Eudragit\u00ae L100-coated mannosylated chitosan nanoparticles for oral protein vaccine delivery. Int J Biol Macromol 113:534\u2013542","journal-title":"Int J Biol Macromol"},{"key":"3507_CR107","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jmst.2019.10.013","volume":"43","author":"Y Xue","year":"2020","unstructured":"Xue Y, Wang N, Zeng Z, Huang J, Xiang Z, Guan Y-Q (2020) Neuroprotective effect of chitosan nanoparticle gene delivery system grafted with acteoside (ACT) in Parkinson\u2019s disease models. J Mater Sci Technol 43:197\u2013207","journal-title":"J Mater Sci Technol"},{"issue":"48","key":"3507_CR108","doi-asserted-by":"publisher","first-page":"28992","DOI":"10.1039\/D0RA04890A","volume":"10","author":"A Yousfan","year":"2020","unstructured":"Yousfan A, Rubio N, Natouf AH, Daher A, Al-Kafry N, Venner K, Kafa H (2020) Preparation and characterisation of PHT-loaded chitosan lecithin nanoparticles for intranasal drug delivery to the brain. RSC Adv 10(48):28992\u201329009","journal-title":"RSC Adv"},{"issue":"4","key":"3507_CR109","doi-asserted-by":"publisher","first-page":"462","DOI":"10.3390\/polym10040462","volume":"10","author":"D Zhao","year":"2018","unstructured":"Zhao D, Yu S, Sun B, Gao S, Guo S, Zhao K (2018) Biomedical applications of chitosan and its derivative nanoparticles. Polymers 10(4):462","journal-title":"Polymers"},{"key":"3507_CR110","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.toxrep.2023.06.012","volume":"11","author":"LH Zoe","year":"2023","unstructured":"Zoe LH, David SR, Rajabalaya R (2023) Chitosan nanoparticle toxicity: a comprehensive literature review of in vivo and in vitro assessments for medical applications. Toxicol Rep 11:83\u2013106","journal-title":"Toxicol Rep"},{"issue":"22","key":"3507_CR111","doi-asserted-by":"publisher","first-page":"5294","DOI":"10.3390\/molecules25225294","volume":"25","author":"Y Zorkina","year":"2020","unstructured":"Zorkina Y, Abramova O, Ushakova V, Morozova A, Zubkov E, Valikhov M, Melnikov P, Majouga A, Chekhonin V (2020) Nano carrier drug delivery systems for the treatment of neuropsychiatric disorders: advantages and limitations. Molecules (Basel Switzerland) 25(22):5294","journal-title":"Molecules (Basel Switzerland)"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03507-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-024-03507-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03507-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T06:48:16Z","timestamp":1742280496000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-024-03507-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,8]]},"references-count":111,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["3507"],"URL":"https:\/\/doi.org\/10.1007\/s00210-024-03507-8","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,8]]},"assertion":[{"value":"12 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}