{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:07:55Z","timestamp":1792782475231,"version":"4.5.0"},"reference-count":142,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Badr University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Gouty arthritis is a prevalent inflammatory illness. Gout attacks begin when there is an imbalance in the body\u2019s uric acid metabolism, which leads to urate buildup and the development of the ailment. A family of conserved, short non-coding RNAs known as microRNAs (miRNAs) can regulate post-transcriptional protein synthesis by attaching to the 3\u2032 untranslated region (UTR) of messenger RNA (mRNA). An increasing amount of research is pointing to miRNAs as potential players in several inflammatory diseases, including gouty arthritis. miRNAs may influence the progression of the disease by regulating immune function and inflammatory responses. This review mainly focused on miRNAs and how they contribute to gouty arthritis. It also looked at how miRNAs could be used as diagnostic, prognostic, and potential therapeutic targets.<\/jats:p>","DOI":"10.1007\/s00210-024-03603-9","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T04:26:00Z","timestamp":1731990360000},"page":"3433-3450","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Unraveling the impact of miRNAs on gouty arthritis: diagnostic significance and therapeutic opportunities"],"prefix":"10.1007","volume":"398","author":[{"given":"Sherif S.","family":"Abdel Mageed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan","family":"Elimam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed E.","family":"Elesawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed I.","family":"Abulsoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Amr","family":"Raouf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manar Mohammed El","family":"Tabaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama A.","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Bakr","family":"Zaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai A.","family":"Abd-Elmawla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walaa A.","family":"El-Dakroury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safwat Abdelhady","family":"Mangoura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud A.","family":"Elrebehy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed S.","family":"Elballal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya A.","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"Ashraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7728-0923","authenticated-orcid":false,"given":"Mustafa Ahmed","family":"Abdel-Reheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali M. S.","family":"Eleragi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein","family":"Abdellatif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0136-7096","authenticated-orcid":false,"given":"Ahmed S.","family":"Doghish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"3603_CR1","doi-asserted-by":"publisher","first-page":"18790","DOI":"10.1038\/s41598-023-45214-z","volume":"13","author":"MA Abd-Elmawla","year":"2023","unstructured":"Abd-Elmawla MA, Elsabagh YA, Aborehab NM (2023a) Association of XIST\/miRNA155\/Gab2\/TAK1 cascade with the pathogenesis of anti-phospholipid syndrome and its effect on cell adhesion molecules and inflammatory mediators. Sci Rep 13:18790","journal-title":"Sci Rep"},{"key":"3603_CR2","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1631\/jzus.B2200385","volume":"24","author":"MA Abd-Elmawla","year":"2023","unstructured":"Abd-Elmawla MA, Ghaiad HR, Gad ES, Ahmed KA, Abdelmonem M (2023b) Suppression of NLRP3 inflammasome by ivermectin ameliorates bleomycin-induced pulmonary fibrosis. J Zhejiang Univ-SCI B 24:723\u2013733","journal-title":"J Zhejiang Univ-SCI B"},{"key":"3603_CR3","doi-asserted-by":"publisher","first-page":"e22899","DOI":"10.1002\/jbt.22899","volume":"35","author":"M Abdelmonem","year":"2021","unstructured":"Abdelmonem M, Ibrahim SM, Essam RM, Amin HAA, Abd-Elmawla MA (2021) Lutein exerts its cardioprotective effect against the experimental model of isoprenaline-induced myocardial infarction via MIAT\/miR-200a\/Nrf2\/TXINP pathway. J Biochem Mol Toxicol 35:e22899","journal-title":"J Biochem Mol Toxicol"},{"key":"3603_CR4","doi-asserted-by":"publisher","first-page":"54","DOI":"10.7861\/clinmedicine.17-1-54","volume":"17","author":"A Abhishek","year":"2017","unstructured":"Abhishek A, Roddy E, Doherty M (2017) Gout\u2013a guide for the general and acute physicians. Clin Med 17:54","journal-title":"Clin Med"},{"key":"3603_CR5","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1038\/labinvest.2011.46","volume":"91","author":"I Allaeys","year":"2011","unstructured":"Allaeys I, Rusu D, Picard S, Pouliot M, Borgeat P, Poubelle PE (2011) Osteoblast retraction induced by adherent neutrophils promotes osteoclast bone resorption: implication for altered bone remodeling in chronic gout. Lab Invest 91:905\u2013920","journal-title":"Lab Invest"},{"key":"3603_CR6","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1093\/rheumatology\/keq204","volume":"49","author":"B \u00c1lvarez-Lario","year":"2010","unstructured":"\u00c1lvarez-Lario B, Macarr\u00f3n-Vicente J (2010) Uric acid and evolution. Rheumatology 49:2010\u20132015","journal-title":"Rheumatology"},{"key":"3603_CR7","doi-asserted-by":"publisher","first-page":"101669","DOI":"10.1016\/j.tice.2021.101669","volume":"73","author":"L An","year":"2021","unstructured":"An L, Yin F (2021) MiR-192-5p suppresses M1 macrophage polarization via epiregulin (EREG) downregulation in gouty arthritis. Tissue Cell 73:101669","journal-title":"Tissue Cell"},{"key":"3603_CR8","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1007\/s00424-018-2190-4","volume":"470","author":"M Auberson","year":"2018","unstructured":"Auberson M, Stadelmann S, Stoudmann C, Seuwen K, Koesters R, Thorens B, Bonny O (2018) SLC2A9 (GLUT9) mediates urate reabsorption in the mouse kidney. Pfl\u00fcgers Archiv-Eur J Physiol 470:1739\u20131751","journal-title":"Pfl\u00fcgers Archiv-Eur J Physiol"},{"key":"3603_CR9","doi-asserted-by":"crossref","unstructured":"Avci \u00c7B, Baran Y (2014) Use of microRNAs in personalized medicine. miRNomics: MicroRNA Biology and Computational Analysis 1107: 311\u2013325","DOI":"10.1007\/978-1-62703-748-8_19"},{"key":"3603_CR10","doi-asserted-by":"publisher","first-page":"2773","DOI":"10.1101\/gad.1705308","volume":"22","author":"JE Babiarz","year":"2008","unstructured":"Babiarz JE, Ruby JG, Wang Y, Bartel DP, Blelloch R (2008) Mouse ES cells express endogenous shRNAs, siRNAs, and other microprocessor-independent, Dicer-dependent small RNAs. Genes Dev 22:2773\u20132785","journal-title":"Genes Dev"},{"key":"3603_CR11","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/s40291-016-0221-4","volume":"20","author":"C Backes","year":"2016","unstructured":"Backes C, Meese E, Keller A (2016) Specific miRNA disease biomarkers in blood, serum and plasma: challenges and prospects. Mol Diagn Ther 20:509\u2013518","journal-title":"Mol Diagn Ther"},{"key":"3603_CR12","doi-asserted-by":"publisher","first-page":"4175","DOI":"10.4049\/jimmunol.1201516","volume":"189","author":"F Bauernfeind","year":"2012","unstructured":"Bauernfeind F, Rieger A, Schildberg FA, Knolle PA, Schmid-Burgk JL, Hornung V (2012) NLRP3 inflammasome activity is negatively controlled by miR-223. J Immunol 189:4175\u20134181","journal-title":"J Immunol"},{"key":"3603_CR13","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/j.jhep.2008.01.035","volume":"48","author":"I Bergheim","year":"2008","unstructured":"Bergheim I, Weber S, Vos M, Kr\u00e4mer S, Volynets V, Kaserouni S, McClain CJ, Bischoff SC (2008) Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin. J Hepatol 48:983\u2013992","journal-title":"J Hepatol"},{"key":"3603_CR14","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1053\/j.ackd.2012.07.009","volume":"19","author":"IA Bobulescu","year":"2012","unstructured":"Bobulescu IA, Moe OW (2012) Renal transport of uric acid: evolving concepts and uncertainties. Adv Chronic Kidney Dis 19:358\u2013371","journal-title":"Adv Chronic Kidney Dis"},{"key":"3603_CR15","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1038\/sj.leu.2402261","volume":"15","author":"A Boer","year":"2001","unstructured":"Boer A, Drayer A, Vellenga E (2001) Effects of overexpression of the SH2-containing inositol phosphatase SHIP on proliferation and apoptosis of erythroid AS-E2 cells. Leukemia 15:1750\u20131757","journal-title":"Leukemia"},{"key":"3603_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13075-021-02569-w","volume":"23","author":"J Bohat\u00e1","year":"2021","unstructured":"Bohat\u00e1 J, Horv\u00e1thov\u00e1 V, Pavl\u00edkov\u00e1 M, Stib\u016frkov\u00e1 B (2021) Circulating microRNA alternations in primary hyperuricemia and gout. Arthritis Res Ther 23:1\u201311","journal-title":"Arthritis Res Ther"},{"key":"3603_CR17","doi-asserted-by":"publisher","first-page":"eabc0221","DOI":"10.1126\/sciadv.abc0221","volume":"6","author":"A Bronisz","year":"2020","unstructured":"Bronisz A, Rooj A, Krawczy\u0144ski K, Peruzzi P, Sali\u0144ska E, Nakano I, Purow B, Chiocca E, Godlewski J (2020) The nuclear DICER\u2013circular RNA complex drives the deregulation of the glioblastoma cell microRNAome. Sci Adv 6:eabc0221","journal-title":"Sci Adv"},{"key":"3603_CR18","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1159\/000479510","volume":"88","author":"S Bussler","year":"2017","unstructured":"Bussler S, Penke M, Flemming G, Elhassan YS, Kratzsch J, Sergeyev E, Lipek T, Vogel M, Spielau U, K\u00f6rner A (2017) Novel insights in the metabolic syndrome in childhood and adolescence. Hormone Res Paediatr 88:181\u2013193","journal-title":"Hormone Res Paediatr"},{"key":"3603_CR19","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S1672-0229(08)60044-3","volume":"7","author":"Y Cai","year":"2009","unstructured":"Cai Y, Yu X, Hu S, Yu J (2009) A brief review on the mechanisms of miRNA regulation. Genomics Proteomics Bioinform 7:147\u2013154","journal-title":"Genomics Proteomics Bioinform"},{"key":"3603_CR20","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1146\/annurev-genom-082410-101446","volume":"12","author":"IS Chan","year":"2011","unstructured":"Chan IS, Ginsburg GS (2011) Personalized medicine: progress and promise. Annu Rev Genomics Hum Genet 12:217\u2013244","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"3603_CR21","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1002\/art.40807","volume":"71","author":"M Chen-Xu","year":"2019","unstructured":"Chen-Xu M, Yokose C, Rai SK, Pillinger MH, Choi HK (2019) Contemporary prevalence of gout and hyperuricemia in the United States and decadal trends: the National Health and Nutrition Examination Survey, 2007\u20132016. Arthritis Rheumatol 71:991\u2013999","journal-title":"Arthritis Rheumatol"},{"key":"3603_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12974-018-1077-9","volume":"15","author":"D Chen","year":"2018","unstructured":"Chen D, Dixon BJ, Doycheva DM, Li B, Zhang Y, Hu Q, He Y, Guo Z, Nowrangi D, Flores J (2018) IRE1\u03b1 inhibition decreased TXNIP\/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic\u2013ischemic brain injury in rats. J Neuroinflammation 15:1\u201318","journal-title":"J Neuroinflammation"},{"issue":"1095\u20131107","key":"3603_CR23","doi-asserted-by":"publisher","first-page":"e1095","DOI":"10.1016\/j.molcel.2017.11.032","volume":"68","author":"GR Chen","year":"2017","unstructured":"Chen GR, Sive H, Bartel DP (2017) A seed mismatch enhances Argonaute2-catalyzed cleavage and partially rescues severely impaired cleavage found in fish. Mol Cell 68(1095\u20131107):e1095","journal-title":"Mol Cell"},{"key":"3603_CR24","unstructured":"Chen X, Gao Q, Zhou L, Wang Y, Sun R-R, Zhang Z-Y (2019) MiR-146a alleviates inflammation of acute gouty arthritis rats through TLR4\/MyD88 signal transduction pathway. Eur Rev Med Pharmacol Sci 23: 1-8"},{"key":"3603_CR25","doi-asserted-by":"publisher","first-page":"11178","DOI":"10.1038\/ncomms11178","volume":"7","author":"J Cheng","year":"2016","unstructured":"Cheng J, Roden CA, Pan W, Zhu S, Baccei A, Pan X, Jiang T, Kluger Y, Weissman SM, Guo S (2016) A Molecular Chipper technology for CRISPR sgRNA library generation and functional mapping of noncoding regions. Nat Commun 7:11178","journal-title":"Nat Commun"},{"key":"3603_CR26","doi-asserted-by":"publisher","first-page":"445","DOI":"10.3899\/jrheum.150738","volume":"43","author":"A Chhana","year":"2016","unstructured":"Chhana A, Aati O, Gamble GD, Callon KE, Doyle AJ, Roger M, McQueen FM, Horne A, Reid IR, Cornish J (2016) Path analysis identifies receptor activator of nuclear factor-\u03baB ligand, osteoprotegerin, and sclerostin as potential mediators of the tophus-bone erosion relationship in gout. J Rheumatol 43:445\u2013449","journal-title":"J Rheumatol"},{"key":"3603_CR27","doi-asserted-by":"publisher","first-page":"499","DOI":"10.7326\/0003-4819-143-7-200510040-00009","volume":"143","author":"HK Choi","year":"2005","unstructured":"Choi HK, Mount DB, Reginato AM (2005) Pathogenesis of gout. Ann Intern Med 143:499\u2013516","journal-title":"Ann Intern Med"},{"key":"3603_CR28","doi-asserted-by":"publisher","first-page":"626","DOI":"10.3389\/fgene.2019.00626","volume":"10","author":"M Cui","year":"2019","unstructured":"Cui M, Wang H, Yao X, Zhang D, Xie Y, Cui R, Zhang X (2019) Circulating microRNAs in cancer: potential and challenge. Front Genet 10:626","journal-title":"Front Genet"},{"key":"3603_CR29","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780198748311.001.0001","volume-title":"Gout","author":"N Dalbeth","year":"2016","unstructured":"Dalbeth N, Stamp L, Merriman T (2016) Gout. Oxford University Press"},{"key":"3603_CR30","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nature03049","volume":"432","author":"AM Denli","year":"2004","unstructured":"Denli AM, Tops BB, Plasterk RH, Ketting RF, Hannon GJ (2004) Processing of primary microRNAs by the microprocessor complex. Nature 432:231\u2013235","journal-title":"Nature"},{"key":"3603_CR31","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1093\/abbs\/gmz110","volume":"51","author":"G Dong","year":"2019","unstructured":"Dong G, Pan T, Zhou D, Li C, Liu J, Zhang J (2019) FBXL19-AS1 promotes cell proliferation and inhibits cell apoptosis via miR-876-5p\/FOXM1 axis in breast cancer. Acta Biochim Biophys Sin 51:1106\u20131113","journal-title":"Acta Biochim Biophys Sin"},{"key":"3603_CR32","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.2217\/pgs.12.147","volume":"13","author":"E Dreussi","year":"2012","unstructured":"Dreussi E, Biason P, Toffoli G, Cecchin E (2012) miRNA pharmacogenomics: the new frontier for personalized medicine in cancer? Pharmacogenomics 13:1635\u20131650","journal-title":"Pharmacogenomics"},{"key":"3603_CR33","doi-asserted-by":"publisher","first-page":"18457","DOI":"10.1002\/jcb.29163","volume":"120","author":"J Du","year":"2019","unstructured":"Du J, Chen M, Liu J, Hu P, Guan H, Jiao X (2019) LncRNA F11-AS1 suppresses liver hepatocellular carcinoma progression by competitively binding with miR-3146 to regulate PTEN expression. J Cell Biochem 120:18457\u201318464","journal-title":"J Cell Biochem"},{"key":"3603_CR34","doi-asserted-by":"publisher","first-page":"110541","DOI":"10.1016\/j.intimp.2023.110541","volume":"121","author":"NA El-Boghdady","year":"2023","unstructured":"El-Boghdady NA, Abd El-Hakk S, Abd-Elmawla MA (2023) The lncRNAs UCA1 and CRNDE target miR-145\/TLR4\/NF-\u049bB\/TNF-\u03b1 axis in acetic acid-induced ulcerative colitis model: The beneficial role of 3, 3-diindolylmethane. Int Immunopharmacol 121:110541","journal-title":"Int Immunopharmacol"},{"key":"3603_CR35","doi-asserted-by":"publisher","first-page":"155093","DOI":"10.1016\/j.prp.2024.155093","volume":"253","author":"MS Elballal","year":"2024","unstructured":"Elballal MS, Mohammed OA, Zaki MB, Abulsoud AI, El Tabaa MM, Elazazy O, Abd-Elmawla MA, El-Dakroury WA, Mageed SSA, Rashad AA (2024) miRNAs as modulators of neuroinflammation and excitotoxicity: implications for stroke therapeutics. Pathol Res Pract 253:155093","journal-title":"Pathol Res Pract"},{"key":"3603_CR36","doi-asserted-by":"publisher","first-page":"120751","DOI":"10.1016\/j.lfs.2022.120751","volume":"305","author":"MM Elseweidy","year":"2022","unstructured":"Elseweidy MM, Elesawy AE, Sobh MS, Elnagar GM (2022) Ellagic acid ameliorates high fructose-induced hyperuricemia and non-alcoholic fatty liver in Wistar rats: focusing on the role of C1q\/tumor necrosis factor-related protein-3 and ATP citrate lyase. Life Sci 305:120751","journal-title":"Life Sci"},{"key":"3603_CR37","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s10157-005-0368-5","volume":"9","author":"A Enomoto","year":"2005","unstructured":"Enomoto A, Endou H (2005) Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human disease. Clin Exp Nephrol 9:195\u2013205","journal-title":"Clin Exp Nephrol"},{"key":"3603_CR38","doi-asserted-by":"crossref","unstructured":"Ergin K, \u00c7etinkaya R (2022) Regulation of microRNAs. miRNomics. Springer, pp. 1\u201332","DOI":"10.1007\/978-1-0716-1170-8_1"},{"key":"3603_CR39","doi-asserted-by":"publisher","unstructured":"Erturk E, Onur OE, Akgun O, Tuna GP, Yildiz Y, Ari F (2022) Mitochondrial miRNAs (mitomiRs): Their potential roles in breast and other cancers. Mitochondrion. https:\/\/doi.org\/10.1016\/j.mito.2022.08.002","DOI":"10.1016\/j.mito.2022.08.002"},{"key":"3603_CR40","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.1002\/acr.23549","volume":"70","author":"IO Estevez-Garcia","year":"2018","unstructured":"Estevez-Garcia IO, Gallegos-Nava S, Vera-P\u00e9rez E, Silveira LH, Ventura-R\u00edos L, Vancini G, Hern\u00e1ndez-D\u00edaz C, S\u00e1nchez-Mu\u00f1oz F, Ballinas-Verdugo MA, Gutierrez M (2018) Levels of cytokines and micro RNA s in individuals with asymptomatic hyperuricemia and ultrasonographic findings of gout: a bench-to-bedside approach. Arthritis Care Res 70:1814\u20131821","journal-title":"Arthritis Care Res"},{"key":"3603_CR41","doi-asserted-by":"publisher","unstructured":"Fisher MC, Rai SK, Lu N, Zhang Y, Choi HK (2017) The unclosing premature mortality gap in gout: a general population-based study. Annals of the rheumatic diseases: annrheumdis. https:\/\/doi.org\/10.1136\/annrheumdis-2016-210588","DOI":"10.1136\/annrheumdis-2016-210588"},{"key":"3603_CR42","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1002\/acr.24180","volume":"72","author":"JD FitzGerald","year":"2020","unstructured":"FitzGerald JD, Dalbeth N, Mikuls T, Brignardello-Petersen R, Guyatt G, Abeles AM, Gelber AC, Harrold LR, Khanna D, King C (2020) 2020 American College of Rheumatology guideline for the management of gout. Arthritis Care Res 72:744\u2013760","journal-title":"Arthritis Care Res"},{"key":"3603_CR43","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1007\/s12094-019-02210-y","volume":"22","author":"J Ghizoni","year":"2020","unstructured":"Ghizoni J, Nichele R, De Oliveira M, Pamato S, Pereira J (2020) The utilization of saliva as an early diagnostic tool for oral cancer: microRNA as a biomarker. Clin Transl Oncol 22:804\u2013812","journal-title":"Clin Transl Oncol"},{"key":"3603_CR44","doi-asserted-by":"publisher","first-page":"6874","DOI":"10.1093\/nar\/gkaa386","volume":"48","author":"G Grasso","year":"2020","unstructured":"Grasso G, Higuchi T, Mac V, Barbier J, Helsmoortel M, Lorenzi C, Sanchez G, Bello M, Ritchie W, Sakamoto S (2020) NF90 modulates processing of a subset of human pri-miRNAs. Nucleic Acids Res 48:6874\u20136888","journal-title":"Nucleic Acids Res"},{"key":"3603_CR45","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.yexcr.2017.03.039","volume":"354","author":"X Gu","year":"2017","unstructured":"Gu X, Gao Y, Mu D-G, Fu E-Q (2017) MiR-23a-5p modulates mycobacterial survival and autophagy during mycobacterium tuberculosis infection through TLR2\/MyD88\/NF-\u03baB pathway by targeting TLR2. Exp Cell Res 354:71\u201377","journal-title":"Exp Cell Res"},{"key":"3603_CR46","first-page":"113","volume":"28","author":"A Gupta","year":"2019","unstructured":"Gupta A, Elfiky A (2019) Novel findings from determination of common expressed plasma exosomal microRNAs in patients with psoriatic arthritis, psoriasis vulgaris, rheumatoid arthritis, and gouty arthritis. Discov Med 28:113\u2013122","journal-title":"Discov Med"},{"key":"3603_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2369-14-164","volume":"14","author":"D Gustafsson","year":"2013","unstructured":"Gustafsson D, Unwin R (2013) The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality. BMC Nephrol 14:1\u20139","journal-title":"BMC Nephrol"},{"key":"3603_CR48","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1111\/joim.12099","volume":"274","author":"M Haneklaus","year":"2013","unstructured":"Haneklaus M, Gerlic M, O\u2019Neill LA, Masters S (2013) miR-223: infection, inflammation and cancer. J Intern Med 274:215\u2013226","journal-title":"J Intern Med"},{"key":"3603_CR49","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1038\/nature03552","volume":"435","author":"L He","year":"2005","unstructured":"He L, Thomson JM, Hemann MT, Hernando-Monge E, Mu D, Goodson S, Powers S, Cordon-Cardo C, Lowe SW, Hannon GJ (2005) A microRNA polycistron as a potential human oncogene. Nature 435:828\u2013833","journal-title":"Nature"},{"key":"3603_CR50","doi-asserted-by":"publisher","first-page":"4601959","DOI":"10.1155\/2017\/4601959","volume":"2017","author":"Q He","year":"2017","unstructured":"He Q, Sun C, Lei W, Ma J (2017) SOCS1 regulates apoptosis and inflammation by inhibiting IL-4 signaling in IL-1\u03b2-stimulated human osteoarthritic chondrocytes. Biomed Res Int 2017:4601959","journal-title":"Biomed Res Int"},{"key":"3603_CR51","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","volume":"41","author":"Y He","year":"2016","unstructured":"He Y, Hara H, N\u00fa\u00f1ez G (2016) Mechanism and regulation of NLRP3 inflammasome activation. Trends Biochem Sci 41:1012\u20131021","journal-title":"Trends Biochem Sci"},{"key":"3603_CR52","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s40610-019-0116-3","volume":"5","author":"HC Hrdlicka","year":"2019","unstructured":"Hrdlicka HC, Lee S-K, Delany AM (2019) MicroRNAs are critical regulators of osteoclast differentiation. Curr Mol Biol Rep 5:65\u201374","journal-title":"Curr Mol Biol Rep"},{"key":"3603_CR53","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1038\/ncomms1756","volume":"3","author":"K Ichida","year":"2012","unstructured":"Ichida K, Matsuo H, Takada T, Nakayama A, Murakami K, Shimizu T, Yamanashi Y, Kasuga H, Nakashima H, Nakamura T (2012) Decreased extra-renal urate excretion is a common cause of hyperuricemia. Nat Commun 3:764","journal-title":"Nat Commun"},{"key":"3603_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12964-022-01019-7","volume":"21","author":"A \u0130lhan","year":"2023","unstructured":"\u0130lhan A, Golestani S, Shafagh SG, Asadi F, Daneshdoust D, Al-Naqeeb BZT, Nemati MM, Khalatbari F, Yaseri AF (2023) The dual role of microRNA (miR)-20b in cancers: friend or foe? Cell Commun Signal 21:1\u201313","journal-title":"Cell Commun Signal"},{"key":"3603_CR55","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s43094-024-00640-2","volume":"10","author":"SM Ismail","year":"2024","unstructured":"Ismail SM, Abd-Elmawla MA, Shabayek MI, Darwish HA, El-Sawalhi MM (2024) The role of LncRNAs and CircRNAs in osteoporosis: a focus on osteogenesis and osteoclastogenesis signaling pathways. Fut J Pharm Sci 10:64","journal-title":"Fut J Pharm Sci"},{"key":"3603_CR56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/ar4531","volume":"16","author":"HM Jin","year":"2014","unstructured":"Jin HM, Kim T-J, Choi J-H, Kim M-J, Cho Y-N, Nam K-I, Kee S-J, Moon JB, Choi S-Y, Park D-J (2014) MicroRNA-155 as a proinflammatory regulator via SHIP-1 down-regulation in acute gouty arthritis. Arthritis Res Ther 16:1\u20139","journal-title":"Arthritis Res Ther"},{"key":"3603_CR57","doi-asserted-by":"crossref","unstructured":"Johnson RJ, Titte S, Cade JR, Rideout BA, Oliver WJ (2005) Uric acid, evolution and primitive cultures. Seminars in nephrology. Elsevier, pp. 3\u20138","DOI":"10.1016\/j.semnephrol.2004.09.002"},{"key":"3603_CR58","doi-asserted-by":"publisher","first-page":"4737","DOI":"10.4049\/jimmunol.168.9.4737","volume":"168","author":"J Kalesnikoff","year":"2002","unstructured":"Kalesnikoff J, Baur N, Leitges M, Hughes MR, Damen JE, Huber M, Krystal G (2002) SHIP negatively regulates IgE+ antigen-induced IL-6 production in mast cells by inhibiting NF-\u03baB activity. J Immunol 168:4737\u20134746","journal-title":"J Immunol"},{"key":"3603_CR59","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1080\/15257770.2011.596498","volume":"30","author":"A Kanbara","year":"2011","unstructured":"Kanbara A, Seyama I (2011) Effect of urine pH on uric acid excretion by manipulating food materials. Nucleosides Nucleotides Nucleic Acids 30:1066\u20131071","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"3603_CR60","doi-asserted-by":"crossref","unstructured":"Kawai T, Akira S (2007) TLR signaling. Seminars in immunology. Elsevier, pp. 24\u201332","DOI":"10.1016\/j.smim.2006.12.004"},{"key":"3603_CR61","doi-asserted-by":"publisher","first-page":"3328","DOI":"10.3390\/ijms20133328","volume":"20","author":"N Kelley","year":"2019","unstructured":"Kelley N, Jeltema D, Duan Y, He Y (2019) The NLRP3 inflammasome: an overview of mechanisms of activation and regulation. Int J Mol Sci 20:3328","journal-title":"Int J Mol Sci"},{"key":"3603_CR62","first-page":"921","volume":"35","author":"X Kong","year":"2021","unstructured":"Kong X, Shi S, Hu H, Wang J (2021) MicroRNA-20a suppresses RANKL-modulated osteoclastogenesis and prevents bone erosion in mice with rheumatoid arthritis through the TLR4\/p38 pathway. J Biol Regul Homeost Agents 35:921\u2013931","journal-title":"J Biol Regul Homeost Agents"},{"key":"3603_CR63","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1021\/acschemneuro.2c00653","volume":"14","author":"MA Kortam","year":"2023","unstructured":"Kortam MA, Elfar N, Shaker OG, El-Boghdady NA, Abd-Elmawla MA (2023) MAGI2-AS3 and miR-374b-5p as putative regulators of multiple sclerosis via modulating the PTEN\/AKT\/IRF-3\/IFN-\u03b2 Axis: new clinical insights. ACS Chem Neurosci 14:1107\u20131118","journal-title":"ACS Chem Neurosci"},{"key":"3603_CR64","doi-asserted-by":"publisher","first-page":"3763","DOI":"10.1073\/pnas.1320393111","volume":"111","author":"JT Kratzer","year":"2014","unstructured":"Kratzer JT, Lanaspa MA, Murphy MN, Cicerchi C, Graves CL, Tipton PA, Ortlund EA, Johnson RJ, Gaucher EA (2014) Evolutionary history and metabolic insights of ancient mammalian uricases. Proc Natl Acad Sci 111:3763\u20133768","journal-title":"Proc Natl Acad Sci"},{"key":"3603_CR65","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.jfma.2018.04.013","volume":"118","author":"G Kuo","year":"2019","unstructured":"Kuo G, Wu C-Y, Yang H-Y (2019) MiR-17-92 cluster and immunity. J Formos Med Assoc 118:2\u20136","journal-title":"J Formos Med Assoc"},{"key":"3603_CR66","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.2217\/pgs-2019-0089","volume":"20","author":"A Latini","year":"2019","unstructured":"Latini A, Borgiani P, Novelli G, Ciccacci C (2019) miRNAs in drug response variability: potential utility as biomarkers for personalized medicine. Pharmacogenomics 20:1049\u20131059","journal-title":"Pharmacogenomics"},{"key":"3603_CR67","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.cmet.2012.07.007","volume":"16","author":"AG Lerner","year":"2012","unstructured":"Lerner AG, Upton J-P, Praveen P, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M (2012) IRE1\u03b1 induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab 16:250\u2013264","journal-title":"Cell Metab"},{"key":"3603_CR68","doi-asserted-by":"publisher","first-page":"106382","DOI":"10.1016\/j.compbiomed.2022.106382","volume":"152","author":"C Li","year":"2022","unstructured":"Li C, Dou P, Wang T, Lu X, Xu G, Lin X (2022a) Defining disease-related modules based on weighted miRNA synergistic network. Comput Biol Med 152:106382","journal-title":"Comput Biol Med"},{"key":"3603_CR69","doi-asserted-by":"publisher","first-page":"536","DOI":"10.46497\/ArchRheumatol.2022.9236","volume":"37","author":"F Li","year":"2022","unstructured":"Li F, Yao J-H, Li L, Nie Q, Cao J-J, Ning X-R (2022b) MiRNA-23a-5p is the biomarkers for gouty arthritis and promotes inflammation in rats of gouty arthritis via MyD88\/NF-\u03baB pathway by induction TLR2. Archives of Rheumatology 37:536","journal-title":"Archives of Rheumatology"},{"key":"3603_CR70","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1111\/1756-185X.14028","volume":"24","author":"G Li","year":"2021","unstructured":"Li G, Zhang H, Ma H, Qu S, Xing Q, Wang G (2021) MiR-221-5p is involved in the regulation of inflammatory responses in acute gouty arthritis by targeting IL-1\u03b2. Int J Rheum Dis 24:335\u2013340","journal-title":"Int J Rheum Dis"},{"key":"3603_CR71","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.lfs.2018.07.057","volume":"209","author":"Z Li","year":"2018","unstructured":"Li Z, Zhou L, Lin C, Pan X, Xie J, Zhao L, Quan J, Xu J, Guan X, Xu W (2018) MiR-302b regulates cell functions and acts as a potential biomarker to predict recurrence in bladder cancer. Life Sci 209:15\u201323","journal-title":"Life Sci"},{"key":"3603_CR72","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1007\/s10753-021-01483-2","volume":"44","author":"C Lian","year":"2021","unstructured":"Lian C, Sun J, Guan W, Zhang L, Zhang X, Yang L, Hu W (2021) Circular RNA circHIPK3 activates macrophage NLRP3 inflammasome and TLR4 pathway in gouty arthritis via sponging miR-561 and miR-192. Inflammation 44:2065\u20132077","journal-title":"Inflammation"},{"key":"3603_CR73","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1093\/rheumatology\/kez165","volume":"58","author":"L Liu","year":"2019","unstructured":"Liu L, Zhu X, Zhao T, Yu Y, Xue Y, Zou H (2019) Sirt1 ameliorates monosodium urate crystal\u2013induced inflammation by altering macrophage polarization via the PI3K\/Akt\/STAT6 pathway. Rheumatology 58:1674\u20131683","journal-title":"Rheumatology"},{"key":"3603_CR74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40001-020-00404-7","volume":"25","author":"R Liu","year":"2020","unstructured":"Liu R, Yang L, Wei Q (2020) miR-34a targets PAI-1 to regulate urinary microalbumin and renal function in hypertensive mice. Eur J Med Res 25:1\u20139","journal-title":"Eur J Med Res"},{"key":"3603_CR75","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1080\/15384101.2021.1874696","volume":"20","author":"Y-F Liu","year":"2021","unstructured":"Liu Y-F, Xing G-L, Chen Z, Tu S-H (2021) Long non-coding RNA HOTAIR knockdown alleviates gouty arthritis through miR-20b upregulation and NLRP3 downregulation. Cell Cycle 20:332\u2013344","journal-title":"Cell Cycle"},{"key":"3603_CR76","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1002\/art.1780150209","volume":"15","author":"JN Loeb","year":"1972","unstructured":"Loeb JN (1972) The influence of temperature on the solubility of monosodium urate. Arthritis Rheum 15:189\u2013192","journal-title":"Arthritis Rheum"},{"key":"3603_CR77","doi-asserted-by":"publisher","first-page":"E1106","DOI":"10.1073\/pnas.1420955112","volume":"112","author":"E Londin","year":"2015","unstructured":"Londin E, Loher P, Telonis AG, Quann K, Clark P, Jing Y, Hatzimichael E, Kirino Y, Honda S, Lally M (2015) Analysis of 13 cell types reveals evidence for the expression of numerous novel primate-and tissue-specific microRNAs. Proc Natl Acad Sci 112:E1106\u2013E1115","journal-title":"Proc Natl Acad Sci"},{"key":"3603_CR78","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1080\/15384101.2022.2031678","volume":"21","author":"Y Lu","year":"2022","unstructured":"Lu Y, Fang L, Xu X, Wu Y, Li J (2022) MicroRNA-142-3p facilitates inflammatory response by targeting ZEB2 and activating NF-\u03baB signaling in gouty arthritis. Cell Cycle 21:805\u2013819","journal-title":"Cell Cycle"},{"key":"3603_CR79","doi-asserted-by":"publisher","first-page":"967769","DOI":"10.3389\/fendo.2022.967769","volume":"13","author":"Z Luo","year":"2022","unstructured":"Luo Z, Yang F, Hong S, Wang J, Chen B, Li L, Yang J, Yao Y, Yang C, Hu Y (2022) Role of microRNA alternation in the pathogenesis of gouty arthritis. Front Endocrinol 13:967769","journal-title":"Front Endocrinol"},{"key":"3603_CR80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13075-018-1528-9","volume":"20","author":"T Ma","year":"2018","unstructured":"Ma T, Liu X, Cen Z, Xin C, Guo M, Zou C, Song W, Xie R, Wang K, Zhou H (2018) MicroRNA-302b negatively regulates IL-1\u03b2 production in response to MSU crystals by targeting IRAK4 and EphA2. Arthritis Res Ther 20:1\u201311","journal-title":"Arthritis Res Ther"},{"key":"3603_CR81","doi-asserted-by":"publisher","first-page":"623","DOI":"10.2217\/bmm.13.44","volume":"7","author":"C Mall","year":"2013","unstructured":"Mall C, Rocke DM, Durbin-Johnson B, Weiss RH (2013) Stability of miRNA in human urine supports its biomarker potential. Biomark Med 7:623\u2013631","journal-title":"Biomark Med"},{"key":"3603_CR82","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1146\/annurev-physiol-021113-170343","volume":"77","author":"AK Mandal","year":"2015","unstructured":"Mandal AK, Mount DB (2015) The molecular physiology of uric acid homeostasis. Annu Rev Physiol 77:323\u2013345","journal-title":"Annu Rev Physiol"},{"key":"3603_CR83","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/gene.2014.9","volume":"15","author":"MJ Maxwell","year":"2014","unstructured":"Maxwell MJ, Srivastava N, Park MY, Tsantikos E, Engelman RW, Kerr WG, Hibbs M (2014) SHIP-1 deficiency in the myeloid compartment is insufficient to induce myeloid expansion or chronic inflammation. Genes Immun 15:233\u2013240","journal-title":"Genes Immun"},{"key":"3603_CR84","doi-asserted-by":"publisher","first-page":"111413","DOI":"10.1016\/j.biopha.2021.111413","volume":"138","author":"Q Meng","year":"2021","unstructured":"Meng Q, Meng W, Bian H, Zheng F, Gu H, Zuo R, Miao X, Zhou Z, Wang L, Wen Z (2021) Total glucosides of paeony protects THP-1 macrophages against monosodium urate-induced inflammation via MALAT1\/miR-876-5p\/NLRP3 signaling cascade in gouty arthritis. Biomed Pharmacother 138:111413","journal-title":"Biomed Pharmacother"},{"key":"3603_CR85","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/ar4282","volume":"15","author":"F Mizoguchi","year":"2013","unstructured":"Mizoguchi F, Murakami Y, Saito T, Miyasaka N, Kohsaka H (2013) miR-31 controls osteoclast formation and bone resorption by targeting RhoA. Arthritis Res Ther 15:1\u20137","journal-title":"Arthritis Res Ther"},{"key":"3603_CR86","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1002\/art.41441","volume":"72","author":"A Najm","year":"2020","unstructured":"Najm A, Masson FM, Preuss P, Georges S, Ory B, Quillard T, Sood S, Goodyear CS, Veale DJ, Fearon U (2020) MicroRNA-17-5p reduces inflammation and bone erosions in mice with collagen-induced arthritis and directly targets the JAK\/STAT pathway in rheumatoid arthritis fibroblast-like synoviocytes. Arthritis Rheumatol 72:2030\u20132039","journal-title":"Arthritis Rheumatol"},{"key":"3603_CR87","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1084\/jem.20160462","volume":"214","author":"V Neudecker","year":"2017","unstructured":"Neudecker V, Haneklaus M, Jensen O, Khailova L, Masterson JC, Tye H, Biette K, Jedlicka P, Brodsky KS, Gerich ME (2017) Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome. J Exp Med 214:1737\u20131752","journal-title":"J Exp Med"},{"key":"3603_CR88","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1101\/gad.1919710","volume":"24","author":"MA Newman","year":"2010","unstructured":"Newman MA, Hammond SM (2010) Emerging paradigms of regulated microRNA processing. Genes Dev 24:1086\u20131092","journal-title":"Genes Dev"},{"key":"3603_CR89","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.yexcr.2018.07.044","volume":"371","author":"KO Nielsen","year":"2018","unstructured":"Nielsen KO, Jacobsen KS, Mirza AH, Winther TN, St\u00f8rling J, Glebe D, Pociot F, Hogh B (2018) Hepatitis B virus upregulates host microRNAs that target apoptosis-regulatory genes in an in vitro cell model. Exp Cell Res 371:92\u2013103","journal-title":"Exp Cell Res"},{"key":"3603_CR90","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1002\/jcp.21993","volume":"222","author":"AF Olena","year":"2010","unstructured":"Olena AF, Patton JG (2010) Genomic organization of microRNAs. J Cell Physiol 222:540\u2013545","journal-title":"J Cell Physiol"},{"key":"3603_CR91","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3390\/biom6040044","volume":"6","author":"P Papanagnou","year":"2016","unstructured":"Papanagnou P, Stivarou T, Tsironi M (2016) The role of miRNAs in common inflammatory arthropathies: osteoarthritis and gouty arthritis. Biomolecules 6:44","journal-title":"Biomolecules"},{"key":"3603_CR92","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1080\/14656566.2017.1351945","volume":"18","author":"T Pascart","year":"2017","unstructured":"Pascart T, Richette P (2017) Current and future therapies for gout. Expert Opin Pharmacother 18:1201\u20131211","journal-title":"Expert Opin Pharmacother"},{"key":"3603_CR93","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/s12041-008-0073-8","volume":"87","author":"M Pegoraro","year":"2008","unstructured":"Pegoraro M, Tauber E (2008) The role of microRNAs (miRNA) in circadian rhythmicity. J Genet 87:505\u2013511","journal-title":"J Genet"},{"key":"3603_CR94","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41413-023-00244-1","volume":"11","author":"X Peng","year":"2023","unstructured":"Peng X, Wang Q, Li W, Ge G, Peng J, Xu Y, Yang H, Bai J, Geng D (2023) Comprehensive overview of microRNA function in rheumatoid arthritis. Bone Res 11:8","journal-title":"Bone Res"},{"key":"3603_CR95","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1177\/1759720X15599734","volume":"7","author":"F Perez-Ruiz","year":"2015","unstructured":"Perez-Ruiz F, Marimon E, Chinchilla SP (2015) Hyperuricaemia with deposition: latest evidence and therapeutic approach. Ther Adv Musculoskelet Dis 7:225\u2013233","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"3603_CR96","doi-asserted-by":"crossref","unstructured":"Qin H, Yang Q, Wang T, Liu L, Di C, Zhuang Q, Xiao L, Yin H (2020) lncRNA F11-AS1 Suppresses Glioma by Regulation miRNA-3146\/PTEN. Res Sq 2020: 1-26","DOI":"10.21203\/rs.3.rs-46084\/v1"},{"key":"3603_CR97","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.3892\/mmr.2017.6829","volume":"16","author":"J Quan","year":"2017","unstructured":"Quan J, Jin L, Pan X, He T, Lai Y, Chen P, Lin C, Yang S, Zeng H, Lai Y (2017) Oncogenic miR-23a-5p is associated with cellular function in RCC. Mol Med Rep 16:2309\u20132317","journal-title":"Mol Med Rep"},{"key":"3603_CR98","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.jare.2017.04.008","volume":"8","author":"G Ragab","year":"2017","unstructured":"Ragab G, Elshahaly M, Bardin T (2017) Gout: An old disease in new perspective\u2013a review. J Adv Res 8:495\u2013511","journal-title":"J Adv Res"},{"key":"3603_CR99","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1007\/s11926-022-01069-3","volume":"24","author":"GK Ramos","year":"2022","unstructured":"Ramos GK, Goldfarb DS (2022) Update on uric acid and the kidney. Curr Rheumatol Rep 24:132\u2013138","journal-title":"Curr Rheumatol Rep"},{"key":"3603_CR100","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1136\/annrheumdis-2016-209707","volume":"76","author":"P Richette","year":"2017","unstructured":"Richette P, Doherty M, Pascual E, Barskova V, Becce F, Casta\u00f1eda-Sanabria J, Coyfish M, Guillo S, Jansen T, Janssens H (2017) 2016 updated EULAR evidence-based recommendations for the management of gout. Ann Rheum Dis 76:29\u201342","journal-title":"Ann Rheum Dis"},{"key":"3603_CR101","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1101\/gr.2722704","volume":"14","author":"A Rodriguez","year":"2004","unstructured":"Rodriguez A, Griffiths-Jones S, Ashurst JL, Bradley A (2004) Identification of mammalian microRNA host genes and transcription units. Genome Res 14:1902\u20131910","journal-title":"Genome Res"},{"key":"3603_CR102","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1002\/jcp.24306","volume":"228","author":"M Rossi","year":"2013","unstructured":"Rossi M, Pitari MR, Amodio N, Di Martino MT, Conforti F, Leone E, Botta C, Paolino FM, Del Giudice T, Iuliano E (2013) miR-29b negatively regulates human osteoclastic cell differentiation and function: implications for the treatment of multiple myeloma-related bone disease. J Cell Physiol 228:1506\u20131515","journal-title":"J Cell Physiol"},{"key":"3603_CR103","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13075-015-0610-9","volume":"17","author":"MJ Roughley","year":"2015","unstructured":"Roughley MJ, Belcher J, Mallen CD, Roddy E (2015) Gout and risk of chronic kidney disease and nephrolithiasis: meta-analysis of observational studies. Arthritis Res Ther 17:1\u201312","journal-title":"Arthritis Res Ther"},{"key":"3603_CR104","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/nature05983","volume":"448","author":"JG Ruby","year":"2007","unstructured":"Ruby JG, Jan CH, Bartel DP (2007) Intronic microRNA precursors that bypass Drosha processing. Nature 448:83\u201386","journal-title":"Nature"},{"key":"3603_CR105","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1002\/path.2264","volume":"214","author":"I Sabroe","year":"2008","unstructured":"Sabroe I, Parker L, Dower S, Whyte M (2008) The role of TLR activation in inflammation. J Pathol 214:126\u2013135","journal-title":"J Pathol"},{"key":"3603_CR106","doi-asserted-by":"publisher","unstructured":"Salman A, Mageed SSA, Fathi D, Elrebehy MA, Abulsoud AI, Elshaer SS, Khidr EG, Al-Noshokaty TM, Khaled R, Rizk NI (2023) Deciphering signaling pathway interplay via miRNAs in malignant pleural mesothelioma. Pathol-Res Pract. 154947. https:\/\/doi.org\/10.1016\/j.prp.2023.154947","DOI":"10.1016\/j.prp.2023.154947"},{"key":"3603_CR107","doi-asserted-by":"publisher","first-page":"e24032","DOI":"10.1002\/jcla.24032","volume":"35","author":"L Shan","year":"2021","unstructured":"Shan L, Yang D, Feng F, Zhu D, Li X (2021) miR-3146 induces neutrophil extracellular traps to aggravate gout flare. J Clin Lab Anal 35:e24032","journal-title":"J Clin Lab Anal"},{"key":"3603_CR108","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/s41576-023-00611-y","volume":"24","author":"R Shang","year":"2023","unstructured":"Shang R, Lee S, Senavirathne G, Lai EC (2023) microRNAs in action: biogenesis, function and regulation. Nat Rev Genet 24:816\u2013833","journal-title":"Nat Rev Genet"},{"key":"3603_CR109","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/bs.apcsb.2023.02.004","volume":"137","author":"I \u0160krlec","year":"2023","unstructured":"\u0160krlec I (2023) Circadian system microRNAs\u2013role in the development of cardiovascular diseases. Adv Protein Chem Struct Biol 137:225\u2013267","journal-title":"Adv Protein Chem Struct Biol"},{"key":"3603_CR110","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/nrrheum.2017.155","volume":"13","author":"AK So","year":"2017","unstructured":"So AK, Martinon F (2017) Inflammation in gout: mechanisms and therapeutic targets. Nat Rev Rheumatol 13:639\u2013647","journal-title":"Nat Rev Rheumatol"},{"key":"3603_CR111","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1423-0127-20-31","volume":"20","author":"J Song","year":"2013","unstructured":"Song J, Kim D, Lee CH, Lee MS, Chun C-H, Jin E-J (2013) MicroRNA-488 regulates zinc transporter SLC39A8\/ZIP8 during pathogenesis of osteoarthritis. J Biomed Sci 20:1\u20136","journal-title":"J Biomed Sci"},{"key":"3603_CR112","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.ejpb.2020.02.007","volume":"149","author":"S Sujitha","year":"2020","unstructured":"Sujitha S, Dinesh P, Rasool M (2020) Berberine encapsulated PEG-coated liposomes attenuate Wnt1\/\u03b2-catenin signaling in rheumatoid arthritis via miR-23a activation. Eur J Pharm Biopharm 149:170\u2013191","journal-title":"Eur J Pharm Biopharm"},{"key":"3603_CR113","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1177\/1535370220908041","volume":"245","author":"F Sun","year":"2020","unstructured":"Sun F, Yuan W, Wu H, Chen G, Sun Y, Yuan L, Zhang W, Lei M (2020) LncRNA KCNQ1OT1 attenuates sepsis-induced myocardial injury via regulating miR-192-5p\/XIAP axis. Exp Biol Med 245:620\u2013630","journal-title":"Exp Biol Med"},{"key":"3603_CR114","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s11655-011-0605-6","volume":"17","author":"W-f Sun","year":"2011","unstructured":"Sun W-f, Zhang X-x, Sun F-y, Xu W, Liang J, Feng S-m, Wang T (2011) MicroRNA expression patterns of the kidney in hyperuricemia mice treated with Xiezhuo Chubi Decoction (\u6cc4\u6d4a\u9664\u75f9\u65b9). Chin J Integr Med 17:35\u201342","journal-title":"Chin J Integr Med"},{"key":"3603_CR115","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.jep.2014.12.001","volume":"161","author":"W-F Sun","year":"2015","unstructured":"Sun W-F, Zhu M-M, Li J, Zhang X-X, Liu Y-W, Wu X-R, Liu Z-G (2015) Effects of Xie-Zhuo-Chu-Bi-Fang on miR-34a and URAT1 and their relationship in hyperuricemic mice. J Ethnopharmacol 161:163\u2013169","journal-title":"J Ethnopharmacol"},{"key":"3603_CR116","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/nyas.12458","volume":"1319","author":"FS Sutterwala","year":"2014","unstructured":"Sutterwala FS, Haasken S, Cassel SL (2014) Mechanism of NLRP3 inflammasome activation. Ann N Y Acad Sci 1319:82\u201395","journal-title":"Ann N Y Acad Sci"},{"key":"3603_CR117","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1111\/cas.12721","volume":"106","author":"HI Suzuki","year":"2015","unstructured":"Suzuki HI, Katsura A, Miyazono K (2015) A role of uridylation pathway for blockade of let-7 micro RNA biogenesis by Lin28B. Cancer Sci 106:1174\u20131181","journal-title":"Cancer Sci"},{"key":"3603_CR118","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.1093\/molbev\/msw116","volume":"33","author":"PK Tan","year":"2016","unstructured":"Tan PK, Farrar JE, Gaucher EA, Miner JN (2016) Coevolution of URAT1 and uricase during primate evolution: implications for serum urate homeostasis and gout. Mol Biol Evol 33:2193\u20132200","journal-title":"Mol Biol Evol"},{"key":"3603_CR119","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1111\/cei.13587","volume":"204","author":"J Tian","year":"2021","unstructured":"Tian J, Zhou D, Xiang L, Liu X, Zhang H, Wang B, Xie B (2021) MiR-223-3p inhibits inflammation and pyroptosis in monosodium urate-induced rats and fibroblast-like synoviocytes by targeting NLRP3. Clin Exp Immunol 204:396\u2013410","journal-title":"Clin Exp Immunol"},{"key":"3603_CR120","doi-asserted-by":"publisher","first-page":"4228","DOI":"10.1038\/s41467-018-06620-4","volume":"9","author":"A Tin","year":"2018","unstructured":"Tin A, Li Y, Brody JA, Nutile T, Chu AY, Huffman JE, Yang Q, Chen M-H, Robinson-Cohen C, Mac\u00e9 A (2018) Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels. Nat Commun 9:4228","journal-title":"Nat Commun"},{"key":"3603_CR121","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12891-019-2519-y","volume":"20","author":"P Towiwat","year":"2019","unstructured":"Towiwat P, Chhana A, Dalbeth N (2019) The anatomical pathology of gout: a systematic literature review. BMC Musculoskelet Disord 20:1\u201314","journal-title":"BMC Musculoskelet Disord"},{"key":"3603_CR122","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1111\/1756-185X.12622","volume":"18","author":"P Towiwat","year":"2015","unstructured":"Towiwat P, Li ZG (2015) The association of vitamin C, alcohol, coffee, tea, milk and yogurt with uric acid and gout. Int J Rheum Dis 18:495\u2013501","journal-title":"Int J Rheum Dis"},{"key":"3603_CR123","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.3390\/pharmaceutics13111832","volume":"13","author":"F Ursini","year":"2021","unstructured":"Ursini F, De Giorgi A, D\u2019Onghia M, De Giorgio R, Fabbian F, Manfredini R (2021) Chronobiology and chronotherapy in inflammatory joint diseases. Pharmaceutics 13:1832","journal-title":"Pharmaceutics"},{"key":"3603_CR124","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11926-016-0594-8","volume":"18","author":"AB Vargas-Santos","year":"2016","unstructured":"Vargas-Santos AB, Taylor WJ, Neogi T (2016) Gout classification criteria: update and implications. Curr Rheumatol Rep 18:1\u201310","journal-title":"Curr Rheumatol Rep"},{"key":"3603_CR125","first-page":"24","volume":"21","author":"W-W Wang","year":"2017","unstructured":"Wang W-W, Yang L, Wu J, Gao C, Zhu Y-X, Zhang D, Zhang H-X (2017) The function of miR-218 and miR-618 in postmenopausal osteoporosis. Eur Rev Med Pharmacol Sci 21:24","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"3603_CR126","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1111\/1756-185X.14089","volume":"24","author":"X Wang","year":"2021","unstructured":"Wang X, Chi J, Dong B, Xu L, Zhou Y, Huang Y, Sun S, Wei F, Liu Y, Liu C (2021) MiR-223-3p and miR-22-3p inhibit monosodium urate-induced gouty inflammation by targeting NLRP3. Int J Rheum Dis 24:599\u2013607","journal-title":"Int J Rheum Dis"},{"key":"3603_CR127","doi-asserted-by":"publisher","first-page":"e34641","DOI":"10.1371\/journal.pone.0034641","volume":"7","author":"Y Wang","year":"2012","unstructured":"Wang Y, Li L, Moore BT, Peng X-H, Fang X, Lappe JM, Recker RR, Xiao P (2012) MiR-133a in human circulating monocytes: a potential biomarker associated with postmenopausal osteoporosis. PLoS ONE 7:e34641","journal-title":"PLoS ONE"},{"key":"3603_CR128","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1038\/s41477-021-01000-1","volume":"7","author":"X Wei","year":"2021","unstructured":"Wei X, Ke H, Wen A, Gao B, Shi J, Feng Y (2021) Structural basis of microRNA processing by Dicer-like 1. Nat Plants 7:1389\u20131396","journal-title":"Nat Plants"},{"key":"3603_CR129","doi-asserted-by":"publisher","first-page":"BSR20170180","DOI":"10.1042\/BSR20170180","volume":"37","author":"C West","year":"2017","unstructured":"West C, McDermott MF (2017) Effects of microRNA-146a on the proliferation and apoptosis of human osteochondrocytes by targeting TRAF6 through the NF-\u03baB signalling pathway. Bioscience reports 37:BSR20170180","journal-title":"Bioscience reports"},{"key":"3603_CR130","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1373\/clinchem.2014.221341","volume":"61","author":"KW Witwer","year":"2015","unstructured":"Witwer KW (2015) Circulating microRNA biomarker studies: pitfalls and potential solutions. Clin Chem 61:56\u201363","journal-title":"Clin Chem"},{"key":"3603_CR131","doi-asserted-by":"publisher","first-page":"106842","DOI":"10.1016\/j.intimp.2020.106842","volume":"87","author":"Y-T Xu","year":"2020","unstructured":"Xu Y-T, Leng Y-R, Liu M-M, Dong R-F, Bian J, Yuan L-L, Zhang J-g, Xia Y-Z, Kong L-Y (2020) MicroRNA and long noncoding RNA involvement in gout and prospects for treatment. Int Immunopharmacol 87:106842","journal-title":"Int Immunopharmacol"},{"key":"3603_CR132","doi-asserted-by":"publisher","unstructured":"Yan D, Zhang Y (2020) Personalized medicine of urate-lowering therapy for gout. Recent Advances in Gout. 33. https:\/\/doi.org\/10.5772\/intechopen.85030","DOI":"10.5772\/intechopen.85030"},{"key":"3603_CR133","doi-asserted-by":"crossref","unstructured":"Yang Q-B, Li L-Q, Zhang Q-B, He Y-L, Mi Q-S, Zhou J-G (2021) MicroRNA-223 deficiency exacerbates acute inflammatory response to monosodium urate crystals by targeting NLRP3. J Inflamm Res 14: 1845\u20131858","DOI":"10.2147\/JIR.S307796"},{"key":"3603_CR134","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/s13075-018-1550-y","volume":"20","author":"Q Yang","year":"2018","unstructured":"Yang Q, Zhang Q, Qing Y, Zhou L, Mi Q, Zhou J (2018) miR-155 is dispensable in monosodium urate-induced gouty inflammation in mice. Arthritis Res Ther 20:144","journal-title":"Arthritis Res Ther"},{"key":"3603_CR135","doi-asserted-by":"publisher","first-page":"2487","DOI":"10.1253\/circj.CJ-15-0283","volume":"79","author":"S Yu","year":"2015","unstructured":"Yu S, Hong Q, Wang Y, Hou K, Wang L, Zhang Y, Fu B, Zhou Y, Zheng W, Chen X (2015) High concentrations of uric acid inhibit angiogenesis via regulation of the Kr\u00fcppel-like factor 2-vascular endothelial growth factor-A axis by miR-92a. Circ J 79:2487\u20132498","journal-title":"Circ J"},{"key":"3603_CR136","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.1007\/s10067-015-3109-5","volume":"35","author":"M Zeng","year":"2016","unstructured":"Zeng M, Dang W, Chen B, Qing Y, Xie W, Zhao M, Zhou J (2016) IL-37 inhibits the production of pro-inflammatory cytokines in MSU crystal-induced inflammatory response. Clin Rheumatol 35:2251\u20132258","journal-title":"Clin Rheumatol"},{"key":"3603_CR137","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1756-9966-33-10","volume":"33","author":"M Zhang","year":"2014","unstructured":"Zhang M, Yang Q, Zhang L, Zhou S, Ye W, Yao Q, Li Z, Huang C, Wen Q, Wang J (2014) miR-302b is a potential molecular marker of esophageal squamous cell carcinoma and functions as a tumor suppressor by targeting ErbB4. J Exp Clin Cancer Res 33:1\u201310","journal-title":"J Exp Clin Cancer Res"},{"key":"3603_CR138","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13075-018-1546-7","volume":"20","author":"Q-B Zhang","year":"2018","unstructured":"Zhang Q-B, Qing Y-F, Yin C-C, Zhou L, Liu X-s, Mi Q-S, Zhou J-G (2018) Mice with miR-146a deficiency develop severe gouty arthritis via dysregulation of TRAF 6, IRAK 1 and NALP3 inflammasome. Arthritis Res Ther 20:1\u20139","journal-title":"Arthritis Res Ther"},{"key":"3603_CR139","doi-asserted-by":"publisher","first-page":"637415","DOI":"10.3389\/fphar.2021.637415","volume":"12","author":"Q-B Zhang","year":"2021","unstructured":"Zhang Q-B, Zhu D, Dai F, Huang Y-Q, Zheng J-X, Tang Y-P, Dong Z-R, Liao X, Qing Y-F (2021) MicroRNA-223 suppresses IL-1\u03b2 and TNF-\u03b1 production in gouty inflammation by targeting the NLRP3 inflammasome. Front Pharmacol 12:637415","journal-title":"Front Pharmacol"},{"key":"3603_CR140","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1080\/15476286.2015.1017205","volume":"12","author":"C Zhao","year":"2015","unstructured":"Zhao C, Sun W, Zhang P, Ling S, Li Y, Zhao D, Peng J, Wang A, Li Q, Song J (2015) miR-214 promotes osteoclastogenesis by targeting Pten\/PI3k\/Akt pathway. RNA Biol 12:343\u2013353","journal-title":"RNA Biol"},{"key":"3603_CR141","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13075-017-1418-6","volume":"19","author":"W Zhou","year":"2017","unstructured":"Zhou W, Wang Y, Wu R, He Y, Su Q, Shi G (2017) MicroRNA-488 and-920 regulate the production of proinflammatory cytokines in acute gouty arthritis. Arthritis Res Ther 19:1\u201311","journal-title":"Arthritis Res Ther"},{"key":"3603_CR142","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.bbrc.2019.07.114","volume":"517","author":"Z Zhou","year":"2019","unstructured":"Zhou Z, Dong Y, Zhou H, Liu J, Zhao W (2019) MiR-143-3p directly targets GLUT9 to reduce uric acid reabsorption and inflammatory response of renal tubular epithelial cells. Biochem Biophys Res Commun 517:413\u2013420","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03603-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-024-03603-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03603-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T13:25:16Z","timestamp":1744205116000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-024-03603-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,19]]},"references-count":142,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["3603"],"URL":"https:\/\/doi.org\/10.1007\/s00210-024-03603-9","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,19]]},"assertion":[{"value":"18 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}