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This research aimed to assess the possible defenses against DOX-induced nephrotoxicity offered by oxyresveratrol (ORES) and\/or dapagliflozin (DAPA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Five groups of eight male Swiss albino rats each were created from a total of sixty-four. One intravenous injection of DOX (10\u00a0mg\/kg) was given into the tail vein on the fourteenth day of the experiment; in the meantime, ORES (80\u00a0mg\/kg) and DAPA (10\u00a0mg\/kg) were given orally 14 days prior to the DOX injection and 2 days following the DOX injection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In rats given DOX, ORES and\/or DAPA both successfully reduced the kidney weight, kidney\/bodyweight ratio, and blood levels of creatinine, uric acid, and urea. They also increased final body weight and albumin serum levels. Additionally, lower serum concentrations of TNF-\u03b1 and IL-6 were noted, along with a lower kidney content of caspase-3. Furthermore, the expression of the Bcl-2 gene was upregulated, as were the Nrf-2, PPAR-\u03b3, and HO-1 proteins, and there was a downregulation of the ATG-5, Keap-1, and NF-\u03baB renal gene expression. These findings support a decrease in oxidative stress and relief of histopathological alterations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The current study\u2019s findings suggest that ORES and\/or DAPA pretreatment could be a viable therapeutic approach to ameliorate DOX-induced nephrotoxicity.\u00a0<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00210-024-03608-4","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T02:55:34Z","timestamp":1733194534000},"page":"5955-5967","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Oxyresveratrol and\/or Dapagliflozin Attenuate Doxorubicin-Induced Nephrotoxicity via Modulation of PPAR-\u03b3\/Nrf-2\/HO-1, NF-\u03baB\/TNF-\u03b1\/Keap-1, and Bcl-2\/Caspase-3\/ATG-5 signaling pathways in rats"],"prefix":"10.1007","volume":"398","author":[{"given":"Waleed S M","family":"El-Sawy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa M","family":"Khalaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali H","family":"El-Bahrawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basim A S","family":"Messiha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramadan A M","family":"Hemeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"key":"3608_CR1","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.biopha.2018.03.176","volume":"103","author":"AF Abdel-Wahab","year":"2018","unstructured":"Abdel-Wahab AF, Bamagous GA, Al-Harizy RM, ElSawy NA, Shahzad N, Ibrahim IA, Al Ghamdi SS (2018) Renal protective effect of SGLT2 inhibitor dapagliflozin alone and in combination with irbesartan in a rat model of diabetic nephropathy. 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