{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:47:09Z","timestamp":1783950429261,"version":"3.55.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Erciyes University Scientific Research Projects (BAP) unit","award":["TDK-2020-10342"],"award-info":[{"award-number":["TDK-2020-10342"]}]},{"name":"Erciyes University Scientific Research Projects (BAP) unit","award":["TDK-2020-10342"],"award-info":[{"award-number":["TDK-2020-10342"]}]},{"name":"Erciyes University Scientific Research Projects (BAP) unit","award":["TDK-2020-10342"],"award-info":[{"award-number":["TDK-2020-10342"]}]},{"name":"Erciyes University Scientific Research Projects (BAP) unit","award":["TDK-2020-10342"],"award-info":[{"award-number":["TDK-2020-10342"]}]},{"name":"Erciyes University Scientific Research Projects (BAP) unit","award":["TDK-2020-10342"],"award-info":[{"award-number":["TDK-2020-10342"]}]},{"name":"Erciyes University Scientific Research Projects (BAP) unit","award":["TDK-2020-10342"],"award-info":[{"award-number":["TDK-2020-10342"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1007\/s00210-024-03633-3","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T07:50:16Z","timestamp":1733212216000},"page":"5969-5988","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Protective effect of deinoxanthin in sorafenib-induced nephrotoxicity in rats with the hepatocellular carcinoma model"],"prefix":"10.1007","volume":"398","author":[{"given":"Nilgun","family":"Karasu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Kuzucu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozge Cengiz","family":"Mat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Gul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arzu","family":"Yay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0969-4611","authenticated-orcid":false,"given":"Munis","family":"Dundar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"key":"3633_CR1","doi-asserted-by":"publisher","unstructured":"Abdalla Y, Abdalla A, Hamza AA, Amin A (2022) Safranal prevents liver cancer through inhibiting oxidative stress and alleviating inflammation. Front Pharmacol 12. https:\/\/doi.org\/10.3389\/fphar.2021.777500","DOI":"10.3389\/fphar.2021.777500"},{"key":"3633_CR2","doi-asserted-by":"publisher","unstructured":"Abdu S, Juaid N, Amin A et al (2022a) Therapeutic effects of crocin alone or in combination with sorafenib against hepatocellular carcinoma: in vivo & in vitro insights. Antioxidants 11. https:\/\/doi.org\/10.3390\/antiox11091645","DOI":"10.3390\/antiox11091645"},{"key":"3633_CR3","doi-asserted-by":"publisher","unstructured":"Abdu S, Juaid N, Amin A et al (2022b) Effects of sorafenib and quercetin alone or in combination in treating hepatocellular carcinoma: in vitro and in vivo approaches. Molecules 27. https:\/\/doi.org\/10.3390\/molecules27228082","DOI":"10.3390\/molecules27228082"},{"key":"3633_CR4","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","volume":"105","author":"H Aebi","year":"1984","unstructured":"Aebi H (1984) [13] Catalase in Vitro. Methods Enzymol 105:121\u2013126. https:\/\/doi.org\/10.1016\/S0076-6879(84)05016-3","journal-title":"Methods Enzymol"},{"issue":"4","key":"3633_CR5","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1023\/B:BIOP.0000047152.07878.e7","volume":"48","author":"S Agarwal","year":"2004","unstructured":"Agarwal S, Pandey V (2004) Antioxidant enzyme responses to NaCl stress in Cassia angustifolia. Biol Plant 48(4):555\u2013560","journal-title":"Biol Plant"},{"key":"3633_CR6","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.etp.2009.12.002","volume":"63","author":"Y An","year":"2011","unstructured":"An Y, Xin H, Yan W, Zhou X (2011) Amelioration of cisplatin-induced nephrotoxicity by pravastatin in mice. Exp Toxicol Pathol 63:215\u2013219. https:\/\/doi.org\/10.1016\/j.etp.2009.12.002","journal-title":"Exp Toxicol Pathol"},{"key":"3633_CR7","doi-asserted-by":"publisher","unstructured":"Awad B, Hamza AA, Al-Maktoum A et al (2023) Combining crocin and sorafenib improves their tumor-inhibiting effects in a rat model of diethylnitrosamine-induced cirrhotic-hepatocellular carcinoma. Cancers (Basel) 15. https:\/\/doi.org\/10.3390\/cancers15164063","DOI":"10.3390\/cancers15164063"},{"key":"3633_CR8","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.3892\/ijmm.2018.3725","volume":"42","author":"AA Bahman","year":"2018","unstructured":"Bahman AA, Abaza MSI, Khoushiash SI, Al-Attiyah RJ (2018) Sequence-dependent effect of sorafenib in combination with natural phenolic compounds on hepatic cancer cells and the possible mechanism of action. Int J Mol Med 42:1695\u20131715. https:\/\/doi.org\/10.3892\/ijmm.2018.3725","journal-title":"Int J Mol Med"},{"key":"3633_CR9","doi-asserted-by":"publisher","unstructured":"Baldan Ferrari G, Quintanilha JCF, Berlofa Visacri M et al (2020) Outcomes in hepatocellular carcinoma patients undergoing sorafenib treatment: toxicities, cellular oxidative stress, treatment adherence, and quality of life. Anticancer Drugs 523\u2013527. https:\/\/doi.org\/10.1097\/CAD.0000000000000902","DOI":"10.1097\/CAD.0000000000000902"},{"key":"3633_CR10","first-page":"882","volume":"61","author":"E Beutler","year":"1963","unstructured":"Beutler E, Duron O, Kelly BM (1963) Improved method for the determination of blood glutathione. J Lab Clin Med 61:882\u2013888","journal-title":"J Lab Clin Med"},{"key":"3633_CR11","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1517\/14740330903510608","volume":"9","author":"B Blanchet","year":"2010","unstructured":"Blanchet B, Billemont B, Barete S et al (2010) Toxicity of sorafenib: clinical and molecular aspects. Expert Opin Drug Saf 9:275\u2013287","journal-title":"Expert Opin Drug Saf"},{"key":"3633_CR12","doi-asserted-by":"publisher","unstructured":"Botros SR, Matouk AI, Amin A, Heeba GH (2024) Comparative effects of incretin-based therapy on doxorubicin-induced nephrotoxicity in rats: the role of SIRT1\/Nrf2\/NF-\u03baB\/TNF-\u03b1 signaling pathways. Front Pharmacol 15. https:\/\/doi.org\/10.3389\/fphar.2024.1353029","DOI":"10.3389\/fphar.2024.1353029"},{"issue":"15","key":"3633_CR13","doi-asserted-by":"publisher","first-page":"3900","DOI":"10.3390\/cancers15153900","volume":"15","author":"S Bouabdallah","year":"2023","unstructured":"Bouabdallah S, Al-Maktoum A, Amin A (2023) Steroidal saponins: naturally occurring compounds as inhibitors of the hallmarks of cancer. Cancers (Basel) 15(15):3900","journal-title":"Cancers (Basel)"},{"key":"3633_CR14","doi-asserted-by":"publisher","first-page":"20968","DOI":"10.1007\/s11356-018-2242-5","volume":"25","author":"C Caglayan","year":"2018","unstructured":"Caglayan C, Temel Y, Kandemir FM et al (2018) Naringin protects against cyclophosphamide-induced hepatotoxicity and nephrotoxicity through modulation of oxidative stress, inflammation, apoptosis, autophagy, and DNA damage. Environ Sci Pollut Res 25:20968\u201320984. https:\/\/doi.org\/10.1007\/s11356-018-2242-5","journal-title":"Environ Sci Pollut Res"},{"key":"3633_CR15","doi-asserted-by":"publisher","first-page":"108","DOI":"10.14715\/cmb\/2018.64.14.18","volume":"64","author":"OY Celik","year":"2018","unstructured":"Celik OY, Irak K (2018) Protective effect of date extract on rat nephrotoxicity induced by gentamicin, clinical, histological and antioxidant evidences. Cell Mol Biol 64:108\u2013113. https:\/\/doi.org\/10.14715\/cmb\/2018.64.14.18","journal-title":"Cell Mol Biol"},{"key":"3633_CR16","doi-asserted-by":"crossref","unstructured":"Chen C, Xie D, Gewirtz DA, Li N (2022) Nephrotoxicity in cancer treatment: an update. In: Advances in cancer research, vol 155. Academic Press Inc., pp 77\u2013129","DOI":"10.1016\/bs.acr.2022.03.005"},{"key":"3633_CR17","doi-asserted-by":"publisher","unstructured":"Cheng F, Kov\u00e1cs IA, Barab\u00e1si AL (2019) Network-based prediction of drug combinations. Nat Commun 10:. https:\/\/doi.org\/10.1038\/s41467-019-09186-x","DOI":"10.1038\/s41467-019-09186-x"},{"issue":"4","key":"3633_CR18","first-page":"1829","volume":"34","author":"YJ Choi","year":"2014","unstructured":"Choi YJ, Hur JM, Lim S, Jo M, Kim DH, Choi JI (2014) Induction of apoptosis by deinoxanthin in human cancer cells. Anticancer Res 34(4):1829\u20131835","journal-title":"Anticancer Res"},{"key":"3633_CR19","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s40620-016-0311-8","volume":"30","author":"L Cosmai","year":"2017","unstructured":"Cosmai L, Gallieni M, Liguigli W, Porta C (2017) Renal toxicity of anticancer agents targeting vascular endothelial growth factor (VEGF) and its receptors (VEGFRs). J Nephrol 30:171\u2013180","journal-title":"J Nephrol"},{"issue":"11","key":"3633_CR20","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1056\/NEJMoa0707330","volume":"358","author":"V Eremina","year":"2008","unstructured":"Eremina V, Jefferson JA, Kowalewska J et al (2008) VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med 358(11):1129\u20131136","journal-title":"N Engl J Med"},{"key":"3633_CR21","doi-asserted-by":"publisher","unstructured":"Gergin \u00d6\u00d6, Pehlivan SS, Ulger M et al (2022) Efficacy of stem cell-based therapies for colistin-induced nephrotoxicity. Environ Toxicol Pharmacol 94. https:\/\/doi.org\/10.1016\/j.etap.2022.103933","DOI":"10.1016\/j.etap.2022.103933"},{"key":"3633_CR22","doi-asserted-by":"publisher","unstructured":"Gur C, Kandemir FM, Caglayan C, Sat\u0131c\u0131 E (2022) Chemopreventive effects of hesperidin against paclitaxel-induced hepatotoxicity and nephrotoxicity via amendment of Nrf2\/HO-1 and caspase-3\/Bax\/Bcl-2 signaling pathways. Chem Biol Interact 365. https:\/\/doi.org\/10.1016\/j.cbi.2022.110073","DOI":"10.1016\/j.cbi.2022.110073"},{"key":"3633_CR23","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.abb.2008.01.028","volume":"476","author":"B Halliwell","year":"2008","unstructured":"Halliwell B (2008) Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies? Arch Biochem Biophys 476:107\u2013112","journal-title":"Arch Biochem Biophys"},{"key":"3633_CR24","doi-asserted-by":"publisher","unstructured":"Hassanin SO, Hegab AMM, Mekky RH et al (2024) Combining in vitro, in vivo, and network pharmacology assays to identify targets and molecular mechanisms of spirulina-derived biomolecules against breast cancer. Mar Drugs 22. https:\/\/doi.org\/10.3390\/md22070328","DOI":"10.3390\/md22070328"},{"key":"3633_CR25","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1093\/jjco\/hyx180","volume":"48","author":"M Ikeda","year":"2018","unstructured":"Ikeda M, Morizane C, Ueno M et al (2018) Chemotherapy for hepatocellular carcinoma: Current status and future perspectives. Jpn J Clin Oncol 48:103\u2013114. https:\/\/doi.org\/10.1093\/jjco\/hyx180","journal-title":"Jpn J Clin Oncol"},{"key":"3633_CR26","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1007\/s00204-012-0849-8","volume":"86","author":"IC Lee","year":"2012","unstructured":"Lee IC, Kim SH, Lee SM et al (2012) Melatonin attenuates gentamicin-induced nephrotoxicity and oxidative stress in rats. Arch Toxicol 86:1527\u20131536. https:\/\/doi.org\/10.1007\/s00204-012-0849-8","journal-title":"Arch Toxicol"},{"key":"3633_CR27","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.fct.2017.10.006","volume":"110","author":"ZN Ma","year":"2017","unstructured":"Ma ZN, Liu Z, Wang Z et al (2017) Supplementation of American ginseng berry extract mitigated cisplatin-evoked nephrotoxicity by suppressing ROS-mediated activation of MAPK and NF-\u03baB signaling pathways. Food Chem Toxicol 110:62\u201373. https:\/\/doi.org\/10.1016\/j.fct.2017.10.006","journal-title":"Food Chem Toxicol"},{"key":"3633_CR28","doi-asserted-by":"publisher","unstructured":"Mi X jie, Hou J gang, Wang Z, et al (2018) The protective effects of maltol on cisplatin-induced nephrotoxicity through the AMPK-mediated PI3K\/Akt and p53 signaling pathways. Sci Rep 8. https:\/\/doi.org\/10.1038\/s41598-018-34156-6","DOI":"10.1038\/s41598-018-34156-6"},{"key":"3633_CR29","doi-asserted-by":"publisher","unstructured":"Murali C, Mudgil P, Gan CY et al (2021) Camel whey protein hydrolysates induced G2\/M cellcycle arrest in human colorectal carcinoma. Sci Rep 11. https:\/\/doi.org\/10.1038\/s41598-021-86391-z","DOI":"10.1038\/s41598-021-86391-z"},{"key":"3633_CR30","doi-asserted-by":"publisher","unstructured":"Nelson DR, Al Hrout A, Alzahmi AS et al (2022) Molecular Mechanisms behind Safranal\u2019s toxicity to HepG2 Cells from Dual Omics. Antioxidants 11. https:\/\/doi.org\/10.3390\/antiox11061125","DOI":"10.3390\/antiox11061125"},{"key":"3633_CR31","doi-asserted-by":"publisher","first-page":"S324","DOI":"10.4103\/0973-1482.235349","volume":"14","author":"LH Odeh","year":"2018","unstructured":"Odeh LH, Talib WH, Basheti IA (2018) Synergistic effect of thymoquinone and melatonin against breast cancer implanted in mice. J Cancer Res Ther 14:S324\u2013S330. https:\/\/doi.org\/10.4103\/0973-1482.235349","journal-title":"J Cancer Res Ther"},{"key":"3633_CR32","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1007\/s11011-022-00952-3","volume":"37","author":"U Okkay","year":"2022","unstructured":"Okkay U, FerahOkkay I, Cicek B et al (2022) Hepatoprotective and neuroprotective effect of taxifolin on hepatic encephalopathy in rats. Metab Brain Dis 37:1541\u20131556. https:\/\/doi.org\/10.1007\/s11011-022-00952-3","journal-title":"Metab Brain Dis"},{"key":"3633_CR33","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1093\/annonc\/mdp472","volume":"21","author":"ENM Overkleeft","year":"2009","unstructured":"Overkleeft ENM, Goldschmeding R, van Reekum F et al (2009) Nephrotic syndrome caused by the angiogenesis inhibitor sorafenib. Ann Oncol 21:184\u2013185","journal-title":"Ann Oncol"},{"key":"3633_CR34","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1681\/ASN.2010080871","volume":"21","author":"SM Parikh","year":"2010","unstructured":"Parikh SM, Pollak MR (2010) VEGF receptors and glomerular function. J Am Soc Nephrol 21:1599\u20131600","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"3633_CR35","first-page":"51","volume":"27","author":"H Parlakpinar","year":"2013","unstructured":"Parlakpinar H, \u00d6r\u00fcm MH, Acet A (2013) \u0130laca ba\u011fl\u0131 nefrotoksisitede serbest oksijen radikalleri. F\u0131rat \u00dcniversitesi Sa\u011fl\u0131k Bilimleri T\u0131p Dergisi 27(1):51\u201356","journal-title":"F\u0131rat \u00dcniversitesi Sa\u011fl\u0131k Bilimleri T\u0131p Dergisi"},{"key":"3633_CR36","doi-asserted-by":"publisher","first-page":"107845","DOI":"10.1016\/j.intimp.2021.107845","volume":"98","author":"S Radbakhsh","year":"2021","unstructured":"Radbakhsh S, Atkin SL, Simental-Mendia LE, Sahebkar A (2021) The role of incretins and incretin-based drugs in autoimmune diseases. Int Immunopharmacol 98:107845","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"3633_CR37","first-page":"761264","volume":"2014","author":"A Rahal","year":"2014","unstructured":"Rahal A, Kumar A, Singh V, Yadav B, Tiwari R, Chakraborty S, Dhama K (2014a) Oxidative stress, prooxidants, and antioxidants: the interplay. Biomed Res Int 2014(1):761264","journal-title":"Biomed Res Int"},{"key":"3633_CR38","doi-asserted-by":"publisher","unstructured":"Rahal A, Kumar A, Singh V et al (2014b) Oxidative stress, prooxidants, and antioxidants: the interplay. Biomed Res Int 2014. https:\/\/doi.org\/10.1155\/2014\/761264","DOI":"10.1155\/2014\/761264"},{"key":"3633_CR39","first-page":"S70","volume":"27","author":"C Rollino","year":"2010","unstructured":"Rollino C, Beltrame G, Ferro M, Quattrocchio G, Tonda L, Quarello F (2010) Cancer treatment-induced nephrotoxicity: BCR-Abl and VEGF inhibitors. Giornale italiano di nefrologia: organo ufficiale della Societa italiana di nefrologia 27:S70-4","journal-title":"Giornale italiano di nefrologia: organo ufficiale della Societa italiana di nefrologia"},{"key":"3633_CR40","doi-asserted-by":"publisher","first-page":"295","DOI":"10.23876\/j.krcp.19.042","volume":"38","author":"MH Rosner","year":"2019","unstructured":"Rosner MH, Perazella MA (2019) Acute kidney injury in the patient with cancer. Kidney Res Clin Pract 38:295\u2013308","journal-title":"Kidney Res Clin Pract"},{"key":"3633_CR41","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1681\/ASN.2010030295","volume":"21","author":"K Sison","year":"2010","unstructured":"Sison K, Eremina V, Baelde H et al (2010) Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signaling. J Am Soc Nephrol 21:1691\u20131701. https:\/\/doi.org\/10.1681\/ASN.2010030295","journal-title":"J Am Soc Nephrol"},{"key":"3633_CR42","doi-asserted-by":"publisher","first-page":"25","DOI":"10.17721\/1728_2748.2020.81.25-31","volume":"81","author":"A Stavniichuk","year":"2020","unstructured":"Stavniichuk A, Savchuk O, Khan AH et al (2020) A sorafenib-induced model of glomerular kidney disease. Bull Taras Shevchenko Natl Univ Kyiv Ser: Biol 81:25\u201331. https:\/\/doi.org\/10.17721\/1728_2748.2020.81.25-31","journal-title":"Bull Taras Shevchenko Natl Univ Kyiv Ser: Biol"},{"key":"3633_CR43","doi-asserted-by":"publisher","first-page":"171","DOI":"10.3109\/0886022X.2015.1120097","volume":"38","author":"F Tamay-Cach","year":"2016","unstructured":"Tamay-Cach F, Quintana-P\u00e9rez JC, Trujillo-Ferrara JG et al (2016) A review of the impact of oxidative stress and some antioxidant therapies on renal damage. Ren Fail 38:171\u2013175","journal-title":"Ren Fail"},{"key":"3633_CR44","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s41581-022-00631-7","volume":"19","author":"C Tang","year":"2023","unstructured":"Tang C, Livingston MJ, Safirstein R, Dong Z (2023) Cisplatin nephrotoxicity: new insights and therapeutic implications. Nat Rev Nephrol 19:53\u201372","journal-title":"Nat Rev Nephrol"},{"key":"3633_CR45","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s00210-019-01741-z","volume":"393","author":"Y Temel","year":"2020","unstructured":"Temel Y, Kucukler S, Y\u0131ld\u0131r\u0131m S et al (2020) Protective effect of chrysin on cyclophosphamide-induced hepatotoxicity and nephrotoxicity via the inhibition of oxidative stress, inflammation, and apoptosis. Naunyn Schmiedebergs Arch Pharmacol 393:325\u2013337. https:\/\/doi.org\/10.1007\/s00210-019-01741-z","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"3633_CR46","doi-asserted-by":"publisher","first-page":"183","DOI":"10.23876\/j.krcp.20.163","volume":"40","author":"S Verma","year":"2021","unstructured":"Verma S, Singh P, Khurana S et al (2021) Implications of oxidative stress in chronic kidney disease: a review on current concepts and therapies. Kidney Res Clin Pract 40:183\u2013193","journal-title":"Kidney Res Clin Pract"},{"key":"3633_CR47","doi-asserted-by":"publisher","unstructured":"Walko CM, Grande C (2014) Management of common adverse events in patients treated with Sorafenib: nurse and pharmacist perspective. Semin Oncol 41. https:\/\/doi.org\/10.1053\/j.seminoncol.2014.01.002","DOI":"10.1053\/j.seminoncol.2014.01.002"},{"key":"3633_CR48","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.fct.2018.02.041","volume":"114","author":"SW Wang","year":"2018","unstructured":"Wang SW, Xu Y, Weng YY et al (2018) Astilbin ameliorates cisplatin-induced nephrotoxicity through reducing oxidative stress and inflammation. Food Chem Toxicol 114:227\u2013236. https:\/\/doi.org\/10.1016\/j.fct.2018.02.041","journal-title":"Food Chem Toxicol"},{"key":"3633_CR49","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.bcp.2011.09.029","volume":"83","author":"CC Woo","year":"2012","unstructured":"Woo CC, Kumar AP, Sethi G, Tan KHB (2012) Thymoquinone: potential cure for inflammatory disorders and cancer. Biochem Pharmacol 83:443\u2013451","journal-title":"Biochem Pharmacol"},{"key":"3633_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ymthe.2019.04.020","volume":"27","author":"X Wu","year":"2019","unstructured":"Wu X, Luo H, Shi B et al (2019) Combined antitumor effects of sorafenib and GPC3-CAR T cells in mouse models of hepatocellular carcinoma. Mol Ther 27:1\u201312. https:\/\/doi.org\/10.1016\/j.ymthe.2019.04.020","journal-title":"Mol Ther"},{"issue":"1","key":"3633_CR51","doi-asserted-by":"publisher","first-page":"9959320","DOI":"10.1155\/2021\/9959320","volume":"2021","author":"H Yaribeygi","year":"2021","unstructured":"Yaribeygi H, Maleki M, Sathyapalan T et al (2021) (2021) Antioxidative potentials of incretin-based medications: a review of molecular mechanisms. Oxid Med Cell Longev 2021(1):9959320","journal-title":"Oxid Med Cell Longev"},{"key":"3633_CR52","doi-asserted-by":"publisher","first-page":"4104","DOI":"10.3748\/wjg.v27.i26.4104","volume":"27","author":"H Yeh","year":"2021","unstructured":"Yeh H, Chiang CC, Yen TH (2021) Hepatocellular carcinoma in patients with renal dysfunction: pathophysiology, prognosis, and treatment challenges. World J Gastroenterol 27:4104\u20134142","journal-title":"World J Gastroenterol"},{"issue":"11","key":"3633_CR53","doi-asserted-by":"publisher","first-page":"2925","DOI":"10.1007\/s00210-023-02559-6","volume":"396","author":"D Zhang","year":"2023","unstructured":"Zhang D, Luo G, Jin K, Bao X, Huang L, Ke J (2023) The underlying mechanisms of cisplatin-induced nephrotoxicity and its therapeutic intervention using natural compounds. Naunyn Schmiedeberg\u2019s Arch Pharmacol 396(11):2925\u20132941","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"3633_CR54","doi-asserted-by":"publisher","first-page":"10539","DOI":"10.1007\/s00253-015-6910-9","volume":"99","author":"Z Zhou","year":"2015","unstructured":"Zhou Z, Zhang W, Su S et al (2015) CYP287A1 is a carotenoid 2-\u03b2-hydroxylase required for deinoxanthin biosynthesis in Deinococcus radiodurans R1. Appl Microbiol Biotechnol 99:10539\u201310546. https:\/\/doi.org\/10.1007\/s00253-015-6910-9","journal-title":"Appl Microbiol Biotechnol"},{"key":"3633_CR55","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.7150\/ijbs.32550","volume":"15","author":"B Zhou","year":"2019","unstructured":"Zhou B, Lu Q, Liu J et al (2019) Melatonin increases the sensitivity of hepatocellular carcinoma to sorafenib through the PERK-ATf4-Beclin1 pathway. Int J Biol Sci 15:1905\u20131920. https:\/\/doi.org\/10.7150\/ijbs.32550","journal-title":"Int J Biol Sci"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03633-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-024-03633-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03633-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T08:18:38Z","timestamp":1744273118000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-024-03633-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,3]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["3633"],"URL":"https:\/\/doi.org\/10.1007\/s00210-024-03633-3","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,3]]},"assertion":[{"value":"9 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Erciyes University Local Ethics Committee for Animal Experiments with a decision dated Jun. 11th, 2019, and numbered 19\/197.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}