{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T17:35:18Z","timestamp":1776447318490,"version":"3.51.2"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1007\/s00210-024-03665-9","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T14:02:22Z","timestamp":1732802542000},"page":"5757-5771","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Unveiling the anxiolytic and analgesic effects of citronellal in Swiss mice: in vivo and in silico insights into COX and GABAA receptor pathways"],"prefix":"10.1007","volume":"398","author":[{"given":"Muhammad Torequl","family":"Islam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Sakib","family":"Al Hasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raihan","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emon","family":"Mia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imam Hossen","family":"Rakib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noshin Tasnim","family":"Yana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heba A. S.","family":"El-Nashar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddique Akber","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irfan Aamer","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Amirul","family":"Islam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zainab M.","family":"Almarhoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William N.","family":"Setzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javad","family":"Sharifi-Rad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"issue":"4","key":"3665_CR1","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.jtcme.2019.01.003","volume":"10","author":"S Abbasi-Maleki","year":"2020","unstructured":"Abbasi-Maleki S, Kadkhoda Z, Taghizad-Farid R (2020) The antidepressant-like effects of Origanum majorana essential oil on mice through monoaminergic modulation using the forced swimming test. J Tradit Complement Med 10(4):327\u2013335","journal-title":"J Tradit Complement Med"},{"issue":"1","key":"3665_CR2","doi-asserted-by":"publisher","first-page":"13398","DOI":"10.1038\/s41598-023-40160-2","volume":"13","author":"PC Agu","year":"2023","unstructured":"Agu PC, Afiukwa CA, Orji OU, Ezeh EM, Ofoke IH, Ogbu CO, Ugwuja EI, Aja PM (2023) Molecular docking as a tool for the discovery of molecular targets of nutraceuticals in diseases management. Sci Rep 13(1):13398. https:\/\/doi.org\/10.1038\/s41598-023-40160-2","journal-title":"Sci Rep"},{"issue":"4","key":"3665_CR3","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1007\/s13668-022-00441-0","volume":"11","author":"\u015e Akp\u0131nar","year":"2022","unstructured":"Akp\u0131nar \u015e, Karada\u011f MG (2022) Is vitamin D important in anxiety or depression? What is the truth? Curr Nutr Rep 11(4):675\u2013681. https:\/\/doi.org\/10.1007\/s13668-022-00441-0","journal-title":"Curr Nutr Rep"},{"key":"3665_CR4","doi-asserted-by":"crossref","unstructured":"Akter A, Islam F, Bepary S, Al-Amin M, Begh MZA, Islam MAFU, ... Ullah MF (2022) CNS depressant activities of Averrhoa carambola leaves extract in thiopental-sodium model of Swiss albino mice: implication for neuro-modulatory properties. Biologia 77(5):1337\u20131346","DOI":"10.1007\/s11756-022-01057-z"},{"key":"3665_CR5","first-page":"49","volume":"12","author":"EL Andrade","year":"2016","unstructured":"Andrade EL, Bento AF, Cavalli J, Oliveira SK, Schwanke RC, Siqueira JM, Freitas CS, Marcon R, Calixto JB (2016) Non-clinical studies in the process of new drug development-Part II: Good laboratory practice, metabolism, pharmacokinetics, safety and dose translation to clinical studies. Braz J Med Biol Res 12:49","journal-title":"Braz J Med Biol Res"},{"issue":"9","key":"3665_CR6","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.3390\/ph16091271","volume":"16","author":"MS Bhuia","year":"2023","unstructured":"Bhuia MS, Rokonuzzman M, Hossain MI, Ansari SA, Ansari IA, Islam T, Al Hasan MS, Mubarak MS, Islam MT (2023) Anxiolytic-like effects by trans-ferulic acid possibly occur through GABAergic interaction pathways. Pharmaceuticals (Basel, Switzerland) 16(9):1271. https:\/\/doi.org\/10.3390\/ph16091271","journal-title":"Pharmaceuticals (Basel, Switzerland)"},{"key":"3665_CR7","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1745-6150-7-12","volume":"7","author":"GM Boratyn","year":"2012","unstructured":"Boratyn GM, Sch\u00e4ffer AA, Agarwala R, Altschul SF, Lipman DJ, Madden TL (2012) Domain enhanced lookup time accelerated BLAST. Biol Direct 7:12. https:\/\/doi.org\/10.1186\/1745-6150-7-12","journal-title":"Biol Direct"},{"key":"3665_CR8","doi-asserted-by":"crossref","unstructured":"Bordes J, Miranda L, Reinhardt M, Narayan S, Hartmann J, Newman EL, ... Schmidt MV (2023) Automatically annotated motion tracking identifies a distinct social behavioral profile following chronic social defeat stress. Nat Commun 14(1):4319","DOI":"10.1038\/s41467-023-40040-3"},{"key":"3665_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nprot.2008.197","volume":"4","author":"L Bordoli","year":"2009","unstructured":"Bordoli L, Kiefer F, Arnold K, Benkert P, Battey J, Schwede T (2009) Protein structure homology modeling using SWISS-MODEL workspace. Nat Protoc 4:1\u201313. https:\/\/doi.org\/10.1038\/nprot.2008.197","journal-title":"Nat Protoc"},{"issue":"3","key":"3665_CR10","doi-asserted-by":"publisher","first-page":"295","DOI":"10.31887\/DCNS.2015.17.3\/mbourin","volume":"17","author":"M Bourin","year":"2015","unstructured":"Bourin M (2015) Animal models for screening anxiolytic-like drugs: a perspective. Dialogues Clin Neurosci 17(3):295\u2013303. https:\/\/doi.org\/10.31887\/DCNS.2015.17.3\/mbourin","journal-title":"Dialogues Clin Neurosci"},{"key":"3665_CR11","doi-asserted-by":"publisher","first-page":"108520","DOI":"10.1016\/j.apacoust.2021.108520","volume":"187","author":"S Bousshine","year":"2022","unstructured":"Bousshine S, Ouakarrouch M, Bybi A, Laaroussi N, Garoum M, Tilioua A (2022) Acoustical and thermal characterization of sustainable materials derived from vegetable, agricultural, and animal fibers. Appl Acoust 187:108520","journal-title":"Appl Acoust"},{"issue":"6","key":"3665_CR12","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1007\/s00038-011-0296-y","volume":"56","author":"M Braubach","year":"2011","unstructured":"Braubach M (2011) Key challenges of housing and health from WHO perspective. Int J Public Health 56(6):579\u2013580","journal-title":"Int J Public Health"},{"key":"3665_CR13","unstructured":"Brodal P (2010) The central nervous system: structure and function. Oxford Univ Pr"},{"issue":"12","key":"3665_CR14","doi-asserted-by":"publisher","first-page":"e13967","DOI":"10.1111\/jfbc.13967","volume":"45","author":"MS Butt","year":"2021","unstructured":"Butt MS, Tariq U, Iahtisham-Ul-Haq, Naz A, Rizwan M (2021) Neuroprotective effects of oleuropein: Recent developments and contemporary research. J Food Biochem 45(12):e13967. https:\/\/doi.org\/10.1111\/jfbc.13967","journal-title":"J Food Biochem"},{"key":"3665_CR15","doi-asserted-by":"crossref","unstructured":"Chowdhury R, Bhuia MS, Al Hasan MS, Ansari SA, Ansari IA, Gurgel APAD, ... Islam MT (2024) Anticonvulsant effect of (\u00b1) citronellal possibly through the GABAergic and voltage-gated sodium channel receptor interaction pathways: In vivo and in silico studies. Neurochem Int 175:105704","DOI":"10.1016\/j.neuint.2024.105704"},{"issue":"1","key":"3665_CR16","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1016\/j.jep.2011.07.003","volume":"137","author":"CA Costa","year":"2011","unstructured":"Costa CA, Kohn DO, de Lima VM, Gargano AC, Fl\u00f3rio JC, Costa M (2011) The GABAergic system contributes to the anxiolytic-like effect of essential oil from Cymbopogon citratus (lemongrass). J Ethnopharmacol 137(1):828\u2013836. https:\/\/doi.org\/10.1016\/j.jep.2011.07.003","journal-title":"J Ethnopharmacol"},{"key":"3665_CR17","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.brainres.2013.12.003","volume":"1547","author":"JP Costa","year":"2014","unstructured":"Costa JP, Oliveira GAL, Almeida AAC, Islam MT, Sousa DP, Freitas RM (2014) Anxiolytic-like effects of phytol: possible involvement of GABAergic transmission. Brain Res 1547:34\u201342. https:\/\/doi.org\/10.1016\/j.brainres.2013.12.003","journal-title":"Brain Res"},{"key":"3665_CR18","doi-asserted-by":"publisher","first-page":"136803","DOI":"10.1016\/j.neulet.2022.136803","volume":"786","author":"A El Aissouq","year":"2022","unstructured":"El Aissouq A, Bouachrine M, Ouammou A, Khalil F (2022) Homology modeling, virtual screening, molecular docking, molecular dynamic (MD) simulation, and ADMET approaches for identification of natural anti-Parkinson agents targeting MAO-B protein. Neurosci Lett 786:136803","journal-title":"Neurosci Lett"},{"key":"3665_CR19","doi-asserted-by":"crossref","unstructured":"El-Saadony MT, Zabermawi NM, Zabermawi NM, Burollus MA, Shafi ME, Alagawany M, ... Abd El-Hack ME (2023) Nutritional aspects and health benefits of bioactive plant compounds against infectious diseases: a review. Food Rev Int 39(4):2138\u20132160","DOI":"10.1080\/87559129.2021.1944183"},{"key":"3665_CR20","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/7854_2020_171","volume":"52","author":"D Felice","year":"2022","unstructured":"Felice D, Cryan JF, O\u2019Leary OF (2022) GABAB receptors: anxiety and mood disorders. Curr Top Behav Neurosci 52:241\u2013265. https:\/\/doi.org\/10.1007\/7854_2020_171","journal-title":"Curr Top Behav Neurosci"},{"issue":"15","key":"3665_CR21","doi-asserted-by":"publisher","first-page":"2004182","DOI":"10.1002\/smll.202004182","volume":"17","author":"F Fontana","year":"2021","unstructured":"Fontana F, Figueiredo P, Martins JP, Santos HA (2021) Requirements for animal experiments: problems and challenges. Small 17(15):2004182","journal-title":"Small"},{"key":"3665_CR22","doi-asserted-by":"crossref","unstructured":"Halder P, Pal U, Paladhi P, Dutta S, Paul P, Pal S, ... Ghosh S (2022) Evaluation of potency of the selected bioactive molecules from Indian medicinal plants with MPro of SARS-CoV-2 through in silico analysis. J Ayurveda Integr Med 13(2):100449","DOI":"10.1016\/j.jaim.2021.05.003"},{"issue":"2","key":"3665_CR23","doi-asserted-by":"publisher","first-page":"113","DOI":"10.17305\/bjbms.2011.2593","volume":"11","author":"A Hasani","year":"2011","unstructured":"Hasani A, Soljakova M, Jakupi M, Ustalar-Ozgen S (2011) Preemptive analgesic effects of midazolam and diclofenac in rat model. Bosn J Basic Med Sci 11(2):113\u2013118. https:\/\/doi.org\/10.17305\/bjbms.2011.2593","journal-title":"Bosn J Basic Med Sci"},{"key":"3665_CR24","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1002\/jez.2560","volume":"337","author":"SM Hoseini","year":"2022","unstructured":"Hoseini SM, Taheri Mirghaed A, Pagheh E, Hoseinifar SH, Van Doan H (2022) Anesthesia of rainbow trout with citronellal: efficacy and biochemical effects. J Exp Zool A Ecol Integr Physiol 337:227\u2013237. https:\/\/doi.org\/10.1002\/jez.2560","journal-title":"J Exp Zool A Ecol Integr Physiol"},{"issue":"1","key":"3665_CR25","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1080\/01616412.2016.1251711","volume":"39","author":"MT Islam","year":"2017","unstructured":"Islam MT (2017) Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders. Neurol Res 39(1):73\u201382. https:\/\/doi.org\/10.1080\/01616412.2016.1251711","journal-title":"Neurol Res"},{"key":"3665_CR26","doi-asserted-by":"crossref","unstructured":"Islam F, Mitra S, Nafady MH, Rahman MT, Tirth V, Akter A, ... El-Kholy SS (2022) Neuropharmacological and antidiabetic potential of lannea coromandelica (houtt.) merr. leaves extract: an experimental analysis. Hindawi Evid-Based Complement Alternat Med. 2022;2022(1):6144733","DOI":"10.1155\/2022\/6144733"},{"key":"3665_CR27","doi-asserted-by":"publisher","unstructured":"Islam F, Azad MA, Pandiyan B, Gupta JK, Darwin R, Lakshmi PA, ... Emran TB (2024) Bioactive extracts from the fruit rind of Limonia acidissima L. exhibit neuro-modulatory properties in a thiopental-sodium sleep model in Swiss albino mice: implications for neuro-pharmacological interventions. J Biol Regul Homeost Agents. https:\/\/doi.org\/10.23812\/j.biol.regul.homeost.agents.20243807.452","DOI":"10.23812\/j.biol.regul.homeost.agents.20243807.452"},{"key":"3665_CR28","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1080\/10412905.1992.9698090","volume":"4","author":"W J\u00e4ger","year":"1992","unstructured":"J\u00e4ger W, Buchbauer G, Jirovetz L, Dietrich H, Plank C (1992) Evidence of the sedative effect of neroli oil, citronellal and phenylethyl acetate on mice. J Essential Oil Res 4:387\u2013394. https:\/\/doi.org\/10.1080\/10412905.1992.9698090","journal-title":"J Essential Oil Res"},{"key":"3665_CR29","doi-asserted-by":"crossref","unstructured":"Jiang C, Chen Y, Fan M, Wang L, Shen L, Li N, ... Han T (2021) Douleur: creating pain sensation with chemical stimulant to enhance user experience in virtual reality. Proceedings of the ACM on Interactive, Mobile, Wearable and Ubiquitous Technologies 5(2):1\u201326","DOI":"10.1145\/3463527"},{"key":"3665_CR30","doi-asserted-by":"publisher","unstructured":"Kamli H, Bappi MH, Islam T, Hossain R, Hossen MM, Faruq AA, Borges JAO, Ara\u00fajo IM, Almeida RS, Coutinho HDM, Tahim CM, Lucetti ECP, Islam MT (2023) Antioxidant, anti-inflammatory, and anxiolytic-like effects of Urena sinuata L.: In vitro, in vivo, and in silico studies. J Biol Regul Homeost Agents 37(9):5035\u20135052. https:\/\/doi.org\/10.23812\/j.biol.regul.homeost.agents.20233709.489","DOI":"10.23812\/j.biol.regul.homeost.agents.20233709.489"},{"issue":"2","key":"3665_CR31","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.jep.2013.09.023","volume":"150","author":"Z Kebebew","year":"2013","unstructured":"Kebebew Z, Shibeshi W (2013) Evaluation of anxiolytic and sedative effects of 80% ethanolic Carica papaya L. (Caricaceae) pulp extract in mice. J Ethnopharmacol 150(2):665\u2013671. https:\/\/doi.org\/10.1016\/j.jep.2013.09.023","journal-title":"J Ethnopharmacol"},{"key":"3665_CR32","doi-asserted-by":"publisher","unstructured":"Kim S, Zhang J, Cheng T, Li Q, Bolton EE (2024) Glycoscience data content in the NCBI Glycans and PubChem. Anal Bioanal Chem 1\u201314. https:\/\/doi.org\/10.1007\/s00216-024-05459-7","DOI":"10.1007\/s00216-024-05459-7"},{"issue":"3","key":"3665_CR33","doi-asserted-by":"publisher","first-page":"87","DOI":"10.15713\/ins.jcri.112","volume":"3","author":"KH Kumar","year":"2016","unstructured":"Kumar KH, Elavarasi P (2016) Definition of pain and classification of pain disorders. J Advan Clin Res Insights 3(3):87\u201390. https:\/\/doi.org\/10.15713\/ins.jcri.112","journal-title":"J Advan Clin Res Insights"},{"key":"3665_CR34","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.eng.2019.07.027","volume":"6","author":"AS Li","year":"2020","unstructured":"Li AS, Iijima A, Huang J, Li QX, Chen Y (2020) Putative mode of action of the monoterpenoids linalool, methyl eugenol, estragole, and citronellal on ligand-gated ion channels. Engineering 6:541\u2013545","journal-title":"Engineering"},{"issue":"9164","key":"3665_CR35","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1016\/S0140-6736(99)01311-2","volume":"353","author":"JD Loeser","year":"1999","unstructured":"Loeser JD, Melzack R (1999) Pain: an overview. Lancet 353(9164):1607\u20131609","journal-title":"Lancet"},{"key":"3665_CR36","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1002\/humu.23738","volume":"40","author":"PB McGarvey","year":"2019","unstructured":"McGarvey PB, Nightingale A, Luo J, Huang H, Martin MJ, Wu C, UniProt Consortium (2019) UniProt genomic mapping for deciphering functional effects of missense variants. Nucleic Acids Res. 40:694\u2013705. https:\/\/doi.org\/10.1002\/humu.23738","journal-title":"Nucleic Acids Res."},{"issue":"24","key":"3665_CR37","doi-asserted-by":"publisher","first-page":"11693","DOI":"10.1073\/pnas.90.24.11693","volume":"90","author":"JA Mitchell","year":"1993","unstructured":"Mitchell JA, Akarasereenont P, Thiemermann C, Flower RJ, Vane JR (1993) Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci USA 90(24):11693\u201311697","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"3665_CR38","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neuropharm.2011.08.040","volume":"62","author":"H M\u00f6hler","year":"2012","unstructured":"M\u00f6hler H (2012) The GABA system in anxiety and depression and its therapeutic potential. Neuropharmacology 62(1):42\u201353. https:\/\/doi.org\/10.1016\/j.neuropharm.2011.08.040","journal-title":"Neuropharmacology"},{"key":"3665_CR39","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.biortech.2009.07.048","volume":"101","author":"LS Nerio","year":"2010","unstructured":"Nerio LS, Olivero-Verbel J, Stashenko E (2010) Repellent activity of essential oils: a review. Bioresour Technol 101:372\u2013378. https:\/\/doi.org\/10.1016\/j.biortech.2009.07.048","journal-title":"Bioresour Technol"},{"issue":"1","key":"3665_CR40","doi-asserted-by":"publisher","first-page":"9335","DOI":"10.1038\/s41598-021-88599-5","volume":"11","author":"M P\u00e1dua-Reis","year":"2021","unstructured":"P\u00e1dua-Reis M, N\u00f4ga DA, Tort ABL, Blunder M (2021) Diazepam causes sedative rather than anxiolytic effects in C57BL\/6J mice. Sci Rep 11(1):9335. https:\/\/doi.org\/10.1038\/s41598-021-88599-5","journal-title":"Sci Rep"},{"issue":"18","key":"3665_CR41","doi-asserted-by":"publisher","first-page":"4331","DOI":"10.3390\/ijms20184331","volume":"20","author":"L Pinzi","year":"2019","unstructured":"Pinzi L, Rastelli G (2019) Molecular docking: shifting paradigms in drug discovery. Int J Mol Sci 20(18):4331. https:\/\/doi.org\/10.3390\/ijms20184331","journal-title":"Int J Mol Sci"},{"key":"3665_CR42","doi-asserted-by":"crossref","unstructured":"Pognan F, Beilmann M, Boonen H, Czich A, Dear G, Hewitt P, ... Newham P (2023) The evolving role of investigative toxicology in the pharmaceutical industry. Nat Rev Drug Discov 22(4):317\u2013335","DOI":"10.1038\/s41573-022-00633-x"},{"issue":"1","key":"3665_CR43","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.scib.2021.09.007","volume":"67","author":"X Qin","year":"2022","unstructured":"Qin X, Pan HQ, Huang SH, Zou JX, Zheng ZH, Liu XX, You WJ, Liu ZP, Cao JL, Zhang WH, Pan BX (2022) GABAA(\u03b4) receptor hypofunction in the amygdala-hippocampal circuit underlies stress-induced anxiety. Sci Bull 67(1):97\u2013110. https:\/\/doi.org\/10.1016\/j.scib.2021.09.007","journal-title":"Sci Bull"},{"key":"3665_CR44","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1089\/jmf.2010.0125","volume":"14","author":"L Quintans-J\u00fanior","year":"2011","unstructured":"Quintans-J\u00fanior L, da Rocha RF, Caregnato FF, Moreira JC, da Silva FA, Ara\u00fajo AA, dos Santos JP, Melo MS, de Sousa DP, Bonjardim LR, Gelain DP (2011) Antinociceptive action and redox properties of citronellal, an essential oil present in lemongrass. J Med Food 14:630\u2013639. https:\/\/doi.org\/10.1089\/jmf.2010.0125","journal-title":"J Med Food"},{"issue":"1","key":"3665_CR45","doi-asserted-by":"publisher","first-page":"42","DOI":"10.31083\/j.jin2101042","volume":"21","author":"MM Rahman","year":"2022","unstructured":"Rahman MM, Islam F, Parvez A, Azad MA, Ashraf GM, Ullah MF, Ahmed M (2022) Citrus limon L. (lemon) seed extract shows neuro-modulatory activity in an in vivo thiopental-sodium sleep model by reducing the sleep onset and enhancing the sleep duration. J Integr Neurosci 21(1):42","journal-title":"J Integr Neurosci"},{"key":"3665_CR46","doi-asserted-by":"crossref","unstructured":"Revanasiddappa PD, Gowtham HG, Chikkanna GS, Gangadhar S, Murali M, Shivamallu C, ... Amruthesh KN (2024) Exploration of type III effector Xanthomonas outer protein Q (XopQ) inhibitor from Picrasma quassioides as an antibacterial agent using chemoinformatics analysis. PloS One 19(6):e0302105","DOI":"10.1371\/journal.pone.0302105"},{"key":"3665_CR47","doi-asserted-by":"publisher","unstructured":"Rose PW, Prli\u0107 A, Altunkaya A, Bi C, Bradley AR, Christie CH, Costanzo LD, Duarte JM, Dutta S, Feng Z et al (2016) The RCSB protein data bank: integrative view of protein, gene and 3D structural information. Nucleic Acids Res. gkw1000. https:\/\/doi.org\/10.1093\/nar\/gkw1000","DOI":"10.1093\/nar\/gkw1000"},{"issue":"4","key":"3665_CR48","first-page":"313","volume":"105","author":"A Sandri","year":"2014","unstructured":"Sandri A (2014) Diclofenac: update on tolerableness and spinal anti-inflammatory action. Minerva Med 105(4):313\u2013318","journal-title":"Minerva Med"},{"issue":"3","key":"3665_CR49","first-page":"167","volume":"107","author":"A Sandri","year":"2016","unstructured":"Sandri A (2016) Spinal antinflammatory action of Diclofenac. Minerva Med 107(3):167\u2013172","journal-title":"Minerva Med"},{"issue":"3","key":"3665_CR50","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1080\/17512433.2020.1738218","volume":"13","author":"ER Sauter","year":"2020","unstructured":"Sauter ER (2020) Cancer prevention and treatment using combination therapy with natural compounds. Expert Rev Clin Pharmacol 13(3):265\u2013285","journal-title":"Expert Rev Clin Pharmacol"},{"key":"3665_CR51","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.neubiorev.2017.10.021","volume":"83","author":"LM Sch\u00f6nfeld","year":"2017","unstructured":"Sch\u00f6nfeld LM, Dooley D, Jahanshahi A, Temel Y, Hendrix S (2017) Evaluating rodent motor functions: which tests to choose? Neurosci Biobehav Rev 83:298\u2013312","journal-title":"Neurosci Biobehav Rev"},{"key":"3665_CR52","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s12275-020-9563-z","volume":"58","author":"B Shaker","year":"2020","unstructured":"Shaker B, Yu MS, Lee J, Lee Y, Jung C, Na D (2020) User guide for the discovery of potential drugs via protein structure prediction and ligand docking simulation. J Microbiol 58:235\u2013244","journal-title":"J Microbiol"},{"key":"3665_CR53","doi-asserted-by":"crossref","unstructured":"Shen R, Cheng K, Li G, Pan Z, Qiaolongbatu X, Wang Y, ... Wu Z (2024) Alisol A, the eye-entering ingredient of Alisma orientale, relieves macular edema through TNF-\u03b1 as revealed by UPLC-triple-TOF\/MS, Network Pharmacology, and Zebrafish Verification. Drug Des Devel Ther 18:3361\u20133382","DOI":"10.2147\/DDDT.S468119"},{"issue":"23","key":"3665_CR54","doi-asserted-by":"publisher","first-page":"7704","DOI":"10.3390\/molecules28237704","volume":"28","author":"J Song","year":"2023","unstructured":"Song J, Zaidi SAA, He L, Zhang S, Zhou G (2023) Integrative analysis of machine learning and molecule docking simulations for ischemic stroke diagnosis and therapy. Molecules 28(23):7704","journal-title":"Molecules"},{"issue":"1","key":"3665_CR55","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/0304-3959(95)00110-E","volume":"63","author":"M Stanton-Hicks","year":"1995","unstructured":"Stanton-Hicks M, J\u00e4nig W, Hassenbusch S, Haddox J, Boas R, Wilson P (1995) Reflex sympathetic dystrophy: changing concepts and taxonomy. Pain 63(1):127\u2013133","journal-title":"Pain"},{"issue":"11","key":"3665_CR56","first-page":"1934578X2211399","volume":"17","author":"NM Stojanovi\u0107","year":"2022","unstructured":"Stojanovi\u0107 NM, Rajkovi\u0107 I, Rai\u010devi\u0107 V, Petkovi\u0107 MN, Randjelovi\u0107 PJ, Radulovi\u0107 NS (2022) Lemon balm (Melissa officinalis) essential oil moderately affects strychnine-induced and pentylenetetrazol-induced convulsions\u2014in silico and in vivo studies. Nat Prod Commun 17(11):1934578X221139961","journal-title":"Nat Prod Commun"},{"key":"3665_CR57","doi-asserted-by":"publisher","unstructured":"Subin JA, Shrestha RLS (2024) Computational assessment of the phytochemicals of Panax ginseng CA Meyer against dopamine receptor D1 for early Huntington\u2019s disease prophylactics. Cell Biochem Biophys 1\u201311. https:\/\/doi.org\/10.1007\/s12013-024-01426-2","DOI":"10.1007\/s12013-024-01426-2"},{"issue":"2","key":"3665_CR58","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.jaac.2021.11.020","volume":"61","author":"C Usher","year":"2022","unstructured":"Usher C (2022) Eco-Anxiety. J Am Acad Child Adolesc Psychiatry 61(2):341\u2013342. https:\/\/doi.org\/10.1016\/j.jaac.2021.11.020","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"3665_CR59","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.ejphar.2014.09.005","volume":"742","author":"FN Victoria","year":"2014","unstructured":"Victoria FN, Anversa R, Penteado F, Castro M, Lenard\u00e3o EJ, Savegnago L (2014) Antioxidant and antidepressant-like activities of semi-synthetic \u03b1-phenylseleno citronellal. Eur J Pharmacol 742:131\u2013138. https:\/\/doi.org\/10.1016\/j.ejphar.2014.09.005","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"3665_CR60","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1080\/03007995.2020.1716703","volume":"36","author":"PJ Wiffen","year":"2020","unstructured":"Wiffen PJ, Xia J (2020) Systematic review of topical diclofenac for the treatment of acute and chronic musculoskeletal pain. Curr Med Res Opin 36(4):637\u2013650","journal-title":"Curr Med Res Opin"},{"issue":"13","key":"3665_CR61","doi-asserted-by":"publisher","first-page":"647","DOI":"10.2147\/JIR.S267154","volume":"30","author":"T Yimer","year":"2020","unstructured":"Yimer T, Birru EM, Adugna M, Geta M, Emiru YK (2020) Evaluation of analgesic and anti-inflammatory activities of 80% methanol root extract of Echinops kebericho M. (Asteraceae). J Inflamm Res. 30(13):647\u2013658. https:\/\/doi.org\/10.2147\/JIR.S267154","journal-title":"J Inflamm Res."},{"issue":"2","key":"3665_CR62","first-page":"313","volume":"229","author":"VV Zakusov","year":"1977","unstructured":"Zakusov VV, Ostrovskaya RU, Kozhechkin SN, Markovich VV, Molodavkin GM, Voronina TA (1977) Further evidence for GABA-ergic mechanisms in the action of benzodiazepines. Arch Int Pharmacodyn Ther 229(2):313\u2013326","journal-title":"Arch Int Pharmacodyn Ther"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03665-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-024-03665-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03665-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T08:17:44Z","timestamp":1744273064000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-024-03665-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,28]]},"references-count":62,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["3665"],"URL":"https:\/\/doi.org\/10.1007\/s00210-024-03665-9","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,28]]},"assertion":[{"value":"18 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Animal Ethics Committee of Khulna University (KUAEC-2023\u201305-09). No anesthetic or surgical procedures were used for this study. We checked only the behavioral parameters after the treatment; therefore, this study did not require any medication to overcome or reduce the suffering of the experimental animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}