{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:52:59Z","timestamp":1790985179821,"version":"4.1.0"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:00:00Z","timestamp":1733097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:00:00Z","timestamp":1733097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1007\/s00210-024-03677-5","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T09:08:30Z","timestamp":1733130510000},"page":"5927-5937","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Citronellol protects renal function by exerting anti-inflammatory and antiapoptotic effects against acute kidney injury induced by folic acid in mice"],"prefix":"10.1007","volume":"398","author":[{"given":"Meera Ziyad","family":"Jamal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarmed H.","family":"Kathem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,2]]},"reference":[{"key":"3677_CR1","doi-asserted-by":"publisher","first-page":"58","DOI":"10.31351\/vol30iss2pp58-63","volume":"30","author":"BW Abbas","year":"2021","unstructured":"Abbas BW, Kathem SH (2021) Carvone attenuates irinotecan-induced intestinal mucositis and diarrhea in mice. Iraqi J Pharm Sci 30:58\u201363. https:\/\/doi.org\/10.31351\/vol30iss2pp58-63","journal-title":"Iraqi J Pharm Sci"},{"key":"3677_CR2","doi-asserted-by":"publisher","first-page":"87","DOI":"10.31351\/vol31iss1pp87-94","volume":"31","author":"MR Abd","year":"2022","unstructured":"Abd MR, Hassan AF (2022) The ameliorative effect of fimasartan against methotrexate-induced nephrotoxicity in rats. Iraqi J Pharm Sci 31:87\u201394","journal-title":"Iraqi J Pharm Sci"},{"key":"3677_CR3","doi-asserted-by":"publisher","first-page":"e23011","DOI":"10.1002\/jbt.23011","volume":"36","author":"RS Abdelrahman","year":"2022","unstructured":"Abdelrahman RS, Abdelsalam RA, Zaghloul MS (2022) Beneficial effect of trimetazidine on folic acid-induced acute kidney injury in mice: Role of HIF-1\u03b1\/HO-1. J Biochem Mol Toxicol 36:e23011. https:\/\/doi.org\/10.1002\/jbt.23011","journal-title":"J Biochem Mol Toxicol"},{"key":"3677_CR4","doi-asserted-by":"publisher","first-page":"15672","DOI":"10.1038\/s41598-021-94946-3","volume":"11","author":"A Abebe","year":"2021","unstructured":"Abebe A, Kumela K, Belay M, Kebede B, Wobie Y (2021) Mortality and predictors of acute kidney injury in adults: a hospital-based prospective observational study. Sci Rep 11:15672. https:\/\/doi.org\/10.1038\/s41598-021-94946-3","journal-title":"Sci Rep"},{"key":"3677_CR5","doi-asserted-by":"publisher","first-page":"50","DOI":"10.31351\/vol30iss2pp50-57","volume":"30","author":"HA Ahmad","year":"2021","unstructured":"Ahmad HA, Kathem SH (2021) Thymoquinone attenuates immune mediated liver injury induced by concanavalin A in mice. Iraqi J Pharm Sci 30:50\u201357. https:\/\/doi.org\/10.31351\/vol30iss2pp50-57","journal-title":"Iraqi J Pharm Sci"},{"key":"3677_CR6","doi-asserted-by":"publisher","first-page":"14","DOI":"10.30539\/ijvm.v44i(E0).1014","volume":"44","author":"AM Al-ghareebaw","year":"2020","unstructured":"Al-ghareebaw AM, Al-Okaily BN, Ibrahim OMS, Mohammed AD (2020) Role of olive leaves zinc oxide nanoparticles in alleviating the molecular and histological changes of kidney in female goats-induced by gentamicin (Part III). The Iraqi J Veter Med 44:14\u201320","journal-title":"The Iraqi J Veter Med"},{"key":"3677_CR7","doi-asserted-by":"publisher","first-page":"109842","DOI":"10.1016\/j.cbi.2022.109842","volume":"354","author":"KS Alharbi","year":"2022","unstructured":"Alharbi KS, Afzal O, Almalki WH, Kazmi I, Javed Shaikh MA, Thangavelu L, Gulati M, Singh SK, Jha NK, Gupta PK, Chellappan DK, Oliver BG, Dua K, Gupta G (2022) Nuclear factor-kappa B (NF-\u03baB) inhibition as a therapeutic target for plant nutraceuticals in mitigating inflammatory lung diseases. Chemico-biological Interact 354:109842. https:\/\/doi.org\/10.1016\/j.cbi.2022.109842","journal-title":"Chemico-biological Interact"},{"key":"3677_CR8","doi-asserted-by":"publisher","first-page":"274","DOI":"10.31351\/vol32iss1pp274-282","volume":"32","author":"L Al-Hasani","year":"2023","unstructured":"Al-Hasani L, Ghaith AJ, Ihsan SR (2023) Evaluation of renoprotective effect of lipoic acid and bosentan against diclofenac-induced acute renal failure. Iraqi J Pharm Sci 32:274\u2013282","journal-title":"Iraqi J Pharm Sci"},{"key":"3677_CR9","doi-asserted-by":"publisher","first-page":"112","DOI":"10.31351\/vol32iss2pp112-119","volume":"32","author":"B Alkhazragy","year":"2023","unstructured":"Alkhazragy B, Alshawi NN (2023) Protective effect of cranberry extract against cisplatin-induced nephrotoxicity by improving oxidative stress in mice. Iraqi J Pharm Sci 32:112\u2013119","journal-title":"Iraqi J Pharm Sci"},{"key":"3677_CR10","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.freeradbiomed.2018.11.005","volume":"130","author":"OE Aparicio-Trejo","year":"2019","unstructured":"Aparicio-Trejo OE, Reyes-Ferm\u00edn LM, Briones-Herrera A, Tapia E, Le\u00f3n-Contreras JC, Hern\u00e1ndez-Pando R, S\u00e1nchez-Lozada LG, Pedraza-Chaverri J (2019) Protective effects of N-acetyl-cysteine in mitochondria bioenergetics, oxidative stress, dynamics and S-glutathionylation alterations in acute kidney damage induced by folic acid. Free Radic Biol Med 130:379\u2013396. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2018.11.005","journal-title":"Free Radic Biol Med"},{"key":"3677_CR11","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1007\/s11418-012-0632-4","volume":"66","author":"RG Brito","year":"2012","unstructured":"Brito RG, Guimar\u00e3es AG, Quintans JS, Santos MR, De Sousa DP, Badaue-Passos D Jr, de Lucca W, Brito FA Jr, Barreto EO, Oliveira AP, Quintans LJ Jr (2012) Citronellol, a monoterpene alcohol, reduces nociceptive and inflammatory activities in rodents. J Nat Med 66:637\u201344. https:\/\/doi.org\/10.1007\/s11418-012-0632-4","journal-title":"J Nat Med"},{"key":"3677_CR12","doi-asserted-by":"publisher","first-page":"4058","DOI":"10.2174\/092986709789378206","volume":"16","author":"P Caroppi","year":"2009","unstructured":"Caroppi P, Sinibaldi F, Fiorucci L, Santucci R (2009) Apoptosis and human diseases: mitochondrion damage and lethal role of released cytochrome C as proapoptotic protein. Curr Med Chem 16:4058\u201365. https:\/\/doi.org\/10.2174\/092986709789378206","journal-title":"Curr Med Chem"},{"key":"3677_CR13","doi-asserted-by":"publisher","first-page":"20676","DOI":"10.1074\/jbc.M002328200","volume":"275","author":"CD Chancy","year":"2000","unstructured":"Chancy CD, Kekuda R, Huang W, Prasad PD, Kuhnel JM, Sirotnak FM, Roon P, Ganapathy V, Smith SB (2000) Expression and differential polarization of the reduced-folate transporter-1 and the folate receptor alpha in mammalian retinal pigment epithelium. J Biol Chem 275:20676\u201384. https:\/\/doi.org\/10.1074\/jbc.M002328200","journal-title":"J Biol Chem"},{"key":"3677_CR14","doi-asserted-by":"publisher","first-page":"303","DOI":"10.4103\/0976-500x.119726","volume":"4","author":"J Charan","year":"2013","unstructured":"Charan J, Kantharia ND (2013) How to calculate sample size in animal studies? J Pharmacol Pharmacother 4:303\u20136. https:\/\/doi.org\/10.4103\/0976-500x.119726","journal-title":"J Pharmacol Pharmacother"},{"key":"3677_CR15","doi-asserted-by":"publisher","first-page":"153","DOI":"10.3389\/fphys.2019.00153","volume":"10","author":"Y Dong","year":"2019","unstructured":"Dong Y, Zhang Q, Wen J, Chen T, He L, Wang Y, Yin J, Wu R, Xue R, Li S, Fan Y, Wang N (2019) Ischemic duration and frequency determines aki-to-ckd progression monitored by dynamic changes of tubular biomarkers in IRI mice. Front Physiol 10:153. https:\/\/doi.org\/10.3389\/fphys.2019.00153","journal-title":"Front Physiol"},{"key":"3677_CR16","first-page":"62","volume":"6","author":"MM Estabraq","year":"2010","unstructured":"Estabraq MM (2010) The influences of aminophylline and indomethacin in glycerol-induced acute renal failure in rats. Al-Kindy College Med J 6:62\u201370","journal-title":"Al-Kindy College Med J"},{"key":"3677_CR17","doi-asserted-by":"publisher","first-page":"e22692","DOI":"10.1002\/jbt.22692","volume":"35","author":"DM Ezzat","year":"2021","unstructured":"Ezzat DM, Soliman AM, El-Kashef DH (2021) Nicorandil mitigates folic acid-induced nephrotoxicity in mice: Role of iNOS and eNOS. J Biochem Mol Toxicol 35:e22692. https:\/\/doi.org\/10.1002\/jbt.22692","journal-title":"J Biochem Mol Toxicol"},{"key":"3677_CR18","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3758\/bf03193146","volume":"39","author":"F Faul","year":"2007","unstructured":"Faul F, Erdfelder E, Lang AG, Buchner A (2007) G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 39:175\u201391. https:\/\/doi.org\/10.3758\/bf03193146","journal-title":"Behav Res Methods"},{"key":"3677_CR19","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1093\/ilar.47.1.5","volume":"47","author":"MFW Festing","year":"2006","unstructured":"Festing MFW (2006) Design and statistical methods in studies using animal models of development. ILAR J. 47:5\u201314. https:\/\/doi.org\/10.1093\/ilar.47.1.5","journal-title":"ILAR J."},{"key":"3677_CR20","doi-asserted-by":"publisher","first-page":"100120","DOI":"10.1016\/j.metip.2023.100120","volume":"8","author":"MA Garc\u00eda-P\u00e9rez","year":"2023","unstructured":"Garc\u00eda-P\u00e9rez MA (2023) Use and misuse of corrections for multiple testing. Methods in Psychology 8:100120. https:\/\/doi.org\/10.1016\/j.metip.2023.100120","journal-title":"Methods in Psychology"},{"key":"3677_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pharmthera.2019.04.001","volume":"200","author":"SR Gonsalez","year":"2019","unstructured":"Gonsalez SR, Cort\u00eas AL, Silva RCD, Lowe J, Prieto MC, Silva Lara LD (2019) Acute kidney injury overview: From basic findings to new prevention and therapy strategies. Pharmacol Ther 200:1\u201312. https:\/\/doi.org\/10.1016\/j.pharmthera.2019.04.001","journal-title":"Pharmacol Ther"},{"key":"3677_CR22","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1097\/ftd.0000000000000589","volume":"41","author":"BR Griffin","year":"2019","unstructured":"Griffin BR, Faubel S, Edelstein CL (2019) Biomarkers of drug-induced kidney toxicity. Ther Drug Monit 41:213\u2013226. https:\/\/doi.org\/10.1097\/ftd.0000000000000589","journal-title":"Ther Drug Monit"},{"key":"3677_CR23","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.etp.2010.08.010","volume":"64","author":"A Gupta","year":"2012","unstructured":"Gupta A, Puri V, Sharma R, Puri S (2012) Folic acid induces acute renal failure (ARF) by enhancing renal prooxidant state. Exp Toxicol Pathol 64:225\u201332. https:\/\/doi.org\/10.1016\/j.etp.2010.08.010","journal-title":"Exp Toxicol Pathol"},{"key":"3677_CR24","doi-asserted-by":"publisher","first-page":"F105","DOI":"10.1152\/ajprenal.00140.2023","volume":"326","author":"AK Hamid","year":"2024","unstructured":"Hamid AK, Pastor Arroyo EM, Lee SS, Wagner CA, Egli-Spichtig D (2024) A novel method for automated crystal visualization and quantification in murine folic acid-induced acute kidney injury. Am J Physiol Renal Physiol 326:F105-f117. https:\/\/doi.org\/10.1152\/ajprenal.00140.2023","journal-title":"Am J Physiol Renal Physiol"},{"key":"3677_CR25","doi-asserted-by":"publisher","first-page":"F1030","DOI":"10.1152\/ajprenal.00022.2021","volume":"320","author":"J Huang","year":"2021","unstructured":"Huang J, Bayliss G, Zhuang S (2021) Porcine models of acute kidney injury. Am J Physiol-Renal Physiol 320:F1030\u2013F1044","journal-title":"Am J Physiol-Renal Physiol"},{"key":"3677_CR26","doi-asserted-by":"publisher","first-page":"11131","DOI":"10.1038\/s41598-024-61269-y","volume":"14","author":"ZA Hussein","year":"2024","unstructured":"Hussein ZA, Abu-Raghif AR, Tahseen NJ, Rashed KA, Shaker NS, Fawzi HA (2024) Vinpocetine alleviated alveolar epithelial cells injury in experimental pulmonary fibrosis by targeting PPAR-\u03b3\/NLRP3\/NF-\u03baB and TGF-\u03b21\/Smad2\/3 pathways. Sci Rep 14:11131. https:\/\/doi.org\/10.1038\/s41598-024-61269-y","journal-title":"Sci Rep"},{"key":"3677_CR27","doi-asserted-by":"publisher","first-page":"e22441","DOI":"10.1002\/jbt.22441","volume":"34","author":"R Jayaganesh","year":"2020","unstructured":"Jayaganesh R, Pugalendhi P, Murali R (2020) Effect of citronellol on NF-kB inflammatory signaling molecules in chemical carcinogen-induced mammary cancer in the rat model. J Biochem Mol Toxicol 34:e22441. https:\/\/doi.org\/10.1002\/jbt.22441","journal-title":"J Biochem Mol Toxicol"},{"key":"3677_CR28","doi-asserted-by":"publisher","first-page":"e11434","DOI":"10.1016\/j.heliyon.2022.e11434","volume":"8","author":"RL Jayaraj","year":"2022","unstructured":"Jayaraj RL, Azimullah S, Parekh KA, Ojha SK, Beiram R (2022) Effect of citronellol on oxidative stress, neuroinflammation and autophagy pathways in an in vivo model of Parkinson\u2019s disease. Heliyon 8:e11434. https:\/\/doi.org\/10.1016\/j.heliyon.2022.e11434","journal-title":"Heliyon"},{"key":"3677_CR29","doi-asserted-by":"publisher","first-page":"F1252","DOI":"10.1152\/ajprenal.00128.2018","volume":"315","author":"K Jiang","year":"2018","unstructured":"Jiang K, Ponzo TA, Tang H, Mishra PK, Macura SI, Lerman LO (2018) Multiparametric MRI detects longitudinal evolution of folic acid-induced nephropathy in mice. Am J Physiol Renal Physiol 315:F1252-f1260. https:\/\/doi.org\/10.1152\/ajprenal.00128.2018","journal-title":"Am J Physiol Renal Physiol"},{"key":"3677_CR30","doi-asserted-by":"publisher","first-page":"880","DOI":"10.3389\/fphar.2019.00880","volume":"10","author":"M Jiang","year":"2019","unstructured":"Jiang M, Fan J, Qu X, Li S, Nilsson SK, Sun YBY, Chen Y, Yu D, Liu D, Liu BC, Tang M, Chen W, Ren Y, Nikolic-Paterson DJ, Jiang X, Li J, Yu X (2019) Combined blockade of Smad3 and JNK pathways ameliorates progressive fibrosis in folic acid nephropathy. Front Pharmacol 10:880. https:\/\/doi.org\/10.3389\/fphar.2019.00880","journal-title":"Front Pharmacol"},{"key":"3677_CR31","doi-asserted-by":"publisher","first-page":"30","DOI":"10.23876\/j.krcp.2018.37.1.30","volume":"37","author":"JH Jung","year":"2018","unstructured":"Jung JH, Choi JE, Song JH, Ahn SH (2018) Human CD36 overexpression in renal tubules accelerates the progression of renal diseases in a mouse model of folic acid-induced acute kidney injury. Kidney Res Clin Pract 37:30\u201340. https:\/\/doi.org\/10.23876\/j.krcp.2018.37.1.30","journal-title":"Kidney Res Clin Pract"},{"key":"3677_CR32","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-024-03359-2","author":"AW Khafaji","year":"2024","unstructured":"Khafaji AW, Al-Zubaidy AA, Farhood IG, Fawzi HA (2024) Effects of topical isoxsuprine ointment on imiquimod-induced psoriasiform skin inflammation in mice. Naunyn Schmiedebergs Arch Pharmacol. https:\/\/doi.org\/10.1007\/s00210-024-03359-2","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"3677_CR33","doi-asserted-by":"publisher","first-page":"e115947","DOI":"10.1371\/journal.pone.0115947","volume":"10","author":"D Kumar","year":"2015","unstructured":"Kumar D, Singla SK, Puri V, Puri S (2015) The restrained expression of NF-kB in renal tissue ameliorates folic acid induced acute kidney injury in mice. PLoS One 10:e115947. https:\/\/doi.org\/10.1371\/journal.pone.0115947","journal-title":"PLoS One"},{"key":"3677_CR34","doi-asserted-by":"publisher","first-page":"6286984","DOI":"10.1155\/2020\/6286984","volume":"2020","author":"X Li","year":"2020","unstructured":"Li X, Zou Y, Xing J, Fu Y-Y, Wang K-Y, Wan P-Z, Zhai X-Y (2020) Pretreatment with Roxadustat (FG-4592) attenuates folic acid-induced kidney injury through antiferroptosis via Akt\/GSK-3\u03b2\/Nrf2 pathway. Oxid Med Cell Long 2020:6286984. https:\/\/doi.org\/10.1155\/2020\/6286984","journal-title":"Oxid Med Cell Long"},{"key":"3677_CR35","doi-asserted-by":"publisher","first-page":"650283","DOI":"10.3389\/fphar.2021.650283","volume":"12","author":"X Li","year":"2021","unstructured":"Li X, Zou Y, Fu YY, Xing J, Wang KY, Wan PZ, Wang M, Zhai XY (2021) Ibudilast attenuates folic acid-induced acute kidney injury by blocking pyroptosis through TLR4-Mediated NF-\u03baB and MAPK signaling pathways. Front Pharmacol 12:650283. https:\/\/doi.org\/10.3389\/fphar.2021.650283","journal-title":"Front Pharmacol"},{"key":"3677_CR36","doi-asserted-by":"publisher","first-page":"680544","DOI":"10.3389\/fphys.2021.680544","volume":"12","author":"X Li","year":"2021","unstructured":"Li X, Zou Y, Fu YY, Xing J, Wang KY, Wan PZ, Zhai XY (2021) A-lipoic acid alleviates folic acid-induced renal damage through inhibition of ferroptosis. Front Physiol 12:680544. https:\/\/doi.org\/10.3389\/fphys.2021.680544","journal-title":"Front Physiol"},{"key":"3677_CR37","doi-asserted-by":"publisher","first-page":"1043945","DOI":"10.3389\/fphar.2022.1043945","volume":"13","author":"J Li","year":"2022","unstructured":"Li J, Jiang Y, Dai Q, Yu Y, Lv X, Zhang Y, Liao X, Ao L, Hu G, Meng J, Peng Z, Tao L, Xie Y (2022) Protective effects of mefunidone on ischemia-reperfusion injury\/Folic acid-induced acute kidney injury. Front Pharmacol 13:1043945. https:\/\/doi.org\/10.3389\/fphar.2022.1043945","journal-title":"Front Pharmacol"},{"key":"3677_CR38","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402\u20138. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"3677_CR39","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.25122\/jml-2023-0102","volume":"16","author":"YS Mahmood","year":"2023","unstructured":"Mahmood YS, Kathem SH (2023) Protective effect of citronellol in rhabdomyolysis-induced acute kidney injury in mice. J Med Life 16:1057\u20131061. https:\/\/doi.org\/10.25122\/jml-2023-0102","journal-title":"J Med Life"},{"key":"3677_CR40","doi-asserted-by":"publisher","first-page":"323","DOI":"10.2147\/ijnrd.S386396","volume":"15","author":"LW Maines","year":"2022","unstructured":"Maines LW, Green CL, Keller SN, Fitzpatrick LR, Smith CD (2022) The sphingosine kinase 2 inhibitor opaganib protects against acute kidney injury in mice. Int J Nephrol Renovasc Dis 15:323\u2013334. https:\/\/doi.org\/10.2147\/ijnrd.S386396","journal-title":"Int J Nephrol Renovasc Dis"},{"key":"3677_CR41","doi-asserted-by":"publisher","first-page":"117729","DOI":"10.1016\/j.lfs.2020.117729","volume":"253","author":"MN Makled","year":"2020","unstructured":"Makled MN, El-Kashef DH (2020) Saroglitazar attenuates renal fibrosis induced by unilateral ureteral obstruction via inhibiting TGF-\u03b2\/Smad signaling pathway. Life Sci 253:117729. https:\/\/doi.org\/10.1016\/j.lfs.2020.117729","journal-title":"Life Sci"},{"key":"3677_CR42","doi-asserted-by":"publisher","first-page":"2820","DOI":"10.3390\/biomedicines11102820","volume":"11","author":"S Munir","year":"2023","unstructured":"Munir S, Hafeez R, Younis W, Malik MNH, Munir MU, Manzoor W, Razzaq MA, Pessoa LB, Lopes KS, L\u00edvero FADR, Gasparotto Junior A (2023) The protective effect of citronellol against doxorubicin-induced cardiotoxicity in rats. Biomedicines 11:2820","journal-title":"Biomedicines"},{"key":"3677_CR43","doi-asserted-by":"publisher","first-page":"85","DOI":"10.31351\/vol32issSuppl.pp85-90","volume":"32","author":"Y Nasrawi","year":"2023","unstructured":"Nasrawi Y, Kadhim SH (2023) Protective effects of citronellol against rhabdomyolysis-induced acute kidney injury in mice by inhibiting NF-\u03baB and IL-1\u03b2. Iraqi J Pharm Sci 32:85\u201390. https:\/\/doi.org\/10.31351\/vol32issSuppl.pp85-90","journal-title":"Iraqi J Pharm Sci"},{"key":"3677_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3897\/pharmacia.71.e116184","volume":"71","author":"KA Obaid","year":"2024","unstructured":"Obaid KA, Fawzi HA (2024) Evaluation of empagliflozin efficacy as a promising anti-aging treatment in mice: In-vivo study. Pharmacia 71:1\u20139. https:\/\/doi.org\/10.3897\/pharmacia.71.e116184","journal-title":"Pharmacia"},{"key":"3677_CR45","doi-asserted-by":"publisher","first-page":"e3000411","DOI":"10.1371\/journal.pbio.3000411","volume":"18","author":"N Percie du Sert","year":"2020","unstructured":"Percie du Sert N, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M, Garner P, Holgate ST, Howells DW, Hurst V, Karp NA, Lazic SE, Lidster K, MacCallum CJ, Macleod M, Pearl EJ, Petersen OH, Rawle F, Reynolds P, Rooney K, Sena ES, Silberberg SD, Steckler T, W\u00fcrbel H (2020) Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 20. PLOS Biol 18:e3000411. https:\/\/doi.org\/10.1371\/journal.pbio.3000411","journal-title":"PLOS Biol"},{"key":"3677_CR46","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/bcpt.12774","volume":"121","author":"P Pierozan","year":"2017","unstructured":"Pierozan P, Jerner\u00e9n F, Ransome Y, Karlsson O (2017) The Choice of euthanasia method affects metabolic serum biomarkers. Basic Clin Pharmacol Toxicol 121:113\u2013118. https:\/\/doi.org\/10.1111\/bcpt.12774","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"3677_CR47","doi-asserted-by":"publisher","unstructured":"Priante G, Gianesello L, Ceol M, Del Prete D, Anglani F (2019) Cell death in the kidney. Int J Mol Sci 20. https:\/\/doi.org\/10.3390\/ijms20143598","DOI":"10.3390\/ijms20143598"},{"key":"3677_CR48","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1007\/s11033-024-09212-2","volume":"51","author":"S Rahimi Monfared","year":"2024","unstructured":"Rahimi Monfared S, Valibeik A, Tavakoli Dastjerd N, Jafaripour L, Jafarian A, Nabi Moradi M, Ahmadvand H (2024) Protective role of citronellol on antioxidant enzymes and oxidative damage induced by gentamicin in experimental nephrotoxic rats. Mol Biol Rep 51:382. https:\/\/doi.org\/10.1007\/s11033-024-09212-2","journal-title":"Mol Biol Rep"},{"key":"3677_CR49","doi-asserted-by":"publisher","first-page":"14","DOI":"10.31351\/vol32iss3pp14-24","volume":"32","author":"A Rashed","year":"2023","unstructured":"Rashed A, Mohamed AS, Soliman A (2023) Ameliorative effect of galium verum (rubiaceae family) methanolic extract on folic acid-induced acute kidney injury in male rats. Iraqi J Pharm Sci 32:14\u201324","journal-title":"Iraqi J Pharm Sci"},{"key":"3677_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1096\/fasebj.2022.36.S1.L7816","volume":"36","author":"SM Redha","year":"2022","unstructured":"Redha SM, Kathem SH (2022) Citronellol exerts lung protective and anti-inflammatory effects through hampering NF-\u03baB in lipopolysaccharide-induced acute lung injury in mice. FASEB J 36:1\u201310. https:\/\/doi.org\/10.1096\/fasebj.2022.36.S1.L7816","journal-title":"FASEB J"},{"key":"3677_CR51","doi-asserted-by":"publisher","unstructured":"Sabry D, AL-Zobaidy M (2024) Oral pre-treatment with Citronellol ameliorates Methotrexate-induced nephrotoxicity in Wistar rats via targeting oxidative stress and inflammation [version 1; peer review: awaiting peer review]. F1000Research 13:1\u201312. https:\/\/doi.org\/10.12688\/f1000research.156625.1","DOI":"10.12688\/f1000research.156625.1"},{"key":"3677_CR52","doi-asserted-by":"publisher","first-page":"2353","DOI":"10.3390\/nu11102353","volume":"11","author":"SL Samodelov","year":"2019","unstructured":"Samodelov SL, Gai Z, Kullak-Ublick GA, Visentin M (2019) Renal reabsorption of folates: pharmacological and toxicological snapshots. Nutrients 11:2353. https:\/\/doi.org\/10.3390\/nu11102353","journal-title":"Nutrients"},{"key":"3677_CR53","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1093\/ckj\/sfv069","volume":"8","author":"SM Sancho-Mart\u00ednez","year":"2015","unstructured":"Sancho-Mart\u00ednez SM, L\u00f3pez-Novoa JM, L\u00f3pez-Hern\u00e1ndez FJ (2015) Pathophysiological role of different tubular epithelial cell death modes in acute kidney injury. Clin Kidney J 8:548\u201359. https:\/\/doi.org\/10.1093\/ckj\/sfv069","journal-title":"Clin Kidney J"},{"key":"3677_CR54","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1007\/s12640-022-00558-8","volume":"40","author":"J Shao","year":"2022","unstructured":"Shao J, Liu X, Lian M, Mao Y (2022) Citronellol prevents 6-OHDA-induced oxidative stress, mitochondrial dysfunction, and apoptosis in parkinson disease model of SH-SY5Y cells via modulating ROS-NO, MAPK\/ERK, and PI3K\/Akt signaling pathways. Neurotox Res 40:2221\u20132237. https:\/\/doi.org\/10.1007\/s12640-022-00558-8","journal-title":"Neurotox Res"},{"key":"3677_CR55","doi-asserted-by":"publisher","first-page":"135","DOI":"10.47750\/pnr.2022.13.04.018","volume":"13","author":"SM Shareef","year":"2022","unstructured":"Shareef SM, Kathem SH (2022) Gentiopicroside ameliorates lipopolysaccharide-induced acute kidney injury by inhibiting TLR4\/NF-\u03baB signaling in mice model. J Pharm Neg Res 13:135\u2013145. https:\/\/doi.org\/10.47750\/pnr.2022.13.04.018","journal-title":"J Pharm Neg Res"},{"key":"3677_CR56","first-page":"188","volume":"6","author":"SM Shareef","year":"2024","unstructured":"Shareef SM, Kathem SH (2024) L-Carvone ameliorates lipopolysaccharide-induced acute kidney injury in mice model. Afr J Bio Sc 6:188\u2013207","journal-title":"Afr J Bio Sc"},{"key":"3677_CR57","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.jare.2020.07.007","volume":"28","author":"Y Wang","year":"2021","unstructured":"Wang Y, Quan F, Cao Q, Lin Y, Yue C, Bi R, Cui X, Yang H, Yang Y, Birnbaumer L, Li X, Gao X (2021) Quercetin alleviates acute kidney injury by inhibiting ferroptosis. J Adv Res 28:231\u2013243. https:\/\/doi.org\/10.1016\/j.jare.2020.07.007","journal-title":"J Adv Res"},{"key":"3677_CR58","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1002\/ame2.12194","volume":"4","author":"LJ Yan","year":"2021","unstructured":"Yan LJ (2021) Folic acid-induced animal model of kidney disease. Animal Model Exp Med 4:329\u2013342. https:\/\/doi.org\/10.1002\/ame2.12194","journal-title":"Animal Model Exp Med"},{"key":"3677_CR59","unstructured":"Yong L (1992) The Theory and Practice of Histological Techniques| The Theory and Practice of Histological Techniques, John D. Bancroft, Alan Stevens (Eds.), Churchill Livingstone, Edinburgh, London, Melbourne, New York (1990), p. xiv+ 726, ISBN 0-443-03559-8, $165. Elsevier"},{"key":"3677_CR60","doi-asserted-by":"publisher","first-page":"152303","DOI":"10.1016\/j.tox.2019.152303","volume":"427","author":"MS Zaghloul","year":"2019","unstructured":"Zaghloul MS, Abdelrahman RS (2019) Nilotinib ameliorates folic acid-induced acute kidney injury through modulation of TWEAK and HSP-70 pathways. Toxicology 427:152303. https:\/\/doi.org\/10.1016\/j.tox.2019.152303","journal-title":"Toxicology"},{"key":"3677_CR61","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1159\/000501934","volume":"44","author":"W Zhang","year":"2019","unstructured":"Zhang W, Yang Y, Gao H, Zhang Y, Jia Z, Huang S (2019) Inhibition of mitochondrial complex I aggravates folic acid-induced acute kidney injury. Kidney Blood Press Res 44:1002\u20131013. https:\/\/doi.org\/10.1159\/000501934","journal-title":"Kidney Blood Press Res"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03677-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-024-03677-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03677-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T08:17:46Z","timestamp":1744273066000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-024-03677-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,2]]},"references-count":61,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["3677"],"URL":"https:\/\/doi.org\/10.1007\/s00210-024-03677-5","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,2]]},"assertion":[{"value":"15 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The College of Pharmacy, University of Baghdad\u2019s ethical committee approved it before the study started.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}