{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:21:49Z","timestamp":1788909709171,"version":"build-2803163510"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"R&D Program of Guangxi Province of China","award":["AB23026088"],"award-info":[{"award-number":["AB23026088"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s00210-024-03742-z","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T02:37:09Z","timestamp":1735007829000},"page":"7155-7170","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Quercetin rescues dihydrotestosterone-treated human dermal papilla cells via SHP2\/AKT signaling to suppress autophagy and apoptosis"],"prefix":"10.1007","volume":"398","author":[{"given":"Ting","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youkun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijian","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"3742_CR1","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13013","volume":"54","author":"CM Abreu","year":"2021","unstructured":"Abreu CM, Reis RL, Marques AP (2021) Dermal papilla cells and melanocytes response to physiological oxygen levels depends on their interactions. Cell Prolif 54:e13013","journal-title":"Cell Prolif"},{"key":"3742_CR2","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/jdv.17079","volume":"35","author":"A Alessandrini","year":"2021","unstructured":"Alessandrini A, Bruni F, Piraccini BM, Starace M (2021) Common causes of hair loss - clinical manifestations, trichoscopy and therapy. J Eur Acad Dermatol Venereol JEADV 35:629\u2013640","journal-title":"J Eur Acad Dermatol Venereol JEADV"},{"key":"3742_CR3","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.114068","volume":"229","author":"SR Alizadeh","year":"2022","unstructured":"Alizadeh SR, Ebrahimzadeh MA (2022) Quercetin derivatives: Drug design, development, and biological activities, a review. Eur J Med Chem 229:114068","journal-title":"Eur J Med Chem"},{"key":"3742_CR4","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4103\/0973-7847.194044","volume":"10","author":"AV Anand David","year":"2016","unstructured":"Anand David AV, Arulmoli R, Parasuraman S (2016) Overviews of biological importance of quercetin: a bioactive flavonoid. Pharmacogn Rev 10:84\u201389","journal-title":"Pharmacogn Rev"},{"key":"3742_CR5","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1165\/rcmb.2018-0049TR","volume":"59","author":"Y Aschner","year":"2018","unstructured":"Aschner Y, Downey GP (2018) The importance of tyrosine phosphorylation control of cellular signaling pathways in respiratory disease: pY and pY Not. Am J Respir Cell Mol Biol 59:535\u2013547","journal-title":"Am J Respir Cell Mol Biol"},{"key":"3742_CR6","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1055\/a-1999-7600","volume":"73","author":"A Bagheri","year":"2023","unstructured":"Bagheri A, Radman G, Aria N, Rezaei F, Khajenouri M, Ghiabi S, Bagheri Y (2023) The effects of quercetin on apoptosis and antioxidant activity in a renal ischemia\/reperfusion injury animal model. Drug Res 73:255\u2013262","journal-title":"Drug Res"},{"key":"3742_CR7","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1002\/ar.22594","volume":"295","author":"K Baker","year":"2012","unstructured":"Baker K, Staecker H (2012) Low dose oxidative stress induces mitochondrial damage in hair cells. Anat Rec 295:1868\u20131876","journal-title":"Anat Rec"},{"key":"3742_CR8","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1080\/08923973.2021.1966032","volume":"43","author":"R Chai","year":"2021","unstructured":"Chai R, Xu C, Lu L, Liu X, Ma Z (2021) Quercetin inhibits proliferation of and induces apoptosis in non-small-cell lung carcinoma via the lncRNA SNHG7\/miR-34a-5p pathway. Immunopharmacol Immunotoxicol 43:693\u2013703","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"3742_CR9","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1182\/blood-2006-07-028829","volume":"109","author":"RJ Chan","year":"2007","unstructured":"Chan RJ, Feng GS (2007) PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase. Blood 109:862\u2013867","journal-title":"Blood"},{"key":"3742_CR10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4103\/2229-5178.148925","volume":"6","author":"BS Chandrashekar","year":"2015","unstructured":"Chandrashekar BS, Nandhini T, Vasanth V, Sriram R, Navale S (2015) Topical minoxidil fortified with finasteride: an account of maintenance of hair density after replacing oral finasteride. Indian Dermatol Online J 6:17\u201320","journal-title":"Indian Dermatol Online J"},{"key":"3742_CR11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/iub.2559","volume":"74","author":"CJ Chang","year":"2022","unstructured":"Chang CJ, Lin CF, Chen BC, Lin PY, Chen CL (2022) SHP2: The protein tyrosine phosphatase involved in chronic pulmonary inflammation and fibrosis. IUBMB Life 74:131\u2013142","journal-title":"IUBMB Life"},{"key":"3742_CR12","volume":"182","author":"S Chen","year":"2023","unstructured":"Chen S, Xu T, Xu A, Chu J, Luo D, Shi G, Li S (2023) Quercetin alleviates zearalenone-induced apoptosis and necroptosis of porcine renal epithelial cells by inhibiting CaSR\/CaMKII signaling pathway. Food Chem Toxicol 182:114184","journal-title":"Food Chem Toxicol"},{"key":"3742_CR13","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nature18621","volume":"535","author":"YN Chen","year":"2016","unstructured":"Chen YN, LaMarche MJ, Chan HM, Fekkes P, Garcia-Fortanet J, Acker MG, Antonakos B, Chen CH, Chen Z, Cooke VG et al (2016) Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Nature 535:148\u2013152","journal-title":"Nature"},{"key":"3742_CR14","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/j.jid.2016.03.032","volume":"136","author":"EGY Chew","year":"2016","unstructured":"Chew EGY, Tan JHJ, Bahta AW, Ho BS, Liu X, Lim TC, Sia YY, Bigliardi PL, Heilmann S, Wan ACA et al (2016) Differential expression between human dermal papilla cells from balding and non-balding scalps reveals new candidate genes for androgenetic alopecia. J Invest Dermatol 136:1559\u20131567","journal-title":"J Invest Dermatol"},{"issue":"9","key":"3742_CR15","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.3390\/ijms19092703","volume":"19","author":"BY Choi","year":"2018","unstructured":"Choi BY (2018) Hair-growth potential of ginseng and its major metabolites: a review on its molecular mechanisms. Int J Mol Sci 19(9):2703","journal-title":"Int J Mol Sci"},{"issue":"14","key":"3742_CR16","doi-asserted-by":"crossref","first-page":"4915","DOI":"10.3390\/ijms21144915","volume":"21","author":"BY Choi","year":"2020","unstructured":"Choi BY (2020) Targeting Wnt\/beta-catenin pathway for developing therapies for hair loss. Int J Mol Sci 21(14):4915","journal-title":"Int J Mol Sci"},{"key":"3742_CR17","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.tcb.2014.10.001","volume":"25","author":"RR Driskell","year":"2015","unstructured":"Driskell RR, Watt FM (2015) Understanding fibroblast heterogeneity in the skin. Trends Cell Biol 25:92\u201399","journal-title":"Trends Cell Biol"},{"key":"3742_CR18","volume":"441","author":"NJ Fu","year":"2022","unstructured":"Fu NJ, Xi RY, Shi XK, Li RZ, Zhang ZH, Li LY, Zhang GL, Wang F (2022) Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS\/MEK\/ERK and PI3K\/AKT signaling pathways. Toxicol Appl Pharmacol 441:115988","journal-title":"Toxicol Appl Pharmacol"},{"key":"3742_CR19","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.2147\/IJN.S104701","volume":"11","author":"P Ganesan","year":"2016","unstructured":"Ganesan P, Choi DK (2016) Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy. Int J Nanomed 11:1987\u20132007","journal-title":"Int J Nanomed"},{"issue":"5","key":"3742_CR20","doi-asserted-by":"crossref","first-page":"466","DOI":"10.3390\/cells8050466","volume":"8","author":"P Gentile","year":"2019","unstructured":"Gentile P, Garcovich S (2019) Advances in regenerative stem cell therapy in androgenic alopecia and hair loss: Wnt pathway, growth-factor, and mesenchymal stem cell signaling impact analysis on cell growth and hair follicle development. Cells 8(5):466","journal-title":"Cells"},{"key":"3742_CR21","volume":"15","author":"L Guo","year":"2021","unstructured":"Guo L, Cao W, Niu Y, He S, Chai R, Yang J (2021) Autophagy regulates the survival of hair cells and spiral ganglion neurons in cases of noise, ototoxic drug, and age-induced sensorineural hearing loss. Front Cell Neurosci 15:760422","journal-title":"Front Cell Neurosci"},{"key":"3742_CR22","volume":"46","author":"Y Hu","year":"2022","unstructured":"Hu Y, Li R, Jin J, Wang Y, Ma R (2022) Quercetin improves pancreatic cancer chemo-sensitivity by regulating oxidative-inflammatory networks. J Food Biochem 46:e14453","journal-title":"J Food Biochem"},{"issue":"17","key":"3742_CR23","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.3390\/molecules25174004","volume":"25","author":"J Kim","year":"2020","unstructured":"Kim J, Kim SR, Choi YH, Shin JY, Kim CD, Kang NG, Park BC, Lee S (2020) Quercitrin stimulates hair growth with enhanced expression of growth factors via activation of MAPK\/CREB signaling pathway. Molecules 25(17):4004","journal-title":"Molecules"},{"issue":"4","key":"3742_CR24","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.3390\/ijms24043123","volume":"24","author":"F Li","year":"2023","unstructured":"Li F, Liu H, Wu X, Song Z, Tang H, Gong M, Liu L, Li F (2023a) Tetrathiomolybdate decreases the expression of alkaline phosphatase in dermal papilla cells by increasing mitochondrial ROS production. Int J Mol Sci 24(4):3123","journal-title":"Int J Mol Sci"},{"key":"3742_CR25","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1080\/15548627.2022.2127525","volume":"19","author":"J Li","year":"2023","unstructured":"Li J, Liu C, Muller U, Zhao B (2023b) Autophagy proteins are essential for aminoglycoside-induced hearing loss. Autophagy 19:1599\u20131600","journal-title":"Autophagy"},{"key":"3742_CR26","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nrm2239","volume":"8","author":"MC Maiuri","year":"2007","unstructured":"Maiuri MC, Zalckvar E, Kimchi A, Kroemer G (2007) Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 8:741\u2013752","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3742_CR27","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3109\/09546634.2016.1161155","volume":"27","author":"IG Motofei","year":"2016","unstructured":"Motofei IG, Rowland DL, Georgescu SR, Tampa M, Baconi D, Stefanescu E, Baleanu BC, Balalau C, Constantin V, Paunica S (2016) Finasteride adverse effects in subjects with androgenic alopecia: a possible therapeutic approach according to the lateralization process of the brain. J Dermatolog Treat 27:495\u2013497","journal-title":"J Dermatolog Treat"},{"key":"3742_CR28","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1055\/s-0030-1250111","volume":"76","author":"S Prasad","year":"2010","unstructured":"Prasad S, Phromnoi K, Yadav VR, Chaturvedi MM, Aggarwal BB (2010) Targeting inflammatory pathways by flavonoids for prevention and treatment of cancer. Planta Med 76:1044\u20131063","journal-title":"Planta Med"},{"issue":"19","key":"3742_CR29","doi-asserted-by":"crossref","first-page":"6545","DOI":"10.3390\/molecules27196545","volume":"27","author":"W Qi","year":"2022","unstructured":"Qi W, Qi W, Xiong D, Long M (2022) Quercetin: its antioxidant mechanism, antibacterial properties and potential application in prevention and control of toxipathy. Molecules 27(19):6545","journal-title":"Molecules"},{"issue":"13","key":"3742_CR30","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.3390\/ijms20133177","volume":"20","author":"M Reyes-Farias","year":"2019","unstructured":"Reyes-Farias M, Carrasco-Pozo C (2019) The anti-cancer effect of quercetin: molecular implications in cancer metabolism. Int J Mol Sci 20(13):3177","journal-title":"Int J Mol Sci"},{"key":"3742_CR31","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s12906-016-1180-3","volume":"16","author":"HS Seo","year":"2016","unstructured":"Seo HS, Lee DJ, Chung JH, Lee CH, Kim HR, Kim JE, Kim BJ, Jung MH, Ha KT, Jeong HS (2016) Hominis Placenta facilitates hair re-growth by upregulating cellular proliferation and expression of fibroblast growth factor-7. BMC Complement Altern Med 16:187","journal-title":"BMC Complement Altern Med"},{"key":"3742_CR32","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1089\/adt.2020.993","volume":"18","author":"F Soll","year":"2020","unstructured":"Soll F, Ternent C, Berry IM, Kumari D, Moore TC (2020) Quercetin inhibits proliferation and induces apoptosis of B16 melanoma cells in vitro. Assay Drug Dev Technol 18:261\u2013268","journal-title":"Assay Drug Dev Technol"},{"key":"3742_CR33","first-page":"1001","volume":"15","author":"E Thom","year":"2016","unstructured":"Thom E (2016) Stress and the hair growth cycle: cortisol-induced hair growth disruption. J Drugs Dermatol JDD 15:1001\u20131004","journal-title":"J Drugs Dermatol JDD"},{"issue":"Suppl 1","key":"3742_CR34","first-page":"S9","volume":"43","author":"RM Trueb","year":"2021","unstructured":"Trueb RM (2021) Oxidative stress and its impact on skin, scalp and hair. Int J Cosmet Sci 43(Suppl 1):S9\u2013S13","journal-title":"Int J Cosmet Sci"},{"key":"3742_CR35","doi-asserted-by":"crossref","first-page":"262","DOI":"10.4103\/ijt.ijt_57_18","volume":"10","author":"RM Trueb","year":"2018","unstructured":"Trueb RM, Henry JP, Davis MG, Schwartz JR (2018) Scalp condition impacts hair growth and retention via oxidative stress. Int J Trichology 10:262\u2013270","journal-title":"Int J Trichology"},{"key":"3742_CR36","doi-asserted-by":"crossref","first-page":"42777","DOI":"10.1038\/srep42777","volume":"7","author":"O Veraitch","year":"2017","unstructured":"Veraitch O, Mabuchi Y, Matsuzaki Y, Sasaki T, Okuno H, Tsukashima A, Amagai M, Okano H, Ohyama M (2017) Induction of hair follicle dermal papilla cell properties in human induced pluripotent stem cell-derived multipotent LNGFR(+)THY-1(+) mesenchymal cells. Sci Rep 7:42777","journal-title":"Sci Rep"},{"key":"3742_CR37","volume":"53","author":"J Wu","year":"2020","unstructured":"Wu J, Ye J, Kong W, Zhang S, Zheng Y (2020) Programmed cell death pathways in hearing loss: a review of apoptosis, autophagy and programmed necrosis. Cell Prolif 53:e12915","journal-title":"Cell Prolif"},{"issue":"10","key":"3742_CR38","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.3390\/ijms19103221","volume":"19","author":"Y Zhan","year":"2018","unstructured":"Zhan Y, Wang K, Li Q, Zou Y, Chen B, Gong Q, Ho HI, Yin T, Zhang F, Lu Y et al (2018) The novel autophagy inhibitor Alpha-Hederin promoted paclitaxel cytotoxicity by increasing reactive oxygen species accumulation in non-small cell lung cancer cells. Int J Mol Sci 19(10):3221","journal-title":"Int J Mol Sci"},{"key":"3742_CR39","doi-asserted-by":"crossref","first-page":"2327495","DOI":"10.1080\/0886022X.2024.2327495","volume":"46","author":"L Zhang","year":"2024","unstructured":"Zhang L, Wang X, Chang L, Ren Y, Sui M, Fu Y, Zhang L, Hao L (2024) Quercetin improves diabetic kidney disease by inhibiting ferroptosis and regulating the Nrf2 in streptozotocin-induced diabetic rats. Ren Fail 46:2327495","journal-title":"Ren Fail"},{"key":"3742_CR40","first-page":"81","volume":"24","author":"Z Zhang","year":"2023","unstructured":"Zhang Z, Li W, Chang D, Wei Z, Wang E, Yu J, Xu Y, Que Y, Chen Y, Fan C et al (2023) A combination therapy for androgenic alopecia based on quercetin and zinc\/copper dual-doped mesoporous silica nanocomposite microneedle patch. Bioact Mater 24:81\u201395","journal-title":"Bioact Mater"},{"key":"3742_CR41","volume":"11","author":"L Zhou","year":"2016","unstructured":"Zhou L, Xu M, Yang Y, Yang K, Wickett RR, Andl T, Millar SE, Zhang Y (2016) Activation of beta-catenin signaling in CD133-positive dermal papilla cells drives postnatal hair growth. PLoS ONE 11:e0160425","journal-title":"PLoS ONE"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03742-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-024-03742-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-024-03742-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T06:49:37Z","timestamp":1748587777000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-024-03742-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,24]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["3742"],"URL":"https:\/\/doi.org\/10.1007\/s00210-024-03742-z","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,24]]},"assertion":[{"value":"12 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The ethical considerations governing the animal study protocol were sanctioned by the Committee on the Ethics of Animal Experiments at Guangxi Medical University, under the approval number SYXKGUI 2022-0947. Animal experiments procedure were performed according to ARRIVE guideline.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}