{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:32:41Z","timestamp":1790087561195,"version":"4.0.1"},"reference-count":161,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Science and Technology Research Program of Jilin Provincial Department Education","award":["JJKH20240514KJ"],"award-info":[{"award-number":["JJKH20240514KJ"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s00210-025-03875-9","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T23:11:34Z","timestamp":1741648294000},"page":"9673-9701","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Research progress on the bioactivity of platycodin D from Platycodon grandifloras"],"prefix":"10.1007","volume":"398","author":[{"given":"Ying","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanbo","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinglong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyue","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"issue":"1\u20133","key":"3875_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejphar.2006.03.012","volume":"537","author":"KS Ahn","year":"2006","unstructured":"Ahn KS, Hahn BS, Kwack KB, Lee EB, Kim YS (2006) Platycodin D-induced apoptosis through nuclear factor-\u03baB activation in immortalized keratinocytes. Eur J Pharmacol 537(1\u20133):1\u201311","journal-title":"Eur J Pharmacol"},{"key":"3875_CR2","doi-asserted-by":"publisher","first-page":"106675","DOI":"10.1016\/j.intimp.2020.106675","volume":"85","author":"C Bailly","year":"2020","unstructured":"Bailly C, Vergoten G (2020) Proposed mechanisms for the extracellular release of PD-L1 by the anticancer saponin platycodin D. Int Immunopharmacol 85:106675. https:\/\/doi.org\/10.1016\/j.intimp.2020.106675","journal-title":"Int Immunopharmacol"},{"issue":"13","key":"3875_CR3","doi-asserted-by":"publisher","first-page":"e20","DOI":"10.1128\/MCB.00099-20","volume":"40","author":"L Baird","year":"2020","unstructured":"Baird L, Yamamoto M (2020) The molecular mechanisms regulating the KEAP1-NRF2 pathway. Mol Cell Biol 40(13):e20\u2013e99. https:\/\/doi.org\/10.1128\/MCB.00099-20","journal-title":"Mol Cell Biol"},{"issue":"1","key":"3875_CR4","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s12185-014-1605-z","volume":"100","author":"R Bissinger","year":"2014","unstructured":"Bissinger R, Modicano P, Alzoubi K, Honisch S, Faggio C, Abed M et al (2014) Effect of saponin on erythrocytes. Int J Hematol 100(1):51\u201359","journal-title":"Int J Hematol"},{"issue":"2019","key":"3875_CR5","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.2147\/IJN.S188495","volume":"14","author":"R Cea-Diez","year":"2019","unstructured":"Cea-Diez R, Martin-Moreno A, Mata FJDL, G\u00f3mez-Ramirez R, Muoz-Fern\u00e1ndez MN (2019) G1\u2013S4 or G2\u2013S16 carbosilan dendrimer in combination with Platycodin D as a promising vaginal microbicide candidate with contraceptive activity. Int J Nanomed 14(2019):2371\u20132381","journal-title":"Int J Nanomed"},{"issue":"47","key":"3875_CR6","doi-asserted-by":"publisher","first-page":"17756","DOI":"10.3748\/wjg.v20.i47.17756","volume":"20","author":"E Ceni","year":"2014","unstructured":"Ceni E, Mello T, Galli A (2014) Pathogenesis of alcoholic liver disease: role of oxidative metabolism. World J Gastroenterol Wjg 20(47):17756\u201317772. https:\/\/doi.org\/10.3748\/wjg.v20.i47.17756","journal-title":"World J Gastroenterol Wjg"},{"issue":"6","key":"3875_CR7","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1007\/s12272-016-0752-6","volume":"39","author":"Q Chen","year":"2016","unstructured":"Chen Q, Yang WW, Shen P, Cao QR, Lee BJ, Cui JH (2016) pH-dependent release of platycodin mitigates its gastrointestinal mucosa irritation after oral administration in rats. Arch Pharm Res 39(6):811\u2013824","journal-title":"Arch Pharm Res"},{"issue":"2022","key":"3875_CR8","doi-asserted-by":"publisher","first-page":"1045375","DOI":"10.3389\/fphar.2022.1045375","volume":"13","author":"S Chen","year":"2022","unstructured":"Chen S, Wang Q, Ming S, Zheng H, Hua B, Yang H (2022) Platycodin D induces apoptosis through JNK1\/AP-1\/PUMA pathway in non-small cell lung cancer cells: a new mechanism for an old compound. Front Pharmacol 13(2022):1045375. https:\/\/doi.org\/10.3389\/fphar.2022.1045375","journal-title":"Front Pharmacol"},{"issue":"2018","key":"3875_CR9","first-page":"867","volume":"107","author":"F Cheng-lin","year":"2018","unstructured":"Cheng-lin F, Liu Y, Leng J, Zhang J, He Y-F, Chen C et al (2018) Platycodin D protects acetaminophen-induced hepatotoxicity by inhibiting hepatocyte MAPK pathway and apoptosis in C57BL\/6J mice. Biomed Pharmacother Biomed Pharmacother 107(2018):867\u2013877","journal-title":"Biomed Pharmacother Biomed Pharmacother"},{"key":"3875_CR10","doi-asserted-by":"publisher","first-page":"7918034","DOI":"10.1155\/2018\/7918034","volume":"1","author":"SY Cho","year":"2018","unstructured":"Cho SY, Song CH, Lee JE, Choi SH, Ku SK, Park SJ (2018) (2018) Effects of platycodin D on reflux esophagitis due to modulation of antioxidant defense systems. Evid-Based Compl Altern Med Ecam 1:7918034","journal-title":"Evid-Based Compl Altern Med Ecam"},{"issue":"6","key":"3875_CR11","doi-asserted-by":"publisher","first-page":"519","DOI":"10.4149\/gpb_2020030","volume":"39","author":"YH Choi","year":"2020","unstructured":"Choi YH (2020) Activation of the Nrf2\/HO-1 signaling pathway contributes to the protective effects of platycodin D against oxidative stress-induced DNA damage and apoptosis in C2C12 myoblasts. Gen Physiol Biophys 39(6):519\u2013530","journal-title":"Gen Physiol Biophys"},{"issue":"11","key":"3875_CR12","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1021\/np100496p","volume":"73","author":"Y Choi","year":"2010","unstructured":"Choi Y, Yoo D, Cha M, Choi C, Kim Y, Choi S et al (2010) Antiproliferative effects of saponins from the roots of Platycodon grandiflorum on cultured human tumor cells. J Nat Prod 73(11):1863\u20131867","journal-title":"J Nat Prod"},{"issue":"3","key":"3875_CR13","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.cbi.2013.07.002","volume":"205","author":"J Chun","year":"2013","unstructured":"Chun J, Kim YS (2013) Platycodin D inhibits migration, invasion, and growth of MDA-MB-231 human breast cancer cells via suppression of EGFR-mediated Akt and MAPK pathways. Chemico-Biol Interact 205(3):212\u2013221. https:\/\/doi.org\/10.1016\/j.cbi.2013.07.002","journal-title":"Chemico-Biol Interact"},{"issue":"2","key":"3875_CR14","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1002\/jcb.24386","volume":"114","author":"J Chun","year":"2013","unstructured":"Chun J, Joo EJ, Kang M, Kim YS (2013) Platycodin D induces anoikis and caspase-mediated apoptosis via p38 MAPK in AGS human gastric cancer cells. J Cell Biochem 114(2):456\u2013470","journal-title":"J Cell Biochem"},{"issue":"11","key":"3875_CR15","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1248\/bpb.31.2114","volume":"31","author":"JW Chung","year":"2008","unstructured":"Chung JW, Noh EJ, Zhao HL, Sim J, Ha YW, Shin EM et al (2008) Anti-inflammatory activity of prosapogenin methyl ester of platycodin D via nuclear factor-kappaB pathway inhibition. Biol Pharm Bullet 31(11):2114\u20132120. https:\/\/doi.org\/10.1248\/bpb.31.2114","journal-title":"Biol Pharm Bullet"},{"key":"3875_CR16","doi-asserted-by":"publisher","first-page":"1573578177","DOI":"10.1177\/15347354241263041","volume":"23","author":"M Feng","year":"2024","unstructured":"Feng M, Wang XJ, Liu Y, Zhang W, Wang Y, Zhang C et al (2024) Transcriptomics reveals the mechanism of platycodin D targeting TGF\u03b2for anti-lung cancer activity. Integr Cancer Ther 23:1573578177. https:\/\/doi.org\/10.1177\/15347354241263041","journal-title":"Integr Cancer Ther"},{"issue":"2","key":"3875_CR17","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021108690","volume":"41","author":"H Flores Romero","year":"2022","unstructured":"Flores Romero H, Hohorst L, John M, Albert MC, King LE, Beckmann L et al (2022) BCL-2-family protein tBID can act as a BAX-like effector of apoptosis. Embo J 41(2):e108690. https:\/\/doi.org\/10.15252\/embj.2021108690","journal-title":"Embo J"},{"issue":"4","key":"3875_CR18","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1248\/cpb.54.557","volume":"54","author":"W Fu","year":"2006","unstructured":"Fu W, Shimizu N, Dou D, Takeda T, Fu R, Pei Y et al (2006) Five new triterpenoid saponins from the roots of platycodon grandiflorum. Chem Pharm Bullet 54(4):557\u2013560. https:\/\/doi.org\/10.1248\/cpb.54.557","journal-title":"Chem Pharm Bullet"},{"issue":"9","key":"3875_CR19","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1248\/cpb.54.1285","volume":"54","author":"W Fu","year":"2006","unstructured":"Fu W, Shimizu N, Takeda T, Dou D, Chen B, Pei Y et al (2006) New A-ring lactone triterpenoid saponins from the roots of Platycodon grandiflorum. Chem Pharm Bullet 54(9):1285\u20131287. https:\/\/doi.org\/10.1248\/cpb.54.1285","journal-title":"Chem Pharm Bullet"},{"issue":"6","key":"3875_CR20","doi-asserted-by":"publisher","first-page":"4371","DOI":"10.3390\/molecules16064371","volume":"16","author":"W Fu","year":"2011","unstructured":"Fu W, Fu J, Zhang W, Sun L, Pei Y, Liu P (2011) Platycoside O, a new triterpenoid saponin from the roots of Platycodon grandiflorum. Molecules (Basel, Switzerland) 16(6):4371\u20134378. https:\/\/doi.org\/10.3390\/molecules16064371","journal-title":"Molecules (Basel, Switzerland)"},{"issue":"2018","key":"3875_CR21","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.3389\/fimmu.2017.01929","volume":"8","author":"Y Fu","year":"2018","unstructured":"Fu Y, Xin Z, Liu B, Wang J, Wang J, Zhang X et al (2018) Platycodin D inhibits inflammatory response in LPS-stimulated primary rat microglia cells through activating LXR\u03b1-ABCA1 signaling pathway. Front Immunol 8(2018):1929. https:\/\/doi.org\/10.3389\/fimmu.2017.01929","journal-title":"Front Immunol"},{"issue":"14","key":"3875_CR22","doi-asserted-by":"publisher","first-page":"7544","DOI":"10.3390\/ijms25147544","volume":"25","author":"J Fujii","year":"2024","unstructured":"Fujii J, Imai H (2024) Oxidative metabolism as a cause of lipid peroxidation in the execution of ferroptosis. Int J Mol Sci 25(14):7544. https:\/\/doi.org\/10.3390\/ijms25147544","journal-title":"Int J Mol Sci"},{"issue":"1","key":"3875_CR23","first-page":"1","volume":"71","author":"EO Fukushima","year":"2016","unstructured":"Fukushima EO (2016) Structure and hemolytic activity relationships of triterpenoid saponins and sapogenins. J Nat Med 71(1):1\u20139","journal-title":"J Nat Med"},{"key":"3875_CR24","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.semcdb.2015.01.006","volume":"39","author":"S Fulda","year":"2015","unstructured":"Fulda S (2015) Targeting extrinsic apoptosis in cancer: challenges and opportunities. Semin Cell Dev Biol 39:20\u201325. https:\/\/doi.org\/10.1016\/j.semcdb.2015.01.006","journal-title":"Semin Cell Dev Biol"},{"key":"3875_CR25","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.intimp.2017.03.009","volume":"47","author":"W Gao","year":"2017","unstructured":"Gao W, Guo Y, Yang H (2017) Platycodin D protects against cigarette smoke-induced lung inflammation in mice. Int Immunopharmacol 47:53\u201358. https:\/\/doi.org\/10.1016\/j.intimp.2017.03.009","journal-title":"Int Immunopharmacol"},{"issue":"10","key":"3875_CR26","doi-asserted-by":"publisher","first-page":"2668","DOI":"10.3390\/biomedicines10102668","volume":"10","author":"S Ghareghomi","year":"2022","unstructured":"Ghareghomi S, Habibi-Rezaei M, Arese M, Saso L, Moosavi-Movahedi AA (2022) Nrf2 Modulation in breast cancer. Biomedicines 10(10):2668. https:\/\/doi.org\/10.3390\/biomedicines10102668","journal-title":"Biomedicines"},{"issue":"9","key":"3875_CR27","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1038\/s41556-024-01429-4","volume":"26","author":"HL Glover","year":"2024","unstructured":"Glover HL, Schreiner A, Dewson G, Tait SWG (2024) Mitochondria and cell death. Nat Cell Biol 26(9):1434\u20131446. https:\/\/doi.org\/10.1038\/s41556-024-01429-4","journal-title":"Nat Cell Biol"},{"key":"3875_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111676","volume":"141","author":"R Guo","year":"2021","unstructured":"Guo R, Zhao M, Liu H, Su R, Mao Q, Gong L et al (2021) Uncovering the pharmacological mechanisms of Xijiao Dihuang decoction combined with Yinqiao powder in treating influenza viral pneumonia by an integrative pharmacology strategy. Biomed Pharmacother 141:111676. https:\/\/doi.org\/10.1016\/j.biopha.2021.111676","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"3875_CR29","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.jpba.2009.08.002","volume":"51","author":"YW Ha","year":"2010","unstructured":"Ha YW, Na YC, Ha IJ, Kim DH, Kim YS (2010) Liquid chromatography\/mass spectrometry-based structural analysis of new platycoside metabolites transformed by human intestinal bacteria. J Pharm Biomed Anal 51(1):202\u2013209","journal-title":"J Pharm Biomed Anal"},{"issue":"11","key":"3875_CR30","doi-asserted-by":"publisher","first-page":"513","DOI":"10.3390\/antiox8110513","volume":"8","author":"S Habtemariam","year":"2019","unstructured":"Habtemariam S (2019) Modulation of reactive oxygen species in health and disease. Antioxidants 8(11):513","journal-title":"Antioxidants"},{"issue":"8","key":"3875_CR31","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1016\/j.tet.2004.12.032","volume":"61","author":"Z He","year":"2005","unstructured":"He Z, Qiao C, Han Q, Wang Y, Ye W, Xu H (2005) New triterpenoid saponins from the roots of Platycodon grandiflorum. Tetrahedron 61(8):2211\u20132215. https:\/\/doi.org\/10.1016\/j.tet.2004.12.032","journal-title":"Tetrahedron"},{"issue":"3","key":"3875_CR32","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1194\/jlr.P040501","volume":"55","author":"M Herman-Edelstein","year":"2014","unstructured":"Herman-Edelstein M, Scherzer P, Tobar A, Levi M, Gafter U (2014) Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy. J Lipid Res 55(3):561\u2013572","journal-title":"J Lipid Res"},{"issue":"2","key":"3875_CR33","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","volume":"181","author":"M Hoffmann","year":"2020","unstructured":"Hoffmann M, Kleine-Weber H, Schroeder S, Kr\u00fcger N, Herrler T, Erichsen S et al (2020) SARS-CoV-2 Cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease Inhibitor. Cell 181(2):271\u2013280. https:\/\/doi.org\/10.1016\/j.cell.2020.02.052","journal-title":"Cell"},{"issue":"19","key":"3875_CR34","doi-asserted-by":"publisher","first-page":"4848","DOI":"10.1016\/j.cell.2021.08.017","volume":"184","author":"EC Holmes","year":"2021","unstructured":"Holmes EC, Goldstein SA, Rasmussen AL, Robertson DL, Crits-Christoph A, Wertheim JO et al (2021) The origins of SARS-CoV-2: a critical review. Cell 184(19):4848\u20134856. https:\/\/doi.org\/10.1016\/j.cell.2021.08.017","journal-title":"Cell"},{"key":"3875_CR35","doi-asserted-by":"publisher","first-page":"153442","DOI":"10.1016\/j.phymed.2020.153442","volume":"82","author":"W Hsu","year":"2021","unstructured":"Hsu W, Ramesh S, Shibu MA, Chen M, Wang T, Day CH et al (2021) Platycodin D reverses histone deacetylase inhibitor resistance in hepatocellular carcinoma cells by repressing ERK1\/2-mediated cofilin-1 phosphorylation. Phytomedicine (Stuttgart) 82:153442. https:\/\/doi.org\/10.1016\/j.phymed.2020.153442","journal-title":"Phytomedicine (Stuttgart)"},{"issue":"2","key":"3875_CR36","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.taap.2013.01.001","volume":"267","author":"YP Hwang","year":"2013","unstructured":"Hwang YP, Choi JH, Kim HG, Khanal T, Song GY, Nam MS et al (2013) Saponins, especially platycodin D, from Platycodon grandiflorum modulate hepatic lipogenesis in high-fat diet-fed rats and high glucose-exposed HepG2 cells. Toxicol Appl Pharmacol 267(2):174\u2013183","journal-title":"Toxicol Appl Pharmacol"},{"issue":"12","key":"3875_CR37","doi-asserted-by":"publisher","first-page":"2793","DOI":"10.3987\/COM-10-12058","volume":"81","author":"Y Ida","year":"2010","unstructured":"Ida Y, Fukumura M, Iwasaki D, Hirai Y, Hori Y, Toriizuka K et al (2010) Eight new oleanane-type triterpenoid saponins from platycodon root. Heterocycles 81(12):2793","journal-title":"Heterocycles"},{"issue":"4","key":"3875_CR38","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.ajme.2017.09.001","volume":"54","author":"OM Ighodaro","year":"2018","unstructured":"Ighodaro OM, Akinloye OA (2018) First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): their fundamental role in the entire antioxidant defence grid. Alexandria J Med 54(4):287\u2013293. https:\/\/doi.org\/10.1016\/j.ajme.2017.09.001","journal-title":"Alexandria J Med"},{"issue":"3\u20134","key":"3875_CR39","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.mad.2013.02.008","volume":"134","author":"KD Jacob","year":"2013","unstructured":"Jacob KD, Noren Hooten N, Trzeciak AR, Evans MK (2013) Markers of oxidant stress that are clinically relevant in aging and age-related disease. Mech Ageing Dev 134(3\u20134):139\u2013157","journal-title":"Mech Ageing Dev"},{"issue":"2","key":"3875_CR40","doi-asserted-by":"publisher","first-page":"e297512","DOI":"10.1371\/journal.pone.0297512","volume":"19","author":"A Jang","year":"2024","unstructured":"Jang A, Kim M, Rodin W, Nam YS, Yoo TY, Park WJ (2024) In vitro immune-enhancing effects of Platycodon grandiflorum combined with Salvia plebeian via MAPK and NF-[kappa]B signaling in RAW264.7 cells. Plos One 19(2):e297512. https:\/\/doi.org\/10.1371\/journal.pone.0297512","journal-title":"Plos One"},{"issue":"2","key":"3875_CR41","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1080\/19768354.2019.1588163","volume":"23","author":"D Jeon","year":"2019","unstructured":"Jeon D, Kim S, Kim HS (2019) Platycodin D, a bioactive component of Platycodon grandiflorum, induces cancer cell death associated with extreme vacuolation. Animal Cells Syst 23(2):118\u2013127. https:\/\/doi.org\/10.1080\/19768354.2019.1588163","journal-title":"Animal Cells Syst"},{"issue":"1\u20132","key":"3875_CR42","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/jssc.201300918","volume":"37","author":"EK Jeong","year":"2014","unstructured":"Jeong EK, Ha IJ, Kim YS, Na YC (2014) Glycosylated platycosides: identification by enzymatic hydrolysis and structural determination by LC\u2013MS\/MS. J Separ Sci 37(1\u20132):61\u201368","journal-title":"J Separ Sci"},{"issue":"45","key":"3875_CR43","doi-asserted-by":"publisher","first-page":"80093","DOI":"10.18632\/oncotarget.20278","volume":"8","author":"Y Jiao","year":"2017","unstructured":"Jiao Y, Wang Y, Guo S, Wang G (2017) Glutathione peroxidases as oncotargets. Oncotarget 8(45):80093\u201380102. https:\/\/doi.org\/10.18632\/oncotarget.20278","journal-title":"Glutathione peroxidases as oncotargets. Oncotarget"},{"issue":"4","key":"3875_CR44","doi-asserted-by":"publisher","first-page":"372","DOI":"10.3390\/v12040372","volume":"12","author":"Y Jin","year":"2020","unstructured":"Jin Y, Yang H, Ji W, Wu W, Duan G (2020) Virology, epidemiology, pathogenesis, and control of COVID-19. Viruses-Basel 12(4):372","journal-title":"Viruses-Basel"},{"key":"3875_CR45","volume":"2013","author":"K Jong-Woo","year":"2013","unstructured":"Jong-Woo K, Jin PS, Hwan LJ, Won YJ, Cheul SJ, Wook LS et al (2013) (2013) Triterpenoid saponins isolated from Platycodon grandiflorum inhibit hepatitis C virus replication. Evidence-Based Compl Altern Med 2013:560417","journal-title":"Evidence-Based Compl Altern Med"},{"issue":"6","key":"3875_CR46","doi-asserted-by":"publisher","first-page":"685","DOI":"10.4162\/nrp.2022.16.6.685","volume":"16","author":"JI Jung","year":"2022","unstructured":"Jung JI, Lee HS, Kim SM, Kim S, Lim J, Woo M et al (2022) Immunostimulatory activity of hydrolyzed and fermented Platycodon grandiflorum extract occurs via the MAPK and NF-\u03baB signaling pathway in RAW 264.7 cells. Nutr Res Practice 16(6):685\u2013699. https:\/\/doi.org\/10.4162\/nrp.2022.16.6.685","journal-title":"Nutr Res Practice"},{"issue":"10","key":"3875_CR47","doi-asserted-by":"publisher","first-page":"6425","DOI":"10.1002\/fsn3.3585","volume":"11","author":"J Jung","year":"2023","unstructured":"Jung J, Cho YJ, Jeong M, Lee SS, Kim JH, Kim JE et al (2023) Optimization of extraction condition for platycodin D from Platycodon Grandiflorum root and verification of its biological activity. Food Sci Nutr 11(10):6425\u20136434. https:\/\/doi.org\/10.1002\/fsn3.3585","journal-title":"Food Sci Nutr"},{"issue":"4","key":"3875_CR48","doi-asserted-by":"publisher","first-page":"167378","DOI":"10.1016\/j.jmb.2021.167378","volume":"434","author":"N Ketelut-Carneiro","year":"2022","unstructured":"Ketelut-Carneiro N, Fitzgerald KA (2022) Apoptosis, pyroptosis, and necroptosis\u2014oh my! The many ways a cell can die. J Mol Biol 434(4):167378. https:\/\/doi.org\/10.1016\/j.jmb.2021.167378","journal-title":"J Mol Biol"},{"issue":"7","key":"3875_CR49","doi-asserted-by":"publisher","first-page":"10074","DOI":"10.3390\/molecules190710074","volume":"19","author":"YS Keum","year":"2014","unstructured":"Keum YS, Choi B (2014) Molecular and chemical regulation of the Keap1-Nrf2 signaling pathway. Molecules 19(7):10074","journal-title":"Molecules"},{"issue":"12","key":"3875_CR50","doi-asserted-by":"publisher","first-page":"2674","DOI":"10.1002\/ijc.23442","volume":"122","author":"MO Kim","year":"2008","unstructured":"Kim MO, Moon DO, Choi YH, Lee JD, Kim ND, Kim GY (2008) Platycodin D induces mitotic arrest in vitro, leading to endoreduplication, inhibition of proliferation and apoptosis in leukemia cells. Int J Cancer 122(12):2674\u20132681","journal-title":"Int J Cancer"},{"issue":"1","key":"3875_CR51","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.canlet.2007.11.010","volume":"261","author":"M Kim","year":"2008","unstructured":"Kim M, Moon D, Choi YH, Shin DY, Kang HS, Choi BT et al (2008) Platycodin D induces apoptosis and decreases telomerase activity in human leukemia cells. Cancer Lett 261(1):98\u2013107. https:\/\/doi.org\/10.1016\/j.canlet.2007.11.010","journal-title":"Cancer Lett"},{"issue":"3","key":"3875_CR52","doi-asserted-by":"publisher","first-page":"187","DOI":"10.3177\/jnsv.58.187","volume":"58","author":"TW Kim","year":"2012","unstructured":"Kim TW, Lim JH, Song IB, Park SJ, Yang JW, Shin JC et al (2012) Hepatoprotective and anti-hepatitis C viral activity of Platycodon grandiflorum extract on carbon tetrachloride-induced acute hepatic injury in mice. J Nutr Sci Vitaminol 58(3):187\u2013194","journal-title":"J Nutr Sci Vitaminol"},{"key":"3875_CR53","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.fct.2012.10.017","volume":"51","author":"T Kim","year":"2013","unstructured":"Kim T, Lee H, Song I, Lim J, Cho E, Son H et al (2013) Platycodin D attenuates bile duct ligation-induced hepatic injury and fibrosis in mice. Food Chem Toxicol 51:364\u2013369. https:\/\/doi.org\/10.1016\/j.fct.2012.10.017","journal-title":"Food Chem Toxicol"},{"issue":"35","key":"3875_CR54","doi-asserted-by":"publisher","first-page":"7721","DOI":"10.1021\/acs.jafc.5b01908","volume":"63","author":"HL Kim","year":"2015","unstructured":"Kim HL, Park J, Park H, Jung Y, Youn DH, Kang JW et al (2015) Platycodon grandiflorum A. de candolle ethanolic extract inhibits adipogenic regulators in 3T3-L1 cells and induces mitochondrial biogenesis in primary brown preadipocytes. J Agric Food Chem 63(35):7721\u20137730","journal-title":"J Agric Food Chem"},{"issue":"2019","key":"3875_CR55","first-page":"254","volume":"52","author":"H-L Kim","year":"2019","unstructured":"Kim H-L, Park J, Jung Y et al (2019) Platycodin D, a novel activator of AMP-activated protein kinase, attenuates obesity in db\/db mice via regulation of adipogenesis and thermogenesis. Phytomed Int J Phytother Phytopharmacol 52(2019):254\u2013263","journal-title":"Phytomed Int J Phytother Phytopharmacol"},{"issue":"5","key":"3875_CR56","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1038\/s12276-021-00624-9","volume":"53","author":"TY Kim","year":"2021","unstructured":"Kim TY, Jeon S, Jang Y, Gotina L, Won J, Ju YH et al (2021) Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion. Exp Mol Med 53(5):956\u2013972. https:\/\/doi.org\/10.1038\/s12276-021-00624-9","journal-title":"Exp Mol Med"},{"issue":"3","key":"3875_CR57","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.3892\/or.2016.4935","volume":"36","author":"Y Kong","year":"2016","unstructured":"Kong Y, Lu ZL, Wang JJ, Zhou R, Guo J, Liu J et al (2016) Platycodin D, a metabolite of Platycodin grandiflorum, inhibits highly metastatic MDA-MB-231 breast cancer growth invitro and in vivo by targeting the MDM2 oncogene. Oncol Rep 36(3):1447\u20131456","journal-title":"Oncol Rep"},{"issue":"7","key":"3875_CR58","doi-asserted-by":"publisher","first-page":"e11765","DOI":"10.1371\/journal.pone.0011765","volume":"5","author":"RK Kristiina","year":"2010","unstructured":"Kristiina RK, Jani L, Katariina R, Elina VLK, Sampsa M, Kovanen PT et al (2010) Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation. Plos One 5(7):e11765","journal-title":"Plos One"},{"issue":"1","key":"3875_CR59","doi-asserted-by":"publisher","first-page":"102378","DOI":"10.1016\/j.jceh.2024.102378","volume":"15","author":"A Kumar","year":"2025","unstructured":"Kumar A, Arora A, Sharma P, Jan S, Ara I (2025) Visceral fat and diabetes: associations with liver fibrosis in metabolic dysfunction-associated steatotic liver disease. J Clin Exp Hepatol 15(1):102378","journal-title":"J Clin Exp Hepatol"},{"key":"3875_CR60","doi-asserted-by":"publisher","first-page":"954508","DOI":"10.1155\/2014\/954508","volume":"4","author":"OG Kwon","year":"2014","unstructured":"Kwon OG, Ku SK, An HD, Lee YJ (2014) (2013) The effects of platycodin D, a saponin purified from platycodi radix, on collagen-induced DBA\/1J mouse rheumatoid arthritis. Evid-Based Compl Altern Med 4:954508","journal-title":"Evid-Based Compl Altern Med"},{"issue":"9","key":"3875_CR61","doi-asserted-by":"publisher","first-page":"413","DOI":"10.3390\/antiox8090413","volume":"8","author":"DH Kwon","year":"2019","unstructured":"Kwon DH, Lee H, Park C, Hong SH, Choi YH (2019) Glutathione induced immune-stimulatory activity by promoting M1-like macrophages polarization via potential ROS scavenging capacity. Antioxidants 8(9):413","journal-title":"Antioxidants"},{"issue":"2020","key":"3875_CR62","doi-asserted-by":"publisher","first-page":"127029","DOI":"10.1016\/j.foodchem.2020.127029","volume":"327","author":"Le Le Zhang","year":"2020","unstructured":"Le Zhang Le, Huang MY, Yang Y, Huang MQ, Shi JJ, Zou L et al (2020) Bioactive platycodins from Platycodonis Radix: Phytochemistry, pharmacological activities, toxicology and pharmacokinetics - ScienceDirect. Food Chemistry 327(2020):127029","journal-title":"Food Chemistry"},{"issue":"11\u201312","key":"3875_CR63","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.lfs.2011.07.006","volume":"89","author":"H Lee","year":"2011","unstructured":"Lee H, Bae S, Kim YS, Yoon Y (2011) WNT\/\u03b2-catenin pathway mediates the anti-adipogenic effect of platycodin D, a natural compound found in Platycodon grandiflorum. Life Sci (1973) 89(11\u201312):388\u2013394. https:\/\/doi.org\/10.1016\/j.lfs.2011.07.006","journal-title":"Life Sci (1973)"},{"issue":"14","key":"3875_CR64","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1055\/s-0032-1315147","volume":"78","author":"EJ Lee","year":"2012","unstructured":"Lee EJ, Kang M, Kim YS (2012) Platycodin D Inhibits Lipogenesis through AMPK\u03b1-PPAR\u03b32 in 3T3-L1 Cells and Modulates Fat Accumulation in Obese Mice. Planta Medica 78(14):1536\u20131542. https:\/\/doi.org\/10.1055\/s-0032-1315147","journal-title":"Planta Medica"},{"issue":"5","key":"3875_CR65","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1159\/000430152","volume":"36","author":"SK Lee","year":"2015","unstructured":"Lee SK, Park K, Kim H, Kim KR, Kang EJ, Kim YL et al (2015) Platycodin D blocks breast cancer-induced bone destruction by inhibiting osteoclastogenesis and the growth of breast cancer cells. Cell Physiol Biochem 36(5):1809\u20131820. https:\/\/doi.org\/10.1159\/000430152","journal-title":"Cell Physiol Biochem"},{"issue":"1","key":"3875_CR66","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1002\/1878-0261.12966","volume":"16","author":"SJ Lee","year":"2022","unstructured":"Lee SJ, Choi YJ, Kim HI, Moon HE, Paek SH, Kim TY et al (2022) Platycodin D inhibits autophagy and increases glioblastoma cell death via LDLR upregulation. Mol Oncol 16(1):250\u2013268. https:\/\/doi.org\/10.1002\/1878-0261.12966","journal-title":"Mol Oncol"},{"issue":"12","key":"3875_CR67","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1038\/aps.2015.99","volume":"36","author":"T Li","year":"2015","unstructured":"Li T, Xu X, Tang Z, Wang Y, Leung C, Ma D et al (2015) Platycodin D induces apoptosis and triggers ERK- and JNK-mediated autophagy in human hepatocellular carcinoma BEL-7402 cells. Acta Pharmacologica Sinica 36(12):1503\u20131513","journal-title":"Acta Pharmacologica Sinica"},{"issue":"2015","key":"3875_CR68","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.ejphar.2015.01.003","volume":"749","author":"T Li","year":"2015","unstructured":"Li T, Tang ZH, Xu WS, Wu GS, Wang YF, Chang LL et al (2015) Platycodin D triggers autophagy through activation of extracellular signal-regulated kinase in hepatocellular carcinoma HepG2 cells. Eur J Pharmacol 749(2015):81\u201388. https:\/\/doi.org\/10.1016\/j.ejphar.2015.01.003","journal-title":"Eur J Pharmacol"},{"issue":"5","key":"3875_CR69","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1039\/C5FO00094G","volume":"6","author":"W Li","year":"2015","unstructured":"Li W, Liu Y, Wang Z, Han Y, Tian YH, Zhang GS et al (2015) Platycodin D isolated from the aerial parts of Platycodon grandiflorum protects alcohol-induced liver injury in mice. Food Funct 6(5):1418\u20131427","journal-title":"Food Funct"},{"issue":"3","key":"3875_CR70","doi-asserted-by":"publisher","first-page":"417","DOI":"10.2131\/jts.41.417","volume":"41","author":"W Li","year":"2016","unstructured":"Li W, Tian YH, Liu Y, Wang Z, Tang S, Zhang J et al (2016) Platycodin D exerts anti-tumor efficacy in H22 tumor-bearing mice via improving immune function and inducing apoptosis. J Toxicol Sci 41(3):417\u2013428","journal-title":"J Toxicol Sci"},{"issue":"1","key":"3875_CR71","doi-asserted-by":"publisher","first-page":"37997","DOI":"10.1038\/srep37997","volume":"6","author":"T Li","year":"2016","unstructured":"Li T, Chen X, Chen X, Ma DL, Lu CHLJ (2016) Platycodin D potentiates proliferation inhibition and apoptosis induction upon AKT inhibition via feedback blockade in non-small cell lung cancer cells. Sci Rep 6(1):37997","journal-title":"Sci Rep"},{"issue":"1","key":"3875_CR72","doi-asserted-by":"publisher","first-page":"2205053","DOI":"10.1080\/08916934.2023.2205053","volume":"56","author":"P Li","year":"2023","unstructured":"Li P, Huang Y, Wang J, Zeng J, Li L (2023) Platycodin D relieves rheumatoid arthritis by promoting apoptosis of mitochondria to inhibit activation of hedgehog pathway. Autoimmunity (Chur, Switzerland) 56(1):2205053. https:\/\/doi.org\/10.1080\/08916934.2023.2205053","journal-title":"Autoimmunity (Chur, Switzerland)"},{"key":"3875_CR73","doi-asserted-by":"publisher","first-page":"117215","DOI":"10.1016\/j.biopha.2024.117215","volume":"178","author":"Y Li","year":"2024","unstructured":"Li Y, Xiao P, Sun Y, Li Y, Zhao H, Sun J et al (2024a) Deapioplatycodin D promotes cell senescence induced by P21 through the mediation of incomplete mitophagy via BNIP3L. Biomed Pharmacother 178:117215. https:\/\/doi.org\/10.1016\/j.biopha.2024.117215","journal-title":"Biomed Pharmacother"},{"issue":"2024","key":"3875_CR74","doi-asserted-by":"publisher","first-page":"112782","DOI":"10.1016\/j.intimp.2024.112782","volume":"139","author":"W Li","year":"2024","unstructured":"Li W, Zhang Y, Cao Y, Zhao X, Xie J (2024b) Protective effects and regulatory mechanisms of platycodin D against LPS-induced inflammatory injury in BEAS-2B cells. Int Immunopharmacol 139(2024):112782","journal-title":"Int Immunopharmacol"},{"key":"3875_CR75","doi-asserted-by":"publisher","first-page":"106750","DOI":"10.1016\/j.marenvres.2024.106750","volume":"202","author":"L Li","year":"2024","unstructured":"Li L, Chang J, Xu Z, Chu L, Zhang J, Xing Q et al (2024c) Functional allocation of mitogen-activated protein kinases (MAPKs) unveils thermotolerance in scallop Argopecten irradians irradians. Mar Environ Res 202:106750. https:\/\/doi.org\/10.1016\/j.marenvres.2024.106750","journal-title":"Mar Environ Res"},{"issue":"3","key":"3875_CR76","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1142\/S0192415X18500271","volume":"46","author":"YC Lin","year":"2018","unstructured":"Lin YC, Lin YC, Kuo WW, Shen CY, Cheng YC, Lin YM et al (2018) Platycodin D reverses pathological cardiac hypertrophy and fibrosis in spontaneously hypertensive rats. Am J Chin Med 46(3):1\u201313","journal-title":"Am J Chin Med"},{"issue":"3","key":"3875_CR77","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.chmed.2024.01.005","volume":"16","author":"D Liu","year":"2024","unstructured":"Liu D (2024) Ethnopharmacology, phytochemistry, pharmacology and product application of Platy codon grandiflorum: A review. Chinese Herbal Med 16(3):327\u2013343","journal-title":"Chinese Herbal Med"},{"issue":"5","key":"3875_CR78","doi-asserted-by":"publisher","first-page":"172946","DOI":"10.1016\/j.ejphar.2020.172946","volume":"876","author":"Y Liu","year":"2020","unstructured":"Liu Y, Cong S, Cheng Z, Hu Y, Lei Y, Zhu L et al (2020) Platycodin D alleviates liver fibrosis and activation of hepatic stellate cells by regulating JNK\/c-JUN signal pathway. Eur J Pharmacol 876(5):172946. https:\/\/doi.org\/10.1016\/j.ejphar.2020.172946","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"3875_CR79","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1038\/s41598-021-81263-y","volume":"11","author":"Y Liu","year":"2021","unstructured":"Liu Y, Fan L, Cheng Z, Yu L, Cong S, Hu Y et al (2021) Fecal transplantation alleviates acute liver injury in mice through regulating Treg\/Th17 cytokines balance. Sci Rep 11(1):1611","journal-title":"Sci Rep"},{"key":"3875_CR80","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.exphem.2023.04.002","volume":"123","author":"P Liu","year":"2023","unstructured":"Liu P, Zhao M, Lin Y, Jiang X, Xia T, Li Y et al (2023) Platycodin D induces proliferation inhibition and mitochondrial apoptosis in diffuse large B-cell lymphoma. Exp Hematol 123:46\u201355. https:\/\/doi.org\/10.1016\/j.exphem.2023.04.002","journal-title":"Exp Hematol"},{"issue":"3","key":"3875_CR81","doi-asserted-by":"publisher","first-page":"580","DOI":"10.3390\/foods12030580","volume":"12","author":"Y Liu","year":"2023","unstructured":"Liu Y, Zhang Q, Wang Y, Xu P, Wang L, Liu L et al (2023) Enrichment of wheat bread with Platycodon grandiflorus root (PGR) flour: rheological properties and microstructure of dough and physicochemical characterization of bread. Foods 12(3):580. https:\/\/doi.org\/10.3390\/foods12030580","journal-title":"Foods"},{"issue":"11","key":"3875_CR82","doi-asserted-by":"publisher","first-page":"e82068","DOI":"10.1371\/journal.pone.0082068","volume":"8","author":"Z Lu","year":"2013","unstructured":"Lu Z, Wang L, Zhou R, Qiu Y, Yang L, Zhang C et al (2013) Evaluation of the spermicidal and contraceptive activity of platycodin D, a saponin from Platycodon grandiflorum. Plos One 8(11):e82068","journal-title":"Plos One"},{"key":"3875_CR83","doi-asserted-by":"publisher","first-page":"648985","DOI":"10.3389\/fonc.2021.648985","volume":"11","author":"Z Lu","year":"2021","unstructured":"Lu Z, Song W, Zhang Y, Wu C, Zhu M, Wang H et al (2021) Combined anti-cancer effects of platycodin D and sorafenib on androgen-independent and PTEN-deficient prostate cancer. Front Oncol 11:648985. https:\/\/doi.org\/10.3389\/fonc.2021.648985","journal-title":"Front Oncol"},{"issue":"22","key":"3875_CR84","doi-asserted-by":"publisher","first-page":"12516","DOI":"10.1021\/acs.jafc.3c08490","volume":"72","author":"Y Lu","year":"2024","unstructured":"Lu Y, Xie L, Qi M, Ren S, Wang Y, Hu J et al (2024) Platycodin D ameliorates cognitive impairment in type 2 diabetes mellitus mice via regulating PI3K\/Akt\/GSK3\u03b2 signaling pathway. J Agric Food Chem 72(22):12516\u201312528. https:\/\/doi.org\/10.1021\/acs.jafc.3c08490","journal-title":"J Agric Food Chem"},{"issue":"1","key":"3875_CR85","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.taap.2014.09.009","volume":"281","author":"X Luan","year":"2014","unstructured":"Luan X, Gao Y, Guan Y, Xu J, Lu Q, Zhao M et al (2014) Platycodin D inhibits tumor growth by antiangiogenic activity via blocking VEGFR2-mediated signaling pathway. Toxicol Appl Pharmacol 281(1):118\u2013124. https:\/\/doi.org\/10.1016\/j.taap.2014.09.009","journal-title":"Toxicol Appl Pharmacol"},{"issue":"18","key":"3875_CR86","doi-asserted-by":"publisher","first-page":"10814","DOI":"10.1039\/d0ra09443a","volume":"11","author":"X Ma","year":"2021","unstructured":"Ma X, Shao S, Xiao F, Zhang H, Zhang R, Wang M et al (2021) Platycodon grandiflorum extract: chemical composition and whitening, antioxidant, and anti-inflammatory effects. Rsc Advances 11(18):10814\u201310826. https:\/\/doi.org\/10.1039\/d0ra09443a","journal-title":"Rsc Advances"},{"issue":"6378","key":"3875_CR87","doi-asserted-by":"publisher","first-page":"eaao6047","DOI":"10.1126\/science.aao6047","volume":"359","author":"K McArthur","year":"2018","unstructured":"McArthur K, Whitehead LW, Heddleston JM, Li L, Padman BS, Oorschot V et al (2018) BAK\/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis. Sci Am Assoc Adv Sci 359(6378):eaao6047. https:\/\/doi.org\/10.1126\/science.aao6047","journal-title":"Sci Am Assoc Adv Sci"},{"issue":"5","key":"3875_CR88","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.dmpk.2017.05.005","volume":"32","author":"K Mihwa","year":"2017","unstructured":"Mihwa K, Ji H-K, Hyeon SG et al (2017) Involvement of intestinal efflux and metabolic instability in?the?pharmacokinetics of platycodin D in rats. Drug Metab Pharmacokin 32(5):248\u2013254","journal-title":"Drug Metab Pharmacokin"},{"issue":"5","key":"3875_CR89","doi-asserted-by":"publisher","first-page":"132","DOI":"10.3390\/antiox8050132","volume":"8","author":"Y Miyata","year":"2019","unstructured":"Miyata Y, Matsuo T, Mitsunari K, Asai A, Sakai H (2019) A review of oxidative stress and urinary dysfunction caused by bladder outlet obstruction and treatments using antioxidants. Antioxidants 8(5):132","journal-title":"Antioxidants"},{"issue":"9","key":"3875_CR90","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.7150\/ijbs.11595","volume":"11","author":"K Muhammad","year":"2015","unstructured":"Muhammad K, Amara M, Iqbal QJ, Tonghui M (2015) Targeting apoptosis and multiple signaling pathways with icariside II in cancer cells. Int J Biol Sci 11(9):1100\u20131112","journal-title":"Int J Biol Sci"},{"issue":"1\u20132","key":"3875_CR91","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.chroma.2007.11.085","volume":"1189","author":"YC Na","year":"2008","unstructured":"Na YC, Ha YW, Kim YS, Kim KJ (2008) Structural analysis of platycosides in platycodi radix by liquid chromatography\/electrospray ionization-tandem mass spectrometry. J Chromatograph A 1189(1\u20132):467\u2013475","journal-title":"J Chromatograph A"},{"issue":"2","key":"3875_CR92","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1586\/egh.11.6","volume":"5","author":"AC Naim","year":"2011","unstructured":"Naim AC, Carter-Kent AE et al (2011) Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications. Exp Rev Gastroenterol Hepatol 5(2):201\u2013212","journal-title":"Exp Rev Gastroenterol Hepatol"},{"key":"3875_CR93","doi-asserted-by":"publisher","first-page":"117090","DOI":"10.1016\/j.biopha.2024.117090","volume":"177","author":"Y Nam","year":"2024","unstructured":"Nam Y, Ji Y, Shin SJ, Park HH, Yeon S, Kim S et al (2024) Platycodon grandiflorum root extract inhibits A\u03b2 deposition by breaking the vicious circle linking oxidative stress and neuroinflammation in Alzheimer\u2019s disease. Biomed Pharmacother 177:117090. https:\/\/doi.org\/10.1016\/j.biopha.2024.117090","journal-title":"Biomed Pharmacother"},{"issue":"9","key":"3875_CR94","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1016\/j.bbamcr.2014.05.003","volume":"1843","author":"A Namani","year":"2014","unstructured":"Namani A, Li Y, Wan XJ, Tang X (2014) Modulation of NRF2 signaling pathway by nuclear receptors: implications for cancer\u2014ScienceDirect. Biochimica Et Biophysica Acta Bba - Molecular Cell Research 1843(9):1875\u20131885","journal-title":"Biochimica Et Biophysica Acta Bba - Molecular Cell Research"},{"issue":"10","key":"3875_CR95","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1016\/j.jacc.2018.12.055","volume":"73","author":"UI Onat","year":"2019","unstructured":"Onat UI, Yildirim AD, Tufanli Z, Imen I, Kocat\u00fcrk B, Veli Z et al (2019) Intercepting the lipid-induced integrated stress response reduces atherosclerosis. Js Am College Cardiol 73(10):1149\u20131169","journal-title":"Js Am College Cardiol"},{"key":"3875_CR96","doi-asserted-by":"publisher","first-page":"478653","DOI":"10.1155\/2014\/478653","volume":"2","author":"JC Park","year":"2014","unstructured":"Park JC, Lee YJ, Choi HY, Shin YK, Ku SK (2014) (2014) In vivo and in vitro antitumor effects of platycodin d, a saponin purified from platycodi radix on the H520 lung cancer cell, 2014 (2014-11-13). Evid Based Compl Altern Med 2:478653","journal-title":"Evid Based Compl Altern Med"},{"issue":"3","key":"3875_CR97","doi-asserted-by":"publisher","first-page":"330","DOI":"10.4162\/nrp.2022.16.3.330","volume":"16","author":"C Park","year":"2022","unstructured":"Park C, Choi EO, Hwangbo H, Lee H, Jeong J, Han MH et al (2022) Induction of apoptotic cell death in human bladder cancer cells by ethanol extract of Zanthoxylum schinifolium leaf, through ROS-dependent inactivation of the PI3K\/Akt signaling pathway. Nutr Res Pract 16(3):330\u2013343. https:\/\/doi.org\/10.4162\/nrp.2022.16.3.330","journal-title":"Nutr Res Pract"},{"issue":"5\u20136","key":"3875_CR98","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1159\/000502913","volume":"86","author":"Y Peng","year":"2019","unstructured":"Peng Y, Fan J, Xiong J, Lou Y, Zhu Y (2019) miR-34a enhances the susceptibility of gastric cancer to platycodin D by targeting survivin. Pathobiology (Basel) 86(5\u20136):296\u2013305. https:\/\/doi.org\/10.1159\/000502913","journal-title":"Pathobiology (Basel)"},{"issue":"2","key":"3875_CR99","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1007\/s13277-013-1169-1","volume":"35","author":"H Qin","year":"2014","unstructured":"Qin H, Du X, Zhang Y, Wang R (2014) Platycodin D, a triterpenoid saponin from Platycodon grandiflorum, induces G2\/M arrest and apoptosis in human hepatoma HepG2 cells by modulating the PI3K\/Akt pathway. Tumour Biol J Int Soc Oncodev Biol Med 35(2):1267","journal-title":"Tumour Biol J Int Soc Oncodev Biol Med"},{"issue":"5","key":"3875_CR100","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1080\/10286020.2018.1488835","volume":"21","author":"L Qiu","year":"2019","unstructured":"Qiu L, Xiao Y, Liu Y, Peng L, Liao W, Fu Q (2019) Platycosides P and Q, two new triterpene saponins from Platycodon grandiflorum. J Asian Nat Prod Res 21(5):419\u2013425. https:\/\/doi.org\/10.1080\/10286020.2018.1488835","journal-title":"J Asian Nat Prod Res"},{"key":"3875_CR101","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.intimp.2016.09.025","volume":"40","author":"Y Qu","year":"2016","unstructured":"Qu Y, Zhou L, Wang C (2016) Effects of platycodin D on IL-1\u03b2-induced inflammatory response in human osteoarthritis chondrocytes. Int Immunopharmacol 40:474\u2013479","journal-title":"Int Immunopharmacol"},{"issue":"11","key":"3875_CR102","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1038\/nrm1496","volume":"5","author":"SJ Riedl","year":"2004","unstructured":"Riedl SJ, Shi Y (2004) Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol 5(11):897\u2013907","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"7","key":"3875_CR103","doi-asserted-by":"publisher","first-page":"623","DOI":"10.7150\/jca.11291","volume":"6","author":"Z Ruolin","year":"2015","unstructured":"Ruolin Z, Meijuan C, Zequn J, Fengming Z, Beili X, Xu Z et al (2015) Platycodin-D induced autophagy in non-small cell lung cancer cells via PI3K\/Akt\/mTOR and MAPK Signaling Pathways. J Cancer 6(7):623\u2013631","journal-title":"J Cancer"},{"issue":"44","key":"3875_CR104","doi-asserted-by":"publisher","first-page":"750","DOI":"10.4103\/0973-1296.165576","volume":"11","author":"J Shan","year":"2015","unstructured":"Shan J, Zou J, Xie T, Kang A, Wang S (2015) Pharmacokinetics, intestinal absorption and microbial metabolism of single platycodin D in comparison to Platycodi radix extract. Pharm Mag 11(44):750\u2013755","journal-title":"Pharm Mag"},{"issue":"2024","key":"3875_CR105","doi-asserted-by":"publisher","first-page":"139521","DOI":"10.1016\/j.foodchem.2024.139521","volume":"451","author":"Y Shang","year":"2024","unstructured":"Shang Y, Chen H, Ni Z, Thakur K, Zhang J, Khan MR et al (2024) Platycodon grandiflorum saponins: Ionic liquid-ultrasound-assisted extraction, antioxidant, whitening, and antiaging activity. Food Chem 451(2024):139521. https:\/\/doi.org\/10.1016\/j.foodchem.2024.139521","journal-title":"Food Chem"},{"issue":"8","key":"3875_CR106","doi-asserted-by":"publisher","first-page":"e2000497","DOI":"10.1002\/ardp.202000497","volume":"354","author":"J Shen","year":"2021","unstructured":"Shen J, Zhu Y, Zhou B, Kong L, Jin Y, Zhang D et al (2021) In vitro and in vivo evaluation of a water-in-oil microemulsion of platycodin D. Archiv Der Pharmazie (Weinheim) 354(8):e2000497. https:\/\/doi.org\/10.1002\/ardp.202000497","journal-title":"Archiv Der Pharmazie (Weinheim)"},{"issue":"5","key":"3875_CR107","doi-asserted-by":"publisher","first-page":"116596","DOI":"10.1016\/j.jep.2023.116596","volume":"314","author":"Q Shen","year":"2023","unstructured":"Shen Q, Qi SM, Zhang JT, Li MH, Wang YP, Wang Z et al (2023) Platycodin D inhibits HFD\/STZ-induced diabetic nephropathy via inflammatory and apoptotic signaling pathways in C57BL\/6 mice. J Ethnopharmacol 314(5):116596","journal-title":"J Ethnopharmacol"},{"issue":"9\u201310","key":"3875_CR108","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1159\/000505593","volume":"105","author":"C Shi","year":"2020","unstructured":"Shi C, Li Q, Zhang X (2020) Platycodin D protects human fibroblast cells from premature senescence induced by H2O2 through improving mitochondrial biogenesis. Pharmacology 105(9\u201310):598\u2013608","journal-title":"Pharmacology"},{"issue":"1","key":"3875_CR109","doi-asserted-by":"publisher","first-page":"e14419","DOI":"10.1111\/cbdd.14419","volume":"103","author":"Y Song","year":"2024","unstructured":"Song Y, Lv P, Yu J (2024) Platycodin D inhibits diabetic retinopathy via suppressing TLR4\/MyD88\/NF-B signaling pathway and activating Nrf2\/HO-1 signaling pathway. Chem Biol Drug Des 103(1):e14419. https:\/\/doi.org\/10.1111\/cbdd.14419","journal-title":"Chem Biol Drug Des"},{"issue":"5","key":"3875_CR110","doi-asserted-by":"publisher","first-page":"581","DOI":"10.5021\/ad.2018.30.5.581","volume":"30","author":"Y Suh","year":"2018","unstructured":"Suh Y, Yang JH, Yoon JY, Choi YS (2018) Platycodin D may improve acne and prevent scarring by downregulating SREBP-1 expression via inhibition of IGF-1R\/PI3K\/Akt pathway and modulating inflammation with an increase in collagen. Annals Dermatol 30(5):581\u2013587. https:\/\/doi.org\/10.5021\/ad.2018.30.5.581","journal-title":"Annals Dermatol"},{"issue":"5","key":"3875_CR111","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1080\/10799893.2020.1767135","volume":"40","author":"F Sun","year":"2020","unstructured":"Sun F, Liu F (2020) Platycodin D inhibits MPP+-induced inflammatory response in BV-2 cells through the TLR4\/MyD88\/NF-\u03baB signaling pathway. J Recept Signal Trans 40(5):479\u2013485. https:\/\/doi.org\/10.1080\/10799893.2020.1767135","journal-title":"J Recept Signal Trans"},{"issue":"12","key":"3875_CR112","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1016\/j.intimp.2011.08.018","volume":"11","author":"H Sun","year":"2011","unstructured":"Sun H, Chen L, Wang J, Wang K, Zhou J (2011) Structure\u2013function relationship of the saponins from the roots of Platycodon grandiflorum for hemolytic and adjuvant activity. Int Immunopharmacol 11(12):2047\u20132056","journal-title":"Int Immunopharmacol"},{"issue":"8","key":"3875_CR113","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","volume":"19","author":"KV Swanson","year":"2019","unstructured":"Swanson KV, Deng M, Ting JP (2019) The NLRP3 inflammasome: molecular activation and regulation to therapeutics Nature Reviews. Immunology 19(8):477\u2013489. https:\/\/doi.org\/10.1038\/s41577-019-0165-0","journal-title":"Immunology"},{"issue":"4","key":"3875_CR114","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3390\/antiox8040097","volume":"8","author":"A Todorovi\u0107","year":"2019","unstructured":"Todorovi\u0107 A, Peji\u0107 S, Gavrilovi\u0107 L, Pavlovi\u0107 I, Stojiljkovi\u0107 V, Popovi\u0107 N et al (2019) Expression of antioxidant enzymes in patients with uterine polyp, myoma, hyperplasia, and adenocarcinoma. Antioxidants 8(4):97","journal-title":"Antioxidants"},{"issue":"2","key":"3875_CR115","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.intimp.2015.04.001","volume":"26","author":"C Tong","year":"2015","unstructured":"Tong C, Gao J, Xiang P et al (2015) Protective effect of platycodin D on liver injury in alloxan-induced diabetic mice via regulation of Treg\/Th17 balance. Int Immunopharmacol 26(2):338\u2013348","journal-title":"Int Immunopharmacol"},{"issue":"4","key":"3875_CR116","first-page":"663","volume":"11","author":"G Tossetta","year":"2022","unstructured":"Tossetta G, Fantone S, Montanari E, Marzioni D, Goteri G (2022) Role of NRF2 in ovarian cancer. Antioxidants (Basel, Switzerland) 11(4):663","journal-title":"Antioxidants (Basel, Switzerland)"},{"issue":"8","key":"3875_CR117","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1016\/j.bcp.2007.10.027","volume":"75","author":"S Uwe","year":"2008","unstructured":"Uwe S (2008) Anti-inflammatory interventions of NF-[kappa]B signaling: potential applications and risks. Biochem Pharmacol 75(8):1567\u20131579. https:\/\/doi.org\/10.1016\/j.bcp.2007.10.027","journal-title":"Biochem Pharmacol"},{"key":"3875_CR118","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.coph.2015.05.014","volume":"23","author":"L Vela","year":"2015","unstructured":"Vela L, Marzo I (2015) Bcl-2 family of proteins as drug targets for cancer chemotherapy: the long way of BH3 mimetics from bench to bedside. Curr Opinion Pharmacol 23:74\u201381. https:\/\/doi.org\/10.1016\/j.coph.2015.05.014","journal-title":"Curr Opinion Pharmacol"},{"issue":"9","key":"3875_CR119","doi-asserted-by":"publisher","first-page":"17897","DOI":"10.3390\/ijms140917897","volume":"14","author":"K Venkataraman","year":"2013","unstructured":"Venkataraman K, Khurana S, Tai T (2013) Oxidative stress in aging-matters of the heart and mind. Int J Mol Sci 14(9):17897\u201317925","journal-title":"Int J Mol Sci"},{"issue":"9","key":"3875_CR120","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.3390\/plants9091240","volume":"9","author":"LB Vinh","year":"2020","unstructured":"Vinh LB, Heo M, Phong NV, Ali I, Koh YS, Kim YH et al (2020) Bioactive compounds from Polygala tenuifolia and their inhibitory effects on lipopolysaccharide-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells. Plants-Basel 9(9):1240. https:\/\/doi.org\/10.3390\/plants9091240","journal-title":"Plants-Basel"},{"issue":"3","key":"3875_CR121","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.pharep.2016.12.011","volume":"69","author":"K-K Violetta","year":"2017","unstructured":"Violetta K-K, Jaros\u0142aw P, Wanda B-D (2017) The Nrf2-ARE signaling pathway: an update on its regulation and possible role in cancer prevention and treatment. Pharmacol Rep 69(3):393\u2013402","journal-title":"Pharmacol Rep"},{"key":"3875_CR122","doi-asserted-by":"publisher","first-page":"100889","DOI":"10.1016\/j.mam.2020.100889","volume":"76","author":"L Wang","year":"2020","unstructured":"Wang L, Hauenstein AV (2020) The NLRP3 inflammasome: Mechanism of action, role in disease and therapies. Mol Aspects Med 76:100889","journal-title":"Mol Aspects Med"},{"key":"3875_CR123","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1016\/j.biopha.2016.10.052","volume":"84","author":"B Wang","year":"2016","unstructured":"Wang B, Gao Y, Zheng G, Ren X, Sun B, Zhu K et al (2016) Platycodin D inhibits interleukin-13-induced the expression of inflammatory cytokines and mucus in nasal epithelial cells. Biomed Pharmacother 84:1108\u20131112. https:\/\/doi.org\/10.1016\/j.biopha.2016.10.052","journal-title":"Biomed Pharmacother"},{"key":"3875_CR124","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.ejphar.2017.07.037","volume":"814","author":"Y Wang","year":"2017","unstructured":"Wang Y, Zhang X, Wei Z, Wang J, Zhang Y, Shi M et al (2017) Platycodin D suppressed LPS-induced inflammatory response by activating LXR\u03b1 in LPS-stimulated primary bovine mammary epithelial cells. Eur J Pharmacol 814:138","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"3875_CR125","doi-asserted-by":"publisher","first-page":"3219","DOI":"10.1016\/j.bbrc.2018.08.129","volume":"503","author":"Y Wang","year":"2018","unstructured":"Wang Y, Che J, Zhao H, Tang J, Shi G (2018) Platycodin D inhibits oxidative stress and apoptosis in H9c2 cardiomyocytes following hypoxia\/reoxygenation injury. Biochem Biophys Res Commun 503(4):3219\u20133224","journal-title":"Biochem Biophys Res Commun"},{"issue":"18","key":"3875_CR126","doi-asserted-by":"publisher","first-page":"10339","DOI":"10.1021\/acs.jafc.3c07311","volume":"72","author":"W Wang","year":"2024","unstructured":"Wang W, Wang Z, Meng Z, Jiang S, Liu Z, Zhu H et al (2024) Platycodin D ameliorates type 2 diabetes-induced myocardial injury by activating the AMPK signaling pPathway. J Agric Food Chem 72(18):10339\u201310354. https:\/\/doi.org\/10.1021\/acs.jafc.3c07311","journal-title":"J Agric Food Chem"},{"issue":"12","key":"3875_CR127","doi-asserted-by":"publisher","first-page":"8702","DOI":"10.3390\/molecules15128702","volume":"15","author":"L Wei","year":"2010","unstructured":"Wei L, Wei Z, Lan X, Zi W, Yi-Nan Z, Ying-Ping W et al (2010) Platycoside N: a New Oleanane-type triterpenoid saponin from the roots of Platycodon grandiflorum. Molecules 15(12):8702\u20138708","journal-title":"Molecules"},{"issue":"8","key":"3875_CR128","doi-asserted-by":"publisher","first-page":"e29812","DOI":"10.1016\/j.heliyon.2024.e29812","volume":"10","author":"W Widowati","year":"2024","unstructured":"Widowati W, Darsono L, Utomo HS, Sabrina AHN, Natariza MR, Valentinus Tarigan AC et al (2024) Antidiabetic and hepatoprotection effect of butterfly pea flower (Clitoria ternatea L.) through antioxidant, anti-inflammatory, lower LDH, ACP, AST, and ALT on diabetes mellitus and dyslipidemia rat. Heliyon 10(8):e29812. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e29812","journal-title":"Heliyon"},{"issue":"8","key":"3875_CR129","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1248\/bpb.b-y110129","volume":"35","author":"J Wu","year":"2012","unstructured":"Wu J, Yang G, Zhu W, Wen W, Zhang F, Yuan J et al (2012) Anti-atherosclerotic Activity of Platycodin D Derived from Roots of Platycodon grandiflorum in Human Endothelial Cells. Biol Pharm Bullet 35(8):1216","journal-title":"Biol Pharm Bullet"},{"issue":"5","key":"3875_CR130","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.vaccine.2008.11.029","volume":"27","author":"Y Xie","year":"2009","unstructured":"Xie Y, Sun H-X, Li D (2009) Platycodin D is a potent adjuvant of specific cellular and humoral immune responses against recombinant hepatitis B antigen. Vaccine 27(5):757\u2013764","journal-title":"Vaccine"},{"issue":"3","key":"3875_CR131","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1002\/cbdv.200900183","volume":"7","author":"Y Xie","year":"2010","unstructured":"Xie Y, Sun HX, Li D (2010) Platycodin d improves the immunogenicity of newcastle disease virus-based recombinant avian influenza vaccine in mice. Chem Biodivers 7(3):677\u2013689","journal-title":"Chem Biodivers"},{"key":"3875_CR132","doi-asserted-by":"publisher","first-page":"1148853","DOI":"10.3389\/fphar.2023.1148853","volume":"14","author":"L Xie","year":"2023","unstructured":"Xie L, Zhao Y, Zheng Y, Li X (2023) The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus. Front Pharmacol 14:1148853. https:\/\/doi.org\/10.3389\/fphar.2023.1148853","journal-title":"Front Pharmacol"},{"issue":"12","key":"3875_CR133","doi-asserted-by":"publisher","first-page":"21411","DOI":"10.3390\/molecules191221411","volume":"19","author":"C Xu","year":"2014","unstructured":"Xu C, Sun G, Yuan G, Wang R, Sun X (2014) Effects of platycodin D on proliferation, apoptosis and PI3K\/Akt signal pathway of human glioma U251 cells. Molecules 19(12):21411\u201321423","journal-title":"Molecules"},{"issue":"1","key":"3875_CR134","doi-asserted-by":"publisher","first-page":"14041","DOI":"10.1038\/s41598-023-41196-0","volume":"13","author":"J Xu","year":"2023","unstructured":"Xu J, Hashino T, Tanaka R, Kawaguchi K, Yoshida H, Takao K (2023) The BCL-2 family protein BCL-RAMBO interacts and cooperates with GRP75 to promote its apoptosis signaling pathway. Sci Rep 13(1):14041. https:\/\/doi.org\/10.1038\/s41598-023-41196-0","journal-title":"Sci Rep"},{"issue":"9","key":"3875_CR135","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1002\/jcp.31087","volume":"238","author":"J Xu","year":"2023","unstructured":"Xu J, Li Y, Kang M, Chang C, Wei H, Zhang C et al (2023) Multiple forms of cell death: a focus on the PI3K\/AKT pathway. J Cell Physiol 238(9):2026\u20132038. https:\/\/doi.org\/10.1002\/jcp.31087","journal-title":"J Cell Physiol"},{"issue":"2023","key":"3875_CR136","doi-asserted-by":"publisher","first-page":"1138658","DOI":"10.3389\/fphar.2023.1138658","volume":"14","author":"Q Xu","year":"2023","unstructured":"Xu Q, Pan G, Wang Z, Wang L, Tang Y, Dong J et al (2023) Platycodin-D exerts its anti-cancer effect by promoting c-Myc protein ubiquitination and degradation in gastric cancer. Front Pharmacol 14(2023):1138658. https:\/\/doi.org\/10.3389\/fphar.2023.1138658","journal-title":"Front Pharmacol"},{"issue":"5","key":"3875_CR137","doi-asserted-by":"publisher","first-page":"227","DOI":"10.3390\/md22050227","volume":"22","author":"S Xu","year":"2024","unstructured":"Xu S, Li Z, Xin X, An F (2024) Curdepsidone A induces intrinsic apoptosis and inhibits protective autophagy via the ROS\/PI3K\/AKT signaling pathway in HeLa cells. Marine Drugs 22(5):227. https:\/\/doi.org\/10.3390\/md22050227","journal-title":"Marine Drugs"},{"issue":"1","key":"3875_CR138","doi-asserted-by":"publisher","first-page":"2310269","DOI":"10.1080\/08916934.2024.2310269","volume":"57","author":"S Xu","year":"2024","unstructured":"Xu S, Wang D, Tan L, Lu J (2024) The role of NLRP3 inflammasome in type 2 inflammation related diseases. Autoimmunity 57(1):2310269. https:\/\/doi.org\/10.1080\/08916934.2024.2310269","journal-title":"Autoimmunity"},{"issue":"2021","key":"3875_CR139","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/bs.accb.2021.10.001","volume":"79","author":"Y Yang","year":"2021","unstructured":"Yang Y, Laval S, Yu B (2021) Chemical synthesis of saponins. Adv Carbohydr Chem Biochem 79(2021):63\u2013150. https:\/\/doi.org\/10.1016\/bs.accb.2021.10.001","journal-title":"Adv Carbohydr Chem Biochem"},{"issue":"4","key":"3875_CR140","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/ol.2023.14040","volume":"26","author":"X Yang","year":"2023","unstructured":"Yang X, Yu B, Xi C, Song C, Yang R, Wang W et al (2023) A safety study on ultra-high or moderate static magnetic fields combined with platycodin D against lung cancer. Oncol Lett 26(4):1. https:\/\/doi.org\/10.3892\/ol.2023.14040","journal-title":"Oncol Lett"},{"issue":"1","key":"3875_CR141","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.etap.2013.03.012","volume":"36","author":"Y Ye","year":"2013","unstructured":"Ye Y, Han X, Guo B, Sun Z, Liu S (2013) Combination treatment with platycodin D and osthole inhibits cell proliferation and invasion in mammary carcinoma cell lines. Environ Toxicol Pharmacol 36(1):115\u2013124","journal-title":"Environ Toxicol Pharmacol"},{"key":"3875_CR142","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.intimp.2018.12.008","volume":"67","author":"Y Ye","year":"2019","unstructured":"Ye Y, Pei L, Ding J, Wu C, Sun C, Liu S (2019) Effects of platycodin D on S100A8\/A9-induced inflammatory response in murine mammary carcinoma 4T1 cells. Int Immunopharmacol 67:239\u2013247. https:\/\/doi.org\/10.1016\/j.intimp.2018.12.008","journal-title":"Int Immunopharmacol"},{"issue":"11","key":"3875_CR143","doi-asserted-by":"publisher","first-page":"2871","DOI":"10.3390\/molecules13112871","volume":"13","author":"C Yeon","year":"2008","unstructured":"Yeon C, Dae Y, Chun C, Mi-Ran C, Young K, Hyun L et al (2008) Platyconic acid A, a genuine triterpenoid saponin from the roots of Platycodon grandiflorum. Molecules 13(11):2871\u20132879","journal-title":"Molecules"},{"issue":"2","key":"3875_CR144","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1089\/jmf.2009.1226","volume":"13","author":"JS Yu","year":"2010","unstructured":"Yu JS, Kim AK (2010) Platycodin D induces apoptosis in MCF-7 Human Breast Cancer Cells. J Med Food 13(2):298\u2013305. https:\/\/doi.org\/10.1089\/jmf.2009.1226","journal-title":"J Med Food"},{"issue":"8","key":"3875_CR145","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1089\/jmf.2011.2024","volume":"15","author":"JS Yu","year":"2012","unstructured":"Yu JS, Kim AK (2012) Platycodin D induces reactive oxygen species-mediated apoptosis signal-regulating kinase 1 activation and endoplasmic reticulum stress response in human breast cancer cells. J Med Food 15(8):691\u2013699. https:\/\/doi.org\/10.1089\/jmf.2011.2024","journal-title":"J Med Food"},{"issue":"5","key":"3875_CR146","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1007\/s00403-022-02513-1","volume":"315","author":"Z Yu","year":"2023","unstructured":"Yu Z, Li Y, Fu R, Xue Y, Zhao D, Han D (2023) Platycodin D inhibits the proliferation and migration of hypertrophic scar-derived fibroblasts and promotes apoptosis through a caspase-dependent pathway. Arch Dermatol Res 315(5):1257\u20131267. https:\/\/doi.org\/10.1007\/s00403-022-02513-1","journal-title":"Arch Dermatol Res"},{"issue":"1","key":"3875_CR147","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1007\/s10735-024-10271-9","volume":"23","author":"W Yun","year":"2024","unstructured":"Yun W, Zhang J, Ji M (2024) Effects of Platycodon grandiflorus on doxorubicin resistance and epithelial\u2013mesenchymal transition of breast cancer cells via the p38 mitogen-activated protein kinase pathway. J Mol Histol 23(1):370. https:\/\/doi.org\/10.1007\/s10735-024-10271-9","journal-title":"J Mol Histol"},{"key":"3875_CR148","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.saa.2016.06.005","volume":"168","author":"CC Zeng","year":"2016","unstructured":"Zeng CC, Zhang C, Yao JH, Lai SH, Han BJ, Li W et al (2016) Platycodin D induced apoptosis and autophagy in PC-12 cells through mitochondrial dysfunction pathway. Spectrochimica Acta Part a Mol Biomol Spectrosc 168:199\u2013205","journal-title":"Spectrochimica Acta Part a Mol Biomol Spectrosc"},{"issue":"12","key":"3875_CR149","doi-asserted-by":"publisher","first-page":"14899","DOI":"10.3390\/molecules171214899","volume":"17","author":"Q Zhan","year":"2012","unstructured":"Zhan Q, Zhang F, Sun L, Wu Z, Chen W (2012) Two new oleanane-type triterpenoids from Platycodi Radix and anti-proliferative activity in HSC-T6 cells. Molecules (Basel, Switzerland) 17(12):14899\u201314907. https:\/\/doi.org\/10.3390\/molecules171214899","journal-title":"Molecules (Basel, Switzerland)"},{"issue":"11","key":"3875_CR150","doi-asserted-by":"publisher","first-page":"657","DOI":"10.3390\/v10110657","volume":"10","author":"M Zhang","year":"2018","unstructured":"Zhang M, Du T, Long F, Yang X, Sun Y, Duan M et al (2018) Platycodin D suppresses type 2 porcine reproductive and respiratory syndrome virus in primary and established cell lines. Viruses-Basel 10(11):657","journal-title":"Viruses-Basel"},{"issue":"6","key":"3875_CR151","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/ol.2020.12174","volume":"20","author":"X Zhang","year":"2020","unstructured":"Zhang X, Zhai T, Hei Z, Zhou D, Jin L, Han C et al (2020) Effects of platycodin D on apoptosis, migration, invasion and cell cycle arrest of gallbladder cancer cells. Oncol Lett 20(6):1. https:\/\/doi.org\/10.3892\/ol.2020.12174","journal-title":"Oncol Lett"},{"issue":"3","key":"3875_CR152","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1007\/s11064-020-03198-6","volume":"46","author":"J Zhang","year":"2021","unstructured":"Zhang J, Song N, Liu Y, Guo J (2021) Platycodin D nhibits \u03b2-amyloid-induced inflammation and oxidative stress in BV-2 cells via suppressing TLR4\/NF-\u03ba B signaling pathway and activating Nrf2\/HO-1 signaling pathway. Neurochem Res 46(3):638\u2013647","journal-title":"Neurochem Res"},{"issue":"3","key":"3875_CR153","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.chmed.2024.01.005","volume":"16","author":"L Zhang","year":"2024","unstructured":"Zhang L, Wang X, Zhang J, Liu D, Bai G (2024) Ethnopharmacology, phytochemistry, pharmacology and product application of Platycodon grandiflorum: a review. Chinese Herbal Med 16(3):327\u2013343. https:\/\/doi.org\/10.1016\/j.chmed.2024.01.005","journal-title":"Chinese Herbal Med"},{"issue":"3","key":"3875_CR154","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.chmed.2024.01.005","volume":"16","author":"L Zhang","year":"2024","unstructured":"Zhang L, Wang X, Zhang J, Liu D, Bai G (2024) Ethnopharmacology, phytochemistry, pharmacology and product application of Platycodon grandiflorum: a review. Chinese Herbal Med 16(3):327\u2013343. https:\/\/doi.org\/10.1016\/j.chmed.2024.01.005","journal-title":"Chinese Herbal Med"},{"key":"3875_CR155","doi-asserted-by":"publisher","unstructured":"Zhang Z, Zhao M, Zheng W, Liu Y (2017) Platycodin a triterpenoid saponin from Platycodon grandiflorum, suppresses the growth and invasion of human oral squamous cell carcinoma cells via the NF-\u03baB pathway: ZHANG ET\u00a0AL. J Biochem Mol Toxicol, 31(9):e21934. https:\/\/doi.org\/10.1002\/jbt.21934","DOI":"10.1002\/jbt.21934"},{"issue":"7","key":"3875_CR156","doi-asserted-by":"publisher","first-page":"952","DOI":"10.3923\/ijp.2018.952.962","volume":"14","author":"LC Zhao","year":"2018","unstructured":"Zhao LC, Liu Y, Wang Z, Tang N, Li W (2018) Liquid chromatography\/mass spectrometry analysis and hepatoprotective effect of steamed platycodi radix on acute alcohol-induced liver injury. Int J Pharmacol 14(7):952\u2013962. https:\/\/doi.org\/10.3923\/ijp.2018.952.962","journal-title":"Int J Pharmacol"},{"key":"3875_CR157","doi-asserted-by":"publisher","first-page":"102515","DOI":"10.1016\/j.jaut.2020.102515","volume":"113","author":"N Zhao","year":"2020","unstructured":"Zhao N, Li CC, Di B, Xu LL (2020) Recent advances in the NEK7-licensed NLRP3 inflammasome activation: mechanisms, role in diseases and related inhibitors. J Autoimm 113:102515","journal-title":"J Autoimm"},{"issue":"15","key":"3875_CR158","doi-asserted-by":"publisher","first-page":"2360","DOI":"10.3390\/cells11152360","volume":"11","author":"S Zheng","year":"2022","unstructured":"Zheng S, Xie Z, Xin Y, Lu W, Yang H, Lu T et al (2022) Whole transcriptome analysis identifies platycodin D-mediated rna regulatory network in non\u2013small-cell lung cancer. Cells (Basel, Switzerland) 11(15):2360. https:\/\/doi.org\/10.3390\/cells11152360","journal-title":"Cells (Basel, Switzerland)"},{"issue":"9","key":"3875_CR159","doi-asserted-by":"publisher","first-page":"860","DOI":"10.2174\/1568009614666141128104642","volume":"14","author":"R Zhou","year":"2014","unstructured":"Zhou R, Lu Z, Liu K, Guo J, Liu J, Zhou Y et al (2014) Platycodin D induces tumor growth arrest by activating FOXO3a expression in prostate cancer in vitro and in vivo. Curr Cancer Drug Targets 14(9):860. https:\/\/doi.org\/10.2174\/1568009614666141128104642","journal-title":"Curr Cancer Drug Targets"},{"issue":"2","key":"3875_CR160","doi-asserted-by":"publisher","first-page":"160","DOI":"10.2141\/jpsa.0180089","volume":"57","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, Zhou M, Mao S (2019) Adjuvant effects of platycodin D on immune responses to infectious bronchitis vaccine in chickens. J Poultry Sci 57(2):160\u2013167","journal-title":"J Poultry Sci"},{"issue":"1","key":"3875_CR161","doi-asserted-by":"publisher","first-page":"134","DOI":"10.3390\/cells11010134","volume":"11","author":"L Zhu","year":"2022","unstructured":"Zhu L, Han Z, He Y, Sun H (2022) Caspase-1-dependent pyroptosis mediates adjuvant activity of platycodin D as an adjuvant for intramuscular vaccines. Cells 11(1):134","journal-title":"Cells"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-03875-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-025-03875-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-03875-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T09:47:00Z","timestamp":1757152020000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-025-03875-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,11]]},"references-count":161,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["3875"],"URL":"https:\/\/doi.org\/10.1007\/s00210-025-03875-9","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,11]]},"assertion":[{"value":"15 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}