{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:09:58Z","timestamp":1792091398561,"version":"4.4.0"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Deanship of Research and Graduate Studies at Ajman University","award":["2023-IRG-PH-13"],"award-info":[{"award-number":["2023-IRG-PH-13"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s00210-025-03924-3","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T06:46:31Z","timestamp":1740552391000},"page":"10509-10522","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of lisinopril on cisplatin-induced inflammation, oxidative stress, apoptosis, and impaired steroidogenesis in rat testis: involvement of Nrf2\/Keap1\/HO-1 and PPAR\u03b3 signaling"],"prefix":"10.1007","volume":"398","author":[{"given":"El-Shaimaa A.","family":"Arafa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad H. M.","family":"Hassanein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha M.","family":"Hussein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafaa R.","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"key":"3924_CR1","doi-asserted-by":"crossref","unstructured":"Abdel Moneim AE, Othman MS, Aref AM (2014) Azadirachta indica attenuates cisplatin-induced nephrotoxicity and oxidative stress. BioMed Res Int 2014:647131","DOI":"10.1155\/2014\/647131"},{"key":"3924_CR2","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13155","volume":"44","author":"N Akaras","year":"2020","unstructured":"Akaras N, Abuc OO, Koc K, Bal T, Geyikoglu F, Atilay H, Erol HS, Yigit S, Gul M (2020) (1\u2192 3)-\u03b2-d-glucan enhances the toxicity induced by bortezomib in rat testis. J Food Biochem 44:e13155","journal-title":"J Food Biochem"},{"key":"3924_CR3","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1080\/10520295.2017.1350748","volume":"92","author":"N Akaras","year":"2017","unstructured":"Akaras N, Bal T, Atilay H, Selli J, Halici M (2017) Protective effects of agomelatine on testicular damage caused by bortezomib. Biotech Histochem 92:552\u2013559","journal-title":"Biotech Histochem"},{"key":"3924_CR4","first-page":"466","volume":"27","author":"N Akaras","year":"2024","unstructured":"Akaras N, G\u00fcr C, Caglayan C, Kandemir FM (2024) Protective effects of naringin against oxaliplatin-induced testicular damage in rats: involvement of oxidative stress, inflammation, endoplasmic reticulum stress, apoptosis, and histopathology. Iran J Basic Med Sci 27:466","journal-title":"Iran J Basic Med Sci"},{"key":"3924_CR5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.13005\/bpj\/1608","volume":"12","author":"SA Aldossary","year":"2019","unstructured":"Aldossary SA (2019) Review on pharmacology of cisplatin: clinical use, toxicity and mechanism of resistance of cisplatin. Biomed Pharmacol J 12:7\u201315","journal-title":"Biomed Pharmacol J"},{"key":"3924_CR6","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1007\/s10787-022-00998-w","volume":"30","author":"HH Arab","year":"2022","unstructured":"Arab HH, Abd El-Aal SA, Ashour AM, El-Sheikh AA, Al Khabbaz HJ, Arafa E-SA, Mahmoud AM, Kabel AM (2022) Targeting inflammation and redox perturbations by lisinopril mitigates Freund\u2019s adjuvant-induced arthritis in rats: role of JAK-2\/STAT-3\/RANKL axis, MMPs, and VEGF. Inflammopharmacology 30:1909\u20131926","journal-title":"Inflammopharmacology"},{"key":"3924_CR7","doi-asserted-by":"publisher","first-page":"e05985","DOI":"10.1016\/j.heliyon.2021.e05985","volume":"7","author":"GF Asaad","year":"2021","unstructured":"Asaad GF, Hassan A, Mostafa RE (2021) Anti-oxidant impact of lisinopril and enalapril against acute kidney injury induced by doxorubicin in male Wistar rats: Involvement of kidney injury molecule-1. Heliyon 7:e05985","journal-title":"Heliyon"},{"key":"3924_CR8","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.bionut.2012.08.005","volume":"2","author":"EA Awadalla","year":"2012","unstructured":"Awadalla EA (2012) Ameliorative effect of the crude oil of the Nigella sativa on oxidative stress induced in rat testes by cisplatin treatment. Biomed Prev Nutr 2:265\u2013268","journal-title":"Biomed Prev Nutr"},{"key":"3924_CR9","unstructured":"Bancroft JD, Gamble M (2008) Theory and practice of histological techniques. Elsevier health sciences"},{"key":"3924_CR10","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1097\/00005344-199203000-00005","volume":"19","author":"M Chopra","year":"1992","unstructured":"Chopra M, Beswick H, Clapperton M, Dargie HJ, Smith W, McMurray J (1992) Antioxidant effects of angiotensin-converting enzyme (ACE) inhibitors: free radical and oxidant scavenging are sulfhydryl dependent, but lipid peroxidation is inhibited by both sulfhydryl-and nonsulfhydryl-containing ACE inhibitors. J Cardiovasc Pharmacol 19:330\u2013340","journal-title":"J Cardiovasc Pharmacol"},{"key":"3924_CR11","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1002\/j.1939-4640.1986.tb00862.x","volume":"7","author":"MJ Cosentino","year":"1986","unstructured":"Cosentino MJ, Nishida M, Rabinowitz R, Cockett AT (1986) Histopathology of prepubertal rat testes subjected to various durations of spermatic cord torsion. J Androl 7:23\u201331","journal-title":"J Androl"},{"key":"3924_CR12","doi-asserted-by":"publisher","first-page":"573","DOI":"10.3390\/endocrines4030041","volume":"4","author":"K de Mattos","year":"2023","unstructured":"de Mattos K, Pierre KJ, Tremblay JJ (2023) Hormones and signaling pathways involved in the stimulation of Leydig cell steroidogenesis. Endocrines 4:573\u2013594","journal-title":"Endocrines"},{"key":"3924_CR13","doi-asserted-by":"publisher","first-page":"S541","DOI":"10.33549\/physiolres.934612","volume":"69","author":"I Dovinova","year":"2020","unstructured":"Dovinova I, Kvandova M, Balis P, Gresova L, Majzunova M, Horakova L, Julie Y, Barancik M (2020) The role of Nrf2 and PPAR\u03b3 in the improvement of oxidative stress in hypertension and cardiovascular diseases. Physiol Res 69:S541","journal-title":"Physiol Res"},{"key":"3924_CR14","doi-asserted-by":"publisher","first-page":"10043","DOI":"10.3390\/ijms221810043","volume":"22","author":"S Dutta","year":"2021","unstructured":"Dutta S, Sengupta P, Slama P, Roychoudhury S (2021) Oxidative stress, testicular inflammatory pathways, and male reproduction. Int J Mol Sci 22:10043","journal-title":"Int J Mol Sci"},{"key":"3924_CR15","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/s41572-023-00459-w","volume":"9","author":"ML Eisenberg","year":"2023","unstructured":"Eisenberg ML, Esteves SC, Lamb DJ, Hotaling JM, Giwercman A, Hwang K, Cheng Y-S (2023) Male infertility. Nat Rev Dis Primers 9:49","journal-title":"Nat Rev Dis Primers"},{"key":"3924_CR16","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","volume":"82","author":"GL Ellman","year":"1959","unstructured":"Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82:70\u201377","journal-title":"Arch Biochem Biophys"},{"key":"3924_CR17","doi-asserted-by":"publisher","first-page":"255","DOI":"10.5487\/TR.2017.33.3.255","volume":"33","author":"AR Fallahzadeh","year":"2017","unstructured":"Fallahzadeh AR, Rezaei Z, Rahimi HR, Barmak MJ, Sadeghi H, Mehrabi S, Rabani SM, Kashani IR, Barati V, Mahmoudi R (2017) Evaluation of the effect of pentoxifylline on cisplatin-induced testicular toxicity in rats. Toxicol Res 33:255\u2013263","journal-title":"Toxicol Res"},{"key":"3924_CR18","doi-asserted-by":"publisher","first-page":"458","DOI":"10.2174\/1871530320666200511073302","volume":"21","author":"AA Fard","year":"2021","unstructured":"Fard AA, Samadi M, Biabangard A (2021) Possible protective effects of curcumin via modulating of androgen receptor (AR) and Oct2 gene alterations in cisplatin-induced testicular toxicity in rat. Endocr Metab Immune Disord Drug Targets 21:458\u2013463","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"3924_CR19","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1080\/13880209.2017.1322618","volume":"55","author":"AA Fouad","year":"2017","unstructured":"Fouad AA, Qutub HO, Fouad AEA, Audeh AM, Al-Melhim WN (2017) Epigallocatechin-3-gallate counters cisplatin toxicity of rat testes. Pharm Biol 55:1710\u20131714","journal-title":"Pharm Biol"},{"key":"3924_CR20","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/nrurol.2011.26","volume":"8","author":"C Fung","year":"2011","unstructured":"Fung C, Vaughn DJ (2011) Complications associated with chemotherapy in testicular cancer management. Nat Rev Urol 8:213\u2013222","journal-title":"Nat Rev Urol"},{"key":"3924_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.102925","volume":"88","author":"S Ghosh","year":"2019","unstructured":"Ghosh S (2019) Cisplatin: the first metal based anticancer drug. Bioorg Chem 88:102925","journal-title":"Bioorg Chem"},{"key":"3924_CR22","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1007\/s11255-008-9348-5","volume":"40","author":"G Gokce","year":"2008","unstructured":"Gokce G, Karboga H, Yildiz E, Ayan S, Gultekin Y (2008) Effect of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on apoptotic changes in contralateral testis following unilateral testicular torsion. Int Urol Nephrol 40:989\u2013995","journal-title":"Int Urol Nephrol"},{"key":"3924_CR23","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1358\/dnp.2002.15.3.840011","volume":"15","author":"Y Guan","year":"2002","unstructured":"Guan Y, Zhang Y, Breyer MD (2002) The role of PPARs in the transcriptional control of cellular processes. Drug News Perspect 15:147\u2013154","journal-title":"Drug News Perspect"},{"key":"3924_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.109969","volume":"117","author":"EH Hassanein","year":"2023","unstructured":"Hassanein EH, Mohamed WR, Hussein RM, Arafa E-SA (2023) Edaravone alleviates methotrexate-induced testicular injury in rats: implications on inflammation, steroidogenesis, and Akt\/p53 signaling. Int Immunopharmacol 117:109969","journal-title":"Int Immunopharmacol"},{"key":"3924_CR25","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.tibs.2014.02.002","volume":"39","author":"JD Hayes","year":"2014","unstructured":"Hayes JD, Dinkova-Kostova AT (2014) The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Trends Biochem Sci 39:199\u2013218","journal-title":"Trends Biochem Sci"},{"key":"3924_CR26","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1093\/jncimonographs\/lgi003","volume":"2005","author":"SJ Howell","year":"2005","unstructured":"Howell SJ, Shalet SM (2005) Spermatogenesis after cancer treatment: damage and recovery. Jnci Monographs 2005:12\u201317","journal-title":"Jnci Monographs"},{"key":"3924_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2023.127287","volume":"80","author":"S Hussein","year":"2023","unstructured":"Hussein S, Kamel GAM (2023) Pioglitazone ameliorates cisplatin-induced testicular toxicity by attenuating oxidative stress and inflammation via TLR4\/MyD88\/NF-\u03baB signaling pathway. J Trace Elem Med Biol 80:127287","journal-title":"J Trace Elem Med Biol"},{"key":"3924_CR28","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23604","volume":"38","author":"M Ileriturk","year":"2024","unstructured":"Ileriturk M, Ileriturk D, Kandemir O, Akaras N, Simsek H, Erdogan E, Kandemir FM (2024) Naringin attenuates oxaliplatin-induced nephrotoxicity and hepatotoxicity: a molecular, biochemical, and histopathological approach in a rat model. J Biochem Mol Toxicol 38:e23604","journal-title":"J Biochem Mol Toxicol"},{"key":"3924_CR29","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1111\/j.1751-7176.2011.00508.x","volume":"13","author":"JL Izzo Jr","year":"2011","unstructured":"Izzo JL Jr, Weir MR (2011) Angiotensin-converting enzyme inhibitors. J Clin Hypertens 13:667","journal-title":"J Clin Hypertens"},{"key":"3924_CR30","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1007\/s00467-010-1477-2","volume":"25","author":"G Jia","year":"2010","unstructured":"Jia G, Kwon M, Liang HL, Mortensen J, Nilakantan V, Sweeney WE, Park F (2010) Chronic treatment with lisinopril decreases proliferative and apoptotic pathways in autosomal recessive polycystic kidney disease. Pediatr Nephrol 25:1139\u20131146","journal-title":"Pediatr Nephrol"},{"key":"3924_CR31","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1159\/000178170","volume":"1","author":"SG Johnsen","year":"1970","unstructured":"Johnsen SG (1970) Testicular biopsy score count\u2013a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Horm Res Paediatr 1:2\u201325","journal-title":"Horm Res Paediatr"},{"key":"3924_CR32","doi-asserted-by":"crossref","unstructured":"Kamel EO, Hassanein EHM, Ahmed MA, Ali FEM (2020) Perindopril ameliorates hepatic ischemia reperfusion injury via regulation of NF-\u03baB-p65\/TLR-4, JAK1\/STAT-3, Nrf-2, and PI3K\/Akt\/mTOR signaling pathways. Anat Rec (Hoboken, NJ : 2007) 303: 1935\u20131949","DOI":"10.1002\/ar.24292"},{"key":"3924_CR33","doi-asserted-by":"publisher","first-page":"114791","DOI":"10.1016\/j.fct.2024.114791","volume":"190","author":"NA Kank\u0131l\u0131\u00e7","year":"2024","unstructured":"Kank\u0131l\u0131\u00e7 NA, \u015eim\u015fek H, Akaras N, G\u00fcr C, K\u00fc\u00e7\u00fckler S, \u0130lerit\u00fcrk M, Gencer S, Kandemir FM (2024) The ameliorative effects of chrysin on bortezomib-induced nephrotoxicity in rats: reduces oxidative stress, endoplasmic reticulum stress, inflammation damage, apoptotic and autophagic death. Food Chem Toxicol 190:114791","journal-title":"Food Chem Toxicol"},{"key":"3924_CR34","first-page":"607","volume":"21","author":"S Karimi","year":"2018","unstructured":"Karimi S, Hosseinimehr SJ, Mohammadi HR, Khalatbary AR, Amiri FT (2018) Zataria multiflora ameliorates cisplatin-induced testicular damage via suppression of oxidative stress and apoptosis in a mice model. Iran J Basic Med Sci 21:607","journal-title":"Iran J Basic Med Sci"},{"key":"3924_CR35","doi-asserted-by":"publisher","unstructured":"Kosenko E, Suslikov A, Venediktova N, Kaminsky YG (2010) Erythrocyte antioxidant enzymes in hypertensive patients receiving lisinopril monotherapy or combined lisinopril plus simvastatin therapy. Biochem (Moscow) Suppl Ser B: Biomed Chem 4: 395\u2013399. https:\/\/doi.org\/10.1134\/S1990750810040128","DOI":"10.1134\/S1990750810040128"},{"key":"3924_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2174\/157489206775246458","volume":"1","author":"I Kostova","year":"2006","unstructured":"Kostova I (2006) Platinum complexes as anticancer agents. Recent Pat Anticancer Drug Discov 1:1\u201322","journal-title":"Recent Pat Anticancer Drug Discov"},{"key":"3924_CR37","doi-asserted-by":"publisher","unstructured":"Kruger NJ (2009) The Bradford method for protein quantitation. The protein protocols handbook. Springer: pp 17\u201324. https:\/\/doi.org\/10.1007\/978-1-59745-198-7_4","DOI":"10.1007\/978-1-59745-198-7_4"},{"key":"3924_CR38","doi-asserted-by":"publisher","first-page":"173","DOI":"10.2174\/1871530320666200516163919","volume":"21","author":"YA Kulkarni","year":"2021","unstructured":"Kulkarni YA, Suryavanshi SV (2021) Combination of naringenin and lisinopril ameliorates nephropathy in type-1 diabetic rats. Endocr Metab Immune Disord Drug Targets 21:173\u2013182","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"3924_CR39","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1677\/jme.0.0300263","volume":"30","author":"P Leung","year":"2003","unstructured":"Leung P, Sernia C (2003) The renin-angiotensin system and male reproduction: new functions for old hormones. J Mol Endocrinol 30:263\u2013270","journal-title":"J Mol Endocrinol"},{"key":"3924_CR40","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods (San Diego, Calif) 25:402\u2013408","journal-title":"Methods (San Diego, Calif)"},{"key":"3924_CR41","doi-asserted-by":"publisher","unstructured":"Mahmoud AM, Alexander MY, Tutar Y, Wilkinson FL, Venditti A (2017a) Oxidative stress in metabolic disorders and drug-induced injury: the potential role of Nrf2 and PPARs activators. Hindawi. https:\/\/doi.org\/10.1155\/2017\/2508909","DOI":"10.1155\/2017\/2508909"},{"key":"3924_CR42","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.biopha.2016.12.047","volume":"86","author":"AM Mahmoud","year":"2017","unstructured":"Mahmoud AM, Germoush MO, Alotaibi MF, Hussein OE (2017b) Possible involvement of Nrf2 and PPAR\u03b3 up-regulation in the protective effect of umbelliferone against cyclophosphamide-induced hepatotoxicity. Biomed Pharmacother 86:297\u2013306","journal-title":"Biomed Pharmacother"},{"key":"3924_CR43","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.biopha.2017.07.101","volume":"94","author":"AM Mahmoud","year":"2017","unstructured":"Mahmoud AM, Hozayen WG, Ramadan SM (2017c) Berberine ameliorates methotrexate-induced liver injury by activating Nrf2\/HO-1 pathway and PPAR\u03b3, and suppressing oxidative stress and apoptosis in rats. Biomed Pharmacother 94:280\u2013291","journal-title":"Biomed Pharmacother"},{"key":"3924_CR44","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.cbi.2017.04.009","volume":"270","author":"AM Mahmoud","year":"2017","unstructured":"Mahmoud AM, Hussein OE, Hozayen WG, Abd el-Twab SM, (2017d) Methotrexate hepatotoxicity is associated with oxidative stress, and down-regulation of PPAR\u03b3 and Nrf2: protective effect of 18\u03b2-glycyrrhetinic acid. Chem-Biol Interact 270:59\u201372","journal-title":"Chem-Biol Interact"},{"key":"3924_CR45","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0027-5107(85)90216-7","volume":"148","author":"SL Marklund","year":"1985","unstructured":"Marklund SL (1985) Superoxide dismutase isoenzymes in tissues and plasma from New Zealand black mice, nude mice and normal BALB\/c mice. Mutat Res 148:129\u2013134","journal-title":"Mutat Res"},{"key":"3924_CR46","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1038\/clpt.2011.265","volume":"91","author":"A Mbah","year":"2012","unstructured":"Mbah A, Ndukwu G, Ghasi S, Shu E, Ozoemena F, Mbah J, Onodugo O, Ejim E, Eze M, Nkwo P (2012) Low-dose lisinopril in normotensive men with idiopathic oligospermia and infertility: a 5-year randomized, controlled, crossover pilot study. Clin Pharmacol Ther 91:582\u2013589","journal-title":"Clin Pharmacol Ther"},{"key":"3924_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12894-021-00889-2","volume":"21","author":"B Mesbahzadeh","year":"2021","unstructured":"Mesbahzadeh B, Hassanzadeh-Taheri M, Aliparast M-s, Baniasadi P, Hosseini M (2021) The protective effect of crocin on cisplatin-induced testicular impairment in rats. BMC Urol 21:1\u20139","journal-title":"BMC Urol"},{"key":"3924_CR48","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0003-2697(78)90342-1","volume":"86","author":"M Mihara","year":"1978","unstructured":"Mihara M, Uchiyama M (1978) Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 86:271\u2013278","journal-title":"Anal Biochem"},{"key":"3924_CR49","first-page":"173","volume":"2","author":"D Mohammadnejad","year":"2012","unstructured":"Mohammadnejad D, Abedelahi A, Mohammadi-roshandeh A, Azami A (2012) Degenerative effect of cisplatin on testicular germinal epithelium. Adv Pharm Bull 2:173","journal-title":"Adv Pharm Bull"},{"key":"3924_CR50","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1038\/s41569-021-00569-6","volume":"18","author":"D Montaigne","year":"2021","unstructured":"Montaigne D, Butruille L, Staels B (2021) PPAR control of metabolism and cardiovascular functions. Nat Rev Cardiol 18:809\u2013823","journal-title":"Nat Rev Cardiol"},{"key":"3924_CR51","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.freeradbiomed.2013.02.008","volume":"66","author":"SK Niture","year":"2014","unstructured":"Niture SK, Khatri R, Jaiswal AK (2014) Regulation of Nrf2\u2014an update. Free Radic Biol Med 66:36\u201344","journal-title":"Free Radic Biol Med"},{"key":"3924_CR52","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1080\/01485010500398012","volume":"52","author":"B Okeahialam","year":"2006","unstructured":"Okeahialam B, Amadi K, Ameh A (2006) Effect of lisnopril, an angiotensin converting enzyme (ACE) inhibitor on spermatogenesis in rats. Arch Androl 52:209\u2013213","journal-title":"Arch Androl"},{"key":"3924_CR53","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/641087","volume":"2012","author":"S Polvani","year":"2012","unstructured":"Polvani S, Tarocchi M, Galli A (2012) PPARgamma and oxidative stress: con(beta) catenating NRF2 and FOXO. PPAR Res 2012:641087","journal-title":"PPAR Res"},{"key":"3924_CR54","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.14202\/vetworld.2018.1349-1356","volume":"11","author":"SA Prihatno","year":"2018","unstructured":"Prihatno SA, Padeta I, Larasati AD, Sundari B, Hidayati A, Fibrianto YH, Budipitojo T (2018) Effects of secretome on cisplatin-induced testicular dysfunction in rats. Veterinary World 11:1349","journal-title":"Veterinary World"},{"key":"3924_CR55","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1354\/vp.42-4-405","volume":"42","author":"JA Ramos-Vara","year":"2005","unstructured":"Ramos-Vara JA (2005) Technical aspects of immunohistochemistry. Vet Pathol 42:405\u2013426","journal-title":"Vet Pathol"},{"key":"3924_CR56","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.fct.2016.02.017","volume":"91","author":"KP Reddy","year":"2016","unstructured":"Reddy KP, Madhu P, Reddy PS (2016) Protective effects of resveratrol against cisplatin-induced testicular and epididymal toxicity in rats. Food Chem Toxicol 91:65\u201372","journal-title":"Food Chem Toxicol"},{"key":"3924_CR57","first-page":"291","volume":"23","author":"AC Ruifrok","year":"2001","unstructured":"Ruifrok AC, Johnston DA (2001) Quantification of histochemical staining by color deconvolution. Anal Quant Cytol Histol 23:291\u2013299","journal-title":"Anal Quant Cytol Histol"},{"key":"3924_CR58","doi-asserted-by":"publisher","first-page":"2502","DOI":"10.1111\/bcp.13705","volume":"84","author":"SR Sadat-Ebrahimi","year":"2018","unstructured":"Sadat-Ebrahimi SR, Parnianfard N, Vahed N, Babaei H, Ghojazadeh M, Tang S, Azarpazhooh A (2018) An evidence-based systematic review of the off-label uses of lisinopril. Br J Clin Pharmacol 84:2502\u20132521","journal-title":"Br J Clin Pharmacol"},{"key":"3924_CR59","doi-asserted-by":"crossref","unstructured":"Salem EA, Salem NA, Maarouf AM, Serefoglu EC, Hellstrom WJ (2012) Selenium and lycopene attenuate cisplatin-induced testicular toxicity associated with oxidative stress in Wistar rats. Urology 79: 1184. e1181\u20131184. e1186","DOI":"10.1016\/j.urology.2011.12.006"},{"key":"3924_CR60","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1002\/j.1939-4640.2005.tb02883.x","volume":"26","author":"P Sawhney","year":"2005","unstructured":"Sawhney P, Giammona CJ, Meistrich ML, Richburg JH (2005) Cisplatin-induced long-term failure of spermatogenesis in adult C57\/Bl\/6J mice. J Androl 26:136\u2013145","journal-title":"J Androl"},{"key":"3924_CR61","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.868365","volume":"13","author":"L Scisciola","year":"2022","unstructured":"Scisciola L, Fontanella RA, Garofalo G, Rizzo MR, Paolisso G, Barbieri M (2022) Potential role of lisinopril in reducing atherosclerotic risk: evidence of an antioxidant effect in human cardiomyocytes cell line. Front Pharmacol 13:868365","journal-title":"Front Pharmacol"},{"key":"3924_CR62","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121441","volume":"316","author":"AA Shaaban","year":"2023","unstructured":"Shaaban AA, Zaghloul RA, Kafl HE, El-Kashef DH (2023) Ameliorative effect of desloratadine against cisplatin-induced renal and testicular toxicity in rats: attention to TLR4\/NLRP3 inflammasome signaling pathway. Life Sci 316:121441","journal-title":"Life Sci"},{"key":"3924_CR63","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1002\/jbt.21593","volume":"28","author":"IO Sherif","year":"2014","unstructured":"Sherif IO, Abdel-Aziz A, Sarhan OM (2014) Cisplatin-induced testicular toxicity in rats: the protective effect of arjunolic acid. J Biochem Mol Toxicol 28:515\u2013521","journal-title":"J Biochem Mol Toxicol"},{"key":"3924_CR64","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1046\/j.1439-0272.2003.00536.x","volume":"35","author":"WE Siems","year":"2003","unstructured":"Siems WE, Maul B, Wiesner B, Becker M, Walther T, Rothe L, Winkler A (2003) Effects of kinins on mammalian spermatozoa and the impact of peptidolytic enzymes. Andrologia 35:44\u201354","journal-title":"Andrologia"},{"key":"3924_CR65","doi-asserted-by":"publisher","first-page":"307","DOI":"10.3390\/pathophysiology28020020","volume":"28","author":"J Thomas","year":"2021","unstructured":"Thomas J, Smith H, Smith CA, Coward L, Gorman G, De Luca M, Jumbo-Lucioni P (2021) The angiotensin-converting enzyme inhibitor lisinopril mitigates memory and motor deficits in a drosophila model of Alzheimer\u2019s disease. Pathophysiology 28:307\u2013319","journal-title":"Pathophysiology"},{"key":"3924_CR66","doi-asserted-by":"publisher","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","volume":"76","author":"H Towbin","year":"1979","unstructured":"Towbin H, Staehelin T, Gordon J (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76:4350\u20134354","journal-title":"Proc Natl Acad Sci USA"},{"key":"3924_CR67","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1016\/j.fertnstert.2007.04.059","volume":"89","author":"G T\u00fcrk","year":"2008","unstructured":"T\u00fcrk G, Ate\u015f\u015fahin A, S\u00f6nmez M, \u00c7eriba\u015fi AO, Y\u00fcce A (2008) Improvement of cisplatin-induced injuries to sperm quality, the oxidant-antioxidant system, and the histologic structure of the rat testis by ellagic acid. Fertil Steril 89:1474\u20131481","journal-title":"Fertil Steril"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-03924-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-025-03924-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-03924-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T07:25:45Z","timestamp":1757143545000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-025-03924-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,26]]},"references-count":67,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["3924"],"URL":"https:\/\/doi.org\/10.1007\/s00210-025-03924-3","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,26]]},"assertion":[{"value":"17 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}