{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:17:49Z","timestamp":1790198269415,"version":"4.1.0"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s00210-025-03984-5","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T12:31:45Z","timestamp":1741350705000},"page":"10921-10937","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Anti-arthritic potential of linalool: in vitro, in vivo, and in silico mechanistic insights for safer therapeutic applications"],"prefix":"10.1007","volume":"398","author":[{"given":"Shoyaeb","family":"Ahammed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raihan","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Sakib","family":"Al Hasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emon","family":"Mia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Showkoth","family":"Akbor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Tahajul","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rokibul Islam","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Sabbir","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irfan Aamer","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddique Akber","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Amirul","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainab M.","family":"Almarhoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javad","family":"Sharifi-Rad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William N.","family":"Setzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Torequl","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,7]]},"reference":[{"issue":"5","key":"3984_CR1","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1093\/bib\/bbz103","volume":"21","author":"FE Agamah","year":"2020","unstructured":"Agamah FE, Mazandu GK, Hassan R, Bope CD, Thomford NE, Ghansah A, Chimusa ER (2020) Computational\/in silico methods in drug target and lead prediction. Brief Bioinform 21(5):1663\u20131675. https:\/\/doi.org\/10.1093\/bib\/bbz103","journal-title":"Brief Bioinform"},{"key":"3984_CR2","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.cca.2020.11.003","volume":"512","author":"M Akram","year":"2021","unstructured":"Akram M, Daniyal M, Sultana S, Owais A, Akhtar N, Zahid R, Said F, Bouyahya A, Ponomarev E, Ali Shariat M, Thiruvengadam M (2021) Traditional and modern management strategies for rheumatoid arthritis. Clin Chim Acta: Int J Clin Chem 512:142\u2013155. https:\/\/doi.org\/10.1016\/j.cca.2020.11.003","journal-title":"Clin Chim Acta: Int J Clin Chem"},{"issue":"12","key":"3984_CR3","doi-asserted-by":"publisher","first-page":"e202400874","DOI":"10.1002\/cbdv.202400874","volume":"21","author":"A Aktar","year":"2024","unstructured":"Aktar A, Bhuia S, Chowdhury R, Ferdous J, Khatun M, Hasan SA, Mia E, Hasan R, Islam MT (2024) An insight of plant source, toxicological profile, and pharmacological activities of iridoid loganic acid: a comprehensivereview. Chem Biodivers 21(12):e202400874. https:\/\/doi.org\/10.1002\/cbdv.202400874","journal-title":"Chem Biodivers"},{"key":"3984_CR4","doi-asserted-by":"crossref","unstructured":"Al Hasan MS, Mia E, Yana NT, Rakib IH, Bhuia MS, Chowdhury R, ... and Islam MT (2024) Allium cepa bioactive phytochemicals as potent ALK (Anaplastic lymphoma kinase) inhibitors and therapeutic agents against non-small cell lung cancer (NSCLC): a computational study. Pharmacol Res-Nat Prod 5:100124","DOI":"10.1016\/j.prenap.2024.100124"},{"key":"3984_CR5","doi-asserted-by":"publisher","first-page":"159089","DOI":"10.1155\/2014\/159089","volume":"2014","author":"A Al-Nahain","year":"2014","unstructured":"Al-Nahain A, Jahan R, Rahmatullah M (2014) Zingiber officinale: a potential plant against rheumatoid arthritis. Arthritis 2014:159089. https:\/\/doi.org\/10.1155\/2014\/159089","journal-title":"Arthritis"},{"issue":"21","key":"3984_CR6","doi-asserted-by":"publisher","first-page":"10370","DOI":"10.1039\/d1fo02120f","volume":"12","author":"Q An","year":"2021","unstructured":"An Q, Ren JN, Li X, Fan G, Qu SS, Song Y, Li Y, Pan SY (2021) Recent updates on bioactive properties of linalool. Food Funct 12(21):10370\u201310389. https:\/\/doi.org\/10.1039\/d1fo02120f","journal-title":"Food Funct"},{"issue":"15","key":"3984_CR7","doi-asserted-by":"publisher","first-page":"8140","DOI":"10.3390\/ijms23158140","volume":"23","author":"M Arleevskaya","year":"2022","unstructured":"Arleevskaya M, Takha E, Petrov S, Kazarian G, Renaudineau Y, Brooks W, Larionova R, Korovina M, Valeeva A, Shuralev E, Mukminov M, Kravtsova O, Novikov A (2022) Interplay of environmental, individual and genetic factors in rheumatoid arthritis provocation. Int J Mol Sci 23(15):8140. https:\/\/doi.org\/10.3390\/ijms23158140","journal-title":"Int J Mol Sci"},{"issue":"W1","key":"3984_CR8","doi-asserted-by":"publisher","first-page":"W513","DOI":"10.1093\/nar\/gkae303","volume":"52","author":"P Banerjee","year":"2024","unstructured":"Banerjee P, Kemmler E, Dunkel M, Preissner R (2024) ProTox 3.0: a webserver for the prediction of toxicity of chemicals. Nucleic Acids Res 52(W1):W513\u2013W520. https:\/\/doi.org\/10.1093\/nar\/gkae303","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"3984_CR9","first-page":"981","volume":"3","author":"VK Baranwal","year":"2012","unstructured":"Baranwal VK, Irchhaiya R, Alok S (2012) Anti-arthritic activity of some indigenous plants: a review. Int J Pharm Sci Res 3(4):981\u2013986","journal-title":"Int J Pharm Sci Res"},{"issue":"3","key":"3984_CR10","first-page":"482","volume":"16","author":"CC Barua","year":"2017","unstructured":"Barua CC, Bodduluru LN, Haloi P, Purukayastha A, Patowary P, Hussain M, Bora M (2017) Anti-arthritic and anti-inflammatory activity of a polyherbal formulation against Freund\u2019s complete adjuvant induced arthritis in Wistar rats. Indian J Tradit Knowl 16(3):482\u2013489","journal-title":"Indian J Tradit Knowl"},{"issue":"11","key":"3984_CR11","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1016\/j.jpain.2010.02.022","volume":"11","author":"PA Batista","year":"2010","unstructured":"Batista PA, Werner MF, Oliveira EC, Burgos L, Pereira P, Brum LF, Story GM, Santos AR (2010) The antinociceptive effect of (-)-linalool in models of chronic inflammatory and neuropathic hypersensitivity in mice. J Pain 11(11):1222\u20131229. https:\/\/doi.org\/10.1016\/j.jpain.2010.02.022","journal-title":"J Pain"},{"key":"3984_CR12","doi-asserted-by":"crossref","unstructured":"Bhuia MS, Kamli H, Islam T, Sonia FA, Kazi MA, Siam MSH, ... and Islam MT (2023) Antiemetic activity of trans-ferulic acid possibly through muscarinic receptors interaction pathway: In vivo and in silico study.\u00a0Results Chem 6:101014","DOI":"10.1016\/j.rechem.2023.101014"},{"key":"3984_CR13","doi-asserted-by":"publisher","first-page":"612","DOI":"10.3389\/fchem.2020.00612","volume":"8","author":"S Brogi","year":"2020","unstructured":"Brogi S, Ramalho TC, Kuca K, Medina-Franco JL, Valko M (2020) Editorial: In silico Methods for Drug Design and Discovery. Front Chem 8:612. https:\/\/doi.org\/10.3389\/fchem.2020.00612","journal-title":"Front Chem"},{"issue":"17","key":"3984_CR14","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.3889\/oamjms.2019.559","volume":"7","author":"V Chinnasamy","year":"2019","unstructured":"Chinnasamy V, Subramaniyan V, Chandiran S, Kayarohanam S, Kanniyan DC, Velaga VSSR, Muhammad S (2019) Antiarthritic activity of Achyranthes Aspera on formaldehyde - induced arthritis in rats. Open Access Maced J Med Sci 7(17):2709\u20132714. https:\/\/doi.org\/10.3889\/oamjms.2019.559","journal-title":"Open Access Maced J Med Sci"},{"issue":"2","key":"3984_CR15","first-page":"199","volume":"52","author":"M Choudhary","year":"2014","unstructured":"Choudhary M, Kumar V, Gupta PK, Singh S (2014) Anti-arthritic activity of Barleria prionitis Linn. leaves in acute and chronic models in Sprague Dawley rats. Bull Fac Pharm Cairo Univ 52(2):199\u2013209","journal-title":"Bull Fac Pharm Cairo Univ"},{"issue":"01","key":"3984_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.71193\/jpci.20250001","volume":"1","author":"R Chowdhury","year":"2025","unstructured":"Chowdhury R, Al Hasan MS (2025) Assessments of membrane stabilizing and clot lysis capacity of Canna indica flower aqueous extract: In vitro study. J Phytochem Insights 1(01):1\u20137","journal-title":"J Phytochem Insights"},{"key":"3984_CR17","doi-asserted-by":"publisher","first-page":"105704","DOI":"10.1016\/j.neuint.2024.105704","volume":"175","author":"R Chowdhury","year":"2024","unstructured":"Chowdhury R, Bhuia MS, Al Hasan MS, Ansari SA, Ansari IA, Gurgel APAD, Coutinho HDM, Islam MT (2024) Anticonvulsant effect of (\u00b1) citronellal possibly through the GABAergic and voltage-gated sodium channel receptor interaction pathways: In vivo and in silico studies. Neurochem Int 175:105704. https:\/\/doi.org\/10.1016\/j.neuint.2024.105704","journal-title":"Neurochem Int"},{"issue":"3","key":"3984_CR18","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.semarthrit.2016.05.012","volume":"46","author":"LC Coates","year":"2016","unstructured":"Coates LC, FitzGerald O, Helliwell PS, Paul C (2016) Psoriasis, psoriatic arthritis, and rheumatoid arthritis: is all inflammation the same? Semin Arthritis Rheum 46(3):291\u2013304. https:\/\/doi.org\/10.1016\/j.semarthrit.2016.05.012","journal-title":"Semin Arthritis Rheum"},{"issue":"17","key":"3984_CR19","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.2174\/0113895575261945231122062659","volume":"24","author":"PR da Silva","year":"2024","unstructured":"da Silva PR, Nunes Pazos ND, de Andrade JC, de Sousa NF, Oliveira Pires HF, de Figueiredo Lima JL, Dias AL, da Silva Stiebbe Salvadori MG, de Oliveira Golzio AMF, de Castro RD, Scotti MT, Patil VM, Bezerra Felipe CF, de Almeida RN, Scotti L (2024) An in silico approach to exploring the antinociceptive biological activities of linalool and its metabolites. Mini Rev Med Chem 24(17):1556\u20131574. https:\/\/doi.org\/10.2174\/0113895575261945231122062659","journal-title":"Mini Rev Med Chem"},{"issue":"6\u20132011","key":"3984_CR20","first-page":"269","volume":"1","author":"P Dey","year":"2011","unstructured":"Dey P, Chatterjee P, Chandra S, Bhattacharya S (2011) Comparative in vitro evaluation of anti-inflammatory effects of aerial parts and roots from Mikania scandens. J Adv Pharm Educ Res 1(6\u20132011):269\u2013277","journal-title":"J Adv Pharm Educ Res"},{"issue":"1","key":"3984_CR21","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/s41392-023-01331-9","volume":"8","author":"Q Ding","year":"2023","unstructured":"Ding Q, Hu W, Wang R, Yang Q, Zhu M, Li M, Cai J, Rose P, Mao J, Zhu YZ (2023) Signaling pathways in rheumatoid arthritis: implications for targeted therapy. Signal Transduct Target Ther 8(1):68. https:\/\/doi.org\/10.1038\/s41392-023-01331-9","journal-title":"Signal Transduct Target Ther"},{"issue":"6","key":"3984_CR22","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.2174\/1570159X19666210920094504","volume":"20","author":"\u00c9RQ Dos Santos","year":"2022","unstructured":"Dos Santos \u00c9RQ, Maia JGS, Fontes-J\u00fanior EA, do Socorro Ferraz Maia C (2022) Linalool as a therapeutic and medicinal tool in depression treatment: a review. Curr Neuropharmacol 20(6):1073\u20131092. https:\/\/doi.org\/10.2174\/1570159X19666210920094504","journal-title":"Curr Neuropharmacol"},{"issue":"2","key":"3984_CR23","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1007\/s10787-022-00949-5","volume":"30","author":"SI Haider","year":"2022","unstructured":"Haider SI, Asif A, Rasheed HMF, Akram A, Jabeen Q (2022) Caralluma tuberculata exhibits analgesic and anti-arthritic potential by downregulating pro-inflammatory cytokines and attenuating oxidative stress. Inflammopharmacology 30(2):621\u2013638. https:\/\/doi.org\/10.1007\/s10787-022-00949-5","journal-title":"Inflammopharmacology"},{"issue":"4","key":"3984_CR24","doi-asserted-by":"publisher","first-page":"807","DOI":"10.3329\/bjp.v10i4.23779","volume":"10","author":"UH Hasan","year":"2015","unstructured":"Hasan UH, Uttra AM, Rasool S (2015) Evaluation of in vitro and in vivo anti-arthritic potential of Berberis calliobotrys. Bangladesh J Pharmacol 10(4):807\u2013819","journal-title":"Bangladesh J Pharmacol"},{"key":"3984_CR25","doi-asserted-by":"publisher","first-page":"109298","DOI":"10.1016\/j.compbiomed.2024.109298","volume":"183","author":"R Hasan","year":"2024","unstructured":"Hasan R, Bhuia MS, Chowdhury R, Saha S, Khan MA, Afroz M, Ansari SA, Ansari IA, Melo Coutinho HD, Islam MT (2024) Abietic acid antagonizes the anti-inflammatory effects of celecoxib and ketoprofen: preclinical assessment and molecular dynamic simulations. Comput Biol Med 183:109298. https:\/\/doi.org\/10.1016\/j.compbiomed.2024.109298","journal-title":"Comput Biol Med"},{"issue":"9","key":"3984_CR26","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1002\/ptr.3736","volume":"26","author":"H Hosseinzadeh","year":"2012","unstructured":"Hosseinzadeh H, Imenshahidi M, Hosseini M, Razavi BM (2012) Effect of linalool on morphine tolerance and dependence in mice. Phytother Res 26(9):1399\u20131404","journal-title":"Phytother Res"},{"issue":"1","key":"3984_CR27","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1016\/j.jss.2012.10.050","volume":"180","author":"M Huo","year":"2013","unstructured":"Huo M, Cui X, Xue J, Chi G, Gao R, Deng X, Guan S, Wei J, Soromou LW, Feng H, Wang D (2013) Anti-inflammatory effects of linalool in RAW 264.7 macrophages and lipopolysaccharide-induced lung injury model. J Surg Res 180(1):e47\u2013e54. https:\/\/doi.org\/10.1016\/j.jss.2012.10.050","journal-title":"J Surg Res"},{"issue":"6","key":"3984_CR28","doi-asserted-by":"publisher","first-page":"3255","DOI":"10.1007\/s11030-022-10389-6","volume":"26","author":"MAA Ibrahim","year":"2022","unstructured":"Ibrahim MAA, Abdelrahman AHM, Badr EAA, Almansour NM, Alzahrani OR, Ahmed MN, Soliman MES, Naeem MA, Shawky AM, Sidhom PA, Mekhemer GAH, Atia MAM (2022) Naturally occurring plant-based anticancerous candidates as prospective ABCG2 inhibitors: an in silico drug discovery study. Mol Divers 26(6):3255\u20133277. https:\/\/doi.org\/10.1007\/s11030-022-10389-6","journal-title":"Mol Divers"},{"key":"3984_CR29","doi-asserted-by":"publisher","first-page":"138060","DOI":"10.1016\/j.neulet.2024.138060","volume":"845","author":"MT Islam","year":"2025","unstructured":"Islam MT, Al Hasan MS, Ferdous J, Mia E, Yana NT, Ansari IA, Ansari SA, Islam MA, Coutinho HDM (2025) GabaAergic sedative prospection of sclareol-linalool co-treatment: an antagonistic intervention through in vivo and in silico studies. Neurosci Lett 845:138060. https:\/\/doi.org\/10.1016\/j.neulet.2024.138060","journal-title":"Neurosci Lett"},{"key":"3984_CR30","doi-asserted-by":"publisher","unstructured":"Islam MT, Al Hasan MS, Chowdhury R, Mia E, Rakib IH, Yana NT, El-Nashar HAS, Ansari SA, Ansari IA, Islam MA, Almarhoon ZM, Setzer WN, Sharifi-Rad J (2024) Unveiling the anxiolytic and analgesic effects of citronellal in Swiss mice: in vivo and in silico insights into COX and GABAA receptor pathways. Naunyn-Schmiedeberg's Arch Pharmacol.https:\/\/doi.org\/10.1007\/s00210-024-03665-9. Advance online publication. https:\/\/doi.org\/10.1007\/s00210-024-03665-9","DOI":"10.1007\/s00210-024-03665-9"},{"issue":"6","key":"3984_CR31","doi-asserted-by":"publisher","first-page":"556","DOI":"10.2174\/1389200218666170316093301","volume":"18","author":"NT Issa","year":"2017","unstructured":"Issa NT, Wathieu H, Ojo A, Byers SW, Dakshanamurthy S (2017) Drug metabolism in preclinical drug development: a survey of the discovery process, toxicology, and computational tools. Curr Drug Metab 18(6):556\u2013565. https:\/\/doi.org\/10.2174\/1389200218666170316093301","journal-title":"Curr Drug Metab"},{"key":"3984_CR32","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1186\/1471-2105-13-173","volume":"13","author":"MU Johansson","year":"2012","unstructured":"Johansson MU, Zoete V, Michielin O, Guex N (2012) Defining and searching for structural motifs using DeepView\/Swiss-PdbViewer. BMC Bioinforma 13:173. https:\/\/doi.org\/10.1186\/1471-2105-13-173","journal-title":"BMC Bioinforma"},{"key":"3984_CR33","doi-asserted-by":"publisher","first-page":"115768","DOI":"10.1016\/j.biopha.2023.115768","volume":"168","author":"H Kamli","year":"2023","unstructured":"Kamli H, Shaikh A, Bappi MH, Raposo A, Ahmad MF, Sonia FA, Akbor MS, Prottay AAS, Gon\u00e7alves SA, Ara\u00fajo IM, Coutinho HDM, Elbendary EY, Lho LH, Han H, Islam MT (2023) Sclareol exerts synergistic antidepressant effects with quercetin and caffeine, possibly suppressing GABAergic transmission in chicks. Biomed Pharmacother Biomedecine Pharmacotherapie 168:115768. https:\/\/doi.org\/10.1016\/j.biopha.2023.115768","journal-title":"Biomed Pharmacother Biomedecine Pharmacotherapie"},{"issue":"6","key":"3984_CR34","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.3390\/jcm9062008","volume":"9","author":"JW Kim","year":"2020","unstructured":"Kim JW, Suh CH (2020) Systemic manifestations and complications in patients with rheumatoid arthritis. J Clin Med 9(6):2008. https:\/\/doi.org\/10.3390\/jcm9062008","journal-title":"J Clin Med"},{"key":"3984_CR35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s43094-019-0015-8","volume":"6","author":"GK Kiriiri","year":"2020","unstructured":"Kiriiri GK, Njogu PM, Mwangi AN (2020) Exploring different approaches to improve the success of drug discovery and development projects: a review. Future J Pharm Sci 6:1\u201312","journal-title":"Future J Pharm Sci"},{"issue":"5","key":"3984_CR36","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1111\/joim.13058","volume":"287","author":"L Klareskog","year":"2020","unstructured":"Klareskog L, R\u00f6nnelid J, Saevarsdottir S, Padyukov L, Alfredsson L (2020) The importance of differences; on environment and its interactions with genes and immunity in the causation of rheumatoid arthritis. J Int Med 287(5):514\u2013533. https:\/\/doi.org\/10.1111\/joim.13058","journal-title":"J Int Med"},{"key":"3984_CR37","doi-asserted-by":"publisher","unstructured":"Kolasinski SL, Neogi T, Hochberg MC, Oatis C, Guyatt G, Block J, Callahan L, Copenhaver C, Dodge C, Felson D, Gellar K, Harvey WF, Hawker G, Herzig E, Kwoh CK, Nelson AE, Samuels J, Scanzello C, White D, Wise B, \u2026 Reston J (2020) 2019 American College of Rheumatology\/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee.\u00a0Arthritis Rheumatol (Hoboken, N.J.),\u00a072(2), 220\u2013233. https:\/\/doi.org\/10.1002\/art.41142","DOI":"10.1002\/art.41142"},{"issue":"10","key":"3984_CR38","first-page":"3894","volume":"4","author":"V Kumar","year":"2013","unstructured":"Kumar V, Verma A, Ahmed D, Sachan NK, Anwar F, Mujeeb M (2013) Fostered antiarthritic upshot of moringa oleifera lam. stem bark extract in diversely induced arthritis in wistar rats with plausible mechanism. Int J Pharm Sci Res 4(10):3894","journal-title":"Int J Pharm Sci Res"},{"issue":"1","key":"3984_CR39","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/jphp.12156","volume":"66","author":"M Kuncha","year":"2014","unstructured":"Kuncha M, Naidu VG, Sahu BD, Gadepalli SG, Sistla R (2014) Curcumin potentiates the anti-arthritic effect of prednisolone in Freund\u2019s complete adjuvant-induced arthritic rats. J Pharm Pharmacol 66(1):133\u2013144. https:\/\/doi.org\/10.1111\/jphp.12156","journal-title":"J Pharm Pharmacol"},{"key":"3984_CR40","doi-asserted-by":"publisher","first-page":"114246","DOI":"10.1016\/j.jep.2021.114246","volume":"278","author":"P Kuralkar","year":"2021","unstructured":"Kuralkar P, Kuralkar SV (2021) Role of herbal products in animal production - an updated review. J Ethnopharmacol 278:114246. https:\/\/doi.org\/10.1016\/j.jep.2021.114246","journal-title":"J Ethnopharmacol"},{"key":"3984_CR41","doi-asserted-by":"publisher","first-page":"106347","DOI":"10.1016\/j.prostaglandins.2019.106347","volume":"144","author":"HH Lee","year":"2019","unstructured":"Lee HH, Moon Y, Shin JS, Lee JH, Kim TW, Jang C, Park C, Lee J, Kim Y, Kim Y, Werz O, Park BY, Lee JY, Lee KT (2019) A novel mPGES-1 inhibitor alleviates inflammatory responses by downregulating PGE2 in experimental models. Prostaglandins Other Lipid Mediat 144:106347. https:\/\/doi.org\/10.1016\/j.prostaglandins.2019.106347","journal-title":"Prostaglandins Other Lipid Mediat"},{"issue":"1","key":"3984_CR42","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.jep.2014.05.023","volume":"155","author":"B Lin","year":"2014","unstructured":"Lin B, Zhao Y, Han P, Yue W, Ma XQ, Rahman K, Zheng CJ, Qin LP, Han T (2014) Anti-arthritic activity of Xanthium strumarium L. extract on complete Freund\u05f3s adjuvant induced arthritis in rats. J Ethnopharmacol 155(1):248\u2013255. https:\/\/doi.org\/10.1016\/j.jep.2014.05.023","journal-title":"J Ethnopharmacol"},{"key":"3984_CR43","doi-asserted-by":"publisher","first-page":"106823","DOI":"10.1016\/j.intimp.2020.106823","volume":"88","author":"F Liu","year":"2020","unstructured":"Liu F, Liu Y, Zhan S, Lv J, Sun F, Weng B, Liu S, Xia P (2020) Chebulanin exerts its anti-inflammatory and anti-arthritic effects via inhibiting NF-\u03baB and MAPK activation in collagen-induced arthritis mice. Int Immunopharmacol 88:106823. https:\/\/doi.org\/10.1016\/j.intimp.2020.106823","journal-title":"Int Immunopharmacol"},{"issue":"3","key":"3984_CR44","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3892\/mmr.2022.12615","volume":"25","author":"S Liu","year":"2022","unstructured":"Liu S, Deng Z, Chen K, Jian S, Zhou F, Yang Y, Fu Z, Xie H, Xiong J, Zhu W (2022) Cartilage tissue engineering: from proinflammatory and anti-inflammatory cytokines to osteoarthritis treatments (Review). Mol Med Rep 25(3):99. https:\/\/doi.org\/10.3892\/mmr.2022.12615","journal-title":"Mol Med Rep"},{"issue":"8","key":"3984_CR45","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1111\/j.1745-7254.2005.00150.x","volume":"26","author":"C Luo","year":"2005","unstructured":"Luo C, He ML, Bohlin L (2005) Is COX-2 a perpetrator or a protector? Selective COX-2 inhibitors remain controversial. Acta Pharmacol Sin 26(8):926\u2013933. https:\/\/doi.org\/10.1111\/j.1745-7254.2005.00150.x","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"3984_CR46","doi-asserted-by":"publisher","first-page":"162","DOI":"10.55563\/clinexprheumatol\/1jlh15","volume":"39","author":"Y Ma","year":"2021","unstructured":"Ma Y, Hong FF, Yang SL (2021) Role of prostaglandins in rheumatoid arthritis. Clin Exp Rheumatol 39(1):162\u2013172. https:\/\/doi.org\/10.55563\/clinexprheumatol\/1jlh15","journal-title":"Clin Exp Rheumatol"},{"issue":"14","key":"3984_CR47","doi-asserted-by":"publisher","first-page":"7891","DOI":"10.3390\/ijms23147891","volume":"23","author":"JJ McDougall","year":"2022","unstructured":"McDougall JJ, McKenna MK (2022) Anti-inflammatory and analgesic properties of the cannabis terpene myrcene in rat adjuvant monoarthritis. Int J Mol Sci 23(14):7891. https:\/\/doi.org\/10.3390\/ijms23147891","journal-title":"Int J Mol Sci"},{"issue":"10278","key":"3984_CR48","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1016\/S0140-6736(20)32598-8","volume":"397","author":"F Meric-Bernstam","year":"2021","unstructured":"Meric-Bernstam F, Larkin J, Tabernero J, Bonini C (2021) Enhancing anti-tumour efficacy with immunotherapy combinations. Lancet (London, England) 397(10278):1010\u20131022. https:\/\/doi.org\/10.1016\/S0140-6736(20)32598-8","journal-title":"Lancet (London, England)"},{"issue":"10","key":"3984_CR49","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1111\/j.2042-7158.1972.tb08882.x","volume":"24","author":"Y Mizushima","year":"1972","unstructured":"Mizushima Y, Tsukada W, Akimoto T (1972) A modification of rat adjuvant arthritis for testing antirheumatic drugs. J Pharm Pharmacol 24(10):781\u2013785. https:\/\/doi.org\/10.1111\/j.2042-7158.1972.tb08882.x","journal-title":"J Pharm Pharmacol"},{"issue":"17","key":"3984_CR50","doi-asserted-by":"publisher","first-page":"9208","DOI":"10.3390\/ijms22179208","volume":"22","author":"V Molnar","year":"2021","unstructured":"Molnar V, Mati\u0161i\u0107 V, Kodvanj I, Bjelica R, Jele\u010d \u017d, Hudetz D, Rod E, \u010cukelj F, Vrdoljak T, Vidovi\u0107 D, Stare\u0161ini\u0107 M, Sabali\u0107 S, Dobri\u010di\u0107 B, Petrovi\u0107 T, Anti\u010devi\u0107 D, Bori\u0107 I, Ko\u0161ir R, Zmrzljak UP, Primorac D (2021) Cytokines and chemokines involved in osteoarthritis pathogenesis. Int J Mol Sci 22(17):9208. https:\/\/doi.org\/10.3390\/ijms22179208","journal-title":"Int J Mol Sci"},{"key":"3984_CR51","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.sajb.2019.12.019","volume":"130","author":"S Murugesan","year":"2020","unstructured":"Murugesan S, Venkateswaran MR, Jayabal S, Periyasamy S (2020) Evaluation of the antioxidant and anti-arthritic potential of Zingiber officinale Rosc. by in vitro and in silico analysis. S Afr J Bot 130:45\u201353","journal-title":"S Afr J Bot"},{"key":"3984_CR52","doi-asserted-by":"publisher","first-page":"110517","DOI":"10.1016\/j.intimp.2023.110517","volume":"121","author":"S Nawaz","year":"2023","unstructured":"Nawaz S, Muhammad Irfan H, Alamgeer, Akram M, Jahan S (2023) Linalool: monoterpene alcohol effectiveness in chronic synovitis through lowering interleukin-17, spleen and thymus indices. Int Immunopharmacol 121:110517. https:\/\/doi.org\/10.1016\/j.intimp.2023.110517","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"3984_CR53","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1007\/s10787-023-01391-x","volume":"32","author":"N Nazar","year":"2024","unstructured":"Nazar N, Mehmood MH, Siddique R, Faisal MN (2024) Assessment of antiarthritic potential of Asparagus dumosus using formaldehyde and CFA-induced arthritic models in rats via modulation of oxidative stress biomarkers and mRNA expression of IL-1b, IL-6, RANKL, OPG, TNF-\u03b1 and COX-2. Inflammopharmacology 32(1):825\u2013847. https:\/\/doi.org\/10.1007\/s10787-023-01391-x","journal-title":"Inflammopharmacology"},{"issue":"1","key":"3984_CR54","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/j.1476-5381.1963.tb01508.x","volume":"21","author":"BB Newbould","year":"1963","unstructured":"Newbould BB (1963) Chemotherapy of arthritis induced in rats by mycobacterial adjuvant. Br J Pharmacol Chemother 21(1):127\u2013136. https:\/\/doi.org\/10.1111\/j.1476-5381.1963.tb01508.x","journal-title":"Br J Pharmacol Chemother"},{"key":"3984_CR55","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.biomaterials.2016.04.027","volume":"97","author":"C N\u00fa\u00f1ez","year":"2016","unstructured":"N\u00fa\u00f1ez C, Capelo JL, Igrejas G, Alfonso A, Botana LM, Lodeiro C (2016) An overview of the effective combination therapies for the treatment of breast cancer. Biomaterials 97:34\u201350. https:\/\/doi.org\/10.1016\/j.biomaterials.2016.04.027","journal-title":"Biomaterials"},{"key":"3984_CR56","doi-asserted-by":"publisher","first-page":"205031211987614","DOI":"10.1177\/2050312119876146","volume":"7","author":"MA Pab\u00f3n-Porras","year":"2019","unstructured":"Pab\u00f3n-Porras MA, Molina-R\u00edos S, Fl\u00f3rez-Su\u00e1rez JB, Coral-Alvarado PX, M\u00e9ndez-Patarroyo P, Quintana-L\u00f3pez G (2019) Rheumatoid arthritis and systemic lupus erythematosus: pathophysiological mechanisms related to innate immune system. SAGE Open Med 7:2050312119876146. https:\/\/doi.org\/10.1177\/2050312119876146","journal-title":"SAGE Open Med"},{"key":"3984_CR57","doi-asserted-by":"publisher","unstructured":"Pawar SS, Rohane SH (2021) Review on discovery studio: An important tool for molecular docking. https:\/\/doi.org\/10.5958\/0974-4150.2021.00014.6","DOI":"10.5958\/0974-4150.2021.00014.6"},{"issue":"8","key":"3984_CR58","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1078\/094471102321621322","volume":"9","author":"AT Peana","year":"2002","unstructured":"Peana AT, D\u2019Aquila PS, Panin F, Serra G, Pippia P, Moretti MD (2002) Anti-inflammatory activity of linalool and linalyl acetate constituents of essential oils. Phytomedicine 9(8):721\u2013726. https:\/\/doi.org\/10.1078\/094471102321621322","journal-title":"Phytomedicine"},{"issue":"1","key":"3984_CR59","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0014-2999(02)02856-X","volume":"460","author":"AT Peana","year":"2003","unstructured":"Peana AT, Paolo SD, Chessa ML, Moretti MD, Serra G, Pippia P (2003) (\u2212)-Linalool produces antinociception in two experimental models of pain. Eur J Pharmacol 460(1):37\u201341","journal-title":"Eur J Pharmacol"},{"issue":"18","key":"3984_CR60","doi-asserted-by":"publisher","first-page":"8227","DOI":"10.1039\/d1fo01078f","volume":"12","author":"S Prasad","year":"2021","unstructured":"Prasad S, Kulshreshtha A, Lall R, Gupta SC (2021) Inflammation and ROS in arthritis: management by Ayurvedic medicinal plants. Food Funct 12(18):8227\u20138247. https:\/\/doi.org\/10.1039\/d1fo01078f","journal-title":"Food Funct"},{"issue":"21","key":"3984_CR61","doi-asserted-by":"publisher","first-page":"5069","DOI":"10.3390\/molecules25215069","volume":"25","author":"MI Rodr\u00edguez-L\u00f3pez","year":"2020","unstructured":"Rodr\u00edguez-L\u00f3pez MI, Mercader-Ros MT, Lucas-Abell\u00e1n C, Pellicer JA, P\u00e9rez-Garrido A, P\u00e9rez-S\u00e1nchez H, Y\u00e1\u00f1ez-Gasc\u00f3n MJ, Gabald\u00f3n JA, N\u00fa\u00f1ez-Delicado E (2020) Comprehensive characterization of linalool-HP-\u03b2-cyclodextrin inclusion complexes. Molecules (Basel, Switzerland) 25(21):5069. https:\/\/doi.org\/10.3390\/molecules25215069","journal-title":"Molecules (Basel, Switzerland)"},{"issue":"1","key":"3984_CR62","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.emc.2021.09.003","volume":"40","author":"J Rose","year":"2022","unstructured":"Rose J (2022) Autoimmune connective tissue diseases: systemic lupus erythematosus and rheumatoid arthritis. Emerg Med Clin North Am 40(1):179\u2013191. https:\/\/doi.org\/10.1016\/j.emc.2021.09.003","journal-title":"Emerg Med Clin North Am"},{"issue":"2\u20133","key":"3984_CR63","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.pbiomolbio.2014.05.006","volume":"116","author":"S Salentin","year":"2014","unstructured":"Salentin S, Haupt VJ, Daminelli S, Schroeder M (2014) Polypharmacology rescored: protein-ligand interaction profiles for remote binding site similarity assessment. Prog Biophys Mol Biol 116(2\u20133):174\u2013186. https:\/\/doi.org\/10.1016\/j.pbiomolbio.2014.05.006","journal-title":"Prog Biophys Mol Biol"},{"issue":"5","key":"3984_CR64","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1080\/09546630410017275","volume":"15","author":"N Scheinfeld","year":"2004","unstructured":"Scheinfeld N (2004) A comprehensive review and evaluation of the side effects of the tumor necrosis factor alpha blockers etanercept, infliximab and adalimumab. J Dermatol Treat 15(5):280\u2013294. https:\/\/doi.org\/10.1080\/09546630410017275","journal-title":"J Dermatol Treat"},{"issue":"16","key":"3984_CR65","doi-asserted-by":"publisher","first-page":"6125","DOI":"10.3390\/molecules28166125","volume":"28","author":"A Sharma","year":"2023","unstructured":"Sharma A, Goel A, Lin Z (2023) In vitro and in silico anti-rheumatic arthritis activity of Nyctanthes arbor-tristis. Molecules (Basel, Switzerland) 28(16):6125. https:\/\/doi.org\/10.3390\/molecules28166125","journal-title":"Molecules (Basel, Switzerland)"},{"issue":"3","key":"3984_CR66","doi-asserted-by":"publisher","first-page":"666","DOI":"10.3390\/molecules26030666","volume":"26","author":"JB Sharmeen","year":"2021","unstructured":"Sharmeen JB, Mahomoodally FM, Zengin G, Maggi F (2021) Essential oils as natural sources of fragrance compounds for cosmetics and cosmeceuticals. Molecules (Basel, Switzerland) 26(3):666. https:\/\/doi.org\/10.3390\/molecules26030666","journal-title":"Molecules (Basel, Switzerland)"},{"issue":"9","key":"3984_CR67","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1093\/rheumatology\/keu159","volume":"53","author":"RJ Stack","year":"2014","unstructured":"Stack RJ, van Tuyl LH, Sloots M, van de Stadt LA, Hoogland W, Maat B, Mallen CD, Tiwana R, Raza K, van Schaardenburg D (2014) Symptom complexes in patients with seropositive arthralgia and in patients newly diagnosed with rheumatoid arthritis: a qualitative exploration of symptom development. Rheumatology (Oxford, England) 53(9):1646\u20131653. https:\/\/doi.org\/10.1093\/rheumatology\/keu159","journal-title":"Rheumatology (Oxford, England)"},{"issue":"2","key":"3984_CR68","doi-asserted-by":"publisher","first-page":"131","DOI":"10.7861\/clinmed.2021-0039","volume":"21","author":"FWD Tai","year":"2021","unstructured":"Tai FWD, McAlindon ME (2021) Non-steroidal anti-inflammatory drugs and the gastrointestinal tract. Clin Med (London, England) 21(2):131\u2013134. https:\/\/doi.org\/10.7861\/clinmed.2021-0039","journal-title":"Clin Med (London, England)"},{"issue":"12","key":"3984_CR69","doi-asserted-by":"publisher","first-page":"629","DOI":"10.3390\/md18120629","volume":"18","author":"J Tolosa","year":"2020","unstructured":"Tolosa J, Barba FJ, Pallar\u00e9s N, Ferrer E (2020) Mycotoxin identification and in silico toxicity assessment prediction in Atlantic salmon. Mar Drugs 18(12):629. https:\/\/doi.org\/10.3390\/md18120629","journal-title":"Mar Drugs"},{"key":"3984_CR70","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.20546\/ijcmas.2020.909.187","volume":"9","author":"RD Varia","year":"2020","unstructured":"Varia RD, Patel JH, Modi FD, Vihol PD, Bhavsar SK (2020) In vitro and in vivo antibacterial and anti-inflammatory properties of linalool. Int J Curr Microbiol Appl Sci 9:1481\u20131489","journal-title":"Int J Curr Microbiol Appl Sci"},{"key":"3984_CR71","doi-asserted-by":"publisher","unstructured":"Vinarov Z, Abdallah M, Agundez JAG, Allegaert K, Basit AW, Braeckmans M, Ceulemans J, Corsetti M, Griffin BT, Grimm M, Keszthelyi D, Koziolek M, Madla CM, Matthys C, McCoubrey LE, Mitra A, Reppas C, StappaertsJ, Steenackers N, Trevaskis NL, \u2026 Augustijns P (2021) Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: an UNGAP review. Eur J Pharm Sci 162:105812. https:\/\/doi.org\/10.1016\/j.ejps.2021.105812","DOI":"10.1016\/j.ejps.2021.105812"},{"issue":"11","key":"3984_CR72","doi-asserted-by":"publisher","first-page":"9647","DOI":"10.3390\/ijms24119647","volume":"24","author":"JL Wautier","year":"2023","unstructured":"Wautier JL, Wautier MP (2023) Pro- and anti-inflammatory prostaglandins and cytokines in humans: a mini review. Int J Mol Sci 24(11):9647. https:\/\/doi.org\/10.3390\/ijms24119647","journal-title":"Int J Mol Sci"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-03984-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-025-03984-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-03984-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T06:54:06Z","timestamp":1757141646000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-025-03984-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,7]]},"references-count":72,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["3984"],"URL":"https:\/\/doi.org\/10.1007\/s00210-025-03984-5","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,7]]},"assertion":[{"value":"12 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Animal Ethics Committee of Khulna University (KUAEC-2023-05-09).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}