{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:04:52Z","timestamp":1792073092376,"version":"4.4.0"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s00210-025-04093-z","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T15:51:17Z","timestamp":1743695477000},"page":"11493-11504","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Targeting therapy of PI3K\/AKT signaling pathway via non-coding RNAs in diabetic retinopathy"],"prefix":"10.1007","volume":"398","author":[{"given":"Shuai","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"4093_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119984","volume":"285","author":"M Akbarzadeh","year":"2021","unstructured":"Akbarzadeh M, Mihanfar A, Akbarzadeh S, Yousefi B, Majidinia M (2021) Crosstalk between miRNA and PI3K\/AKT\/mTOR signaling pathway in cancer. Life Sci 285:119984","journal-title":"Life Sci"},{"key":"4093_CR2","doi-asserted-by":"publisher","first-page":"159","DOI":"10.3390\/diabetology3010011","volume":"3","author":"P Ansari","year":"2022","unstructured":"Ansari P, Tabasumma N, Snigdha NN, Siam NH, Panduru RV, Azam S et al (2022) Diabetic retinopathy: an overview on mechanisms, pathophysiology and pharmacotherapy. Diabetology 3:159\u2013175","journal-title":"Diabetology"},{"key":"4093_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2021.112737","volume":"406","author":"A Bereimipour","year":"2021","unstructured":"Bereimipour A, Najafi H, Mirsane ES, Moradi S, Satarian L (2021) Roles of miR-204 in retinal development and maintenance. Exp Cell Res 406:112737","journal-title":"Exp Cell Res"},{"key":"4093_CR4","doi-asserted-by":"publisher","first-page":"2951","DOI":"10.3390\/biomedicines11112951","volume":"11","author":"M B\u0142aszkiewicz","year":"2023","unstructured":"B\u0142aszkiewicz M, Walulik A, Florek K, G\u00f3recki I, S\u0142awatyniec O, Gomu\u0142ka K (2023) Advances and perspectives in relation to the molecular basis of diabetic retinopathy\u2014a review. Biomedicines 11:2951","journal-title":"Biomedicines"},{"key":"4093_CR5","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.omtn.2021.01.035","volume":"24","author":"F Cai","year":"2021","unstructured":"Cai F, Jiang H, Li Y, Li Q, Yang C (2021) Upregulation of long non-coding RNA SNHG16 promotes diabetes-related RMEC dysfunction via activating NF-\u03baB and PI3K\/AKT pathways. Molecular Therapy-Nucleic Acids 24:512\u2013527","journal-title":"Molecular Therapy-Nucleic Acids"},{"key":"4093_CR6","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.2337\/db16-1246","volume":"66","author":"Q Chen","year":"2017","unstructured":"Chen Q, Qiu F, Zhou K, Matlock HG, Takahashi Y, Rajala RV et al (2017) Pathogenic role of microRNA-21 in diabetic retinopathy through downregulation of PPAR\u03b1. Diabetes 66:1671\u20131682","journal-title":"Diabetes"},{"key":"4093_CR7","doi-asserted-by":"publisher","first-page":"11872","DOI":"10.1080\/21655979.2021.2000721","volume":"12","author":"J Chen","year":"2021","unstructured":"Chen J, Liao L, Xu H, Zhang Z, Zhang J (2021) Long non-coding RNA MEG3 inhibits neovascularization in diabetic retinopathy by regulating microRNA miR-6720-5p and cytochrome B5 reductase 2. Bioengineered 12:11872\u201311884","journal-title":"Bioengineered"},{"key":"4093_CR8","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/s12967-022-03386-8","volume":"20","author":"R Du","year":"2022","unstructured":"Du R, Wu N, Bai Y, Tang L, Li L (2022) circMAP3K4 regulates insulin resistance in trophoblast cells during gestational diabetes mellitus by modulating the miR-6795-5p\/PTPN1 axis. J Transl Med 20:180","journal-title":"J Transl Med"},{"key":"4093_CR9","doi-asserted-by":"publisher","first-page":"168","DOI":"10.3389\/fncel.2013.00168","volume":"7","author":"C Ernst","year":"2013","unstructured":"Ernst C, Morton CC (2013) Identification and function of long non-coding RNA. Front Cell Neurosci 7:168","journal-title":"Front Cell Neurosci"},{"key":"4093_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.885650","volume":"13","author":"W Fan","year":"2022","unstructured":"Fan W, Pang H, Xie Z, Huang G, Zhou Z (2022) Circular RNAs in diabetes mellitus and its complications. Front Endocrinol 13:885650","journal-title":"Front Endocrinol"},{"key":"4093_CR11","doi-asserted-by":"publisher","first-page":"4311","DOI":"10.3892\/ol.2017.6695","volume":"14","author":"S Fang","year":"2017","unstructured":"Fang S, Ma X, Guo S, Lu J (2017) MicroRNA-126 inhibits cell viability and invasion in a diabetic retinopathy model via targeting IRS-1. Oncol Lett 14:4311\u20134318","journal-title":"Oncol Lett"},{"key":"4093_CR12","doi-asserted-by":"crossref","unstructured":"Gong Q, Su G (2017) Roles of miRNAs and long noncoding RNAs in the progression of diabetic retinopathy. Biosci Rep 37: BSR20171157","DOI":"10.1042\/BSR20171157"},{"key":"4093_CR13","doi-asserted-by":"publisher","first-page":"397","DOI":"10.2174\/1573399816666201103144231","volume":"17","author":"A Grover","year":"2021","unstructured":"Grover A, Sharma K, Gautam S, Gautam S, Gulati M, Singh SK (2021) Diabetes and its complications: therapies available, anticipated and aspired. Curr Diabetes Rev 17:397\u2013420","journal-title":"Curr Diabetes Rev"},{"key":"4093_CR14","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1159\/000479156","volume":"58","author":"Y Gu","year":"2017","unstructured":"Gu Y, Ke G, Wang L, Zhou E, Zhu K, Wei Y (2017) Altered expression profile of circular RNAs in the serum of patients with diabetic retinopathy revealed by microarray. Ophthalmic Res 58:176\u2013184","journal-title":"Ophthalmic Res"},{"key":"4093_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.833573","volume":"13","author":"H He","year":"2022","unstructured":"He H, Zhang J, Gong W, Liu M, Liu H, Li X et al (2022) Involvement of CircRNA expression profile in diabetic retinopathy and its potential diagnostic value. Front Genet 13:833573","journal-title":"Front Genet"},{"key":"4093_CR16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0310999","volume":"19","author":"Z Hosseinpoor","year":"2024","unstructured":"Hosseinpoor Z, Soheili Z-S, Davari M, Latifi-Navid H, Samiee S, Samiee D (2024) Crosstalk between MIR-96 and IRS\/PI3K\/AKT\/VEGF cascade in hRPE cells; A potential target for preventing diabetic retinopathy. PLoS ONE 19:e0310999","journal-title":"PLoS ONE"},{"key":"4093_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2022.106978","volume":"138","author":"A Ismail","year":"2023","unstructured":"Ismail A, El-Mahdy HA, Eldeib MG, Doghish AS (2023) miRNAs as cornerstones in diabetic microvascular complications. Mol Genet Metab 138:106978","journal-title":"Mol Genet Metab"},{"key":"4093_CR18","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/589813","volume":"2011","author":"JL Jacot","year":"2011","unstructured":"Jacot JL, Sherris D (2011) Potential therapeutic roles for inhibition of the PI3K\/Akt\/mTOR pathway in the pathophysiology of diabetic retinopathy. J Ophthalmol 2011:589813","journal-title":"J Ophthalmol"},{"key":"4093_CR19","doi-asserted-by":"crossref","unstructured":"Ji Z, Luo J, Su T, Chen C, Su Y0 (2021) miR-7a targets insulin receptor substrate-2 gene and suppresses viability and invasion of cells in diabetic retinopathy mice via PI3K-Akt-VEGF pathway. Diabetes Metab Syndr Obes 14:719\u2013728","DOI":"10.2147\/DMSO.S288482"},{"key":"4093_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2021.147399","volume":"1761","author":"H Khan","year":"2021","unstructured":"Khan H, Singh A, Thapa K, Garg N, Grewal AK, Singh TG (2021) Therapeutic modulation of the phosphatidylinositol 3-kinases (PI3K) pathway in cerebral ischemic injury. Brain Res 1761:147399","journal-title":"Brain Res"},{"key":"4093_CR21","first-page":"267","volume":"24","author":"VA Kordkheyli","year":"2021","unstructured":"Kordkheyli VA, Mishan MA, Tarsi AK, Mahrooz A, Kanavi MR, Hafezi-Moghadam A et al (2021) MicroRNAs may provide new strategies in the treatment and diagnosis of diabetic retinopathy: importance of VEGF. Iran J Basic Med Sci 24:267","journal-title":"Iran J Basic Med Sci"},{"key":"4093_CR22","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1016\/j.survophthal.2022.07.008","volume":"67","author":"E Kovoor","year":"2022","unstructured":"Kovoor E, Chauhan SK, Hajrasouliha A (2022) Role of inflammatory cells in pathophysiology and management of diabetic retinopathy. Surv Ophthalmol 67:1563\u20131573","journal-title":"Surv Ophthalmol"},{"key":"4093_CR23","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.915031","volume":"13","author":"RA Kowluru","year":"2022","unstructured":"Kowluru RA (2022) Long noncoding RNAs and mitochondrial homeostasis in the development of diabetic retinopathy. Front Endocrinol 13:915031","journal-title":"Front Endocrinol"},{"key":"4093_CR24","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s13167-023-00314-8","volume":"14","author":"M Kropp","year":"2023","unstructured":"Kropp M, Golubnitschaja O, Mazurakova A, Koklesova L, Sargheini N, Vo T-TKS et al (2023) Diabetic retinopathy as the leading cause of blindness and early predictor of cascading complications\u2014risks and mitigation. Epma Journal 14:21\u201342","journal-title":"Epma Journal"},{"key":"4093_CR25","doi-asserted-by":"publisher","first-page":"364","DOI":"10.4093\/dmj.2018.0182","volume":"42","author":"S Kusuhara","year":"2018","unstructured":"Kusuhara S, Fukushima Y, Ogura S, Inoue N, Uemura A (2018) Pathophysiology of diabetic retinopathy: the old and the new. Diabetes Metab J 42:364","journal-title":"Diabetes Metab J"},{"key":"4093_CR26","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1139\/cjpp-2020-0693","volume":"99","author":"X Li","year":"2021","unstructured":"Li X, Guo C, Chen Y, Yu F (2021) Long non-coding RNA SNHG16 regulates E2F1 expression by sponging miR-20a-5p and aggravating proliferative diabetic retinopathy. Can J Physiol Pharmacol 99:1207\u20131216","journal-title":"Can J Physiol Pharmacol"},{"key":"4093_CR27","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1038\/s41420-023-01717-2","volume":"9","author":"J Li","year":"2023","unstructured":"Li J, Chen K, Li X, Zhang X, Zhang L, Yang Q et al (2023a) Mechanistic insights into the alterations and regulation of the AKT signaling pathway in diabetic retinopathy. Cell Death Discovery 9:418","journal-title":"Cell Death Discovery"},{"key":"4093_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115694","volume":"168","author":"P Li","year":"2023","unstructured":"Li P, Huang D, Gu X (2023b) Exploring the dual role of circRNA and PI3K\/AKT pathway in tumors of the digestive system. Biomed Pharmacother 168:115694","journal-title":"Biomed Pharmacother"},{"key":"4093_CR29","doi-asserted-by":"crossref","unstructured":"Li B, Du Y-J, Xu F, Li H-B, Yang X (2024) Potential diagnostic markers of diabetic retinopathy: serum LncRNA MIAT, HOTTIP, SNHG16. Diabetes Metab Syndr Obes 17:4247\u20134256","DOI":"10.2147\/DMSO.S470755"},{"key":"4093_CR30","doi-asserted-by":"publisher","first-page":"e2688","DOI":"10.1210\/clinem\/dgab101","volume":"106","author":"Y-K Lu","year":"2021","unstructured":"Lu Y-K, Chu X, Wang S, Sun Y, Zhang J, Dong J et al (2021) Identification of circulating hsa_circ_0063425 and hsa_circ_0056891 as novel biomarkers for detection of type 2 diabetes. J Clin Endocrinol Metab 106:e2688\u2013e2699","journal-title":"J Clin Endocrinol Metab"},{"key":"4093_CR31","doi-asserted-by":"publisher","first-page":"8520489","DOI":"10.1155\/2024\/8520489","volume":"2024","author":"Y Luo","year":"2024","unstructured":"Luo Y, Li C (2024) Advances in research related to MicroRNA for diabetic retinopathy. J Diabetes Res 2024:8520489","journal-title":"J Diabetes Res"},{"key":"4093_CR32","doi-asserted-by":"crossref","unstructured":"Ma Y, Dong C, Chen X, Zhu R, Wang J (2021) Silencing of miR-20b-5p exerts inhibitory effect on diabetic retinopathy via inactivation of THBS1 gene induced VEGF\/Akt\/PI3K pathway. Diabetes Metab Syndr Obes 14:1183\u20131193","DOI":"10.2147\/DMSO.S299143"},{"key":"4093_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.123189","volume":"230","author":"SSA Mageed","year":"2023","unstructured":"Mageed SSA, Doghish AS, Ismail A, El-Husseiny AA, Fawzi SF, Mahmoud AM et al (2023) The role of miRNAs in insulin resistance and diabetic macrovascular complications\u2013a review. Int J Biol Macromol 230:123189","journal-title":"Int J Biol Macromol"},{"key":"4093_CR34","first-page":"2945","volume":"17","author":"X-B Mao","year":"2019","unstructured":"Mao X-B, Cheng Y-H, Xu Y-Y (2019) miR-204-5p promotes diabetic retinopathy development via downregulation of microtubule-associated protein 1 light chain 3. Exp Ther Med 17:2945\u20132952","journal-title":"Exp Ther Med"},{"key":"4093_CR35","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/s41580-022-00566-8","volume":"24","author":"JS Mattick","year":"2023","unstructured":"Mattick JS, Amaral PP, Carninci P, Carpenter S, Chang HY, Chen L-L et al (2023) Long non-coding RNAs: definitions, functions, challenges and recommendations. Nat Rev Mol Cell Biol 24:430\u2013447","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4093_CR36","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/s41576-023-00662-1","volume":"25","author":"K Nemeth","year":"2024","unstructured":"Nemeth K, Bayraktar R, Ferracin M, Calin GA (2024) Non-coding RNAs in disease: from mechanisms to therapeutics. Nat Rev Genet 25:211\u2013232","journal-title":"Nat Rev Genet"},{"key":"4093_CR37","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1038\/s41592-022-01487-2","volume":"19","author":"AF Nielsen","year":"2022","unstructured":"Nielsen AF, Bindereif A, Bozzoni I, Hanan M, Hansen TB, Irimia M et al (2022) Best practice standards for circular RNA research. Nat Methods 19:1208\u20131220","journal-title":"Nat Methods"},{"key":"4093_CR38","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.935244","volume":"13","author":"S-R Niu","year":"2022","unstructured":"Niu S-R, Hu J-M, Lin S, Hong Y (2022) Research progress on exosomes\/microRNAs in the treatment of diabetic retinopathy. Front Endocrinol 13:935244","journal-title":"Front Endocrinol"},{"key":"4093_CR39","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1530\/EC-19-0446","volume":"8","author":"ER Polina","year":"2019","unstructured":"Polina ER, Oliveira FM, Sbruzzi RC, Crispim D, Canani LH, Santos KGD (2019) Gene polymorphism and plasma levels of miR-155 in diabetic retinopathy. Endocr Connect 8:1591\u20131599","journal-title":"Endocr Connect"},{"key":"4093_CR40","doi-asserted-by":"publisher","first-page":"11088","DOI":"10.3390\/ijms222011088","volume":"22","author":"T Pungsrinont","year":"2021","unstructured":"Pungsrinont T, Kallenbach J, Baniahmad A (2021) Role of PI3K-AKT-mTOR pathway as a pro-survival signaling and resistance-mediating mechanism to therapy of prostate cancer. Int J Mol Sci 22:11088","journal-title":"Int J Mol Sci"},{"key":"4093_CR41","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/920280","volume":"2015","author":"D Qin","year":"2015","unstructured":"Qin D, Zhang G-M, Xu X, Wang L-Y (2015) The PI3K\/Akt signaling pathway mediates the high glucose-induced expression of extracellular matrix molecules in human retinal pigment epithelial cells. J Diabetes Res 2015:920280","journal-title":"J Diabetes Res"},{"key":"4093_CR42","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.bbrc.2016.01.164","volume":"471","author":"G-Z Qiu","year":"2016","unstructured":"Qiu G-Z, Tian W, Fu H-T, Li C-P, Liu B (2016) Long noncoding RNA-MEG3 is involved in diabetes mellitus-related microvascular dysfunction. Biochem Biophys Res Commun 471:135\u2013141","journal-title":"Biochem Biophys Res Commun"},{"key":"4093_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbior.2019.100657","volume":"75","author":"MK Rathinaswamy","year":"2020","unstructured":"Rathinaswamy MK, Burke JE (2020) Class I phosphoinositide 3-kinase (PI3K) regulatory subunits and their roles in signaling and disease. Adv Biol Regul 75:100657","journal-title":"Adv Biol Regul"},{"key":"4093_CR44","doi-asserted-by":"publisher","first-page":"5857","DOI":"10.1073\/pnas.0909570107","volume":"107","author":"H Ren","year":"2010","unstructured":"Ren H, Accili D, Duan C (2010) Hypoxia converts the myogenic action of insulin-like growth factors into mitogenic action by differentially regulating multiple signaling pathways. Proc Natl Acad Sci 107:5857\u20135862","journal-title":"Proc Natl Acad Sci"},{"key":"4093_CR45","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.tig.2016.03.002","volume":"32","author":"J Salzman","year":"2016","unstructured":"Salzman J (2016) Circular RNA expression: its potential regulation and function. Trends Genet 32:309\u2013316","journal-title":"Trends Genet"},{"key":"4093_CR46","doi-asserted-by":"publisher","first-page":"6649222","DOI":"10.1155\/2021\/6649222","volume":"2021","author":"R Sanguineti","year":"2021","unstructured":"Sanguineti R, Puddu A, Nicol\u00f2 M, Traverso CE, Cordera R, Viviani GL et al (2021) miR-126 mimic counteracts the increased secretion of VEGF-A induced by high glucose in ARPE-19 cells. J Diabetes Res 2021:6649222","journal-title":"J Diabetes Res"},{"key":"4093_CR47","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.ebiom.2016.09.017","volume":"12","author":"MY Shah","year":"2016","unstructured":"Shah MY, Ferrajoli A, Sood AK, Lopez-Berestein G, Calin GA (2016) microRNA therapeutics in cancer\u2014an emerging concept. EBioMedicine 12:34\u201342","journal-title":"EBioMedicine"},{"key":"4093_CR48","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1080\/13813455.2023.2243651","volume":"130","author":"H Singh","year":"2024","unstructured":"Singh H, Singh R, Singh A, Singh H, Singh G, Kaur S et al (2024) Role of oxidative stress in diabetes-induced complications and their management with antioxidants. Arch Physiol Biochem 130:616\u2013641","journal-title":"Arch Physiol Biochem"},{"key":"4093_CR49","doi-asserted-by":"crossref","unstructured":"Smit-Mcbride Z, Morse LS (2021) MicroRNA and diabetic retinopathy\u2014biomarkers and novel therapeutics. Annals of translational medicine, 9","DOI":"10.21037\/atm-20-5189"},{"key":"4093_CR50","doi-asserted-by":"publisher","first-page":"4867","DOI":"10.1167\/iovs.10-5881","volume":"51","author":"AW Stitt","year":"2010","unstructured":"Stitt AW (2010) AGEs and diabetic retinopathy. Invest Ophthalmol vis Sci 51:4867\u20134874","journal-title":"Invest Ophthalmol vis Sci"},{"key":"4093_CR51","doi-asserted-by":"crossref","unstructured":"Subramanian S, Steer CJ (2019) MicroRNA regulation in health and disease. MDPI","DOI":"10.3390\/genes10060457"},{"key":"4093_CR52","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/343560","volume":"2013","author":"JM Tarr","year":"2013","unstructured":"Tarr JM, Kaul K, Chopra M, Kohner EM, Chibber R (2013) Pathophysiology of diabetic retinopathy. ISRN Ophthalmol 2013:343560","journal-title":"ISRN Ophthalmol"},{"key":"4093_CR53","doi-asserted-by":"publisher","first-page":"H1744","DOI":"10.1152\/ajpheart.01088.2004","volume":"289","author":"S Varma","year":"2005","unstructured":"Varma S, Lal BK, Zheng R, Breslin JW, Saito S, Pappas PJ et al (2005) Hyperglycemia alters PI3k and Akt signaling and leads to endothelial cell proliferative dysfunction. Am J Physiol-Heart Circ Physiol 289:H1744\u2013H1751","journal-title":"Am J Physiol-Heart Circ Physiol"},{"key":"4093_CR54","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.3390\/biom12121774","volume":"12","author":"M Wang","year":"2022","unstructured":"Wang M, Li Q, Jin M, Wang Z, Zhang X, Sun X et al (2022) Noncoding RNAs are promising therapeutic targets for diabetic retinopathy: an updated review (2017\u20132022). Biomolecules 12:1774","journal-title":"Biomolecules"},{"key":"4093_CR55","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1038\/s41392-021-00788-w","volume":"6","author":"C Xue","year":"2021","unstructured":"Xue C, Li G, Lu J, Li L (2021) Crosstalk between circRNAs and the PI3K\/AKT signaling pathway in cancer progression. Signal Transduct Target Ther 6:400","journal-title":"Signal Transduct Target Ther"},{"key":"4093_CR56","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2020-001446","volume":"8","author":"F Yu","year":"2020","unstructured":"Yu F, Chapman S, Pham DL, Ko ML, Zhou B, Ko GY (2020) Decreased miR-150 in obesity-associated type 2 diabetic mice increases intraocular inflammation and exacerbates retinal dysfunction. BMJ Open Diabetes Res Care 8:e001446","journal-title":"BMJ Open Diabetes Res Care"},{"key":"4093_CR57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/mmr.2023.13081","volume":"28","author":"L Yuan","year":"2023","unstructured":"Yuan L, Duan J, Zhou H (2023) Perspectives of circular RNAs in diabetic complications from biological markers to potential therapeutic targets. Mol Med Rep 28:1\u201312","journal-title":"Mol Med Rep"},{"key":"4093_CR58","doi-asserted-by":"publisher","first-page":"659","DOI":"10.3390\/cells9030659","volume":"9","author":"M Zaiou","year":"2020","unstructured":"Zaiou M (2020) circRNAs signature as potential diagnostic and prognostic biomarker for diabetes mellitus and related cardiovascular complications. Cells 9:659","journal-title":"Cells"},{"key":"4093_CR59","first-page":"509","volume":"34","author":"X Zhang","year":"2020","unstructured":"Zhang X, Liu Z (2020) MiR-19a inhibitor improves diabetic retinopathy in rats through PTEN\/Akt\/P-Akt signaling pathway. J Biol Regul Homeost Agents 34:509\u2013515","journal-title":"J Biol Regul Homeost Agents"},{"key":"4093_CR60","doi-asserted-by":"publisher","first-page":"E1050","DOI":"10.1152\/ajpendo.00444.2018","volume":"316","author":"Z-Z Zhang","year":"2019","unstructured":"Zhang Z-Z, Qin X-H, Zhang J (2019) MicroRNA-183 inhibition exerts suppressive effects on diabetic retinopathy by inactivating BTG1-mediated PI3K\/Akt\/VEGF signaling pathway. Am J Physiol-Endocrinol Metab 316:E1050\u2013E1060","journal-title":"Am J Physiol-Endocrinol Metab"},{"key":"4093_CR61","first-page":"2022","volume":"12","author":"C Zhao","year":"2019","unstructured":"Zhao C, Fei X, Xu B, Lu Y, Zhang Q (2019) Long non-coding RNA HEIH contributes to diabetic retinopathy by regulating miR-939\/VEGF axis. Int J Clin Exp Pathol 12:2022","journal-title":"Int J Clin Exp Pathol"},{"key":"4093_CR62","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3892\/ijmm.2020.4775","volume":"47","author":"Y Zheng","year":"2021","unstructured":"Zheng Y, Liu Y, Wang L, Xu H, Lu Z, Xuan Y et al (2021) MicroRNA-126 suppresses the proliferation and migration of endothelial cells in experimental diabetic retinopathy by targeting polo-like kinase 4. Int J Mol Med 47:151\u2013160","journal-title":"Int J Mol Med"},{"key":"4093_CR63","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1080\/10799893.2020.1783556","volume":"41","author":"L Zhou","year":"2021","unstructured":"Zhou L, Zhang S, Zhang L, Li F, Sun H, Feng J (2021) MiR-199a-3p inhibits the proliferation, migration, and invasion of endothelial cells and retinal pericytes of diabetic retinopathy rats through regulating FGF7 via EGFR\/PI3K\/AKT pathway. J Recept Sig Transduct 41:19\u201331","journal-title":"J Recept Sig Transduct"},{"key":"4093_CR64","first-page":"1173","volume":"21","author":"Z Zhuang","year":"2015","unstructured":"Zhuang Z, Hu H, Tian S-Y, Lu Z-J, Zhang T-Z, Bai Y-L (2015) Down-regulation of microRNA-155 attenuates retinal neovascularization via the PI3K\/Akt pathway. Mol vis 21:1173","journal-title":"Mol vis"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04093-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-025-04093-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04093-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T06:03:03Z","timestamp":1758261783000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-025-04093-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,1]]},"references-count":64,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["4093"],"URL":"https:\/\/doi.org\/10.1007\/s00210-025-04093-z","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,1]]},"assertion":[{"value":"19 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"It is not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"It is not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human ethics"}},{"value":"It is not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}