{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T05:44:07Z","timestamp":1758347047134,"version":"3.44.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473910, 82274016, 82273925, 82473915, 82003746","82473910, 82274016, 82273925, 82473915, 82003746","82473910, 82274016, 82273925, 82473915, 82003746","82473910, 82274016, 82273925, 82473915, 82003746","82473910, 82274016, 82273925, 82473915, 82003746","82473910, 82274016, 82273925, 82473915, 82003746"],"award-info":[{"award-number":["82473910, 82274016, 82273925, 82473915, 82003746","82473910, 82274016, 82273925, 82473915, 82003746","82473910, 82274016, 82273925, 82473915, 82003746","82473910, 82274016, 82273925, 82473915, 82003746","82473910, 82274016, 82273925, 82473915, 82003746","82473910, 82274016, 82273925, 82473915, 82003746"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515011133, 2022A1515011374, 2021A1515220031","2023A1515011133, 2022A1515011374, 2021A1515220031","2023A1515011133, 2022A1515011374, 2021A1515220031","2023A1515011133, 2022A1515011374, 2021A1515220031","2023A1515011133, 2022A1515011374, 2021A1515220031","2023A1515011133, 2022A1515011374, 2021A1515220031"],"award-info":[{"award-number":["2023A1515011133, 2022A1515011374, 2021A1515220031","2023A1515011133, 2022A1515011374, 2021A1515220031","2023A1515011133, 2022A1515011374, 2021A1515220031","2023A1515011133, 2022A1515011374, 2021A1515220031","2023A1515011133, 2022A1515011374, 2021A1515220031","2023A1515011133, 2022A1515011374, 2021A1515220031"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangzhou Science and Technology Program Project","award":["2023A04J0542, 2023B03J1251","2023A04J0542, 2023B03J1251","2023A04J0542, 2023B03J1251","2023A04J0542, 2023B03J1251","2023A04J0542, 2023B03J1251","2023A04J0542, 2023B03J1251"],"award-info":[{"award-number":["2023A04J0542, 2023B03J1251","2023A04J0542, 2023B03J1251","2023A04J0542, 2023B03J1251","2023A04J0542, 2023B03J1251","2023A04J0542, 2023B03J1251","2023A04J0542, 2023B03J1251"]}]},{"DOI":"10.13039\/501100010883","name":"Administration of Traditional Chinese Medicine of Guangdong Province","doi-asserted-by":"crossref","award":["20241001","20241001","20241001","20241001","20241001","20241001"],"award-info":[{"award-number":["20241001","20241001","20241001","20241001","20241001","20241001"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["A2023021","A2023021","A2023021","A2023021","A2023021","A2023021"],"award-info":[{"award-number":["A2023021","A2023021","A2023021","A2023021","A2023021","A2023021"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s00210-025-04110-1","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T03:27:47Z","timestamp":1744082867000},"page":"12615-12632","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Levo-corydalmine derived from Rhizoma Corydalis suppresses Ox-LDL-induced endothelial cell activation and improves vasodilatation by regulating the DDIT3-eNOS pathway"],"prefix":"10.1007","volume":"398","author":[{"given":"Shaoxia","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuoming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenwei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilong","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihua","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"4110_CR1","doi-asserted-by":"publisher","first-page":"6093","DOI":"10.3390\/ijms20236093","volume":"20","author":"H Cao","year":"2019","unstructured":"Cao H, Jia Q, Yan L, Chen C, Xing S, Shen D (2019) Quercetin suppresses the progression of atherosclerosis by regulating MST1-mediated autophagy in ox-LDL-induced RAW264.7 macrophage foam cells. Int J Mol Sci 20:6093","journal-title":"Int J Mol Sci"},{"key":"4110_CR2","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1002\/ijc.30780","volume":"141","author":"WL Dai","year":"2017","unstructured":"Dai WL, Yan B, Jiang N, Wu JJ, Liu XF, Liu JH, Yu BY (2017) Simultaneous inhibition of NMDA and mGlu1\/5 receptors by levo-corydalmine in rat spinal cord attenuates bone cancer pain. Int J Cancer 141:805\u2013815","journal-title":"Int J Cancer"},{"key":"4110_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-018-0175-1","volume":"50","author":"WL Dai","year":"2018","unstructured":"Dai WL, Liu XT, Bao YN, Yan B, Jiang N, Yu BY, Liu JH (2018) Selective blockade of spinal D2DR by levo-corydalmine attenuates morphine tolerance via suppressing PI3K\/Akt-MAPK signaling in a MOR-dependent manner. Exp Mol Med 50:1\u201312","journal-title":"Exp Mol Med"},{"key":"4110_CR4","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s12964-020-00556-3","volume":"18","author":"WL Dai","year":"2020","unstructured":"Dai WL, Yan B, Bao YN, Fan JF, Liu JH (2020) Suppression of peripheral NGF attenuates neuropathic pain induced by chronic constriction injury through the TAK1-MAPK\/NF-\u03baB signaling pathways. Cell Commun Signal 18:66","journal-title":"Cell Commun Signal"},{"key":"4110_CR5","doi-asserted-by":"publisher","first-page":"115511","DOI":"10.1016\/j.biopha.2023.115511","volume":"167","author":"JH Feng","year":"2023","unstructured":"Feng JH, Chen K, Shen SY, Luo YF, Liu XH, Chen X, Gao W, Tong YR (2023) The composition, pharmacological effects, related mechanisms and drug delivery of alkaloids from Corydalis yanhusuo. Biomed Pharmacother 167:115511","journal-title":"Biomed Pharmacother"},{"issue":"829\u2013837","key":"4110_CR6","first-page":"837a","volume":"33","author":"U F\u00f6rstermann","year":"2012","unstructured":"F\u00f6rstermann U, Sessa WC (2012) Nitric oxide synthases: regulation and function. Eur Heart J 33(829\u2013837):837a\u2013837d","journal-title":"Eur Heart J"},{"key":"4110_CR7","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1161\/CIRCRESAHA.115.306301","volume":"118","author":"MA Gimbrone Jr","year":"2016","unstructured":"Gimbrone MA Jr, Garc\u00eda-Carde\u00f1a G (2016) Endothelial cell dysfunction and the pathobiology of atherosclerosis. Circ Res 118:620\u2013636","journal-title":"Circ Res"},{"key":"4110_CR8","doi-asserted-by":"publisher","first-page":"3905","DOI":"10.1038\/srep03905","volume":"4","author":"Z Guo","year":"2014","unstructured":"Guo Z, Man Y, Wang X, Jin H, Sun X, Su X, Hao J, Mi W (2014) Levo-tetrahydropalmatine attenuates oxaliplatin-induced mechanical hyperalgesia in mice. Sci Rep 4:3905","journal-title":"Sci Rep"},{"key":"4110_CR9","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.jacbts.2018.01.015","volume":"3","author":"L Heikal","year":"2018","unstructured":"Heikal L, Starr A, Hussein D, Prieto-Lloret J, Aaronson P, Dailey LA, Nandi M (2018) l-Phenylalanine restores vascular function in spontaneously hypertensive rats through activation of the GCH1-GFRP complex. JACC Basic Transl Sci 3:366\u2013377","journal-title":"JACC Basic Transl Sci"},{"key":"4110_CR10","doi-asserted-by":"publisher","first-page":"e83922","DOI":"10.1371\/journal.pone.0083922","volume":"8","author":"KY Hsin","year":"2013","unstructured":"Hsin KY, Ghosh S, Kitano H (2013) Combining machine learning systems and multiple docking simulation packages to improve docking prediction reliability for network pharmacology. PLoS ONE 8:e83922","journal-title":"PLoS ONE"},{"key":"4110_CR11","doi-asserted-by":"publisher","first-page":"937","DOI":"10.3390\/molecules22060937","volume":"22","author":"Y Hu","year":"2017","unstructured":"Hu Y, Kodithuwakku ND, Zhou L, Li C, Han D, Fang W, Liu J, Li Y (2017) Levo-corydalmine alleviates neuropathic cancer pain induced by tumor compression via the CCL2\/CCR2 pathway. Molecules (Basel, Switzerland) 22:937","journal-title":"Molecules (Basel, Switzerland)"},{"key":"4110_CR12","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1093\/bib\/bbt035","volume":"15","author":"C Huang","year":"2014","unstructured":"Huang C, Zheng C, Li Y, Wang Y, Lu A, Yang L (2014) Systems pharmacology in drug discovery and therapeutic insight for herbal medicines. Brief Bioinform 15:710\u2013733","journal-title":"Brief Bioinform"},{"key":"4110_CR13","doi-asserted-by":"publisher","first-page":"106142","DOI":"10.1016\/j.biocel.2021.106142","volume":"143","author":"X Jing","year":"2022","unstructured":"Jing X, Sun W, Yang X, Huang H, Wang P, Luo Q, Xia S, Fang C, Zhang Q, Guo J, Xu Z (2022) CCAAT\/enhancer-binding protein (C\/EBP) homologous protein promotes alveolar epithelial cell senescence via the nuclear factor-kappa B pathway in pulmonary fibrosis. Int J Biochem Cell Biol 143:106142","journal-title":"Int J Biochem Cell Biol"},{"key":"4110_CR14","doi-asserted-by":"crossref","unstructured":"Kim J, Brunetti B, Kumar A, Mangla A, Honda K, Yoshida A (2024) Inhibition of glutaminase elicits senolysis in therapy-induced senescent melanoma cells. bioRxiv: 2024.2009.2012.612728","DOI":"10.1101\/2024.09.12.612728"},{"key":"4110_CR15","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1161\/CIRCULATIONAHA.124.070087","volume":"150","author":"P Libby","year":"2024","unstructured":"Libby P (2024) Pathogenesis of atherothrombotic events: from lumen to lesion and beyond. Circulation 150:1217\u20131219","journal-title":"Circulation"},{"key":"4110_CR16","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s41572-019-0106-z","volume":"5","author":"P Libby","year":"2019","unstructured":"Libby P, Buring JE, Badimon L, Hansson GK, Deanfield J, Bittencourt MS, Tokg\u00f6zo\u011flu L, Lewis EF (2019) Atherosclerosis. Nat Rev Dis Primers 5:56","journal-title":"Nat Rev Dis Primers"},{"key":"4110_CR17","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.phrs.2008.12.001","volume":"59","author":"H-T Liu","year":"2009","unstructured":"Liu H-T, Li W-M, Xu G, Li X-Y, Bai X-F, Wei P, Yu C, Du Y-G (2009) Chitosan oligosaccharides attenuate hydrogen peroxide-induced stress injury in human umbilical vein endothelial cells. Pharmacol Res 59:167\u2013175","journal-title":"Pharmacol Res"},{"key":"4110_CR18","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1161\/CIRCULATIONAHA.111.041830","volume":"125","author":"C Loinard","year":"2012","unstructured":"Loinard C, Zouggari Y, Rueda P, Ramkhelawon B, Cochain C, Vilar J, R\u00e9calde A, Richart A, Charue D, Duriez M, Mori M, Arenzana-Seisdedos F, L\u00e9vy BI, Heymes C, Silvestre J-S (2012) C\/EBP homologous protein-10 (CHOP-10) limits postnatal neovascularization through control of endothelial nitric oxide synthase gene expression. Circulation 125:1014\u20131026","journal-title":"Circulation"},{"key":"4110_CR19","doi-asserted-by":"publisher","first-page":"109314","DOI":"10.1016\/j.jnutbio.2023.109314","volume":"116","author":"G Luo","year":"2023","unstructured":"Luo G, Xiang L, Xiao L (2023) Quercetin alleviates atherosclerosis by suppressing oxidized LDL-induced senescence in plaque macrophage via inhibiting the p38MAPK\/p16 pathway. J Nutr Biochem 116:109314","journal-title":"J Nutr Biochem"},{"key":"4110_CR20","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.7150\/jca.91129","volume":"15","author":"XN Ma","year":"2024","unstructured":"Ma XN, Yao CH, Yang YJ, Li X, Zhou MY, Yang J, Zhang S, Yu BY, Dai WL, Liu JH (2024) Blockade of spinal dopamine D1\/D2 receptor heteromers by levo-corydalmine suppressed calcium signaling cascade in spinal neurons to alleviate bone cancer pain in rats. J Cancer 15:1041\u20131052","journal-title":"J Cancer"},{"key":"4110_CR21","doi-asserted-by":"publisher","first-page":"S56","DOI":"10.1164\/ajrccm.162.supplement_1.maic-15","volume":"162","author":"FD Martinez","year":"2000","unstructured":"Martinez FD (2000) Context dependency of markers of disease. Am J Respir Crit Care Med 162:S56\u2013S57","journal-title":"Am J Respir Crit Care Med"},{"key":"4110_CR22","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.ajpath.2022.09.004","volume":"193","author":"L Mastrogiacomo","year":"2023","unstructured":"Mastrogiacomo L, Ballagh R, Venegas-Pino DE, Kaur H, Shi P, Werstuck GH (2023) The effects of hyperglycemia on early endothelial activation and the initiation of atherosclerosis. Am J Pathol 193:121\u2013133","journal-title":"Am J Pathol"},{"key":"4110_CR23","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.tem.2016.11.002","volume":"28","author":"YI Miller","year":"2017","unstructured":"Miller YI, Shyy JYJ (2017) Context-dependent role of oxidized lipids and lipoproteins in inflammation. Trends Endocrinol Metab 28:143\u2013152","journal-title":"Trends Endocrinol Metab"},{"key":"4110_CR24","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1093\/cvr\/cvz338","volume":"116","author":"C Mineo","year":"2020","unstructured":"Mineo C (2020) Lipoprotein receptor signalling in atherosclerosis. Cardiovasc Res 116:1254\u20131274","journal-title":"Cardiovasc Res"},{"key":"4110_CR25","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s10456-018-9613-x","volume":"21","author":"P Nowak-Sliwinska","year":"2018","unstructured":"Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, B\u00f6ck BC, Brooks PC, Bussolino F, Cakir B, Carmeliet P, Castranova D, Cimpean AM, Cleaver O, Coukos G, Davis GE, De Palma M, Dimberg A, Dings RPM, Djonov V, Dudley AC, Dufton NP, Fendt S-M, Ferrara N, Fruttiger M, Fukumura D, Ghesqui\u00e8re B, Gong Y, Griffin RJ, Harris AL, Hughes CCW, Hultgren NW, Iruela-Arispe ML, Irving M, Jain RK, Kalluri R, Kalucka J, Kerbel RS, Kitajewski J, Klaassen I, Kleinmann HK, Koolwijk P, Kuczynski E, Kwak BR, Marien K, Melero-Martin JM, Munn LL, Nicosia RF, Noel A, Nurro J, Olsson A-K, Petrova TV, Pietras K, Pili R, Pollard JW, Post MJ, Quax PHA, Rabinovich GA, Raica M, Randi AM, Ribatti D, Ruegg C, Schlingemann RO, Schulte-Merker S, Smith LEH, Song JW, Stacker SA, Stalin J, Stratman AN, Van de Velde M, van Hinsbergh VWM, Vermeulen PB, Waltenberger J, Weinstein BM, Xin H, Yetkin-Arik B, Yla-Herttuala S, Yoder MC, Griffioen AW (2018) Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis 21:425\u2013532","journal-title":"Angiogenesis"},{"key":"4110_CR26","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/S1053-2498(02)00494-1","volume":"22","author":"LP Perrault","year":"2003","unstructured":"Perrault LP, Malo O, Bidouard JP, Villeneuve N, Vilaine JP, Vanhoutte PM (2003) Inhibiting the NO pathway with intracoronary L-NAME infusion increases endothelial dysfunction and intimal hyperplasia after heart transplantation. J Heart Lung Transplant 22:439\u2013451","journal-title":"J Heart Lung Transplant"},{"key":"4110_CR27","doi-asserted-by":"publisher","first-page":"11324","DOI":"10.3390\/ijms150711324","volume":"15","author":"CM Steyers 3rd","year":"2014","unstructured":"Steyers CM 3rd, Miller FJ Jr (2014) Endothelial dysfunction in chronic inflammatory diseases. Int J Mol Sci 15:11324\u201311349","journal-title":"Int J Mol Sci"},{"key":"4110_CR28","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","volume":"51","author":"D Szklarczyk","year":"2023","unstructured":"Szklarczyk D, Kirsch R, Koutrouli M, Nastou K, Mehryary F, Hachilif R, Gable AL, Fang T, Doncheva NT, Pyysalo S, Bork P, Jensen LJ, von Mering C (2023) The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res 51:D638\u2013D646","journal-title":"Nucleic Acids Res"},{"key":"4110_CR29","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1080\/13880209.2020.1741651","volume":"58","author":"B Tian","year":"2020","unstructured":"Tian B, Tian M, Huang SM (2020) Advances in phytochemical and modern pharmacological research of Rhizoma Corydalis. Pharm Biol 58:265\u2013275","journal-title":"Pharm Biol"},{"key":"4110_CR30","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1093\/cvr\/cvp078","volume":"82","author":"Y Wang","year":"2009","unstructured":"Wang Y, Huang Y, Lam KSL, Li Y, Wong WT, Ye H, Lau C-W, Vanhoutte PM, Xu A (2009) Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase. Cardiovasc Res 82:484\u2013492","journal-title":"Cardiovasc Res"},{"key":"4110_CR31","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1038\/s41401-021-00769-3","volume":"43","author":"B Wen","year":"2022","unstructured":"Wen B, Dang Y-Y, Wu S-H, Huang Y-M, Ma K-Y, Xu Y-M, Zheng X-L, Dai X-Y (2022) Antiatherosclerotic effect of dehydrocorydaline on ApoE-\/- mice: inhibition of macrophage inflammation. Acta Pharmacol Sin 43:1408\u20131418","journal-title":"Acta Pharmacol Sin"},{"key":"4110_CR32","doi-asserted-by":"publisher","first-page":"D1074","DOI":"10.1093\/nar\/gkx1037","volume":"46","author":"DS Wishart","year":"2018","unstructured":"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M (2018) DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res 46:D1074\u2013D1082","journal-title":"Nucleic Acids Res"},{"key":"4110_CR33","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.tibs.2011.03.001","volume":"36","author":"U Woehlbier","year":"2011","unstructured":"Woehlbier U, Hetz C (2011) Modulating stress responses by the UPRosome: a matter of life and death. Trends Biochem Sci 36:329\u2013337","journal-title":"Trends Biochem Sci"},{"key":"4110_CR34","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1124\/pharmrev.120.000096","volume":"73","author":"S Xu","year":"2021","unstructured":"Xu S, Ilyas I, Little PJ, Li H, Kamato D, Zheng X, Luo S, Li Z, Liu P, Han J, Harding IC, Ebong EE, Cameron SJ, Stewart AG, Weng J (2021) Endothelial dysfunction in atherosclerotic cardiovascular diseases and beyond: from mechanism to pharmacotherapies. Pharmacol Rev 73:924\u2013967","journal-title":"Pharmacol Rev"},{"key":"4110_CR35","doi-asserted-by":"publisher","first-page":"73","DOI":"10.31083\/j.rcm2302073","volume":"23","author":"J Zhang","year":"2022","unstructured":"Zhang J (2022) Biomarkers of endothelial activation and dysfunction in cardiovascular diseases. Rev Cardiovasc Med 23:73","journal-title":"Rev Cardiovasc Med"},{"key":"4110_CR36","doi-asserted-by":"publisher","first-page":"e47030","DOI":"10.1371\/journal.pone.0047030","volume":"7","author":"D-M Zhang","year":"2012","unstructured":"Zhang D-M, Li Y, Cheang WS, Lau CW, Lin S-M, Zhang Q-L, Yao N, Wang Y, Wu X, Huang Y, Ye W-C (2012) Cajaninstilbene acid relaxes rat renal arteries: roles of Ca2+ antagonism and protein kinase C-dependent mechanism. PLoS ONE 7:e47030","journal-title":"PLoS ONE"},{"key":"4110_CR37","doi-asserted-by":"publisher","first-page":"3113","DOI":"10.1080\/13880209.2016.1211714","volume":"54","author":"Q Zhang","year":"2016","unstructured":"Zhang Q, Chen C, Wang FQ, Li CH, Zhang QH, Hu YJ, Xia ZN, Yang FQ (2016) Simultaneous screening and analysis of antiplatelet aggregation active alkaloids from Rhizoma Corydalis. Pharm Biol 54:3113\u20133120","journal-title":"Pharm Biol"},{"key":"4110_CR38","doi-asserted-by":"publisher","first-page":"116820","DOI":"10.1016\/j.lfs.2019.116820","volume":"235","author":"W Zhang","year":"2019","unstructured":"Zhang W, Xue K, Gao Y, Huai Y, Wang W, Miao Z, Dang K, Jiang S, Qian A (2019) Systems pharmacology dissection of action mechanisms of Dipsaci Radix for osteoporosis. Life Sci 235:116820","journal-title":"Life Sci"},{"key":"4110_CR39","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.neuropharm.2018.03.004","volume":"135","author":"L Zhou","year":"2018","unstructured":"Zhou L, Hu Y, Li C, Yan Y, Ao L, Yu B, Fang W, Liu J, Li Y (2018) Levo-corydalmine alleviates vincristine-induced neuropathic pain in mice by inhibiting an NF-kappa B-dependent CXCL1\/CXCR2 signaling pathway. Neuropharmacology 135:34\u201347","journal-title":"Neuropharmacology"},{"key":"4110_CR40","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1007\/s13311-019-00784-7","volume":"17","author":"L Zhou","year":"2020","unstructured":"Zhou L, Ao L, Yan Y, Li C, Li W, Ye A, Liu J, Hu Y, Fang W, Li Y (2020) Levo-corydalmine attenuates vincristine-induced neuropathic pain in mice by upregulating the Nrf2\/HO-1\/CO pathway to inhibit connexin 43 expression. Neurotherapeutics 17:340\u2013355","journal-title":"Neurotherapeutics"},{"key":"4110_CR41","doi-asserted-by":"publisher","first-page":"117084","DOI":"10.1016\/j.jep.2023.117084","volume":"319","author":"MY Zhou","year":"2024","unstructured":"Zhou MY, Yao CH, Yang YJ, Li X, Yang J, Liu JH, Yu BY, Dai WL (2024) Based on spinal central sensitization creating analgesic screening approach to excavate anti-neuropathic pain ingredients of Corydalis yanhusuo W.T.Wang. J Ethnopharmacol 319:117084","journal-title":"J Ethnopharmacol"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04110-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-025-04110-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04110-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T04:37:48Z","timestamp":1758256668000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-025-04110-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,7]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["4110"],"URL":"https:\/\/doi.org\/10.1007\/s00210-025-04110-1","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"type":"print","value":"0028-1298"},{"type":"electronic","value":"1432-1912"}],"subject":[],"published":{"date-parts":[[2025,4,7]]},"assertion":[{"value":"16 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The current study was approved by the Institutional Animal Care and Use Committee of Sun Yat-sen University (approval number: SYSU-IACUC-2024\u2013001557), IEC for Clinical Research and Animal Trials of the First Affiliated Hospital of Sun Yat-sen University (approval number: [2020]051) and Ethics Review Committee of Guangdong Provincial People\u2019s Hospital (approval number: KY2023-752\u201301).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}