{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:01:38Z","timestamp":1790654498484,"version":"4.1.0"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s00210-025-04152-5","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T05:55:22Z","timestamp":1744696522000},"page":"13881-13894","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Psilocin alleviates acute itch in mice: possible involvement of 5-HT2A receptors and kynurenine pathway"],"prefix":"10.1007","volume":"398","author":[{"given":"Arya","family":"Afrooghe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Ahmadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Lesani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahya Soleymani","family":"Mehranjani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Elahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza","family":"Babaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Shayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamed","family":"Shafaroodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razieh Mohammad","family":"Jafari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Foroumadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Amin","family":"Manavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad-Reza","family":"Dehpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"4152_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.109919","volume":"117","author":"A Afrooghe","year":"2023","unstructured":"Afrooghe A, Babaei M, Shayan M, Ahmadi E, Mohammad Jafari R, Dehpour AR (2023) Therapeutic potential of bromhexine for acute itch in mice: involvement of TMPRSS2 and kynurenine pathway. Int Immunopharmacol 117:109919","journal-title":"Int Immunopharmacol"},{"key":"4152_CR2","doi-asserted-by":"publisher","unstructured":"Billac GB, Flanagan TW, Nichols CD (2020) Elucidating anti\u2010inflammatory SAR at the 5\u2010HT2A receptor. FASEB J 34(S1):1. https:\/\/doi.org\/10.1096\/fasebj.2020.34.s1.06584","DOI":"10.1096\/fasebj.2020.34.s1.06584"},{"issue":"1","key":"4152_CR3","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1097\/PSY.0b013e31815c1b71","volume":"70","author":"Y Chida","year":"2008","unstructured":"Chida Y, Hamer M, Steptoe A (2008) A bidirectional relationship between psychosocial factors and atopic disorders: a systematic review and meta-analysis. Psychosom Med 70(1):102\u2013116","journal-title":"Psychosom Med"},{"issue":"1","key":"4152_CR4","doi-asserted-by":"publisher","first-page":"24","DOI":"10.9740\/mhc.2017.01.024","volume":"7","author":"J Daniel","year":"2017","unstructured":"Daniel J, Haberman M (2017) Clinical potential of psilocybin as a treatment for mental health conditions. Ment Health Clin 7(1):24\u201328","journal-title":"Ment Health Clin"},{"key":"4152_CR5","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/7854_2016_6","volume":"31","author":"R Dantzer","year":"2017","unstructured":"Dantzer R (2017) Role of the kynurenine metabolism pathway in inflammation-induced depression: preclinical approaches. Curr Top Behav Neurosci 31:117\u2013138","journal-title":"Curr Top Behav Neurosci"},{"issue":"1","key":"4152_CR6","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1080\/03602532.2016.1278228","volume":"49","author":"RJ Dinis-Oliveira","year":"2017","unstructured":"Dinis-Oliveira RJ (2017) Metabolism of psilocybin and psilocin: clinical and forensic toxicological relevance. Drug Metab Rev 49(1):84\u201391","journal-title":"Drug Metab Rev"},{"key":"4152_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.559589","volume":"11","author":"A Dondalska","year":"2020","unstructured":"Dondalska A, R\u00f6nnberg E, Ma H, P\u00e5lsson SA, Magnusdottir E, Gao T et al (2020) Amelioration of Compound 48\/80-mediated itch and LL-37-induced inflammation by a single-stranded oligonucleotide. Front Immunol 11:559589","journal-title":"Front Immunol"},{"key":"4152_CR8","doi-asserted-by":"publisher","unstructured":"Erkizia-Santamar\u00eda I, Alles-Pascual R, Horrillo I, Meana JJ, Ortega JE (2022) Serotonin 5-HT2A, 5-HT2c and 5-HT1A receptor involvement in the acute effects of psilocybin in mice. In vitro pharmacological profile and modulation of thermoregulation and head-twich response. Biomed Pharmacother 154:113612. https:\/\/doi.org\/10.1016\/j.biopha.2022.113612","DOI":"10.1016\/j.biopha.2022.113612"},{"issue":"5","key":"4152_CR9","doi-asserted-by":"publisher","first-page":"G877","DOI":"10.1152\/ajpgi.00435.2001","volume":"282","author":"E Fiorica-Howells","year":"2002","unstructured":"Fiorica-Howells E, Hen R, Gingrich J, Li Z, Gershon MD (2002) 5-HT(2A) receptors: location and functional analysis in intestines of wild-type and 5-HT(2A) knockout mice. Am J Physiol Gastrointest Liver Physiol 282(5):G877\u2013G893","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"4","key":"4152_CR10","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1080\/09540261.2018.1481827","volume":"30","author":"TW Flanagan","year":"2018","unstructured":"Flanagan TW, Nichols CD (2018) Psychedelics as anti-inflammatory agents. Int Rev Psychiatry 30(4):363\u2013375","journal-title":"Int Rev Psychiatry"},{"issue":"9","key":"4152_CR11","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1111\/nmo.12619","volume":"27","author":"R Forc\u00e9n","year":"2015","unstructured":"Forc\u00e9n R, Latorre E, Pardo J, Alcalde AI, Murillo MD, Grasa L (2015) Toll-like receptors 2 and 4 modulate the contractile response induced by serotonin in mouse ileum: analysis of the serotonin receptors involved. Neurogastroenterol Motil 27(9):1258\u20131266","journal-title":"Neurogastroenterol Motil"},{"key":"4152_CR12","doi-asserted-by":"crossref","unstructured":"Fukasawa T, Yoshizaki-Ogawa A, Enomoto A, Miyagawa K, Sato S, Yoshizaki A (2022) Pharmacotherapy of itch-antihistamines and histamine receptors as G protein-coupled receptors. Int J Mol Sci 23(12):6579. https:\/\/doi.org\/10.3390\/ijms23126579","DOI":"10.3390\/ijms23126579"},{"issue":"3","key":"4152_CR13","doi-asserted-by":"publisher","first-page":"263","DOI":"10.3109\/00952999309001618","volume":"19","author":"RS Gable","year":"1993","unstructured":"Gable RS (1993) Toward a comparative overview of dependence potential and acute toxicity of psychoactive substances used nonmedically. Am J Drug Alcohol Abuse 19(3):263\u2013281","journal-title":"Am J Drug Alcohol Abuse"},{"key":"4152_CR14","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.preghy.2023.11.008","volume":"35","author":"S Gumusoglu","year":"2024","unstructured":"Gumusoglu S, Meincke CR, Kiel M, Betz A, Nuckols V, DuBose L et al (2024) Low indoleamine 2, 3 dioxygenase (IDO) activity is associated with psycho-obstetric risk. Pregnancy Hypertension 35:12\u201318","journal-title":"Pregnancy Hypertension"},{"issue":"11","key":"4152_CR15","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1177\/0269881110388326","volume":"25","author":"AL Halberstadt","year":"2011","unstructured":"Halberstadt AL, Koedood L, Powell SB, Geyer MA (2011) Differential contributions of serotonin receptors to the behavioral effects of indoleamine hallucinogens in mice. J Psychopharmacol 25(11):1548\u20131561","journal-title":"J Psychopharmacol"},{"issue":"5","key":"4152_CR16","doi-asserted-by":"publisher","first-page":"543","DOI":"10.2340\/00015555-1251","volume":"92","author":"JA Halvorsen","year":"2012","unstructured":"Halvorsen JA, Dalgard F, Thoresen M, Bjertness E, Lien L (2012) Itch and pain in adolescents are associated with suicidal ideation: a population-based cross-sectional study. Acta Derm Venereol 92(5):543\u2013546","journal-title":"Acta Derm Venereol"},{"issue":"6","key":"4152_CR17","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1016\/j.jaci.2015.09.055","volume":"137","author":"JL Harden","year":"2016","unstructured":"Harden JL, Lewis SM, Lish SR, Su\u00e1rez-Fari\u00f1as M, Gareau D, Lentini T et al (2016) The tryptophan metabolism enzyme L-kynureninase is a novel inflammatory factor in psoriasis and other inflammatory diseases. J Allergy Clinical Immunology 137(6):1830\u20131840","journal-title":"J Allergy Clinical Immunology"},{"key":"4152_CR18","doi-asserted-by":"publisher","first-page":"158","DOI":"10.3389\/fendo.2019.00158","volume":"10","author":"E Hoglund","year":"2019","unstructured":"Hoglund E, Overli O, Winberg S (2019) Tryptophan metabolic pathways and brain serotonergic activity: a comparative review. Front Endocrinol (Lausanne) 10:158","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"4152_CR19","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/ijd.14081","volume":"58","author":"M Jafferany","year":"2019","unstructured":"Jafferany M, Davari ME (2019) Itch and psyche: psychiatric aspects of pruritus. Int J Dermatol 58(1):3\u201323","journal-title":"Int J Dermatol"},{"key":"4152_CR20","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.neuropharm.2018.05.012","volume":"142","author":"MW Johnson","year":"2018","unstructured":"Johnson MW, Griffiths RR, Hendricks PS, Henningfield JE (2018) The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act. Neuropharmacology 142:143\u2013166","journal-title":"Neuropharmacology"},{"issue":"14","key":"4152_CR21","doi-asserted-by":"publisher","first-page":"4883","DOI":"10.3390\/ijms21144883","volume":"21","author":"S Kahremany","year":"2020","unstructured":"Kahremany S, Hofmann L, Gruzman A, Cohen G (2020) Advances in understanding the initial steps of pruritoceptive itch: how the itch hits the switch. Int J Mol Sci 21(14):4883","journal-title":"Int J Mol Sci"},{"issue":"1","key":"4152_CR22","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/jnc.15509","volume":"162","author":"U Kozlowska","year":"2022","unstructured":"Kozlowska U, Nichols C, Wiatr K, Figiel M (2022) From psychiatry to neurology: psychedelics as prospective therapeutics for neurodegenerative disorders. J Neurochem 162(1):89\u2013108","journal-title":"J Neurochem"},{"issue":"6","key":"4152_CR23","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1007\/s00702-013-1011-3","volume":"120","author":"O Lairez","year":"2013","unstructured":"Lairez O, Cognet T, Schaak S, Calise D, Guilbeau-Frugier C, Parini A et al (2013) Role of serotonin 5-HT2A receptors in the development of cardiac hypertrophy in response to aortic constriction in mice. J Neural Transm (Vienna) 120(6):927\u2013935","journal-title":"J Neural Transm (Vienna)"},{"key":"4152_CR24","doi-asserted-by":"publisher","unstructured":"Liu Y, Peng Y. 2 (2013) TNF-alpha mediates depressive-like behavior induced by chronic mild stress through upregulation of indoleamine 2,3-dioxygenase in mice. Brain, Behavior, and Immunity 32:e1. https:\/\/doi.org\/10.1016\/j.bbi.2013.07.014","DOI":"10.1016\/j.bbi.2013.07.014"},{"key":"4152_CR25","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/7854_2017_478","volume":"36","author":"JF L\u00f3pez-Gim\u00e9nez","year":"2018","unstructured":"L\u00f3pez-Gim\u00e9nez JF, Gonz\u00e1lez-Maeso J (2018) Hallucinogens and serotonin 5-HT(2A) receptor-mediated signaling pathways. Curr Top Behav Neurosci 36:45\u201373","journal-title":"Curr Top Behav Neurosci"},{"key":"4152_CR26","doi-asserted-by":"publisher","first-page":"1040217","DOI":"10.3389\/fpsyt.2022.1040217","volume":"13","author":"CA MacCallum","year":"2022","unstructured":"MacCallum CA, Lo LA, Pistawka CA, Deol JK (2022) Therapeutic use of psilocybin: practical considerations for dosing and administration. Front Psychiatry 13:1040217","journal-title":"Front Psychiatry"},{"key":"4152_CR27","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.euroneuro.2020.02.001","volume":"33","author":"MK Madsen","year":"2020","unstructured":"Madsen MK, Fisher PM, Stenb\u00e6k DS, Kristiansen S, Burmester D, Lehel S et al (2020) A single psilocybin dose is associated with long-term increased mindfulness, preceded by a proportional change in neocortical 5-HT2A receptor binding. Eur Neuropsychopharmacol 33:71\u201380","journal-title":"Eur Neuropsychopharmacol"},{"issue":"3","key":"4152_CR28","doi-asserted-by":"publisher","first-page":"331","DOI":"10.2340\/00015555-2263","volume":"96","author":"SE Marron","year":"2016","unstructured":"Marron SE, Tomas-Aragones L, Boira S, Campos-Rodenas R (2016) Quality of Life, Emotional wellbeing and family repercussions in dermatological patients experiencing chronic itching: a pilot study. Acta Derm Venereol 96(3):331\u2013335","journal-title":"Acta Derm Venereol"},{"issue":"8","key":"4152_CR29","doi-asserted-by":"publisher","first-page":"4158","DOI":"10.1038\/s41380-020-00951-9","volume":"26","author":"W Marx","year":"2021","unstructured":"Marx W, McGuinness AJ, Rocks T, Ruusunen A, Cleminson J, Walker AJ et al (2021) The kynurenine pathway in major depressive disorder, bipolar disorder, and schizophrenia: a meta-analysis of 101 studies. Mol Psychiatry 26(8):4158\u20134178","journal-title":"Mol Psychiatry"},{"key":"4152_CR30","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.bbi.2023.09.004","volume":"114","author":"NL Mason","year":"2023","unstructured":"Mason NL, Szabo A, Kuypers KPC, Mallaroni PA, de la Torre FR, Reckweg JT et al (2023) Psilocybin induces acute and persisting alterations in immune status in healthy volunteers: An experimental, placebo-controlled study. Brain Behav Immun 114:299\u2013310","journal-title":"Brain Behav Immun"},{"issue":"12","key":"4152_CR31","doi-asserted-by":"publisher","first-page":"1954","DOI":"10.1248\/bpb.b15-00637","volume":"38","author":"N Matsui","year":"2015","unstructured":"Matsui N, Ito D, Takabatake Y, Nashioka E, Tada S, Kanagawa M et al (2015) Compound 48\/80, a mast cell stimulator, enhances synthesis of IgE and IgG induced by intranasal application of ovalbumin in mice. Biol Pharm Bull 38(12):1954\u20131959","journal-title":"Biol Pharm Bull"},{"issue":"5","key":"4152_CR32","doi-asserted-by":"publisher","first-page":"532","DOI":"10.2340\/00015555-1572","volume":"93","author":"U Matterne","year":"2013","unstructured":"Matterne U, Apfelbacher CJ, Vogelgsang L, Loerbroks A, Weisshaar E (2013) Incidence and determinants of chronic pruritus: a population-based cohort study. Acta Derm Venereol 93(5):532\u2013537","journal-title":"Acta Derm Venereol"},{"issue":"1","key":"4152_CR33","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s12264-017-0124-3","volume":"34","author":"X Miao","year":"2018","unstructured":"Miao X, Huang Y, Liu TT, Guo R, Wang B, Wang XL et al (2018) TNF-\u03b1\/TNFR1 signaling is required for the full expression of acute and chronic itch in mice via peripheral and central mechanisms. Neurosci Bull 34(1):42\u201353","journal-title":"Neurosci Bull"},{"key":"4152_CR34","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s13041-014-0059-9","volume":"7","author":"H Min","year":"2014","unstructured":"Min H, Lee H, Lim H, Jang YH, Chung SJ, Lee CJ et al (2014) TLR4 enhances histamine-mediated pruritus by potentiating TRPV1 activity. Mol Brain 7:59","journal-title":"Mol Brain"},{"key":"4152_CR35","doi-asserted-by":"publisher","unstructured":"Mithaiwala MN, Santana-Coelho D, Porter GA, O'Connor JC (2021) Neuroinflammation and the kynurenine pathway in CNS disease: molecular mechanisms and therapeutic implications. Cells 10(6). https:\/\/doi.org\/10.3390\/cells10061548","DOI":"10.3390\/cells10061548"},{"issue":"10","key":"4152_CR36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075426","volume":"8","author":"F Nau Jr","year":"2013","unstructured":"Nau F Jr, Yu B, Martin D, Nichols CD (2013) Serotonin 5-HT2A receptor activation blocks TNF-\u03b1 mediated inflammation in vivo. PLoS ONE 8(10):e75426","journal-title":"PLoS ONE"},{"issue":"2","key":"4152_CR37","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1124\/pr.115.011478","volume":"68","author":"DE Nichols","year":"2016","unstructured":"Nichols DE (2016) Psychedelics. Pharmacol Rev 68(2):264\u2013355","journal-title":"Pharmacol Rev"},{"key":"4152_CR38","doi-asserted-by":"crossref","unstructured":"Orhan F, Bhat M, Sandberg K, Stahl S, Piehl F, Karolinska Schizophrenia Project c et al (2016) Tryptophan metabolism along the kynurenine pathway downstream of toll-like receptor stimulation in peripheral monocytes. Scand J Immunol 84(5):262\u201371","DOI":"10.1111\/sji.12479"},{"key":"4152_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2023.108247","volume":"69","author":"M Pepe","year":"2023","unstructured":"Pepe M, Hesami M, de la Cerda KA, Perreault ML, Hsiang T, Jones AMP (2023) A journey with psychedelic mushrooms: from historical relevance to biology, cultivation, medicinal uses, biotechnology, and beyond. Biotechnol Adv 69:108247","journal-title":"Biotechnol Adv"},{"key":"4152_CR40","doi-asserted-by":"publisher","unstructured":"Percie du Sert N, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ et al (2020) Reporting animal research: explanation and elaboration for the ARRIVE guidelines 2.0. PLoS Biol 18(7):e3000411. https:\/\/doi.org\/10.1371\/journal.pbio.3000411","DOI":"10.1371\/journal.pbio.3000411"},{"key":"4152_CR41","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.825591","volume":"13","author":"H Qian","year":"2022","unstructured":"Qian H, Shu C, Xiao L, Wang G (2022) Histamine and histamine receptors: roles in major depressive disorder. Front Psychiatry 13:825591","journal-title":"Front Psychiatry"},{"key":"4152_CR42","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.831092","volume":"13","author":"CL Raison","year":"2022","unstructured":"Raison CL, Jain R, Penn AD, Cole SP, Jain S (2022) Effects of naturalistic psychedelic use on depression, anxiety, and well-being: associations with patterns of use, reported harms, and transformative mental states. Front Psychiatry 13:831092","journal-title":"Front Psychiatry"},{"issue":"1","key":"4152_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaad.2021.07.076","volume":"86","author":"YS Roh","year":"2022","unstructured":"Roh YS, Choi J, Sutaria N, Kwatra SG (2022) Itch: epidemiology, clinical presentation, and diagnostic workup. J Am Acad Dermatol 86(1):1\u201314","journal-title":"J Am Acad Dermatol"},{"key":"4152_CR44","doi-asserted-by":"publisher","first-page":"43337","DOI":"10.1038\/srep43337","volume":"7","author":"F Salazar","year":"2017","unstructured":"Salazar F, Awuah D, Negm OH, Shakib F, Ghaemmaghami AM (2017) The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs. Sci Rep 7:43337","journal-title":"Sci Rep"},{"key":"4152_CR45","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.neubiorev.2018.01.009","volume":"87","author":"KM Sanders","year":"2018","unstructured":"Sanders KM, Akiyama T (2018) The vicious cycle of itch and anxiety. Neurosci Biobehav Rev 87:17\u201326","journal-title":"Neurosci Biobehav Rev"},{"issue":"10","key":"4152_CR46","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.1111\/bph.15733","volume":"179","author":"B Sanjel","year":"2022","unstructured":"Sanjel B, Kim BH, Song MH, Carstens E, Shim WS (2022) Glucosylsphingosine evokes pruritus via activation of 5-HT(2A) receptor and TRPV4 in sensory neurons. Br J Pharmacol 179(10):2193\u20132207","journal-title":"Br J Pharmacol"},{"issue":"1","key":"4152_CR47","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1124\/jpet.108.150136","volume":"329","author":"JE Schlosburg","year":"2009","unstructured":"Schlosburg JE, Boger DL, Cravatt BF, Lichtman AH (2009) Endocannabinoid modulation of scratching response in an acute allergenic model: a new prospective neural therapeutic target for pruritus. J Pharmacol Exp Ther 329(1):314\u2013323","journal-title":"J Pharmacol Exp Ther"},{"issue":"22","key":"4152_CR48","doi-asserted-by":"publisher","first-page":"14148","DOI":"10.3390\/ijms232214148","volume":"23","author":"O Shahar","year":"2022","unstructured":"Shahar O, Botvinnik A, Esh-Zuntz N, Brownstien M, Wolf R, Lotan A et al (2022) Role of 5-HT2A, 5-HT2C, 5-HT1A and TAAR1 receptors in the head twitch response induced by 5-hydroxytryptophan and psilocybin: translational implications. Int J Mol Sci 23(22):14148","journal-title":"Int J Mol Sci"},{"key":"4152_CR49","doi-asserted-by":"publisher","first-page":"15","DOI":"10.4137\/IJTR.S9835","volume":"5","author":"D Sheipouri","year":"2012","unstructured":"Sheipouri D, Braidy N, Guillemin GJ (2012) Kynurenine pathway in skin cells: implications for UV-induced skin damage. Int J Tryptophan Res 5:15\u201325","journal-title":"Int J Tryptophan Res"},{"key":"4152_CR50","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/1744-8069-4-29","volume":"4","author":"WS Shim","year":"2008","unstructured":"Shim WS, Oh U (2008) Histamine-induced itch and its relationship with pain. Mol Pain 4:29","journal-title":"Mol Pain"},{"issue":"3","key":"4152_CR51","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.pain.2008.08.002","volume":"139","author":"SG Shimada","year":"2008","unstructured":"Shimada SG, LaMotte RH (2008) Behavioral differentiation between itch and pain in mouse. Pain 139(3):681\u2013687","journal-title":"Pain"},{"key":"4152_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108160","volume":"100","author":"M Shokrian Zeini","year":"2021","unstructured":"Shokrian Zeini M, Haddadi N-S, Shayan M, Shokrian Zeini M, Kazemi K, Solaimanian S et al (2021) Losartan ointment attenuates imiquimod-induced psoriasis-like inflammation. Int Immunopharmacol 100:108160","journal-title":"Int Immunopharmacol"},{"issue":"6","key":"4152_CR53","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s40257-016-0215-3","volume":"17","author":"JI Silverberg","year":"2016","unstructured":"Silverberg JI, Hinami K, Trick WE, Cella D (2016) Itch in the general internal medicine setting: a cross-sectional study of prevalence and quality-of-life effects. Am J Clin Dermatol 17(6):681\u2013690","journal-title":"Am J Clin Dermatol"},{"key":"4152_CR54","doi-asserted-by":"publisher","first-page":"9625936","DOI":"10.1155\/2018\/9625936","volume":"2018","author":"J Song","year":"2018","unstructured":"Song J, Xian D, Yang L, Xiong X, Lai R, Zhong J (2018) Pruritus: progress toward pathogenesis and treatment. Biomed Res Int 2018:9625936","journal-title":"Biomed Res Int"},{"issue":"11","key":"4152_CR55","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1001\/archderm.139.11.1463","volume":"139","author":"S St\u00e4nder","year":"2003","unstructured":"St\u00e4nder S, Steinhoff M, Schmelz M, Weisshaar E, Metze D, Luger T (2003) Neurophysiology of pruritus: cutaneous elicitation of itch. Arch Dermatol 139(11):1463\u20131470","journal-title":"Arch Dermatol"},{"key":"4152_CR56","doi-asserted-by":"crossref","unstructured":"Strumila R, Nobile B, Korsakova L, Lengvenyte A, Olie E, Lopez-Castroman J,\u00a0Guillaume S, Courtet P (2021) Psilocybin, a naturally occurring indoleamine compound, could be useful to prevent suicidal behaviors. Pharmaceuticals (Basel) 14(12):1213. https:\/\/doi.org\/10.3390\/ph14121213","DOI":"10.3390\/ph14121213"},{"issue":"11","key":"4152_CR57","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1177\/0269881110382466","volume":"25","author":"E Studerus","year":"2011","unstructured":"Studerus E, Kometer M, Hasler F, Vollenweider FX (2011) Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies. J Psychopharmacol 25(11):1434\u20131452","journal-title":"J Psychopharmacol"},{"issue":"1","key":"4152_CR58","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/s41398-022-01846-9","volume":"12","author":"CW Thomas","year":"2022","unstructured":"Thomas CW, Blanco-Duque C, Br\u00e9ant BJ, Goodwin GM, Sharp T, Bannerman DM et al (2022) Psilocin acutely alters sleep-wake architecture and cortical brain activity in laboratory mice. Transl Psychiatry 12(1):77","journal-title":"Transl Psychiatry"},{"issue":"3","key":"4152_CR59","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.alit.2022.04.003","volume":"71","author":"M Tominaga","year":"2022","unstructured":"Tominaga M, Takamori K (2022) Peripheral itch sensitization in atopic dermatitis. Allergol Int 71(3):265\u2013277","journal-title":"Allergol Int"},{"issue":"9","key":"4152_CR60","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1038\/nrn2884","volume":"11","author":"FX Vollenweider","year":"2010","unstructured":"Vollenweider FX, Kometer M (2010) The neurobiology of psychedelic drugs: implications for the treatment of mood disorders. Nat Rev Neurosci 11(9):642\u2013651","journal-title":"Nat Rev Neurosci"},{"issue":"5","key":"4152_CR61","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.immuni.2020.04.008","volume":"52","author":"F Wang","year":"2020","unstructured":"Wang F, Kim BS (2020) Itch: a paradigm of neuroimmune crosstalk. Immunity 52(5):753\u2013766","journal-title":"Immunity"},{"key":"4152_CR62","doi-asserted-by":"publisher","unstructured":"Weisshaar E (2016) Epidemiology of Itch. In: Szepietowski J, Weisshaar E (eds) Itch - management in clinical practice. 50: S.Karger AG, pp 10. https:\/\/doi.org\/10.1159\/000446010","DOI":"10.1159\/000446010"},{"key":"4152_CR63","doi-asserted-by":"publisher","unstructured":"Wiens KR, Brooks NAH, Riar I, Greuel BK, Lindhout IA, Klegeris A (2024) Psilocin, the psychoactive metabolite of psilocybin, modulates select neuroimmune functions of microglial cells in a 5-HT(2) receptor-dependent manner. Molecules 29(21). https:\/\/doi.org\/10.3390\/molecules29215084","DOI":"10.3390\/molecules29215084"},{"issue":"6","key":"4152_CR64","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s10157-023-02332-2","volume":"27","author":"W Wu","year":"2023","unstructured":"Wu W, Zhong W, Lin Z, Yan J (2023) Blockade of Indoleamine 2,3-Dioxygenase attenuates lipopolysaccharide-induced kidney injury by inhibiting TLR4\/NF-\u03baB signaling. Clin Exp Nephrol 27(6):495\u2013505","journal-title":"Clin Exp Nephrol"},{"issue":"2","key":"4152_CR65","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1124\/jpet.108.143461","volume":"327","author":"B Yu","year":"2008","unstructured":"Yu B, Becnel J, Zerfaoui M, Rohatgi R, Boulares AH, Nichols CD (2008) Serotonin 5-hydroxytryptamine(2A) receptor activation suppresses tumor necrosis factor-alpha-induced inflammation with extraordinary potency. J Pharmacol Exp Ther 327(2):316\u2013323","journal-title":"J Pharmacol Exp Ther"},{"key":"4152_CR66","doi-asserted-by":"crossref","unstructured":"Yue Y, Zhong M, An X, Feng Q, Lai Y, Yu M, et al (2022) Serotonin (5-HT) 2A receptor involvement in melanin synthesis and transfer via activating the PKA\/CREB signaling pathway. Int J Mol Sci 23(11)","DOI":"10.3390\/ijms23116111"},{"issue":"4","key":"4152_CR67","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.3390\/toxins7041018","volume":"7","author":"O Zhuk","year":"2015","unstructured":"Zhuk O, Jasicka-Misiak I, Poliwoda A, Kazakova A, Godovan VV, Halama M et al (2015) Research on acute toxicity and the behavioral effects of methanolic extract from psilocybin mushrooms and psilocin in mice. Toxins (Basel) 7(4):1018\u20131029","journal-title":"Toxins (Basel)"},{"key":"4152_CR68","doi-asserted-by":"publisher","unstructured":"Zi\u0119ba A, St\u0119pnicki P, Matosiuk D, Kaczor AA (2021) Overcoming depression with 5-HT(2A) receptor ligands. Int J Mol Sci 23(1). https:\/\/doi.org\/10.3390\/ijms23010010","DOI":"10.3390\/ijms23010010"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04152-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-025-04152-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04152-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T05:03:56Z","timestamp":1759986236000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-025-04152-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,15]]},"references-count":68,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["4152"],"URL":"https:\/\/doi.org\/10.1007\/s00210-025-04152-5","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,15]]},"assertion":[{"value":"22 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was granted approval by the Ethics in Medical Research Committee at Tehran University of Medical Sciences (Ethical approval code: IR.TUMS.MEDICINE.REC.1403.130).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}