{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:22:39Z","timestamp":1785943359235,"version":"3.56.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s00210-025-04164-1","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T22:00:20Z","timestamp":1745532020000},"page":"14219-14238","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Puerarin raises exosomal miR- 342 -\u20093p by inhibiting lncRNA NEAT1 in umbilical cord mesenchymal stem cells to alleviate renal tubular epithelial cell pyroptosis in chronic renal failure"],"prefix":"10.1007","volume":"398","author":[{"given":"Jing","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxue","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanxin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxing","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"issue":"11","key":"4164_CR1","doi-asserted-by":"publisher","first-page":"5248","DOI":"10.7150\/thno.54550","volume":"11","author":"JY Cao","year":"2021","unstructured":"Cao JY et al (2021) Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury. Theranostics 11(11):5248\u20135266","journal-title":"Theranostics"},{"issue":"1","key":"4164_CR2","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s00240-023-01527-2","volume":"52","author":"W Cao","year":"2024","unstructured":"Cao W et al (2024) N-acetylcysteine regulates oxalate induced injury of renal tubular epithelial cells through CDKN2B\/TGF-\u03b2\/SMAD axis. Urolithiasis 52(1):46","journal-title":"Urolithiasis"},{"issue":"3","key":"4164_CR3","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14454","volume":"30","author":"J Che","year":"2024","unstructured":"Che J et al (2024) Human umbilical cord mesenchymal stem cell-derived exosomes attenuate neuroinflammation and oxidative stress through the NRF2\/NF-\u03baB\/NLRP3 pathway. CNS Neurosci Ther 30(3):e14454","journal-title":"CNS Neurosci Ther"},{"issue":"3","key":"4164_CR4","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12203","volume":"11","author":"S Chen","year":"2022","unstructured":"Chen S et al (2022) \u03b2-catenin-controlled tubular cell-derived exosomes play a key role in fibroblast activation via the OPN-CD44 axis. J Extracell Vesicles 11(3):e12203","journal-title":"J Extracell Vesicles"},{"issue":"2","key":"4164_CR5","doi-asserted-by":"publisher","first-page":"C292","DOI":"10.1152\/ajpcell.00382.2021","volume":"324","author":"Y Chen","year":"2023","unstructured":"Chen Y et al (2023) LncRNA NEAT1 accelerates renal fibrosis progression via targeting miR-31 and modulating RhoA\/ROCK signal pathway. Am J Physiol Cell Physiol 324(2):C292-c306","journal-title":"Am J Physiol Cell Physiol"},{"issue":"11","key":"4164_CR6","doi-asserted-by":"publisher","first-page":"2362","DOI":"10.1016\/j.bbadis.2015.08.010","volume":"1852","author":"K Essandoh","year":"2015","unstructured":"Essandoh K et al (2015) Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction. Biochim Biophys Acta 1852(11):2362\u20132371","journal-title":"Biochim Biophys Acta"},{"key":"4164_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109429","volume":"114","author":"J Fang","year":"2023","unstructured":"Fang J et al (2023) Neoxanthin alleviates the chronic renal failure-induced aging and fibrosis by regulating inflammatory process. Int Immunopharmacol 114:109429","journal-title":"Int Immunopharmacol"},{"key":"4164_CR8","doi-asserted-by":"publisher","first-page":"8145129","DOI":"10.1155\/2022\/8145129","volume":"2022","author":"Z Gong","year":"2022","unstructured":"Gong Z et al (2022) LncRNA NEAT1 targets miR-342-3p\/CUL4B to inhibit the proliferation of cutaneous squamous cell carcinoma cells. J Oncol 2022:8145129","journal-title":"J Oncol"},{"issue":"1","key":"4164_CR9","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41401-020-0401-y","volume":"42","author":"N Hou","year":"2021","unstructured":"Hou N et al (2021) Puerarin ameliorated pressure overload-induced cardiac hypertrophy in ovariectomized rats through activation of the PPAR\u03b1\/PGC-1 pathway. Acta Pharmacol Sin 42(1):55\u201367","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"4164_CR10","doi-asserted-by":"publisher","first-page":"20230850","DOI":"10.1515\/med-2023-0850","volume":"18","author":"X Huang","year":"2023","unstructured":"Huang X et al (2023) Adipose-derived stem cells repair radiation-induced chronic lung injury via inhibiting TGF-\u03b21\/Smad 3 signaling pathway. Open Med (Wars) 18(1):20230850","journal-title":"Open Med (Wars)"},{"key":"4164_CR11","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.jot.2023.10.004","volume":"46","author":"S Jia","year":"2024","unstructured":"Jia S et al (2024) Exosomes from umbilical cord mesenchymal stem cells ameliorate intervertebral disc degeneration via repairing mitochondrial dysfunction. J Orthop Translat 46:103\u2013115","journal-title":"J Orthop Translat"},{"issue":"1","key":"4164_CR12","first-page":"95","volume":"70","author":"HY Jiang","year":"2018","unstructured":"Jiang HY et al (2018) Clinical observation of umbilical cord mesenchymal stem cell transplantation for treating patients receiving peritoneal dialysis. Minerva Urol Nefrol 70(1):95\u2013101","journal-title":"Minerva Urol Nefrol"},{"issue":"5","key":"4164_CR13","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1634\/stemcells.2005-0342","volume":"24","author":"S Kern","year":"2006","unstructured":"Kern S et al (2006) Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 24(5):1294\u20131301","journal-title":"Stem Cells"},{"issue":"1\u20132","key":"4164_CR14","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s11010-016-2930-8","volume":"428","author":"W Li","year":"2017","unstructured":"Li W et al (2017) Icariin combined with human umbilical cord mesenchymal stem cells significantly improve the impaired kidney function in chronic renal failure. Mol Cell Biochem 428(1\u20132):203\u2013212","journal-title":"Mol Cell Biochem"},{"issue":"4","key":"4164_CR15","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1007\/s00204-021-02993-6","volume":"95","author":"H Li","year":"2021","unstructured":"Li H et al (2021) Ochratoxin A induces nephrotoxicity in vitro and in vivo via pyroptosis. Arch Toxicol 95(4):1489\u20131502","journal-title":"Arch Toxicol"},{"issue":"9","key":"4164_CR16","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.3724\/abbs.2024049","volume":"56","author":"X Liao","year":"2024","unstructured":"Liao X et al (2024a) Aminophylline suppresses chronic renal failure progression by activating SIRT1\/AMPK\/mTOR-dependent autophagy. Acta Biochim Biophys Sin (Shanghai) 56(9):1311\u20131322","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"issue":"1","key":"4164_CR17","doi-asserted-by":"publisher","first-page":"2354444","DOI":"10.1080\/0886022X.2024.2354444","volume":"46","author":"L Liao","year":"2024","unstructured":"Liao L et al (2024b) Bushen Huoxue formula protects against renal fibrosis and pyroptosis in chronic kidney disease by inhibiting ROS\/NLRP3-mediated inflammasome activation. Ren Fail 46(1):2354444","journal-title":"Ren Fail"},{"issue":"6","key":"4164_CR18","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1007\/s40618-023-02253-7","volume":"47","author":"J Lin","year":"2024","unstructured":"Lin J et al (2024) DACH1 attenuated PA-induced renal tubular injury through TLR4\/MyD88\/NF-\u03baB and TGF-\u03b2\/Smad signalling pathway. J Endocrinol Invest 47(6):1531\u20131544","journal-title":"J Endocrinol Invest"},{"key":"4164_CR19","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/j.biopha.2018.04.122","volume":"103","author":"Q Liu","year":"2018","unstructured":"Liu Q et al (2018) Puerarin improves methotrexate-induced renal damage by up-regulating renal expression of Oat1 and Oat3 in vivo and in vitro. Biomed Pharmacother 103:915\u2013922","journal-title":"Biomed Pharmacother"},{"key":"4164_CR20","doi-asserted-by":"publisher","first-page":"1142088","DOI":"10.3389\/fimmu.2023.1142088","volume":"14","author":"Y Liu","year":"2023","unstructured":"Liu Y et al (2023) Human umbilical cord mesenchymal stem cell-derived exosomes promote murine skin wound healing by neutrophil and macrophage modulations revealed by single-cell RNA sequencing. Front Immunol 14:1142088","journal-title":"Front Immunol"},{"issue":"1","key":"4164_CR21","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1186\/s13018-024-04651-w","volume":"19","author":"Z Luan","year":"2024","unstructured":"Luan Z et al (2024) Exosomes derived from umbilical cord-mesenchymal stem cells inhibit the NF-\u03baB\/MAPK signaling pathway and reduce the inflammatory response to promote recovery from spinal cord injury. J Orthop Surg Res 19(1):184","journal-title":"J Orthop Surg Res"},{"issue":"10","key":"4164_CR22","doi-asserted-by":"publisher","first-page":"3313","DOI":"10.1016\/j.ymthe.2022.05.019","volume":"30","author":"T Ma","year":"2022","unstructured":"Ma T et al (2022) Neat1 promotes acute kidney injury to chronic kidney disease by facilitating tubular epithelial cells apoptosis via sequestering miR-129-5p. Mol Ther 30(10):3313\u20133332","journal-title":"Mol Ther"},{"key":"4164_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154465","volume":"107","author":"F Meng","year":"2022","unstructured":"Meng F et al (2022) Puerarin: a review of its mechanisms of action and clinical studies in ophthalmology. Phytomedicine 107:154465","journal-title":"Phytomedicine"},{"key":"4164_CR24","doi-asserted-by":"publisher","unstructured":"Mu Z et al (2024) Endoplasmic reticulum stress induces renal fibrosis in high\u2011fat diet mice via the TGF\u2011\u03b2\/SMAD pathway. Mol Med Rep 30(6). https:\/\/doi.org\/10.3892\/mmr.2024.13360","DOI":"10.3892\/mmr.2024.13360"},{"key":"4164_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122543","volume":"343","author":"S Ozkan","year":"2024","unstructured":"Ozkan S et al (2024) Comparative analysis of effects of conditioned mediums obtained from 2D or 3D cultured mesenchymal stem cells on kidney functions of diabetic rats: Early intervention could potentiate transdifferentiation of parietal epithelial cell into podocyte precursors. Life Sci 343:122543","journal-title":"Life Sci"},{"issue":"5","key":"4164_CR26","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.3390\/antiox12051052","volume":"12","author":"C Ram","year":"2023","unstructured":"Ram C et al (2023) Biochanin A ameliorates nephropathy in high-fat diet\/streptozotocin-induced diabetic rats: effects on NF-kB\/NLRP3 axis, pyroptosis, and fibrosis. Antioxidants (Basel) 12(5):1052","journal-title":"Antioxidants (Basel)"},{"issue":"1","key":"4164_CR27","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13287-020-1550-0","volume":"11","author":"M Shao","year":"2020","unstructured":"Shao M et al (2020) Exosomes derived from human umbilical cord mesenchymal stem cells ameliorate IL-6-induced acute liver injury through miR-455-3p. Stem Cell Res Ther 11(1):37","journal-title":"Stem Cell Res Ther"},{"issue":"18","key":"4164_CR28","doi-asserted-by":"publisher","first-page":"18238","DOI":"10.18632\/aging.103681","volume":"12","author":"L Sun","year":"2020","unstructured":"Sun L et al (2020) The mitochondrial-targeted peptide SBT-20 ameliorates inflammation and oxidative stress in chronic renal failure. Aging (Albany NY) 12(18):18238\u201318250","journal-title":"Aging (Albany NY)"},{"issue":"4","key":"4164_CR29","doi-asserted-by":"publisher","first-page":"5319","DOI":"10.1002\/jcp.27340","volume":"234","author":"L Wang","year":"2019","unstructured":"Wang L et al (2019) Blockade of NEAT1 represses inflammation response and lipid uptake via modulating miR-342-3p in human macrophages THP-1 cells. J Cell Physiol 234(4):5319\u20135326","journal-title":"J Cell Physiol"},{"issue":"120","key":"4164_CR30","doi-asserted-by":"publisher","first-page":"8","DOI":"10.4103\/nah.nah_94_23","volume":"26","author":"L Wang","year":"2024","unstructured":"Wang L, Liu P, He X (2024) Personalized music therapy for elderly patients with chronic renal failure to improve their quality of life and mental health: a retrospective study. Noise Health 26(120):8\u201313","journal-title":"Noise Health"},{"issue":"4","key":"4164_CR31","first-page":"164","volume":"29","author":"Y Weng","year":"2023","unstructured":"Weng Y et al (2023) Effects of high-flux hemodialysis with narrative care on clinical efficacy and prognostic quality of life of patients with chronic renal failure. Altern Ther Health Med 29(4):164\u2013169","journal-title":"Altern Ther Health Med"},{"issue":"4","key":"4164_CR32","doi-asserted-by":"publisher","first-page":"3122","DOI":"10.3892\/etm.2017.4878","volume":"20","author":"Z Wu","year":"2020","unstructured":"Wu Z et al (2020) Puerarin alleviates cisplatin-induced acute renal damage and upregulates microRNA-31-related signaling. Exp Ther Med 20(4):3122\u20133129","journal-title":"Exp Ther Med"},{"key":"4164_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116733","volume":"233","author":"Y Yaghoubi","year":"2019","unstructured":"Yaghoubi Y et al (2019) Human umbilical cord mesenchymal stem cells derived-exosomes in diseases treatment. Life Sci 233:116733","journal-title":"Life Sci"},{"issue":"12","key":"4164_CR34","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1007\/s13258-023-01448-9","volume":"45","author":"J Yang","year":"2023","unstructured":"Yang J et al (2023) Puerarin alleviates chronic renal failure-induced pyroptosis in renal tubular epithelial cells by targeting miR-342-3p\/TGF-\u03b2\/SMAD axis. Genes Genomics 45(12):1563\u20131573","journal-title":"Genes Genomics"},{"issue":"1","key":"4164_CR35","first-page":"18","volume":"1","author":"J Yang","year":"2024","unstructured":"Yang J et al (2024) Inhibition of pyroptosis of renal tubular epithelial cells by puerarin via regulation of lncRNA NEAT1 ameliorating chronic renal failure. Iran J Kidney Dis 1(1):18\u201326","journal-title":"Iran J Kidney Dis"},{"issue":"1","key":"4164_CR36","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1186\/s13287-019-1332-8","volume":"10","author":"Y Yao","year":"2019","unstructured":"Yao Y et al (2019) Exosomes derived from mesenchymal stem cells reverse EMT via TGF-\u03b21\/Smad pathway and promote repair of damaged endometrium. Stem Cell Res Ther 10(1):225","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"4164_CR37","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/s41392-021-00507-5","volume":"6","author":"P Yu","year":"2021","unstructured":"Yu P et al (2021) Pyroptosis: mechanisms and diseases. Signal Transduct Target Ther 6(1):128","journal-title":"Signal Transduct Target Ther"},{"issue":"4","key":"4164_CR38","doi-asserted-by":"publisher","first-page":"699","DOI":"10.3109\/0886022X.2015.1011500","volume":"37","author":"Y Zhang","year":"2015","unstructured":"Zhang Y et al (2015) The Puerarin improves renal function in STZ-induced diabetic rats by attenuating eNOS expression. Ren Fail 37(4):699\u2013703","journal-title":"Ren Fail"},{"key":"4164_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111785","volume":"131","author":"ZW Zhang","year":"2024","unstructured":"Zhang ZW et al (2024a) Dapagliflozin prevents kidney podocytes pyroptosis via miR-155-5p\/HO-1\/NLRP3 axis modulation. Int Immunopharmacol 131:111785","journal-title":"Int Immunopharmacol"},{"key":"4164_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117101","volume":"177","author":"N Zhang","year":"2024","unstructured":"Zhang N et al (2024b) Pharmacological mechanisms of puerarin in the treatment of Parkinson\u2019s disease: an overview. Biomed Pharmacother 177:117101","journal-title":"Biomed Pharmacother"},{"key":"4164_CR41","doi-asserted-by":"publisher","first-page":"5584894","DOI":"10.1155\/2023\/5584894","volume":"2023","author":"S Zheng","year":"2023","unstructured":"Zheng S et al (2023) Human umbilical cord mesenchymal stem cells inhibit pyroptosis of renal tubular epithelial cells through miR-342-3p\/Caspase1 signaling pathway in diabetic nephropathy. Stem Cells Int 2023:5584894","journal-title":"Stem Cells Int"},{"issue":"1","key":"4164_CR42","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1080\/0886022X.2017.1305409","volume":"39","author":"X Zhou","year":"2017","unstructured":"Zhou X et al (2017) Puerarin attenuates renal fibrosis by reducing oxidative stress induced-epithelial cell apoptosis via MAPK signal pathways in vivo and in vitro. Ren Fail 39(1):423\u2013431","journal-title":"Ren Fail"},{"issue":"1","key":"4164_CR43","doi-asserted-by":"publisher","first-page":"8","DOI":"10.5114\/ceji.2022.115628","volume":"47","author":"Y Zhou","year":"2022","unstructured":"Zhou Y et al (2022) Downregulation of lncRNA NEAT1 alleviates sepsis-induced acute kidney injury. Cent Eur J Immunol 47(1):8\u201319","journal-title":"Cent Eur J Immunol"},{"key":"4164_CR44","doi-asserted-by":"publisher","first-page":"365","DOI":"10.2147\/DMSO.S225791","volume":"13","author":"B Zhu","year":"2020","unstructured":"Zhu B et al (2020) Silencing of KCNQ1OT1 decreases oxidative stress and pyroptosis of renal tubular epithelial cells. Diabetes Metab Syndr Obes 13:365\u2013375","journal-title":"Diabetes Metab Syndr Obes"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04164-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-025-04164-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04164-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T06:02:27Z","timestamp":1770012147000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-025-04164-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,25]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["4164"],"URL":"https:\/\/doi.org\/10.1007\/s00210-025-04164-1","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,25]]},"assertion":[{"value":"21 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised: There was an error in the author's institution information after the article was published.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Animal study had been ratified by the Animal Ethics Committee of the First Affiliated Department of Kunming Medical University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"N\/A.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"N\/A.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}