{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:26:35Z","timestamp":1792715195103,"version":"4.5.0"},"reference-count":128,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002352","name":"Ain Shams University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002352","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study was conducted to evaluate the impact of sodium hydrogen sulfide (NaHS) on the therapeutic efficacy of bone marrow mesenchymal stem cells (BM-MSCs) in the treatment of collagen-induced arthritis (CIA) rats.\u00a0MSCs were isolated and cultured from rat bone marrow, and their characteristics were determined. The CIA  model was induced in rats by intradermal injections of type II collagen on days 0 and 21. A variety of treatments were  administered, including naproxen, BM-MSCs, BM-MSC-conditioned media, NaHS, BM-MSCs preconditioned with  NaHS, and BM-MSCs preconditioned with NaHS-conditioned media.\u00a0The infused BM-MSCs homed to the bone trabeculae and cartilage of the knee joint, leading to significant  improvements in gait scores and a reduction in paw withdrawal frequency (PWF). Treatment with BM-MSCs and  NaHS also significantly suppressed serum levels of CRP, RF, and 14-3-3\u03b7, while downregulating TNF-\u03b1 gene  expression and MMP-1 protein levels in the synovial membrane. Histopathological analysis confirmed these  biochemical and molecular genetic findings.\u00a0Notably, CIA rats treated with BM-MSCs preconditioned with NaHS showed the most significant  improvements, with outcomes closely resembling those of healthy controls. This study concludes that NaHS enhances  the therapeutic efficacy of BM-MSC therapy for rheumatoid arthritis (RA) by augmenting their anti-inflammatory,  immunomodulatory, and regenerative properties.<\/jats:p>","DOI":"10.1007\/s00210-025-04222-8","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T06:04:55Z","timestamp":1747202695000},"page":"15645-15663","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Preconditioning of bone marrow mesenchymal stem cells with sodium hydrosulfide enhances their therapeutic potential in type II collagen\u2013induced arthritis rat model"],"prefix":"10.1007","volume":"398","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4305-5893","authenticated-orcid":false,"given":"Sara M.","family":"El-Sayed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8642-9251","authenticated-orcid":false,"given":"Hanaa H.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0837-0172","authenticated-orcid":false,"given":"Hadeer A.","family":"Aglan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2204-6627","authenticated-orcid":false,"given":"Mohamed M.","family":"Naguib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9269-3128","authenticated-orcid":false,"given":"Mohamed R.","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,14]]},"reference":[{"key":"4222_CR1","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1007\/s00210-024-03290-6","volume":"398","author":"AM Abdallah","year":"2025","unstructured":"Abdallah AM, Naiem AHA, Abdelraheim SR et al (2025) Pyrazole derivatives ameliorate synovial inflammation in collagen-induced arthritis mice model via targeting p38 MAPK and COX-2. Naunyn Schmiedebergs Arch Pharmacol 398:819\u2013832. https:\/\/doi.org\/10.1007\/s00210-024-03290-6","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"4222_CR2","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1080\/10520295.2020.1814966","volume":"96","author":"AS Abdel Halim","year":"2021","unstructured":"Abdel Halim AS, Ahmed HH, Aglan HA et al (2021) Role of bone marrow-derived mesenchymal stem cells in alleviating pulmonary epithelium damage and extracellular matrix remodeling in a rat model of lung fibrosis induced by amiodarone. Biotech Histochem off Publ Biol Stain Comm 96:418\u2013430. https:\/\/doi.org\/10.1080\/10520295.2020.1814966","journal-title":"Biotech Histochem off Publ Biol Stain Comm"},{"key":"4222_CR3","doi-asserted-by":"publisher","unstructured":"Aglan HA, Ahmed HH, Beherei HH et al (2024a) Generation of cardiomyocytes from stem cells cultured on nanofibrous scaffold: experimental approach for attenuation of myocardial infarction. Tissue Cell 89:102461. https:\/\/doi.org\/10.1016\/j.tice.2024.102461","DOI":"10.1016\/j.tice.2024.102461"},{"key":"4222_CR4","doi-asserted-by":"publisher","unstructured":"Aglan HA, Kotob SE, Mahmoud NS et al (2024b) Bone marrow stem cell-derived \u03b2-cells: new issue for diabetes cell therapy. Tissue Cell 86:102280. https:\/\/doi.org\/10.1016\/j.tice.2023.102280","DOI":"10.1016\/j.tice.2023.102280"},{"key":"4222_CR5","doi-asserted-by":"publisher","unstructured":"Ahmed EA, Ahmed OM, Fahim HI et al (2021) Combinatory effects of bone marrow-derived mesenchymal stem cells and indomethacin on adjuvant-induced arthritis in wistar rats: roles of IL-1 \u03b2, IL-4, Nrf-2, and oxidative stress. Evidence-based Complement Altern Med 2021. https:\/\/doi.org\/10.1155\/2021\/8899143","DOI":"10.1155\/2021\/8899143"},{"key":"4222_CR6","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1001\/jama.2018.13103","volume":"320","author":"D Aletaha","year":"2018","unstructured":"Aletaha D, Smolen JS (2018) Diagnosis and management of rheumatoid arthritis: a review. JAMA - J Am Med Assoc 320:1360\u20131372. https:\/\/doi.org\/10.1001\/jama.2018.13103","journal-title":"JAMA - J Am Med Assoc"},{"key":"4222_CR7","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1089\/scd.2004.13.436","volume":"13","author":"A Alhadlaq","year":"2004","unstructured":"Alhadlaq A, Mao JJ (2004) Mesenchymal stem cells: isolation and therapeutics. Stem Cells Dev 13:436\u2013448. https:\/\/doi.org\/10.1089\/scd.2004.13.436","journal-title":"Stem Cells Dev"},{"key":"4222_CR8","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1016\/j.immuni.2022.11.009","volume":"55","author":"S Alivernini","year":"2022","unstructured":"Alivernini S, Firestein GS, McInnes IB (2022) The pathogenesis of rheumatoid arthritis. Immunity 55:2255\u20132270. https:\/\/doi.org\/10.1016\/j.immuni.2022.11.009","journal-title":"Immunity"},{"key":"4222_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/biom10071002","volume":"10","author":"J Angelini","year":"2020","unstructured":"Angelini J, Talotta R, Roncato R et al (2020) JAK-inhibitors for the treatment of rheumatoid arthritis: a focus on the present and an outlook on the future. Biomolecules 10:1\u201340. https:\/\/doi.org\/10.3390\/biom10071002","journal-title":"Biomolecules"},{"key":"4222_CR10","doi-asserted-by":"publisher","first-page":"905","DOI":"10.3390\/ijms18050905","volume":"18","author":"Y Araki","year":"2017","unstructured":"Araki Y, Mimura T (2017) Matrix metalloproteinase gene activation resulting from disordred epigenetic mechanisms in rheumatoid arthritis. Int J Mol Sci 18:905. https:\/\/doi.org\/10.3390\/ijms18050905","journal-title":"Int J Mol Sci"},{"key":"4222_CR11","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1139\/cjpp-2018-0574","volume":"97","author":"K Aytekin","year":"2018","unstructured":"Aytekin K, Erhan S\u015e, Eri\u015fgin Z et al (2018) Intra-articular injection of hydrogen sulfide decreased the progression of gonarthrosis. Can J Physiol Pharmacol 97:47\u201354. https:\/\/doi.org\/10.1139\/cjpp-2018-0574","journal-title":"Can J Physiol Pharmacol"},{"key":"4222_CR12","doi-asserted-by":"publisher","first-page":"4858","DOI":"10.1074\/jbc.275.7.4858","volume":"275","author":"Y Azuma","year":"2000","unstructured":"Azuma Y, Kaji K, Katogi R et al (2000) Tumor necrosis factor-\u03b1 induces differentiation of and bone resorption by osteoclasts. J Biol Chem 275:4858\u20134864. https:\/\/doi.org\/10.1074\/jbc.275.7.4858","journal-title":"J Biol Chem"},{"key":"4222_CR13","doi-asserted-by":"publisher","first-page":"854","DOI":"10.22074\/cellj.2023.2004504.1326","volume":"25","author":"M Babaahmadi","year":"2023","unstructured":"Babaahmadi M, Makvand Gholipour N, Tayebi B et al (2023) Clinical evaluation of collagen-induced arthritis in female lewis rats: a comprehensive analysis of disease progression and severity. Cell J 25:854\u2013862. https:\/\/doi.org\/10.22074\/cellj.2023.2004504.1326","journal-title":"Cell J"},{"key":"4222_CR14","doi-asserted-by":"publisher","unstructured":"Balakumaran A, Pawelczyk E, Ren J et al (2010) Superparamagnetic iron oxide nanoparticles labeling of bone marrow stromal (Mesenchymal) cells does not affect their \u201csternness\u201d. PLoS One 5. https:\/\/doi.org\/10.1371\/journal.pone.0011462","DOI":"10.1371\/journal.pone.0011462"},{"key":"4222_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-33149-9","volume":"8","author":"J Behera","year":"2018","unstructured":"Behera J, Kelly KE, Voor MJ et al (2018) Hydrogen Sulfide promotes bone homeostasis by balancing inflammatory cytokine signaling in CBS-deficient mice through an epigenetic mechanism. Sci Rep 8:1\u201316. https:\/\/doi.org\/10.1038\/s41598-018-33149-9","journal-title":"Sci Rep"},{"key":"4222_CR16","doi-asserted-by":"publisher","first-page":"e594","DOI":"10.1016\/S2665-9913(23)00211-4","volume":"5","author":"RJ Black","year":"2023","unstructured":"Black RJ, Cross M, Haile LM et al (2023) Global, regional, and national burden of rheumatoid arthritis, 1990\u20132020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021. Lancet Rheumatol 5:e594\u2013e610. https:\/\/doi.org\/10.1016\/S2665-9913(23)00211-4","journal-title":"Lancet Rheumatol"},{"key":"4222_CR17","doi-asserted-by":"publisher","first-page":"3537","DOI":"10.1172\/JCI36389","volume":"118","author":"FM Brennan","year":"2008","unstructured":"Brennan FM, McInnes IB (2008) Evidence that cytokines play a role in rheumatoid arthritis. J Clin Invest 118:3537\u20133545. https:\/\/doi.org\/10.1172\/JCI36389","journal-title":"J Clin Invest"},{"key":"4222_CR18","unstructured":"Brutzkus JC, Shahrokhi M, Varacallo M (2023) Naproxen. StatPearls. Treasure Island (FL): StatPearls Publishing.\u00a0Available at: https:\/\/www.statpearls.com"},{"key":"4222_CR19","doi-asserted-by":"publisher","first-page":"259","DOI":"10.5114\/ceji.2017.70968","volume":"42","author":"E Brzustewicz","year":"2017","unstructured":"Brzustewicz E, Henc I, Daca A et al (2017) Autoantibodies, C-reactive protein, erythrocyte sedimentation rate and serum cytokine profiling in monitoring of early treatment. Cent Eur J Immunol 42:259\u2013268. https:\/\/doi.org\/10.5114\/ceji.2017.70968","journal-title":"Cent Eur J Immunol"},{"key":"4222_CR20","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1016\/j.joca.2014.04.031","volume":"22","author":"EF Burguera","year":"2014","unstructured":"Burguera EF, Vela-Anero \u00c1, Magalh\u00e3es J et al (2014) Effect of hydrogen sulfide sources on inflammation and catabolic markers on interleukin 1\u03b2-stimulated human articular chondrocytes. Osteoarthr Cartil 22:1026\u20131035. https:\/\/doi.org\/10.1016\/j.joca.2014.04.031","journal-title":"Osteoarthr Cartil"},{"key":"4222_CR21","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1002\/jcp.21847","volume":"221","author":"C Chavez-Mu\u00f1oz","year":"2009","unstructured":"Chavez-Mu\u00f1oz C, Kilani RT, Ghahary A (2009) Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes. J Cell Physiol 221:221\u2013231. https:\/\/doi.org\/10.1002\/jcp.21847","journal-title":"J Cell Physiol"},{"key":"4222_CR22","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/j.intimp.2015.07.003","volume":"28","author":"S Cheleschi","year":"2015","unstructured":"Cheleschi S, Pascarelli NA, Valacchi G et al (2015) Chondroprotective effect of three different classes of anti-inflammatory agents on human osteoarthritic chondrocytes exposed to IL-1\u03b2. Int Immunopharmacol 28:794\u2013801. https:\/\/doi.org\/10.1016\/j.intimp.2015.07.003","journal-title":"Int Immunopharmacol"},{"key":"4222_CR23","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.2147\/JPR.S132026","volume":"10","author":"E Comi","year":"2017","unstructured":"Comi E, Lanza M, Ferrari F et al (2017) Efficacy of CR4056, a first-in-class imidazoline-2 analgesic drug, in comparison with naproxen in two rat models of osteoarthritis. J Pain Res 10:1033\u20131043. https:\/\/doi.org\/10.2147\/JPR.S132026","journal-title":"J Pain Res"},{"key":"4222_CR24","doi-asserted-by":"publisher","first-page":"3356","DOI":"10.1152\/ajpheart.00928.2007","volume":"293","author":"DM Cortez","year":"2007","unstructured":"Cortez DM, Feldman MD, Mummidi S et al (2007) IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1\/2-dependent C\/EBP-\u03b2, NF-\u03baB, and AP-1 activation. Am J Physiol - Hear Circ Physiol 293:3356\u20133365. https:\/\/doi.org\/10.1152\/ajpheart.00928.2007","journal-title":"Am J Physiol - Hear Circ Physiol"},{"key":"4222_CR25","doi-asserted-by":"crossref","unstructured":"Crofford LJ (2013) Prostanoid biology and its therapeutic targeting. In: Budd RC, Gabriel SE, Firestein GS (eds) Kelley's Textbook of Rheumatology, 9th ed. Philadelphia, PA: W. B. Saunders. pp 871\u2013893.e3","DOI":"10.1016\/B978-1-4377-1738-9.00059-1"},{"key":"4222_CR26","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s12967-021-02822-5","volume":"19","author":"N Cuesta-Gomez","year":"2021","unstructured":"Cuesta-Gomez N, Graham GJ, Campbell JDM (2021) Chemokines and their receptors: predictors of the therapeutic potential of mesenchymal stromal cells. J Transl Med 19:156. https:\/\/doi.org\/10.1186\/s12967-021-02822-5","journal-title":"J Transl Med"},{"key":"4222_CR27","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1189\/jlb.0907654","volume":"83","author":"TM Cunha","year":"2008","unstructured":"Cunha TM, Verri WA, Schivo IR et al (2008) Crucial role of neutrophils in the development of mechanical inflammatory hypernociception. J Leukoc Biol 83:824\u2013832. https:\/\/doi.org\/10.1189\/jlb.0907654","journal-title":"J Leukoc Biol"},{"key":"4222_CR28","doi-asserted-by":"publisher","first-page":"S196","DOI":"10.1016\/S0016-5085(16)30736-3","volume":"150","author":"M Dave","year":"2016","unstructured":"Dave M, Di Martino L, Somoza R et al (2016) 971c Human bone marrow derived mesenchymal stem cells mediate immunosuppression in vitro and in experimental Crohn\u2019s disease. Gastroenterology 150:S196. https:\/\/doi.org\/10.1016\/S0016-5085(16)30736-3","journal-title":"Gastroenterology"},{"key":"4222_CR29","first-page":"1537","volume":"19","author":"AE Dief","year":"2015","unstructured":"Dief AE, Mostafa DK, Sharara GM, Zeitoun TH (2015) Hydrogen sulfide releasing naproxen offers better anti-inflammatory and chondroprotective effect relative to naproxen in a rat model of zymosan induced arthritis. Eur Rev Med Pharmacol Sci 19:1537\u20131546","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"4222_CR30","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/14653240600855905","volume":"8","author":"M Dominici","year":"2006","unstructured":"Dominici M, Le Blanc K, Mueller I et al (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8:315\u2013317. https:\/\/doi.org\/10.1080\/14653240600855905","journal-title":"Cytotherapy"},{"key":"4222_CR31","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1111\/j.1476-5381.2010.00640.x","volume":"159","author":"E Ekundi-Valentim","year":"2010","unstructured":"Ekundi-Valentim E, Santos KT, Camargo EA et al (2010) Differing effects of exogenous and endogenous hydrogen sulphide in carrageenan-induced knee joint synovitis in the rat: research paper. Br J Pharmacol 159:1463\u20131474. https:\/\/doi.org\/10.1111\/j.1476-5381.2010.00640.x","journal-title":"Br J Pharmacol"},{"key":"4222_CR32","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s10238-013-0248-3","volume":"14","author":"ESM El-Denshary","year":"2014","unstructured":"El-Denshary ESM, Rashed LA, Elhussiny M (2014) Mesenchymal stromal cells versus betamethasone can dampen disease activity in the collagen arthritis mouse model. Clin Exp Med 14:285\u2013295. https:\/\/doi.org\/10.1007\/s10238-013-0248-3","journal-title":"Clin Exp Med"},{"key":"4222_CR33","doi-asserted-by":"publisher","first-page":"e13050","DOI":"10.1111\/fcp.13050","volume":"39","author":"J Escal","year":"2025","unstructured":"Escal J, Poudret M, Hodin S et al (2025) Long-term evaluation of rheumatoid arthritis activity with erythrocyte methotrexate-polyglutamate 3. Fundam Clin Pharmacol 39:e13050. https:\/\/doi.org\/10.1111\/fcp.13050","journal-title":"Fundam Clin Pharmacol"},{"key":"4222_CR34","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1139\/Y09-039","volume":"87","author":"L Fang","year":"2009","unstructured":"Fang L, Li H, Tang C et al (2009) Hydrogen sulfide attenuates the pathogenesis of pulmonary fibrosis induced by bleomycin in rats. Can J Physiol Pharmacol 87:531\u2013538. https:\/\/doi.org\/10.1139\/Y09-039","journal-title":"Can J Physiol Pharmacol"},{"key":"4222_CR35","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.neuint.2013.11.002","volume":"64","author":"WJ Feng","year":"2014","unstructured":"Feng WJ, Yu L, Ning SJ, Gang PH (2014) Role of hydrogen sulfide in secondary neuronal injury. Neurochem Int 64:37\u201347. https:\/\/doi.org\/10.1016\/j.neuint.2013.11.002","journal-title":"Neurochem Int"},{"key":"4222_CR36","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.immuni.2017.02.006","volume":"46","author":"GS Firestein","year":"2017","unstructured":"Firestein GS, McInnes IB (2017) Immunopathogenesis of rheumatoid arthritis. Immunity 46:183\u2013196. https:\/\/doi.org\/10.1016\/j.immuni.2017.02.006","journal-title":"Immunity"},{"key":"4222_CR37","doi-asserted-by":"publisher","first-page":"784","DOI":"10.3390\/cells8080784","volume":"8","author":"X Fu","year":"2019","unstructured":"Fu X, Liu G, Halim A et al (2019) Mesenchymal stem cell migration and tissue repair. Cells 8:784. https:\/\/doi.org\/10.3390\/cells8080784","journal-title":"Cells"},{"key":"4222_CR38","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.phrs.2014.06.014","volume":"87","author":"L Gambari","year":"2014","unstructured":"Gambari L, Lisignoli G, Cattini L et al (2014) Sodium hydrosulfide inhibits the differentiation of osteoclast progenitor cells via NRF2-dependent mechanism. Pharmacol Res 87:99\u2013112. https:\/\/doi.org\/10.1016\/j.phrs.2014.06.014","journal-title":"Pharmacol Res"},{"key":"4222_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/mco2.509","volume":"5","author":"Y Gao","year":"2024","unstructured":"Gao Y, Zhang Y, Liu X (2024) Rheumatoid arthritis: pathogenesis and therapeutic advances. MedComm 5:1\u201324. https:\/\/doi.org\/10.1002\/mco2.509","journal-title":"MedComm"},{"key":"4222_CR40","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s00296-022-05258-2","volume":"43","author":"TA Gheita","year":"2023","unstructured":"Gheita TA, Raafat HA, El-Bakry SA et al (2023) Rheumatoid arthritis study of the Egyptian College of Rheumatology (ECR): nationwide presentation and worldwide stance. Rheumatol Int 43:667\u2013676. https:\/\/doi.org\/10.1007\/s00296-022-05258-2","journal-title":"Rheumatol Int"},{"key":"4222_CR41","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1111\/bph.14587","volume":"176","author":"DW Gilroy","year":"2019","unstructured":"Gilroy DW, Bishop-Bailey D (2019) Lipid mediators in immune regulation and resolution. Br J Pharmacol 176:1009\u20131023. https:\/\/doi.org\/10.1111\/bph.14587","journal-title":"Br J Pharmacol"},{"issue":"Suppl 2","key":"4222_CR42","doi-asserted-by":"publisher","first-page":"ii11","DOI":"10.1093\/rheumatology\/keg327","volume":"42","author":"SR Goldring","year":"2003","unstructured":"Goldring SR (2003) Pathogenesis of bone and cartilage destruction in rheumatoid arthritis. Rheumatology (Oxford) 42(Suppl 2):ii11\u2013ii16. https:\/\/doi.org\/10.1093\/rheumatology\/keg327","journal-title":"Rheumatology (Oxford)"},{"key":"4222_CR43","doi-asserted-by":"publisher","first-page":"116","DOI":"10.5152\/eurasianjmed.2018.0010","volume":"50","author":"C Gunaydin","year":"2018","unstructured":"Gunaydin C, Bilge SS (2018) Effects of nonsteroidal anti-inflammatory drugs at the molecular level. Eurasian J Med 50:116\u2013121. https:\/\/doi.org\/10.5152\/eurasianjmed.2018.0010","journal-title":"Eurasian J Med"},{"key":"4222_CR44","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.ejphar.2014.01.009","volume":"725","author":"C Guo","year":"2014","unstructured":"Guo C, Liang F, Shah Masood W, Yan X (2014) Hydrogen sulfide protected gastric epithelial cell from ischemia\/reperfusion injury by Keap1 s-sulfhydration, MAPK dependent anti-apoptosis and NF-\u03baB dependent anti-inflammation pathway. Eur J Pharmacol 725:70\u201378. https:\/\/doi.org\/10.1016\/j.ejphar.2014.01.009","journal-title":"Eur J Pharmacol"},{"key":"4222_CR45","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.3892\/mmr.2015.3651","volume":"12","author":"Z Guo","year":"2015","unstructured":"Guo Z, Li CS, Wang CM et al (2015) CSE\/H2S system protects mesenchymal stem cells from hypoxia and serum deprivation-induced apoptosis via mitochondrial injury, endoplasmic reticulum stress and PI3K\/Akt activation pathways. Mol Med Rep 12:2128\u20132134. https:\/\/doi.org\/10.3892\/mmr.2015.3651","journal-title":"Mol Med Rep"},{"key":"4222_CR46","doi-asserted-by":"publisher","first-page":"823","DOI":"10.3390\/cells8080823","volume":"8","author":"SM Haikal","year":"2019","unstructured":"Haikal SM, Abdeltawab NF, Rashed LA et al (2019) Combination therapy of mesenchymal stromal cells and interleukin-4 attenuates rheumatoid arthritis in a collagen-induced murine model. Cells 8:823. https:\/\/doi.org\/10.3390\/cells8080823","journal-title":"Cells"},{"key":"4222_CR47","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/s41392-022-00932-0","volume":"7","author":"Y Han","year":"2022","unstructured":"Han Y, Yang J, Fang J et al (2022) The secretion profile of mesenchymal stem cells and potential applications in treating human diseases. Signal Transduct Target Ther 7:92. https:\/\/doi.org\/10.1038\/s41392-022-00932-0","journal-title":"Signal Transduct Target Ther"},{"issue":"5","key":"4222_CR48","doi-asserted-by":"publisher","first-page":"2472","DOI":"10.3390\/ijms22052472","volume":"22","author":"CR Harrell","year":"2021","unstructured":"Harrell CR, Djonov V, Volarevic V (2021) The cross-talk between mesenchymal stem cells and immune cells in tissue repair and regeneration. Int J Mol Sci 22(5):2472","journal-title":"Int J Mol Sci"},{"key":"4222_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2474-13-126","volume":"13","author":"BJ Heard","year":"2012","unstructured":"Heard BJ, Martin L, Rattner JB et al (2012) Matrix metalloproteinase protein expression profiles cannot distinguish between normal and early osteoarthritic synovial fluid. BMC Musculoskelet Disord 13:1. https:\/\/doi.org\/10.1186\/1471-2474-13-126","journal-title":"BMC Musculoskelet Disord"},{"key":"4222_CR50","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1136\/ard.2007.076430","volume":"67","author":"M Hegen","year":"2008","unstructured":"Hegen M, Keith JC Jr, Collins M, Nickerson-Nutter CL (2008) Utility of animal models for identification of potential therapeutics for rheumatoid arthritis. Ann Rheum Dis 67:1505\u20131515. https:\/\/doi.org\/10.1136\/ard.2007.076430","journal-title":"Ann Rheum Dis"},{"key":"4222_CR51","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1111\/j.1471-4159.2006.04283.x","volume":"100","author":"LF Hu","year":"2007","unstructured":"Hu LF, Wong PTH, Moore PK, Bian JS (2007) Hydrogen sulfide attenuates lipopolysaccharide-induced inflammation by inhibition of p38 mitogen-activated protein kinase in microglia. J Neurochem 100:1121\u20131128. https:\/\/doi.org\/10.1111\/j.1471-4159.2006.04283.x","journal-title":"J Neurochem"},{"key":"4222_CR52","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1152\/ajplung.00144.2011","volume":"303","author":"L Ionescu","year":"2012","unstructured":"Ionescu L, Byrne RN, van Haaften T et al (2012) Stem cell conditioned medium improves acute lung injury in mice: in vivo evidence for stem cell paracrine action. Am J Physiol - Lung Cell Mol Physiol 303:967\u2013977. https:\/\/doi.org\/10.1152\/ajplung.00144.2011","journal-title":"Am J Physiol - Lung Cell Mol Physiol"},{"key":"4222_CR53","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s12974-020-1703-1","volume":"17","author":"Y Jang","year":"2020","unstructured":"Jang Y, Kim M, Hwang SW (2020) Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception. J Neuroinflammation 17:30. https:\/\/doi.org\/10.1186\/s12974-020-1703-1","journal-title":"J Neuroinflammation"},{"key":"4222_CR54","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1097\/ALN.0000000000002130","volume":"129","author":"R-R Ji","year":"2018","unstructured":"Ji R-R, Nackley A, Huh Y et al (2018) Neuroinflammation and central sensitization in chronic and widespread pain. Anesthesiology 129:343\u2013366. https:\/\/doi.org\/10.1097\/ALN.0000000000002130","journal-title":"Anesthesiology"},{"key":"4222_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/cpr.12712","volume":"53","author":"W Jiang","year":"2020","unstructured":"Jiang W, Xu J (2020) Immune modulation by mesenchymal stem cells. Cell Prolif 53:1\u201316. https:\/\/doi.org\/10.1111\/cpr.12712","journal-title":"Cell Prolif"},{"key":"4222_CR56","doi-asserted-by":"publisher","first-page":"4754","DOI":"10.1038\/s41598-022-08398-4","volume":"12","author":"Q-H Jin","year":"2022","unstructured":"Jin Q-H, Kim H-K, Na J-Y et al (2022) Anti-inflammatory effects of mesenchymal stem cell-conditioned media inhibited macrophages activation in vitro. Sci Rep 12:4754. https:\/\/doi.org\/10.1038\/s41598-022-08398-4","journal-title":"Sci Rep"},{"key":"4222_CR57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13075-019-1819-9","volume":"21","author":"A Katri","year":"2019","unstructured":"Katri A, Dabrowska A, L\u00f6fvall H et al (2019) Combining naproxen and a dual amylin and calcitonin receptor agonist improves pain and structural outcomes in the collagen-induced arthritis rat model. Arthritis Res Ther 21:1\u201311. https:\/\/doi.org\/10.1186\/s13075-019-1819-9","journal-title":"Arthritis Res Ther"},{"key":"4222_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13075-015-0563-z","volume":"17","author":"KW Kim","year":"2015","unstructured":"Kim KW, Kim BM, Moon HW et al (2015) Role of C-reactive protein in osteoclastogenesis in rheumatoid arthritis. Arthritis Res Ther 17:1\u201312. https:\/\/doi.org\/10.1186\/s13075-015-0563-z","journal-title":"Arthritis Res Ther"},{"key":"4222_CR59","doi-asserted-by":"publisher","first-page":"3499","DOI":"10.4049\/jimmunol.166.5.3499","volume":"166","author":"SH Kim","year":"2001","unstructured":"Kim SH, Kim S, Evans CH et al (2001) Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4. J Immunol 166:3499\u20133505. https:\/\/doi.org\/10.4049\/jimmunol.166.5.3499","journal-title":"J Immunol"},{"key":"4222_CR60","first-page":"225","volume":"32","author":"WU Kim","year":"2005","unstructured":"Kim WU, Kim KJ (2005) T cell proliferative response to type II collagen in the inflammatory process and joint damage in patients with rheumatoid arthritis. J Rheumatol 32:225\u2013230","journal-title":"J Rheumatol"},{"key":"4222_CR61","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.neuint.2013.09.003","volume":"63","author":"H Kimura","year":"2013","unstructured":"Kimura H (2013) Physiological role of hydrogen sulfide and polysulfide in the central nervous system. Neurochem Int 63:492\u2013497. https:\/\/doi.org\/10.1016\/j.neuint.2013.09.003","journal-title":"Neurochem Int"},{"key":"4222_CR62","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1042\/CBI20090436","volume":"34","author":"B Kloesch","year":"2010","unstructured":"Kloesch B, Liszt M, Broell J (2010) H2S transiently blocks IL-6 expression in rheumatoid arthritic fibroblast-like synoviocytes and deactivates p44\/42 mitogen-activated protein kinase. Cell Biol Int 34:477\u2013484. https:\/\/doi.org\/10.1042\/CBI20090436","journal-title":"Cell Biol Int"},{"key":"4222_CR63","doi-asserted-by":"publisher","first-page":"23","DOI":"10.12701\/jyms.2022.00773","volume":"40","author":"JS Kong","year":"2023","unstructured":"Kong JS, Jeong GH, Yoo SA (2023) The use of animal models in rheumatoid arthritis research. J Yeungnam Med Sci 40:23\u201329. https:\/\/doi.org\/10.12701\/jyms.2022.00773","journal-title":"J Yeungnam Med Sci"},{"key":"4222_CR64","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1172\/JCI11176","volume":"106","author":"J Lam","year":"2000","unstructured":"Lam J, Takeshita S, Barker JE et al (2000) TNF-\u03b1 induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J Clin Invest 106:1481\u20131488. https:\/\/doi.org\/10.1172\/JCI11176","journal-title":"J Clin Invest"},{"key":"4222_CR65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0193086","volume":"13","author":"K Lee","year":"2018","unstructured":"Lee K, Park N, Jung H et al (2018) Mesenchymal stem cells ameliorate experimental arthritis via expression of interleukin-1 receptor antagonist. PLoS ONE 13:1\u201314. https:\/\/doi.org\/10.1371\/journal.pone.0193086","journal-title":"PLoS ONE"},{"key":"4222_CR66","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-024-01376-y","author":"SY Lee","year":"2025","unstructured":"Lee SY, Moon J, Lee AR et al (2025) mtSTAT3 suppresses rheumatoid arthritis by regulating Th17 and synovial fibroblast inflammatory cell death with IL-17-mediated autophagy dysfunction. Exp Mol Med. https:\/\/doi.org\/10.1038\/s12276-024-01376-y","journal-title":"Exp Mol Med"},{"key":"4222_CR67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/advs.202305116","volume":"11","author":"C Li","year":"2024","unstructured":"Li C, Sun Y, Xu W et al (2024) Mesenchymal stem cells-involved strategies for rheumatoid arthritis therapy. Adv Sci 11:1\u201323. https:\/\/doi.org\/10.1002\/advs.202305116","journal-title":"Adv Sci"},{"key":"4222_CR68","doi-asserted-by":"publisher","first-page":"514898","DOI":"10.1155\/2014\/514898","volume":"2014","author":"J-Q Lin","year":"2014","unstructured":"Lin J-Q, Luo H-Q, Lin C-Z et al (2014) Sodium hydrosulfide relieves neuropathic pain in chronic constriction injured rats. Evid Based Complement Alternat Med 2014:514898. https:\/\/doi.org\/10.1155\/2014\/514898","journal-title":"Evid Based Complement Alternat Med"},{"key":"4222_CR69","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.pop.2018.02.010","volume":"45","author":"EA Littlejohn","year":"2018","unstructured":"Littlejohn EA, Monrad SU (2018) Early diagnosis and treatment of rheumatoid arthritis. Prim Care Clin Off Pract 45:237\u2013255. https:\/\/doi.org\/10.1016\/j.pop.2018.02.010","journal-title":"Prim Care Clin Off Pract"},{"key":"4222_CR70","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.pbb.2013.11.009","volume":"116","author":"D Liu","year":"2014","unstructured":"Liu D, Wang Z, Zhan J et al (2014) Hydrogen sulfide promotes proliferation and neuronal differentiation of neural stem cells and protects hypoxia-induced decrease in hippocampal neurogenesis. Pharmacol Biochem Behav 116:55\u201363. https:\/\/doi.org\/10.1016\/j.pbb.2013.11.009","journal-title":"Pharmacol Biochem Behav"},{"key":"4222_CR71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/ar3187","volume":"12","author":"Y Liu","year":"2010","unstructured":"Liu Y, Mu R, Wang S et al (2010) Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis. Arthritis Res Ther 12:1\u201313. https:\/\/doi.org\/10.1186\/ar3187","journal-title":"Arthritis Res Ther"},{"key":"4222_CR72","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1007\/s11626-013-9725-y","volume":"51","author":"Z Liu","year":"2015","unstructured":"Liu Z, Wang W, Gao J et al (2015) Isolation, culture, and induced multiple differentiation of Mongolian sheep bone marrow-derived mesenchymal stem cells. Vitr Cell Dev Biol - Anim 51:464\u2013474. https:\/\/doi.org\/10.1007\/s11626-013-9725-y","journal-title":"Vitr Cell Dev Biol - Anim"},{"key":"4222_CR73","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"4222_CR74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/sji.12757","volume":"89","author":"H Ma","year":"2019","unstructured":"Ma H, Xu M, Song Y et al (2019) Interferon-\u03b3 facilitated adjuvant-induced arthritis at early stage. Scand J Immunol 89:1\u20138. https:\/\/doi.org\/10.1111\/sji.12757","journal-title":"Scand J Immunol"},{"key":"4222_CR75","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-023-01262-5","author":"R Makkar","year":"2023","unstructured":"Makkar R, Sehgal A, Singh S et al (2023) Current trends in epigenetic, cellular and molecular pathways in management of rheumatoid arthritis. Inflammopharmacology. https:\/\/doi.org\/10.1007\/s10787-023-01262-5","journal-title":"Inflammopharmacology"},{"key":"4222_CR76","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s00011-009-0090-y","volume":"59","author":"F Mao","year":"2010","unstructured":"Mao F, Xu WR, Qian H et al (2010) Immunosuppressive effects of mesenchymal stem cells in collagen-induced mouse arthritis. Inflamm Res 59:219\u2013225. https:\/\/doi.org\/10.1007\/s00011-009-0090-y","journal-title":"Inflamm Res"},{"key":"4222_CR77","doi-asserted-by":"publisher","first-page":"2925","DOI":"10.3389\/fimmu.2019.02925","volume":"10","author":"A Marahleh","year":"2019","unstructured":"Marahleh A, Kitaura H, Ohori F et al (2019) TNF-\u03b1 directly enhances osteocyte RANKL expression and promotes osteoclast formation. Front Immunol 10:2925. https:\/\/doi.org\/10.3389\/fimmu.2019.02925","journal-title":"Front Immunol"},{"key":"4222_CR78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/iid3.1091","volume":"11","author":"MZ Moghaddam","year":"2023","unstructured":"Moghaddam MZ, Mousavi MJ, Ghotloo S (2023) Cell-based therapies for the treatment of rheumatoid arthritis. Immunity, Inflamm Dis 11:1\u201325. https:\/\/doi.org\/10.1002\/iid3.1091","journal-title":"Immunity, Inflamm Dis"},{"issue":"1","key":"4222_CR79","doi-asserted-by":"publisher","first-page":"31","DOI":"10.4103\/JMAU.JMAU_2_20","volume":"9","author":"A Mostafa","year":"2021","unstructured":"Mostafa A, Korayem HE, Fekry E, Hosny S (2021) The effect of intra-articular versus intravenous injection of mesenchymal stem cells on experimentally-induced knee joint osteoarthritis. J Microsc Ultrastruct 9(1):31\u20138","journal-title":"J Microsc Ultrastruct"},{"key":"4222_CR80","doi-asserted-by":"publisher","first-page":"19","DOI":"10.14715\/cmb\/2018.64.2.5","volume":"64","author":"V Nazemian","year":"2018","unstructured":"Nazemian V, Manaheji H, Sharifi AM, Zaringhalam J (2018) Long term treatment by mesenchymal stem cells conditioned medium modulates cellular, molecular and behavioral aspects of adjuvant-induced arthritis Vida. Cell Mol Biol 64:19\u201326","journal-title":"Cell Mol Biol"},{"key":"4222_CR81","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/clim.2002.5210","volume":"104","author":"MM Newkirk","year":"2002","unstructured":"Newkirk MM (2002) Rheumatoid factors: host resistance or autoimmunity? Clin Immunol 104:1\u201313. https:\/\/doi.org\/10.1006\/clim.2002.5210","journal-title":"Clin Immunol"},{"key":"4222_CR82","doi-asserted-by":"publisher","first-page":"225","DOI":"10.4049\/jimmunol.1900172","volume":"203","author":"M Newling","year":"2019","unstructured":"Newling M, Sritharan L, van der Ham AJ et al (2019) C-reactive protein promotes inflammation through Fc\u03b3R-induced glycolytic reprogramming of human macrophages. J Immunol 203:225\u2013235. https:\/\/doi.org\/10.4049\/jimmunol.1900172","journal-title":"J Immunol"},{"key":"4222_CR83","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1002\/jcb.22399","volume":"109","author":"M Ohishi","year":"2010","unstructured":"Ohishi M, Schipani E (2010) Bone marrow mesenchymal stem cells. J Cell Biochem 109:277\u2013282. https:\/\/doi.org\/10.1002\/jcb.22399","journal-title":"J Cell Biochem"},{"key":"4222_CR84","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fvets.2021.617789","volume":"8","author":"C Orhan","year":"2021","unstructured":"Orhan C, Juturu V, Sahin E et al (2021) Undenatured type II collagen ameliorates inflammatory responses and articular cartilage damage in the rat model of osteoarthritis. Front Vet Sci 8:1\u201312. https:\/\/doi.org\/10.3389\/fvets.2021.617789","journal-title":"Front Vet Sci"},{"key":"4222_CR85","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmed.2018.00185","volume":"5","author":"CK Orr","year":"2018","unstructured":"Orr CK, Najm A, Young F et al (2018) The utility and limitations of CRP, ESR and DAS28-CRP in appraising disease activity in rheumatoid arthritis. Front Med 5:1\u20138. https:\/\/doi.org\/10.3389\/fmed.2018.00185","journal-title":"Front Med"},{"key":"4222_CR86","doi-asserted-by":"publisher","unstructured":"Othman ZA, Zakaria Z, Suleiman JB et al (2021) Anti-atherogenic effects of orlistat on obesity-induced vascular oxidative stress rat model. Antioxidants (Basel, Switzerland) 10. https:\/\/doi.org\/10.3390\/antiox10020251","DOI":"10.3390\/antiox10020251"},{"key":"4222_CR87","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1002\/jor.24937","volume":"39","author":"DN Paglia","year":"2021","unstructured":"Paglia DN, Kanjilal D, Kadkoy Y et al (2021) Naproxen treatment inhibits articular cartilage loss in a rat model of osteoarthritis. J Orthop Res 39:2252\u20132259. https:\/\/doi.org\/10.1002\/jor.24937","journal-title":"J Orthop Res"},{"key":"4222_CR88","first-page":"194","volume":"48","author":"LP Pan","year":"2016","unstructured":"Pan LP, Cao YP, Wen LC et al (2016) Hydrogen sulfide in cartilage and its inhibitory effect on matrix metalloproteinase 13 expression in chondrocytes induced by interlukin-1\u03b2. Beijing da xue xue bao Yi xue ban = J Peking Univ Heal Sci 48:194\u2013202","journal-title":"Beijing da xue xue bao Yi xue ban = J Peking Univ Heal Sci"},{"key":"4222_CR89","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1007\/BF03022619","volume":"53","author":"HJ Park","year":"2006","unstructured":"Park HJ, Lee Y, Lee J et al (2006) The effects of botulinum toxin A on mechanical and cold allodynia in a rat model of neuropathic pain. Can J Anaesth 53:470\u2013477. https:\/\/doi.org\/10.1007\/BF03022619","journal-title":"Can J Anaesth"},{"key":"4222_CR90","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.3727\/096368915X687949","volume":"25","author":"KH Park","year":"2016","unstructured":"Park KH, Mun CH, Il KM et al (2016) Treatment of collagen-induced arthritis using immune modulatory properties of human mesenchymal stem cells. Cell Transplant 25:1057\u20131072. https:\/\/doi.org\/10.3727\/096368915X687949","journal-title":"Cell Transplant"},{"key":"4222_CR91","first-page":"393","volume":"15","author":"JP Pelletier","year":"1997","unstructured":"Pelletier JP, Mineau F, Fernandes J et al (1997) Two NSAIDs, nimesulide and naproxen, can reduce the synthesis of urokinase and IL-6 while increasing PAI-1, in human OA synovial fibroblasts. Clin Exp Rheumatol 15:393\u2013398","journal-title":"Clin Exp Rheumatol"},{"key":"4222_CR92","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.it.2016.10.001","volume":"38","author":"FA Pinho-Ribeiro","year":"2017","unstructured":"Pinho-Ribeiro FA, Verri WA Jr, Chiu IM (2017) Nociceptor sensory neuron\u2013immune interactions in pain and inflammation. Trends Immunol 38:5\u201319. https:\/\/doi.org\/10.1016\/j.it.2016.10.001","journal-title":"Trends Immunol"},{"key":"4222_CR93","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/357014","volume":"2013","author":"J Platas","year":"2013","unstructured":"Platas J, Guill\u00e9n MI, Del Caz MDP et al (2013) Conditioned media from adipose-tissue-derived mesenchymal stem cells downregulate degradative mediators induced by interleukin-1 \u03b2 in osteoarthritic chondrocytes. Mediators Inflamm 2013:1. https:\/\/doi.org\/10.1155\/2013\/357014","journal-title":"Mediators Inflamm"},{"key":"4222_CR94","doi-asserted-by":"publisher","first-page":"4486","DOI":"10.1182\/blood.v114.22.4486.4486","volume":"114","author":"Z Qiao","year":"2009","unstructured":"Qiao Z, Ma L (2009) Study on mechanism of bone marrow mesenchymal stem cell in treating patients with rheumatoid arthritis. Blood 114:4486\u20134486. https:\/\/doi.org\/10.1182\/blood.v114.22.4486.4486","journal-title":"Blood"},{"key":"4222_CR95","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1478-811X-9-23","volume":"9","author":"J Rauch","year":"2011","unstructured":"Rauch J, Volinsky N, Romano D, Kolch W (2011) The secret life of kinases: functions beyond catalysis. Cell Commun Signal 9:23. https:\/\/doi.org\/10.1186\/1478-811X-9-23","journal-title":"Cell Commun Signal"},{"key":"4222_CR96","doi-asserted-by":"publisher","unstructured":"Sadowski T, Steinmeyer J (2001) Effects of non-steroidal antiinflammatory drugs and dexamethasone on the activity and expression of matrix metalloproteinase-1, matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 by bovine articular chondrocytes 9:407\u2013415. https:\/\/doi.org\/10.1053\/joca.2000.0406","DOI":"10.1053\/joca.2000.0406"},{"key":"4222_CR97","doi-asserted-by":"publisher","first-page":"1463 LP","DOI":"10.1136\/annrheumdis-2019-215920","volume":"78","author":"S Safiri","year":"2019","unstructured":"Safiri S, Kolahi AA, Hoy D et al (2019) Global, regional and national burden of rheumatoid arthritis 1990\u20132017: a systematic analysis of the Global Burden of Disease study 2017. Ann Rheum Dis 78:1463 LP \u2013 1471. https:\/\/doi.org\/10.1136\/annrheumdis-2019-215920","journal-title":"Ann Rheum Dis"},{"key":"4222_CR98","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.medcle.2014.01.006","volume":"144","author":"I S\u00e1nchez-Bern\u00e1","year":"2015","unstructured":"S\u00e1nchez-Bern\u00e1 I, Santiago-D\u00edaz C, Jim\u00e9nez-Alonso J (2015) Immunomodulatory properties of stem mesenchymal cells in autoimmune diseases. Med Cl\u00ednica English Ed 144:88\u201391. https:\/\/doi.org\/10.1016\/j.medcle.2014.01.006","journal-title":"Med Cl\u00ednica English Ed"},{"key":"4222_CR99","doi-asserted-by":"publisher","unstructured":"Sarsenova M, Issabekova A, Abisheva S et al (2021a) Mesenchymal stem cell-based therapy for rheumatoid arthritis. Int J Mol Sci 22. https:\/\/doi.org\/10.3390\/ijms222111592","DOI":"10.3390\/ijms222111592"},{"key":"4222_CR100","doi-asserted-by":"publisher","unstructured":"Sarsenova M, Issabekova A, Abisheva S et al (2021b) Mesenchymal stem cell-based therapy for rheumatoid arthritis. Int J Mol Sci 22:1592. https:\/\/doi.org\/10.3390\/ijms222111592","DOI":"10.3390\/ijms222111592"},{"key":"4222_CR101","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.molcel.2011.10.021","volume":"45","author":"N Sen","year":"2012","unstructured":"Sen N, Paul BD, Gadalla MM et al (2012) Hydrogen sulfide-linked sulfhydration of NF- k B mediates its antiapoptotic actions. Mol Cell 45:13\u201324. https:\/\/doi.org\/10.1016\/j.molcel.2011.10.021","journal-title":"Mol Cell"},{"key":"4222_CR102","first-page":"1","volume":"2018","author":"B Shi","year":"2018","unstructured":"Shi B, Qi J, Yao G (2018) MSC transplantation ameliorates Sj\u00f6gren\u2019s syndrome via suppressing IL-12 production by DC. Stem Cell Res Ther 2018:1\u201310","journal-title":"Stem Cell Res Ther"},{"key":"4222_CR103","doi-asserted-by":"publisher","first-page":"684","DOI":"10.4252\/wjsc.v14.i9.684","volume":"14","author":"M-Y Shi","year":"2022","unstructured":"Shi M-Y, Liu L, Yang F-Y (2022) Strategies to improve the effect of mesenchymal stem cell therapy on inflammatory bowel disease. World J Stem Cells 14:684\u2013699. https:\/\/doi.org\/10.4252\/wjsc.v14.i9.684","journal-title":"World J Stem Cells"},{"key":"4222_CR104","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/jcmm.12405","volume":"19","author":"D Sieghart","year":"2015","unstructured":"Sieghart D, Liszt M, Wanivenhaus A et al (2015) Hydrogen sulphide decreases IL-1\u03b2-induced activation of fibroblast-like synoviocytes from patients with osteoarthritis. J Cell Mol Med 19:187\u2013197. https:\/\/doi.org\/10.1111\/jcmm.12405","journal-title":"J Cell Mol Med"},{"key":"4222_CR105","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","volume":"388","author":"JS Smolen","year":"2016","unstructured":"Smolen JS, Aletaha D, McInnes IB (2016) Rheumatoid arthritis. Lancet 388:2023\u20132038. https:\/\/doi.org\/10.1016\/S0140-6736(16)30173-8","journal-title":"Lancet"},{"key":"4222_CR106","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2018.00754","volume":"9","author":"NR Sproston","year":"2018","unstructured":"Sproston NR, Ashworth JJ (2018) Role of C-reactive protein at sites of inflammation and infection. Front Immunol 9:1\u201311. https:\/\/doi.org\/10.3389\/fimmu.2018.00754","journal-title":"Front Immunol"},{"key":"4222_CR107","unstructured":"Stevens A, Bancroft JD (1996) Theory and practice of histological techniques, 4th edn.\u00a0Edinburgh: Churchill Livingstone"},{"key":"4222_CR108","doi-asserted-by":"publisher","first-page":"3511","DOI":"10.1002\/art.34644","volume":"64","author":"S Tarp","year":"2012","unstructured":"Tarp S, Bartels EM, Bliddal H et al (2012) Effect of nonsteroidal antiinflammatory drugs on the C-reactive protein level in rheumatoid arthritis: a meta-analysis of randomized controlled trials. Arthritis Rheum 64:3511\u20133521. https:\/\/doi.org\/10.1002\/art.34644","journal-title":"Arthritis Rheum"},{"key":"4222_CR109","doi-asserted-by":"publisher","first-page":"2923","DOI":"10.12659\/MSM.911184","volume":"25","author":"S Tian","year":"2019","unstructured":"Tian S, Yan Y, Qi X et al (2019) Treatment of type ii collagen-induced rat rheumatoid arthritis model by interleukin 10 (IL10)-mesenchymal stem cells (BMSCs). Med Sci Monit 25:2923\u20132934. https:\/\/doi.org\/10.12659\/MSM.911184","journal-title":"Med Sci Monit"},{"key":"4222_CR110","doi-asserted-by":"publisher","first-page":"954 LP","DOI":"10.1136\/annrheumdis-2015-eular.5241","volume":"74","author":"S Vagnani","year":"2015","unstructured":"Vagnani S, Tani C, Carli L et al (2015) AB0190 treatment with bone marrow mesenchymal stromal cells in a murine model of systemic lupus erythematosus. Ann Rheum Dis 74:954 LP \u2013 954. https:\/\/doi.org\/10.1136\/annrheumdis-2015-eular.5241","journal-title":"Ann Rheum Dis"},{"key":"4222_CR111","doi-asserted-by":"publisher","first-page":"102392","DOI":"10.1016\/j.jaut.2019.102392","volume":"110","author":"MAM van Delft","year":"2020","unstructured":"van Delft MAM, Huizinga TWJ (2020) An overview of autoantibodies in rheumatoid arthritis. J Autoimmun 110:102392. https:\/\/doi.org\/10.1016\/j.jaut.2019.102392","journal-title":"J Autoimmun"},{"key":"4222_CR112","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.niox.2017.08.004","volume":"70","author":"T Vela-Anero","year":"2017","unstructured":"Vela-Anero T, Hermida-G\u00f3mez T, Gato-Calvo L et al (2017) Long-term effects of hydrogen sulfide on the anabolic-catabolic balance of articular cartilage in vitro. Nitric Oxide - Biol Chem 70:42\u201350. https:\/\/doi.org\/10.1016\/j.niox.2017.08.004","journal-title":"Nitric Oxide - Biol Chem"},{"key":"4222_CR113","doi-asserted-by":"publisher","unstructured":"Wang B, Shao Z, Gu M et al (2021a) Hydrogen sulfide protects against IL-1\u03b2-induced inflammation and mitochondrial dysfunction-related apoptosis in chondrocytes and ameliorates osteoarthritis. J Cell Physiol 236:4369\u20134386. https:\/\/doi.org\/10.1002\/jcp.30154","DOI":"10.1002\/jcp.30154"},{"key":"4222_CR114","first-page":"1","volume":"62","author":"C Wang","year":"2016","unstructured":"Wang C, Zhang T, Liu W et al (2016) Sox9-induced chondrogenesis in mesenchymal stem cells was mediated by ERK5 signal pathway. Cell Mol Biol (Noisy-le-grand) 62:1\u20137","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"4222_CR115","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1111\/1756-185X.13921","volume":"23","author":"D Wang","year":"2020","unstructured":"Wang D, Cui Y, Lei H et al (2020) Diagnostic accuracy of 14\u20133-3 \u03b7 protein in rheumatoid arthritis: a meta-analysis. Int J Rheum Dis 23:1443\u20131451. https:\/\/doi.org\/10.1111\/1756-185X.13921","journal-title":"Int J Rheum Dis"},{"key":"4222_CR116","doi-asserted-by":"publisher","unstructured":"Wang H, Zhang N, Fang K, Chang X (2021b) 2-Deoxy-D-glucose alleviates collagen-induced arthritis of rats and is accompanied by metabolic regulation of the spleen and liver. Front Immunol 12:1\u201319. https:\/\/doi.org\/10.3389\/fimmu.2021.713799","DOI":"10.3389\/fimmu.2021.713799"},{"key":"4222_CR117","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1152\/physrev.00017.2011","volume":"92","author":"R Wang","year":"2012","unstructured":"Wang R (2012) Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. Physiol Rev 92:791\u2013896. https:\/\/doi.org\/10.1152\/physrev.00017.2011","journal-title":"Physiol Rev"},{"key":"4222_CR118","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1016\/j.intimp.2004.07.022","volume":"4","author":"YH Wei","year":"2004","unstructured":"Wei YH, Li Y, Qiang CJ (2004) Effects and mechanisms of FR167653, a dual inhibitor of interleukin-1 and tumor necrosis factor, on adjuvant arthritis in rats. Int Immunopharmacol 4:1625\u20131632. https:\/\/doi.org\/10.1016\/j.intimp.2004.07.022","journal-title":"Int Immunopharmacol"},{"issue":"1\u20132","key":"4222_CR119","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0022-510X(00)00386-5","volume":"179","author":"BC White","year":"2000","unstructured":"White BC, Sullivan JM, DeGracia DJ et al (2000) Brain ischemia and reperfusion: molecular mechanisms of neuronal injury. J Neurol Sci 179(1\u20132):1\u201333","journal-title":"J Neurol Sci"},{"key":"4222_CR120","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1089\/ars.2009.2899","volume":"12","author":"M Whiteman","year":"2010","unstructured":"Whiteman M, Li L, Rose P et al (2010) The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages. Antioxidants Redox Signal 12:1147\u20131154. https:\/\/doi.org\/10.1089\/ars.2009.2899","journal-title":"Antioxidants Redox Signal"},{"key":"4222_CR121","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.redox.2016.08.011","volume":"10","author":"WJ Wu","year":"2016","unstructured":"Wu WJ, Jia WW, Liu XH et al (2016) S-propargyl-cysteine attenuates inflammatory response in rheumatoid arthritis by modulating the Nrf2-ARE signaling pathway. Redox Biol 10:157\u2013167. https:\/\/doi.org\/10.1016\/j.redox.2016.08.011","journal-title":"Redox Biol"},{"key":"4222_CR122","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1620\/tjem.226.29","volume":"226","author":"X Xie","year":"2012","unstructured":"Xie X, Sun A, Zhu W et al (2012) Transplantation of mesenchymal stem cells preconditioned with hydrogen sulfide enhances repair of myocardial infarction in rats. Tohoku J Exp Med 226:29\u201336. https:\/\/doi.org\/10.1620\/tjem.226.29","journal-title":"Tohoku J Exp Med"},{"key":"4222_CR123","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.3390\/ijms19082164","volume":"19","author":"MF Yam","year":"2018","unstructured":"Yam MF, Loh YC, Tan CS et al (2018) General pathways of pain sensation and the major neurotransmitters involved in pain regulation. Int J Mol Sci 19:2164. https:\/\/doi.org\/10.3390\/ijms19082164","journal-title":"Int J Mol Sci"},{"key":"4222_CR124","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.jneuroim.2010.07.013","volume":"227","author":"B Yamout","year":"2010","unstructured":"Yamout B, Hourani R, Salti H et al (2010) Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: a pilot study. J Neuroimmunol 227:185\u2013189. https:\/\/doi.org\/10.1016\/j.jneuroim.2010.07.013","journal-title":"J Neuroimmunol"},{"key":"4222_CR125","doi-asserted-by":"publisher","first-page":"693","DOI":"10.3727\/096368910X550198","volume":"20","author":"TL Yew","year":"2011","unstructured":"Yew TL, Hung YT, Li HY et al (2011) Enhancement of wound healing by human multipotent stromal cell conditioned medium: the paracrine factors and p38 MAPK activation. Cell Transplant 20:693\u2013706. https:\/\/doi.org\/10.3727\/096368910X550198","journal-title":"Cell Transplant"},{"key":"4222_CR126","doi-asserted-by":"publisher","unstructured":"Zhang GY, Lu D, Duan SF et al (2018) Hydrogen sulfide alleviates lipopolysaccharide-induced diaphragm dysfunction in rats by reducing apoptosis and inflammation through ROS\/MAPK and TLR4\/NF-\u03baB signaling pathways. Oxid Med Cell Longev 2018. https:\/\/doi.org\/10.1155\/2018\/9647809","DOI":"10.1155\/2018\/9647809"},{"key":"4222_CR127","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0074422","volume":"8","author":"Q Zhang","year":"2013","unstructured":"Zhang Q, Fu H, Zhang H et al (2013) Hydrogen sulfide preconditioning protects rat liver against ischemia\/reperfusion injury by activating Akt-GSK-3\u03b2 signaling and inhibiting mitochondrial permeability transition. PLoS ONE 8:1\u201312. https:\/\/doi.org\/10.1371\/journal.pone.0074422","journal-title":"PLoS ONE"},{"key":"4222_CR128","doi-asserted-by":"publisher","first-page":"58089","DOI":"10.18632\/oncotarget.11166","volume":"7","author":"Q Zhang","year":"2016","unstructured":"Zhang Q, Liu S, Li T et al (2016) Preconditioning of bone marrow mesenchymal stem cells with hydrogen sulfide improves their therapeutic potential. Oncotarget 7:58089\u201358104. https:\/\/doi.org\/10.18632\/oncotarget.11166","journal-title":"Oncotarget"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04222-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-025-04222-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04222-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T11:15:12Z","timestamp":1761304512000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-025-04222-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,14]]},"references-count":128,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["4222"],"URL":"https:\/\/doi.org\/10.1007\/s00210-025-04222-8","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,14]]},"assertion":[{"value":"14 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were carried out in compliance with the ethical guidelines for the experimental animals and got the approval of the Medical Research Ethics Committee of the National Research Center (NRC), Giza, Egypt (approval no. 20 062), complying with the ARRIVE guidelines and was conducted according to the eighth edition (2011) guidelines of the National Institutes of Health (NIH) for the Care and Use of Experimental Animals (NIH publication no. 8023, revised 1978).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}