{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:29:50Z","timestamp":1790890190903,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s00210-025-04226-4","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:20:26Z","timestamp":1747207226000},"page":"15683-15700","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Apolipoprotein-decorated drug loaded liposomes mitigating copper intoxication: an in vitro and in vivo evidence-based study intervening Wilson disease"],"prefix":"10.1007","volume":"398","author":[{"given":"Akanksha","family":"Chaturvedi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gagandeep","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,14]]},"reference":[{"key":"4226_CR1","first-page":"79","volume":"11","author":"MJ Azmand","year":"2021","unstructured":"Azmand MJ, Rajaei Z (2021) Effects of crocin on spatial or aversive learning and memory impairments induced by lipopolysaccharide in rats. Avicenna J Phytomed 11:79\u201390","journal-title":"Avicenna J Phytomed"},{"key":"4226_CR2","doi-asserted-by":"publisher","unstructured":"Bisht A, Gururani R, Jain S, et al (2023) Cedrus deodara (Roxb. ex D.Don) G.Don bark fraction ameliorates metabolic, endocrine and ovarian dynamics in rats experiencing polycystic ovarian syndrome. J Ethnopharmacol 306:116206. https:\/\/doi.org\/10.1016\/j.jep.2023.116206","DOI":"10.1016\/j.jep.2023.116206"},{"key":"4226_CR3","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.ejpb.2022.02.004","volume":"172","author":"A Brookes","year":"2022","unstructured":"Brookes A, Ji L, Bradshaw TD et al (2022) Is oral lipid-based delivery for drug targeting to the brain feasible? Eur J Pharm Biopharm 172:112\u2013122. https:\/\/doi.org\/10.1016\/j.ejpb.2022.02.004","journal-title":"Eur J Pharm Biopharm"},{"key":"4226_CR4","doi-asserted-by":"crossref","unstructured":"Bruschi ML (2015) Mathematical models of drug release. In: Strategies to modify the drug release from pharmaceutical systems. Elsevier, pp 63\u201386","DOI":"10.1016\/B978-0-08-100092-2.00005-9"},{"key":"4226_CR5","doi-asserted-by":"publisher","first-page":"4240","DOI":"10.1007\/s12035-023-03816-8","volume":"61","author":"A Chaturvedi","year":"2024","unstructured":"Chaturvedi A, Sharma S, Shukla R (2024) Nano-mediated molecular targeting in diagnosis and mitigation of Wilson disease. Mol Neurobiol 61:4240\u20134258. https:\/\/doi.org\/10.1007\/s12035-023-03816-8","journal-title":"Mol Neurobiol"},{"key":"4226_CR6","doi-asserted-by":"publisher","first-page":"79","DOI":"10.7324\/JABB.2018.60613","volume":"6","author":"S Dasari","year":"2018","unstructured":"Dasari S, Ganjayi MS, Gonuguntla S et al (2018) Assessment of biomarkers in acrylamide-induced neurotoxicity and brain histopathology in rat. J Appl Biol Biotechnol 6:79\u201386. https:\/\/doi.org\/10.7324\/JABB.2018.60613","journal-title":"J Appl Biol Biotechnol"},{"issue":"3","key":"4226_CR7","first-page":"217","volume":"67","author":"S Dash","year":"2010","unstructured":"Dash S, Murthy PN, Nath L, Chowdhury P (2010) Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol Pharm 67(3):217\u201323","journal-title":"Acta Pol Pharm"},{"key":"4226_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/1245049","volume":"2016","author":"S Di Meo","year":"2016","unstructured":"Di Meo S, Reed TT, Venditti P, Victor VM (2016) Role of ROS and RNS sources in physiological and pathological conditions. Oxid Med Cell Longev 2016:1\u201344. https:\/\/doi.org\/10.1155\/2016\/1245049","journal-title":"Oxid Med Cell Longev"},{"key":"4226_CR9","doi-asserted-by":"crossref","unstructured":"Du G, Sun X (2023) Ethanol injection method for liposome preparation. pp 65\u201370","DOI":"10.1007\/978-1-0716-2954-3_5"},{"key":"4226_CR10","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-025-04782-z","author":"PR Dubey","year":"2025","unstructured":"Dubey PR, Kaur G, Shukla R (2025) Nano-mediated management of metal toxicity-induced neurodegeneration: a critical review. Mol Neurobiol. https:\/\/doi.org\/10.1007\/s12035-025-04782-z","journal-title":"Mol Neurobiol"},{"key":"4226_CR11","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.jconrel.2022.03.019","volume":"345","author":"M Farshbaf","year":"2022","unstructured":"Farshbaf M, Mojarad-Jabali S, Hemmati S et al (2022) Enhanced BBB and BBTB penetration and improved anti-glioma behavior of Bortezomib through dual-targeting nanostructured lipid carriers. J Control Release 345:371\u2013384. https:\/\/doi.org\/10.1016\/j.jconrel.2022.03.019","journal-title":"J Control Release"},{"key":"4226_CR12","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1111\/j.1742-7843.2011.00836.x","volume":"110","author":"SJS Flora","year":"2012","unstructured":"Flora SJS, Bhadauria S, Pachauri V, Yadav A (2012) Monoisoamyl 2, 3-dimercaptosuccinic acid (MiADMSA) demonstrates higher efficacy by oral route in reversing arsenic toxicity: a pharmacokinetic approach. Basic Clin Pharmacol Toxicol 110:449\u2013459. https:\/\/doi.org\/10.1111\/j.1742-7843.2011.00836.x","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"4226_CR13","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.7460","volume":"7","author":"RZ Hamza","year":"2019","unstructured":"Hamza RZ, Al-Salmi FA, El-Shenawy NS (2019) Evaluation of the effects of the green nanoparticles zinc oxide on monosodium glutamate-induced toxicity in the brain of rats. PeerJ 7:e7460. https:\/\/doi.org\/10.7717\/peerj.7460","journal-title":"PeerJ"},{"key":"4226_CR14","doi-asserted-by":"publisher","first-page":"4714","DOI":"10.1021\/acs.molpharmaceut.3c00454","volume":"20","author":"M Handa","year":"2023","unstructured":"Handa M, Sanap SN, Bhatta RS et al (2023) Simultaneous intranasal codelivery of donepezil and memantine in a nanocolloidal carrier: optimization, pharmacokinetics, and pharmacodynamics studies. Mol Pharm 20:4714\u20134728. https:\/\/doi.org\/10.1021\/acs.molpharmaceut.3c00454","journal-title":"Mol Pharm"},{"key":"4226_CR15","doi-asserted-by":"publisher","first-page":"2626","DOI":"10.1038\/s41380-020-0742-4","volume":"26","author":"M Kahana","year":"2021","unstructured":"Kahana M, Weizman A, Gabay M et al (2021) Liposome-based targeting of dopamine to the brain: a novel approach for the treatment of Parkinson\u2019s disease. Mol Psychiatry 26:2626\u20132632. https:\/\/doi.org\/10.1038\/s41380-020-0742-4","journal-title":"Mol Psychiatry"},{"key":"4226_CR16","doi-asserted-by":"publisher","first-page":"250","DOI":"10.3390\/polym13020250","volume":"13","author":"P Kesharwani","year":"2021","unstructured":"Kesharwani P, Md S, Alhakamy NA et al (2021) QbD enabled azacitidine loaded liposomal nanoformulation and its in vitro evaluation. Polymers (Basel) 13:250. https:\/\/doi.org\/10.3390\/polym13020250","journal-title":"Polymers (Basel)"},{"key":"4226_CR17","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1208\/s12249-023-02684-8","volume":"24","author":"P Khairnar","year":"2023","unstructured":"Khairnar P, Singh A, Ahirwar K, Shukla R (2023) ApoE3 anchored liposomal delivery of rivastigmine for brain delivery: formulation, characterization, and in vivo pharmacokinetic evaluation. AAPS PharmSciTech 24:223. https:\/\/doi.org\/10.1208\/s12249-023-02684-8","journal-title":"AAPS PharmSciTech"},{"key":"4226_CR18","doi-asserted-by":"publisher","unstructured":"Khlifi R, Lahmar A, Dhaouefi Z, et al (2019) Assessment of hypolipidemic, anti-inflammatory and antioxidant properties of medicinal plant Erica multiflora in triton WR-1339-induced hyperlipidemia and liver function repair in rats: a comparison with fenofibrate. Regul Toxicol Pharmacol 107:. https:\/\/doi.org\/10.1016\/J.YRTPH.2019.104404","DOI":"10.1016\/J.YRTPH.2019.104404"},{"key":"4226_CR19","doi-asserted-by":"publisher","first-page":"4124","DOI":"10.1021\/acschemneuro.9b00343","volume":"10","author":"KV Krishna","year":"2019","unstructured":"Krishna KV, Wadhwa G, Alexander A et al (2019) Design and biological evaluation of lipoprotein-based donepezil nanocarrier for enhanced brain uptake through oral delivery. ACS Chem Neurosci 10:4124\u20134135. https:\/\/doi.org\/10.1021\/acschemneuro.9b00343","journal-title":"ACS Chem Neurosci"},{"key":"4226_CR20","doi-asserted-by":"publisher","first-page":"217","DOI":"10.3233\/JHD-160205","volume":"5","author":"A Kumar","year":"2016","unstructured":"Kumar A, Ratan RR (2016) Oxidative stress and Huntington\u2019s disease: the good, the bad, and the ugly. J Huntingtons Dis 5:217\u2013237. https:\/\/doi.org\/10.3233\/JHD-160205","journal-title":"J Huntingtons Dis"},{"key":"4226_CR21","doi-asserted-by":"publisher","first-page":"27","DOI":"10.14715\/cmb\/2019.65.1.5","volume":"65","author":"J Kumar","year":"2019","unstructured":"Kumar J, Sathua KB, Flora SJS (2019) Chronic copper exposure elicit neurotoxic responses in rat brain: assessment of 8-hydroxy-2-deoxyguanosine activity, oxidative stress and neurobehavioral parameters. Cell Mol Biol (Noisy-le-grand) 65:27\u201335","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"4226_CR22","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.3390\/molecules28031514","volume":"28","author":"T Maryam","year":"2023","unstructured":"Maryam T, Rana NF, Alshahrani SM et al (2023) Silymarin encapsulated liposomal formulation: an effective treatment modality against copper toxicity associated liver dysfunction and neurobehavioral abnormalities in Wistar rats. Molecules 28:1514. https:\/\/doi.org\/10.3390\/molecules28031514","journal-title":"Molecules"},{"key":"4226_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174506","volume":"910","author":"N Mohammadi","year":"2021","unstructured":"Mohammadi N, Asle-Rousta M, Rahnema M, Amini R (2021) Morin attenuates memory deficits in a rat model of Alzheimer\u2019s disease by ameliorating oxidative stress and neuroinflammation. Eur J Pharmacol 910:174506. https:\/\/doi.org\/10.1016\/j.ejphar.2021.174506","journal-title":"Eur J Pharmacol"},{"key":"4226_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110871","volume":"132","author":"S Naqvi","year":"2020","unstructured":"Naqvi S, Kumar P, Flora SJS (2020) Comparative efficacy of nano and bulk monoisoamyl DMSA against arsenic-induced neurotoxicity in rats. Biomed Pharmacother 132:110871. https:\/\/doi.org\/10.1016\/j.biopha.2020.110871","journal-title":"Biomed Pharmacother"},{"key":"4226_CR25","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/26\/49\/495103","volume":"26","author":"AR Neves","year":"2015","unstructured":"Neves AR, Queiroz JF, Weksler B et al (2015) Solid lipid nanoparticles as a vehicle for brain-targeted drug delivery: two new strategies of functionalization with apolipoprotein E. Nanotechnology 26:495103. https:\/\/doi.org\/10.1088\/0957-4484\/26\/49\/495103","journal-title":"Nanotechnology"},{"key":"4226_CR26","doi-asserted-by":"publisher","unstructured":"Palassi S, Valizadeh H, Allahyari S, Zakeri-Milani P (2020) Preparation and in-vitro characterization of enoxaparin nano-liposomes through different methods. Adv Pharm Bull. https:\/\/doi.org\/10.34172\/apb.2021.042","DOI":"10.34172\/apb.2021.042"},{"key":"4226_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2020.111692","volume":"145","author":"J Patwa","year":"2020","unstructured":"Patwa J, Flora SJS (2020) MiADMSA abrogates chronic copper-induced hepatic and immunological changes in Sprague Dawley rats. Food Chem Toxicol 145:111692. https:\/\/doi.org\/10.1016\/j.fct.2020.111692","journal-title":"Food Chem Toxicol"},{"key":"4226_CR28","doi-asserted-by":"publisher","first-page":"718","DOI":"10.3390\/toxics10120718","volume":"10","author":"J Patwa","year":"2022","unstructured":"Patwa J, Thakur A, Flora SJS (2022) Alpha lipoic acid and monoisoamyl-DMSA combined treatment ameliorates copper-induced neurobehavioral deficits, oxidative stress, and inflammation. Toxics 10:718. https:\/\/doi.org\/10.3390\/toxics10120718","journal-title":"Toxics"},{"key":"4226_CR29","doi-asserted-by":"crossref","unstructured":"Patwa J, Thakur A, Sharma A, et al (2020) Monoisoamyl DMSA reduced copper-induced neurotoxicity by lowering 8-OHdG level, amyloid beta and Tau protein expressions in Sprague-Dawley rats. academic.oup.comJ Patwa, A Thakur, A Sharma, SJS FloraMetallomics, 2020\u2022academic.oup.com 12:1428\u20131448","DOI":"10.1039\/d0mt00083c"},{"key":"4226_CR30","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1080\/03639045.2023.2185463","volume":"49","author":"GA Reddy","year":"2023","unstructured":"Reddy GA, Handa M, Garabadu D et al (2023) Transferrin decorated PLGA encumbered moxifloxacin nanoparticles and in vitro cellular studies. Drug Dev Ind Pharm 49:129\u2013138. https:\/\/doi.org\/10.1080\/03639045.2023.2185463","journal-title":"Drug Dev Ind Pharm"},{"key":"4226_CR31","doi-asserted-by":"crossref","unstructured":"Shukla R, Singh A, Pardhi V, et al (2019) Dendrimer-based nanoparticulate delivery system for cancer therapy. In: Polymeric nanoparticles as a promising tool for anti-cancer therapeutics. Elsevier, pp 233\u2013255","DOI":"10.1016\/B978-0-12-816963-6.00011-X"},{"key":"4226_CR32","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1016\/j.ijbiomac.2020.02.041","volume":"149","author":"A Singh","year":"2020","unstructured":"Singh A, Kumar A, Verma RK, Shukla R (2020) Silymarin encapsulated nanoliquid crystals for improved activity against beta amyloid induced cytotoxicity. Int J Biol Macromol 149:1198\u20131206. https:\/\/doi.org\/10.1016\/j.ijbiomac.2020.02.041","journal-title":"Int J Biol Macromol"},{"key":"4226_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2022.105193","volume":"244","author":"A Singh","year":"2022","unstructured":"Singh A, Vaish A, Shukla R (2022) Box-Behnken design optimized silibinin loaded glycerylmonooleate nanoliquid crystal for brain targeting. Chem Phys Lipids 244:105193. https:\/\/doi.org\/10.1016\/j.chemphyslip.2022.105193","journal-title":"Chem Phys Lipids"},{"key":"4226_CR34","doi-asserted-by":"publisher","first-page":"4267","DOI":"10.2147\/IJN.S65402","volume":"9","author":"M Tamaru","year":"2014","unstructured":"Tamaru M, Akita H, Nakatani T et al (2014) Application of apolipoprotein E-modified liposomal nanoparticles as a carrier for delivering DNA and nucleic acid in the brain. Int J Nanomedicine 9:4267\u20134276. https:\/\/doi.org\/10.2147\/IJN.S65402","journal-title":"Int J Nanomedicine"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04226-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-025-04226-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04226-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T11:14:42Z","timestamp":1761304482000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-025-04226-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,14]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["4226"],"URL":"https:\/\/doi.org\/10.1007\/s00210-025-04226-4","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,14]]},"assertion":[{"value":"4 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The animals used in the study was approved by Institutional Animal Ethics Committee (IAEC) under approval no. NIPER\/RBL\/IAEC\/181\/Nov. 2023.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All authors who have been involved in completing this manuscript have approved the final version of the manuscript for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}