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Specifically, the Essential items of ARRIVE 2.0 have been addressed, along with the recommended set guidelines. Below is a summary of how we comply with these standards:\n                      \n                      In addition to the Essential 10, we have also adhered to the Recommended Set of ARRIVE 2.0 items, including detailed descriptions of animal housing, care, welfare considerations, and environmental conditions, as outlined in by CCSEA, India, and ARRIVE 2.0 mentioned in \u201c\n                      In-Vivo\n                      approach section of Methodology\u201d in our manuscript.We are confident that our manuscript adheres to CCSEA, India, regulations and matches Essential 10 and Recommended Set of ARRIVE 2.0 guidelines covered, ensuring that our research is reported with the necessary rigor, transparency, and reproducibility.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}