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We measured the force of contraction on paced (1\u00a0Hz) left atria and spontaneously beating right atria of these D\n                    <jats:sub>1<\/jats:sub>\n                    -TG mice in vitro. The intrinsic heart beat in the right atria from D\n                    <jats:sub>1<\/jats:sub>\n                    -TG mice lowered when we reduced the temperature (24\u00a0\u00b0C, hypothermia) and elevated when we raised the temperature (42\u00a0\u00b0C, hyperthermia) in the organ baths. In addition, the efficacy of dopamine (0.001\u2013100\u00a0\u00b5M) to augment the force of contraction was diminished in the left and right D\n                    <jats:sub>1<\/jats:sub>\n                    -TG mouse atrial preparations under 24\u00a0\u00b0C and 42\u00a0\u00b0C compared to 37\u00a0\u00b0C in the organ baths. Likewise, the rise in force after dopamine was diminished at 24\u00a0\u00b0C and 42\u00a0\u00b0C compared to 37\u00a0\u00b0C in paced human atrial preparations (HAP) obtained from patients who underwent surgery. In conclusion, the inotropic effects of dopamine in D\n                    <jats:sub>1<\/jats:sub>\n                    -TG mice and in human atrial preparation via D\n                    <jats:sub>1<\/jats:sub>\n                    -dopamine receptors, but also the effects of dopamine in D\n                    <jats:sub>1<\/jats:sub>\n                    -TG mice on the heartbeat, change with ambient temperature.\n                  <\/jats:p>","DOI":"10.1007\/s00210-025-04313-6","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T06:24:30Z","timestamp":1748586270000},"page":"16209-16227","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Temperature alters the inotropic and chronotropic effect of D1-dopamine receptor stimulation in the mammalian atrium"],"prefix":"10.1007","volume":"398","author":[{"given":"Peter","family":"Grundig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh Hoai","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britt","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Gergs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"issue":"Suppl 1","key":"4313_CR1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s003950050200","volume":"93","author":"NR Alpert","year":"1998","unstructured":"Alpert NR, Leavitt BJ, Ittleman FP, Hasenfuss G, Pieske B, Mulieri LA (1998) A mechanistic analysis of the force-frequency relation in non-failing and progressively failing human myocardium. 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