{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T18:22:51Z","timestamp":1793816571010,"version":"4.6.1"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Haryana State Council for Science Innovation & Technology","award":["HSCSIT\/R&D\/2022\/2954"],"award-info":[{"award-number":["HSCSIT\/R&D\/2022\/2954"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s00210-025-04399-y","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T08:34:16Z","timestamp":1753346056000},"page":"1029-1047","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Gut microbiota metabolic axis dysfunction in estrogen deficient stressed rats"],"prefix":"10.1007","volume":"399","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7835-7371","authenticated-orcid":false,"given":"Rishabh","family":"Chaudhary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanpreet","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumeet","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanwaljit","family":"Chopra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2889-0004","authenticated-orcid":false,"given":"Seema","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"4399_CR1","doi-asserted-by":"crossref","unstructured":"Abbas MA, Al-Kabariti AY, Sutton C (2024) Comprehensive understanding of the role of GPER in estrogen receptor-alpha negative breast cancer. J Steroid Biochem Mol Biol 106523","DOI":"10.1016\/j.jsbmb.2024.106523"},{"key":"4399_CR2","doi-asserted-by":"crossref","unstructured":"Agrawal M, Bansal S, Chopra K (2021) Evaluation of the in vitro and in vivo antioxidant potentials of food grade Phycocyanin. J Food Sci Technol 1\u20139","DOI":"10.1007\/s13197-020-04922-4"},{"key":"4399_CR3","doi-asserted-by":"crossref","first-page":"150","DOI":"10.5005\/jp-journals-10006-2402","volume":"16","author":"P Alva","year":"2024","unstructured":"Alva P, Rai S, Naresh S, Anand P (2024) An Update on Gut Microbiome and Postmenopausal Health with Clinical Implications. J South Asian Federation Obstetrics Gynaecol 16:150\u2013155","journal-title":"J South Asian Federation Obstetrics Gynaecol"},{"key":"4399_CR4","doi-asserted-by":"crossref","unstructured":"Baghel K, Khan A, Kango N (2024) Role of Synbiotics (Prebiotics and Probiotics) as Dietary Supplements in Type 2 Diabetes Mellitus Induced Health Complications. J Diet Supplements 1\u201332","DOI":"10.1080\/19390211.2024.2340509"},{"key":"4399_CR5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ygcen.2014.06.013","volume":"206","author":"S Bansal","year":"2014","unstructured":"Bansal S, Chopra K (2014) Distinct role of estrogen receptor-alpha and beta on postmenopausal diabetes-induced vascular dysfunction. Gen Comp Endocrinol 206:51\u201359","journal-title":"Gen Comp Endocrinol"},{"key":"4399_CR6","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.mce.2017.07.017","volume":"460","author":"S Bansal","year":"2018","unstructured":"Bansal S, Chopra K (2018) Selective ER-\u03b1 agonist alleviates vascular endothelial dysfunction in ovariectomized type 2 diabetic rats. Mol Cell Endocrinol 460:152\u2013161","journal-title":"Mol Cell Endocrinol"},{"key":"4399_CR7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4103\/ijp.IJP_233_18","volume":"53","author":"S Bansal","year":"2021","unstructured":"Bansal S, Chopra K (2021) Construction of time-response curve for neuronal and vascular endothelial dysfunction in ovariectomized rats. Indian J Pharmacol 53:31","journal-title":"Indian J Pharmacol"},{"key":"4399_CR8","doi-asserted-by":"crossref","first-page":"774","DOI":"10.3390\/foods10040774","volume":"10","author":"AR Basson","year":"2021","unstructured":"Basson AR, Ahmed S, Almutairi R, Seo B, Cominelli F (2021) Regulation of intestinal inflammation by soybean and soy-derived compounds. Foods 10:774","journal-title":"Foods"},{"key":"4399_CR9","doi-asserted-by":"crossref","first-page":"930928","DOI":"10.3389\/fmicb.2022.930928","volume":"13","author":"R Bhatia","year":"2022","unstructured":"Bhatia R, Sharma S, Bhadada SK, Bishnoi M, Kondepudi KK (2022) Lactic acid bacterial supplementation ameliorated the lipopolysaccharide-induced gut inflammation and dysbiosis in mice. Front Microbiol 13:930928","journal-title":"Front Microbiol"},{"key":"4399_CR10","doi-asserted-by":"crossref","first-page":"pdb. prot073411","DOI":"10.1101\/pdb.prot073411","volume":"2014","author":"RD Cardiff","year":"2014","unstructured":"Cardiff RD, Miller CH, Munn RJ (2014) Manual hematoxylin and eosin staining of mouse tissue sections. Cold Spring Harbor Protocols 2014:pdb. prot073411","journal-title":"Cold Spring Harbor Protocols"},{"key":"4399_CR11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0378-5122(94)90005-1","volume":"20","author":"A Collins","year":"1994","unstructured":"Collins A, Landgren B-M (1994) Reproductive health, use of estrogen and experience of symptoms in perimenopausal women: a population-based study. Maturitas 20:101\u2013111","journal-title":"Maturitas"},{"key":"4399_CR12","doi-asserted-by":"crossref","first-page":"e13263","DOI":"10.14814\/phy2.13263","volume":"5","author":"FL Collins","year":"2017","unstructured":"Collins FL, Rios-Arce ND, Atkinson S, Bierhalter H, Schoenherr D, Bazil JN, McCabe LR, Parameswaran N (2017) Temporal and regional intestinal changes in permeability, tight junction, and cytokine gene expression following ovariectomy-induced estrogen deficiency. Physiol Rep 5:e13263","journal-title":"Physiol Rep"},{"key":"4399_CR13","doi-asserted-by":"crossref","first-page":"e982426","DOI":"10.4161\/21688370.2014.982426","volume":"3","author":"S Cornick","year":"2015","unstructured":"Cornick S, Tawiah A, Chadee K (2015) Roles and regulation of the mucus barrier in the gut. Tissue Barriers 3:e982426","journal-title":"Tissue Barriers"},{"key":"4399_CR14","doi-asserted-by":"crossref","first-page":"572490","DOI":"10.3389\/fendo.2020.572490","volume":"11","author":"S Della Torre","year":"2020","unstructured":"Della Torre S (2020) Non-alcoholic fatty liver disease as a canonical example of metabolic inflammatory-based liver disease showing a sex-specific prevalence: relevance of estrogen signaling. Front Endocrinol 11:572490","journal-title":"Front Endocrinol"},{"key":"4399_CR15","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/jam.13765","volume":"125","author":"J Dhaliwal","year":"2018","unstructured":"Dhaliwal J, Singh D, Singh S, Pinnaka AK, Boparai R, Bishnoi M, Kondepudi K, Chopra K (2018) Lactobacillus plantarum MTCC 9510 supplementation protects from chronic unpredictable and sleep deprivation-induced behaviour, biochemical and selected gut microbial aberrations in mice. J Appl Microbiol 125:257\u2013269","journal-title":"J Appl Microbiol"},{"key":"4399_CR16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/09513590.2020.1832068","volume":"37","author":"CCNd Fonseca","year":"2021","unstructured":"Fonseca CCNd, Cezar LC, Franco PC, Simoes RS, Sasso GRdS, Simoes MdJ, Florencio-Silva R (2021) Effects of soy isoflavones extract on the lipid profile and uterus in ovariectomized rats. Gynecol Endocrinol 37:177\u2013184","journal-title":"Gynecol Endocrinol"},{"key":"4399_CR17","doi-asserted-by":"crossref","first-page":"1946853","DOI":"10.1155\/2020\/1946853","volume":"2020","author":"X Fu","year":"2020","unstructured":"Fu X, Zheng Q, Zhang N, Ding M, Pan X, Wang W, Chen H (2020) CUMS promotes the development of premature ovarian insufficiency mediated by nerve growth factor and its receptor in rats. Biomed Res Int 2020:1946853","journal-title":"Biomed Res Int"},{"key":"4399_CR18","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.3390\/nu15163514","volume":"15","author":"P-X Huang","year":"2023","unstructured":"Huang P-X, Yeh C-L, Yang S-C, Shirakawa H, Chang C-L, Chen L-H, Chiu Y-S, Chiu W-C (2023) Rice Bran Supplementation Ameliorates Gut Dysbiosis and Muscle Atrophy in Ovariectomized Mice Fed with a High-Fat Diet. Nutrients 15:3514","journal-title":"Nutrients"},{"key":"4399_CR19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40168-018-0587-0","volume":"6","author":"K Kaliannan","year":"2018","unstructured":"Kaliannan K, Robertson RC, Murphy K, Stanton C, Kang C, Wang B, Hao L, Bhan AK, Kang JX (2018) Estrogen-mediated gut microbiome alterations influence sexual dimorphism in metabolic syndrome in mice. Microbiome 6:1\u201322","journal-title":"Microbiome"},{"key":"4399_CR20","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.steroids.2015.01.004","volume":"96","author":"SP Kaur","year":"2015","unstructured":"Kaur SP, Bansal S, Chopra K (2015) 17\u03b1-Estradiol: a candidate neuroserm and non-feminizing estrogen for postmenopausal neuronal complications. Steroids 96:7\u201315","journal-title":"Steroids"},{"key":"4399_CR21","doi-asserted-by":"crossref","first-page":"21397","DOI":"10.1038\/s41598-021-00601-2","volume":"11","author":"S Khanna","year":"2021","unstructured":"Khanna S, Bishnoi M, Kondepudi KK, Shukla G (2021) Synbiotic (Lactiplantibacillus pentosus GSSK2 and isomalto-oligosaccharides) supplementation modulates pathophysiology and gut dysbiosis in experimental metabolic syndrome. Sci Rep 11:21397","journal-title":"Sci Rep"},{"key":"4399_CR22","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s11894-010-0131-2","volume":"12","author":"YS Kim","year":"2010","unstructured":"Kim YS, Ho SB (2010) Intestinal goblet cells and mucins in health and disease: recent insights and progress. Curr Gastroenterol Rep 12:319\u2013330","journal-title":"Curr Gastroenterol Rep"},{"key":"4399_CR23","first-page":"1","volume":"20","author":"HR Kim","year":"2020","unstructured":"Kim HR, Lee Y-J, Kim T-W, Lim R-N, Hwang DY, Moffat JJ, Kim S, Seo J-W, Ka M (2020) Asparagus cochinchinensis extract ameliorates menopausal depression in ovariectomized rats under chronic unpredictable mild stress. BMC Complement Med Ther 20:1\u201315","journal-title":"BMC Complement Med Ther"},{"key":"4399_CR24","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.18632\/aging.203947","volume":"14","author":"JM Kim","year":"2022","unstructured":"Kim JM, Kim JH, Kim K, Shin S-C, Cheon Y-I, Kim HS, Lee J-C, Sung E-S, Lee M, Park G-C (2022) Tonsil mesenchymal stem cells-derived extracellular vesicles prevent submandibular gland dysfunction in ovariectomized rats. Aging (Albany NY) 14:2194","journal-title":"Aging (Albany NY)"},{"key":"4399_CR25","first-page":"591","volume":"62","author":"PC Konturek","year":"2011","unstructured":"Konturek PC, Brzozowski T, Konturek SJ (2011) Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options. J Physiol Pharmacol 62:591\u2013599","journal-title":"J Physiol Pharmacol"},{"key":"4399_CR26","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.3390\/nu11081726","volume":"11","author":"A Koshkina","year":"2019","unstructured":"Koshkina A, Dudnichenko T, Baranenko D, Fedotova J, Drago F (2019) Effects of vitamin D3 in long-term ovariectomized rats subjected to chronic unpredictable mild stress: BDNF, NT-3, and NT-4 implications. Nutrients 11:1726","journal-title":"Nutrients"},{"key":"4399_CR27","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00213-010-2094-2","volume":"214","author":"B Kumar","year":"2011","unstructured":"Kumar B, Kuhad A, Chopra K (2011) Neuropsychopharmacological effect of sesamol in unpredictable chronic mild stress model of depression: behavioral and biochemical evidences. Psychopharmacology 214:819\u2013828","journal-title":"Psychopharmacology"},{"key":"4399_CR28","doi-asserted-by":"crossref","first-page":"2300688","DOI":"10.1002\/mnfr.202300688","volume":"68","author":"N Kumari","year":"2024","unstructured":"Kumari N, Kumari R, Dua A, Singh M, Kumar R, Singh P, Duyar-Ayerdi S, Pradeep S, Ojesina AI, Kumar R (2024) From gut to hormones: unraveling the role of gut microbiota in (phyto) estrogen modulation in health and disease. Mol Nutr Food Res 68:2300688","journal-title":"Mol Nutr Food Res"},{"key":"4399_CR29","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.yhbeh.2010.07.014","volume":"58","author":"N Lagunas","year":"2010","unstructured":"Lagunas N, Calmarza-Font I, Diz-Chaves Y, Garcia-Segura LM (2010) Long-term ovariectomy enhances anxiety and depressive-like behaviors in mice submitted to chronic unpredictable stress. Horm Behav 58:786\u2013791","journal-title":"Horm Behav"},{"key":"4399_CR30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-020-02040-8","volume":"18","author":"H Li","year":"2021","unstructured":"Li H, Xiang Y, Zhu Z, Wang W, Jiang Z, Zhao M, Cheng S, Pan F, Liu D, Ho RC (2021) Rifaximin-mediated gut microbiota regulation modulates the function of microglia and protects against CUMS-induced depression-like behaviors in adolescent rat. J Neuroinflammation 18:1\u201318","journal-title":"J Neuroinflammation"},{"key":"4399_CR31","doi-asserted-by":"crossref","first-page":"1149185","DOI":"10.3389\/fphar.2023.1149185","volume":"14","author":"C Li","year":"2023","unstructured":"Li C, Su Z, Chen Z, Cao J, Liu X, Xu F (2023) Lactobacillus reuteri strain 8008 attenuated the aggravation of depressive-like behavior induced by CUMS in high-fat diet-fed mice through regulating the gut microbiota. Front Pharmacol 14:1149185","journal-title":"Front Pharmacol"},{"key":"4399_CR32","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.neulet.2016.02.040","volume":"618","author":"J Lu","year":"2016","unstructured":"Lu J, Shao R-H, Hu L, Tu Y, Guo J-Y (2016) Potential antiinflammatory effects of acupuncture in a chronic stress model of depression in rats. Neurosci Lett 618:31\u201338","journal-title":"Neurosci Lett"},{"key":"4399_CR33","first-page":"7902874","volume":"2019","author":"W-j Lv","year":"2019","unstructured":"Lv W-j, Wu X-l, Chen W-q, Li Y-f, Zhang G-f, Chao L-m, Zhou J-h, Guo A, Liu C, Guo S-n (2019) The gut microbiome modulates the changes in liver metabolism and in inflammatory processes in the brain of chronic unpredictable mild stress rats. Oxid Med Cell Longev 2019:7902874","journal-title":"Oxid Med Cell Longev"},{"key":"4399_CR34","doi-asserted-by":"crossref","first-page":"7154","DOI":"10.3390\/ijms23137154","volume":"23","author":"S Maffei","year":"2022","unstructured":"Maffei S, Forini F, Canale P, Nicolini G, Guiducci L (2022) Gut microbiota and sex hormones: crosstalking players in cardiometabolic and cardiovascular disease. Int J Mol Sci 23:7154","journal-title":"Int J Mol Sci"},{"key":"4399_CR35","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.3390\/nu16111629","volume":"16","author":"E Mazza","year":"2024","unstructured":"Mazza E, Troiano E, Ferro Y, Lisso F, Tosi M, Turco E, Pujia R, Montalcini T (2024) Obesity, Dietary Patterns, and Hormonal Balance Modulation: Gender-Specific Impacts. Nutrients 16:1629","journal-title":"Nutrients"},{"key":"4399_CR36","doi-asserted-by":"crossref","first-page":"5719291","DOI":"10.1155\/2016\/5719291","volume":"2016","author":"MdS Morrone","year":"2016","unstructured":"Morrone MdS, Schnorr CE, Behr GA, Gasparotto J, Bortolin RC, da Boit MK, Saldanha Henkin B, Rabello TK, Zanotto-Filho A, Gelain DP (2016) Curcumin supplementation decreases intestinal adiposity accumulation, serum cholesterol alterations, and oxidative stress in ovariectomized rats. Oxid Med Cell Longev 2016:5719291","journal-title":"Oxid Med Cell Longev"},{"key":"4399_CR37","doi-asserted-by":"crossref","unstructured":"Mulinari Turin de Oliveira N, Schiebel CS, Sauruk da Silva K, de Mello Braga LLV, Bach C, Maria-Ferreira D (2025) Efficacy of Dietary Supplementation in the Relief of Inflammatory Bowel Disease: A Systematic Review of Animal Studies. Nutrition Rev nuae224","DOI":"10.1093\/nutrit\/nuae224"},{"key":"4399_CR38","doi-asserted-by":"crossref","first-page":"5561","DOI":"10.3390\/ijms25105561","volume":"25","author":"G Olteanu","year":"2024","unstructured":"Olteanu G, Ciuc\u0103-Pan\u0103 M-A, Busnatu \u0218S, Lupuliasa D, Neac\u0219u SM, Mititelu M, Musuc AM, Ioni\u021b\u0103-M\u00eendrican C-B, Boroghin\u0103 SC (2024) Unraveling the microbiome-human body axis: a comprehensive examination of therapeutic strategies, interactions and implications. Int J Mol Sci 25:5561","journal-title":"Int J Mol Sci"},{"key":"4399_CR39","doi-asserted-by":"crossref","first-page":"5599265","DOI":"10.1155\/2021\/5599265","volume":"2021","author":"BA Oroian","year":"2021","unstructured":"Oroian BA, Ciobica A, Timofte D, Stefanescu C, Serban IL (2021) New metabolic, digestive, and oxidative stress-related manifestations associated with posttraumatic stress disorder. Oxid Med Cell Longev 2021:5599265","journal-title":"Oxid Med Cell Longev"},{"key":"4399_CR40","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.lfs.2008.03.021","volume":"82","author":"JA Park","year":"2008","unstructured":"Park JA, Ha SK, Kang TH, Oh MS, Cho MH, Lee SY, Park J-H, Kim SY (2008) Protective effect of apigenin on ovariectomy-induced bone loss in rats. Life Sci 82:1217\u20131223","journal-title":"Life Sci"},{"key":"4399_CR41","doi-asserted-by":"crossref","first-page":"5886","DOI":"10.1039\/C9FO00399A","volume":"10","author":"W Qu","year":"2019","unstructured":"Qu W, Liu S, Zhang W, Zhu H, Tao Q, Wang H, Yan H (2019) Impact of traditional Chinese medicine treatment on chronic unpredictable mild stress-induced depression-like behaviors: intestinal microbiota and gut microbiome function. Food Funct 10:5886\u20135897","journal-title":"Food Funct"},{"key":"4399_CR42","doi-asserted-by":"crossref","first-page":"837543","DOI":"10.3389\/fphar.2022.837543","volume":"13","author":"Y Qu","year":"2022","unstructured":"Qu Y, Su C, Zhao Q, Shi A, Zhao F, Tang L, Xu D, Xiang Z, Wang Y, Wang Y (2022) Gut microbiota-mediated elevated production of secondary bile acids in chronic unpredictable mild stress. Front Pharmacol 13:837543","journal-title":"Front Pharmacol"},{"key":"4399_CR43","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.lfs.2016.02.002","volume":"148","author":"V Rani","year":"2016","unstructured":"Rani V, Deep G, Singh RK, Palle K, Yadav UC (2016) Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies. Life Sci 148:183\u2013193","journal-title":"Life Sci"},{"key":"4399_CR44","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.cellsig.2012.01.008","volume":"24","author":"PD Ray","year":"2012","unstructured":"Ray PD, Huang B-W, Tsuji Y (2012) Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal 24:981\u2013990","journal-title":"Cell Signal"},{"key":"4399_CR45","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2174\/0115733998275953231129094057","volume":"20","author":"BS Rishabh","year":"2024","unstructured":"Rishabh BS, Goel A, Gupta S, Malik D, Bansal N (2024) Unravelling the crosstalk between estrogen deficiency and gut-biota dysbiosis in the development of diabetes mellitus. Curr Diabetes Rev 20:69\u201379","journal-title":"Curr Diabetes Rev"},{"key":"4399_CR46","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.maturitas.2021.06.012","volume":"151","author":"R Robeva","year":"2021","unstructured":"Robeva R, Mladenovi\u0107 D, Veskovi\u0107 M, Hrn\u010di\u0107 D, Bjeki\u0107-Macut J, Stanojlovi\u0107 O, Livadas S, Yildiz BO, Macut D (2021) The interplay between metabolic dysregulations and non-alcoholic fatty liver disease in women after menopause. Maturitas 151:22\u201330","journal-title":"Maturitas"},{"key":"4399_CR47","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1055\/s-0043-108250","volume":"49","author":"AL Russell","year":"2017","unstructured":"Russell AL, Grimes JM, Cruthirds DF, Westerfield J, Wooten L, Keil M, Weiser MJ, Landauer MR, Handa RJ, Wu TJ (2017) Dietary isoflavone-dependent and estradiol replacement effects on body weight in the ovariectomized (OVX) rat. Horm Metab Res 49:457\u2013465","journal-title":"Horm Metab Res"},{"key":"4399_CR48","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.ijbiomac.2017.08.100","volume":"106","author":"SM Sarma","year":"2018","unstructured":"Sarma SM, Singh DP, Singh P, Khare P, Mangal P, Singh S, Bijalwan V, Kaur J, Mantri S, Boparai RK (2018) Finger millet arabinoxylan protects mice from high-fat diet induced lipid derangements, inflammation, endotoxemia and gut bacterial dysbiosis. Int J Biol Macromol 106:994\u20131003","journal-title":"Int J Biol Macromol"},{"key":"4399_CR49","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.jmb.2018.01.010","volume":"430","author":"M Serino","year":"2018","unstructured":"Serino M (2018) Molecular paths linking metabolic diseases, gut microbiota dysbiosis and enterobacteria infections. J Mol Biol 430:581\u2013590","journal-title":"J Mol Biol"},{"key":"4399_CR50","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jare.2021.09.005","volume":"38","author":"S Shandilya","year":"2022","unstructured":"Shandilya S, Kumar S, Jha NK, Kesari KK, Ruokolainen J (2022) Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection. J Adv Res 38:223\u2013244","journal-title":"J Adv Res"},{"key":"4399_CR51","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.phrs.2017.06.015","volume":"123","author":"DP Singh","year":"2017","unstructured":"Singh DP, Singh J, Boparai RK, Zhu J, Mantri S, Khare P, Khardori R, Kondepudi KK, Chopra K, Bishnoi M (2017) Isomalto-oligosaccharides, a prebiotic, functionally augment green tea effects against high fat diet-induced metabolic alterations via preventing gut dysbacteriosis in mice. Pharmacol Res 123:103\u2013113","journal-title":"Pharmacol Res"},{"key":"4399_CR52","doi-asserted-by":"crossref","first-page":"4548","DOI":"10.1039\/C9FO00881K","volume":"11","author":"P Singh","year":"2020","unstructured":"Singh P, Bansal S, Kuhad A, Kumar A, Chopra K (2020a) Naringenin ameliorates diabetic neuropathic pain by modulation of oxidative-nitrosative stress, cytokines and MMP-9 levels. Food Funct 11:4548\u20134560","journal-title":"Food Funct"},{"key":"4399_CR53","doi-asserted-by":"crossref","first-page":"18597","DOI":"10.1038\/s41598-020-75702-5","volume":"10","author":"S Singh","year":"2020","unstructured":"Singh S, Bhatia R, Khare P, Sharma S, Rajarammohan S, Bishnoi M, Bhadada SK, Sharma SS, Kaur J, Kondepudi KK (2020b) Anti-inflammatory Bifidobacterium strains prevent dextran sodium sulfate induced colitis and associated gut microbial dysbiosis in mice. Sci Rep 10:18597","journal-title":"Sci Rep"},{"key":"4399_CR54","doi-asserted-by":"crossref","first-page":"AP366-AP366","DOI":"10.1161\/res.129.suppl_1.P366","volume":"129","author":"AE Solomon","year":"2021","unstructured":"Solomon AE, Hoyer-Kimura C, Kangath A, Duca F, Konhilas JP (2021) Abstract P366: The Impact Of Estrogen Signaling On Gut Epithelial Cells. Circulation Research 129:AP366\u2013AP366","journal-title":"Circulation Research"},{"key":"4399_CR55","doi-asserted-by":"crossref","first-page":"889923","DOI":"10.3389\/fendo.2022.889923","volume":"13","author":"BM Steiner","year":"2022","unstructured":"Steiner BM, Berry DC (2022) The regulation of adipose tissue health by estrogens. Front Endocrinol 13:889923","journal-title":"Front Endocrinol"},{"key":"4399_CR56","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/iub.1496","volume":"68","author":"Q Su","year":"2016","unstructured":"Su Q, Tao W, Wang H, Chen Y, Huang H, Chen G (2016) Umbelliferone attenuates unpredictable chronic mild stress induced-insulin resistance in rats. IUBMB Life 68:403\u2013409","journal-title":"IUBMB Life"},{"key":"4399_CR57","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1089\/rej.2015.1724","volume":"19","author":"Y Sun","year":"2016","unstructured":"Sun Y, Yu Q, Shen Q, Bai W, Kang J (2016) Black cohosh ameliorates metabolic disorders in female ovariectomized rats. Rejuvenation Res 19:204\u2013214","journal-title":"Rejuvenation Res"},{"key":"4399_CR58","doi-asserted-by":"crossref","first-page":"1328324","DOI":"10.3389\/fmicb.2024.1328324","volume":"15","author":"Y Sun","year":"2024","unstructured":"Sun Y, Wang X, Li L, Zhong C, Zhang Y, Yang X, Li M, Yang C (2024) The role of gut microbiota in intestinal disease: From an oxidative stress perspective. Front Microbiol 15:1328324","journal-title":"Front Microbiol"},{"key":"4399_CR59","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41398-020-01132-6","volume":"11","author":"T Teng","year":"2021","unstructured":"Teng T, Shively CA, Li X, Jiang X, Neigh GN, Yin B, Zhang Y, Fan L, Xiang Y, Wang M (2021) Chronic unpredictable mild stress produces depressive-like behavior, hypercortisolemia, and metabolic dysfunction in adolescent cynomolgus monkeys. Transl Psychiatry 11:9","journal-title":"Transl Psychiatry"},{"key":"4399_CR60","doi-asserted-by":"crossref","first-page":"1415216","DOI":"10.3389\/fendo.2024.1415216","volume":"15","author":"J Wang","year":"2024","unstructured":"Wang J, Su C, Qian M, Wang X, Chen C, Liu Y, Liu W, Xiang Z, Xu B (2024) Subchronic toxic effects of bisphenol A on the gut-liver-hormone axis in rats via intestinal flora and metabolism. Front Endocrinol 15:1415216","journal-title":"Front Endocrinol"},{"key":"4399_CR61","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.3389\/fphys.2019.01228","volume":"10","author":"L Wei","year":"2019","unstructured":"Wei L, Li Y, Tang W, Sun Q, Chen L, Wang X, Liu Q, Yu S, Yu S, Liu C (2019) Chronic unpredictable mild stress in rats induces colonic inflammation. Front Physiol 10:1228","journal-title":"Front Physiol"},{"key":"4399_CR62","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.3892\/mmr.2013.1670","volume":"8","author":"Q-Z Yin","year":"2013","unstructured":"Yin Q-Z, Lu H, Li L-M, Yie S-M, Hu X, Liu Z-B, Zheng X, Cao S, Yao Z-Y (2013) Impacts of You Gui Wan on the expression of estrogen receptors and angiogenic factors in OVX-rat vagina: a possible mechanism for the trophic effect of the formula on OVX-induced vaginal atrophy. Mol Med Rep 8:1329\u20131336","journal-title":"Mol Med Rep"},{"key":"4399_CR63","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.3390\/nu9101146","volume":"9","author":"Z Zhang","year":"2017","unstructured":"Zhang Z, Chen Y, Xiang L, Wang Z, Xiao GG, Hu J (2017) Effect of curcumin on the diversity of gut microbiota in ovariectomized rats. Nutrients 9:1146","journal-title":"Nutrients"},{"key":"4399_CR64","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.clim.2017.08.019","volume":"183","author":"Z Zhou","year":"2017","unstructured":"Zhou Z, Zhang L, Ding M, Luo Z, Yuan S, Bansal MB, Gilkeson G, Lang R, Jiang W (2017) Estrogen decreases tight junction protein ZO-1 expression in human primary gut tissues. Clin Immunol 183:174\u2013180","journal-title":"Clin Immunol"},{"key":"4399_CR65","doi-asserted-by":"crossref","first-page":"579995","DOI":"10.3389\/fpsyt.2020.579995","volume":"11","author":"X-D Zhou","year":"2020","unstructured":"Zhou X-D, Yang X-J, Zheng Y, Qin Z-S, Sha W, Chen G, Zhang Z-J (2020a) Jie-Yu Pill, a proprietary herbal medicine, ameliorates mood disorder-like behavior and cognitive impairment in estrogen-deprived mice exposed to chronic unpredictable mild stress: implication for a potential therapy of menopause syndrome. Front Psych 11:579995","journal-title":"Front Psych"},{"key":"4399_CR66","doi-asserted-by":"crossref","first-page":"112615","DOI":"10.1016\/j.jep.2020.112615","volume":"252","author":"X Zhou","year":"2020","unstructured":"Zhou X, Wang J, Lu Y, Chen C, Hu Y, Liu P, Dong X (2020b) Anti-depressive effects of Kai-Xin-San on lipid metabolism in depressed patients and CUMS rats using metabolomic analysis. J Ethnopharmacol 252:112615","journal-title":"J Ethnopharmacol"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04399-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-025-04399-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04399-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T22:04:25Z","timestamp":1771538665000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-025-04399-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,24]]},"references-count":66,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["4399"],"URL":"https:\/\/doi.org\/10.1007\/s00210-025-04399-y","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,24]]},"assertion":[{"value":"27 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"We declare that, this work is original, and has not been submitted elsewhere for publication.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Study was approved by the Institutional Animal Ethics Committee (IAEC) of M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana-133207 wide protocol number: MMCP-IAEC-152 dated 29.12.2022.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}