{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:16:21Z","timestamp":1790997381775,"version":"4.1.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s00210-025-04451-x","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T10:00:35Z","timestamp":1753696835000},"page":"1079-1090","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["RBM15\/YTHDF2-mediated m6A modification of HTR1D exacerbates hypoxia-induced dysfunction in trophoblast cells in preeclampsia"],"prefix":"10.1007","volume":"399","author":[{"given":"Bing","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suqin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"key":"4451_CR1","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/S0140-6736(20)32335-7","volume":"398","author":"LC Chappell","year":"2021","unstructured":"Chappell LC, Cluver CA, Kingdom J, Tong S (2021) Pre-Eclampsia. Lancet 398:341\u2013354","journal-title":"Lancet"},{"key":"4451_CR2","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41572-023-00417-6","volume":"9","author":"E Dimitriadis","year":"2023","unstructured":"Dimitriadis E, Rolnik DL, Zhou W et al (2023) Pre-Eclampsia Nat Rev Dis Primers 9:8","journal-title":"Pre-Eclampsia Nat Rev Dis Primers"},{"key":"4451_CR3","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.tins.2020.02.003","volume":"43","author":"SB Gumusoglu","year":"2020","unstructured":"Gumusoglu SB, Chilukuri ASS, Santillan DA, Santillan MK, Stevens HE (2020) Neurodevelopmental Outcomes of Prenatal Preeclampsia Exposure. Trends Neurosci 43:253\u2013268","journal-title":"Trends Neurosci"},{"key":"4451_CR4","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s11906-021-01155-4","volume":"23","author":"S Gumusoglu","year":"2021","unstructured":"Gumusoglu S, Scroggins S, Vignato J, Santillan D, Santillan M (2021) The Serotonin-Immune Axis in Preeclampsia. Curr Hypertens Rep 23:37","journal-title":"Curr Hypertens Rep"},{"key":"4451_CR5","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1080\/10641955.2016.1259627","volume":"36","author":"HA Korkes","year":"2017","unstructured":"Korkes HA, De Oliveira L, Sass N et al (2017) Relationship between hypoxia and downstream pathogenic pathways in preeclampsia. Hypertens Pregnancy 36:145\u2013150","journal-title":"Hypertens Pregnancy"},{"key":"4451_CR6","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1186\/s13062-024-00572-0","volume":"19","author":"L Li","year":"2024","unstructured":"Li L, He H, Zheng Z, Zhao X (2024) MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15\/TRIM72\/ADAM9 axis. Biol Direct 19:133","journal-title":"Biol Direct"},{"key":"4451_CR7","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1186\/s12906-017-2006-7","volume":"17","author":"J Pan","year":"2017","unstructured":"Pan J, Xu Y, Song H et al (2017) Extracts of Zuo Jin Wan, a traditional Chinese medicine, phenocopies 5-HTR1D antagonist in attenuating Wnt\/\u03b2-catenin signaling in colorectal cancer cells. BMC Complement Altern Med 17:506","journal-title":"BMC Complement Altern Med"},{"key":"4451_CR8","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/nature19342","volume":"537","author":"DP Patil","year":"2016","unstructured":"Patil DP, Chen CK, Pickering BF et al (2016) m(6)A RNA methylation promotes XIST-mediated transcriptional repression. Nat 537:369\u2013373","journal-title":"Nat"},{"key":"4451_CR9","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1530\/REP-20-0483","volume":"161","author":"BE Perlman","year":"2021","unstructured":"Perlman BE, Merriam AA, Lemenze A et al (2021) Implications for preeclampsia: hypoxia-induced Notch promotes trophoblast migration. Reprod 161:681\u2013696","journal-title":"Reprod"},{"key":"4451_CR10","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1161\/CIRCRESAHA.118.313276","volume":"124","author":"S Rana","year":"2019","unstructured":"Rana S, Lemoine E, Granger JP, Karumanchi SA (2019) Preeclampsia: Pathophysiology, Challenges, and Perspectives. Circ Res 124:1094\u20131112","journal-title":"Circ Res"},{"key":"4451_CR11","doi-asserted-by":"publisher","first-page":"S1019","DOI":"10.1016\/j.ajog.2020.10.022","volume":"226","author":"S Rana","year":"2022","unstructured":"Rana S, Burke SD, Karumanchi SA (2022) Imbalances in circulating angiogenic factors in the pathophysiology of preeclampsia and related disorders. Am J Obstet Gynecol 226:S1019-s1034","journal-title":"Am J Obstet Gynecol"},{"key":"4451_CR12","doi-asserted-by":"publisher","first-page":"102480","DOI":"10.1016\/j.bpobgyn.2024.102480","volume":"94","author":"JM Roberts","year":"2024","unstructured":"Roberts JM (2024) Preeclampsia epidemiology(ies) and pathophysiology(ies). Best Pract Res Clin Obstet Gynaecol 94:102480","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"4451_CR13","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.ecl.2024.05.012","volume":"53","author":"EA Rosenberg","year":"2024","unstructured":"Rosenberg EA, Seely EW (2024) Update on Preeclampsia and Hypertensive Disorders of Pregnancy. Endocrinol Metab Clin North Am 53:377\u2013389","journal-title":"Endocrinol Metab Clin North Am"},{"key":"4451_CR14","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1085\/jgp.201812066","volume":"151","author":"G Rudnick","year":"2019","unstructured":"Rudnick G, Sandtner W (2019) Serotonin transport in the 21st century. J Gen Physiol 151:1248\u20131264","journal-title":"J Gen Physiol"},{"key":"4451_CR15","doi-asserted-by":"publisher","first-page":"e323","DOI":"10.1016\/S2214-109X(14)70227-X","volume":"2","author":"L Say","year":"2014","unstructured":"Say L, Chou D, Gemmill A et al (2014) Global causes of maternal death: a WHO systematic analysis. Lancet Glob Health 2:e323-333","journal-title":"Lancet Glob Health"},{"key":"4451_CR16","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1002\/uog.27510","volume":"63","author":"J Torres-Torres","year":"2024","unstructured":"Torres-Torres J, Villafan-Bernal JR, Martinez-Portilla RJ et al (2024a) Performance of machine-learning approach for prediction of pre-eclampsia in a middle-income country. Ultrasound Obstet Gynecol 63:350\u2013357","journal-title":"Ultrasound Obstet Gynecol"},{"key":"4451_CR17","doi-asserted-by":"crossref","unstructured":"Torres-Torres J, Espino YSS, Martinez-Portilla R, et al (2024b) A narrative review on the pathophysiology of preeclampsia. Int J Mol Sci 25:7569","DOI":"10.3390\/ijms25147569"},{"key":"4451_CR18","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1002\/jor.22623","volume":"32","author":"S Tsuchida","year":"2014","unstructured":"Tsuchida S, Arai Y, Takahashi KA et al (2014) HIF-1\u03b1-induced HSP70 regulates anabolic responses in articular chondrocytes under hypoxic conditions. J Orthop Res 32:975\u2013980","journal-title":"J Orthop Res"},{"key":"4451_CR19","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1016\/j.cell.2015.05.014","volume":"161","author":"X Wang","year":"2015","unstructured":"Wang X, Zhao BS, Roundtree IA et al (2015) N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency. Cell 161:1388\u20131399","journal-title":"Cell"},{"key":"4451_CR20","doi-asserted-by":"publisher","first-page":"3777","DOI":"10.7150\/ijbs.70546","volume":"18","author":"W Wu","year":"2022","unstructured":"Wu W, Li Q, Zhu Z et al (2022) HTR1D functions as a key target of HOXA10-AS\/miR-340-3p axis to promote the malignant outcome of pancreatic cancer via PI3K-AKT signaling pathway. Int J Biol Sci 18:3777\u20133794","journal-title":"Int J Biol Sci"},{"key":"4451_CR21","doi-asserted-by":"publisher","first-page":"e30702","DOI":"10.1016\/j.heliyon.2024.e30702","volume":"10","author":"G You","year":"2024","unstructured":"You G, Li Z, Li L, Xu C (2024) Overexpression of RBM15 modulated the effect of trophoblast cells by promoting the binding ability between YTHDF2 and the CD82 3\u2019UTR to decrease the expression of CD82. Heliyon 10:e30702","journal-title":"Heliyon"},{"key":"4451_CR22","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1186\/s12885-025-13575-5","volume":"25","author":"Y Zhang","year":"2025","unstructured":"Zhang Y, Zhang Y, Zhou S et al (2025) HTR1D regulates the PI3K\/Akt signaling pathway to impact hepatocellular carcinoma development and resistance to sorafenib. BMC Cancer 25:185","journal-title":"BMC Cancer"},{"key":"4451_CR23","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/s41420-023-01321-4","volume":"9","author":"Y Zhu","year":"2023","unstructured":"Zhu Y, Li J, Yang H et al (2023) The potential role of m6A reader YTHDF1 as diagnostic biomarker and the signaling pathways in tumorigenesis and metastasis in pan-cancer. Cell Death Discov 9:34","journal-title":"Cell Death Discov"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04451-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-025-04451-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04451-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T22:06:41Z","timestamp":1771538801000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-025-04451-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,28]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["4451"],"URL":"https:\/\/doi.org\/10.1007\/s00210-025-04451-x","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,28]]},"assertion":[{"value":"17 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The present study was approved by the ethical review committee of Yantaishan Hospital. Written informed consent was obtained from all enrolled patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Patients agree to participate in this work.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}