{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:25:45Z","timestamp":1790807145308,"version":"4.1.0"},"reference-count":119,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s00210-025-04513-0","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T09:18:55Z","timestamp":1754990335000},"page":"63-87","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Protective effects of taurine against chemical and natural compound-induced toxicity: mechanistic insights and therapeutic potential"],"prefix":"10.1007","volume":"399","author":[{"given":"Majid","family":"Keshavarzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibi Marjan","family":"Razavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Naraki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3483-851X","authenticated-orcid":false,"given":"Hossein","family":"Hosseinzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"4513_CR1","doi-asserted-by":"publisher","first-page":"117782","DOI":"10.1016\/j.lfs.2020.117782","volume":"254","author":"YM Abd-Elhakim","year":"2020","unstructured":"Abd-Elhakim YM, Ghoneim MH, Ebraheim LL, Imam TS (2020a) Taurine and hesperidin rescues carbon tetrachloride-triggered testicular and kidney damage in rats via modulating oxidative stress and inflammation. Life Sci 254:117782","journal-title":"Life Sci"},{"issue":"12","key":"4513_CR2","doi-asserted-by":"publisher","first-page":"13180","DOI":"10.1007\/s11356-020-07895-1","volume":"27","author":"YM Abd-Elhakim","year":"2020","unstructured":"Abd-Elhakim YM, Ghoneim MH, Khairy MH, Eissa SA (2020b) Single or combined protective and therapeutic impact of taurine and hesperidin on carbon tetrachloride-induced acute hepatic injury in rat. Environ Sci Pollut Res Int 27(12):13180\u201313193. https:\/\/doi.org\/10.1007\/s11356-020-07895-1","journal-title":"Environ Sci Pollut Res Int"},{"issue":"2","key":"4513_CR3","first-page":"149","volume":"39","author":"AN Abuirmeileh","year":"2021","unstructured":"Abuirmeileh AN, Abuhamdah SM, Ashraf A, Alzoubi KH (2021) Protective effect of caffeine and\/or taurine on the 6-hydroxydopamine-induced rat model of Parkinson\u2019s disease: behavioral and neurochemical evidence. Restor Neurol Neurosci 39(2):149\u2013157","journal-title":"Restor Neurol Neurosci"},{"key":"4513_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cbi.2016.11.011","volume":"261","author":"IA Adedara","year":"2017","unstructured":"Adedara IA, Abolaji AO, Idris UF et al (2017a) Neuroprotective influence of taurine on fluoride-induced biochemical and behavioral deficits in rats. Chemico-Bioll Int 261:1\u201310. https:\/\/doi.org\/10.1016\/j.cbi.2016.11.011","journal-title":"Chemico-Bioll Int"},{"key":"4513_CR5","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1007\/s12011-016-0784-2","volume":"175","author":"IA Adedara","year":"2017","unstructured":"Adedara IA, Ojuade TJD, Olabiyi BF et al (2017b) Taurine ameliorates renal oxidative damage and thyroid dysfunction in rats chronically exposed to fluoride. Biol Trace Elem Res 175:388\u2013395","journal-title":"Biol Trace Elem Res"},{"issue":"9","key":"4513_CR6","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1139\/cjpp-2016-0641","volume":"95","author":"IA Adedara","year":"2017","unstructured":"Adedara IA, Olabiyi BF, Ojuade TD, Idris UF, Onibiyo EM, Farombi EO (2017c) Taurine reverses sodium fluoride-mediated increase in inflammation, caspase-3 activity, and oxidative damage along the brain\u2013pituitary\u2013gonadal axis in male rats. Canadian J Physiol Pharmacol 95(9):1019\u20131029","journal-title":"Canadian J Physiol Pharmacol"},{"issue":"3","key":"4513_CR7","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/tox.22045","volume":"31","author":"MK Ahmad","year":"2016","unstructured":"Ahmad MK, Mahmood R (2016) Protective effect of taurine against potassium bromate-induced hemoglobin oxidation, oxidative stress, and impairment of antioxidant defense system in blood. Environ Toxicol 31(3):304\u2013313. https:\/\/doi.org\/10.1002\/tox.22045","journal-title":"Environ Toxicol"},{"issue":"5","key":"4513_CR8","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1007\/s00726-013-1563-4","volume":"45","author":"MK Ahmad","year":"2013","unstructured":"Ahmad MK, Khan AA, Mahmood R (2013) Taurine ameliorates potassium bromate-induced kidney damage in rats. Amino Acids 45(5):1109\u20131121. https:\/\/doi.org\/10.1007\/s00726-013-1563-4","journal-title":"Amino Acids"},{"issue":"3","key":"4513_CR9","doi-asserted-by":"publisher","first-page":"e0119137","DOI":"10.1371\/journal.pone.0119137","volume":"10","author":"MK Ahmad","year":"2015","unstructured":"Ahmad MK, Khan AA, Ali SN, Mahmood R (2015) Chemoprotective effect of taurine on potassium bromate-induced DNA damage, DNA-protein cross-linking and oxidative stress in rat intestine. PLoS ONE 10(3):e0119137","journal-title":"PLoS ONE"},{"key":"4513_CR10","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.brainres.2015.06.041","volume":"1622","author":"FK Alkholifi","year":"2015","unstructured":"Alkholifi FK, Albers DS (2015) Attenuation of rotenone toxicity in SY5Y cells by taurine and N-acetyl cysteine alone or in combination. Brain Res 1622:409\u2013413. https:\/\/doi.org\/10.1016\/j.brainres.2015.06.041","journal-title":"Brain Res"},{"issue":"12","key":"4513_CR11","doi-asserted-by":"publisher","first-page":"12302","DOI":"10.1007\/s11356-019-04578-4","volume":"26","author":"FG Apaydin","year":"2019","unstructured":"Apaydin FG, Aslanturk A, Uzunhisarcikli M, Bas H, Kalender S, Kalender Y (2019) Histopathological and biochemical studies on the effect of curcumin and taurine against bisphenol A toxicity in male rats. Environ Sci Pollut Res Int 26(12):12302\u201312310. https:\/\/doi.org\/10.1007\/s11356-019-04578-4","journal-title":"Environ Sci Pollut Res Int"},{"issue":"19","key":"4513_CR12","doi-asserted-by":"publisher","first-page":"23994","DOI":"10.1007\/s11356-020-08716-1","volume":"27","author":"A Aslanturk","year":"2020","unstructured":"Aslanturk A, Uzunhisarcikli M (2020) Protective potential of curcumin or taurine on nephrotoxicity caused by bisphenol A. Environ Sci Pollut Res Int 27(19):23994\u201324003. https:\/\/doi.org\/10.1007\/s11356-020-08716-1","journal-title":"Environ Sci Pollut Res Int"},{"issue":"2","key":"4513_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/mmr.2021.12242","volume":"24","author":"S Baliou","year":"2021","unstructured":"Baliou S, Adamaki M, Ioannou P et al (2021) Protective role of taurine against oxidative stress. Mol Med Rep 24(2):1\u201319","journal-title":"Mol Med Rep"},{"issue":"5","key":"4513_CR14","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.phrs.2009.05.006","volume":"60","author":"TM Bhavsar","year":"2009","unstructured":"Bhavsar TM, Cantor JO, Patel SN, Lau-Cam CA (2009) Attenuating effect of taurine on lipopolysaccharide-induced acute lung injury in hamsters. Pharmacol Res 60(5):418\u2013428. https:\/\/doi.org\/10.1016\/j.phrs.2009.05.006","journal-title":"Pharmacol Res"},{"issue":"1","key":"4513_CR15","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.toxlet.2014.11.009","volume":"232","author":"W Cao","year":"2015","unstructured":"Cao W, Zhou Y, Li Y et al (2015) iTRAQ-based proteomic analysis of combination therapy with taurine, epigallocatechin gallate, and genistein on carbon tetrachloride-induced liver fibrosis in rats. Toxicol Lett 232(1):233\u2013245","journal-title":"Toxicol Lett"},{"issue":"5","key":"4513_CR16","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1002\/hep.22811","volume":"49","author":"X Chen","year":"2009","unstructured":"Chen X, Sebastian BM, Tang H et al (2009) Taurine supplementation prevents ethanol-induced decrease in serum adiponectin and reduces hepatic steatosis in rats. Hepatol (Baltimore, Md) 49(5):1554\u20131562. https:\/\/doi.org\/10.1002\/hep.22811","journal-title":"Hepatol (Baltimore, Md)"},{"key":"4513_CR17","doi-asserted-by":"crossref","unstructured":"Cheong SH, Lee SH, Jeon YJ, Lee DS (2017) Mussel (Mytilus coruscus) water extract containing taurine prevents LPS-induced inflammatory responses in zebrafish model. In: Taurine 10. Springer, Dordrecht, pp 931\u2013942","DOI":"10.1007\/978-94-024-1079-2_74"},{"key":"4513_CR18","doi-asserted-by":"publisher","unstructured":"Chiang ST, Yeh SM, Chen YC, Lin SL, Tseng JK (2014) Investigation of the protective effects of taurine against alloxan-induced diabetic retinal changes via electroretinogram and retinal histology with New Zealand white rabbits. Int J Endocrinol 631549. https:\/\/doi.org\/10.1155\/2014\/631549","DOI":"10.1155\/2014\/631549"},{"issue":"4","key":"4513_CR19","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1007\/s00726-012-1225-y","volume":"43","author":"J Das","year":"2012","unstructured":"Das J, Sil PC (2012) Taurine ameliorates alloxan-induced diabetic renal injury, oxidative stress-related signaling pathways and apoptosis in rats. Amino Acids 43(4):1509\u20131523. https:\/\/doi.org\/10.1007\/s00726-012-1225-y","journal-title":"Amino Acids"},{"issue":"3","key":"4513_CR20","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.pathophys.2008.06.002","volume":"15","author":"J Das","year":"2008","unstructured":"Das J, Ghosh J, Manna P, Sil PC (2008) Taurine provides antioxidant defense against NaF-induced cytotoxicity in murine hepatocytes. Pathophysiol 15(3):181\u2013190","journal-title":"Pathophysiol"},{"issue":"2","key":"4513_CR21","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.taap.2011.11.009","volume":"258","author":"J Das","year":"2012","unstructured":"Das J, Vasan V, Sil PC (2012) Taurine exerts hypoglycemic effect in alloxan-induced diabetic rats, improves insulin-mediated glucose transport signaling pathway in heart and ameliorates cardiac oxidative stress and apoptosis. Toxicol Appl Pharmacol 258(2):296\u2013308","journal-title":"Toxicol Appl Pharmacol"},{"issue":"3","key":"4513_CR22","doi-asserted-by":"publisher","first-page":"350","DOI":"10.4103\/0970-9290.57379","volume":"20","author":"V Dhar","year":"2009","unstructured":"Dhar V, Bhatnagar M (2009) Physiology and toxicity of fluoride. Indian J Dent Res: Official Publication of Indian Society for Dental Research 20(3):350\u2013355. https:\/\/doi.org\/10.4103\/0970-9290.57379","journal-title":"Indian J Dent Res: Official Publication of Indian Society for Dental Research"},{"issue":"4","key":"4513_CR23","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s007260200025","volume":"22","author":"S Dincer","year":"2002","unstructured":"Dincer S, Ozenirler S, Oz E, Akyol G, Ozogul C (2002) The protective effect of taurine pretreatment on carbon tetrachloride-induced hepatic damage - a light and electron microscopic study. Amino Acids 22(4):417\u2013426. https:\/\/doi.org\/10.1007\/s007260200025","journal-title":"Amino Acids"},{"issue":"2","key":"4513_CR24","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1006\/jsre.2000.6005","volume":"95","author":"BM Egan","year":"2001","unstructured":"Egan BM, Chen G, Kelly CJ, Bouchier-Hayes DJ (2001) Taurine attenuates LPS-induced rolling and adhesion in rat microcirculation. J Surg Res 95(2):85\u201391. https:\/\/doi.org\/10.1006\/jsre.2000.6005","journal-title":"J Surg Res"},{"key":"4513_CR25","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s00726-004-0105-5","volume":"27","author":"F Erman","year":"2004","unstructured":"Erman F, Balkan J, Cevikba\u015f U, Kocak-Toker N, Uysal M (2004) Betaine or taurine administration prevents fibrosis and lipid peroxidation induced by rat liver by ethanol plus carbon tetrachloride intoxication. Amino Acids 27:199\u2013205","journal-title":"Amino Acids"},{"issue":"5","key":"4513_CR26","doi-asserted-by":"publisher","first-page":"677","DOI":"10.2131\/jts.41.677","volume":"41","author":"C Fujino","year":"2016","unstructured":"Fujino C, Tamura Y, Tange S et al (2016) Metabolism of methiocarb and carbaryl by rat and human livers and plasma, and effect on their PXR, CAR and PPAR\u03b1 activities. J Toxicol Sci 41(5):677\u2013691. https:\/\/doi.org\/10.2131\/jts.41.677","journal-title":"J Toxicol Sci"},{"key":"4513_CR27","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1475-2891-14-6","volume":"14","author":"P Ganguly","year":"2015","unstructured":"Ganguly P, Alam SF (2015) Role of homocysteine in the development of cardiovascular disease. Nutr J 14:6. https:\/\/doi.org\/10.1186\/1475-2891-14-6","journal-title":"Nutr J"},{"issue":"3","key":"4513_CR28","first-page":"34","volume":"71","author":"L Gavrovskaia","year":"2008","unstructured":"Gavrovskaia L, Ryzhova O, Safonova A, IIa A, Sapronov N (2008) Effect of taurine and thioctacide on carbohydrate metabolism and the antioxydant system in rats with experimental diabetes. Eksp Klin Farmakol 71(3):34\u201335","journal-title":"Eksp Klin Farmakol"},{"key":"4513_CR29","doi-asserted-by":"crossref","unstructured":"Gordon RE, Heller RF, Heller RF (1992) Taurine protection of lungs in hamster models of oxidant injury: a morphologic time study of paraquat and bleomycin treatment. In: Taurine: nutritional value and mechanisms of action. Springer, Boston, pp 319\u2013328","DOI":"10.1007\/978-1-4615-3436-5_38"},{"issue":"4","key":"4513_CR30","doi-asserted-by":"publisher","first-page":"305","DOI":"10.3109\/15376516.2012.657259","volume":"22","author":"Z Haojun","year":"2012","unstructured":"Haojun Z, Yaoling W, Ke Z, Jin L, Junling W (2012) Effects of NaF on the expression of intracellular Ca2+ fluxes and apoptosis and the antagonism of taurine in murine neuron. Toxicol Mech Methods 22(4):305\u2013308","journal-title":"Toxicol Mech Methods"},{"issue":"2","key":"4513_CR31","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/0091-3057(88)90368-1","volume":"31","author":"S Hashimoto-Kitsukawa","year":"1988","unstructured":"Hashimoto-Kitsukawa S, Okuyama S, Aihara H (1988) Enhancing effect of taurine in the rat caudate spindle. II: effect of bilateral 6-hydroxydopamine lesions of the nigro-striatal dopamine system. Pharmacol Biochem Behav 31(2):417\u2013423","journal-title":"Pharmacol Biochem Behav"},{"issue":"2","key":"4513_CR32","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/s0361-9230(01)00507-x","volume":"55","author":"J Hayes","year":"2001","unstructured":"Hayes J, Tipton KF, Bianchi L, Corte LD (2001) Complexities in the neurotoxic actions of 6-hydroxydopamine in relation to the cytoprotective properties of taurine. Brain Res Bull 55(2):239\u2013245. https:\/\/doi.org\/10.1016\/s0361-9230(01)00507-x","journal-title":"Brain Res Bull"},{"key":"4513_CR33","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.exer.2012.08.001","volume":"103","author":"YW Hsu","year":"2012","unstructured":"Hsu YW, Yeh SM, Chen YY, Chen YC, Lin SL, Tseng JK (2012) Protective effects of taurine against alloxan-induced diabetic cataracts and refraction changes in New Zealand white rabbits. Exp Eye Res 103:71\u201377. https:\/\/doi.org\/10.1016\/j.exer.2012.08.001","journal-title":"Exp Eye Res"},{"issue":"1","key":"4513_CR34","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1152\/physrev.1992.72.1.101","volume":"72","author":"R Huxtable","year":"1992","unstructured":"Huxtable R (1992) Physiological actions of taurine. Physiol Rev 72(1):101\u2013163","journal-title":"Physiol Rev"},{"key":"4513_CR35","unstructured":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (1991) Halogenated acetonitriles. In: Chlorinated drinking-water; chlorination by-products; some other halogenated compounds; cobalt and cobalt compounds, vol 52. International Agency for Research on Cancer, Lyon, pp 230\u2013257"},{"issue":"6","key":"4513_CR36","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.medici.2018.02.001","volume":"53","author":"OM Ighodaro","year":"2017","unstructured":"Ighodaro OM, Adeosun AM, Akinloye OA (2017) Alloxan-induced diabetes, a common model for evaluating the glycemic-control potential of therapeutic compounds and plants extracts in experimental studies. Medicina (Kaunas) 53(6):365\u2013374. https:\/\/doi.org\/10.1016\/j.medici.2018.02.001","journal-title":"Medicina (Kaunas)"},{"key":"4513_CR37","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.biopha.2017.09.141","volume":"96","author":"S Ince","year":"2017","unstructured":"Ince S, Arslan-Acaroz D, Demirel HH et al (2017) Taurine alleviates malathion induced lipid peroxidation, oxidative stress, and proinflammatory cytokine gene expressions in rats. Biomed Pharmacother 96:263\u2013268. https:\/\/doi.org\/10.1016\/j.biopha.2017.09.141","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"4513_CR38","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S0021-5198(19)42475-X","volume":"50","author":"K Izumi","year":"1989","unstructured":"Izumi K, Nagata R, Motoya T et al (1989) Preventive effect of taurine against acute paraquat intoxication in beagles. Japan J Pharmacol 50(2):229\u2013233","journal-title":"Japan J Pharmacol"},{"issue":"1","key":"4513_CR39","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3164\/jcbn.08-262","volume":"45","author":"JS Jang","year":"2009","unstructured":"Jang JS, Piao S, Cha Y-N, Kim C (2009) Taurine chloramine activates Nrf2, increases HO-1 expression and protects cells from death caused by hydrogen peroxide. J Clin Biochem Nutr 45(1):37\u201343","journal-title":"J Clin Biochem Nutr"},{"issue":"6","key":"4513_CR40","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.pupt.2009.07.004","volume":"22","author":"SH Jeon","year":"2009","unstructured":"Jeon SH, Lee MY, Rahman MM et al (2009) The antioxidant, taurine reduced lipopolysaccharide (LPS)-induced generation of ROS, and activation of MAPKs and Bax in cultured pneumocytes. Pul Pharmacol Ther 22(6):562\u2013566. https:\/\/doi.org\/10.1016\/j.pupt.2009.07.004","journal-title":"Pul Pharmacol Ther"},{"issue":"1\u20132","key":"4513_CR41","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/bf01345280","volume":"15","author":"MD Kerai","year":"1998","unstructured":"Kerai MD, Waterfield CJ, Kenyon SH, Asker DS, Timbrell JA (1998) Taurine: protective properties against ethanol-induced hepatic steatosis and lipid peroxidation during chronic ethanol consumption in rats. Amino Acids 15(1\u20132):53\u201376. https:\/\/doi.org\/10.1007\/bf01345280","journal-title":"Amino Acids"},{"key":"4513_CR42","doi-asserted-by":"crossref","unstructured":"Keshavarzi, M., Naraki, K., Razavi, B. M., & Hosseinzadeh, H (2025) A narrative review and new insights into the protective effects of taurine against drug side effects. Naunyn-Schmiedeberg's Arch Pharmacol 398(1):203\u2013230","DOI":"10.1007\/s00210-024-03331-0"},{"key":"4513_CR43","doi-asserted-by":"crossref","unstructured":"Kim YS, Kim EK, Hwang JW, Kim JS, Shin WB, Dong X et al (2017) Neuroprotective effect of taurine-rich cuttlefish (Sepia officinalis) extract against hydrogen peroxide-induced oxidative stress in SH-SY5Y cells. In: Taurine 10. Springer, Dordrecht, pp 243\u2013254","DOI":"10.1007\/978-94-024-1079-2_22"},{"issue":"4","key":"4513_CR44","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/s0278-6915(01)00102-8","volume":"40","author":"SK Kim","year":"2002","unstructured":"Kim SK, Kim YC (2002) Attenuation of bacterial lipopolysaccharide-induced hepatotoxicity by betaine or taurine in rats. Food Chem Toxicol\u202f: an International Journal Published for the British Industrial Biological Research Association 40(4):545\u2013549. https:\/\/doi.org\/10.1016\/s0278-6915(01)00102-8","journal-title":"Food Chem Toxicol : an International Journal Published for the British Industrial Biological Research Association"},{"key":"4513_CR45","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.yrtph.2017.08.022","volume":"90","author":"I Kimber","year":"2017","unstructured":"Kimber I (2017) Bisphenol A and immunotoxic potential: a commentary. Reg Toxicol Pharmacol: RTP 90:358\u2013363. https:\/\/doi.org\/10.1016\/j.yrtph.2017.08.022","journal-title":"Reg Toxicol Pharmacol: RTP"},{"key":"4513_CR46","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1289\/ehp.9087309","volume":"87","author":"Y Kurokawa","year":"1990","unstructured":"Kurokawa Y, Maekawa A, Takahashi M, Hayashi Y (1990) Toxicity and carcinogenicity of potassium bromate\u2013a new renal carcinogen. Environ Health Perspect 87:309\u2013335. https:\/\/doi.org\/10.1289\/ehp.9087309","journal-title":"Environ Health Perspect"},{"issue":"1","key":"4513_CR47","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1111\/apha.12365","volume":"213","author":"I Lambert","year":"2015","unstructured":"Lambert I, Kristensen D, Holm J, Mortensen O (2015) Physiological role of taurine\u2013from organism to organelle. Act Physiol 213(1):191\u2013212","journal-title":"Act Physiol"},{"issue":"Pt 2","key":"4513_CR48","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1007\/978-94-024-1079-2_70","volume":"975","author":"NY Lee","year":"2017","unstructured":"Lee NY, Kang YS (2017) Taurine protects glutamate neurotoxicity in motor neuron cells. Adv Exp Med Biol 975(Pt 2):887\u2013895. https:\/\/doi.org\/10.1007\/978-94-024-1079-2_70","journal-title":"Adv Exp Med Biol"},{"issue":"Pt 1","key":"4513_CR49","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/978-94-024-1079-2_12","volume":"975","author":"DS Lee","year":"2017","unstructured":"Lee DS, Kwon KH, Cheong SH (2017) Taurine chloramine suppresses LPS-induced neuroinflammatory responses through Nrf2-mediated heme oxygenase-1 expression in mouse BV2 microglial cells. Adv Exp Med Biol 975(Pt 1):131\u2013143. https:\/\/doi.org\/10.1007\/978-94-024-1079-2_12","journal-title":"Adv Exp Med Biol"},{"issue":"5","key":"4513_CR50","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1002\/jnr.21926","volume":"87","author":"R Leon","year":"2009","unstructured":"Leon R, Wu H, Jin Y et al (2009) Protective function of taurine in glutamate-induced apoptosis in cultured neurons. J Neurosci Res 87(5):1185\u20131194. https:\/\/doi.org\/10.1002\/jnr.21926","journal-title":"J Neurosci Res"},{"key":"4513_CR51","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/978-1-4614-6093-0_22","volume":"776","author":"Y Li","year":"2013","unstructured":"Li Y, Piao F, Liu X (2013) Protective effect of taurine on triorthocresyl phosphate (TOCP)-induced cytotoxicity in C6 glioma cells. Adv Exp Med Biol 776:231\u2013240. https:\/\/doi.org\/10.1007\/978-1-4614-6093-0_22","journal-title":"Adv Exp Med Biol"},{"key":"4513_CR52","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1007\/978-981-13-8023-5_64","volume":"1155","author":"S Li","year":"2019","unstructured":"Li S, Wang J, Wei BK, Dong G, Wang X (2019) Protective effect of taurine on paraquat-induced lung epithelial cell injury. Adv Exp Med Biol 1155:739\u2013746. https:\/\/doi.org\/10.1007\/978-981-13-8023-5_64","journal-title":"Adv Exp Med Biol"},{"key":"4513_CR53","doi-asserted-by":"crossref","unstructured":"Li Y, Li S, Xie X, Xiu H, Liu X, Shao J, Zhang X (2017) Neuroprotection by taurine on HBCD-induced apoptosis in PC12 cells. In: Taurine 10. Springer, Dordrecht, pp 95\u2013106","DOI":"10.1007\/978-94-024-1079-2_9"},{"issue":"12","key":"4513_CR54","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1089\/jmf.2014.3408","volume":"18","author":"CJ Lin","year":"2015","unstructured":"Lin CJ, Chiu CC, Chen YC, Chen ML, Hsu TC, Tzang BS (2015) Taurine attenuates hepatic inflammation in chronic alcohol-fed rats through inhibition of TLR4\/MyD88 signaling. J Medi Food 18(12):1291\u20131298. https:\/\/doi.org\/10.1089\/jmf.2014.3408","journal-title":"J Medi Food"},{"issue":"Pt 1","key":"4513_CR55","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/978-94-024-1079-2_10","volume":"975","author":"L Liu","year":"2017","unstructured":"Liu L, Guo L, Xie X et al (2017a) Taurine alleviate hexabromocyclododecane-induced cytotoxicity in PC12 cells via inhibiting oxidative stress. Adv Exp Med Biol 975(Pt 1):107\u2013117. https:\/\/doi.org\/10.1007\/978-94-024-1079-2_10","journal-title":"Adv Exp Med Biol"},{"issue":"5","key":"4513_CR56","doi-asserted-by":"publisher","first-page":"6512","DOI":"10.3892\/mmr.2017.7414","volume":"16","author":"Y Liu","year":"2017","unstructured":"Liu Y, Li F, Zhang L, Wu J, Wang Y, Yu H (2017b) Taurine alleviates lipopolysaccharide-induced liver injury by anti-inflammation and antioxidants in rats. Mol Med Rep 16(5):6512\u20136517. https:\/\/doi.org\/10.3892\/mmr.2017.7414","journal-title":"Mol Med Rep"},{"issue":"6","key":"4513_CR57","doi-asserted-by":"publisher","first-page":"584","DOI":"10.4062\/biomolther.2018.049","volume":"26","author":"J Lou","year":"2018","unstructured":"Lou J, Han D, Yu H, Yu G, Jin M, Kim SJ (2018) Cytoprotective effect of taurine against hydrogen peroxide-induced oxidative stress in UMR-106 cells through the Wnt\/beta-catenin signaling pathway. Biomol Ther (Seoul) 26(6):584\u2013590. https:\/\/doi.org\/10.4062\/biomolther.2018.049","journal-title":"Biomol Ther (Seoul)"},{"key":"4513_CR58","doi-asserted-by":"publisher","first-page":"104503","DOI":"10.1016\/j.cellimm.2022.104503","volume":"375","author":"Y Ma","year":"2022","unstructured":"Ma Y, Zhang Y, Li R et al (2022) Mechanism of taurine reducing inflammation and organ injury in sepsis mice. Cell Immunol 375:104503","journal-title":"Cell Immunol"},{"issue":"8","key":"4513_CR59","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1007\/s00018-018-3002-x","volume":"76","author":"S Magi","year":"2019","unstructured":"Magi S, Piccirillo S, Amoroso S (2019) The dual face of glutamate: from a neurotoxin to a potential survival factor-metabolic implications in health and disease. CMLS 76(8):1473\u20131488. https:\/\/doi.org\/10.1007\/s00018-018-3002-x","journal-title":"CMLS"},{"key":"4513_CR60","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.mrrev.2016.08.006","volume":"773","author":"T Mahaseth","year":"2017","unstructured":"Mahaseth T, Kuzminov A (2017) Potentiation of hydrogen peroxide toxicity: from catalase inhibition to stable DNA-iron complexes. Muta Res 773:274\u2013281. https:\/\/doi.org\/10.1016\/j.mrrev.2016.08.006","journal-title":"Muta Res"},{"issue":"3","key":"4513_CR61","doi-asserted-by":"publisher","first-page":"225","DOI":"10.34172\/PS.2020.17","volume":"26","author":"V Maleki","year":"2020","unstructured":"Maleki V, Mahdavi R, Hajizadeh-Sharafabad F, Alizadeh M (2020) A comprehensive insight into potential roles of taurine on metabolic variables in type 2 diabetes: a systematic review. Pharm Sci 26(3):225\u2013238","journal-title":"Pharm Sci"},{"issue":"2","key":"4513_CR62","doi-asserted-by":"publisher","first-page":"162","DOI":"10.3109\/01480545.2014.919585","volume":"38","author":"S Mehri","year":"2015","unstructured":"Mehri S, Meshki MA, Hosseinzadeh H (2015) Linalool as a neuroprotective agent against acrylamide-induced neurotoxicity in Wistar rats. Drug Chem Toxicol 38(2):162\u2013166. https:\/\/doi.org\/10.3109\/01480545.2014.919585","journal-title":"Drug Chem Toxicol"},{"issue":"1","key":"4513_CR63","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.cyto.2012.04.009","volume":"59","author":"J Miao","year":"2012","unstructured":"Miao J, Fa Y, Gu B, Zhu W, Zou S (2012) Taurine attenuates lipopolysaccharide-induced disfunction in mouse mammary epithelial cells. Cytokine 59(1):35\u201340. https:\/\/doi.org\/10.1016\/j.cyto.2012.04.009","journal-title":"Cytokine"},{"issue":"1","key":"4513_CR64","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.jhep.2005.01.033","volume":"43","author":"T Miyazaki","year":"2005","unstructured":"Miyazaki T, Karube M, Matsuzaki Y et al (2005) Taurine inhibits oxidative damage and prevents fibrosis in carbon tetrachloride-induced hepatic fibrosis. J Hepatol 43(1):117\u2013125","journal-title":"J Hepatol"},{"issue":"5","key":"4513_CR65","doi-asserted-by":"publisher","first-page":"4904","DOI":"10.1007\/s11356-017-0842-0","volume":"25","author":"L Mohammadzadeh","year":"2018","unstructured":"Mohammadzadeh L, Hosseinzadeh H, Abnous K, Razavi BM (2018) Neuroprotective potential of crocin against malathion-induced motor deficit and neurochemical alterations in rats. Environ Sci Pollut Res Int 25(5):4904\u20134914. https:\/\/doi.org\/10.1007\/s11356-017-0842-0","journal-title":"Environ Sci Pollut Res Int"},{"issue":"4","key":"4513_CR66","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1254\/jjp.32.583","volume":"32","author":"T Nakashima","year":"1982","unstructured":"Nakashima T, Taniko T, Kuriyama K (1982) Therapeutic effect of taurine administration on carbon tetrachloride-induced hepatic injury. Jpn J Pharmacol 32(4):583\u2013589. https:\/\/doi.org\/10.1254\/jjp.32.583","journal-title":"Jpn J Pharmacol"},{"key":"4513_CR67","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-024-04191-8","author":"K Naraki","year":"2024","unstructured":"Naraki K, Keshavarzi M, Razavi BM, Hosseinzadeh H (2024) The protective effects of taurine, a non-essential amino acid, against metals toxicities: a review article.\u00a0Biol Trace Elem Res 203:872\u2013890.\u00a0https:\/\/doi.org\/10.1007\/s12011-024-04191-8","journal-title":"Biol Trace Elem Res"},{"issue":"24","key":"4513_CR68","doi-asserted-by":"publisher","first-page":"2807","DOI":"10.1016\/s0024-3205(02)02135-5","volume":"71","author":"MB Newman","year":"2002","unstructured":"Newman MB, Arendash GW, Shytle RD, Bickford PC, Tighe T, Sanberg PR (2002) Nicotine\u2019s oxidative and antioxidant properties in CNS. Life Sci 71(24):2807\u20132820. https:\/\/doi.org\/10.1016\/s0024-3205(02)02135-5","journal-title":"Life Sci"},{"issue":"5","key":"4513_CR69","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1046\/j.1471-4159.2000.0742087.x","volume":"74","author":"MB O'Byrne","year":"2000","unstructured":"O\u2019Byrne MB, Tipton KF (2000) Taurine-induced attenuation of MPP+ neurotoxicity in vitro: a possible role for the GABA(A) subclass of GABA receptors. J Neurochem 74(5):2087\u20132093. https:\/\/doi.org\/10.1046\/j.1471-4159.2000.0742087.x","journal-title":"J Neurochem"},{"issue":"7","key":"4513_CR70","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1016\/j.fct.2009.04.018","volume":"47","author":"S Ozden","year":"2009","unstructured":"Ozden S, Catalgol B, Gezginci-Oktayoglu S, Arda-Pirincci P, Bolkent S, Alpertunga B (2009) Methiocarb-induced oxidative damage following subacute exposure and the protective effects of vitamin E and taurine in rats. Food Chem Toxicol: an International Journal Published for the British Industrial Biological Research Association 47(7):1676\u20131684. https:\/\/doi.org\/10.1016\/j.fct.2009.04.018","journal-title":"Food Chem Toxicol: an International Journal Published for the British Industrial Biological Research Association"},{"issue":"1","key":"4513_CR71","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1177\/0748233712446719","volume":"29","author":"S Ozden","year":"2013","unstructured":"Ozden S, Catalgol B, Gezginci-Oktayoglu S, Karatug A, Bolkent S, Alpertunga B (2013) Acute effects of methiocarb on oxidative damage and the protective effects of vitamin E and taurine in the liver and kidney of Wistar rats. Toxicol Ind Health 29(1):60\u201371","journal-title":"Toxicol Ind Health"},{"key":"4513_CR72","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1423-0127-17-S1-S18","volume":"17","author":"C Pan","year":"2010","unstructured":"Pan C, Gupta A, Prentice H, Wu J-Y (2010) Protection of taurine and granulocyte colony-stimulating factor against excitotoxicity induced by glutamate in primary cortical neurons. J Biomed Sci 17:1\u20136","journal-title":"J Biomed Sci"},{"key":"4513_CR73","doi-asserted-by":"crossref","unstructured":"Park SY, Ahn CB, Chang KJ, Kim SH, Lee W, Um JH et al (2017) Hepatoprotective effects of xylose-taurine reduced against hydrogen peroxide-induced oxidative stress in cultured hepatocytes. In: Taurine 10. Springer, Dordrecht, pp 621\u2013631","DOI":"10.1007\/978-94-024-1079-2_48"},{"issue":"2","key":"4513_CR74","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1093\/mutage\/16.2.91","volume":"16","author":"BJ Phillips","year":"2001","unstructured":"Phillips BJ, Jenkinson P (2001) Is ethanol genotoxic? A review of the published data. Mutagenesis 16(2):91\u2013101. https:\/\/doi.org\/10.1093\/mutage\/16.2.91","journal-title":"Mutagenesis"},{"issue":"1","key":"4513_CR75","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3164\/jcbn.10-120","volume":"49","author":"S Piao","year":"2011","unstructured":"Piao S, Cha YN, Kim C (2011) Taurine chloramine protects RAW 264.7 macrophages against hydrogen peroxide-induced apoptosis by increasing antioxidants. J Clinic Biochem Nutr 49(1):50\u20136. https:\/\/doi.org\/10.3164\/jcbn.10-120","journal-title":"J Clinic Biochem Nutr"},{"key":"4513_CR76","doi-asserted-by":"crossref","unstructured":"Pokhrel PK, Lau-Cam CA (2000) Protection by taurine and structurally related sulfur-containing compounds against erythrocyte membrane damage by hydrogen peroxide. In: Taurine 4: Taurine and Excitable Tissues. Springer, Boston, pp 411\u2013429","DOI":"10.1007\/0-306-46838-7_47"},{"key":"4513_CR77","doi-asserted-by":"crossref","unstructured":"Prentice H, Pan C, Gharibani PM, Ma Z, Price AL, Giraldo GS et al (2017) Analysis of neuroprotection by taurine and taurine combinations in primary neuronal cultures and in neuronal cell lines exposed to glutamate excitotoxicity and to hypoxia\/re-oxygenation. In: Taurine 10. Springer, Dordrecht, pp 207\u2013216","DOI":"10.1007\/978-94-024-1079-2_18"},{"issue":"6","key":"4513_CR78","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/S1566-2772(01)00019-6","volume":"1","author":"S Przedborski","year":"2001","unstructured":"Przedborski S, Vila M (2001) MPTP: a review of its mechanisms of neurotoxicity. Clinic Neurosci Res 1(6):407\u2013418","journal-title":"Clinic Neurosci Res"},{"issue":"1","key":"4513_CR79","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s00726-004-0066-8","volume":"27","author":"G Pushpakiran","year":"2004","unstructured":"Pushpakiran G, Mahalakshmi K, Anuradha CV (2004) Taurine restores ethanol-induced depletion of antioxidants and attenuates oxidative stress in rat tissues. Amino Acids 27(1):91\u201396. https:\/\/doi.org\/10.1007\/s00726-004-0066-8","journal-title":"Amino Acids"},{"issue":"4","key":"4513_CR80","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.1007\/s11356-017-0890-5","volume":"25","author":"MA Ramirez-Vargas","year":"2018","unstructured":"Ramirez-Vargas MA, Flores-Alfaro E, Uriostegui-Acosta M, Alvarez-Fitz P, Parra-Rojas I, Moreno-Godinez ME (2018) Effects of exposure to malathion on blood glucose concentration: a meta-analysis. Environ Sci Pollut Res Int 25(4):3233\u20133242. https:\/\/doi.org\/10.1007\/s11356-017-0890-5","journal-title":"Environ Sci Pollut Res Int"},{"key":"4513_CR81","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.fct.2012.10.007","volume":"51","author":"K Rashid","year":"2013","unstructured":"Rashid K, Das J, Sil PC (2013) Taurine ameliorate alloxan induced oxidative stress and intrinsic apoptotic pathway in the hepatic tissue of diabetic rats. Food Chem Toxicol: an International Journal Published for the British Industrial Biological Research Association 51:317\u2013329. https:\/\/doi.org\/10.1016\/j.fct.2012.10.007","journal-title":"Food Chem Toxicol: an International Journal Published for the British Industrial Biological Research Association"},{"issue":"1","key":"4513_CR82","doi-asserted-by":"publisher","first-page":"51","DOI":"10.22038\/ijbms.2019.37133.8845","volume":"23","author":"A Rezaee-Khorasany","year":"2020","unstructured":"Rezaee-Khorasany A, Razavi BM, Taghiabadi E, Tabatabaei Yazdi A, Hosseinzadeh H (2020) Effect of crocin, an active saffron constituent, on ethanol toxicity in the rat: histopathological and biochemical studies. Iran J Basic Med Sci 23(1):51\u201362. https:\/\/doi.org\/10.22038\/ijbms.2019.37133.8845","journal-title":"Iran J Basic Med Sci"},{"issue":"4","key":"4513_CR83","doi-asserted-by":"publisher","first-page":"428","DOI":"10.5935\/1518-0557.20200017","volume":"24","author":"F Rezaee-Tazangi","year":"2020","unstructured":"Rezaee-Tazangi F, Zeidooni L, Rafiee Z et al (2020) Taurine effects on bisphenol A-induced oxidative stress in the mouse testicular mitochondria and sperm motility. JBRA Assist Reprod 24(4):428\u2013435. https:\/\/doi.org\/10.5935\/1518-0557.20200017","journal-title":"JBRA Assist Reprod"},{"key":"4513_CR84","first-page":"2673","volume":"18","author":"H Ripps","year":"2012","unstructured":"Ripps H, Shen W (2012) Taurine: a \u201cvery essential\u201d amino acid. Mol vis 18:2673","journal-title":"Mol vis"},{"issue":"8","key":"4513_CR85","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.4314\/tjpr.v16i8.14","volume":"16","author":"AAS Saleh","year":"2017","unstructured":"Saleh AAS, Shahin MI, Kelada NA (2017) Hepatoprotective effect of taurine and coenzyme Q10 and their combination against acrylamide-induced oxidative stress in rats. Tropic J Pharm Res 16(8):1849\u20131855. https:\/\/doi.org\/10.4314\/tjpr.v16i8.14","journal-title":"Tropic J Pharm Res"},{"issue":"19","key":"4513_CR86","doi-asserted-by":"publisher","first-page":"4236","DOI":"10.3390\/nu15194236","volume":"15","author":"G Santulli","year":"2023","unstructured":"Santulli G, Kansakar U, Varzideh F, Mone P, Jankauskas SS, Lombardi A (2023) Functional role of taurine in aging and cardiovascular health: an updated overview. Nutrients 15(19):4236","journal-title":"Nutrients"},{"issue":"3","key":"4513_CR87","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.etap.2012.08.015","volume":"34","author":"RH Sayed","year":"2012","unstructured":"Sayed RH, Salem HA, El-Sayeh BM (2012) Potential protective effect of taurine against dibromoacetonitrile-induced neurotoxicity in rats. Environ Toxicol Pharmacol 34(3):849\u2013857. https:\/\/doi.org\/10.1016\/j.etap.2012.08.015","journal-title":"Environ Toxicol Pharmacol"},{"issue":"3","key":"4513_CR88","doi-asserted-by":"publisher","first-page":"225","DOI":"10.4062\/biomolther.2017.251","volume":"26","author":"S Schaffer","year":"2018","unstructured":"Schaffer S, Kim HW (2018) Effects and mechanisms of taurine as a therapeutic agent. Biomol Ther 26(3):225","journal-title":"Biomol Ther"},{"key":"4513_CR89","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1423-0127-17-S1-S2","volume":"17","author":"SW Schaffer","year":"2010","unstructured":"Schaffer SW, Jong C, R KC, J Azuma, (2010) Physiological roles of taurine in heart and muscle. J Biomed Sci 17:1\u20138","journal-title":"J Biomed Sci"},{"issue":"2","key":"4513_CR90","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/j.1472-8206.2005.00322.x","volume":"19","author":"G Sener","year":"2005","unstructured":"Sener G, Ozer Sehirli A, Ip\u00e7i Y et al (2005a) Taurine treatment protects against chronic nicotine-induced oxidative changes. Fund Clinic Pharmacol 19(2):155\u2013164. https:\/\/doi.org\/10.1111\/j.1472-8206.2005.00322.x","journal-title":"Fund Clinic Pharmacol"},{"issue":"1","key":"4513_CR91","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1159\/000083245","volume":"74","author":"G Sener","year":"2005","unstructured":"Sener G, Sehirli O, Ipci Y et al (2005b) Protective effects of taurine against nicotine-induced oxidative damage of rat urinary bladder and kidney. Pharmacol 74(1):37\u201344. https:\/\/doi.org\/10.1159\/000083245","journal-title":"Pharmacol"},{"key":"4513_CR92","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.fsi.2022.08.029","volume":"128","author":"Y Shi","year":"2022","unstructured":"Shi Y, Zhong L, Fan Y et al (2022) Taurine inhibits hydrogen peroxide-induced oxidative stress, inflammatory response and apoptosis in liver of Monopterus albus. Fish Shellfish Immunol 128:536\u2013546","journal-title":"Fish Shellfish Immunol"},{"key":"4513_CR93","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/BF03033565","volume":"11","author":"N Simola","year":"2007","unstructured":"Simola N, Morelli M, Carta AR (2007) The 6-hydroxydopamine model of Parkinson\u2019s disease. Neurotox Re 11:151\u2013167","journal-title":"Neurotox Re"},{"key":"4513_CR94","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2020.104351","volume":"77","author":"Q Song","year":"2021","unstructured":"Song Q, Guo J, Zhang Y, Chen W (2021) The beneficial effects of taurine in alleviating fatty liver disease. J Fun Food 77:104351","journal-title":"J Fun Food"},{"key":"4513_CR95","doi-asserted-by":"publisher","first-page":"205873841880532","DOI":"10.1177\/2058738418805322","volume":"32","author":"G Sun","year":"2018","unstructured":"Sun G, Qu S, Wang S, Shao Y, Sun J (2018a) Taurine attenuates acrylamide-induced axonal and myelinated damage through the Akt\/GSK3\u03b2-dependent pathway. Int J Immunopathol Pharmacol 32:2058738418805322. https:\/\/doi.org\/10.1177\/2058738418805322","journal-title":"Int J Immunopathol Pharmacol"},{"key":"4513_CR96","doi-asserted-by":"publisher","first-page":"960327118765335","DOI":"10.1177\/0960327118765335","volume":"1","author":"G Sun","year":"2018","unstructured":"Sun G, Wang X, Li T, Qu S, Sun J (2018b) Taurine attenuates acrylamide-induced apoptosis via a PI3K\/AKT-dependent manner. Human Exp Toxicol 1:960327118765335. https:\/\/doi.org\/10.1177\/0960327118765335","journal-title":"Human Exp Toxicol"},{"issue":"12","key":"4513_CR97","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.3390\/antiox10121876","volume":"10","author":"PF Surai","year":"2021","unstructured":"Surai PF, Earle-Payne K, Kidd MT (2021) Taurine as a natural antioxidant: from direct antioxidant effects to protective action in various toxicological models. Antioxidants 10(12):1876","journal-title":"Antioxidants"},{"issue":"2","key":"4513_CR98","first-page":"63","volume":"33","author":"M TIu","year":"1987","unstructured":"TIu M, Dokshina G (1987) Effect of taurine on the functional status of the insular apparatus and adrenal cortex of the rat with experimental diabetes. Probl Endokrinol 33(2):63\u201366","journal-title":"Probl Endokrinol"},{"issue":"36","key":"4513_CR99","doi-asserted-by":"publisher","first-page":"37242","DOI":"10.1007\/s11356-019-06615-8","volume":"26","author":"M Uzunhisarcikli","year":"2019","unstructured":"Uzunhisarcikli M, Aslanturk A (2019) Hepatoprotective effects of curcumin and taurine against bisphenol A-induced liver injury in rats. Environ Sci Pollut Res Int 26(36):37242\u201337253. https:\/\/doi.org\/10.1007\/s11356-019-06615-8","journal-title":"Environ Sci Pollut Res Int"},{"issue":"2","key":"4513_CR100","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.envres.2008.07.001","volume":"108","author":"SS Valenca","year":"2008","unstructured":"Valenca SS, Silva Bezerra F, Lopes AA et al (2008) Oxidative stress in mouse plasma and lungs induced by cigarette smoke and lipopolysaccharide. Environ Res 108(2):199\u2013204. https:\/\/doi.org\/10.1016\/j.envres.2008.07.001","journal-title":"Environ Res"},{"issue":"2","key":"4513_CR101","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1042\/bj1740621","volume":"174","author":"DA Vessey","year":"1978","unstructured":"Vessey DA (1978) The biochemical basis for the conjugation of bile acids with either glycine or taurine. Biochem J 174(2):621\u2013626","journal-title":"Biochem J"},{"issue":"1","key":"4513_CR102","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1076\/apab.109.1.90.4287","volume":"109","author":"BP Vohra","year":"2001","unstructured":"Vohra BP, Hui X (2001) Taurine protects against carbon tetrachloride toxicity in the cultured neurons and in vivo. Archi Physiol Biochem 109(1):90\u201394. https:\/\/doi.org\/10.1076\/apab.109.1.90.4287","journal-title":"Archi Physiol Biochem"},{"issue":"7\u20138","key":"4513_CR103","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1016\/j.neuint.2006.10.007","volume":"50","author":"HS Walton","year":"2007","unstructured":"Walton HS, Dodd PR (2007) Glutamate-glutamine cycling in Alzheimer\u2019s disease. Neurochem Int 50(7\u20138):1052\u20131066. https:\/\/doi.org\/10.1016\/j.neuint.2006.10.007","journal-title":"Neurochem Int"},{"issue":"1","key":"4513_CR104","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1536\/ihj.16-372","volume":"59","author":"J Wang","year":"2018","unstructured":"Wang J, Qi C, Liu L et al (2018) Taurine protects primary neonatal cardiomyocytes against apoptosis induced by hydrogen peroxide. Int Heart J 59(1):190\u2013196","journal-title":"Int Heart J"},{"issue":"4","key":"4513_CR105","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/0006-2952(93)90542-5","volume":"46","author":"CJ Waterfield","year":"1993","unstructured":"Waterfield CJ, Mesquita M, Parnham P, Timbrell JA (1993) Taurine protects against the cytotoxicity of hydrazine, 1, 4-naphthoquinone and carbon tetrachloride in isolated rat hepatocytes. Biochem Pharmacol 46(4):589\u2013595","journal-title":"Biochem Pharmacol"},{"issue":"2","key":"4513_CR106","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1080\/713611034","volume":"33","author":"LW Weber","year":"2003","unstructured":"Weber LW, Boll M, Stampfl A (2003) Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Critic Rev Toxicol 33(2):105\u2013136. https:\/\/doi.org\/10.1080\/713611034","journal-title":"Critic Rev Toxicol"},{"issue":"2","key":"4513_CR107","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.biochi.2008.09.006","volume":"91","author":"K Winiarska","year":"2009","unstructured":"Winiarska K, Szymanski K, Gorniak P, Dudziak M, Bryla J (2009) Hypoglycaemic, antioxidative and nephroprotective effects of taurine in alloxan diabetic rabbits. Biochimie 91(2):261\u2013270","journal-title":"Biochimie"},{"issue":"2","key":"4513_CR108","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1002\/(sici)1099-0461","volume":"13","author":"C Wu","year":"1999","unstructured":"Wu C, Kennedy DO, Yano Y, Otani S, Matsui-Yuasa I (1999) Thiols and polyamines in the cytoprotective effect of taurine on carbon tetrachloride-induced hepatotoxicity. J Biochem Mol Toxicol 13(2):71\u201376. https:\/\/doi.org\/10.1002\/(sici)1099-0461","journal-title":"J Biochem Mol Toxicol"},{"key":"4513_CR109","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s00726-018-2561-3","volume":"50","author":"G Wu","year":"2018","unstructured":"Wu G, Yang J, Lv H et al (2018) Taurine prevents ethanol-induced apoptosis mediated by mitochondrial or death receptor pathways in liver cells. Amino Acids 50:863\u2013875","journal-title":"Amino Acids"},{"issue":"5","key":"4513_CR110","doi-asserted-by":"publisher","first-page":"skab089","DOI":"10.1093\/jas\/skab089","volume":"99","author":"T Xing","year":"2021","unstructured":"Xing T, Chen X, Li J, Zhang L, Gao F (2021) Dietary taurine attenuates hydrogen peroxide-impaired growth performance and meat quality of broilers via modulating redox status and cell death signaling. J Anim Sci 99(5):skab089","journal-title":"J Anim Sci"},{"key":"4513_CR111","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1423-0127-17-S1-S6","volume":"17","author":"Y Yamori","year":"2010","unstructured":"Yamori Y, Taguchi T, Hamada A, Kunimasa K, Mori H, Mori M (2010) Taurine in health and diseases: consistent evidence from experimental and epidemiological studies. J Biomed Sci 17:1\u201314","journal-title":"J Biomed Sci"},{"issue":"2","key":"4513_CR112","doi-asserted-by":"publisher","first-page":"214","DOI":"10.31196\/huvfd.751318","volume":"9","author":"G Yar\u0131m","year":"2020","unstructured":"Yar\u0131m G, G\u00f6k\u00e7eo\u011flu A, Yar\u0131m M (2020) The effects of taurine on central nervous system. Harran \u00dcniversitesi Vet Fak Derg 9(2):214\u2013219","journal-title":"Harran \u00dcniversitesi Vet Fak Derg"},{"issue":"2","key":"4513_CR113","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.toxlet.2011.10.019","volume":"208","author":"T Zerin","year":"2012","unstructured":"Zerin T, Kim YS, Hong SY, Song HY (2012) Protective effect of methylprednisolone on paraquat-induced A549 cell cytotoxicity via induction of efflux transporter. P-Glycoprotein Expression Toxicol Lett 208(2):101\u2013107. https:\/\/doi.org\/10.1016\/j.toxlet.2011.10.019","journal-title":"P-Glycoprotein Expression Toxicol Lett"},{"issue":"1\u20132","key":"4513_CR114","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.tox.2007.06.091","volume":"239","author":"LP Zhang","year":"2007","unstructured":"Zhang LP, Wang QS, Guo X, Zhu YJ, Zhou GZ, Xie KQ (2007) Time-dependent changes of lipid peroxidation and antioxidative status in nerve tissues of hens treated with tri-ortho-cresyl phosphate (TOCP). Toxicol 239(1\u20132):45\u201352. https:\/\/doi.org\/10.1016\/j.tox.2007.06.091","journal-title":"Toxicol"},{"issue":"1","key":"4513_CR115","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s00726-009-0233-z","volume":"38","author":"F Zhang","year":"2010","unstructured":"Zhang F, Mao Y, Qiao H et al (2010) Protective effects of taurine against endotoxin-induced acute liver injury after hepatic ischemia reperfusion. Amino Acids 38(1):237\u2013245. https:\/\/doi.org\/10.1007\/s00726-009-0233-z","journal-title":"Amino Acids"},{"issue":"6","key":"4513_CR116","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.mib.2013.09.007","volume":"16","author":"G Zhang","year":"2013","unstructured":"Zhang G, Meredith TC, Kahne D (2013) On the essentiality of lipopolysaccharide to gram-negative bacteria. Curr Opin Microbiol 16(6):779\u2013785. https:\/\/doi.org\/10.1016\/j.mib.2013.09.007","journal-title":"Curr Opin Microbiol"},{"issue":"5","key":"4513_CR117","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1007\/s10495-017-1351-9","volume":"22","author":"Z Zhang","year":"2017","unstructured":"Zhang Z, Zhao L, Zhou Y et al (2017b) Taurine ameliorated homocysteine-induced H9C2 cardiomyocyte apoptosis by modulating endoplasmic reticulum stress. Apoptosis: Int J Program Cell Death 22(5):647\u2013661. https:\/\/doi.org\/10.1007\/s10495-017-1351-9","journal-title":"Apoptosis : Int J Program Cell Death"},{"key":"4513_CR118","doi-asserted-by":"crossref","unstructured":"Zhang X, Wang X, Zhang J, Pan X, Jiang J, Li Y (2017) Effects of taurine on alterations of neurobehavior and neurodevelopment key proteins expression in infant rats by exposure to hexabromocyclododecane. In: Taurine 10. Springer, Dordrecht, pp 119\u2013130","DOI":"10.1007\/978-94-024-1079-2_11"},{"key":"4513_CR119","doi-asserted-by":"publisher","unstructured":"Zhang Y, Guo H, Guo X, et al (2019) Involvement of Akt\/mTOR in the neurotoxicity of rotenone-induced Parkinson\u2019s disease models. Int J Environ Res Public Health 16(20). https:\/\/doi.org\/10.3390\/ijerph16203811","DOI":"10.3390\/ijerph16203811"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04513-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-025-04513-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04513-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T22:08:57Z","timestamp":1771538937000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-025-04513-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,12]]},"references-count":119,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["4513"],"URL":"https:\/\/doi.org\/10.1007\/s00210-025-04513-0","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,12]]},"assertion":[{"value":"18 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human ethics and consent to participate"}},{"value":"The authors declare no competing interests\u00a0article and also H.H. is the Editor of Naunyn-Schmiedebergs Arch Pharmacol and followed the submission guidelines of the journal (\n                      \n                      ).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}