{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:15:24Z","timestamp":1770884124301,"version":"3.50.1"},"reference-count":92,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s00210-025-04538-5","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T05:44:24Z","timestamp":1755755064000},"page":"2321-2335","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Succinic acid enhances sedative activity of diazepam through GABAergic receptor modulation: Evidence from behavioral approach and computational insights"],"prefix":"10.1007","volume":"399","author":[{"given":"Md. Sakib","family":"Al Hasan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasin","family":"Emon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Y.","family":"Alshahrani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imam Hossen","family":"Rakib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emon","family":"Mia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abida","family":"Sultana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akayed","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Torequl","family":"Islam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"4538_CR1","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.sleep.2021.03.028","volume":"82","author":"E Aernout","year":"2021","unstructured":"Aernout E, Benradia I, Hazo JB, Sy A, Askevis-Leherpeux F, Sebbane D, Roelandt JL (2021) International study of the prevalence and factors associated with insomnia in the general population. Sleep Med 82:186\u2013192. https:\/\/doi.org\/10.1016\/j.sleep.2021.03.028","journal-title":"Sleep Med"},{"issue":"12","key":"4538_CR2","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202400874","volume":"21","author":"A Aktar","year":"2024","unstructured":"Aktar A, Bhuia S, Chowdhury R, Ferdous J, Khatun M, Hasan SA, Mia E, Hasan R, Islam MT (2024) An insight of plant source, toxicological profile, and pharmacological activities of iridoid loganic acid: a comprehensivereview. Chem Biodivers 21(12):e202400874. https:\/\/doi.org\/10.1002\/cbdv.202400874","journal-title":"Chem Biodivers"},{"key":"4538_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.prenap.2024.100124","volume":"5","author":"MS Al Hasan","year":"2024","unstructured":"Al Hasan MS, Mia E, Yana NT, Rakib IH, Bhuia MS, Chowdhury R, Islam MT (2024) Allium cepa bioactive phytochemicals as potent ALK (anaplastic lymphoma kinase) inhibitors and therapeutic agents against non-small cell lung cancer (NSCLC): a computational study. Pharm Res Nat Prod 5:100124. https:\/\/doi.org\/10.1016\/j.prenap.2024.100124","journal-title":"Pharm Res Nat Prod"},{"key":"4538_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuroscience.2025.03.004","volume":"572","author":"MS Al Hasan","year":"2025","unstructured":"Al Hasan MS, Bhuia MS, Chowdhury R, Husain Z, Saifuzzaman M, Mia E, Akbor MS, Yana NT, Islam MA, Ansari SA, Ansari IA, Islam MT (2025) Tangeretin enhances sedative activity of diazepam in Swiss mice through GABAA receptor interaction: in vivo and in silico approaches. Neuroscience 572:1\u201310. https:\/\/doi.org\/10.1016\/j.neuroscience.2025.03.004","journal-title":"Neuroscience"},{"key":"4538_CR5","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.sleep.2024.12.007","volume":"126","author":"MS Al Hasan","year":"2025","unstructured":"Al Hasan MS, Bhuia MS, Sheikh S, Bithi SA, Saim MA, Kamli H, Ansari SA, Ahammed NT, Islam MT (2025) Assessment of sedative activity of Chrysin: behavioral approach with pharmacokinetics, toxicological profile and molecular docking. Sleep Med 126:88\u201396. https:\/\/doi.org\/10.1016\/j.sleep.2024.12.007","journal-title":"Sleep Med"},{"issue":"5","key":"4538_CR6","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1002\/med.20067","volume":"26","author":"H Alonso","year":"2006","unstructured":"Alonso H, Bliznyuk AA, Gready JE (2006) Combining docking and molecular dynamic simulations in drug design. Med Res Rev 26(5):531\u2013568. https:\/\/doi.org\/10.1002\/med.20067","journal-title":"Med Res Rev"},{"issue":"2","key":"4538_CR7","doi-asserted-by":"publisher","first-page":"98","DOI":"10.2174\/157489308784340694","volume":"3","author":"R Alves","year":"2008","unstructured":"Alves R, Vilaprinyo E, Sorribas A (2008) Integrating bioinformatics and computational biology: perspectives and possibilities for in silico network reconstruction in molecular systems biology. Curr Bioinform 3(2):98\u2013129","journal-title":"Curr Bioinform"},{"issue":"8","key":"4538_CR8","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1016\/j.biotechadv.2015.08.001","volume":"33","author":"AG Atanasov","year":"2015","unstructured":"Atanasov AG, Waltenberger B, Pferschy-Wenzig EM, Linder T, Wawrosch C, Uhrin P, Temml V, Wang L, Schwaiger S, Heiss EH, Rollinger JM, Schuster D, Breuss JM, Bochkov V, Mihovilovic MD, Kopp B, Bauer R, Dirsch VM, Stuppner H (2015) Discovery and resupply of pharmacologically active plant-derived natural products: a review. Biotechnol Adv 33(8):1582\u20131614. https:\/\/doi.org\/10.1016\/j.biotechadv.2015.08.001","journal-title":"Biotechnol Adv"},{"issue":"7","key":"4538_CR9","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/j.procbio.2010.03.035","volume":"45","author":"JJ Beauprez","year":"2010","unstructured":"Beauprez JJ, De Mey M, Soetaert WK (2010) Microbial succinic acid production: natural versus metabolic engineered producers. Process Biochem 45(7):1103\u20131114. https:\/\/doi.org\/10.1016\/j.procbio.2010.03.035","journal-title":"Process Biochem"},{"key":"4538_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2024.107403","volume":"106","author":"MS Bhuia","year":"2024","unstructured":"Bhuia MS, Al Hasan MS, Chowdhury R, Ansari SA, Ansari IA, Islam MT (2024) Trans-ferulic acid reduces the sedative activity of diazepam in thiopental sodium-induced sleeping mice: a potential GABAergic transmission. Neurotoxicol Teratol 106:107403. https:\/\/doi.org\/10.1016\/j.ntt.2024.107403","journal-title":"Neurotoxicol Teratol"},{"issue":"4","key":"4538_CR11","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s12032-025-02646-z","volume":"42","author":"SA Bithi","year":"2025","unstructured":"Bithi SA, Al Hasan MS, Bhuia MS, Mia E, Yana NT, Hasan AMW, Uddin MB, Sayeed MA, Emon Y, Hasan R, Chowdhury R, Islam MT (2025) Botanical sources, biopharmaceutical profile, anticancer effects with mechanistic insight, toxicological and clinical evidence of prunetin: a literature review. Med Oncol 42(4):87. https:\/\/doi.org\/10.1007\/s12032-025-02646-z","journal-title":"Med Oncol"},{"issue":"5","key":"4538_CR12","doi-asserted-by":"publisher","first-page":"152","DOI":"10.18773\/austprescr.2015.055","volume":"38","author":"J Brett","year":"2015","unstructured":"Brett J, Murnion B (2015) Management of benzodiazepine misuse and dependence. Aust Prescr 38(5):152\u2013155. https:\/\/doi.org\/10.18773\/austprescr.2015.055","journal-title":"Aust Prescr"},{"issue":"3","key":"4538_CR13","doi-asserted-by":"publisher","first-page":"255","DOI":"10.4103\/0253-7176.106022","volume":"34","author":"K Chandrasekhar","year":"2012","unstructured":"Chandrasekhar K, Kapoor J, Anishetty S (2012) A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med 34(3):255\u2013262. https:\/\/doi.org\/10.4103\/0253-7176.106022","journal-title":"Indian J Psychol Med"},{"issue":"4","key":"4538_CR14","first-page":"1029","volume":"3","author":"KK Chaudhary","year":"2016","unstructured":"Chaudhary KK, Mishra N (2016) A review on molecular docking: novel tool for drug discovery. Databases 3(4):1029","journal-title":"Databases"},{"issue":"25","key":"4538_CR15","doi-asserted-by":"publisher","first-page":"3257","DOI":"10.1016\/j.lfs.2003.06.017","volume":"73","author":"SW Chen","year":"2003","unstructured":"Chen SW, Xin Q, Kong WX, Min L, Li JF (2003) Anxiolytic-like effect of succinic acid in mice. Life Sci 73(25):3257\u20133264. https:\/\/doi.org\/10.1016\/j.lfs.2003.06.017","journal-title":"Life Sci"},{"issue":"1","key":"4538_CR16","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1158\/1078-0432.CCR-19-1871","volume":"27","author":"N Colclough","year":"2021","unstructured":"Colclough N, Chen K, Johnstr\u00f6m P, Strittmatter N, Yan Y, Wrigley GL, Schou M, Goodwin R, Varn\u00e4s K, Adua SJ, Zhao M, Nguyen DX, Maglennon G, Barton P, Atkinson J, Zhang L, Janefeldt A, Wilson J, Smith A, Takano A, Cross DAE (2021) Preclinical comparison of the blood-brain barrier permeability of osimertinib with other EGFR TKIs. Clin Cancer Res 27(1):189\u2013201. https:\/\/doi.org\/10.1158\/1078-0432.CCR-19-1871","journal-title":"Clin Cancer Res"},{"key":"4538_CR17","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1192\/bjp.133.3.239","volume":"133","author":"E Costa","year":"1978","unstructured":"Costa E, Guidotti A, Toffano G (1978) Molecular mechanisms mediating the action of diazepam on GABA receptors. Br J Psychiatry 133:239\u2013248. https:\/\/doi.org\/10.1192\/bjp.133.3.239","journal-title":"Br J Psychiatry"},{"issue":"4","key":"4538_CR18","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1007\/s11418-013-0754-3","volume":"67","author":"JB de la Pe\u00f1a","year":"2013","unstructured":"de la Pe\u00f1a JB, Lee HL, Yoon SY, Kim GH, Lee YS, Cheong JH (2013) The involvement of magnoflorine in the sedative and anxiolytic effects of Sinomeni Caulis et Rhizoma in mice. J Nat Med 67(4):814\u2013821. https:\/\/doi.org\/10.1007\/s11418-013-0754-3","journal-title":"J Nat Med"},{"key":"4538_CR19","doi-asserted-by":"crossref","unstructured":"de Souza Lopes C, Robaina JR, Rotenberg L (2012) Epidemiology of insomnia: prevalence and risk factors. In: Can\u2019t Sleep, pp 1\u201321","DOI":"10.5772\/32991"},{"issue":"24","key":"4538_CR20","doi-asserted-by":"publisher","first-page":"iii","DOI":"10.3310\/hta8240","volume":"8","author":"Y D\u00fcndar","year":"2004","unstructured":"D\u00fcndar Y, Boland A, Strobl J, Dodd S, Haycox A, Bagust A, Bogg J, Dickson R, Walley T (2004) Newer hypnotic drugs for the short-term management of insomnia: a systematic review and economic evaluation. Health Technol Assess 8(24):iii\u2013125. https:\/\/doi.org\/10.3310\/hta8240","journal-title":"Health Technol Assess"},{"issue":"3","key":"4538_CR21","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.pharmthera.2005.04.014","volume":"112","author":"B Ebert","year":"2006","unstructured":"Ebert B, Wafford KA, Deacon S (2006) Treating insomnia: current and investigational pharmacological approaches. Pharmacol Ther 112(3):612\u2013629. https:\/\/doi.org\/10.1016\/j.pharmthera.2005.04.014","journal-title":"Pharmacol Ther"},{"issue":"1","key":"4538_CR22","doi-asserted-by":"publisher","first-page":"122","DOI":"10.2174\/138945011793591626","volume":"12","author":"T Efferth","year":"2011","unstructured":"Efferth T, Koch E (2011) Complex interactions between phytochemicals. The multi-target therapeutic concept of phytotherapy. Curr Drug Targets 12(1):122\u2013132. https:\/\/doi.org\/10.2174\/138945011793591626","journal-title":"Curr Drug Targets"},{"key":"4538_CR23","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1007\/s002530051431","volume":"51","author":"JG Zeikus","year":"1999","unstructured":"Zeikus JG, Jain MK, Elankovan P (1999) Biotechnology of succinic acid production and markets for derived industrial products. Appl Microbiol Biotechnol 51:545\u2013552","journal-title":"Appl Microbiol Biotechnol"},{"issue":"1","key":"4538_CR24","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/sj.bjp.0707305","volume":"152","author":"S Ekins","year":"2007","unstructured":"Ekins S, Mestres J, Testa B (2007) In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling. Br J Pharmacol 152(1):9\u201320. https:\/\/doi.org\/10.1038\/sj.bjp.0707305","journal-title":"Br J Pharmacol"},{"key":"4538_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117592","volume":"253","author":"AA Elfiky","year":"2020","unstructured":"Elfiky AA (2020) Ribavirin, remdesivir, sofosbuvir, galidesivir, and tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): a molecular docking study. Life Sci 253:117592. https:\/\/doi.org\/10.1016\/j.lfs.2020.117592","journal-title":"Life Sci"},{"key":"4538_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.focha.2025.100998","volume":"7","author":"MA Eva","year":"2025","unstructured":"Eva MA, Mia E, Al Hasan MS, Chowdhury R, Yana NT, Rakib IH, Akter MS, Situ SG, Islam MT (2025) Fruit-derived bioactive compounds of Malus domestica as novel therapeutic inhibitors against Monkeypox and Marburg virus: a computational based drug discovery study. Food Chemistry Advances 7:100998. https:\/\/doi.org\/10.1016\/j.focha.2025.100998","journal-title":"Food Chemistry Advances"},{"issue":"37","key":"4538_CR27","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202403725","volume":"9","author":"J Ferdous","year":"2024","unstructured":"Ferdous J, Bhuia MS, Chowdhury R, Sheikh S, Ansari SA, Bappi MH, Islam MT (2024) Modulatory sedative activity of abrine on diazepam in thiopental sodium mediated sleeping mice: an in vivo approach with receptor binding affinity of GABAergic transmission. ChemistrySelect 9(37):e202403725. https:\/\/doi.org\/10.1002\/slct.202403725","journal-title":"ChemistrySelect"},{"issue":"1","key":"4538_CR28","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s43141-021-00224-0","volume":"19","author":"A Ghit","year":"2021","unstructured":"Ghit A, Assal D, Al-Shami AS, Hussein DEE (2021) GABAA receptors: structure, function, pharmacology, and related disorders. J Genet Eng Biotechnol 19(1):123. https:\/\/doi.org\/10.1186\/s43141-021-00224-0","journal-title":"J Genet Eng Biotechnol"},{"issue":"7","key":"4538_CR29","doi-asserted-by":"publisher","first-page":"9225","DOI":"10.1007\/s00210-025-03860-2","volume":"398","author":"PR Ghosh","year":"2025","unstructured":"Ghosh PR, Al Hasan MS, Rouf R, Chowdhury R, Yadav B, Mia E, Islam MT, Hasan MR, Ansari SA, Ansari IA, Bhuia MS, Islam MT (2025) Assessments of protodioscin\u2019s antinociceptive and antidiarrheal properties: in vivo and in silico investigations on macromolecule binding affinity and modulatory effects. Naunyn-Schmiedebergs Arch Pharmacol 398(7):9225. https:\/\/doi.org\/10.1007\/s00210-025-03860-2","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"4538_CR30","doi-asserted-by":"publisher","unstructured":"Gulias-Ca\u00f1izo R, Ru\u00edz-Leyja ED, S\u00e1nchez-Castillo H, Parod\u00ed J, Ochoa-de la Paz LD (2021) The role of GABA neurotransmitter in the human central nervous system, physiology, and pathophysiology. Rev Mex Neuroci 22(2):67\u201376. https:\/\/doi.org\/10.24875\/rmn.20000050","DOI":"10.24875\/rmn.20000050"},{"issue":"3","key":"4538_CR31","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1097\/01.aco.0000192811.56161.23","volume":"19","author":"S Hanada","year":"2006","unstructured":"Hanada S, Kawakami H, Goto T, Morita S (2006) Hypertension and anesthesia. Curr Opin Anaesthesiol 19(3):315\u2013319. https:\/\/doi.org\/10.1097\/01.aco.0000192811.56161.23","journal-title":"Curr Opin Anaesthesiol"},{"issue":"2","key":"4538_CR32","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1002\/bit.1098","volume":"74","author":"SH Hong","year":"2001","unstructured":"Hong SH, Lee SY (2001) Metabolic flux analysis for succinic acid production by recombinant Escherichia coli with amplified malic enzyme activity. Biotechnol Bioeng 74(2):89\u201395. https:\/\/doi.org\/10.1002\/bit.1098","journal-title":"Biotechnol Bioeng"},{"issue":"5","key":"4538_CR33","doi-asserted-by":"publisher","first-page":"5757","DOI":"10.1007\/s00210-024-03665-9","volume":"398","author":"MT Islam","year":"2025","unstructured":"Islam MT, Al Hasan MS, Chowdhury R, Mia E, Rakib IH, Yana NT, El-Nashar HAS, Ansari SA, Ansari IA, Islam MA, Almarhoon ZM, Setzer WN, Sharifi-Rad J (2025) Unveiling the anxiolytic and analgesic effects of citronellal in Swiss mice: in vivo and in silico insights into COX and GABAA receptor pathways. Naunyn-Schmiedebergs Arch Pharmacol 398(5):5757\u20135771. https:\/\/doi.org\/10.1007\/s00210-024-03665-9","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"4538_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2024.138060","volume":"845","author":"MT Islam","year":"2025","unstructured":"Islam MT, Al Hasan MS, Ferdous J, Mia E, Yana NT, Ansari IA, Ansari SA, Islam MA, Coutinho HDM (2025) Gabaaergic sedative prospection of sclareol-linalool co-treatment: an antagonistic intervention through in vivo and in silico studies. Neurosci Lett 845:138060. https:\/\/doi.org\/10.1016\/j.neulet.2024.138060","journal-title":"Neurosci Lett"},{"issue":"1","key":"4538_CR35","doi-asserted-by":"publisher","first-page":"13338","DOI":"10.1038\/s41598-023-40004-z","volume":"13","author":"T Kaden","year":"2023","unstructured":"Kaden T, Graf K, Rennert K, Li R, Mosig AS, Raasch M (2023) Evaluation of drug-induced liver toxicity of trovafloxacin and levofloxacin in a human microphysiological liver model. Sci Rep 13(1):13338. https:\/\/doi.org\/10.1038\/s41598-023-40004-z","journal-title":"Sci Rep"},{"issue":"6","key":"4538_CR36","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1017\/S1461145714000017","volume":"17","author":"S Kasper","year":"2014","unstructured":"Kasper S, Gastpar M, M\u00fcller WE, Volz HP, M\u00f6ller HJ, Schl\u00e4fke S, Dienel A (2014) Lavender oil preparation Silexan is effective in generalized anxiety disorder\u2014a randomized, double-blind comparison to placebo and paroxetine. Int J Neuropsychopharmacol 17(6):859\u2013869. https:\/\/doi.org\/10.1017\/S1461145714000017","journal-title":"Int J Neuropsychopharmacol"},{"issue":"1","key":"4538_CR37","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/nrd1609","volume":"4","author":"CT Keith","year":"2005","unstructured":"Keith CT, Borisy AA, Stockwell BR (2005) Multicomponent therapeutics for networked systems. Nat Rev Drug Discov 4(1):71\u201378. https:\/\/doi.org\/10.1038\/nrd1609","journal-title":"Nat Rev Drug Discov"},{"issue":"7","key":"4538_CR38","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/s1359-6446(03)02649-7","volume":"8","author":"EH Kerns","year":"2003","unstructured":"Kerns EH, Di L (2003) Pharmaceutical profiling in drug discovery. Drug Discov Today 8(7):316\u2013323. https:\/\/doi.org\/10.1016\/s1359-6446(03)02649-7","journal-title":"Drug Discov Today"},{"issue":"2","key":"4538_CR39","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.plasmid.2003.11.003","volume":"51","author":"P Kim","year":"2004","unstructured":"Kim P, Laivenieks M, McKinlay J, Vieille C, Gregory Zeikus J (2004) Construction of a shuttle vector for the overexpression of recombinant proteins in Actinobacillus succinogenes. Plasmid 51(2):108\u2013115. https:\/\/doi.org\/10.1016\/j.plasmid.2003.11.003","journal-title":"Plasmid"},{"key":"4538_CR40","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/978-1-4939-7201-2_18","volume":"1647","author":"M Kontoyianni","year":"2017","unstructured":"Kontoyianni M (2017) Docking and virtual screening in drug discovery. Methods Mol Biol 1647:255\u2013266. https:\/\/doi.org\/10.1007\/978-1-4939-7201-2_18","journal-title":"Methods Mol Biol"},{"issue":"9","key":"4538_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10092159","volume":"10","author":"K Kuna","year":"2022","unstructured":"Kuna K, Szewczyk K, Gabryelska A, Bia\u0142asiewicz P, Ditmer M, Strzelecki D, Sochal M (2022) Potential role of sleep deficiency in inducing immune dysfunction. Biomedicines 10(9):2159. https:\/\/doi.org\/10.3390\/biomedicines10092159","journal-title":"Biomedicines"},{"issue":"5","key":"4538_CR42","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s00253-002-0935-6","volume":"58","author":"PC Lee","year":"2002","unstructured":"Lee PC, Lee SY, Hong SH, Chang HN (2002) Isolation and characterization of a new succinic acid-producing bacterium, Mannheimia succiniciproducens MBEL55E, from bovine rumen. Appl Microbiol Biotechnol 58(5):663\u2013668. https:\/\/doi.org\/10.1007\/s00253-002-0935-6","journal-title":"Appl Microbiol Biotechnol"},{"issue":"2","key":"4538_CR43","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1023\/a:1021907116361","volume":"25","author":"PC Lee","year":"2003","unstructured":"Lee PC, Lee SY, Hong SH, Chang HN, Park SC (2003) Biological conversion of wood hydrolysate to succinic acid by Anaerobiospirillum succiniciproducens. Biotechnol Lett 25(2):111\u2013114. https:\/\/doi.org\/10.1023\/a:1021907116361","journal-title":"Biotechnol Lett"},{"issue":"4","key":"4538_CR44","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.ddtec.2004.11.007","volume":"1","author":"CA Lipinski","year":"2004","unstructured":"Lipinski CA (2004) Lead- and drug-like compounds: the rule-of-five revolution. Drug Discov Today Technol 1(4):337\u2013341. https:\/\/doi.org\/10.1016\/j.ddtec.2004.11.007","journal-title":"Drug Discov Today Technol"},{"key":"4538_CR45","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.lfs.2019.01.006","volume":"219","author":"H Liu","year":"2019","unstructured":"Liu H, Chen A (2019) Roles of sleep deprivation in cardiovascular dysfunctions. Life Sci 219:231\u2013237. https:\/\/doi.org\/10.1016\/j.lfs.2019.01.006","journal-title":"Life Sci"},{"key":"4538_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109065","volume":"110","author":"H Liu","year":"2022","unstructured":"Liu H, Zhang H, Zhang X, Chen Q, Xia L (2022) Role of succinic acid in the regulation of sepsis. Int Immunopharmacol 110:109065. https:\/\/doi.org\/10.1016\/j.intimp.2022.109065","journal-title":"Int Immunopharmacol"},{"key":"4538_CR47","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00163","volume":"13","author":"JM Lorenz-Guertin","year":"2019","unstructured":"Lorenz-Guertin JM, Bambino MJ, Das S, Weintraub ST, Jacob TC (2019) Diazepam accelerates GABAAR synaptic exchange and alters intracellular trafficking. Front Cell Neurosci 13:163. https:\/\/doi.org\/10.3389\/fncel.2019.00163","journal-title":"Front Cell Neurosci"},{"key":"4538_CR48","doi-asserted-by":"crossref","unstructured":"Mahajan B, Gawarkar-Patil P, Adnaik P, Bagade N, Gondhale-Karpe P, Manwatkar S, Patil S (2024) Applications of computational tools in the prediction of toxicity. In: Biosystems, Biomedical & Drug Delivery Systems: Characterization, Restoration and Optimization. Singapore: Springer Nature Singapore, , pp 311\u2013326","DOI":"10.1007\/978-981-97-2596-0_14"},{"issue":"2","key":"4538_CR49","doi-asserted-by":"publisher","first-page":"146","DOI":"10.2174\/157340911795677602","volume":"7","author":"XY Meng","year":"2011","unstructured":"Meng XY, Zhang HX, Mezei M, Cui M (2011) Molecular docking: a powerful approach for structure-based drug discovery. Curr Comput Aided Drug Des 7(2):146\u2013157. https:\/\/doi.org\/10.2174\/157340911795677602","journal-title":"Curr Comput Aided Drug Des"},{"key":"4538_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2023.103044","volume":"55","author":"MN Mia","year":"2023","unstructured":"Mia MN, Smrity SZ, Bappi MH, Kamli H, Islam T, Prottay AAS, Islam MT (2023) Anxiolytic-like effect of succinic acid: a possible GABAergic intervention. Food Biosci 55:103044. https:\/\/doi.org\/10.1016\/j.fbio.2023.103044","journal-title":"Food Biosci"},{"key":"4538_CR51","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/873954","volume":"2015","author":"M Moniruzzaman","year":"2015","unstructured":"Moniruzzaman M, Atikur Rahman M, Ferdous A (2015) Evaluation of sedative and hypnotic activity of ethanolic extract of Scoparia dulcis Linn. Evid Based Complement Alternat Med 2015:873954. https:\/\/doi.org\/10.1155\/2015\/873954","journal-title":"Evid Based Complement Alternat Med"},{"issue":"1","key":"4538_CR52","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s42826-022-00128-1","volume":"38","author":"P Mukherjee","year":"2022","unstructured":"Mukherjee P, Roy S, Ghosh D, Nandi SK (2022) Role of animal models in biomedical research: a review. Lab Anim Res 38(1):18. https:\/\/doi.org\/10.1186\/s42826-022-00128-1","journal-title":"Lab Anim Res"},{"issue":"6","key":"4538_CR53","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.22250","volume":"85","author":"SA Mukty","year":"2024","unstructured":"Mukty SA, Hasan R, Bhuia MS, Saha AK, Rahman US, Khatun MM, Bithi SA, Ansari SA, Ansari IA, Islam MT (2024) Assessment of sedative activity of fraxin: in vivo approach along with receptor binding affinity and molecular interaction with GABAergic system. Drug Dev Res 85(6):e22250. https:\/\/doi.org\/10.1002\/ddr.22250","journal-title":"Drug Dev Res"},{"key":"4538_CR54","doi-asserted-by":"publisher","unstructured":"Ni J, Yang Y, Wang Q, Bergholz JS, Jiang T, Roberts TM, Zhao JJ (2021) Targeting EGFR in glioblastoma with a novel brain-penetrant small molecule EGFR-TKI. bioRxiv 2021\u201301. https:\/\/doi.org\/10.1101\/2021.01.09.426030","DOI":"10.1101\/2021.01.09.426030"},{"issue":"2","key":"4538_CR55","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.smrv.2008.01.001","volume":"12","author":"MM Ohayon","year":"2008","unstructured":"Ohayon MM (2008) From wakefulness to excessive sleepiness: what we know and still need to know. Sleep Med Rev 12(2):129\u2013141. https:\/\/doi.org\/10.1016\/j.smrv.2008.01.001","journal-title":"Sleep Med Rev"},{"issue":"Pt A","key":"4538_CR56","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.neuropharm.2018.01.036","volume":"136","author":"RW Olsen","year":"2018","unstructured":"Olsen RW (2018) GABAA receptor: positive and negative allosteric modulators. Neuropharmacology 136(Pt A):10\u201322. https:\/\/doi.org\/10.1016\/j.neuropharm.2018.01.036","journal-title":"Neuropharmacology"},{"issue":"7","key":"4538_CR57","doi-asserted-by":"publisher","first-page":"522","DOI":"10.4236\/jbbs.2013.37055","volume":"3","author":"S Ouakki","year":"2013","unstructured":"Ouakki S, El Mrabet FZ, Lagbouri I, El Hessni A, Mesfioui A, P\u00e9vet P, Ouichou A (2013) Melatonin and diazepam affect anxiety-like and depression-like behavior in Wistar rats: Possible interaction with central GABA neurotransmission. J Behav Brain Sci 3(7):522\u2013533","journal-title":"J Behav Brain Sci"},{"issue":"10","key":"4538_CR58","doi-asserted-by":"publisher","first-page":"927","DOI":"10.2146\/ajhp060640","volume":"65","author":"S Passarella","year":"2008","unstructured":"Passarella S, Duong MT (2008) Diagnosis and treatment of insomnia. Am J Health Syst Pharm 65(10):927\u2013934. https:\/\/doi.org\/10.2146\/ajhp060640","journal-title":"Am J Health-Syst Pharm"},{"issue":"1","key":"4538_CR59","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s40360-018-0282-6","volume":"20","author":"L Pu","year":"2019","unstructured":"Pu L, Naderi M, Liu T, Wu HC, Mukhopadhyay S, Brylinski M (2019) Etoxpred: a machine learning-based approach to estimate the toxicity of drug candidates. BMC Pharmacol Toxicol 20(1):2. https:\/\/doi.org\/10.1186\/s40360-018-0282-6","journal-title":"BMC Pharmacol Toxicol"},{"issue":"1","key":"4538_CR60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1071\/HR21005","volume":"33","author":"ID Rae","year":"2022","unstructured":"Rae ID (2022) Responses by Australian pharmacologists to respiratory depression caused by opiates and barbiturates. Hist Rec Aust Sci 33(1):1\u201311","journal-title":"Hist Rec Aust Sci"},{"issue":"2","key":"4538_CR61","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1002\/wcms.1240","volume":"6","author":"AB Raies","year":"2016","unstructured":"Raies AB, Bajic VB (2016) In silico toxicology: computational methods for the prediction of chemical toxicity. WIREs Comput Mol Sci 6(2):147\u2013172. https:\/\/doi.org\/10.1002\/wcms.1240","journal-title":"WIREs Comput Mol Sci"},{"key":"4538_CR62","doi-asserted-by":"publisher","unstructured":"Rakib IH, Khan MS, Ayub A, Al Hasan MS, Alfaifi M, Bhuia MS, Mia E, Yana NT, Shipon MNH, Torequl Islam M (2025) Salvianolic acid A enhances sedative effect of diazepam through the GABAergic pathway: In vivo, molecular docking, and pharmacokinetics approaches. Neurotoxicol Teratol 107517.  https:\/\/doi.org\/10.1016\/j.ntt.2025.107517. Advance online publication","DOI":"10.1016\/j.ntt.2025.107517"},{"key":"4538_CR63","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.sleep.2015.02.535","volume":"18","author":"VR Rangaraj","year":"2016","unstructured":"Rangaraj VR, Knutson KL (2016) Association between sleep deficiency and cardiometabolic disease: implications for health disparities. Sleep Med 18:19\u201335. https:\/\/doi.org\/10.1016\/j.sleep.2015.02.535","journal-title":"Sleep Med"},{"issue":"6","key":"4538_CR64","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e16754","volume":"9","author":"ASMA Reza","year":"2023","unstructured":"Reza ASMA, Sakib MA, Nasrin MS, Khan J, Khan MF, Hossen MA, Ali MH, Haque MA (2023) Lasia spinosa (L.) Thw. attenuates chemically induced behavioral disorders in experimental and computational models. Heliyon 9(6):e16754. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e16754","journal-title":"Heliyon"},{"issue":"5 Suppl","key":"4538_CR65","doi-asserted-by":"publisher","first-page":"S7","DOI":"10.5664\/jcsm.26929","volume":"3","author":"T Roth","year":"2007","unstructured":"Roth T (2007) Insomnia: definition, prevalence, etiology, and consequences. J Clin Sleep Med 3(5 Suppl):S7\u2013S10","journal-title":"J Clin Sleep Med"},{"issue":"9","key":"4538_CR66","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/nrd3502","volume":"10","author":"U Rudolph","year":"2011","unstructured":"Rudolph U, Knoflach F (2011) Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes. Nat Rev Drug Discov 10(9):685\u2013697. https:\/\/doi.org\/10.1038\/nrd3502","journal-title":"Nat Rev Drug Discov"},{"key":"4538_CR67","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2024.107561","volume":"130","author":"MA Saim","year":"2024","unstructured":"Saim MA, Bhuia MS, Eity TA, Chowdhury R, Ahammed NT, Ansari SA, Hossain KN, Luna AA, Munshi MH, Islam MT (2024) Assessment of antiemetic activity of dihydrocoumarin: in vivo and in silico approaches on receptor binding affinity and modulatory effects. J Pharmacol Toxicol Methods 130:107561. https:\/\/doi.org\/10.1016\/j.vascn.2024.107561","journal-title":"J Pharmacol Toxicol Methods"},{"key":"4538_CR68","doi-asserted-by":"publisher","DOI":"10.7573\/dic.212257","volume":"2013","author":"TL Schwartz","year":"2013","unstructured":"Schwartz TL, Goradia V (2013) Managing insomnia: an overview of insomnia and pharmacologic treatment strategies in use and on the horizon. Drugs Context 2013:212257. https:\/\/doi.org\/10.7573\/dic.212257","journal-title":"Drugs Context"},{"key":"4538_CR69","doi-asserted-by":"publisher","DOI":"10.1016\/j.focha.2025.100930","volume":"6","author":"KK Sharma","year":"2025","unstructured":"Sharma KK, Al Hasan MS, Rouf R, Emon Y, Mia E, Hossan R, Islam MT (2025) Assessment of antiemetic and modulatory activity of dihydrocoumarin on copper sulfate induced emetic chicks: an in vivo investigation. Food Chem Adv 6:100930. https:\/\/doi.org\/10.1016\/j.focha.2025.100930","journal-title":"Food Chem Adv"},{"issue":"3","key":"4538_CR70","doi-asserted-by":"publisher","first-page":"289","DOI":"10.2174\/1570159X11666131227001243","volume":"12","author":"Y Shi","year":"2014","unstructured":"Shi Y, Dong JW, Zhao JH, Tang LN, Zhang JJ (2014) Herbal insomnia medications that target GABAergic systems: a review of the psychopharmacological evidence. Curr Neuropharmacol 12(3):289\u2013302. https:\/\/doi.org\/10.2174\/1570159X11666131227001243","journal-title":"Curr Neuropharmacol"},{"issue":"3","key":"4538_CR71","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/s41593-022-01013-9","volume":"25","author":"Y Shi","year":"2022","unstructured":"Shi Y, Cui M, Ochs K, Brendel ML, Str\u00fcbing FL, Briel N, Eckenweber F, Zou C, Banati RB, Liu GJ, Middleton RJ, Rupprecht R, Rudolph U, Zeilhofer HU, Rammes G, Herms J, Dorostkar MM (2022) Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO). Nat Neurosci 25(3):317\u2013329. https:\/\/doi.org\/10.1038\/s41593-022-01013-9","journal-title":"Nat Neurosci"},{"issue":"3","key":"4538_CR72","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.mcna.2010.02.005","volume":"94","author":"AT Siebern","year":"2010","unstructured":"Siebern AT, Manber R (2010) Insomnia and its effective non-pharmacologic treatment. Med Clin North Am 94(3):581\u2013591. https:\/\/doi.org\/10.1016\/j.mcna.2010.02.005","journal-title":"Med Clin North Am"},{"issue":"2","key":"4538_CR73","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1111\/j.1476-5381.2011.01779.x","volume":"166","author":"W Sieghart","year":"2012","unstructured":"Sieghart W, Ramerstorfer J, Sarto-Jackson I, Varagic Z, Ernst M (2012) A novel GABA(A) receptor pharmacology: drugs interacting with the \u03b1(+) \u03b2(\u2212) interface. Br J Pharmacol 166(2):476\u2013485. https:\/\/doi.org\/10.1111\/j.1476-5381.2011.01779.x","journal-title":"Br J Pharmacol"},{"issue":"48","key":"4538_CR74","doi-asserted-by":"publisher","first-page":"40224","DOI":"10.1074\/jbc.R112.386664","volume":"287","author":"E Sigel","year":"2012","unstructured":"Sigel E, Steinmann ME (2012) Structure, function, and modulation of GABA(A) receptors. J Biol Chem 287(48):40224\u201340231. https:\/\/doi.org\/10.1074\/jbc.R112.386664","journal-title":"J Biol Chem"},{"issue":"1\u20132","key":"4538_CR75","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.tox.2006.04.032","volume":"224","author":"B Simon-Hettich","year":"2006","unstructured":"Simon-Hettich B, Rothfuss A, Steger-Hartmann T (2006) Use of computer-assisted prediction of toxic effects of chemical substances. Toxicology 224(1\u20132):156\u2013162","journal-title":"Toxicology"},{"issue":"2","key":"4538_CR76","doi-asserted-by":"publisher","first-page":"165","DOI":"10.2174\/138920006775541552","volume":"7","author":"SS Singh","year":"2006","unstructured":"Singh SS (2006) Preclinical pharmacokinetics: an approach towards safer and efficacious drugs. Curr Drug Metab 7(2):165\u2013182. https:\/\/doi.org\/10.2174\/138920006775541552","journal-title":"Curr Drug Metab"},{"issue":"1","key":"4538_CR77","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1124\/pr.112.007336","volume":"66","author":"G Sliwoski","year":"2013","unstructured":"Sliwoski G, Kothiwale S, Meiler J, Lowe EW Jr (2013) Computational methods in drug discovery. Pharmacol Rev 66(1):334\u2013395. https:\/\/doi.org\/10.1124\/pr.112.007336","journal-title":"Pharmacol Rev"},{"key":"4538_CR78","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.ejmech.2019.03.043","volume":"171","author":"VR Solomon","year":"2019","unstructured":"Solomon VR, Tallapragada VJ, Chebib M, Johnston GAR, Hanrahan JR (2019) GABA allosteric modulators: an overview of recent developments in non-benzodiazepine modulators. Eur J Med Chem 171:434\u2013461. https:\/\/doi.org\/10.1016\/j.ejmech.2019.03.043","journal-title":"Eur J Med Chem"},{"key":"4538_CR79","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/bs.pmch.2021.01.004","volume":"60","author":"F Stanzione","year":"2021","unstructured":"Stanzione F, Giangreco I, Cole JC (2021) Use of molecular docking computational tools in drug discovery. Prog Med Chem 60:273\u2013343. https:\/\/doi.org\/10.1016\/bs.pmch.2021.01.004","journal-title":"Prog Med Chem"},{"key":"4538_CR80","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1590\/S0102-695X2008000400004","volume":"18","author":"N Subhan","year":"2008","unstructured":"Subhan N, Alam MA, Ahmed F, Shahid IJ, Nahar L, Sarker SD (2008) Bioactivity of Excoecaria agallocha. Rev Bras Farmacogn 18:521\u2013526","journal-title":"Rev Bras Farmacogn"},{"issue":"4","key":"4538_CR81","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.tins.2011.01.004","volume":"34","author":"KR Tan","year":"2011","unstructured":"Tan KR, Rudolph U, L\u00fcscher C (2011) Hooked on benzodiazepines: GABAA receptor subtypes and addiction. Trends Neurosci 34(4):188\u2013197. https:\/\/doi.org\/10.1016\/j.tins.2011.01.004","journal-title":"Trends Neurosci"},{"issue":"1","key":"4538_CR82","doi-asserted-by":"publisher","first-page":"10","DOI":"10.16966\/2575-0305.106","volume":"2","author":"A Tripathi","year":"2017","unstructured":"Tripathi A, Bankaitis VA (2017) Molecular docking: from lock and key to combination lock. J Mol Med Clin Appl 2(1):10\u201316966. https:\/\/doi.org\/10.16966\/2575-0305.106","journal-title":"J Mol Med Clin Appl"},{"key":"4538_CR83","unstructured":"Turner R (2013) Screening methods in pharmacology. Elsevier"},{"issue":"5","key":"4538_CR84","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1021\/acsbiomedchemau.4c00040","volume":"4","author":"MA Ur Rehman","year":"2024","unstructured":"Ur Rehman MA, Chuntakaruk H, Amphan S, Suroengrit A, Hengphasatporn K, Shigeta Y, Rungrotmongkol T, Krusong K, Boonyasuppayakorn S, Aonbangkhen C, Khotavivattana T (2024) Design, synthesis, and biological evaluation of darunavir analogs as HIV-1 protease inhibitors. ACS Bio Med Chem Au 4(5):242\u2013256. https:\/\/doi.org\/10.1021\/acsbiomedchemau.4c00040","journal-title":"ACS Bio Med Chem Au"},{"issue":"5","key":"4538_CR85","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1002\/wcms.52","volume":"1","author":"O Ursu","year":"2011","unstructured":"Ursu O, Rayan A, Goldblum A, Oprea TI (2011) Understanding drug-likeness. Wiley Interdiscip Rev Comput Mol Sci 1(5):760\u2013781. https:\/\/doi.org\/10.1002\/wcms.52","journal-title":"Wiley Interdiscip Rev Comput Mol Sci"},{"key":"4538_CR86","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/416864","volume":"2012","author":"CH Vinkers","year":"2012","unstructured":"Vinkers CH, Olivier B (2012) Mechanisms underlying tolerance after long-term benzodiazepine use: a future for subtype-selective GABA(A) receptor modulators? Adv Pharmacol Sci 2012:416864. https:\/\/doi.org\/10.1155\/2012\/416864","journal-title":"Adv Pharmacol Sci"},{"key":"4538_CR87","unstructured":"Walker M (2017) Why we sleep: unlocking the power of sleep and dreams. Simon and Schuster"},{"issue":"2","key":"4538_CR88","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s43440-024-00689-z","volume":"77","author":"A Wis\u0142owska-Stanek","year":"2025","unstructured":"Wis\u0142owska-Stanek A, Jarkiewicz M, Mirowska-Guzel D (2025) Rebound effect, discontinuation, and withdrawal syndromes associated with drugs used in psychiatric and neurological disorders. Pharmacol Rep 77(2):303\u2013314. https:\/\/doi.org\/10.1007\/s43440-024-00689-z","journal-title":"Pharmacol Rep"},{"key":"4538_CR89","unstructured":"Xu Z (2005) Topology characterization of a benzodiazepine-binding domain of GABA (A) receptor and anxiolytic-like effect of baicalin acting through the benzodiazepine-binding site. Hong Kong University of Science and Technology (Hong Kong)"},{"issue":"3","key":"4538_CR90","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1007\/s10517-012-1709-5","volume":"153","author":"IV Zarubina","year":"2012","unstructured":"Zarubina IV, Lukk MV, Shabanov PD (2012) Antihypoxic and antioxidant effects of exogenous succinic acid and aminothiol succinate-containing antihypoxants. Bull Exp Biol Med 153(3):336\u2013339. https:\/\/doi.org\/10.1007\/s10517-012-1709-5","journal-title":"Bull Exp Biol Med"},{"issue":"5","key":"4538_CR91","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1002\/ptr.5052","volume":"28","author":"QC Zhang","year":"2014","unstructured":"Zhang QC, Zhao Y, Bian HM (2014) Anti-thrombotic effect of a novel formula from Corni fructus with malic acid, succinic acid and citric acid. Phytother Res 28(5):722\u2013727. https:\/\/doi.org\/10.1002\/ptr.5052","journal-title":"Phytother Res"},{"issue":"1\u20132","key":"4538_CR92","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.drudis.2006.11.008","volume":"12","author":"GR Zimmermann","year":"2007","unstructured":"Zimmermann GR, Leh\u00e1r J, Keith CT (2007) Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov Today 12(1\u20132):34\u201342. https:\/\/doi.org\/10.1016\/j.drudis.2006.11.008","journal-title":"Drug Discov Today"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04538-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-025-04538-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-025-04538-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:47:26Z","timestamp":1770882446000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-025-04538-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,21]]},"references-count":92,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["4538"],"URL":"https:\/\/doi.org\/10.1007\/s00210-025-04538-5","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,21]]},"assertion":[{"value":"5 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}